Rosinsulin P, S, M

Hypoglycemic wakili, insulin-gajeren aiki. Yin hulɗa tare da takamaiman mai karɓa akan membrane na sel, yana samar da hadaddun mai karɓar insulin. Ta hanyar haɓaka kwayar CAMP (a cikin ƙwayoyin mai da ƙwayoyin hanta) ko kai tsaye shiga cikin tantanin halitta (tsokoki), ƙwaƙwalwar mai ɗaukar insulin ɗin tana ta motsa hanyoyin cikin ciki, gami da kira na enzymes masu yawa (ciki har da hexokinase, pyruvate kinase, glycogen synthetase).

Rage yawan haɗuwa da glucose a cikin jini shine lalacewa ta hanyar karuwa a cikin jijiyarsa, haɓaka sha da kwarjini da kyallen takarda, haɓakar lipogenesis, glycogenogenesis, ƙwayar sunadarai, da raguwa a cikin yawan samar da glucose ta hanta (rage raguwar glycogen).

Farawar aiki shine bayan minti 30, matsakaicin sakamako shine bayan sa'o'i 1-3, tsawon lokacin aikin shine awoyi 8.

Sakawa lokacin

Matsayi da hanyar gudanar da maganin an ƙayyade su daban-daban a kowane yanayi dangane da abubuwan da ke cikin glucose a cikin jini kafin cin abinci da sa'o'i 1-2 bayan cin abinci, sannan kuma ya danganta da matsayin glucosuria da halayen hanyar cutar.

A matsayinka na doka, ana gudanar da s / c minti na 15-20 kafin cin abinci. Ana canza wuraren allurar a kowane lokaci. Idan ya cancanta, ana ba da izinin IM ko IV.

Za a iya haɗe shi da insulins masu aiki da dogon lokaci.

Side sakamako

Allergic halayen: urticaria, angioedema, zazzabi, ƙarancin numfashi, rage karfin jini.

Daga tsarin endocrine: hypoglycemia tare da bayyanannun abubuwa kamar pallor, karuwar gumi, palpitations, damuwa na bacci, tashin hankali, raunin jijiyoyin jiki, halayen-rigakafi tare da insulin na mutum, karuwa a titin na anti-insulin rigakafi tare da karuwa mai zuwa na glycemia.

Daga gefen kwayoyin hangen nesa: raunin gani na lokaci (yawanci a farkon farji).

Abubuwan da suka shafi gida: hyperemia, itching da lipodystrophy (atrophy ko hauhawar mai mai subcutaneous) a wurin allurar.

Sauran: a farkon jiyya, ana iya haila (wuce tare da ci gaba da jiyya).

Haihuwa da lactation

A lokacin daukar ciki, ya zama dole a la’akari da raguwar buƙatar insulin a cikin farkon farkon ko ƙaruwa a cikin na biyu da na uku. Lokacin kuma kai tsaye bayan haihuwa, buƙatun insulin na iya raguwa kwatsam.

Yayin shayarwa, mai haƙuri yana buƙatar saka idanu na yau da kullun don watanni da yawa (har sai an daidaita ƙarfin buƙatar insulin).

Umarni na musamman

Tare da taka tsantsan, ana aiwatar da zaɓi na miyagun ƙwayoyi a cikin marasa lafiya da cututtukan ƙwayar cuta na ƙwaƙwalwar ƙwayar cuta na baya wadanda suka kasance a cikin nau'in ischemic kuma tare da nau'ikan cututtukan zuciya masu rauni.
Buƙatar insulin na iya canzawa a cikin waɗannan lambobin: lokacin da canzawa zuwa wani nau'in insulin, lokacin canza abinci, zawo, amai, lokacin canza yanayin da ya saba da aiki na jiki, a cikin cututtukan da kodan, hanta, pituitary, glandar thyroid, lokacin canza wurin allura.
Ana buƙatar daidaita daidaituwa na insulin ga cututtukan cututtukan, cututtukan thyroid, cutar Addison, hypopituitarism, gazawar koda, da kuma ciwon sukari a cikin marasa lafiya fiye da shekaru 65.

Canza haƙuri ga insulin ɗan adam ya kamata koyaushe a tabbatar da gaskiya kuma ana aiwatar da shi kawai a ƙarƙashin kulawar likita.

Abubuwan da ke haifar da rashin jini a cikin jiki na iya zama: insulin overdose, maye gurbin miyagun ƙwayoyi, tsallake abinci, amai, gudawa, damuwa ta jiki, cututtukan da ke rage buƙatar insulin (cututtukan koda da hanta, da hauhawar jini a cikin adrenal cortex, pituitary ko thyroid gland shine yake, canjin wurin allura) (alal misali, fata akan ciki, kafada, cinya), haka kuma ma'amala da wasu kwayoyi. Zai yiwu a rage taro na glucose a cikin jini yayin canja wurin mai haƙuri daga insulin dabbobi zuwa insulin ɗan adam.

Yakamata a sanar da mara lafiyar game da alamomin yanayin rashin haihuwa, game da alamun farko na rashin lafiyar masu cutar sankara da kuma game da bukatar sanar da likita game da duk canje-canje a yanayinsa.

Idan akwai matsalar hypoglycemia, idan mara lafiyar yana da hankali, an wajabta masa dextrose a ciki, s / c, i / m ko iv allura glucagon ko iv hypertonic dextrose. Tare da haɓakar ƙwayar ƙwayar cuta na jini, 20-40 ml (har zuwa 100 ml) na maganin 40% dextrose ana shigar da shi cikin rafi har sai mai haƙuri ya fito daga cikin warin.

Marasa lafiya da ciwon sukari na iya dakatar da ɗan ƙaramin ƙin jini na jini da suke ji ta wurin cin sukari ko abinci mai cike da ƙwayoyin carbohydrates (ana ba da shawarar marasa lafiya koyaushe a kalla 20 g sukari tare da su).

Rage shan giya a cikin marasa lafiya da ke karɓar insulin ya ragu.

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa

Halin da ake samu na haɓaka hypoglycemia na iya lalata iyawar marasa lafiya don tuki motocin kuma suna aiki da hanyoyin.

Hulɗa da ƙwayoyi

Tasirin hypoglycemic yana haɓaka ta hanyar sulfonamides (gami da magungunan maganin hypoglycemic na baki, sulfonamides), MAO inhibitors (ciki har da furazolidone, procarbazine, selegiline), inhibitors na carbonic anhydrase inhibitors, ACE inhibitors, ACE inhibitors, NSAIDs (gami da salicylides), anabolic (ciki har da stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, shirye-shiryen lithium, pyridoxine, quinidine, quinine, chlo, chlo, etin, chlo

Glucagon, GCS, histamine H 1 recepor blockers, maganin hana haihuwa, estrogens, thiazide da "madauki" diuretics, jinkirin tashar alli, mai juyayi, hormones thyroid, maganin tricyclic antidepressants, heparin, morphine diazropin rage tasirin hypoglycemic sakamako , marijuana, nicotine, phenytoin, epinephrine.

Beta-blockers, reserpine, octreotide, pentamidine duka zasu iya haɓaka da rage tasirin hypoglycemic na insulin.

Amfani guda daya na beta-blockers, clonidine, guanethidine ko reserpine na iya rufe alamun hypoglycemia.

Magunguna ba tare da maganin wasu magunguna ba.

Tsarin saki, abun da aka shirya da marufi

Akwai shi a cikin nau'i uku:

1. P - gajere mai aiki, mara launi da kuma amintaccen bayani.
2. C - matsakaici na tsawon lokaci, dakatarwar farin ko launin milky.
3. M - haɗa 30/70, kashi biyu. Matsakaici tare da saurin farawa na sakamako, dakatarwa.

Haɗin ya haɗa da:

• 100 IU na insulin injinin ɗan adam,
• furotin sulfate,
• sodium hydrogen phosphate foda,
• babbar murya,
• metacresol
• glycerol (glycerin),
• ruwa don yin allura.

Wadanda suka yi fice a cikin kayan suna da ɗan bambanci ga kowane nau'in. Rosinsulin M ya ƙunshi insulin biphasic - mai narkewa + isophane.

Ana samunsa a cikin kwalabe (guda 5 na 5 ml) da kuma katako (5 guda 3 na ml).

Pharmacokinetics

Nau'in P ya fara aiki rabin sa'a bayan allura, ganiya - 2-4 awanni. Tsawon lokaci har zuwa 8 hours.

Nau'in C an kunna bayan sa'o'i 1-2, ganiya yana faruwa tsakanin 6 da 12. Tasirin yana ƙarewa a rana.

M fara aiki a cikin rabin sa'a, ganiya shine 4-12, aikin ya ƙare a cikin sa'o'i 24.

An lalata shi ta hanyar insulinase a cikin kodan da hanta. Kodan ya fice. Abubuwan da ke cikin subcutaneous kawai ana ba su izinin kansu.

• Dukkan nau'ikan ciwon sukari
• Ciwon sukari a cikin mata masu juna biyu,
• Cututtukan ciki
• Addiction zuwa na baka hypoglycemic magunguna.

Umarnin don amfani (hanya da sashi)

Babban hanyar gudanarwa shine allurar subcutaneous. An zabi sashi daban-daban bisa shaidar da kuma bukatun jikin mutum. Wurin allurar shine kwancen kafa, kwatangwalo, ciki, kafada. Kullum ka canza wurin allurar.

Matsakaicin kullun shine 0.5-1 IU / kg.

Ana amfani da "Rosinsulin R" rabin sa'a kafin abinci. Yawan allurar yana da likitan likita ya umarta.

Side effects

• Abubuwan ƙetare na gida da na sihiri,
• Hypoglycemia,
• M da hankali har zuwa hauhawar jini,
• Rage saukar karfin jini
• Hyperglycemia da ciwon sukari acidosis,
• Increaseara yawan abubuwa masu mahimmanci na anti-insulin, yana ƙaruwa da karuwa a cikin glycemia,
• Rashin gani
• Abubuwan da ke tattare da illa da insulin na mutum,
• Hyperemia,
• Lipodystrophy,
• Kwari.

Yawan damuwa

Wataƙila ci gaban hypoglycemia. Alamomin ta: yunwar, pallor, ƙarancin sani zuwa ƙwayar cuta, tashin zuciya, amai da sauran su. Za'a iya cire fom ɗin haske ta cin abinci mai dadi (alewa, ɗan sukari, zuma). A cikin nau'i na matsakaici da mai tsanani, za a buƙaci allura ta glucagon ko wani bayani na dextrose, bayan - abinci tare da carbohydrates. Tabbatar sannan a nemi likita don daidaitawar kashi.

Kwatanta tare da analogues

Rosinsulin yana da nau'ikan kwayoyi masu kama da juna, waɗanda suke da amfani don fahimtar kanku da su don kwatanta kaddarorin.

Nuwammar. Insulin kewayawa, kashi biyu. Masana'antar Novo Nordisk ce ke Denmark. Farashin - har zuwa 1500 rubles. don shiryawa. Tasirin lokacin matsakaici, yana da sauri da tasiri. Ba a yarda da miyagun ƙwayoyi ga yara 'yan ƙasa da shekaru 6 ba, kuma an umurce shi da taka tsantsan yayin daukar ciki da tsufa. Ana lura da rashin lafiyar koda a farfajiyar allurar.

"Insuman." Insulin ɗan adam, abubuwa iri uku. Kudinsa daga 1100 rubles. Mai samarwa - "Sanofi Aventis", Faransa. Ana amfani dashi don maganin tsofaffi da yara. Da wuya haifar da sakamako masu illa. Abokin aikin kirki.

"Protafan." Hakanan insulin ɗan adam wani nau'in injiniyan ɗan adam ne. Mai rahusa - 800 rubles. don katako, bayani - 400 rubles. Kamfanin Novo Nordisk, Denmark ne ya ƙera. Ana sarrafa shi kawai a ƙarƙashin ƙasa, ana amfani dashi don kula da marasa lafiya na kowane zamani. Yana yiwuwa mata masu juna biyu da masu shayarwa. Counterpartarancin kuɗi mai araha da araha.

"Biosulin." Isulin insulin. Mai kera - Pharmstandard, Rasha. Kudin ya kusan 900 rubles. (katako). Lokaci ne na matsakaici. Ana iya amfani da shi don kula da marasa lafiya na kowane zamani.

Humulin. Inulin ne mai inginin injin-inuwa. Farashi - daga 500 rubles. ga kwalabe, katako mai tsada sau biyu. Kamfanoni guda biyu suna samar da wannan magani nan da nan - Eli Lilly, Amurka da Bioton, Poland. Amfani da shi don kowane rukunin shekaru, a cikin mata masu juna biyu da masu ciwon sukari. Yakamata a yi amfani da tsofaffi da hankali. Akwai shi a cikin magunguna da kuma fa'idodi.

Shawarwarin canja wurin mara lafiya daga wani nau'in magani zuwa wani shine wanda likitan halartar yake. An haramta shan magani!

Ainihi, masu ciwon sukari tare da gogewa kan wannan magani suna da ingantaccen ra'ayi. Sauƙin amfani, an lura da ikon haɗa nau'ikan da yawa. Amma akwai mutanen da wannan maganin bai dace da su ba.

Galina: “Ina zaune a Yekaterinburg, ana yi mani jinyar cutar sankara. Kwanan nan, Na karɓi Rosinsulin don fa'idodi. Ina son miyagun ƙwayoyi, da tasiri sosai. Ina amfani da gajeru da matsakaici, komai ya dace. Lokacin da na gano cewa wannan magani ne na gida, na yi mamaki. Ingancin ba zai iya bambancewa daga kasashen waje ba ”.

Victor: “Protafan ya kula da ni. Likitan ya ba da shawarar karin magungunan Rasha masu tsada, Rosinsulin. Na kasance ina amfani da shi tsawon watanni yanzu, Ina farin ciki da komai. Sugar yana riƙewa, babu sakamako masu illa, baya haifar da ƙwanƙwasa jini. Kwanan nan, na fara samun fa'idodi, wanda yake da daɗi sosai. ”

Vladimir: “Humalog” da “Humulin NPH.” A wani matsayi, Rosinsulin ya maye gurbinsu don fa'idodi. Ina amfani da gajere da matsakaici. Don gaya muku gaskiya, ban lura da bambance-bambance na musamman ba daga magungunan da suka gabata. Sugar yana da kyau, babu hypoglycemia. Koda ƙididdigar tantancewa ta yi kyau. Don haka ina ba da shawara ga wannan magani, kada ku ji tsoro cewa Rashanci ne - kayan aiki da albarkatun ƙasa, kamar yadda likitancina ya faɗi, baƙi ne, duk abin da ke cikin ka'idoji ne. Kuma tasirin hakan yafi kyau. "

Larisa: “Likitan ya koma Rosinsulin. Anyi maganin shi tsawon watanni, amma a hankali gwaje-gwajen sun zama mafi muni. Hatta abincin bai taimaka ba. Dole ne in canza zuwa wata hanyar, ba don fa'idodi ba, amma don kuɗi na. Abin kunya ne, saboda magani mai araha ne kuma yana da inganci. "

Anastasia: “Rijista da ciwon sukari. Sun ba da Rosinsulin tasirin matsakaici azaman magani. Short ta amfani da Actrapid. Na ji daga wasu cewa yana taimaka sosai, amma a gida ban sami wani canji na musamman a cikin jihar ba. Ina so in tambayi likita don canja wurin zuwa wani magani, saboda kwanan nan akwai ma wani harin hypoglycemia. Wataƙila shi bai dace da ni ba, ban sani ba. ”