Nau'in na 2 na Ciwon Cutar na iya dakatar da Ci gaban Cutar Parkinson

A bara, wata ƙungiya daga Jami'ar Netherlands ta gano wani abu mai alaƙa da wani magani da aka yi amfani da shi don magance cututtukan mellitus. Muna magana ne game da yiwuwar gudanarwarta a cikin cutar ta Parkinson da kyakkyawan tasirin wannan magani. Magungunan yana cikin rukunan incretin mimetics, waɗanda suke sabon salo a cikin magunguna. An sake shi shekaru biyar da suka gabata. Babban abincinta yana ɓoye ne daga ɓoyayyen kayan maye - Ariffona puffer.

Shekaru huɗu bayan haka, waɗanda aka kashe a kan nazarin aikin guba, haɓaka shi da kuma gwaji, an tabbatar da abu mai amfani a matsayin mai inganci kuma an ba da magungunan kashewa - wani sabon magani game da ciwon sukari.

A kusan lokaci guda, sauran rukunin masana kimiyya sun sami damar tabbatar da cewa cutar ta Parkinson na iya farawa a cikin hanjin, daga baya kwakwalwa na iya shiga. Duk da kasancewar alamu daban-daban a wadannan cututtukan guda biyu, cututtukan suna da irin wannan hanyoyin a matakin kwayar halittar. Tunda sabon ƙwayar magungunan ta tsara aikin mitochondrial a cikin ƙwayoyin kwakwalwa kuma ta dawo da ikon ƙwayoyin don canza abubuwan da ke buƙata zuwa makamashi, likitoci sun yi hasashen cewa marasa lafiya da ke fama da cutar ta Parkinson za su sami daidaituwa game da ikon sarrafa abubuwan kariya masu haɗari. Saboda haka, kumburi zai ragu, kuma mutuwar jijiyoyi zai ragu.

Bayan wannan ka'idar ta bayyana, gudanar gwaji na asibiti. A sakamakon haka, masana kimiyya sun sami damar tabbatar da ingancin maganin a cikin yaki da cutar ta Parkinson. An gudanar da gwaji na asibiti a Burtaniya.

Mahimmanci

A cikin marasa lafiya da ke fama da cutar Parkinson, akwai lalacewa a hankali a cikin ƙwayoyin kwakwalwa waɗanda ke haifar da dopamine na hormone, sakamakon abin da rawar jiki ke haɓakawa, wahalar motsi da matsalolin ƙwaƙwalwa.

Dukkanin magunguna na yau suna taimakawa rage bayyanar cututtuka, amma ba zai iya hana mutuwar ƙwaƙwalwar ƙwayar cuta ba.

A cikin yanki daya, bazuwar, makafi-biyu, nazarin sarrafa-wuri, marasa lafiya da shekarunsu suka haɗu shekaru 25-75 da suka kamu da cutar idiopathic Parkinson sun haɗa. An ƙayyade tsananin cutar ta hanyar ka'idodin bankin Brain na Sarauniya kuma duk masu haƙuri suna da mataki na 2-5 a cewar Hoehn da Yahr yayin aikin likita na likita.

An raba marasa lafiya 1: 1 zuwa gungun maɓallin injections na exenatide (glucagon-like peptide-1 analogue) 2 MG ko placebo 1 kowane mako don makonni 48 ban da maganin al'ada. Lokacin magani ya biyo bayan hutun mako 12.

Canje-canje a cikin Rashin Tsarin Rage Tsagewar Rage Cutar Rage Cutar Cutar Kwayar cuta ta Kimiya (MDS-UPDRS) a sati 60 (rikice-mai-caloric) an yi amfani da shi azaman ƙarshen ingancin inganci.

Sakamako

Tun daga Yuni na 2014, lipid na 2015 ya haɗa da marasa lafiya 62 a cikin binciken, 32 daga cikinsu an haɗa su a cikin ƙungiyar exexenatide kuma 30 a cikin rukunin placebo. Binciken inganci ya haɗa da marasa lafiya 31 da 29, bi da bi.

• A mako 60, an samu ci gaba a cikin raunin rashin ƙarfi na motsi na ma'aunin MDS-UPDRS da maki 1.0 (95% CI −2.6 - 0.7) a cikin rukunin exenatide, idan aka kwatanta da taɓar da maki 2.1 (95% CI −0, 6 - 4.8) a cikin rukuni na sarrafawa, matsakaicin daidaitawa tsakanin ƙungiyoyin, −3.5 maki (95% CI −6.7 - −0.3, p = 0.0318).
• Abubuwan haɗari mafi haɗari a cikin duka rukuni sun kasance maganganu a wuraren allura da alamomin gastrointestinal. An yi rikodin sakamako masu illa guda 6 a cikin marasa lafiya na babban rukunin su, idan aka kwatanta da 2 daga sarrafawa, amma ba ɗayansu da aka ɗauka yana da alaƙa da binciken.

Kammalawa

Exenatide yana da tasirin gaske a kan raunin motsi a cikin marasa lafiya da ke fama da cutar ta Parkinson. A lokaci guda, har yanzu ba a sani ba ko miyagun ƙwayoyi suna shafar hanyoyin kwayar cutar cutar ko kuma kawai yana da tasirin bayyanar cututtuka na dindindin. Duk da yuwuwar exenatide, ana buƙatar ƙarin bincike, gami da tare da dogon lokacin kallo.

Sources:
Dilan Athauda, ​​Kate Maclagan, Simon S Skene, et al. KawaMasai. 03 Agusta 2017.