Magungunan Trazhenta: umarnin, sake dubawa game da masu ciwon sukari da tsada

Ana yin wannan magani a cikin nau'ikan allunan zagaye na launin ja mai haske. Kowannensu ya yanke gefuna biyu da bangarorin biyu masu gogewa, a ɗayan ɗayan abin amfani da alamar kamfanin, a ɗayan kuma akwai alamar "D5".

Kamar yadda aka fada a cikin umarnin zuwa Trazhent, babban abun ciki na kwamfutar hannu ɗaya shine lignagliptin tare da ƙara 5 MG. Elementsarin abubuwa sun haɗa da sitaci na masara (18 mg), copovidone (5.4 mg), mannitol (130.9 mg), sitaci pregelatinized (18 mg), magnesium stearate (2.7 mg). Haɗin harsashi ya haɗa da ruwan hoda opadra (02F34337) 5 MG.

Kuna iya siyan Trazhenta a cikin murhun alummula (a cikin allunan guda 7). Don sauƙi na amfani, suna cikin kwalin kwali, inda zaku iya samun blister 2, 4 ko 8. 1 blister zai iya riƙe allunan 10 (a wannan yanayin, guda 3 a cikin kunshin).

Tasirin magungunan Trazhenty

Babban sinadari mai aiki na Trazhenta shine mai hana inzirin enzyme dipeptidyl peptidase-4 (DPP-4), wanda da sauri yana lalata jijiyoyin ciki (GLP-1 da HIP) wanda ya zama dole ga jikin ɗan adam don kula da yawan adadin glucose a ciki. Haɗarin waɗannan kwayoyin halittar guda biyu suna ƙaruwa nan da nan bayan cin abinci. Idan daidaitaccen glucose na al'ada ko dan ƙarami ya kasance a cikin jini, to a wannan yanayin GLP-1 da HIP suna haɓaka biosynthesis na insulin, da kuma narkarwar da ita. GLP-1 shima yana taimakawa wajen rage samarda glucose a cikin hanta.

Analogs na Trazhenta da miyagun ƙwayoyi da kanta suna ƙara yawan abubuwan haɗin gwiwa ta hanyar aikin su kuma, rinjayar su, tilasta su su ci gaba da aiki a cikin ɗan lokaci. A cikin sake nazarin Trazhent, an lura cewa wannan magani yana taimakawa ƙara yawan glucose-dogara da insulin kuma yana rage ɓoyewar glucagon, don haka yana daidaita matakin glucose a cikin jini.

Alamu don amfani

A cikin sake dubawa ga Trazhent, an faɗi cewa an sanya wannan magani ga marasa lafiya waɗanda ke da nau'in ciwon sukari na II, da kuma:

• Sanya azaman magani ɗaya wanda zai yuwu ga marasa lafiya da rashin isasshen sarrafa glycemic, wanda ke faruwa saboda abinci ko motsa jiki.
• Tare da rashin haƙuri don metformin ko a cikin abin da ya faru da haƙuri haƙuri daga gazawar na koda kuma an haramta shi sosai a dauki metformin.
• Ana iya amfani dashi tare da metformin, abubuwan da suka dace na sulfonylurea ko thiazolidinedione lokacin jiyya tare da abinci, monotherapy tare da waɗannan kwayoyi, da kuma wasanni ba su ba da sakamakon da ake so ba.

Ta yaya miyagun ƙwayoyi ke aiki?

Kwayoyin halittun da ke cikin jiki suna da hannu kai tsaye don rage glucose zuwa matakin kimiyyar lissafi. Theiraƙƙarin hankalinsu yana ƙaruwa yayin shigar da glucose a cikin tasoshin. Sakamakon aikin incretins shine ƙara haɓaka aiki na insulin, raguwa a glucagon, wanda ke haifar da raguwa cikin glycemia.

An lalata hanzarin incretins ta hanyar enzymes na musamman DPP-4. Magungunan Trazhenta suna da ikon ɗaure wa waɗannan enzymes, rage jinkirin ayyukansu, sabili da haka, tsawanta rayuwar incretins da ƙara ƙaddamar da insulin a cikin jini a cikin ciwon sukari na mellitus.

Amfani mara izini na Trazhenta shine cire abu mai aiki akasari tare da bile ta hanjin hanji. Dangane da umarnin, ba fiye da 5% na linagliptin da ke cikin fitsari ba, har ƙasa da metabolized a cikin hanta.

Dangane da masu ciwon sukari, amfanin Trazhenty sune:

• shan miyagun ƙwayoyi sau ɗaya a rana,
• An wajabta duk mara lafiya sau daya,
• ba a bukatar daidaita sakin jiki don cututtukan hanta da kodan,
• babu ƙarin gwaje-gwaje da ake buƙata don nada Trazhents,
• maganin ba mai guba bane ga hanta,
• sashi ba ya canzawa yayin shan Trazhenty tare da wasu kwayoyi,
• hulɗa da magani na linagliptin kusan ba ya rage tasiri. Ga masu ciwon sukari, wannan gaskiyane, tunda dole sai sun sha kwayoyi da yawa a lokaci guda.

Sashi da nau'in sashi

Trazhenta na miyagun ƙwayoyi yana samuwa a cikin nau'ikan allunan a cikin launin launi mai zurfi. Don kare ƙarancin fakes, ana nuna alamar kasuwanci ta masana'anta, Beringer Ingelheim Group of Kamfanoni, a gefe guda, kuma ana matsa alamun D5 a ɗayan.

Kwamfutar hannu a cikin fim ɗin fim, ba a bayar da rabo ba cikin kayan. A cikin kunshin da aka sayar a Rasha, allunan 30 (3 blisters of 10 inji mai kwakwalwa). Kowace kwamfutar hannu ta Trazhenta ta ƙunshi linigliptin 5 MG, sitaci, mannitol, magnesium stearate, dyes. Umarnin don amfani yana samar da cikakken jeri na kayan taimako.

Umarnin don amfani

Game da ciwon sukari mellitus, shawarar da aka bayar na yau da kullun shine 1 kwamfutar hannu. Kuna iya sha shi a kowane lokaci da ya dace, ba tare da wata alaƙa da abinci ba. Idan an ba da magani na Trezhent ban da metformin, ƙwayar ta ragu ba ta canzawa.

Idan ka rasa kwaya, zaka iya ɗaukar ta a wannan rana. An haramta shan Trazhent a kashi biyu, koda kuwa an rasa liyafar a ranar da ta gabata.

Lokacin da aka yi amfani da shi tare da glimepiride, glibenclamide, gliclazide da analogues, hypoglycemia yana yiwuwa. Don hana su, Trazhenta ya bugu kamar dā, kuma ana rage kashi ɗaya na sauran kwayoyi har sai an sami isasshen ƙwayar cuta. A cikin mafi ƙarancin kwanaki uku daga farkon shan Trazhenta, ana buƙatar karuwar glucose mai ƙarfi, tunda tasirin maganin yana haɓaka hankali. Dangane da sake dubawa, bayan zabar sabon kashi, yawan ci gaba da kuma ƙarfin hypoglycemia ya zama ƙasa da farkon farawa tare da Trazhenta.

Hanyoyin hulɗa na miyagun ƙwayoyi dangane da umarnin:

A cikin wasu kwayoyi, ba a sami ma'amala da Trazhenta ba.

Me zai iya cutar da

Ana iya kulawa da sakamako masu illa na Trazenti yayin gwajin asibiti da kuma bayan siyar da magani. Dangane da sakamakon da suka samu, Trazhenta ya kasance ɗaya daga cikin amintattun jigilar jini na jini. Rashin haɗarin illa da ke tattare da shan magungunan anƙalla ne.

Abin sha'awa, a cikin rukuni na masu ciwon sukari waɗanda suka karɓi placebo (allunan ba tare da wani abu mai aiki ba), 4.3% sun ƙi magani, dalilin shine alamun sakamako masu illa. A cikin ƙungiyar da ta ɗauki Trazhent, waɗannan marasa lafiya ba su da ƙasa, 3.4%.

A cikin umarnin don amfani, duk matsalolin kiwon lafiya da masu ciwon sukari ke fuskanta yayin binciken an tattara su a cikin babban tebur. A nan, da kuma cututtuka, da kuma hoto ko bidiyo mai zagaya yanar gizo da sauri, har ma da cututtukan fata. Tare da babban yiwuwa Trazenta ba shine sanadin wannan take hakkin ba. An gwada lafiya da aikin monotherapy na Trazhenta, da haɗe shi da ƙarin wakilai na maganin cututtukan cututtukan fata. A kowane hali, ba a gano takamaiman sakamako masu illa ba.

Jiyya tare da Trazhenta ba shi da haɗari kuma cikin sharuddan hypoglycemia. Nazarin yana nuna cewa ko da a cikin masu ciwon sukari tare da tsinkaya zuwa saukad da sukari (tsofaffi waɗanda ke fama da cututtukan koda, kiba), yawan yawan ciwon sukari bai wuce 1% ba. Trazhenta ba ya cutar da aikin zuciya da jijiyoyin jini, ba ya haifar da ƙaruwa mai nauyi a hankali, kamar sulfonylureas.

Yawan abin sama da ya kamata

Singleari guda na 600 MG na linagliptin (Allunan 120 na Trazhenta) an yarda da su sosai kuma baya haifar da matsalolin kiwon lafiya. Ba a yi nazarin sakamakon ƙarin allurai a jiki ba. Dangane da halayen ƙwayar ƙwayar ƙwayar cuta, cire ƙwayoyin undigested daga ƙwayar gastrointestinal (lavage na ciki) zai zama ingantaccen ma'aunin idan an sami ƙarin yawan shayewa. Hakanan ana gudanar da aikin tiyata da lura da mahimman alamu. Ialarɓar ƙwaƙwalwa idan aka sami yawan yawaitar Trazent ba shi da tasiri.

Likita na Kimiyyar Kimiyya, Shugaban Cibiyar Nazarin Diabetology - Tatyana Yakovleva

Na yi shekaru da yawa ina nazarin ciwon sukari. Yana da ban tsoro yayin da mutane da yawa suka mutu, har ma da yawa suna zama masu rauni saboda cutar sankara.

Na yi hanzarin ba da labari mai daɗi - Cibiyar Binciken Endocrinological na Kwalejin Kimiyya ta Rasha ta sami nasarar inganta maganin da ke warkar da ciwon sukari gaba ɗaya. A yanzu, ingancin wannan magani yana gab da kashi 98%.

Wani albishir: Ma'aikatar Lafiya ta tabbatar da ɗaukar wani shiri na musamman wanda zai biya diyyar magunguna mai yawa. A Rasha, masu ciwon sukari har sai 18 ga Mayu (m) samun shi - Don kawai 147 rubles!

Contraindications

Allunan da aka yiwa rauni ba su amfani da su:

1. Idan mai ciwon sukari bashi da kwayoyin beta wanda zai iya samarda insulin. Dalilin na iya zama nau'in 1 na ciwon sukari ko kamannin ƙwayar cuta.
2. Idan kun kasance rashin lafiyan kowane ɗayan abubuwan kwaya.
3. A cikin tsananin rikitarwar cututtukan zuciya. Magungunan da aka amince da su don maganin ketoacidosis shine insulin cikin ciki don rage yawan glycemia da saline don gyara bushewar fata. Duk wani shirye-shiryen kwamfutar hannu an soke har sai yanayin ya daidaita.
4. Tare da shayarwa. Linagliptin zai iya shiga cikin madara, ƙwayar narkewa ta yaro, yayi tasiri akan aikin shi na metabolism.
5. A lokacin daukar ciki. Babu wani tabbaci game da yuwuwar shigar linzliptin ta shiga cikin mahaifa.
6. A cikin masu ciwon sukari karkashin shekara 18. Ba a yi nazarin tasirin jikin yara ba.

Amincewa da Trazhent ya kara sanya hankali ga kiwon lafiya, an ba Trazhent damar nada marassa lafiya wadanda suka girmi shekaru 80, tare da matsananciyar cuta da taushi. Amfani da haɗin kai tare da insulin da sulfonylurea na buƙatar sarrafa glucose, saboda zai iya haifar da hypoglycemia.

Abin da analogues za a iya maye gurbin

Trazhenta sabon magani ne, kariyar patent har yanzu tana kan shi, saboda haka haramun ne a samar da analogues a Rasha tare da jigon iri ɗaya. Dangane da inganci, aminci da kuma tsarin aiki, analogues na rukuni sun kasance kusa da Trazent - masu hana DPP4, ko gliptins. Dukkanin abubuwa daga wannan rukuni ana kiransu ƙare da -gliptin, saboda haka za'a iya rarrabe su cikin kwatancen magungunan ƙwayoyin cuta masu yawa.

Kwatanta halayen gliptins:

(ba a buƙata)

(da ake bukata)

Shirye-shiryen Sulfonylurea (PSM) sune analogues masu sauki na Trazhenta. Hakanan suna haɓaka aikin insulin, amma tsarin tasirin su akan ƙwayoyin beta sun sha bamban. Trazenta yana aiki ne kawai bayan cin abinci. PSM yana motsa sakin insulin, koda sukari na jini al'ada ne, saboda haka galibi suna haifar da cutar tarin fuka. Akwai tabbacin cewa PSM mummunan tasiri yana shafi yanayin ƙwayoyin beta. Magungunan Trazhenta a wannan batun ba shi da hadari.

Mafi zamani da marasa lahani na PSM sune glimepiride (Amaryl, Diameride) da glycazide mai tsawo (Diabeton, Glidiab da sauran alamun analogues). Amfani da waɗannan magunguna ƙananan farashi ne, wata na gudanarwa zai biya kusan 150-350 rubles.

Dokokin ajiya da farashi

Shirya Trazhenty farashin 1600-1950 rubles. Za ku iya siyan sa kawai ta hanyar takardar sayan magani. An haɗa da Linagliptin a cikin jerin magunguna masu mahimmanci (Mahimmancin Magunguna na Mahimmanci), don haka idan akwai alamun, masu ciwon sukari da ke rajista tare da endocrinologist zasu iya samun shi kyauta.

Ranar karewa na Trazenti shekaru 3 ne, yawan zafin jiki a wurin ajiya kada ya wuce digiri 25.

Tabbatar koya! Shin kuna tsammanin kulawa da kwayoyin hana daukar ciki da insulin shine hanya daya tilo da za'a iya sarrafa sukari a karkashinta? Ba gaskiya bane! Kuna iya tabbatar da wannan da kanku ta hanyar fara amfani da shi. kara karantawa >>

Magungunan Trazhenta: umarnin, sake dubawa game da masu ciwon sukari da tsada

Trazhenta wata sabuwar magani ce don rage yawan glucose na jini a cikin ciwon sukari, a Rasha an yi rajista a 2012. Abunda ke aiki na Trazhenta, linagliptin, ya kasance ɗaya daga cikin mafi aminci azuzuwan hypoglycemic jamiái - DPP-4 inhibitors. An yarda da su sosai, ba su da wata illa, kuma kusan ba sa haifar da ƙin jini.

Wani trazenta a cikin rukuni na kwayoyi tare da matakan kusa yana tsaye. Linagliptin yana da babban aiki, don haka a cikin kwamfutar hannu kawai 5 MG na wannan abun. Bugu da kari, kodan da hanta ba su shiga cikin keɓantarsa ​​ba, wanda ke nufin cewa masu ciwon sukari tare da ƙarancin waɗannan gabobin na iya ɗaukar Trazhentu.

Umarnin ya ba da izinin Trazent don a keɓe shi ga masu ciwon sukari masu fama da cutar 2 kawai. A matsayinka na mai mulki, magani ne mai layin 2, wato, an gabatar dashi cikin tsarin kulawa lokacin gyara abinci, motsa jiki, metformin a mafi kyawun ko mafi girman sashi zai daina bayar da isasshen diyya ga masu ciwon sukari.

Alamu don shigowa:

1. Ana iya tsara Trazhent a matsayin kawai hypoglycemic lokacin da metformin ba ta da haƙuri ko an hana amfani da shi.
2. Ana iya amfani dashi azaman wani ɓangare na ingantaccen magani tare da abubuwan da suka samo asali na sulfonylurea, metformin, glitazones, insulin.
3. Hadarin cututtukan hypoglycemia lokacin amfani da Trazhenta kadan ne, sabili da haka, an fi son magunguna ga marasa lafiya da ke haifar da haɗarin sukari mai haɗari.
4. Ofaya daga cikin mummunan sakamako kuma na kowa sakamakon ciwon sukari shine lalata aiki na keɓaɓɓen - nephropathy tare da haɓaka haɓakar koda. Zuwa wasu lokuta, wannan rikitarwa yana faruwa a cikin 40% na masu ciwon sukari, yawanci yakan fara asymptomatic. Thearfafa tasirin rikice-rikice yana buƙatar gyara tsarin kulawa, tunda yawancin kwayoyi suna cire kodan. Marasa lafiya dole su soke metformin da vildagliptin, rage sashi na acarbose, sulfonylurea, saxagliptin, sitagliptin. A zubar da likita sune kawai glitazones, glinids da Trazent.
5. Akai-akai tsakanin marasa lafiya da ciwon sukari da kuma nakasa aikin hanta, musamman ma hepatosis mai. A wannan yanayin, Trazhenta ita ce kawai magani daga masu hanawar DPP4, wanda umarnin ya ba da damar amfani ba tare da ƙuntatawa ba. Wannan gaskiya ne musamman ga tsofaffi marasa lafiya da ke da haɗarin hauhawar jini.

Fara daga Trazhenta, zaku iya tsammanin cewa haemoglobin mai narkewa zai ragu da kusan 0.7%. A hade tare da metformin, sakamakon ya fi kyau - kusan 0.95%.Shaidun likitocin sun nuna cewa maganin yana daidai da inganci a cikin marasa lafiya waɗanda ke fama da cututtukan ƙwayar cutar sankara kawai da kuma ƙwarewar cutar fiye da shekaru 5. Nazarin da aka gudanar a cikin shekaru 2 sun tabbatar da cewa tasiri na maganin Trazent ba ya raguwa da lokaci.

Kwayoyin halittun da ke cikin jiki suna da hannu kai tsaye don rage glucose zuwa matakin kimiyyar lissafi. Theiraƙƙarin hankalinsu yana ƙaruwa yayin shigar da glucose a cikin tasoshin. Sakamakon aikin incretins shine ƙara haɓaka aiki na insulin, raguwa a glucagon, wanda ke haifar da raguwa cikin glycemia.

An lalata hanzarin incretins ta hanyar enzymes na musamman DPP-4. Magungunan Trazhenta suna da ikon ɗaure wa waɗannan enzymes, rage jinkirin ayyukansu, sabili da haka, tsawanta rayuwar incretins da ƙara ƙaddamar da insulin a cikin jini a cikin ciwon sukari na mellitus.

Amfani mara izini na Trazhenta shine cire abu mai aiki akasari tare da bile ta hanjin hanji. Dangane da umarnin, ba fiye da 5% na linagliptin da ke cikin fitsari ba, har ƙasa da metabolized a cikin hanta.

Dangane da masu ciwon sukari, amfanin Trazhenty sune:

• shan miyagun ƙwayoyi sau ɗaya a rana,
• An wajabta duk mara lafiya sau daya,
• ba a bukatar daidaita sakin jiki don cututtukan hanta da kodan,
• babu ƙarin gwaje-gwaje da ake buƙata don nada Trazhents,
• maganin ba mai guba bane ga hanta,
• sashi ba ya canzawa yayin shan Trazhenty tare da wasu kwayoyi,
• hulɗa da magani na linagliptin kusan ba ya rage tasiri. Ga masu ciwon sukari, wannan gaskiyane, tunda dole sai sun sha kwayoyi da yawa a lokaci guda.

Trazhenta na miyagun ƙwayoyi yana samuwa a cikin nau'ikan allunan a cikin launin launi mai zurfi. Don kare ƙarancin fakes, ana nuna alamar kasuwanci ta masana'anta, Beringer Ingelheim Group of Kamfanoni, a gefe guda, kuma ana matsa alamun D5 a ɗayan.

Kwamfutar hannu a cikin fim ɗin fim, ba a bayar da rabo ba cikin kayan. A cikin kunshin da aka sayar a Rasha, allunan 30 (3 blisters of 10 inji mai kwakwalwa). Kowace kwamfutar hannu ta Trazhenta ta ƙunshi linigliptin 5 MG, sitaci, mannitol, magnesium stearate, dyes. Umarnin don amfani yana samar da cikakken jeri na kayan taimako.

Game da ciwon sukari mellitus, shawarar da aka bayar na yau da kullun shine 1 kwamfutar hannu. Kuna iya sha shi a kowane lokaci da ya dace, ba tare da wata alaƙa da abinci ba. Idan an ba da magani na Trezhent ban da metformin, ƙwayar ta ragu ba ta canzawa.

Idan ka rasa kwaya, zaka iya ɗaukar ta a wannan rana. An haramta shan Trazhent a kashi biyu, koda kuwa an rasa liyafar a ranar da ta gabata.

Lokacin da aka yi amfani da shi tare da glimepiride, glibenclamide, gliclazide da analogues, hypoglycemia yana yiwuwa. Don hana su, Trazhenta ya bugu kamar dā, kuma ana rage kashi ɗaya na sauran kwayoyi har sai an sami isasshen ƙwayar cuta. A cikin mafi ƙarancin kwanaki uku daga farkon shan Trazhenta, ana buƙatar karuwar glucose mai ƙarfi, tunda tasirin maganin yana haɓaka hankali. Dangane da sake dubawa, bayan zabar sabon kashi, yawan ci gaba da kuma ƙarfin hypoglycemia ya zama ƙasa da farkon farawa tare da Trazhenta.

Pharmacodynamics

Magunguna masu rage sukari da aka yi niyya don gudanar da maganin baka. Abin hanawa ne na enzyme DPP-4, wanda ke hana hormones na inclinin GLP-1 da HIP, wadanda ke da hannu a cikin tsari na metabolism metabolism: ƙara yawan ruɓa insulinƙananan matakin kamuwa da cutakashe kayayyakin glucagon. Ayyukan waɗannan kwayoyin halittar ba su daɗewa, saboda enzyme ya rushe su. Linagliptinsake haɗawa zuwa DPP-4, wanda ke ɗaukar tsawan aikin adana ayyukan da ƙara haɓaka matakan su. Amfani da shi a nau'in ciwon sukari na II yana haifar da raguwa a cikin matakan haemoglobin glucose cikin jinin azumi da bayan kayan abinci bayan awa 2.

Lokacin ɗauka tare da Metformin akwai haɓakawa a cikin sigogin glycemic, yayin da nauyin jiki ba ya canzawa. Haɗuwa da abubuwan da aka samo asali sulfonylureasmuhimmanci ragewa glycosylated haemoglobin.

Jiyya lignagliptin baya karuwa hadarin zuciya (infarction na zuciya, mutuwar zuciya).

Pharmacokinetics

Lokacin da aka sha shi da baki, yana sha da sauri kuma an yanke Cmax bayan sa'o'i 1.5. Ciwon biphasic ya ragu. Cin abinci baya shafar magunguna. Bioavailability shine 30%. Asa kawai marasa amfani da miyagun ƙwayoyi ne metabolized. Kimanin 5% an fesa a cikin fitsari, sauran (kusan 85%) - ta cikin hanji. Don kowane mataki na kasawar koda, babu buƙatar canza sashi. Hakanan, ba'a canza canjin kashi ba saboda lalacewar hanta na kowane digiri. Ba a yi nazarin karatun magungunan ƙwayoyin cuta a cikin yara ba.

Side effects

Idan ana amfani da magani azaman maganin tauhidi, da wuya sa:

Dangane da batun haɗin gwiwa, ana yawan lura da cutar hypoglycemia. Da wuya - maƙarƙashiya, maganin ciwon huhu, tari. Da wuya angioedemanasopharyngitis cututtukan mahaifanauyi basir, basir.

Haɗa kai

Amfani lokaci daya Metformin, koda a kashi mafi girma sama da warkewa, bai haifar da manyan canje-canje a cikin pharmacokinetics na magunguna biyu.

Hada amfani da Fankarinda baya tasiri sigogin magunguna na magunguna biyu.

Magungunan magungunan wannan magani ba su canzawa lokacin da ake amfani da su Glibenclamide, amma an rage raguwar asibiti a Cmax na glibenclamide da 14%. Babu wata muhimmiyar ma'amala da sauran hanyoyin kuma ana tsammanin. sulfonylureas.

Alkawarin guda biyu Ritonavira yana haɓaka Cmax na linagliptin sau 3, wanda ba shi da mahimmanci kuma baya buƙatar canjin kashi.

Aikace-aikacen hadin gwiwa Rifampicin yana haifar da raguwa a Cmax na linagliptin, sabili da haka, ingancin aikin asibiti ya ci gaba, amma ba a bayyana cikakke ba.

Amfani lokaci daya Digoxin ba ya shafar magungunansa.

Wannan magani yana da ɗan tasiri a kan magunguna. Simvastatinduk da haka, ba lallai ba ne a canza sashi.

Linagliptin ba ya canza magungunan magunguna maganin hana haihuwa.

Analogs na Trazent

A miyagun ƙwayoyi da ciwon guda aiki abu - Linagliptin.

Ana amfani da irin wannan sakamako da kwayoyi daga rukuni guda. Saxagliptin, Alogliptin, Sitagliptin, Karshen.

Nazarin Trazent

Masu hana DPP-4, waɗanda suka haɗa da miyagun ƙwayoyi Trazhenta, ba wai kawai suna nuna tasirin rage sukari ba, har ma yana da babban matakin aminci, tunda ba sa haifar da yanayin hauhawar jini da hauhawar nauyi. A halin yanzu, ana amfani da wannan rukunin magungunan a matsayin mafi alƙawara a cikin lura da ciwon sukari na II.

Mafi yawan binciken kasa da kasa sun tabbatar da ingantaccen inganci a tsarin magunguna daban-daban. Zai fi kyau a nada su a farkon jiyya CD na II nau'in ko a hade tare da wasu kwayoyi. An rubutasu sau da yawa a maimakon abubuwan ƙira na sulfonylurea a cikin marasa lafiya waɗanda ke da haɗari ga yanayin hypoglycemic.

Akwai sake dubawa da cewa an sanya magunguna a cikin hanyar monotherapy insulin juriya kuma Ya ƙãra nauyi. Bayan karatun watanni 3, an lura da asarar nauyi mai yawa. Yawancin bita-da-gani sun fito ne daga marasa lafiyar da suka karɓi wannan magani a zaman wani ɓangare na rikicewar jiyya. A cikin wannan haɗin, yana da wuya a kimanta tasiri da amincin rashin lafiyar sukari, tunda tasirin wasu kwayoyi yana yiwuwa. Kowane mutum yana lura da tasiri mai kyau akan nauyi - an lura da raguwa, wanda yake da matukar muhimmanci ga masu ciwon sukari.

An wajabta magungunan ga marasa lafiya na shekaru daban-daban, ciki har da tsofaffi, kuma a gaban cutar sankara, hanta da cututtuka na tsarin zuciya. Babban tasirin tasirin cutar shine nasopharyngitis. Masu amfani da masu lura sun lura da babban farashin magungunan, wanda ya iyakance amfani da shi, musamman ta masu ritaya.

Aikace-aikacen Trazhenty yayin daukar ciki da lactation

An haramtawa ɗaukar Trazent da analogues na Trazent yayin ciki da lactation. Gwaje-gwaje a kan dabbobi sun nuna cewa babban sinadaran kwayoyi yana shiga cikin madarar nono kuma yana da tasiri mara kyau ga ci gaban al'ada da rayuwar jariri.

A cikin lokuta masu bukatar shan linnliptin, tilas ne a daina shayarwa.

Umarni na musamman

Ba a sanya trazhenta ga mutanen da ke cikin ketoacidosis masu fama da ciwon sukari, da nau'in ciwon sukari na mellitus. Cases na hypoglycemia lokacin shan Trazhenta a matsayin magani daya zai iya zama daidai da waɗanda ke faruwa saboda placebo.

Nazarin likitanci ya nuna cewa da alama yiwuwar haɓaka ƙarancin ƙwayar cuta bayan ɗaukar Trazhenta tare da wasu kwayoyi waɗanda ba sa haifar da hypoglycemia kwatankwacinsu sun kasance iri ɗaya bayan amfani da placebo.

Abubuwan da suka samo asali na sulfonylureas suna ba da gudummawa ga ci gaban haɓakar ƙwayar cuta. Abin da ya sa, shan su tare da linagliptin, ya kamata ku yi hankali. A wasu halaye, likita na iya rage yawan abubuwan da aka samo na abubuwan samo asali na sulfonylurea.

Zuwa yau, babu karatun likita da aka rubuta wanda zaiyi magana game da hulɗa da Trazhenta da insulin. A cikin marasa lafiya da gazawar rashin lafiyar koda, Trazent an wajabta shi tare da sauran magunguna na hypoglycemic.

Ana rage yawan haɗuwar glucose idan kun dauki analogues Trazhenty ko ƙwayoyi kafin abinci. Saboda yuwuwar wahala a lokacin amfani da wannan magani, zai fi kyau kar a tuƙa mota.

Trazenta: farashin a cikin kantin magani na kan layi

Allunan mai rufin Trenta 5 MG 30 inji mai kwakwalwa.

KYAUTA 5mg 30 inji mai kwakwalwa. Allunan mai rufe fim

Shafin Trazenta. p.p.o. 5mg n30

Magungunan Trenta 5 MG 30 Allunan

Trazhenta tbl 5mg No. 30

Bayanai game da miyagun ƙwayoyi an samar da su, an bayar da su ne don dalilai na bayanai kuma baya maye gurbin umarnin hukuma. Kai magani yana da haɗari ga lafiya!

Yayin aiki, kwakwalwarmu tana amfani da adadin kuzari daidai da wutar fitila 10-watt. Don haka hoton gilashin haske sama da kanka a lokacin bayyanar tunani mai ban sha'awa ba ya da nisa da gaskiya.

Yawancin mata suna iya samun ƙarin jin daɗi daga tunanin kyakkyawan jikinsu a cikin madubi fiye da jima'i. Don haka, mata ku yi ƙoƙari don jituwa.

Yayin sneeze, jikinmu gaba ɗaya yana dakatar da aiki. Har zuciyar ta tsaya.

Cutar hanta ita ce mafi girman jikinmu. Matsakaicin nauyinta shine kilogiram 1.5.

Domin faɗi har ma da mafi guntu kuma mafi sauƙaƙan kalmomi, muna amfani da tsokoki 72.

Magunguna da yawa an fara tallata su azaman magunguna. Misali, a farko, an siyar da Heroin azaman maganin tari. Kuma likitoci sun ba da shawarar yin amfani da cocaine a matsayin maganin hana haihuwa da kuma hanyar wadatar da haƙuri.

Ya kasance hakan yana haɓaka jiki da oxygen. Koyaya, an rarraba wannan ra'ayin. Masana ilimin kimiyya sun tabbatar da cewa hayaniya, mutum yana sanya kwantar da hankali da haɓaka aikinsa.

A cikin 5% na marasa lafiya, maganin antidepressant clomipramine yana haifar da inzali.

Dangane da kididdigar, a ranakun Litinin, hadarin raunin baya yana ƙaruwa da 25%, da kuma haɗarin bugun zuciya - da kashi 33%. Yi hankali.

A yunƙurin fitar da mara lafiya, likitoci sukan yi nisa sosai. Don haka, alal misali, wani Charles Jensen a cikin shekarun daga 1954 zuwa 1994. ya tsira fiye da 900 aikin cirewar neoplasm.

A cewar masana kimiyya da yawa, hadadden bitamin ba su da amfani ga mutane.

Mutumin da ke shan magungunan maye a yawancin lokuta zai sake fuskantar wahala daga bacin rai. Idan mutum ya jimre da damuwa na kashin kansa, yana da kowane damar ya manta da wannan halin har abada.

Idan kayi murmushi sau biyu kawai a rana, zaku iya rage karfin jini da rage hadarin bugun zuciya da bugun jini.

Masana kimiyya daga Jami’ar Oxford sun gudanar da jerin karatuttuka, a lokacin da suka kai ga matsayin cewa cin ganyayyaki na iya zama illa ga kwakwalwar dan Adam, saboda hakan yana haifar da raguwa a yawanta. Saboda haka, masana kimiyya sun ba da shawarar kada su cire kifi da nama gaba daya daga abincin da suke ci.

Akwai syndromes na likita masu ban sha'awa, irin su sha'awar abubuwa. A cikin ciki na haƙuri ɗaya da ke fama da wannan matsala, an gano abubuwa 2500 na ƙasashen waje.

An san man kifi na shekaru da yawa, kuma a wannan lokacin an tabbatar da cewa yana taimakawa wajen rage kumburi, yana kawar da ciwon haɗin gwiwa, inganta haɓaka.

Menene ciwon sukari?

Wannan hanya ce ta tsarin endocrine, wanda sakamakon yawan glucose a cikin jinin mutum ya karu, tunda jiki ya rasa ikon shan insulin. Sakamakon wannan cututtukan suna da mummunar matsala - tafiyar matakai na rayuwa sun lalace, tasoshin, gabobin jiki da tsarin. Ofayan mafi haɗari da rashin ƙarfi shine ciwon sukari na nau'in na biyu. Wannan cuta ana kiranta babbar barazana ga bil'adama.

Daga cikin abin da ke haifar da mace-mace a cikin shekaru 20 da suka gabata, ya zo na farko. Babban abin da ke haifar da ci gaban cutar ana daukar shi a matsayin gazawar tsarin garkuwar jiki. Magungunan rigakafi an samar da su a cikin jiki waɗanda ke da lahani a cikin ƙwayoyin ƙwayar ƙwayar cuta. Sakamakon haka, glucose a cikin adadi mai yawa yana gudana cikin jini, yana da mummunan tasiri akan gabobin da tsarin sa. Sakamakon rashin daidaituwa, jikin yana amfani da kitsen a matsayin tushen makamashi, wanda ke haifar da karuwar halittar ketone, abubuwan guba ne. A sakamakon wannan, duk nau'ikan hanyoyin haɓaka da ke faruwa a cikin jiki suna rushewa.

Sabili da haka, yana da mahimmanci musamman lokacin da ake neman ciwo don zaɓin maganin da ya dace da kuma amfani da magunguna masu ƙima, alal misali, “Trazhentu”, sake duba likitoci da marasa lafiya game da abin da za'a iya samu a ƙasa. Hadarin ciwon sukari shine cewa na dogon lokaci bazai iya ba da bayyananniyar asibiti ba, kuma ana gano abubuwan da ke tattare da ƙimar sukari kwatsam ta hanyar bincike na gaba na gaba.

Sakamakon ciwon sukari

Masana kimiyya a duniya suna ci gaba da gudanar da bincike da nufin gano sababbin dabaru don ƙirƙirar magani wanda zai iya kayar da mummunan cutar. A cikin 2012, an yi rajistar magani na musamman a cikin ƙasarmu, wanda kusan ba sa haifar da sakamako masu illa sannan kuma haƙuri yana da haƙuri sosai. Bugu da ƙari, an yarda da shi don karɓan mutane da keɓaɓɓen renal da hepatic insufficiency - kamar yadda yake a rubuce a cikin bita na "Trazhent".

Babban haɗari shine rikice-rikice na ciwon sukari:

• rage a cikin ganuwa acuity har zuwa cikakken asara,
• gazawar aikin kodan,
• na jijiyoyin zuciya da cututtukan zuciya - cututtukan zuciya na zuciya, atherosclerosis, cututtukan zuciya na zuciya,
• ƙafafun ƙafa - purulent-necrotic tafiyar matakai, rauni na raunuka,
• bayyanar ulcers a kan dermis,
• fungal fata raunuka,
• neuropathy, wanda ke bayyana ta hanyar raɗaɗi, bawo da raguwa a cikin jijiyar fata,
• coma
• keta ayyukan ƙananan hanyoyin.

"Trazhenta": bayanin, abun da ke ciki

Ana samar da magani a cikin nau'in sashi kwamfutar hannu. Allunan zagaye na biconvex allunan da aka yanke suna da farin harsashi. A gefe ɗaya akwai alamar mai ƙira, wanda aka gabatar a cikin hanyar zane, a ɗayan - zane mai fasalin D5.

Abunda yake aiki shine linagliptin, saboda babban tasirinsa don kashi ɗaya, milligram biyar ya isa. Wannan bangaren, yana haɓaka samar da insulin, yana rage haɗarin glucagon.Tasirin yana faruwa na tsawon minti dari da ashirin bayan gudanarwa - bayan wannan lokacin ne ake lura da iyakar karfin sa a cikin jini. Wadanda suka kware wajan samar da allunan:

• magnesium stearate,
• pregelatinized da masara sitaci,
• mannitol mai diuretic ne,
• copovidone shine mai narkewa.

Shell ɗin ya ƙunshi hypromellose, talc, fenti ja (baƙin ƙarfe), macrogol, titanium dioxide.

Siffofin magani

A cewar likitocin, "Trazhenta" a cikin aikin asibiti ya tabbatar da ingancinsa a cikin lura da nau'in na biyu na cututtukan mellitus a cikin ƙasashe hamsin na duniya, ciki har da Rasha. An gudanar da bincike a cikin kasashe ashirin da biyu inda dubunnan marasa lafiya da ke dauke da nau'in ciwon sukari na biyu suka shiga cikin gwada maganin.

Saboda gaskiyar cewa maganin an cire shi daga jikin mutum ta hanyar hanji, kuma ba ta hanyar kodan ba, tare da lalacewa a aikinsu, ba a buƙatar daidaita sashi ba. Wannan shine ɗayan manyan bambance-bambance tsakanin Trazenti da sauran jami'ai masu maganin cututtukan fata. Amfani mai zuwa kamar haka: mara lafiya ba shi da hypoglycemia lokacin shan allunan, duka a hade tare da Metformin, kuma tare da monotherapy.

Game da masana'antun magungunan

Samun kwamfutar hannu na Trazhenta, sake dubawa wanda ake samun su kyauta, kamfanonin kamfanoni biyu ne ke aiwatar da su.

1. “Eli Lilly” - tsawon shekaru 85 yana daya daga cikin shugabannin duniya a fagen yanke shawara mai inganci da nufin tallafawa marasa lafiya da masu dauke da cutar sankarau. Kamfanin yana haɓaka kewayonsa koyaushe ta amfani da sabon binciken.
2. “Beringer Ingelheim” - ke jagorantar tarihinta tun daga shekarar 1885. Yana tsunduma cikin bincike, ci gaba, samarwa, har da siyar da magunguna. Wannan kamfani yana ɗaya daga cikin shugabannin duniya ashirin a fagen magunguna.

A farkon shekarar 2011, dukkan kamfanonin sun sanya hannu kan wata yarjejeniya kan hadin gwiwa a fannin cutar sankara, wanda ya sami ci gaba mai yawa a fannin magance cutar ta rashin lafiya. Dalilin ma'amala ita ce yin nazarin sabon haɗuwa da abubuwa masu guɓa huɗu waɗanda wani ɓangare ne na magungunan da aka tsara don kawar da alamun cutar.

M halayen

Yawancin magunguna da aka yi amfani da su don magance cututtukan sukari na mellitus na iya haifar da yanayin pathologies wanda matakan glucose a cikin jini ya ragu sosai, wanda ke haifar da haɗari mai mahimmanci ga mutum. "Trazhenta", a cikin bita-bita wanda aka ce ɗaukar shi ba ya haifar da hypoglycemia, togiya ce ga dokar. Wannan ana ɗaukarsa muhimmiyar fa'ida a kan sauran azuzuwan na hypoglycemic jamiái. Daga cikin halayen da ba za su iya faruwa ba yayin lokacin jiyya "Trazentoy", masu zuwa:

• maganin ciwon huhu
• tari yayi daidai
• nasopharyngitis,
• yawan tashin hankali
• hauhawar amylase plasma,
• kurji
• da sauransu.

Game da yawan abin sama da ya kamata, ana nuna matakan yau da kullun don cire wani magani mara amfani daga narkewa tare da maganin alamomin.

"Trazhenta": sake dubawa game da masu ciwon sukari da masu ilimin likita

An tabbatar da tasirin maganin sosai sau da yawa ta hanyar aikin likita da karatun ƙasa. Endocrinologists a cikin maganganun su sun ba da shawarar yin amfani da shi a hade hade ko azaman magani na farko-farko. Idan mutum yana da hali na hypoglycemia, wanda ke haifar da rashin abinci mai gina jiki da kuma aiki na jiki, yana da kyau a sanya “Trazent” a maimakon abubuwan da ake amfani da shi na sulfonylurea. Ba koyaushe zai yiwu a kimanta tasirin maganin ba idan an sha shi a hade, amma a gaba ɗaya sakamakon yana da kyau, wanda kuma masu haƙuri ke lura da shi. Akwai sake dubawa game da miyagun ƙwayoyi "Trazhenta" lokacin da aka ba da shawarar don kiba da juriya insulin.

Amfanin waɗannan magungunan maganin cututtukan ƙwayar cuta shine cewa basu bayar da tasu gudunmawa ba don karɓar nauyi, ba sa ɓarkewar haɓakar haɓakar jini, sannan kuma kar ku ƙara matsalolin koda. Trazhenta ya karu da aminci, wanda yake mahimmanci ga masu ciwon sukari. Sabili da haka, akwai adadin masu duba na kwarai game da wannan kayan aikin. Daga cikin ministocin lura da babban kudin da rashin yarda mutum.

Analog kwayoyi "Trazhenty"

Abubuwan sake dubawar da likitocin da ke shan wannan magungunan suka kasance mafi inganci Koyaya, ga wasu daidaikun mutane, saboda yawan zafin rai ko rashin haƙuri, likitoci sun ba da shawarar irin waɗannan magunguna. Wadannan sun hada da:

• "Sitagliptin", "Januvia" - marasa lafiya suna ɗaukar wannan magani azaman ƙari ga motsa jiki, abinci, don inganta ikon kula da glycemic state, ban da haka, an yi amfani da miyagun ƙwayoyi a haɗuwa da jiyya,
• "Alogliptin", "Vipidia" - galibi ana ba da shawarar wannan maganin idan babu tasirin abinci mai gina jiki, aikin jiki da monotherapy,
• "Saksagliptin" - ana samarwa a ƙarƙashin sunan kasuwanci "Ongliza" don magance nau'in na biyu na ciwon sukari, ana amfani dashi a cikin monotherapy kuma tare da sauran magungunan kwamfutar hannu da inulin.

Zaɓin analog ne kawai ta hanyar kula da endocrinologist, an hana canjin magani mai cin gashin kai.

Marasa lafiya tare da gazawar koda

"Madalla da ingantacciyar magunguna" - irin waɗannan kalmomin yawanci fara rave game da "Trazhent". Babban damuwa yayin shan magungunan maganin cututtukan ƙwaƙwalwar ƙwayar cuta koyaushe mutane sun dandana shi da raunin ƙwayoyin cuta, musamman waɗanda ke fama da cutar sankara. Tare da shigowar wannan magani a cikin cibiyar sadarwar kantin magani, marasa lafiya da ke fama da cututtukan koda sun yaba da shi, duk da babban farashin.

Saboda ƙwararren aikin magani na musamman, an rage darajar glucose sosai yayin ɗaukar maganin sau ɗaya kawai a rana a matakin warkewa na milligrams biyar. Kuma bashi da mahimmanci lokacin ɗaukar allunan. Magungunan yana cikin hanzari bayan an shiga cikin narkewa, ana lura da mafi girman hankali bayan sa'a daya da rabi ko awa biyu bayan gudanarwa. An cire shi cikin feces, wato, kodan da hanta basa shiga cikin wannan aikin.

Kammalawa

Dangane da sake duba masu ciwon sukari, ana iya ɗaukar Trazhent a kowane lokaci da ya dace, ba tare da la'akari da abinci mai gina jiki ba kuma sau ɗaya kawai a rana, wanda ake ɗauka babbar ƙari. Abinda ya kamata a tuna: ba za ku iya ɗaukar kashi biyu cikin kwana ɗaya ba. A haɗuwa da jiyya, ƙwayar "Trazhenty" ba ta canzawa. Bugu da kari, ba a buƙatar gyaransa ba idan akwai matsala tare da kodan. Allunan suna jure haƙuri sosai, halayen da ba a saba gani ba ne. "Trazhenta", sake dubawa wanda ke da matukar ƙarfin hali, ya ƙunshi wani abu na musamman da ke aiki wanda yake matuƙar tasiri. Babu karamin mahimmanci shine gaskiyar cewa maganin yana kunshe a cikin jerin magungunan da aka tsallake a cikin magunguna don magunguna kyauta.

Siffofin aikace-aikace

Ba'a amfani da Trazenta da analogues don magance cututtukan cututtukan cututtukan yara 2. Hakanan, umarnin yin amfani da miyagun ƙwayoyi ya haramta amfani da ita don maganin mata yayin haihuwar da ciyar da yaron.

Dangane da gwaje-gwajen, masu haɓakawa sun bayyana shigarwar abu mai aiki a cikin madarar nono, kuma a nan gaba zai iya shafar ci gaban tayin da rayuwar rayuwar jarirai. Idan akwai bukatar hanzarta gabatarwar linagliptin, yakamata a daina ciyar da ɗabi'ar jarirai nan da nan.