Hinapril na miyagun ƙwayoyi: umarnin don amfani

Magungunan rigakafi, ACE inhibitor.

Quinapril hydrochloride gishiri ne na quinapril, ethyl ester na ACE inhibitor quinaprilat, wanda ba ya da ƙungiyar sulfhydryl.

Quinapril da sauri ya lalata tare da ƙirƙirar quinaprilat (quinapril diacid shine babban metabolite), wanda shine mai hana ACE mai ƙarfi. ACE peptidyldipeptidase ne wanda ke haifar da juyowar juyawar angiotensin I zuwa angiotensin II, wanda ke da tasirin vasoconstrictor kuma yana da hannu a cikin sarrafa sautin jijiyoyin bugun gini da aiki ta hanyoyin daban-daban, gami da haɓakar samar da aldosterone ta hanyar adrenal cortex. Quinapril yana hana ayyukan zagayawa da jijiyoyin ACE kuma hakan yana rage ayyukan vasopressor da samar da aldosterone. Ragewa daga matakin angiotensin II ta hanyar bayanan martani yana haifar da karuwa cikin renin ɓoyewa da ayyukanta a cikin jini na jini.

Babban aikin antihypertensive sakamako na quinapril ana ɗauka a matsayin rage yawan ayyukan RAAS, duk da haka, ƙwayar tana nuna tasiri har ma a cikin marasa lafiya da ƙananan ƙwayar jijiya. ACE daidai yake a cikin sifar don kininase II, enzyme wanda ke rushe bradykinin, peptide mai iko da kayan maye. Har yanzu ba a sani ba ko karuwa a cikin matakan bradykinin yana da mahimmanci ga warkewar cutar quinapril. Tsawon lokacin sakamako na rigakafi na quinapril ya kasance mafi girma fiye da tsawon lokacin da yake haifar da tasiri a cikin kewaya ACE. An bayyana kusancin dake tsakanin hanawar nama ACE da tsawon lokacin tasirin maganin.

ACE inhibitors, ciki har da quinapril, na iya haɓaka hankalin insulin.

Yin amfani da quinapril a kashi 10-40 MG a cikin marasa lafiya da rauni zuwa matsakaici mai ƙarfi na hauhawar jini yana haifar da raguwar hauhawar jini duka biyu a cikin zaune da matsayi kuma yana da sakamako kaɗan a cikin bugun zuciya. Tasirin antihypertensive yana bayyana kanta a cikin awa 1 kuma yawanci ya kai mafi yawa a cikin sa'o'i 2-4 bayan shan magani. A cikin wasu marasa lafiya, ana lura da tasirin antihypertensive matsakaici makonni biyu bayan fara magani.

Sakamakon antihypertensive na miyagun ƙwayoyi lokacin da aka yi amfani dashi a cikin allurai masu bada shawara a cikin mafi yawan marasa lafiya yana ɗaukar sa'o'i 24 kuma suna ci gaba yayin jiyya na dogon lokaci.

Nazarin hemodynamic a cikin marasa lafiya tare da hauhawar jini ya nuna cewa raguwa a cikin karfin jini a ƙarƙashin rinjayar hinapril yana haɗuwa tare da raguwa a cikin OPSS da juriya na jijiyoyin bugun jini, yayin da ƙuƙwalwar zuciya, ƙirar bugun jini, ƙaddamarwar jini, ƙirar ƙirar ƙasa da ƙirar filtration dan kadan ko ba a canza ba.

Sakamakon warkewa na miyagun ƙwayoyi a cikin allurai na yau da kullun yana da daidaituwa a cikin tsofaffi (sama da 65) da kuma a cikin marasa lafiya na ƙarami, a cikin tsofaffi yawan adadin abubuwan da ke faruwa ba sa ƙaruwa.

Yin amfani da hinapril a cikin marasa lafiya da rauni na zuciya yana haifar da raguwa a cikin OPSS, ma'anar karfin jini, systolic da dastolic pressure, matsin lamba na huhun hanji da haɓaka fitowar zuciya.

A cikin marasa lafiya 149 waɗanda suka shiga jijiyar jijiyoyin zuciya marasa aikin jiyya, yin jiyya tare da quinapril a kashi 40 MG kowace rana idan aka kwatanta da placebo ya haifar da raguwar rikice-rikice na cututtukan ƙwayar cuta a cikin shekara guda bayan tiyata.

A cikin marasa lafiya tare da tabbatar da cututtukan atherosclerosis wanda basu da hauhawar jini ko rashin karfin zuciya, quinapril yana inganta aiki mai wahala a cikin jijiyoyin zuciya da jijiyoyin jini.

Tasirin quinapril akan aikin endothelial yana da alaƙa da haɓaka aikin nitric oxide. Ana tunanin ƙoshin Endothelial wani tsari ne mai mahimmanci don haɓakar atherosclerosis na jijiya. Ba a kafa mahimmancin asibiti na inganta aikin aikin endothelial ba.

Pharmacokinetics

Baƙon abu, rarrabawa, metabolism

Bayan shigar Cmax na quinapril a cikin plasma, ana samunsa cikin awa 1. Matsakaicin shan magungunan ya kusan kashi 60%. Cin abinci baya shafar matakin ɗaukar ciki, amma yawanci da ƙimar sha da quinapril ana ɗan rage yayin shan abinci mai mai.

Quinapril yana metabolized zuwa quinaprilat (kusan 38% na maganin) kuma karamin adadin sauran metabolites marasa aiki. T1 / 2 na quinapril daga plasma shine kimanin awa 1. Cikas na quinaprilat a cikin plasma ya kai kimanin sa'o'i 2 bayan shigowar quinapril. Aƙalla kwatankwacin kashi 97% na quinapril ko quinaprilat suna kewaya cikin plasma a cikin yanayin ƙaddarawar furotin. Hinapril da metabolites din ba su shiga BBB ba.

Quinapril da quinaprilat an ware su a cikin fitsari (61%), haka kuma a feces (37%), T1 / 2 kusan 3 hours ne.

Sakawa lokacin

Lokacin gudanar da maganin monotherapy don hauhawar jini, shawarar da aka fara farawa ta Accupro® a cikin marasa lafiyar da ba a karbar diuretics shine 10 mg ko 20 mg sau ɗaya a rana. Dangane da tasirin asibiti, ana iya ƙara kashi (ninki biyu) zuwa gwargwadon goyon baya na 20 MG ko 40 MG kowace rana, wanda galibi ana wajabta shi a cikin kashi 1 ko kuma ya kasu kashi 2. A matsayinka na mai mulkin, ya kamata a canza sashi a tsaka-tsakin makonni 4. A cikin yawancin marasa lafiya, ana iya samun ingantaccen iko da karfin hawan jini yayin jinya na tsawan lokaci ta amfani da miyagun ƙwayoyi 1 lokaci kowace rana. Matsakaicin adadin yau da kullun shine 80 MG.

A cikin marasa lafiya waɗanda ke ci gaba da shan diuretics, shawarar farko na Accupro® shine 5 MG, a nan gaba ana ƙaruwa (kamar yadda aka nuna a sama) har sai an sami sakamako mafi kyau.

A cikin rauni na zuciya, rashin amfani da maganin ana nuna shi azaman kari don warkarwa tare da diuretics da / ko cardiac glycosides. Shawarar farko da aka ba da shawarar a cikin marasa lafiya tare da raunin zuciya shine 5 MG 1 ko sau 2 a rana, bayan shan maganin, ya kamata a lura da mai haƙuri don gano alamun cututtukan zuciya. Idan haƙuri a cikin kashi na farko na Accupro® yana da kyau, to ana iya haɓaka shi zuwa ƙwayar tasiri, wanda yawanci shine 10-40 MG kowace rana a cikin adadin biyu daidai tare da maganin kwantar da hankali.

Game da aiki na nakasassu na aiki, shawarar da aka bayar ta farko ta Accupro® shine 5 MG a cikin marasa lafiya tare da CC fiye da 30 ml / min da 2.5 MG a cikin marasa lafiya tare da CC kasa da 30 ml / min. Idan haƙuri a cikin kashi na farko yana da kyau, to gobe za a iya tsara Accupro® 2 In babu matsanancin ƙwaƙwalwar ƙwayar jijiya ko kuma wani mummunan rauni a aikin renal, ana iya karuwa kashi a makarancin mako, yin la’akari da tasirin asibiti da illolin motsa jiki.

Ganin ba da bayanan asibiti da na kantin magani a cikin marasa lafiya da ke fama da rauni na aikin ƙirar, ana bayar da shawarar farko don zaɓar kamar haka.

Hanyar aikace-aikace

Dangane da tasirin asibiti, ana iya ƙara kashi (ninki biyu) zuwa gwargwadon goyon baya na 20 ko 40 mg / rana, wanda akasari ana yin shi ne a cikin allurai 1 ko 2. A matsayinka na mai mulkin, ya kamata a canza sashi a tsaka-tsakin makonni 4. A cikin mafi yawan marasa lafiya, yin amfani da miyagun ƙwayoyi Hinapril-SZ 1 lokaci ɗaya kowace rana yana ba da damar samun ingantaccen amsawar warkewa. Matsakaicin adadin yau da kullun shine 80 MG / rana.
Amfani guda daya tare da diuretics: shawarar da aka fara bayarwa na Hinapril-SZ a cikin marasa lafiyar da ke ci gaba da shan diuretics shine 5 MG sau ɗaya a rana, kuma daga baya an kara shi (kamar yadda aka bayyana a sama) har sai an sami sakamako mai kyau na warkewa.
CHF
Shafin farko da aka bayar da shawarar Hinapril-SZ shine 5 MG 1 ko sau 2 a rana.
Bayan ya sha maganin, mai haƙuri ya kamata ya kasance a ƙarƙashin kulawar likita don gano alamun hypotension artpotomatik. Idan kashi na farko na Hinapril-SZ an yarda da shi sosai, ana iya ƙaruwa zuwa 1040 mg / rana ta rarrabuwa zuwa allurai 2.
Paarancin aiki na haya
Ganin ba da bayanai na asibiti da kuma kantin magani a cikin marasa lafiya da ke fama da rauni na aikin haya, ana bayar da shawarar farko don zaɓar kamar haka:
Lokacin da Cl creatinine ya fi 60 ml / min, shawarar farko da aka bayar shine 10 MG, 30-60 ml / min - 5 mg, 10-30 ml / min - 2.5 mg (1/2 tab. 5 mg).
Idan haƙuri ga kashi na farko yana da kyau, to ana iya amfani da miyagun ƙwayoyi Hinapril-SZ sau 2 a rana. Za'a iya ƙara yawan kashi na Hinapril-SZ a hankali, ba fiye da sau ɗaya a mako ba, la'akari da asibiti, tasirin hemodynamic, kazalika da aikin renal.
Tsofaffi marasa lafiya
Shawarar farko da aka bayar da shawarar Hinapril-SZ a cikin tsofaffi marasa lafiya shine 10 MG sau ɗaya a rana, a nan gaba ana ƙaruwa har sai an sami sakamako mai kyau na warkewa.

Side effects

Abubuwa masu haɗari tare da quinapril yawanci mai laushi ne da jinkiri. Mafi yawanci, ciwon kai (7.2%), farin ciki (5.5%), tari (3.9%), gajiya (3.5%), rhinitis (3.2%), tashin zuciya da / ko amai (2.8%) da myalgia (2.2%). Ya kamata a lura cewa a cikin yanayin hali, tari ba shi da amfani, yana da ƙarfi, kuma ya ɓace bayan dakatar da magani.
Mahimmancin cirewar quinapril sakamakon sakamako masu illa an lura da shi a cikin kashi 5.3% na lokuta.
Mai zuwa jerin lambobin raunin da aka rarraba ta tsarin tsarin kwayoyin halitta da kuma yawan aukuwar lamarin (rarrabuwa na WHO): sau da yawa fiye da 1/10, sau da yawa daga fiye da 1/100 zuwa ƙasa da 1/10, sau da yawa daga sama da 1/1000 zuwa ƙasa da 1 / 100, da wuya - daga 1/10000 zuwa ƙasa da 1/1000, da wuya - daga ƙasa da 1/10000, gami da saƙonni na mutum.
Daga gefen tsarin juyayi: sau da yawa - ciwon kai, rashin jin daɗi, rashin bacci, paresthesia, ƙarancin jiki, rashin ƙarfi - rashin ƙarfi, haɓaka tashin hankali, tashin zuciya, vertigo.
Daga narkarda abinci: sau da yawa - tashin zuciya da / ko amai, gudawa, dyspepsia, ciwon ciki, mara sa-kai - bushewar mucous na bakin ko makogwaro, ƙwanƙwasa, huhun hanji *, angioedema na hanji, amai da gudawa, da wuya - hepatitis.
Janar cuta da rikice-rikice a wurin yin allura: ba sau da yawa - edema (na waje ko na gaba ɗaya), malaise, cututtukan hoto ko bidiyo mai zagaya yanar gizo da sauri.
Daga tsarin jijiyoyin jini da jijiyoyin jiki: akai-akai - hawan jini mai cuta, * thrombocytopenia *.
A wani ɓangare na CVS: sau da yawa - raguwa alama a cikin karfin jini, a lokaci-lokaci - angina pectoris, palpitations, tachycardia, gazawar zuciya, bugun zuciya na zuciya, bugun jini, hauhawar jini, tashin zuciya, bugun zuciya, tashin hankali *, kasala *, alamun vasodilation.
Daga tsarin numfashi, kirji da gabobin jiki: sau da yawa - tari, dyspnea, pharyngitis, ciwon kirji.
A ɓangaren fata da ƙananan kasusuwa na ƙasa: na lokaci-lokaci - alopecia *, exfoliative dermatitis *, ƙara yawan ɗumi, pemphigus *, halayen hoto *, itching, kurji.
Daga gefen musculoskeletal da nama mai haɗuwa: sau da yawa - ciwon baya, mara wuya sau biyu - arthralgia.
Daga kodan da urinary fili: akai-akai - urinary fili cututtuka, m renal gazawar.
Daga al'aura da mammary gland shine yake: akai-akai - rage rauni.
Daga gefen bangaren hangen nesa: akai-akai - mara hangen nesa.
Daga gefen tsarin rigakafi: na lokaci-lokaci - halayen anaphylactic *, da wuya - angioedema.
Sauran: da wuya - cututtukan eosinophilic.
Manuniya na dakin gwaje-gwaje: da wuya dai - agranulocytosis da neutropenia, kodayake har yanzu ba a kafa dangantakar causal tare da amfani da hinapril ba.
Hyperkalemia: duba "Umarnin na musamman."
Createinine da jini urea na jini: karuwa (fiye da sau 1.25 idan aka kwatanta da VGN) na kwayar halittar creatinine da jini urea nitrogen an lura dashi a cikin 2 da 2% na marasa lafiya da ke karɓar maganin moninaherilina guda biyu, bi da bi. Yiwuwar karuwa a cikin waɗannan sigogi a cikin marasa lafiya a lokaci guda suna karbar diuretics ya fi yadda ake amfani da quinapril kadai. Tare da ƙarin magani, masu nuna alama sukan dawo al'ada.
* - Lessarancin abubuwan da ke faruwa ko rikice-rikice a cikin binciken bayan-tallace-tallace.
Tare da yin amfani da inhibitors na ACE na lokaci daya da shirye-shiryen zinare (sodium acurothiomalate, iv), an bayyana hadadden alamomin, ciki har da fitsarin fuska, tashin zuciya, amai, da raguwar hauhawar jini.

Da abun da ke ciki da kuma irin maganin

Babban aiki na miyagun ƙwayoyi Hinapril shine quinapril hydrochloride.

Hakanan a cikin tsarinta akwai wasu abubuwan taimako:

• madara sukari (lactose monohydrate),
• ainihin ma'adinin magnesium carbonate,
• primellose (sodium croscarmellose),
• povidone
• magnesium stearate,
• aerosil (sillofon silicon dioxide).

Hanyar sakin magungunan Hinapril shine Allunan zagaye, an rufe shi tare da shafi fim mai launin rawaya. Suna biconvex kuma suna cikin haɗari. A sashen giciye, zuciyar tana da fararen fari, ko kuma fararen launi.

An gabatar da wannan magani a cikin fakiti mai bakin ciki wanda ya ƙunshi allunan 10 ko 30. Hakanan ana samunsa a cikin kwalba da kwalabe waɗanda aka yi da kayan kayan polymer.

Alamu don amfani

An tsara allunan Hinapril don magance cututtuka irin su:

Za'a iya amfani da wannan maganin duka a cikin maganin motsa jiki na mono, kuma a hade tare da beta-blockers da thiazide diuretics.

Yin hulɗa tare da sauran nau'ikan magunguna

Yayin shan magungunan Hinapril tare da shirye-shiryen lithium, marasa lafiya na iya ƙara yawan abubuwan da ke cikin lithium a cikin jijiyoyin jini. Hadarin da ke tattare da maye na lithium yana ƙaruwa ne idan akwai haɗin gwiwa tare da ma'aikatan diuretic.

Haɗewar yin amfani da quinapril tare da magungunan hypoglycemic yana haifar da karuwa a cikin aikin su.

Amfani da waɗannan allunan tare da shirye-shirye waɗanda ke ɗauke da ethanol ba abin yarda ba ne. Sakamakon mummunan haɗin wannan haɗin shine babban karuwa a cikin tasirin antihypertensive.

Yawan abin sama da ya kamata

Idan mai haƙuri ba da gangan sama da abin da aka iya yarda da allurar Hinapril, wannan na iya haifar da raguwa da kaɗaici a cikin karfin jini, rauni na gani, rauni gaba ɗaya da kuma jikewa.

A cikin irin waɗannan yanayi, ya zama dole don aiwatar da maganin tiyata kai tsaye kuma na ɗan lokaci ƙin shan maganin.

Kuna iya sake komawa alƙawari kawai bayan tuntuɓar likita.

Contraindications

Allunan Hinapril suna contraindicated a:

• rashin haƙuri da aka gyara daga cikin miyagun ƙwayoyi,
• mai aiki mai ɗaukar hoto,
• hyperkalemia
• tarihin rashin lafiyar angioedema,
• angioedema, wacce ke gado ko yanayin rashin haihuwa,
• ciwon sukari
• ciki da lactation.

Bugu da kari, ba a ba da maganin wannan maganin don kula da marasa lafiya da ke ƙasa da shekara 18.

Sharuɗɗan da yanayin ajiya

Rayuwar shiryayye daga allunan Hinapril shekaru uku ne daga ranar da aka ƙera su. An bada shawara don adana su a yanayin zafi har zuwa +25 digiri, a cikin wurin da ba a iya kaiwa ga yara, amintaccen kariya daga haske da danshi kai tsaye.

A cikin magunguna na Rasha don sayan maganin Hinapril, dole ne a gabatar da takardar sayan magani. Matsakaicin farashin waɗannan allunan sun yi ƙasa kaɗan kuma yawansu yakai 80-160 rubles a kowace kunshin.

A cikin Ukraine Farashin Hinapril shima yayi ƙasa - kusan 40-75 hryvnia.

A cikin masana'antar sarrafa magunguna ta zamani, ana gabatar da samfuran magunguna masu yawa na allunan hinapril. Mafi mashahuri da aka nema daga gare su sun haɗa da:

Ba'a bada shawara don zaɓar wani analog na Hinapril da kansa ba. Don waɗannan dalilai, ya kamata ku nemi ƙwararren likita wanda zai ba da mafi kyawun zaɓi dangane da alamun asibiti da kuma halayen mutum na gaba ɗaya na mai haƙuri.

Hinapril na miyagun ƙwayoyi yana karɓar sake dubawa saboda ingantaccen tasiri, farashin mai araha da sauƙi mai sauƙi ga yawancin marasa lafiya.

Mutanen da suka yi amfani da wadannan kwayoyin don maganin cutar prophylactic da warkewa, lura cewa hinapril a sauƙaƙe kuma yana rage karfin jini, haka kuma yana rage mahimmancin yanayin rashin lafiyar zuciya. Effectsarancin sakamako masu illa ana haɗa su da rashin bin ka'idodi don shan ƙwayoyi.

Kuna iya karanta ƙarin bayani game da tsokaci da sake dubawa a ƙarshen wannan labarin.

Idan kun saba da maganin Hinapril, ku ɗauki ɗan lokaci kaɗan ku bar abin da kuka bita game da shi. Wannan zai taimaka wa sauran masu amfani yayin zabar magani.

Kammalawa

Idan kuna shirin shan maganin Hinapril don maganin warkewa ko dalilai na prophylactic, tabbatar da la'akari da mahimman kayan aikin.

1. Hinapril yana samuwa a cikin nau'i na Allunan don amfani da baka.
2. Dangane da ganewar asali da yanayin haƙuri, kashi na farko na wannan magani shine 5 ko 10 MG. A tsawon lokaci, a karkashin kulawar likita, ana iya ƙaruwa ta rarrabuwa cikin hanyoyi biyu.
3. Matsakaicin yawan maganin yau da kullun shine 80 MG.
4. Ba a yarda a sha wannan maganin ga mata yayin daukar ciki da lactation.
5. Game da yawan shaye shaye na miyagun ƙwayoyi, raguwa mai yawa a cikin karfin jini da abin da ya faru na rauni na gaba ɗaya mai yiwuwa ne. Don kawar da wannan yanayin, ana buƙatar maganin tilas.
6. Ba a wajabta Hinapril ba ga matasa marasa lafiya waɗanda shekarunsu ba su wuce 18 ba.
7. Gabaɗaya amfani da allunan Hinaprir tare da kwayoyi dauke da lithium da ethanol ba abu ne da za a karɓa ba.

Sashi na miyagun ƙwayoyi

Kamar yadda aka ambata a baya, dole ne a sha maganin. Ganye kwamfutar hannu ba a cika so ba. Sha shi da ruwa mai yawa. Sashi na maganin yana dogara da cutar da mai haƙuri yake faɗa da shi.

Tare da hauhawar jijiyoyin jini, an wajabta maganin monotherapy. A wannan yanayin, kuna buƙatar ɗaukar 10 mg na "Hinapril" sau ɗaya a rana. Bayan makonni 3, an yarda da ƙaruwa a cikin kullun zuwa 20-40 MG. Za'a iya rarrabashi zuwa allurai 2 bayan tsawon lokaci daidai.

Idan an buƙata, kashi na miyagun ƙwayoyi ga mai haƙuri tare da hauhawar jini yana ƙaruwa zuwa 80 MG. Irin waɗannan matakan yawanci wajibi ne idan, bayan makonni 3 bayan farawa, ba a bayyane canje-canje masu kyau.

Game da ciwon koda ko mara nauyi, ana bada shawara don fara shan Hinapril tare da 5 MG. A duk lokacin da ake yin magani, ana buƙatar kasancewa ƙarƙashin kulawar ƙwararrun domin sanin ƙayyadaddun yanayin ci gaba da haƙuri a cikin haƙuri.

Idan halin da zuciya ke ciki bai canza ba, yawan maganin zai karu zuwa 40 MG kowace rana. Likitocin da ke rubuta bita game da miyagun ƙwayoyi sun tabbatar da canji a cikin yanayin don mafi kyau tare da irin wannan daidaitawa a cikin tsarin kulawa.

Yana da mahimmanci shan kwaya a lokaci guda.

Yi amfani da ƙuruciya da tsufa

An ba da magani ga mutanen da ba su cika shekara 18 ba tukuna. Sabili da haka, amfani da shi a lokacin ƙuruciya ba a yarda da shi ba.

Marasa lafiya waɗanda suka haɗu da shekaru 65 ya kamata su fara ɗaukar magani tare da sashi na 10 MG. Bayan haka, an yarda da ƙaruwarsa har zuwa lokacin da za a bayyana kyakkyawan sakamako na magani.

Kafin fara karatun, likitan mai haƙuri dole ne ya yi cikakken binciken a cikin asibiti. Wannan sharaɗin ne wanda ke ba da tabbacin amincin jiyyarsa tare da Hinapril.

Ya kamata a bincika tsofaffi marasa lafiya kafin su fara jiyya

Pathology na hanta da kodan

Marasa lafiya da cututtukan hanta da koda na iya ɗaukar magani, amma a ƙarƙashin cikakkiyar kulawa na likitan halartar. Irin wannan maganin yana halatta kawai ga wasu cututtukan da ke lalata aikin gabobin ciki. Idan akwai, kuna buƙatar saka idanu sosai akan sashi na "Hinapril" kuma a cikin kowane yanayi don haɓaka shi ba tare da buƙatar ba kuma samun izini daga ƙwararren likita.

Umarni na musamman

Umarnin don amfani da "Hinapril" ya ƙunshi umarni na musamman waɗanda dole ne a yi la’akari da su yayin tsara tsarin magani dangane da wannan magani.

Ba za a iya amfani da maganin a kowane lokaci na ciki ba. Bai kamata mata masu haihuwa su nisanta kansu da waɗanda ke nisantar amfani da hanyoyin hana haihuwa ta zamani yayin jima'i ba. Idan ciki ya faru kai tsaye yayin aikin Hinapril, to mara lafiyar ya kamata nan da nan ya watsar da ƙarin amfani. Da zaran an soke maganin, to lahanin cutar da zai yiwa tayin da mahaifiyar da ke jira.

An rubuta kararraki yayin da aka haifi yaro ba tare da wasu abubuwa marasa tabbas ba. A cikin irin wannan yanayi, ana kula da yaran da iyayensu mata suka sha wannan magani a hankali. Likitoci suna da sha'awar hawan jini na jariri.

Tare da taka tsantsan, an wajabta magunguna ga marasa lafiya waɗanda aka gano da nakasa ko aikin hepatic. Ana ɗaukar magani tare da irin wannan cututtukan a cikin tsayayyen ƙayyadaddun tsarin. Bugu da ƙari, mai haƙuri yana fuskantar kullun ga wasu gwaje-gwaje, waɗanda ke ba da izinin gano lokaci na lalacewa a cikin yanayin gabobin ciki na matsala saboda jiyya tare da Hinapril.

Hulɗa da ƙwayoyi

Idan kun sha miyagun ƙwayoyi tare da tetracycline a lokaci guda, zaku iya samun gagarumar raguwa a cikin ɗaukar abu na biyu. Wannan tasirin yana faruwa ne sakamakon aiki na musamman na carbonis magnesium, wanda yake aiki a matsayin kayan taimako a Hinapril.

Idan mai haƙuri ya ɗauki lithium tare da masu hana ACE, to abin da ke cikin abubuwan farko a cikin jijiyoyin jini yana ƙaruwa. Alamomin maye ne tare da wannan kayan shima yana haɓakawa saboda karuwar haɓakar sodium. Sabili da haka, ana buƙatar amfani da waɗannan kwayoyi tare da taka tsantsan idan ya cancanta, haɗin gwiwa.

An yarda da yin amfani da maganin diuretics tare da Hinapril lokaci daya. Amma a lokaci guda akwai karuwa a cikin tasirin hypotensive. Sabili da haka, ana buƙatar a hankali zaɓar sashi na magungunan biyu don guje wa rikice-rikice na lafiyar mai haƙuri.

Tare da taka tsantsan kuma a ƙarƙashin cikakken iko da matakin potassium a cikin jini, zaka iya ɗaukar magani a lokaci guda tare da kwayoyi waɗanda ke cikin rukunin masu yaduwar potassium. Abubuwan da ke cikin potassium da gishirin gishiri, waɗanda suke dauke da wannan sifar, suna cikin rukuni guda.

Tare da gudanar da aikin magani da barasa lokaci guda, an lura da karuwa a cikin aiki mai aiki "Hinapril".

Allunan akai-akai suna inganta tasirin ƙwayar, wanda yayi daidai da yawan wucewa

Jiyya tare da masu hana ACE na haifar da bayyanar cututtukan hypoglycemia a cikin marasa lafiya. An lura da wannan sabon abu a cikin mutane masu ciwon sukari waɗanda ke ɗaukar insulin ko hypoglycemic jamiái don amfani na ciki. Magungunan zai inganta sakamako ne kawai.

Yin maimaita amfani da miyagun ƙwayoyi a cikin adadin 80 MG tare da atorvastatin a cikin sashi na 10 MG ba ya haifar da manyan canje-canje a cikin aikin abu na biyu.

Magunguna na iya ƙaruwa da yiwuwar haɓaka leukopenia a cikin marasa lafiya waɗanda ke ɗaukar allopurinol, immunosuppressants, ko magungunan cytostatic.

Observedarfafa aikin mai aiki na Hinapril ana lura dashi lokacin da aka haɗu da shi tare da magungunan narkewa, magungunan motsa jiki na yau da kullun da magungunan antihypertensive.

Doubleari biyu na ayyukan RAAS yana haifar da sakamako na aliskiren ko masu hana ACE na lokaci daya. Ana lura da mummunan tasiri akan asalin yanayin rage karfin jini, kazalika da haɓakar hyperkalemia.

Specialwararrun kwararru suna ba da shawarar cewa marasa lafiya su guji haɗaka da maganin tare da aliskiren da magungunan da ke dauke da wannan abun, har da magungunan da ke hana RAAS a cikin halaye masu zuwa:

1. A gaban ciwon sukari mellitus tare da lalacewar gabobin da aka yi niyya, haka kuma ba tare da irin wannan rikicewar ba.
2. Idan akwai matsala na aiki na haya,
3. Tare da haɓaka yanayin hyperkalemia, wanda alamomi ke nunawa sama da mm mm 5 / l,
4. Tare da rauni na zuciya ko haɓakar hauhawar jini.

Magungunan da ke haifar da hanawa aiki a cikin ɓarna kashi yana haifar da yiwuwar agranulocytosis ko neutropenia.

Marasa lafiya waɗanda ke haɗuwa da miyagun ƙwayoyi tare da estramustine ko Dhib-4 inhibitors suna cikin haɗarin haɓakar angioedema.

Analogs da farashin

Ofaya daga cikin analogues na hinapril tare da abu guda mai aiki

Don siyan Hinapril a cikin kantin magani, dole ne a gabatar da takardar sayan magani daga likita zuwa ga kantin magani. Farashinsa ya dogara da adadin allunan a cikin kunshin da aka siya. Matsakaicin farashin maganin yana iyakance ga 80-160 rubles. Za'a iya samun cikakken farashin farashin magunguna a cikin kantin magani.

Don wasu dalilai, likitoci sun canza maganin da aka wajabta wa mara lafiya don kamantarsa. Ana ba da waɗannan magunguna masu zuwa don maye gurbin Hinapril:

Analogs kawai likitan halartar ne za'a iya zabar sa. Bai kamata mai haƙuri ya yi wannan da kansa ba, saboda yana haɗarin yin kuskure wanda zai cutar da jiyya da lafiyar sa gabaɗaya.

Idan saboda wasu dalilai mara lafiya bai dace da magani tare da Hinapril ba, ya kamata ya sanar da likitan halartar game da hakan. Zai yi ƙoƙarin zaɓar magani mafi dacewa a gare shi, yana mai da hankali kan matsalar haƙuri da halin lafiyar yanzu. A matsayinka na mai mulki, irin wannan buƙatar ta taso idan mai haƙuri yana da contraindications don ɗaukar magunguna ko haɓakar halayen da ba shi da kyau daga jiki zuwa kayan aiki na miyagun ƙwayoyi.

Khinapril ya fara karɓar ta har ma lokacin da yake jinya a asibiti. Likita koyaushe yana lura da yanayin na, saboda yana tsoron mummunan sakamako masu illa saboda matsalolin koda. Abin farin, babu rikitarwa da suka nuna kansu. Gabaɗaya, na sha maganin har tsawon watanni 6. Sau da yawa, akan shawarar likita, ya kara yawan sashi. Yankin “Khinapril” ya isa haka nan, tunda ya taimaka wajen magance matsalar tare da cutar hawan jini, wacce ke ta da damuwa a 'yan shekarun nan. Kodayake lokaci-lokaci, hawan jini har yanzu yana hauhawa, kodayake ba kamar yadda yake ba kafin farawar maganin.

Na fara samun matsaloli tare da matsi sosai. Kodayake yawanci irin waɗannan cututtukan suna damun tsofaffi. Likitan ya ba da shawarar yakar su da Hinapril. Nan da nan ya yi gargaɗi game da yiwuwar yiwuwar sakamako masu illa, saboda haka ya ba da ɗan ƙaramin adadin maganin. Na yi amfani da magani a matsayin farjin kulawa. Komai na tafiya dai-dai. Amma ba da jimawa ba, baccin rashin dalili ya fara damuwa, kodayake na yi ƙoƙarin samun isasshen barci. Wannan shine kawai tasirin sakamako wanda ya yiwa kansa ji. Idan yanayin bai inganta ba, zan nemi likita ya ba ni misalin "Hinapril", tunda irin wannan yanayin bai dace da ni ba.

Tsarin ilimin rayuwa (ICD-10)

Pharmacodynamics

ACE wani enzyme ne wanda ke daukar nauyin juyowar angiotensin I zuwa angiotensin II, wanda ke da tasirin vasoconstrictor kuma yana kara sautin jijiyoyin jiki, gami da saboda haɓakar narkewar aldosterone ta hanyar adrenal bawo. Quinapril gasa yana hana ACE kuma yana haifar da raguwa a cikin ayyukan vasopressor da ɓoyewar aldosterone.

Kawar da mummunan tasirin angiotensin II akan renin ɓoye ta hanyar maginin yana haifar da karuwa a cikin aikin renon plasma. A lokaci guda, raguwar hauhawar jini yana tare da raguwa a cikin bugun zuciya da juriya daga tasoshin koda, yayin da canje-canje a cikin ƙwayar zuciya, fitarwa na zuciya, zubar jini na jini, ƙirar ƙirar ƙasa da ƙirar filtration ba shi da mahimmanci ko ba ya nan.

Hinapril yana ƙaruwa da haƙuri.Tare da yin amfani da tsawan lokaci, yana haɓaka haɓakar juji na ƙwayar myocardial a cikin marasa lafiya tare da hauhawar jijiya, inganta haɓakar jini zuwa isyomic myocardium. Ingantaccen jijiyoyin jini da na jini koda. Yana rage hadewar platelet. Farawar aiki bayan shan guda ɗaya shine bayan awa 1, matsakaicin bayan sa'o'i 2-4, tsawon lokacin aikin ya dogara da girman adadin da aka ɗauka (har zuwa awanni 24). Sakamakon da aka ambata a asibiti yana tasowa makonni da yawa bayan farawar likita.

Haihuwa da lactation

Yin amfani da miyagun ƙwayoyi Hinapril-SZ yana contraindicated lokacin daukar ciki, a cikin mata masu shirin daukar ciki, da kuma a cikin mata masu haihuwa da ba sa amfani da hanyoyin ingantaccen maganin hana haihuwa.

Matan mata masu haihuwa da suke shan Hinapril-SZ ya kamata suyi amfani da hanyoyin ingantattun maganin hana haihuwa.

Lokacin da ake bincika ciki, ya kamata a dakatar da miyagun ƙwayoyi Hinapril-SZ da wuri-wuri.

Yin amfani da inhibitors na ACE yayin daukar ciki yana haɗuwa da haɓakar haɗarin mahaifa a cikin jijiyoyin zuciya da jijiyoyin mahaifa. Bugu da kari, a kan bango na shan inhibitors na ACE a lokacin daukar ciki, an bayyana batun oligohydramnios, haihuwar haihuwa, haihuwar yara tare da jijiyoyin jini, cututtukan koda (wanda ya hada da gazawar cutar koda), kwanciyar hankali na cranial, kwangilar hannu, craniofacial malform, cututtukan huhun zuciya, komawar mahaifa. ci gaba, buɗaɗɗen ductus arteriosus, har ma da mutuwar tayi da mutuwar haihuwa. Sau da yawa, ana gano oligohydramnios bayan tayin ya lalata ba tare da matsala ba.

Ya kamata a lura da jarirai waɗanda aka fallasa su ga hanawar ACE a cikin utero don gano cututtukan jijiyoyin jini, oliguria da hyperkalemia. Lokacin da oliguria ya bayyana, ya kamata a kula da hawan jini da ƙanshin koda.

Maganin Hinapril-SZ bai kamata a rubuta shi ba yayin shayarwa saboda gaskiyar cewa masu hana ACE, ciki har da hinapril, sun shiga cikin madarar nono zuwa iyakataccen iyaka. Ba da yiwuwar haɓaka mummunan lamari a cikin jariri, dole ne a soke maganin Hinapril-SZ yayin shayarwa ko kuma dakatar da shayarwa.

Fom ɗin saki

Allunan da aka sanya fim, 5 MG, 10 MG, 20 MG, 40 MG. Allunan 10 ko 30. a cikin bakin tabarmar marmari. Allunan 30 a cikin kwalba ta polymer ko kuma a cikin kwalbar polima. Kowace tulu ko kwalba, 3, 6, blister fakitin allunan 10. ko fakiti 1, 2 na allunan 30. sanya shi a cikin kwali.