Kwayoyin cutar sankara na ciwon suga

Hanyar warkewa don nau'in ciwon sukari na 2 na mellitus an kafa shi ne ba kawai ga abinci na musamman ba, har ma a kan m na samfuran roba da suka dace da cutar.

Suna da mahimmanci don cimma dabi'un glycemic na al'ada.

Daga cikin magunguna da yawa da kasuwar magunguna ke bayarwa, galibi ana ba masu haƙuri allunan Glibomet.

Babban bayani game da magani, tsari na saki da abun da ke ciki

Glibomet yana cikin rukunin magungunan cututtukan cututtukan da ake ɗauka na baka. Kamfanin miyagun ƙwayoyi ne ya sanya shi daga kamfanin na Jamus BERLIN-CHEMIE / MENARINI. Baya ga Glibomet, a cikin Rasha fiye da 100 magunguna na wannan kamfani suna rajista, waɗanda ke amfani da karfi sosai don magance cututtuka da yawa kuma sun riga sun sami nasarar dogara da marasa lafiya.

Ana sayar da miyagun ƙwayoyi a cikin nau'i na allunan mai rufi da farin harsashi. Kowane ɗayansu ya ƙunshi kayan aiki guda 2 da ɗimbin yawa na abubuwan taimako.

Kwamfutar hannu na miyagun ƙwayoyi ya ƙunshi:

• Glibenclamide (2.5 MG) da Metformin Hydrochloride (400 MG) sune manyan abubuwan,
• sitaci masara (na gina jiki) - 57.5 MG,
• cellulose (polysaccharide shuka) - 65 MG,
• silicon dioxide (ƙarin abinci E551) - 20 MG,
• gelatin - 40 MG
• Glycerol - 17.5 MG,
• talc (ma'adinai) - 15 MG,
• Diethyl phthalate (0.5 mg) da 2 mg Acetylphthalyl cellulose - suna a cikin kwalin allunan.

Kunshin na iya zama allunan 40, 60 ko 100.

Pharmacology da pharmacokinetics

Godiya ga abubuwan haɗin da ke cikin shirye-shiryen, ƙwayar ta rage nuna alamar glucose a cikin jinin mai haƙuri.

Tsarin magunguna na abu Glibenclamide:

• yana ƙarfafa ƙwayar insulin, kuma yana ƙara ƙaddamar da ƙwayar,
• Yana ba da gudummawa ga karuwar kamuwa da insulin a cikin jikin mutum,
• yana haɓaka sakamakon insulin akan glucose,
• yana rage jinkirin aiwatar da aikin lipolysis.

Tsarin magunguna na Metformin:

• yana taimakawa haɓaka haɓakar insulin, kuma yana haɓaka sakamako,
• Yana rage shayewar glucose a cikin hanji, yana inganta yawanshi ta sauran gabobin,
• yana taimaka wa hana gluconeogenesis,
• yana da kyau yana shafar narkewar ƙwayar cuta, wanda ke haifar da asarar nauyi.

Zai yuwu a sami raguwa a cikin ƙwayar ƙwayar cuta bayan kwaya bayan awa 2 da adana don awa 12.

Tasirin magungunan ƙwayar cuta ta hanyar halayen shaƙa, rarrabawa, metabolism da maɗaukakkun abubuwan haɗin.

1. Tsotsa da tsarin rarraba. Matsakaicin maida hankali akan abubuwan ya kai 2 sa'o'i bayan gudanarwa. An tattara kayan cikin hanzari daga narkewa kamar jijiyoyi (gastrointestinal fili). Haɗin abu tare da furotin plasma ya kai 97%.
2. Tsarin metabolism yana faruwa kusan gaba ɗaya a cikin hanta.
3. Kiwo. Regulation na wannan aikin ana yin shi ta hanta. Ana fitar da exclave din din ne tare tare da fitsari da bile ta hanyar fitsari. Rabin-rai na awanni 10.

1. Shakarwa da rarrabewar a cikin kyallenyen bangaren yana faruwa da sauri da sauƙi.
2. Fitar abubuwan da ke jikin daga jikin mutum yana faruwa ne ba tare da ya canzawa ta hanjin koda da hanjinsa ba. Cire rabin rayuwar yana ɗaukar awoyi 7.

Alamu da contraindications don amfani

An ba da shawarar yin amfani da miyagun ƙwayoyi don amfani da ciwon sukari na 2, lokacin cin abinci da magani tare da wasu kwayoyi ba su da tasiri.

• rashin jituwa ga kowane ɓangare na magungunan,
• nau'in ciwon sukari guda 1
• ciwon sukari
• lactic acidosis,
• ketoacidosis
• coma (hypoglycemic ko hyperglycemic),
• matsanancin cutar koda,
• ilimin halittar hanta, hanta,
• 'yan ta'adda
• gaban da cututtuka,
• hanyoyin tiyata, tare da babban asarar jini,
• raunin da ya faru ko ƙonewa
• duk wani yanayin da ake bukatar amfani da maganin insulin,
• leukopenia
• porfria
• canje-canje dystrophic
• barasa maye,
• lokacin shayarwa,
• yara, matasa masu shekara 18,
• ciki

Umarnin don amfani da umarni na musamman

Ana ɗaukar allunan a baki tare da abinci. Dole ne likita ya zaɓa sashi na miyagun ƙwayoyi, yin la'akari da tsari na metabolism na carbohydrates da glycemia a cikin haƙuri.

Shan magani sau da yawa yana farawa da kwamfutar hannu ɗaya. Ya danganta da sakamakon far, magani na iya bambanta. Matsakaicin adadin izinin allunan a kowace rana shine 6, saboda yana da haɗari a ɗauka a cikin mafi girman sashi. Ingantaccen tsarin magani da aka zaɓa ana ƙaddara shi da ƙimar glucose da aka cimma.

Yana da mahimmanci ga marasa lafiya su bi shawarar likita game da abinci mai gina jiki, hanyar gudanarwa da kuma yawan maganin. Tare da ciwon sukari mai lalacewa, matsananciyar yunwa, shan barasa, ƙarancin aikin hanta, da kowane bayyanar cututtuka na hypoxia, ya kamata a dauki allunan tare da taka tsantsan saboda haɗarin da ake samu na lactic acidosis. Wannan yanayin sakamako ne na tarin metformin, sakamakon wanda aka gano lactate a cikin jini.

Yarda da kudade ya kunshi aikin tilas na gwaje-gwajen jini don halittar:

• Sau ɗaya a shekara yayin aikin koda na al'ada (a cikin marasa lafiya da ciwon sukari),
• fiye da sau 2 a shekara a cikin mutanen da ke dauke da HBV (haihuwar haihuwar hyperplasia) ko kuma a cikin tsofaffi marasa lafiya.

• yi amfani da tare da diuretics tare da taka tsantsan
• kar a sha magani kwana biyu kafin a yi gwajin X-ray ɗin da aka tsara ko tiyata ta amfani da maganin sa maye, maye gurbinsa da insulin ko wasu magunguna,
• sake dawo da magani ne kawai bayan awanni 48 daga lokacin da duk wani aikin tiyata kuma karkashin yanayin aikin kodan,
• Kada ku sha barasa tare da magani don ku guji yawan zubar jini ko faruwar wasu halaye saboda maye giya,
• miyagun ƙwayoyi suna rage ragi na halayen psychomotor, wanda zai iya yin illa ga tuki.

Ciwon sukari guda biyu shine ɗaya daga cikin cututtukan da mai haƙuri yake da shi. A gaban sauran cututtukan, yana da muhimmanci a sha maganin tare da taka tsantsan.

Specialungiyar musamman na marasa lafiya sune:

• masu juna biyu ko masu shayarwa (an sha maganin ne),
• marassa lafiya da ke fama da aikin hanta (an haramta amfani da maganin ne),
• mutane masu matsalar koda (tare da creatinine daga 135 mmol / l a cikin maza kuma sama da 100 mmol / l a cikin mata, an haramta maganin ƙwayar cuta).

Ba a bada shawarar yin amfani da maganin don amfani da marasa lafiya fiye da shekaru 60 ba, tun lokacin da suke yin aiki na jiki na jiki suna iya haɓaka lactic acidosis.

Side effects da yawan abin sama da ya kamata

Shan miyagun ƙwayoyi na iya haifar da halayen masu illa masu zuwa:

• dangane da tsarin narkewa - hare-hare na tashin zuciya da amai, asara ko cikakkiyar asara, rashin damuwa,
• daga cikin wurare dabam dabam na jini - leukopenia, harma da cutar malaria da pancytopenia,
• dangane da tsarin juyayi - ciwon kai,
• itching, urticaria, erythema,
• hypoglycemia ko lactic acidosis,
• zuciya palpitations.

Tare da yawan wuce haddi na miyagun ƙwayoyi, kyautatawa mara haƙuri yana ƙaruwa, cututtukan jini na haɓaka. A wannan yanayin, dole ne ku ci carbohydrates. Ci gaban hawan jini na iya haifar da asarar iko da kai. A wannan yanayin, mai haƙuri ba shi da damar ci, saboda haka za a buƙaci glucose na cikin jiki da kulawa da likita.

Yin hulɗa tare da wasu magunguna da analogues

An inganta tasirin hypoglycemic na miyagun ƙwayoyi a ƙarƙashin rinjayar wakilai kamar:

• Abubuwan Coumarin,
• Salicylates,
• MAO masu hanawa
• Abubuwan Phenylbutazone
• Sulfonamides,
• Miconazole
• Feniramidol
• Ethanol

Don rage tasirin amfani da miyagun ƙwayoyi ya shafa:

• Gagarinas,
• Thiazide masu maganin,
• hanawa (na baka),
• hormones don kula da glandar thyroid,
• Adrenaline.

Idan Glibomet saboda wasu dalilai bai dace ba, akwai da yawa na analogues ɗin, ana rarrabe cikin kayan haɗin kai da farashi.

Babban analogues:

Yana da mahimmanci a fahimci cewa likita kawai ya kamata ya yanke shawara game da maye gurbin Glibomet tare da wasu magunguna.

Bidiyo akan hanyoyi guda bakwai don rage sukarin jini a gida:

Ra'ayoyin masu haƙuri da farashin magunguna

Daga sake dubawar marasa lafiya, ana iya kammala da cewa ya kamata a sha miyagun ƙwayoyi tare da taka tsantsan, tunda yana da sakamako masu illa da yawa, lallai ne kuma a nemi ƙwararrun likita kafin a sha maganin.

Na fara shan maganin kamar yadda likita ya umurta. A ranar farko ta jiyya, ta ji alamun sau biyu na maganin rashin ƙarfi, kodayake abincin ta bai canza ba. Ban iya zuwa wurin likita nan da nan ba, don haka sai na yanke shawarar kaina in sake yin gwaji kuma na koma shan magungunan da suka gabata.

Na yi matukar farin ciki da Glibomet. Tare da taimakonsa, ya yiwu ya daidaita matakin sukari. Bayan karanta umarnin, da farko ya ji tsoron babban jerin sakamako masu illa, amma ya yanke shawarar amincewa da likita. Sakamakon ya gamsar.

A bara na ɗauki waɗannan kwayoyin. Wannan magani bai dace da ni ba, saboda ɗanɗanar ƙarfe a bakina yana kasancewa koyaushe kuma wani lokacin sai na ji ƙyamar.

Nikita Alexandrovich, shekara 65

Kayan aiki yana rage sukari da kyau, amma yayin cinikinsa ba za ku iya tsallake ko da abun ciye-ciye ba, ba kamar manyan abinci ba. Glybomet yana buƙatar abinci mai gina jiki na yau da kullun saboda babu hypoglycemia.

Kudin maganin yana kusan 350 rubles don allunan 40.

Glybomet - abun da ke ciki

Haɗuwa a cikin kowane kwamfutar hannu na abubuwa biyu masu aiki - metformin hydrochloride (400 MG) da glibenclamide (2.5 MG) ya sa ya yiwu ba kawai don sarrafa glycemia ba, har ma don rage yawan waɗannan abubuwan. Idan kowannensu an yi amfani da shi don maganin tauhidi, to maganin zai zama mafi girma.

Ya ƙunshi tsari da tsofaffi a cikin tsari na cellulose, sitaci masara, colloidal silicon dioxide, gelatin, glycerol, talc, magnesium stearate, acetylphthalyl cellulose, celethlose diethyl.

Abubuwan da ke tattare da magunguna

Ofaya daga cikin manyan abubuwan da ke aiki, glibenclamide, magani ne na sabon ƙarni na sulfonylurea aji, wanda aka haɗo shi cikin jerin mahimman kwayoyi tare da ƙwaƙwalwar ƙwayar cuta da kuma karin-pancreatic.

Bawai kawai yana ƙarfafa aikin koda ba a matsayin gabaɗaya, har ma yana haɓaka aikin samar da insulin ƙwayoyin cuta. Hanyar ayyukansu suna dogara ne da kariyar ƙwayoyin β-sel da ke lalata ta hanyar glucose mai ƙarfi, wanda ke ƙayyade ci gaban ciwon sukari, da ƙarfafa haɓakar insulin ƙwayoyin sel.

Shan Glibomet a layi daya tare da sarrafa glycemic yana inganta haɓakar lipid kuma yana rage haɗarin haɗarin jini. Ayyukan insulin yana ƙaruwa, kuma tare da shi ɗaukar glucose ta kyallen tsoka da hanta. Magungunan yana aiki a mataki na biyu na samar da insulin.

Metformin yana cikin biguanides - wani ɓangare na abubuwa masu karfafawa wanda ke rage ƙarancin ƙwayoyin makafi zuwa insulin nasu. Sake dawo da hankalin mutum ba shi da mahimmanci fiye da haɓakar ruɗar hormone, saboda tare da nau'in ciwon sukari na 2, ƙwaƙwalwar ƙwayar cuta ta haifar da ita har ma da wuce kima.

Metformin yana haɓaka lambar sadarwar masu karɓa da insulin, yana ƙaruwa da tasirin aikin hormone. Idan babu insulin a cikin jini, ba a bayyana tasirin warkewa ba.

Metformin yana da fasali na musamman:

An sake yin gwaje-gwaje na masu ciwon sikila 5800 masu ciwon sukari masu nau'in 2 a kasar Sin. Mahalarta cikin gwajin sun karbi metformin a hade tare da gyare-gyare na rayuwa. A cikin rukuni mai kulawa, masu sa kai kawai sun daidaita salon rayuwarsu. Tsawon watanni 63, a cikin rukunin farko, mutane 7.5 ke mutuwa a cikin mutane 1000 / shekara, a karo na biyu - na watanni 45, daidai da mutane 11.

Gabaɗaya, a cikin rukunin da ke karɓar metformin, yawan mace-mace ya kasance ƙasa da 29.5% fiye da yadda ake sarrafawa, kuma yawan lokutan abubuwan da suka shafi zuciya sun kasance 30-35%.

Magungunan yana fara aiki sa'o'i biyu bayan shigar esophagus, ingancinsa an tsara shi don awanni 12. Metformin baya haifar da barazanar hypoglycemic. Magungunan tare da babban tushe na shaida, ya wuce ingantaccen gwajin lokaci kuma yana buƙatar ciwon sukari a duk matakan daɗaɗɗar jiyya.

A yau, kasuwar magunguna tana ba da azuzuwan 10 na magungunan antidiabetic, amma metformin har yanzu shine mafi mashahuri magani don magance cututtukan type 2 na kowane irin cuta.

Haɗin synergistic na kayan aiki guda biyu na Glibomet yana da tasirin rikicewar jiki.

A mafi kyau duka rabo daga cikin rabo daga abubuwa aiki iya muhimmanci daidaita sashi na miyagun ƙwayoyi. Don ƙwayoyin-b, ƙwayoyin cuta suna da matukar muhimmanci: yana haɓaka amincin miyagun ƙwayoyi, yana rage haɗarin rashin aiki, da rage yiwuwar tasirin sakamako.

Abubuwan da ke cikin Pharmacokinetic

Glybenclamide daga ƙwayar gastrointestinal yana tunawa da rarraba shi sosai yadda yakamata - ta hanyar 84%, ana iya lura da tasirin miyagun ƙwayoyi bayan sa'o'i 1-2. Abubuwan da ke hade sunadaran sunadarai zuwa kashi 97 cikin dari.

Metabolism na Glibenclamide yana faruwa a cikin hanta, inda aka canza shi gaba daya zuwa metabolites marasa aiki. Rabin abin da aka kashe yana wucewa da kodan, sauran rabin kuma ta hanyar bututun bile. Rabin rayuwar yana awanni 10 kenan.

Ana amfani da Metformin gaba daya cikin tsarin narkewa, ana rarraba shi nan take ga gabobin da kyallen takarda, baya da alaƙa da furotin na jini kwata-kwata. A bioavailability na bangaren yana daga 50-60%.

A jikin, kusan bashi da ma'amala a jikinsa, a yadda take, ana nunawa yara ne da hanjinsa. Cire rabin rayuwar shine kusan awowi 10.

Gabaɗaya, mafi girman abubuwanda keɓaɓɓe a cikin jini yana faruwa awa ɗaya ko biyu bayan ɗaukar kwayar.

Alamu don magani tare da Glybomet

Umarnin na hukuma ya nuna cewa an wajabta maganin ne ga masu ciwon sukari na 2, wanda ya hada da masu ciwon suga da ke fama da cutar insulin, idan abinci na musamman, aikin motsa jiki da kuma magungunan maye gurbi ba su bayar da sakamakon da aka tsara ba.

Yawancin kwayoyi suna da tasiri na jaraba, idan jiki bai amsa maganin ta hanyar da ta dace ba, sun canza algorithm na magani ta hanyar rubuta Glibomet a cikin allunan.

Yadda ake ɗaukar Glibomet

Yin hukunci da sake dubawa game da endocrinologists, don kauce wa lactic acidosis, masu ciwon sukari da suka wuce shekaru 60, tare da aikin motsa jiki na yau da kullun, dole ne ku ɗauki miyagun ƙwayoyi tare da taka tsantsan, yin rikodin glucometer a kai a kai.

Akwai hani akan shan Glibomet:

An ƙaddara maganin ta hanyar endocrinologist gwargwadon shekarun mai haƙuri da sifofin asibiti, amma mai ƙirar ya ba da shawarar farawa tare da allunan guda biyu a kowace rana, koyaushe suna ɗaukar maganin. Matsakaicin maganin shine 2 g / day. Yana da kyau a rarraba liyafar a lokutan kullun. Idan wannan adadin ba shi da tasirin da ake tsammani, an wajabta jiyya tare da ƙari da ƙwayoyi masu ƙarfi.

Side effects da yawan abin sama da ya kamata

Akwai illoli da yawa waɗanda ba a iya so ba na iya faruwa bayan ɗaukar Glibomet, amma wannan bai kamata ya zama dalilin ƙin shan magani ba, saboda cutar da jiki baya rama ciwon suga ya fi ƙarfin haɗari na tasirin sakamako.

Don guje wa irin waɗannan yanayi, yana da mahimmanci don ƙididdige yawan ku. Idan ka'idar ta wuce gona da iri, masu ciwon sukari suna fidda yunwar da ba ta dace ba, asara ƙarfi, juyayi, rawar hannu.

Kwayar cutar yawan zafin jiki na iya zama tachycardia, bushewar fata, karuwar gumi, suma.

Daga cikin mummunan sakamako masu illa bayan shan Glibomed, hypoglycemia shine mafi haɗari a cikin wannan yanayin ga marasa lafiya da ke raunana da rashin lafiya mai tsawo, masu ciwon sukari na tsufa tare da ciwon sukari na dogon lokaci, giya, mutane suna aiki tuƙuru na jiki, da kuma duk wanda ke zaune rabin yunwar-abinci ( kasa da 1000 kcal / rana.) abinci.

Daga cikin alamun bayyanar cututtuka, mafi yawan su ne:

Idan rashin jin daɗi na ɗan lokaci ya faru bayan ɗaukar allunan, ana iya kawar dashi ta hanyar bayyanar cututtuka. Idan alamun bayyanar suna da ƙarfi ko alamun rashin lafiyan sun bayyana, to lallai za ku zaɓi analogues don Glibomet.

Sakamakon Cutar Magunguna

An lura da karuwa a cikin sakamako na hypoglycemic na Glybomet a yayin maganin layi daya tare da abubuwan da ke haifar da decumarol, phenylbutamazone, β-blockers, oxytetracycline, allopurinol, cimetidine, ethanol, sulfinpyrazone a cikin allurai masu mahimmanci, probenecid, chloramphenicol, babban magani, inon, .

Haɗin maganin tare da kwayoyin halittar glandon thyroid, maganin hana haihuwa, barbiturates, magungunan thiazide diuretic yana hana yiwuwar Glibomet.

Bi da bi, abubuwa masu aiki na Glibomet suna aiki ne a matsayin abubuwan kara kuzari ga magungunan kashe kwari.

Umarni na musamman

An daina amfani da Glibomet nan da nan lokacin da akwai alamun lactic acidosis: rauni mai ƙarfi, amai, spasm tsoka, jin zafi a cikin rami na ciki. Wanda aka cutar ya bukaci asibiti da gaggawa.

Koyarwar ta ba da shawarar yin jiyya tare da Glybomet don biye da saka idanu na ƙirar creatinine a cikin gwajin jini. Ga masu ciwon sukari tare da ƙoshin lafiya, irin wannan binciken ya wajaba aƙalla sau ɗaya a shekara, marasa lafiya waɗanda ƙirar creatinine suna kusa da ƙarshen ƙayyadaddun ƙa'idodi, kuma ya kamata a gwada marasa lafiya da suka manyanta sau 2 a shekara.

Kwana biyu kafin aikin tiyata da aka shirya, wanda yin amfani da maganin kashin hanji ko ta hanji, shan Glibomet an soke shi kuma mai ciwon sukari ya sauya zuwa insulin . Kuna iya dawo da hanyar magani tare da Glybomet bayan an ba da haƙuri na abinci mai gina jiki. Koda koda tare da ƙwayoyin koda na yau da kullun suna aiki, likitan ya yanke wannan shawarar ne kafin kwana biyu bayan aikin.

Shan kwayoyin suna buƙatar yin taka tsantsan yayin aiwatar da aiki mai haɗari ga rayuwa da lafiya, daidai lokacin da suke tuki motocin. Wannan yana da alaƙa da haɗarin hypoglycemia, raguwa a cikin adadin halayen psychomotor da ikon maida hankali.

Sakamakon magani tare da Glibomet zai dogara da yawa akan daidaiton bin shawarwarin da aka tsara a cikin umarnin da umarnin likitancin endocrinologist: bin abinci da tsari na bacci da hutawa, motsa jiki na yau da kullun, sarrafa glycemic system, ciki har da a gida.

Lokacin amfani da magani, ya zama dole a iyakance yawan shan giya gwargwadon iko (al'ada shine gilashin bushewar giya sau ɗaya a mako), tunda ethanol ya tsokani ci gaban glycemia, da kuma rikice-rikice-rikice-rikice-rikice-rikice a cikin yankin epigastric, rikicewar dyspeptik, fitilu masu zafi a saman jiki da kai, asara. daidaituwa, ciwon kai, bugun jini.

A cikin gazawar na koda, Glybomet an contraindicated lokacin da a cikin nazarin KK ya fi 135 mmol / l, idan mai haƙuri shine mutum, kuma sama da 110 mmol / l, idan mai ciwon sukari mace ce.

Kudin magunguna da dokokin adanawa

Shin Glybomet mai araha ne a sarkar kantin magani? Dangane da yankin, ana iya siyan magungunan don 200-350 rubles. Kowace kunshin na Glibomet, hoton wanda za'a iya gani a wannan sashin, yana dauke da allunan 40.
Don kada magani ya rasa tasiri, dole ne a kiyaye shi daga hasken rana kai tsaye da tsananin zafi.

Irin kwayoyi

Idan Glibomed ko da a cikin ƙwaƙwalwar ƙwayar cuta ba ya ba da sakamako da ake so, wata alerji ko wasu mummunan sakamako masu illa sun bayyana, an maye gurbin maganin tare da analogues tare da kayan aiki masu dacewa.

Don Glibomed, irin waɗannan magungunan na iya zama Allunan Diabeton, babban fili mai aiki wanda yake a cikin glyclazide, ko Dimaril, a cikin kwaren aiki mai aiki daidai yake da ɗayan abubuwan Glibomed, glimepiride.

Daga cikin sauran magungunan maganin antidiabetic tare da sakamako mai kama, Gluconorm, Bagomet Plus, Glucovans, Glibenclamide a hade tare da Metformin, an tsara Glyukofast.
Masanin ilimin kimiyar halittar yayi sauyawa, zai kuma yi lissafin sashi. Canji a cikin tsarin kulawa yana yiwuwa: ana ƙulla maganin analogues duka a cikin hadaddun jiyya da kuma nau'in monotherapy, ƙari ga abinci mai ƙanƙan da keɓaɓɓu da aikin jiki.

Ba shi yiwuwa 100% a hango ko hasashen halin jikin mutum ga sababbin magunguna, don haka farkon lokaci ya zama dole saurara ga dukkan alamu kuma ku gaya wa likita game da canji mai sauri a jiki, malaise, sakamakon gwajin glycemia tare da glucometer da wasu masu mahimmanci yayin lokacin karbuwa ga madadin hanyoyin abubuwan da suka faru.

Sunan Latin: Glibomet
Lambar ATX: A10B D02
Aiki mai aiki: Glibenclamide
da metformin hydrochloride
Mai masana'anta: Barcelona Chemie, Jamus
Hutun hutu daga kantin magani: Da takardar sayan magani
Yanayin ajiya: t har zuwa 25 C
Ranar cikawa: Shekaru 3

Glibomet yana nufin magungunan hypoglycemic, wanda aka wajabta don nau'in ciwon sukari na II na mellitus.

Ana nuna magani na Glibomet idan akwai nau'in ciwon sukari na 2 (ba a buƙatar insulin), lokacin da ilimin abinci tare da yin amfani da biguanides ko sulfonylurea ba su da tasiri.

Abun ciki da sakin siffofin

Abinda ke ciki na kwamfutar hannu Glibomet ya haɗa da abubuwa biyu masu aiki, waɗanda sune glibenclamide, kazalika da metformin hydrochloride, ƙaramar waɗannan abubuwa sune 2.5 mg da 400 MG, bi da bi. Presentarin ƙari yanzu:

• Glycerol dibehenate
• Povidone
• Colloidal silicon dioxide
• Magnesium stearate
• Croscarmellose sodium
• Macrogol.

Allunan suna zagaye, fari fari, akwai haɗari a gefe ɗaya. Allunan an sanya su a cikin bola mai ɗaukar farin ciki na guda 20., A ciki fakitin blister 2.

Hanyoyin warkarwa

Glibomet yana cikin adadin magungunan hypoglycemic tare da haɗakar abun da ke ciki, abubuwa masu aiki sune abubuwan asali na sulfonylurea, kazalika da biguanide na ƙarni na biyu. Magungunan yana kunna ayyukan insulin a cikin farji saboda rage ƙonewar ƙonewar ƙwayar sel ta hanyar glucose da kanta. Abun yana ƙara ƙarfin insulin, yayin ɗaure zuwa takamaiman ƙwayoyin da aka yi niyya yana ƙaruwa, kuma sakin insulin yana inganta. A lokacin maganin antidiabetic, ana daukar tsari na glucose da kwayoyin hanta da tsokoki yayin al'ada, yana hana lipolysis wanda ke faruwa a cikin kyallen adi adi. Ana nuna rikicewar glibenclamide a mataki na biyu na ɓoye insulin.

Metformin memba ne na ƙungiyar biguanide. Yana da tasiri mai motsawa a cikin yanayin jijiyoyin kyallen takarda zuwa insulin, yana rage jinkirin aiwatar da sinadarin glucose kai tsaye a cikin hanji, yana hana gluconeogenesis, sannan kuma yana da tasiri sosai kan yanayin aikin metabolism. A kan asalin wannan takamaiman sakamako, yana yiwuwa a hanzarta rage ƙarfin jiki a cikin mutanen da ke fama da ciwon sukari.

Ana yin rikodin sakamako na hypoglycemic na miyagun ƙwayoyi Glibomet 2 sa'o'i bayan lokacin ɗaukar allunan kuma an adana sa'o'i 12 na gaba. Saboda haɗuwa da abubuwa guda biyu masu aiki, ana yin aiki da abin da ake kira endogenous insulin, biguanide yana da tasiri kai tsaye ba kawai akan tsoka da tsopose nama ba, har ma a kan hanta hanta (saboda raguwar gluconeogenesis). A wannan yanayin, ba a yin rikodin ƙarfi na β-cell na pancreas, wanda ke rage yiwuwar cututtukan ƙwayoyin cuta da haɓaka bayyanar cututtuka masu yawa.

Matakan sha na glibenclamide ta mucosa na ciki shine kusan kashi 84%. Matsayi mafi girma na wannan abu a cikin jini an rubuta shi cikin awa 1-2 bayan amfani da kwayoyi. Sadarwa tare da sunadaran plasma - 97%. Canjin metabolism na wannan bangaren yana faruwa ne a cikin ƙwayoyin hanta; sakamakon haka, ana samar da adadin metabolites marasa aiki. A cikin aiwatar da cire samfuran metabolic, ƙwayar gastrointestinal da tsarin na koda yana da hannu. Kashe rabin rabin rayuwar ba ya wuce awoyi 5-10.

Rage metformin ta cikin mucosa na ciki sosai. Lokacin da ya shiga cikin keɓaɓɓiyar kewaya, ana lura da saurin rarraba cikin kyallen takarda, kusan bai shiga cikin dangantaka tare da sunadaran plasma ba. Wannan abun yana sashi cikin wani yanki, wanda tsarin koda da na hanji ke keɓe shi. Rabin rayuwar metformin shine 7 hours.

Glibomet: cikakken umarnin don amfani

Magungunan an yi niyya don gudanar da maganin baka. Gauki Glybomet tare da abinci. An zaɓi hanyar magani da tsarin kulawa daban-daban cikin la'akari da alamun alamun asibiti, matakin glucose a cikin jini, da kuma hoton gaba ɗaya na metabolism metabolism.

Sau da yawa, farashi na farko na maganin Glibomet shine allunan 1-3. Tuni a lokacin maganin antidiabetic, an zaɓi mafi inganci, wanda ke rage matakin glucose zuwa dabi'un al'ada. Yana da mahimmanci a lura cewa mafi girman magunguna na yau da kullun shine allunan 6.

Contraindications da Kariya

• Cessarfin mai saurin kamuwa da asali da ƙarin abubuwa
• Mellitus-insulin-da ke fama da cutar sankara (nau'in farko)
• Zauna a coma mai ciwon sukari ko precoma
• Mai tsananin rashin ƙarfi
• Ketoacidosis
• Take hakkin hanta da tsarin na koda
• Ciki, GV
• Lactic acidosis.

Kuna buƙatar dakatar da gwajin Glibomet nan da nan tare da alamun farko na lactic acidosis (bayyanar cututtukan da ke haifar da ciwo, jijiyoyin jiki, ƙoshin huhu) da kuma neman shawarar likitan ku.

A lokacin maganin antidiabetic, zai zama dole don saka idanu da creatine a cikin jini: in babu maganin cutar koda - 1 p. a ko'ina cikin shekara, tare da karuwar ƙirar mahaukata da tsofaffi marasa lafiya - 2-4 p. tsawon watanni 12

Za a buƙaci kammala magungunan a cikin sa'o'i 48 kafin aikin tiyatar da aka yi masa tare da maganin hana barci. Kuna iya ci gaba da hanya bayan cikakken maido da aikin abinci na yau da kullun, amma ba a baya ba sa'o'i 48 bayan aiki tare da tabbatar da cikakken aikin kodan.

A lokacin maganin antidiabetic, dole ne a kula sosai yayin aiki tare da madaidaitan hanyoyin aiki da tuki, tunda a yanayin hypoglycemia, saurin tsinkaye da halayen psychomotor na iya raguwa sosai.

Ingancin aikin jiyya zai dogara ne da yarda da shawarar likitan game da sashi, abinci mai gina jiki, aikin jiki da saka idanu na glucose.

Wajibi ne a cire amfani da giya, tunda akwai haɗarin hauhawar jini ko kuma bayyanar disulfiram-like.

Hulɗa da miyagun ƙwayoyi

Ana iya inganta tasirin hypoglycemic na kwayoyi tare da amfani da β-blockers na lokaci guda, abubuwan da suka dace da irin wannan abu kamar coumarin da phenylbutazone, MAO inhibitors, salicylates, miconazole, cimetidine, sulfanilamides da sulfonamides, oxytetracycline, probenecidhan, kimolfen kazalika da perhexiline.

COCs, kwayoyi dangane da hormones na thyroid, adrenaline, corticosteroids, diuretics na ƙungiyar thiazide tare da barbiturates suna rage tasirin hypoglycemic na Glibomet.

Tare da yin amfani da magungunan anticoagulants gabaɗaya, haɓaka tasirin su zai yiwu a lura.

Yayin ɗaukar cimetidine, haɓakawa da yiwuwar lactic acidosis mai yiwuwa ne.

Lokacin ɗaukar ckers-blockers, alamu masu sauƙi na hypoglycemia mai yiwuwa ne.

Lokacin amfani da wakilai masu amfani da radiopaque na iodine, akwai haɗarin haɗari na lalata tsarin tsarin aiki, kazalika da tara kayan abu na biyu na miyagun ƙwayoyi - metformin, wanda zai iya tsokani lactic acidosis.

Side effects da yawan abin sama da ya kamata

Wadanda suke shan wannan magani zasu iya fuskantar mawuyacin lamari:

• Gastrointestinal fili: tashin zuciya mai zafi tare da begen yin amai, asarar ci, tashin zuciya, zawo, wani dandano na ƙarfe a cikin kogon baki, da wuya - ƙaruwar aikin transaminases
• Tsarin hematopoietic: abin da ya faru na thrombocytopenia, leukopenia, da erythrocytopenia, da wuya - anemia (megaloblastic ko hemolytic type), pancytopenia, agranulocytotosis
• CNS: ciwon kai a kai a kai
• Fata: fata na urticaria, pruritus, erythema, alamun hoto
• Metabolism: abin da ya faru na hypokalemia, a wasu yanayi - lactic acidosis.

Idan ya cancanta, likita zai iya zaɓar analogues na miyagun ƙwayoyi Glybomet (alal misali, Diabeton). Abinda ya fi dacewa da Glibomet ko Diabeton, yana da kyau a bincika tare da likitan ku.

Wataƙila ci gaban lactic acidosis (tsokanar shi ta hanyar haɗuwa da metformin) da hypoglycemia (tare da glibenclamide).

Hanyar warkewa: tare da alamun lactic acidosis, zaku buƙaci kashe magungunan nan da nan kuma ku nemi taimakon likita. A wannan yanayin, ana daukar hemodialysis hanya mafi kyau don dakatar da alamun cutar.

Idan mai haƙuri ya kasance cikin yanayin rashin sani, to, allurar 40% dextrose tana shigar cikin jijiya (kimanin adadin shine har zuwa 80 ml), to dole ne a samar da maganin 10% na dextrose. Magani mai zuwa ya ƙunshi gudanar da glucagan (1 ml). Idan, bayan an yi amfani da magudin da aka yi, mai haƙuri bai san komai ba, ana maimaita ayyukan da aka bayyana. Idan babu tasirin warkewa, an wajabta kulawa mai zurfi sosai.

Servier Laboratories, Faransa

Farashi daga 269 zuwa 366 rubles.

Ciwon sukari - wani magani ne wanda ake nuna shi da tasirin sakamako mai ƙarfi. An wajabta shi don nau'in ciwon sukari na 2 na mellitus don daidaita tsarin insulin. Abubuwan da ke aiki na Diabeton shine gliclazide. Akwai shi a cikin kwamfutar hannu.

• Farashin Gaskiya
• Yana ba da gudummawa don asarar nauyi
• Yana rage hadarin rikicewar cutar sankara.

• Ba a umurce shi ba lokacin daukar ciki
• Yayin gudanarwa, damuwa na cikin damuwa zai yiwu
• Bai dace da kowa ba.

Sabuntawa ta karshe daga masana'anta 18.07.2005

Aikin magunguna

Glibenclamide - Yana motsa insulin insulin ta hanyar rage ƙonewar ƙwayar tsoka ta cikin ƙwayar jijiya, yana ƙara haɓaka insulin da ɗaurin ɗaukar nauyin ƙwayoyin, yana haɓaka sakin insulin, yana inganta tasirin insulin akan ƙwayar tsoka da haɓakar hanta, kuma yana hana lipolysis a cikin tsopose nama. Ayyukan Manzanni a mataki na biyu na insulin ɓoyewar insulin.
Metformin - yana hana gluconeogenesis a cikin hanta, yana rage shaƙar glucose daga hanji kuma yana ƙaruwa da amfani a cikin kyallen takarda, yana rage abun cikin triglycerides da cholesterol a cikin ƙwayar jini. Yana ɗaure ɗaurin insulin ga masu karɓa (in babu insulin a cikin jini, ba a bayyana tasirin warkewa ba). Ba ya haifar da maganganun hypoglycemic.

Pharmacokinetics

Glibenclamide yana cikin hanzari da adalci gaba ɗaya (84%) yana ɗaukar ƙwayar narkewa. Lokaci don isa ga max C - awa 7-8. Yin jingina ga kariyar plasma - 97%. An kusan kusan metabolized a cikin hanta don metabolites na aiki. Kashi 50% na cirewa daga kodan kuma 50% tare da bile. T 1/2 - 10-16 h.
Kodarin bayan shafewa cikin narkewa (narkewa - 48-52%) daga kodan ya keɓaɓɓe (galibi ba a canza shi ba), wani ɓangare na hanji. T 1/2 - 9-12 a.

Sashi da gudanarwa

A ciki yayin cin abinci. An saita sashi daban-daban, gwargwadon yanayin metabolism na sukari da sukari na jini. Yawancin lokaci kashi na farko shine allunan 1-3. kowace rana tare da zaɓin hankali na kashi har sai an sami sakamako na daskararrun cutar. Mafi kyawun tsari shine shan miyagun ƙwayoyi sau 2 a rana (safe da maraice). Ba'a ba da shawarar shan fiye da allunan 5 ba. Glibometa kowace rana.

Daidaita maganar kungiyoyin nosological

Wani lokaci ya zama dole, musamman idan aka zo ga masu ciwon sukari da ke buƙatar wasu kwayoyi don daidaita sukarin jini. Tabbas, a cikin kasuwar magunguna ta zamani akwai irin waɗannan magunguna. Amma galibi masana suna bada shawarar maganin "Glibomet." Nazarin masu ciwon sukari da likitoci sun nuna cewa da gaske wannan magani yana ba ku damar jimre da yanayin rikicin.

Bayanin abun da ke ciki. Tsarin Sakin Magunguna

Magungunan "Glibomet" yana samuwa a cikin nau'i na farin allunan zagaye tare da harsashi mai wuya. An sanya su cikin fitsarar roba na guda 20. A cikin kantin magani zaka iya siyan sikelin wanda ya ƙunshi blisters biyu.

Wannan haɗin kayan aiki ne, sabili da haka, abun da ke ciki ya ƙunshi abubuwa biyu masu aiki - glibenclamide (2.5 ml a cikin kwamfutar hannu ɗaya) da metformin a cikin nau'in hydrochloride. Tabbas, shirye-shiryen sun ƙunshi abubuwa masu taimako, musamman, sitaci masara, silicon dioxide, microcrystalline cellulose, talc, diethyl phthalate, glycerin, cellulose acetate phthalate, gelatin.

Yaya miyagun ƙwayoyi ke shafar jikin?

Tabbas, don farawa, yana da mahimmanci fahimtar kaddarorin magungunan. Tasirin hypoglycemic na shirye-shiryen Glibomet an ƙaddara shi ta hanyar abubuwan da ke cikin abubuwa biyu masu aiki gaba ɗaya.

Wannan kayan aikin yana aiki ne akan fitsari, watau waɗancan yankuna waɗanda ke da alhaki a cikin jiki. A lokaci guda, maganin yana inganta haɓakar ƙwaƙwalwar ƙwayoyin cuta zuwa wannan hormone. Saboda haka, Glibomet yana taimakawa rage jini na jini ba tare da yin amfani da insulin roba ba, wanda yake da matukar muhimmanci ga masu ciwon sukari na 2.

Har ila yau, maganin yana da kaddarorin rage kiba. A ƙarƙashin tasirinsa, matakin mai a cikin jini yana raguwa, wanda ke rage yuwuwar clots a cikin jini (ƙwanƙwasa jini). Metformin yana cikin rukunin biguanides. Wannan abu yana kunna ayyukan amfani da glucose ta tsokoki, yana hana gluconeogenesis a cikin hanta hanta, kuma yana hana adsorption na carbohydrates ta bangon hanji.

Glibenclamide yana ɗaukar hanzari ta ganuwar hanjinsa kuma ya kusan kasancewa gaba ɗaya (97%) yana ɗaukar garkuwar plasma. A cikin hanta, sai ya rushe, yana haifar da metabolites marasa aiki, wanda daga nan sai aka fitar daga jiki tare da jijiyoyi da fitsari. Rabin rayuwar shine 5 hours. Hakanan ana amfani da Metformin cikin hanzari a cikin jiki, amma baya daure wa garkuwar plasma. Wannan abun ba a jikin metabolized a jiki. daidai da sa'o'i biyu.

Yaushe ake amfani da maganin?

Mutane da yawa suna fama da wata cuta kamar ciwon sukari na 2. Abinci da magani a wannan yanayin suna da matukar muhimmanci. A matsayinka na mai mulki, ga marasa lafiya suna cin abincin da ya dace. Zaka iya daidaita sukarin jininka tare da sulfonylureas.

Magungunan "Glibomet" an wajabta shi idan maganin abinci da shan kudaden da ke sama ba su bayar da tasiri ba.

Yaya za a sha maganin "Glibomet"? Sashi ne m akayi daban-daban. A matsayinka na mai mulkin, kashi na farko shine allunan biyu. An kwashe su da abinci. Bugu da ari, adadin ƙwayar yana ƙaruwa don cimma sakamako mafi girma. Yawan yau da kullun kada ya wuce 2 g na metformin. Na gaba, ana rage rage kashi a hankali.

Magungunan "Glibomet": contraindications don magani

Wannan ingantaccen iko ne, magani mai mahimmanci, liyafar wacce zata yiwu kawai tare da izinin likita. A miyagun ƙwayoyi yana da wani kyakkyawan ban sha'awa jerin contraindications, wanda ya kamata ka sani da kanka tare da fara fara magani:

• hypersensitivity ga aiki da kuma kayan taimako na Allunan,
• rashin lafiyan sauran abubuwan da ake amfani da su na sulfonylurea, kazalika da sulfamide, probenecid ko di sulfates,
• wannan magani yana contraindicated a cikin mata yayin daukar ciki,
• rashin sakamako daga far,
• ciwon sukari na ciki da yanayin predomatous
• mummunan rauni na koda, gazawar koda,
• bushewa
• cututtuka
• cututtuka na kumburi wanda zai iya haifar da ci gaban hypoxia,
• ciwo mai zurfi na tsarin zuciya da jijiyoyin jini, gami da matsaloli tare da kewaya gefe, rashin isasshen ƙwayar cuta, ƙonewa mai guba da rawar jiki,
• cututtukan baya da suka gabata na tsarin numfashi,
• karancin infarction na asali ko lokacin gyarawa bayan shi,
• Lokaci guda na amfani da diuretics da magunguna don cutar hawan jini,
• acidosis ko hadarin ci gabansa,
• kasancewar a cikin tarihin mai haƙuri game da lokuta na lactic acidosis,
• mummunan cutar hanta
• rikicewar tsarin na numfashi,
• lokacin murmurewa bayan an cire wani bangare na cutar kansa,
• hanyoyin maganin dystrophic,
• na kullum barasa, a jihar m barasa maye,
• m zub da jini
• 'yan ta'adda
• lactation
• azumi ko bin tsaftataccen abinci.

Idan kuna da kowane ɗayan abubuwan da ke sama, to, yana da mahimmanci a ba da rahoto ga endocrinologist.

Wadanne illa za su haifar?

Shin koyaushe ana ɗaukarsa mai lafiya don ɗaukar allunan Glibomet? Sakamakon sakamako na gefen magani yana yiwuwa. Magungunan abubuwan da suka faru, duk da haka, ba a yin rikodin su sau da yawa, amma magani na iya shafan tsarin kwayoyin halitta daban-daban.

• Tsarin Lymphatic da jini . Hemolytic anemia, leukopenia, thrombocytopenia, pancytopenia, erythrocytopenia.
• CNS . Lokaci-lokaci yana faruwa da ciwon kai, tsinkaye mara kyau.
• Amfani da hango nesa. Rashin daidaituwa na masauki, rage ƙarancin gani na gani, wanda ke da alaƙa da canji a cikin sukarin jini.
• Tsarin rayuwa . Sharparin haɓakawa a cikin nauyin jiki, hypoglycemia, lactic acidosis. Yin magani na dogon lokaci wani lokacin yakan haifar da rauni ga ƙwayar bitamin B12 a cikin hanji, wanda daga baya yake ba da gudummawa ga ci gaban megaloblastic anemia.
• Tsarin narkewa . Ciwon hanci, amai, amai, zafi a cikin yankin, ciwan wuya, rashin cin abinci, bayyanar dandano mai ƙarfe a cikin bakin, jin daɗin ciki na ciki.
• Fata da ƙananan nama . Fata mai narkewa, erythema, nau'ikan nau'ikan exanthema, haɓaka yanayin ƙirar fata zuwa haske, rashin lafiyar dermatitis, urticaria.
• Allergic halayen . Rashes a kan fata, kumburi, jaundice, raguwa mai kaifi a cikin karfin jini, bacin rai, yanayin girgizawa.
• A hanta . Choraphis intrahepatic, maganin cutar hepatitis.
• Wasu rikice-rikice na iya bayyana, musamman, haɓaka yawan fitsari yau da kullun, asarar furotin da sodium ta jiki sakamakon lalacewar ƙura a cikin kodan.

Yana da kyau a lura cewa yawancin rikice-rikicen da ke sama ba sa buƙatar dakatar da maganin jiyya - ya isa don rage kashi kuma halayen da ba su dace ba su tafi da kansu. Dole ne a ƙara adadin ƙwayar yau da kullun a hankali kuma a hankali.

Bayanai kan ma'amala da wasu kwayoyi

Ba za a iya ɗaukar magani ba "Glibomet" (metformin) tare da barasa na ethyl, saboda wannan yana ƙaruwa da damar haɓakar lactic acidosis. A lokacin aikin tiyata, barasa da abubuwan sha da ke ɗauke da giya dole ne a jefar dasu.

An dakatar da amfani da wannan magani 48 hours kafin hanyoyin da ake amfani da waken bambancin aidin. Amfani da wadannan magunguna a lokaci daya zai iya haifar da ci gaban kiba koda.

Idan kun dauki "Glybomet" tare da insulin, steroids anabolic, beta-adrenergic blockers, magungunan tetracycline, to, haɗarin haɓakar haɓakar jini yana ƙaruwa. Masu ciwon sukari koyaushe suna buƙatar sanar da likita game da duk magungunan da suke sha.

Cost da analogues

A cikin maganin zamani, ana amfani da maganin "Glibomet" sau da yawa. Reviews na masu ciwon sukari, alamu da contraindications ne, ba shakka, mahimman maki. Amma ba ƙaramin mahimmanci ba ne farashinsa. Tabbas, yana da wuya a faɗi ainihin lambar, amma a matsakaici farashin kunshin 40 Allunan ya tashi daga 340 zuwa 380 rubles, wanda a zahiri ba shi da yawa.

Tabbas, wannan maganin ba koyaushe dace da marasa lafiya. Akwai isassun musanya a kasuwar hada magunguna ta zamani. Misali, tare da ciwon sukari na nau'in na biyu, irin su Avandamet, Vokanamet, Glukovans galibi ana amfani dasu. Ba ƙasa da sau da yawa, ana tsara marasa lafiya Dibizid, Dianorm ko Sinjarji. Tabbas, kawai halartar endocrinologist na iya zaɓar ingantaccen analog.

Magungunan "Glibomet": sake dubawa game da masu ciwon sukari da likitoci

Ana amfani da wannan magani sosai a maganin zamani. Amma menene magani da Glibomet yayi kama da gaske? Nazarin masu ciwon sukari, har ma da masana, sun tabbatar da cewa miyagun ƙwayoyi suna magance lafiya sakamakon sakamakon rashin lafiyar insulin-da ke fama da rashin lafiyar insulin.

Dangane da bincike, ƙwayar tana kunna ɓangaren ƙwayar cuta wanda ke da alhakin haɗarin insulin. Wannan shine ainihin abin da ake buƙata don cuta irin su ciwon sukari na 2. Abinci da magani a wannan yanayin suna da matukar muhimmanci.

Ba a daɗe da rikodin maganganun halayen da ba su dace ba a cikin aikin likita. An yarda da maganin sosai, kuma farashinsa na da ma'ana.

Cungiyar asibiti da magunguna: & nbsp

Kunshe cikin kwayoyi

A.10.B.D.02 Metformin da sulfonamides

Hada wakili na antiglycemic.

Abubuwan da ke haifar da ƙwayar sulfonylurea na ƙarni na biyu, ta hanyar rage bakin ƙofa don ƙarfafa ƙwayoyin panc-sel tare da glucose, yana ƙarfafa ƙwayar insulin, yana ƙaruwa da sakinsa da kuma darajar ɗaura nauyi zuwa sel. Tasirin hypoglycemic ya dogara da yawan β-sel masu aiki.

Ressesarfafa tara platelet, yana da fibrinolytic, hypoliplera da rauni diuretic effects.

Yana rage shayewar glucose daga hanji kuma yana inganta amfani dashi, yana kara ji da jijiyoyi zuwa insulin, kuma yana hana gluconeogenesis a hanta. Yana rage matakin lipoproteins mai yawa da triglycerides a cikin jini na jini. Ba ya haifar da maganganun hypoglycemic, ba ya shafar ɓoye insulin ta hanyar β-sel na fitsari. Ta hanyar hana mai hana mai kunnawa aiki, plasminogen nama yana da tasirin fibrinolytic. Yanke ko rage karfin jiki.

Bayan gudanar da baki, yana narkewa a cikin jijiyar ciki da kashi 90%. Matsakaicin maida hankali a cikin jini yana isa bayan awa 2. Sadarwar tare da sunadaran plasma kashi 95%.

Matsakaicin warkewar magani yana haɓaka sa'o'i 7-8 bayan gudanarwa. Tsawon lokacin aikin shine awoyi 12. Metabolism a cikin hanta.

Cire rabin rayuwa yana sanya awa 2-10. Cire kodan da feces.

Bayan gudanar da baki, har zuwa kashi 50-60% yana cikin jijiyoyin. Matsakaicin maida hankali a cikin jini yana isa bayan awa 2.5. Bai da alaƙa ga furotin plasma.

Yana tarawa a cikin ƙwayar tsoka, gyada mai, hanta da hanta.

Rabin rayuwar shine awa 6. Cutar da kukan su ba canzawa.

Ana amfani dashi don kula da cututtukan cututtukan cututtukan da ba na insulin-insulin ba.

IV.E10-E14.E11 Ciwon sukari wanda ba shi da insulin-insulin

Nau'in m ciwon sukari mellitus (insulin-dogara), coma, ketoacidosis, rashin haƙuri na mutum.

Gargaɗi: Cututtukan da ke tattare da tsarin endocrine suna shafar metabolism: adenohypophysial da adrenocortical insufficiency, thyroid dysfunction. Ciki da kuma lactation: Sashi da gudanarwa:

Amfani da maganin haɗin gwiwa na baya tare da metformin da glibenclamide: kashi na farko kada ya wuce kashi na yau da kullun na glibenclamide (ko kuma daidai gwargwado na wani sulfonylurea) da metformin da aka ɗauka a baya. Kowane makonni 2 ko fiye bayan fara magani, ana daidaita sashi gwargwadon matakin glycemia.

A ciki, yayin abinci, a farkon kashi na 2.5 na glibenclamide da 500 MG na metformin (1 kwamfutar hannu 1) sau 2 a rana. Zai yiwu karuwa ko raguwa a kashi (dangane da matakin glucose a cikin jini).

Mafi girma na yau da kullun (2.5 ko 5 MG na glibenclamide da 500 MG na metformin): 4 Allunan.

Matsakaicin mafi girma guda (2.5 mg glibenclamide da 500 mg metformin): 1 kwamfutar hannu.

Tsarin ciwan kai : da wuya - thrombocytopenia, erythrocytopenia, granulocytopenia, hemolytic anemia.

Tsarin narkewa : dyspepsia, tashin zuciya, amai, gudawa, gudawa, zazzabin cizon sauro, cholestatic jaundice.

Tsarin Musculoskeletal : arthralgia.

Magungunan ƙwayar cuta kurji.

Tsarin Urinary : proteinuria.

Tsarin tsakiya da na gefe mai juyayi : rashin bacci, paresthesia, rashin bacci.

Tsarin zuciya : tachycardia.

Tsarin narkewa : asarar ci, maƙarƙashiya, wani lokacin - zafin cutar basur.

Tsarin Musculoskeletal: Bayyanar cututtuka na lactic acidosis sune spasms na tsokoki maraƙi.

Jiyya: sukari a ciki, tare da asarar hankali - gudanar da aikin kwantar da hankali na maganin 40% dextrose.

Masu hana ƙwayoyin ƙwayar plasma na miyagun ƙwayoyi suna haɓaka isoenzyme 3A4 cytochrome P450 inhibitors :,.

Matsakaicin glycemia yana raguwa yayin amfani da miyagun ƙwayoyi tare da thiazide diuretics, jigilar tashar alli mai sauƙi, shirye-shiryen lithium, glucocorticoids, isoniazid, sympathomimetics, nicotinic acid, phenytoin, phenothiazines, hormones thyroid.

Tare da amfani da lokaci guda tare da furosemide, ragewa kashi ya zama dole.

Shan giya (musamman akan komai a ciki) yayin jiyya yana haifar da disulfiram-kamar halayen, yana ƙara haɗuwa da lactic acid a cikin jini na jini da haɗarin hypoglycemia.

Yayin cikin ciki da lactation, har ma a cikin yanayi bayan raunin da yayi yawa, ana soke maganin, kuma ana ci gaba da kula da ciwon sukari da allurar insulin.