Biosulin N: umarnin don amfani

Insulin Biosulin ne adam wata insulinwanda aka samu ta hanyar fasahar sabulu DNA. Akwai iri uku bioinsulin: 30/40 (biphasic), mai yin matsakaici da aiki mai gajere. Duk nau'ikan asalin inulin na inulin hulɗa tare da mai karɓar sel membrane kuma ya samar da hadaddun. Yana karfafa tafiyar matakai na ciki da hada kwayar enzymes. Rage yawan glucose yana da alaƙa da haɓakawa a cikin ƙwaƙwalwar shi.

Biosulin N yana da tsawon lokacin aiki. Bayanin ayyukansa yana ƙarƙashin mahimman canji ko da a cikin mutum guda. Tare da allurar subcutaneous, ana lura da fara aikin bayan kimanin sa'o'i 1-2, bayan awa 5 da 12 ana samun sakamako mafi girman, kuma tsawon lokacin aikin ya bambanta tsakanin awanni 19 zuwa 24.

Biosulin P yana da ɗan gajeren sakamako. Tare da allurar subcutaneous, tana aiki bayan minti 30, matsakaicin sakamako yana cikin awanni 2-4, kuma tsawon lokacin shine 7-8.

Alamu don amfani

• insulin dogaro ciwon sukari mellitus (nau'in 1)
• insulin mai zaman kanta ciwon sukari mellitus (nau'in 2) tare da tsayayya da wakilai na baka, yayin haɗuwa tare da cututtukan cututtukan zuciya.

Amfani da Biosulin P Hakanan an nuna shi don yanayin gaggawa tare da decompensated ciwon sukari.

Side effects

• swearin yin gumi, pallor, ciwon kai, palpitations, yunwa, rawar jiki, paresthesiafarin ciki
• rashin lafiyar hailala,
• Harshen Quincke's edemafata tayi amafflactic rawar jiki,
• kumburi,
• rikicewar tunani
• hyperemia a wurin allurar lipodystrophy (tare da amfani da tsawan lokaci).

Biosulin, umarnin don amfani (Hanyar da sashi)

Ana amfani da biosulin N don gudanar da aiki a ƙarƙashin ƙasa. Anyi amfani dashi shi kadai ko a hade tare da wasu. insulin. Ana yin amfani da maganin ne ta hanyar likita. Matsakaicin kullun shine 0.5 zuwa 1 IU a kowace kilogiram na nauyi. Mafi sau da yawa, ana yin allura a cinya ko bangon ciki na ciki. Don hana bayyanar lipodystrophy, kuna buƙatar canza wurin allurar.

Ana gudanar da biosulin P a karkashin subcutaneously, intramuscularly da intravenously. Ana kuma kirga matsakaita na yau da kullun. An gabatar da minti 30 kafin cin abinci.

Tare da monotherapy, ana gudanar da maganin a cikin sau 3 a rana (wani lokacin 6). Mai haƙuri yana yin allurar bututun kansa da kansa, kuma ana yin allura ta ciki da jijiyoyin jini a cikin cibiyoyin likitoci ne kawai a ƙarƙashin kulawar likita. Ana yin gyaran fuska don kamuwa da cututtuka, zazzabi, kafin tiyata, kamar yadda kuma tare da gagarumin ƙaruwa a cikin aikin jiki. Canji daga wannan magani zuwa wani ana aiwatar dashi karkashin kulawar sukari na jini.

Duk magungunan suna allura tare da sirinji na insulin, kuma alkalami mai ɗaukar sinadarin biosulin yana ba ku damar amfani da katangar mil 3 kawai. A wannan yanayin, kuna buƙatar amfani da alkalami mai sirinji Al'adun Batsa kuma yin matuƙar bi umarnin don amfanin sa. Katin an yi niyya don amfanin mutum ne kawai kuma kar a cika.

Yawan damuwa

Yana bayyana kanta a matsayin yanayin hypoglycemic: karuwar gumi, pallor, palpitations, yunwa, rawar jiki, paresthesiafarin ciki ciwon kai. A wasu halaye na tasowa rashin lafiyar hailala.

Sauki mai sauki yawan haila ya ƙunshi ɗaukar sukari, shayi mai zaki ko abubuwan carbohydrate (Sweets, cookies, Sweets). A lokuta masu tsauri (coma) maganin allurar 40% dextrose cikin intravenia, da subcutaneously - glucagon. Bayan mai haƙuri ya dawo da hankali, suna ba da shawarar shan abincin carbohydrate.

Haɗa kai

Tasirin miyagun ƙwayoyi yana haɓaka ta: wakilai na maganin ƙwaƙwalwa na baka, mahaɗa monoamine oxidasecarbonic anhydrase angiotensin yana canza enzymesulfonamides, ba zaɓaɓɓu ba masu hana beta, octreotide, bromocriptinemagungunan anabolic steroid Clofibrate, karafarini, ketoconazole, pyridoxine, karafarini, akarijin, fenfluramine, shirye-shiryen lithium, ethanol.

Tasirin maganin yana raunana ta: glucocorticosteroidsmaganin hana haihuwa heparinkarin bayani maganin tricyclic maganin alada, danazol, clonidine, tausayi, hanyoyin tallata alli, ƙwayar cuta, phenytoin, diazoxide, nicotine. Lokacin amfani madarar ruwa da salicylates duk raunana da fadada tasirin an lura dasu.

Nunawa game da biosulin

Da miyagun ƙwayoyi na zabi a cikin lura da marasa lafiya tare da SD ne kwayoyin inginin mutumin da ya yi daidai da tsarin sunadarai ga ɗan adam. A cewar Diungiyar Ciwon Cutar Cutar ta Duniya, waɗannan kawai insulin aiwatar a duk faɗin duniya. Amfaninsu shine inganci da aminci, dangane da abin da Ma'aikatar Lafiya na Federationungiyar Rasha ta ba da shawarar amfani da matasa, yara da mata masu juna biyu don neman magani. Sakamakon binciken irin waɗannan magungunan ya nuna cewa abun ciki na enzymes hanta, lipids, nitrogen saura, creatinine urea ya kasance a cikin iyakokin al'ada yayin amfanin su. Babu wanda ya taɓa jin rashin lafiyar halayen.

Wani fa'ida (wannan ya shafi tsawan lokacin shiri) shine cewa ana amfani da furotin a matsayin mai tsawa. protamine (ake kira NPH insulin), ba zinc. NPH insulin za a iya haɗu da shi tare da kwayoyi masu gajeriyar magana a cikin sirinji ɗaya kuma wannan ba zai haifar da canji a cikin kantin magani ba. Duk da duk fa'idodin, akwai ra'ayoyi marasa kyau kuma yawancin marasa lafiya sun fi son magunguna da aka shigo da su (Humalogue, NovoRapid).

• «... Na tsawon shekaru ina bin sa dashi. Komai yayi kyau, amma ina tsammanin babu wani abu da ya fi Humalog kyau».
• «... Kaka akan Biosulin. Ana iya rama sukari, amma hangen nesa da ƙafar ciwon sukari».
• «... kwanaki da yawa ina kan sa. An kawota a asibitin. Ya yi muni - sukari na 20! Ba ya taimaka!».
• «... Da kaina, Biosulin N baya taimako, kuma Biosulin P yayi kyau».

Formaddamar da tsari da abun da ke ciki na ƙwayoyi

Magungunan Biosulin N yana samuwa a cikin nau'i na dakatarwa wanda aka yi nufin gudanar da aikin subcutaneous a cikin 5 da gilashin gilashin gilashi bayyananne.

Babban kayan aiki na maganin shine insulin kwayoyin halittar mutum 100 IU. Hakanan magungunan sun ƙunshi abubuwan taimako: ruwa don yin allura, sinadarin zinc, sinadarin hydrogen phosphate, glycerol.

Kayan magunguna na maganin

Biosulin H shine insulin mutum, wanda aka samu ta hanyar fasaha ta hanyar amfani da DNA na mutum. Wannan kayan aikin yana da tasirin warkewa na tsawon lokacin matsakaici. Shiga cikin amsawar, ƙwayar ta samar da hadaddun insulin-receptor wanda ke nufin haɓaka hanyoyin kwantar da hankali. A ƙarƙashin tasirin miyagun ƙwayoyi, an rage matakin glucose a cikin jini da ƙimar samar da glucose ta hanta.

An nuna tsawon lokacin maganin yana maganin rage yawan ƙwayoyi, wanda kuma ya dogara da yawa akan hanyar gudanar da miyagun ƙwayoyi da wurin allurar.

Bayan gabatarwar Biosulin N a karkashin fata, ana lura da farkon tasirin warkewa bayan sa'a 1, ana samun girman sakamako bayan sa'o'i 5-10, jimlar lokacin aiki shine kusan awanni 18-20.

Yawan shan ƙwayoyi da farkon tasirin sa warkewa ya dogara da wurin gudanar da insulin (cinya, ciki, gindi), kashi na maganin da kuma haɗarin insulin a cikin kwalbar. Bayan gudanarwa a karkashin fata, ba a rarraba magunguna a ko'ina cikin kyallen takarda. Insulin baya ketare shinge na mahaifa zuwa tayin kuma zuwa cikin nono. An cire ta ta hanyar hanta a zahiri.

Alamu don amfani

An tsara maganin miyagun ƙwayoyi Biosulin N ga marasa lafiya a irin waɗannan halayen:

• Type 1 ciwon sukari mellitus,
• Nau'in marassa lafiya guda biyu wanda ba shi da insulin-insulin-mellitus - tare da haɓaka yanayi na jaraba ga wasu kwayoyi waɗanda ke rage matakin glucose a cikin jini don amfani da baki.

Sashi da gudanarwa

Magungunan Biosulin N an yi shi ne don gudanarwa ƙarƙashin fata. Ga kowane haƙuri, likita ya zaɓi mahimmancin sashi mai mahimmanci a cikin tsari mai daidaitaccen tsari. Ya dogara da matakin glucose a cikin jini, tsananin tsananin yanayin aikin, nauyin jikin mutum, shekaru da kuma halayen jikin mai haƙuri. Matsakaicin matsakaita na yau da kullum na miyagun ƙwayoyi ga marasa lafiya da ciwon sukari sun kasance daga nauyin 0,5 zuwa 1 IU / kg.

Kafin gabatar da miyagun ƙwayoyi a karkashin fata, ya kamata a sanya murfin a cikin zafin jiki zuwa ɗakin zazzabi, riƙe da vial na mintoci kaɗan a hannunka.

A mafi yawancin lokuta, an allurar da maganin a karkashin fata zuwa cinya, amma saboda wadannan dalilai, zaku iya amfani da bangon ciki na gaba ko buttock. Wani lokacin magani yana shiga cikin kafada. Dangane da umarnin, wurin allurar a karkashin fata dole ne a canza shi kullun, tunda allurar insulin a wuri guda na iya haifar da rage kiba mai ƙona kitse. Ana iya amfani da Biosulin N a matsayin magani mai zaman kanta ko kuma hade da Biosulin P - magani ne na tsawan lokaci.

Umarni na musamman

Ba za a iya amfani da Dakatarwar Biosulin N ba don allurar idan, bayan girgiza kwalbar da sauƙi, abubuwan da ke cikin sa ba su yi fari ko launin girgije ba. A lokacin amfani da wannan magani, marasa lafiya suna buƙatar kulawa da matakin glucose a cikin jini akai-akai.

Tare da mai zaman kanta na maye gurbin wannan magani tare da analogues, mai haƙuri na iya haɓaka yanayin hypoglycemia (raguwa a cikin glucose jini). Yawan yawan insulin yawan ruwa, yawan tsallakewar abinci, zawo ko amai mara nauyi, yawan motsa jiki ko matsanancin damuwa na iya haifar da ci gaban irin wannan yanayin. Hypoglycemia na iya haɓaka a cikin marasa lafiya dangane da yanayin da aka zaɓi wurin da ba daidai ba ko kuma idan aka haɗu da wasu magunguna.

Selectedarancin da ba a zaɓa ba yadda ya kamata a cikin shirin insulin a cikin marassa lafiya da ke ɗauke da cutar guda 1 irin ta mellitus, da kuma dogon hutu tsakanin allurar Biosulin, na iya haifar da haɓaka yanayin haɓaka jini (haɓaka hawan jini). Tare da haɓaka wannan yanayin, mai haƙuri ya haɗu da alamun bayyanar cututtuka a cikin 'yan sa'o'i kaɗan:

• Thirstara yawan ƙishirwa
• Yawan urination da yawan fitsari a rana (a wasu marassa lafiya har zuwa lita 10 a rana),
• Dizziness
• Bakin bushewa
• Appara yawan ci
• Kamshin da soaked apples daga bakin (ƙanshi na acetone).

Ci gaban hyperglycemia a cikin marasa lafiya da nau'in ciwon sukari na 1 na iya haifar da ketoacidosis mai ciwon sukari mai narkewa da coma na hyperglycemic.

Dole ne a daidaita kullun wannan maganin don marasa lafiya fiye da shekaru 65, da kuma marasa lafiya da cututtukan thyroid. Ana buƙatar gyaran gyaran ƙwayoyi don marasa lafiya tare da karuwa da yawaitar ayyukan jiki ko haɓaka rikice-rikice daga hanta da kodan.

A yayin cututtukan cututtuka da yanayin febrile, mai haƙuri yana buƙatar sake duba adadin yau da kullun na Biosulin N, dangane da gwajin jini.

Sauyin daga insulin shiri zuwa wani yakamata a gudanar dashi kawai a karkashin kulawa likita!

Side effects da yawan shan magani

Tare da madaidaicin kashi, likitan yana haƙuri da haƙuri sosai. Tare da ko da increasean ƙarami mai zurfi a sashi, mai haƙuri na iya haɓaka irin waɗannan sakamako masu illa:

• Gumi mai sanyi
• Rashin rauni da danshi,
• Yanayin jihar
• Palpitations,
• Hannun girgiza
• Pallor na fata
• Yunwar
• Halin "creeps creeps."

Tare da yawan shan magungunan ƙwayar cuta, mai haƙuri na iya haɓaka cutar mahaifa.

A cikin halayen da ba kasafai ba, tare da rashin hankalin mutum ga miyagun ƙwayoyi, mai haƙuri na iya haɓaka halayen fata na rashin lafiyan fata a cikin nau'in cutar urticaria, fitsari, edema na Quincke Tare da gabatarwar kullun na insulin a wuri guda, mai haƙuri yana haɓaka lipodystophia.

Amfani da magani yayin daukar ciki da shayarwa

Za'a iya amfani da magungunan Biosulin N don magance cututtukan ƙwayar cuta a cikin mata masu juna biyu da uwaye masu shayarwa. Da farawar ciki, mace ba ta buƙatar dakatar da gudanar da maganin ba, amma an ba da shawarar a nemi likita don daidaita maganin yau da kullun, wanda yana iya buƙatar ƙara ƙarancin kaɗan saboda karuwa a kan nauyin jikin da tsarin mai haƙuri.

Yanayin isar da magani da ajiyar magunguna

Ana bayar da maganin Biosulin N a cikin magunguna ta hanyar takardar sayan magani. Dole ne a adana maganin a cikin firiji a zazzabi da bai wuce digiri 8 ba. Ba a yarda daskarewa da vials ba.

Ya kamata a adana kwalban da ya buɗe a zazzabi da bai wuce digiri 20 ba tsawon watanni 1.5. Adana vials a wuri mai duhu, nesa da yara. Rayuwar shiryayye na miyagun ƙwayoyi shine shekaru 2 daga ranar da aka ƙera.

Hanyar amfani da biosulin N ta hanyar dakatarwa

Targetoƙarin maida hankali a cikin glucose a cikin jini, shirye-shiryen insulin da za ayi amfani da shi, insulin dosing regimen (kashi da lokacin gudanarwa) dole ne a ƙaddara kuma a daidaita daban-daban don dacewa da abincin, matakin motsa jiki da salon rayuwar mai haƙuri.

Magungunan Biosulin® N an yi nufin shi ne don gudanar da tsarin mulki. Ana amfani da maganin ne ta hanyar likita kwata-kwata a kowane yanayi dangane da tattarawar glucose a cikin jini. A matsakaici, kashi na yau da kullum na miyagun ƙwayoyi ya tashi daga 0.5 zuwa 1 IU / kg nauyin jikin mutum (ya dogara da yanayin halayen mutum na haƙuri da haɗuwa da glucose jini).

Dole ne likita ya ba da umarni da suka wajaba a kan sau da yawa don tantance yawan glucose a cikin jini, haka nan kuma ya ba da shawarwarin da suka dace idan akwai wani canje-canje a cikin abinci ko a cikin tsarin insulin.

A cikin lura da mummunan hyperglycemia ko, musamman, ketoacidosis, gudanarwar insulin wani ɓangare ne na ingantaccen tsarin kulawa wanda ya haɗa da matakan kare marasa lafiya daga mummunan rikice-rikice sakamakon raguwar hanzarin ƙwayar jini. Wannan tsarin kulawa yana buƙatar saka idanu sosai a cikin sashin kulawa mai zurfi (ƙayyade halin rayuwa, ma'aunin acid-base da daidaita ma'aunin lantarki, saka idanu mahimman alamun jiki).

Sauyawa daga wani nau'in insulin zuwa Biosulin® N

Lokacin canja wurin marasa lafiya daga irin insulin zuwa wani, ana iya buƙatar gyaran insulin tsarin insulin: alal misali, lokacin da aka sauya daga insulin dabbobi da aka samu zuwa insulin na mutum, ko lokacin da sauya sheka daga shirin insulin mutum zuwa wani, ko kuma lokacin juyawa daga tsarin insulin na mutum mai narkewa zuwa tsarin , gami da insulin aiki mai tsawo.

Bayan canzawa daga insulin dabbobi da aka samo zuwa insulin na mutum, yana iya zama dole don rage yawan insulin, musamman a cikin marasa lafiya waɗanda a baya suna da ƙananan haɓakar glucose na jini, a cikin marasa lafiya da haɓaka haɓakar haɓakar jini, a cikin marasa lafiya waɗanda suka buƙaci a farkon insulin allurai saboda tare da kasancewar ƙwayoyin cuta zuwa insulin.

Bukatar daidaitawa na kashi (raguwa) na iya tashi nan da nan bayan canzawa zuwa sabon nau'in insulin ko ci gaba a hankali akan makonni da yawa.

Lokacin canzawa daga wani nau'in insulin zuwa wani sannan kuma a cikin makonni na gaba masu zuwa, ana bada shawarar kulawa da hankali akan yawan glucose na jini.A cikin marasa lafiya waɗanda ke buƙatar insulin insulin masu yawa saboda kasancewar ƙwayoyin cuta, ana bada shawara don canzawa zuwa wani nau'in insulin a ƙarƙashin kulawar likita a asibiti.

Changearin canji a cikin insulin kashi

Inganta sarrafawa na rayuwa na iya haifar da karuwar hankali ga insulin, wanda hakan na iya haifar da raguwa a jikin mutum na bukatar insulin.

Hakanan ana iya buƙatar canjin kashi idan: canji a cikin nauyin jikin mai haƙuri, canji a rayuwar (gami da abinci, matakin motsa jiki, da sauransu) ko a wasu yanayi waɗanda zasu iya ƙara haɓakar yanayin hauhawar jini ko hyperglycemia (duba sashe "Umarni na Musamman" ").

Sashi na lokaci a cikin rukunan masu haƙuri

Tsofaffi marasa lafiya

A cikin tsofaffi, buƙatar insulin na iya raguwa (duba sassan "Tare da taka tsantsan", "Umarnin na musamman"). An ba da shawarar farawa na jiyya, haɓaka kashi da zaɓi na gwargwado na kulawa a cikin tsofaffi marasa lafiya da ke fama da cutar sukari mellitus tare da taka tsantsan don guje wa halayen haɗuwar jini.

Marasa lafiya tare da hepatic ko na koda kasawa

A cikin marasa lafiya da ke fama da hepatic ko na koda, ana iya rage buƙatar insulin.

Zazzabi na insulin da ke cikin yakamata ya zama zazzabi a dakin.

Ana amfani da miyagun ƙwayoyi Biosulin® N yawanci ana ƙarƙashin subcutaneously a cinya. Hakanan za'a iya yin allura a cikin bangon ciki na ciki, gindi ko kafada a cikin tsinkayar tsoka mai narkewa.

Wajibi ne a canza wurin allurar a cikin yankin na jiki don hana ci gaban lipodystrophy.

Tare da yin aiki da insulin ƙasa na insulin, dole ne a kula da kar a shigar da jini lokacin allura. Bayan allurar, bai kamata a sanyaya wurin da allura ba. Yakamata a horar da marassa lafiya yadda yakamata ayi amfani da na’urar insulin.

Shiri don gabatarwa

Lokacin amfani da miyagun ƙwayoyi Biosulin® N a cikin katako

Ridarfafawa tare da shirye-shiryen Biosulin® N kafin amfani yakamata a yi birgima a tsakanin tafin hannu a cikin wani wuri a kwance kuma ya girgiza don sake ɗaukar insulin har sai ya zama ruwa mai ruwa ko madara mai kama da juna. Bai kamata a kyale farji ya faru ba, wanda na iya tsoma baki tare da madaidaicin kashi. Wajibi ne a bincika katakan kayayyaki a hankali. Kada kuyi amfani da insulin idan ya ƙunshi flakes bayan haɗuwa, idan farin farin barbashi ya bi zuwa kasan ko ganuwar katun, yana ba da yanayin “yanayin sanyi”.

Na'urar katuwar katako ba ta bada izinin haɗa abubuwan da ke cikin su tare da wasu abubuwan insulins kai tsaye a cikin katun da kanta. Ba a cika cika abubuwan alaƙar katako ba.

Lokacin amfani da katako tare da alkalami mai warware warkarwa, umarnin mai siyayya don cika kwas ɗin cikin alƙalin syringe kuma yana ɗaukar allura ya kamata a bi. Ya kamata a gudanar da miyagun ƙwayoyi daidai da umarnin mai sana'anta don alkalami mai sikari.

Lokacin amfani da miyagun ƙwayoyi Biosulin® N a cikin alkalami na biomatikPen®2

Lokacin amfani da allurar sirinji na riga-kafin wanda za'a iya amfani dashi don maimaita injections, ya zama dole a haɗa dakatar da shirye-shiryen Biosulin in N a cikin sirinji nan da nan kafin amfani. Haɗin da aka haɗu da kyau ya kamata ya zama fari da gajimare.

Ba za a iya amfani da miyagun ƙwayoyi Biosulin® N a cikin sirinji mai ƙyalli idan ya daskare.

Lokacin amfani da alkalami na sikirin da aka cika dashi don maimaita alluran, ya zama dole don cire alkairin sirinji daga firiji kafin amfani na farko da bada izinin shirya ya kai zafin jiki na ɗakin. Dole a bi takamaiman umarnin don amfani da alkairin da aka bayar tare da miyagun ƙwayoyi.

Magungunan Biosulin® N a cikin sirinji da allura an yi niyya ne don amfanin mutum kawai. Kar a cika kwantar da sikirin. Kada a sake amfani da allura Don karewa daga haske, ya kamata a rufe alƙarin sirinji tare da hula. Karku ajiye firinjin da aka yi amfani dashi a cikin firiji.

Ana iya sarrafa kwayar ta Biosulin® N ko dai ita kaɗai ko a hade tare da insulin gajeriyar magana (ƙwayar Biosulin® P).

Gabaɗaya halaye. Abun ciki:

Abunda yake aiki: 100 IU na insulin injinin ɗan adam.

Wadanda suka kware: sinadarin zinc, sinadarin hydrogen phosphate, sinadarin protamine, metacresol, phenol, glycerol, ruwa don yin allura.

Lura Don daidaita pH, ana amfani da maganin sodium hydroxide 10% ko 10% hydrochloric acid solution.

Propertiesungiyoyin magunguna:

Pharmacodynamics Biosulin® N - an samu insulin na mutum ta amfani da fasahar DNA. Shiri ne na matsakaici wanda yake aiki da shi. Yana hulɗa tare da takamaiman mai karɓa a kan ƙwayar cytoplasmic na waje na sel kuma yana samar da hadaddun insulin-receptor wanda ke motsa ayyukan ciki, gami da haɗakar enzymes da yawa (hexokinase, pyruvate kinase, glycogen synthetase, da sauransu). Rage yawan glucose na jini ana faruwa ne ta hanyar karuwa a cikin jijiyoyin zuciya, karuwar sha da kuma rage kyallen takarda, haɓakar lipogenesis, glycogenogenesis, raguwa a cikin yawan samar da glucose ta hanta, da dai sauransu.

Tsawon lokacin aiwatar da shirye-shiryen insulin ya kasance ne sabili da yawan rashi, wanda ya dogara da dalilai da yawa (alal misali, akan kashi, hanya da wurin gudanarwar), sabili da haka bayanin aikin insulin yana haifar da sauyawa sosai, duka mutane daban-daban kuma a daya mutum ɗaya.

Bayanin aiki na allurar subcutaneous (kimanin ƙididdiga): farawar aiki bayan sa'o'i 1-2, mafi girman tasirin a tsakanin tsakanin 6 zuwa 12, tsawon lokacin aikin shine awoyin 18-24.

Pharmacokinetics Cikakken kamfani da kuma haifar da tasirin insulin ya dogara da wurin allura (ciki, cinya, buttocks), kashi (girman insulin allurar), yawan insulin a cikin magunguna, da dai sauransu An rarraba shi ba tare da bambanci ba a jikin kyallen, kuma ba ya shiga cikin shinge na mahaifa da kuma cikin madara. An lalata shi ta hanyar insulinase galibi a cikin hanta da kodan. Kodan ya fitar da ita (kashi 30-80%).

Siffofin Aikace-aikacen:

Yi amfani da lokacin daukar ciki da lactation. Babu ƙuntatawa game da lura da ciwon sukari mellitus tare da insulin a lokacin daukar ciki, tun da insulin bai ƙetare shinge na mahaifa ba. Lokacin da ake shirin daukar ciki da lokacin sa, ya zama dole a kara yin maganin cutar sankara. Bukatar insulin yawanci yana raguwa a farkon farkon ciki kuma sannu a hankali yana ƙaruwa a cikin na biyu da na uku.

Lokacin kuma kai tsaye bayan haihuwa, buƙatun insulin na iya raguwa kwatsam. Ba da daɗewa ba bayan haihuwa, buƙatar insulin ya koma matakin da ya kasance kafin yin juna biyu.

Babu ƙuntatawa game da lura da ciwon sukari mellitus tare da insulin yayin shayarwa. Koyaya, yana iya zama mahimmanci don rage adadin insulin, sabili da haka, saka idanu a hankali shima ya zama dole don watanni da yawa har sai an daidaita karfin insulin.

Kada ku yi amfani da Biosulin® N idan, bayan girgizawa, dakatarwar ba ta zama fari ba kuma gajimare.

Gabanin tushen ilimin insulin, lura da kullun matakan glucose na jini ya zama dole.

Abubuwan da ke haifar da hypoglycemia, ban da yawan wuce haddi na insulin, na iya zama: maye gurbin miyagun ƙwayoyi, tsallake abinci, amai, gudawa, yawan motsa jiki, cututtukan da ke rage buƙatar insulin (lalacewar hanta da aikin koda, hauhawar jijiyoyin jini, ƙwarya ko glandar thyroid), canjin wuri inje, da kuma hulɗa tare da wasu kwayoyi.

Rashin ingantaccen allura ko katsewa a cikin gudanarwar insulin, musamman a cikin marasa lafiya da ke dauke da ciwon sukari na 1, na iya haifar da cutar hauka. Yawancin lokaci, alamun farko na hyperglycemia suna haɓaka hankali a kan sa'o'i da yawa ko kwanaki. Waɗannan sun haɗa da ƙishirwa, yawan urination, tashin zuciya, amai, amai, ja, bushewar fata, bushewar baki, rashin ci, kamshin acetone a cikin iska mai ƙuna. Idan ba a kula da shi ba, zazzabin hyperglycemia a cikin nau'in 1 na ciwon sukari na iya haifar da haɓakar cutar ketoacidosis mai barazanar rayuwa.

Yankin insulin dole ne a gyara shi saboda aikin thyroid mai rauni, cututtukan Addison, cututtukan zuciya, hanta da ƙoshin koda da masu ciwon sukari a cikin mutane sama da shekaru 65 da haihuwa.

Hakanan ana iya buƙatar gyara kashi na insulin idan mai haƙuri ya ƙaru da ƙarfin motsa jiki ko ya canza abincin da aka saba.

Cututtukan da ke haɗuwa, musamman cututtuka da yanayi tare da zazzabi, suna ƙara buƙatar insulin.

Canjin daga wani nau'in insulin zuwa wani yakamata a gudanar dashi ƙarƙashin ikon matakan glucose na jini.

Miyagun ƙwayoyi na rage haƙuri haƙuri.

Sakamakon yiwuwar hazo a cikin wasu catheters, ba a bada shawarar yin amfani da miyagun ƙwayoyi a cikin farashin matatun.

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa. Dangane da babban dalilin insulin, canji a nau'ikansa ko kasancewar mahimman damuwa na jiki ko na tunani, yana yiwuwa a rage ikon hawa mota ko sarrafa abubuwa daban-daban, kazalika da shiga cikin wasu ayyukan haɗari masu haɗari waɗanda ke buƙatar haɓakar kulawa da saurin halayen tunani da motsa jiki.

Yanayin ajiya:

Lissafi B. A cikin duhu a zazzabi na 2 ° C zuwa 8 ° C. Kar a daskare. Adana vial da aka yi amfani da shi a zazzabi na 15 ° C zuwa 25 ° C na makonni 6. Adana kabad ɗin da aka yi amfani da shi a zazzabi na 15 ° C zuwa 25 ° C na tsawon makonni 4. Ayi nesa da isar yara. Rayuwar shelf shine shekaru 2. Kada kayi amfani bayan ranar karewa wanda aka nuna akan kunshin.

Yanayin hutu:

Dakatarwa ga subcutaneous management na 100 IU / ml.

5 ml ko 10 ml a kowace kwalban gilashin tsaka tsaki mara launi, an yi ɗamara tare da haɗin kai.

3 ml kowane a cikin katako wanda aka yi da gilashin tsaka tsaki mara launi, an ɗora shi tare da haɗin kai, don amfani tare da alkalami na ƙirar Biomatic Penmatic ko Biosulin® Pen. Kwallon da aka yi da gilashin borosilicate an saka shi cikin kicin.

1 vial na 5 ml ko 10 ml a kowace fakiti, tare da umarnin don amfani. Miliyan 2.3 ko 5 na 5 ml ko 10 ml a cikin bororo.

A akwatunan 1, 3 ko 5 a cikin kunshin ɗaukar hoto.

Kunshin kwano 1 tare da kwalabe ko katako a kowace fakitin, tare da umarnin don amfani.

Alamu, contraindications da sakamako masu illa

Alamar don amfani da samfurin magani shine kasancewar a jikin mai haƙuri na nau'in ciwon sukari na 1 na mellitus.

Ana amfani da miyagun ƙwayoyi don nau'in ciwon sukari na 2 na mellitus, wanda yake a mataki na jure magungunan hypoglycemic da aka dauka ta hanyar baki, a mataki na juriya ga magungunan baka yayin amfani dashi a cikin hadaddun farji, haka kuma yayin haɓaka cututtukan cututtukan cututtukan cuta na 2 na cututtukan mellitus.

Babban contraindications don amfani shine kasancewar ƙara yawan hankalin mutum ga insulin ko kuma wani sashi wanda shine ɓangaren na'urar kiwon lafiya da haɓaka alamun mai haƙuri yana da halin hypoglycemic.

Bayyanar sakamako masu illa daga amfani da kayan likita yana da alaƙa da tasirin ƙarshen a kan ayyukan metabolism metabolism.

Babban sakamako masu illa da ke fitowa a jikin mai haƙuri lokacin amfani da miyagun ƙwayoyi sune kamar haka:

1. Haɓakawa a cikin jikin yanayin rashin lafiya, wanda ke bayyana kanta a cikin bayyanar pallor na fata, ƙara haɓaka, haɓaka ƙoshin zuciya da kuma bayyanar tsananin ƙarfin jin yunwa. Bugu da kari, farin ciki da tsarin jijiyoyi da paresthesia a bakin ya bayyana; bugu da ,ari kuma, raɗaɗi mai zafi ya bayyana. Mai tsananin rashin ƙarfi na haifar da mutuwa.
2. Allergic halayen lokacin amfani da miyagun ƙwayoyi suna bayyana da wuya kuma galibi yakan faru ne a cikin fatar fatar akan fata, haɓakar edema na Quincke kuma a cikin yanayi mai wuya yanayin girgiza ƙwayar cuta mai tasowa.
3. Kamar yadda raunin da ya faru a cikin gida, hyperemia, kumburi da itching a cikin allurar ya bayyana. Tare da tsawaita amfani da miyagun ƙwayoyi, haɓakar lipodystrophy a cikin allurar yana yiwuwa.

Bugu da ƙari, bayyanar edema, da kurakurai masu raɗaɗi. Mafi sau da yawa, sakamakon da aka nuna na ƙarshe yana faruwa a matakin farko na far.

Umarnin don amfani da miyagun ƙwayoyi

Magungunan magani hanya ce don gudanar da aiki a ƙarƙashin ƙasa. Yawan likitan da ake buƙata don allura ya kamata ƙididdigar likita ta halarta.

Endocrinologist ne kawai ke iya yin lissafin kashi, wanda ake buƙata ya yi la'akari da yanayin jikin mutum da sakamakon gwaje-gwaje da binciken haƙuri. Sashi da aka yi amfani dashi don magani yakamata yayi la'akari da matakin glucose a jikin mai haƙuri. Mafi sau da yawa, ana amfani da miyagun ƙwayoyi a cikin sashi na 0.5 zuwa 1 IU / kg na nauyin jikin mai haƙuri.

Zazzabi da aka yi amfani da shi don gabatarwa cikin jikin samfurin ya kamata ya zama zafin jiki na dakin.

Dole ne ayi amfani da lissafin adadin magungunan a cikin cinya. Bugu da ƙari, ana iya gudanar da maganin a cikin subcutaneously a cikin yankin bangon ciki na ciki, gindi, ko kuma a yankin da ƙwayar tsohuwar ƙwayar cuta take.

Don hana lipodystrophy a cikin ciwon sukari na mellitus, ya zama dole don canza wurin allurar.

Ana iya amfani da Biosulin N duka a matsayin kayan aiki mai zaman kanta yayin lokacin insulin da kuma azaman ɓangaren ƙwaƙwalwa mai rikitarwa a cikin haɗin gwiwa tare da Biosulin P, wanda insulin gajere ne.

Bai kamata a yi amfani da miyagun ƙwayoyi don magani ba, bayan girgiza shi, dakatarwar ba ta sami farin tint ba kuma bai zama girgije mai ɗauka ba.

Game da amfani da wannan magani, yakamata a gudanar da aikin kulawa da matakan glucose din plasma a koda yaushe.

Abubuwan da suka haifar da haɓakar yanayin rashin ƙarfi a cikin jikin mai haƙuri na iya zama, ban da abin sama da ya kamata, waɗannan dalilai masu zuwa:

• maye gurbin magani
• take hakkin tsarin abinci,
• aukuwa na amai,
• abin da ya faru na zawo,
• da tanadi kan mai haƙuri na ƙara yawan aiki na jiki,
• cututtuka na shafar jikin mutum na buƙatar insulin,
• canjin yankin allura,
• hulɗa tare da wasu magunguna.

Tare da babban dalilin insulin, ba dole ne a gudanar da aikin abin hawa ba, tunda akwai yuwuwar yiwuwar raguwa a cikin yanayin mutum da raguwar ƙarancin gani.

Yanayin ajiya, farashi da kuma alamun magunguna

Ya kamata a adana miyagun ƙwayoyi a wurin da aka ba shi kariya daga haske, a zazzabi na 2 zuwa 8 digiri Celsius. Haramun ne a daskare na'urar likita.

Ya kamata a ajiye kwalban da aka buɗe da aka yi amfani da shi tare da na'urar likita a yanayin zafi a cikin kewayon daga digiri 15 zuwa 25 Celsius. Wannan umarnin insulin don amfani ya bayyana cewa rayuwar shiryayye na miyagun ƙwayoyi shine watanni shida. Lokacin amfani da miyagun ƙwayoyi a cikin kabad, rayuwar shiryayye daga cikin kundin da aka yi amfani da shi kada ya wuce makonni 4.

Ya kamata a adana magungunan a wani wuri wanda ba a isa ga yara.

Rayuwar shiryayye na kayan aikin likitanci shine shekaru 2. Bayan wannan lokacin, bai kamata a yi amfani da na'urar likita ba lokacin maganin insulin.

Ana bayar da maganin a cikin kantin magunguna ta hanyar takardar sayan magani.

Dangane da marasa lafiya da suka yi amfani da wannan nau'in insulin, hanya ce mai kyau don sarrafa matakin sukari a jikin mai haƙuri da ciwon sukari.

Analogues na miyagun ƙwayoyi sune:

1. Gansulin N.
2. Insuran NPH.
3. Humulin NPH.
4. Humodar.
5. Rinsulin NPH.

Kudin kwalba ɗaya a Rasha yana kan 500-510 rubles, kuma katako 5 tare da ƙara 3 ml kowane yana da farashi a cikin kewayon 1046-1158 rubles.

Bidiyo a cikin wannan labarin yayi magana game da aiki da halayen insulin.

Pharmacokinetics

Matsakaicin narkewa da farawa na ci gaban tasirin insulin ya dogara da girman insulin da aka gudanar, maida hankali sosai a wurin shiri da allurar kafa (cinya, cinya, buttock).

An rarraba hormone din ba daidai ba cikin kyallen takarda. Bai ƙetare katangar ƙwarya ba kuma cikin madara.

Isulin insulin yana cikin yawanci a hanta da kodan a ƙarƙashin rinjayar insulinase. An fitar dashi a cikin fitsari a cikin adadin 30 zuwa 80% na maganin.

Contraindications

• hawan jini,
• hypersensitivity ga insulin ko kowane bangare na dakatarwar Biosulin N.

Tare da taka tsantsan, ya kamata a yi amfani da miyagun ƙwayoyi a cikin waɗannan masu zuwa (ana buƙatar daidaita sashi):

• mai aiki mai ɗaukar hoto,
• aikin hanta mai rauni,
• kasancewar cutar kutse,
• mai ƙarfi jijiya na jijiya da jijiyoyin jini,
• haila,
• Cutar Addison
• kyakyawan magana,
• retinopathy na proliferative, musamman ma a cikin marasa lafiyar da basu taɓa jinyar laser (magani na photocoagulation),
• shekaru sama da 65 years.

Biosulin N, umarnin don amfani: hanyar da sashi

Targetoƙarin maida hankali ga glucose, tsari na dosing (kashi da lokacin gudanarwa) an ƙaddara kuma likita ya daidaita shi daban-daban ga kowane mara lafiya a cikin hanyar da zai dace da rayuwar mai haƙuri, matakin motsa jiki da abinci.

Ana dakatar da Biosulin N a karkashin hanya, yawanci a cinya. Hakanan za'a iya yin allurar a cikin kafada (a cikin tsinkayar tsoka mai ban sha'awa), bangon ciki na ciki ko gindi. Don guje wa haɓakar lipodystrophy, ana bada shawara don sauya wuraren allura a cikin yankin anatomical. Yakamata a gudanar da dakatarwar a hankali domin a hana shi shigar da jini. Babu buƙatar tausa wurin allurar.

Likita ya tsara adadin gwargwadon matakin glucose a cikin jini da kuma halayen mutum na mai haƙuri. Matsakaita na yau da kullun ya bambanta tsakanin 0.5-1 IU / kg.

Kowane mai haƙuri ya kamata ya koyar da shi ta hanyar ƙwararrun likitan likita game da yawan ƙayyadadden ƙwayar glucose da shawarwari dangane da tsarin kula da insulin a cikin yanayin kowane canje-canje a salon rayuwa ko abinci, kazalika da koyar da yadda ake amfani da na'urar don sarrafa Biosulin N.

A cikin ciwo mai raɗaɗi (musamman, tare da ketoacidosis), yin amfani da insulin wani ɓangare ne na cikakkiyar magani, gami da matakan kare marasa lafiya daga rikice-rikice masu yiwuwa saboda raguwar hawan jini a cikin sauri. Irin wannan tsarin kulawa yana buƙatar kulawa da hankali a cikin sashin kulawa mai zurfi, wanda ya haɗa da saka idanu mahimman alamun jiki, ƙayyade ma'aunin lantarki, daidaitaccen tushen acid, da kuma halin rayuwa.

Zazzabi na dakatarwar da aka gabatar ya kamata ya zama zazzabi dakin.

Haramun ne a gabatar da dakatarwa, idan bayan hadawa bai zama mai hade da juna ba, gajimare, fari. Kada ku yi amfani da samfurin idan, bayan haɗuwa, ya ƙunshi flakes, ko farin barbashi mai laushi da ke ƙasa / ganuwar kwalbar (tasirin “yanayin sanyi”).

Canji zuwa Biosulin N daga wani nau'in insulin

Lokacin canja mai haƙuri daga nau'in insulin zuwa wani, tsarin kulawa na ƙila zai iya buƙatar daidaitawa, alal misali, lokacin da ake maye gurbin insulin dabba-dabba da mutum, lokacin da canzawa daga insulin ɗan adam zuwa wani, lokacin canja wurin daga insulin ɗan adam zuwa insulin mai aiki mai tsayi, da dai sauransu.

Lokacin canzawa daga insulin dabbobi da aka samo zuwa insulin na mutum, yana iya zama dole don rage yawan maganin, musamman ga marasa lafiya waɗanda ke da haɗuwa da hypoglycemia, a baya sunada ƙarancin glucose a cikin jini, a baya suna buƙatar ɗimbin insulin na insulin yawa saboda kasancewar ƙwayoyin cuta a ciki.

Bukatar rage kashi na miyagun ƙwayoyi na iya tashi nan da nan bayan canja wuri zuwa sabon nau'in insulin, kuma ya inganta a hankali a cikin makonni da yawa.

Yayin sauya mai haƙuri zuwa wani shiri na insulin kuma a cikin farkon makonni na amfani da shi, ya kamata a sa ido sosai a cikin matakan glucose na jini. An ba da shawarar marasa lafiya waɗanda a da suka buƙaci babban allurai na insulin saboda kasancewar ƙwayoyin cuta don canzawa zuwa wani nau'in insulin daban-daban a asibiti a ƙarƙashin kulawar likita.

Changearin canji a cikin insulin kashi

Tare da ingantacciyar iko na rayuwa, haɓaka ƙwaƙwalwar insulin yana yiwuwa, sakamakon wanda za a iya rage buƙatarta.

Yin gyare-gyare na matsakaici na iya zama dole yayin sauya nauyin jikin mai haƙuri, salon rayuwa, ko wasu yanayi waɗanda zasu iya ƙara haɓakar yanayin haɓakar hauhawar jini ko hypoglycemia.

Ana buƙatar rage buƙatar insulin a cikin tsofaffi. Don guje wa halayen hypoglycemic, ana bada shawara don fara amfani da hankali tare da taka tsantsan, ƙara yawan sashi kuma zaɓi sigogin tabbatarwa.

Rage buƙatun insulin kuma ana ganin su sau da yawa a cikin matsalar koda / hanta.

Amfani da Biosulin N a cikin vials

Yin amfani da insulin guda ɗaya kaɗai:

1. Sanitize da membrane na roba akan kwafin.
2. Airara iska a cikin sirinji cikin ƙara wanda ya dace da yawan insulin ɗin da ake buƙata. Sanya shi a cikin kwalbar tare da magani.
3. Juya kwalban (tare da sirinji) juye kuma zana adadin dakatarwar da ake so a sirinji. Cire sirinji daga cikin kwalin kuma cire iska daga ciki. Bincika daidai gwargwado.
4. Cike kai tsaye.

Hada abubuwa guda biyu na insulin:

1. Cutar da membranes na roba akan kwalabe biyu.
2. Mirgine kwalban insulin aiki na dusar ƙanƙara (girgije) tsakanin tafin hannuwa har zuwa lokacin da miyagun ƙwayoyi ya zama mai haduwa da fari.
3. Lectara iska a cikin sirinji a cikin adadin daidai yake da adadin insulin na girgije, saka shi cikin murfin da ya dace kuma ɗaukar allura (ba kwa buƙatar tattara maganin har yanzu).
4. Airara iska a cikin sirinji a cikin adadin daidai yake da na insulin-ɗan gajeran aiki (m) kuma shigar da shi cikin murfin da ya dace. Ba tare da cire sirinji ba, juya kwalban a gefe kuma buga lambar da ake so. Cire sirinji daga cikin kwalin kuma cire iska daga ciki. Bincika daidai gwargwado.
5. Saka allura a cikin murfin insulin na gizagizai. Ba tare da cire sirinji ba, juya shi juye kuma buga lambar da ake so. Cire iska, bincika daidaituwar kashi.
6. Shigar da cakuda nan da nan.

Rubuta nau'ikan insulin ya kamata koyaushe ya kasance cikin tsarin da aka bayyana a sama.

Yin amfani da Biosulin N a cikin katako

An tsara katako don amfani dashi tare da alkalami na biosulin da sirinji na ƙirar halitta.

Kafin gudanarwa, mai haƙuri dole ne ya tabbata cewa katangar bata lalace (alal misali, fashe), in ba haka ba za'a iya amfani dashi.

Dole ne a haɗu da fitarwa nan da nan kafin allurar (kuma shigar da katun a cikin abin da aka sirinji): juya kabad ɗin sama da ƙasa a ƙalla sau 10 domin ƙwallon gilashi ya motsa daga ƙarshen zuwa ƙarshen kabad ɗin har sai dukkanin ruwan an cakuda shi daidai. Idan an riga an shigar da katun a alƙalin, juya shi tare da kicin. Wannan hanya yakamata ayi kafin kowace karamar hukuma ta Biosulin N.

Bayan an shigar da katun a cikin sirinji na siriri, za a ga takarda mai launi a jikin mai riƙe.

Kowane samfurin biosulin N shine don amfanin mutum kawai. Kar a cika kwantena.

Kafin yin allura, ya kamata ka wanke hannuwanka, kuma ka goge fatar a wurin allura tare da gogewar giya, amma bayan an saka kashi na insulin a cikin alkairin sirinji, sannan a bar barasa ya bushe.

Hanyar yin allurar Biosulin N da keɓaɓɓen alkalami:

1. Sami tarin fata tare da yatsunsu biyu kuma saka allura a cikin gindinta a kwana na 45 °, yi allurar insulin.
2. Yayin riƙe maɓallin ƙasa, bar allura a ƙarƙashin fata na akalla aƙalla 6 don tabbatar da ingantaccen tsarin kulawa da iyakance shigar jini / lymph cikin allura / kabad.
3. Cire allura. Idan jini ya tashi a wurin allura, a hankali shafa matattarar allurar tare da auduga wadda za ta narke tare da maganin mafitsara (kamar giya).

Hankali! Alluhun bakararre ne, kar a taba shi. Dole ne ayi amfani da sabon allura don kowane allura.

Yakamata mai haƙuri ya bi umarnin a cikin umarnin don amfani da takamaiman alkalami, wanda ya bayyana dalla-dalla yadda za a shirya shi, zaɓi sashi, gudanar da magani.