Miyagun ƙwayoyi Plevilox: umarnin don amfani

5 inji mai kwakwalwa. - blister (1) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (1) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (2) - fakitoci na kwali.
Guda 100 - jakunkuna na filastik (1) - gwangwani na polymer.
1000 inji mai kwakwalwa - jakunkuna na filastik (1) - gwangwani na polymer.
500 inji mai kwakwalwa - jakunkuna na filastik (1) - gwangwani na polymer.
7 inji mai kwakwalwa - blister (2) - fakitoci na kwali.
7 inji mai kwakwalwa - blister (1) - fakitoci na kwali.

Aikin magunguna

Wani wakili na rigakafi daga ƙungiyar fluoroquinolones, yana kashe ƙwayoyin cuta. Yana da ƙarfi a kan da yawa kewayon gram-tabbatacce kuma gram-korau microorganisms, anaerobic, acid-resistant da kuma atypical kwayoyin: Mycoplasma spp., Chlamydia spp., Legionella spp. Inganci a kan cututtukan ƙwayoyin cuta masu jure beta-lactams da macrolides. Yayi aiki da akasarin cututtukan ƙwayoyin cuta: gram-tabbatacce - Staphylococcus aureus (gami da nau'ikan da basu da hankali ga methicillin), Streptococcus pneumoniae (wanda ya haɗa da kwayar cutar penicillin da macrolides), Streptococcus pyogenes (rukunin A), gram-korau - Haemophilus mura da cututtukan da ba na beta-lactamase ba), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (wanda ya hada da rashin samar da beta da lactamase wanda ba shi da beta-lactamase), Escherichia coli, Enterobacter cloacae, Chlamydia pneumonia. Dangane da bincike-binciken vitro, kodayake ƙananan ƙwayoyin da aka lissafa a ƙasa suna kula da moxifloxacin, duk da haka, amincinsa da tasirinsa a cikin magance cututtukan cututtuka ba a kafa su ba. Gram-tabbatacce kwayoyin: Streptococcus milleri, Streptococcus mitior, Streptococcus agalactiae, Streptococcus dysgalactiae, staphylococcus cohnii, staphylococcus epidermidis (ciki har da damuwa, methicillin m), staphylococcus haemolyticus, staphylococcus hominis, staphylococcus saprophyticus, staphylococcus simulans, Corynebacterium diphtheriae. Kwayoyin gram-korau: Bordetella pertussis, Klebsiella oxytoca, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter Intermedius, Enterobacter nazaki, Proteus mirabilis, kariya ta kariya, Morganella morganii, Providencia rettgeri, Providencia stuartii. Anaerobic microorganisms: Bacteroides distasonis, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaornicron, Bacteroides uniformis, Fusobacterium spp, Porphyromonas spp, Porphyromonas anaerobius, Porphyromonas asaccharolyticus, Porphyromonas Magnus, Prevotella spp, Propionibacterium spp, Clostridium perfringens, Clostridium .... ramosum. Orarancin ƙananan ƙwayoyin cuta: Legionella pneumophila, Caxiella burnettii.

Tubalan topoisomerases II da na IV, enzymes wadanda ke tafiyar da abubuwan topological na DNA, kuma suna da nasaba da kwayar halittar DNA, gyarawa, da kuma kwayar halitta. Tasirin moxifloxacin ya dogara da maida hankali ne cikin jini da kyallen takarda. Imumarancin ƙananan ƙwayoyin cuta kusan ba su bambanta da ƙananan abubuwan hana ƙwaƙwalwa ba.

Hanyoyin haɓaka ayyukan haɓakawa, hana aiki da penicillins, cephalosporins, aminoglycosides, macrolides da tetracyclines, basu tasiri ayyukan hana ƙwayoyin cuta na moxifloxacin. Babu jurewa tsakanin moxifloxacin da wadannan kwayoyi. Ba a lura da matakan plasmid-matsakaiciyar juriya na cigaba ba. Gabaɗaya yanayin juriya yana ƙasa. Binciken in vitro ya nuna cewa juriya ga moxifloxacin yakan zama sannu a hankali sakamakon jerin maye gurbi. Tare da maimaitawa ga microorganisms tare da moxifloxacin a cikin ƙananan abubuwan hanawa, alamu na BMD kawai ƙara haɓaka. An lura da juriya tsakanin kwayoyi tsakanin ƙwayoyin fluoroquinolone. Koyaya, wasu ƙwayoyin-gram-tabbatacce da anaerobic microorganisms waɗanda suke tsayayya da sauran fluoroquinolones suna kula da moxifloxacin.

Pharmacokinetics

Bayan gudanar da baki, moxifloxacin yana tunawa da sauri kuma kusan gaba daya. Bayan kashi daya na moxifloxacin a kashi 400 MG C max a cikin jini ana samunsa tsakanin awa 0,5-4 kuma shine 3.1 mg / L.

Bayan jiko guda ɗaya a kashi na 400 MG don 1 h, an isa C max a ƙarshen jiko kuma shine 4.1 mg / l, wanda yayi daidai da karuwar kusan 26% idan aka kwatanta da darajar wannan mai nuna alama yayin ɗauka ta baka. Tare da infusions na IV da yawa a cikin adadin 400 MG na 1 hour, C max ya bambanta a cikin kewayon daga 4.1 mg / l zuwa 5.9 mg / l. Matsakaicin C ss na 4.4 mg / L an kai shi a ƙarshen jiko.

Cikakken bayanin bioavailability kusan kashi 91%.

Magungunan magani na moxifloxacin lokacin da aka ɗauki su a allurai guda ɗaya daga 50 MG zuwa 1200 MG, haka kuma a cikin adadin 600 mg / rana tsawon kwanaki 10, layin ne.

An cimma matsayin daidaituwa tsakanin kwanaki 3.

Haɗin zuwa sunadarai na jini (galibi albumin) kusan kashi 45%.

Moxifloxacin an rarraba shi da sauri a cikin gabobin da kyallen takarda. V d kusan 2 l / kg.

Babban adadin moxifloxacin, wanda ya wuce wadanda ke cikin plasma, an kirkireshi ne a cikin huhu na huhu (gami da alveolar macrophages), a cikin mucous membrane na bronchi, a cikin sinuses, a cikin kyallen takarda mai laushi, fata da kuma tsarin tsinke, cutarwa na kumburi. A cikin ruwa mai shiga tsakanin ciki da cikin gaɓa, an ƙaddara magungunan ta hanyar da babu tsari, wanda ba sinadarin gina jiki ba, a babban taro sama da na plasma. Bugu da kari, ana tantance babban hadadden abu mai aiki a jikin gabobin ciki da na hanjin ciki, da kuma cikin kashin jikin mace.

Biotransformed zuwa ƙwayoyin sulfo mara aiki da glucuronides. Moxifloxacin ba biotransformed da enzymes hanta microsomal na tsarin cytochrome P450.

Bayan wucewa ta kashi na 2 na biotransformation, moxifloxacin an cire shi daga jiki ta hanyar kodan kuma ta cikin hanji, duka ba canzawa ba kuma a cikin nau'ikan kwayoyin sulfo marasa aiki da glucuronides.

An keɓance shi a cikin fitsari, haka kuma tare da feces, duka ba su canzawa ba kuma a cikin nau'i na metabolites marasa aiki. Tare da kashi ɗaya na 400 MG, kusan 19% an cire shi a cikin fitsari, kimanin 25% tare da feces. T 1/2 shine kimanin awa 12. Matsakaicin tsabtacewa bayan gudanarwa a kashi na 400 MG shine daga 179 ml / min zuwa 246 ml / min.

Alamu don amfani

Cututtukan cututtukan ciki da na ƙananan jijiyoyin ƙwayar cuta: matsanancin sinusitis, rashin ƙarfi na mashako na kullum, cututtukan fata da ke addabar al'umma, cututtukan fata da ƙira mai taushi, cututtukan ciki mai rikitarwa, ciki har da cututtukan da ke lalacewa ta hanyar cututtukan ƙwayoyin cuta da yawa, cututtukan kumburi marasa illa na gabobin pelvic.

Yadda ake amfani: sashi da hanya na jiyya

A ciki ko a cikin nau'i na jiko na ciki (sannu a hankali, sama da minti 60) - 400 MG 1 lokaci ɗaya kowace rana. An hadiye kwamfutar hannu gaba daya, ba tare da taunawa ba, komai abincin. Hanya na kulawa don ɓarna da mashako na kullum - kwanaki 5, ciwon huhu na hanji na al'umma - kwanaki 10, matsanancin sinusitis, cututtukan fata da kyallen takarda mai laushi - kwana 7, tare da rikitarwa na ciki-ciki cikin kwanaki 5-14 (iv tare da canzawa zuwa m kulawa) , cututtukan kumburi marasa illa na gabobin pelvic - kwanaki 14.

Ba lallai ba ne a canza jigilar magunguna a cikin tsofaffi marasa lafiya da ke fama da cutar hepatic (rukunin A, B akan girman Yara-Pugh) da / ko na renal (ciki har da CC ƙasa da 30 ml / min / 1.73 sq. M).

Side effects

Sau da yawa - 1-10%, da wuya - 0.1-1%, musamman wuya - 0.01-0.1%.

Daga tsarin narkewa: sau da yawa - ciwon ciki, dyspepsia (ciki har da flatulence, tashin zuciya, amai, maƙarƙashiya, zawo), ƙara yawan aiki na "hanta" transaminases, da wuya - bushewar mucous membrane na bakin ciki, candidiasis na bakin mucosa, anorexia, stomatitis, glossitis, karuwar gamma-glutamintransferase, matsanancin rauni - gastritis, disloration na harshe, dysphagia, jaundice na yau da kullun.

Daga gefen tsarin juyayi: sau da yawa - matsananciyar damuwa, ciwon kai, da wuya - asthenia, rashin bacci ko nutsuwa, juyayi, damuwa, tashin hankali, damuwa, da wuya - hallucinations, depersonalization, ƙara sautin tsoka, rashin daidaituwa game da motsi, tashin hankali, tashin hankali, tashin hankali, Labarin nutsuwa, tashin hankali, tashin hankali, magana, rashin fahimta, rashin damuwa, rashi, damuwa.

A ɓangare na gabobin azanci: sau da yawa - canji na dandano, da wuya sosai - raunin gani, amblyopia, asarar dandano mai ƙanshi, parosmia.

Daga CCC: da wuya - tachycardia, hauhawar jini, bugun jini, ciwon kirji, tsawaita ta Tsakanin Q-T, da wuya - saukar karfin jini, jijiyoyin bugun jini,

Daga tsarin numfashi: da wuya - karancin numfashi, da kyar - asma.

Daga tsarin musculoskeletal: da wuya - arthralgia, myalgia, da wuya sosai - ciwon baya, ciwon kafa, arthritis, tendopathy.

Daga tsarin jijiyoyin jiki: da wuya - candidiasis na farji, farji, da wuya - wuya a cikin ƙananan ciki, kumburin fuska, taɓarɓarewar farji, gurguwar aiki na aiki.

Allergic halayen: da wuya - kurji, itching, musamman rare - urticaria, anaphylactic shock.

Abubuwan da suka shafi gida: sau da yawa - edema, kumburi, jin zafi a wurin allurar, da wuya - phlebitis.

Laboratory binciken: rare - leukopenia, ta ƙara prothrombin lokaci, eosinophilia, thrombocytosis, ta ƙara amylase aiki, ne musamman rare - asarar taro thromboplastin lokaci, prothrombin lokaci raguwa, thrombocytopenia, anemia, hyperglycemia, hyperlipidemia, hyperuricemia, ta ƙara LDH aiki. Ba a tabbatar da haɗin gwiwa game da shan miyagun ƙwayoyi ba: karuwa ko raguwa a cikin hematocrit, leukocytosis, erythrocytosis ko erythropenia, raguwa a cikin taro na glucose, Hb, urea, karuwa a cikin ayyukan alkaline phosphatase.

Sauran: da wuya - candidiasis, rashin jin daɗi gaba ɗaya, gumi.

Umarni na musamman

Yayin jiyya tare da fluoroquinolones, kumburi da rushewar jijiya na iya haɓaka, musamman a cikin tsofaffi marasa lafiya da kuma a cikin marasa lafiya da ke karbar corticosteroid concomitant. A alamun farko na jin zafi ko kumburi da jijiyoyin jiki, ya kamata marasa lafiya su dakatar da jiyya tare da rage ƙarfin abin da ya shafa.

Akwai hulɗa ta kai tsaye tsakanin haɓakar ƙwaƙwalwar moxifloxacin da karuwa a cikin tsaka-tsakin Q-T (haɗarin haɓaka ƙwaƙwalwar ƙwayar ventricular, ciki har da torsades de pointes). Sakamakon wannan, shawarar da aka ba da shawarar (400 MG) bai kamata ya wuce da kuma jiko ya kamata ya zama da sauri (aƙalla minti 60).

Game da cutar zazzabin cizon sauro yayin magani, ya kamata a dakatar da maganin.

Haɗa kai

Antacids, ma'adanai, multivitamins yana lalata sharar ciki (saboda samuwar chelate hadaddun abubuwa tare da polyvalent cations) da rage maida hankali na moxifloxacin a cikin plasma (gudanar da lokaci daya zai yuwu a lokaci na 4 hours kafin ko 2 sa'o'i bayan shan moxifloxacin).

Amfani da kwanciyar hankali tare da wasu abubuwan quinolones yana ƙara haɗarin tsawan tazara na Q-T.

Da ɗanɗani ya shafi sigogin magunguna na digoxin.

GCS yana kara haɗarin tendovaginitis ko lalatawar jijiya.

Maganin jiko ya dace da hanyoyin samfuran magunguna masu zuwa: 0.9% da mafitar NaCl 1 na molar, ruwa don allura, maganin dextrose (5, 10 da 40%), maganin 20 xylitol, maganin Ringer, Ringer-lactate, 10% Aminofusin bayani, bayani Yonosteril.

Rashin jituwa tare da mafita na NaCl 10 da 20%, 4.2 da 8.4% Na bicarbonate bayani.

Formaddamar da tsari da abun da ke ciki

Tsarin sakin magungunan shine allunan da aka rufe fim. Kowane kwamfutar hannu ta ƙunshi 436.4 mg na moxifloxacin hydrochloride, wanda yayi daidai da 400 MG na moxifloxacin. Componentsananan abubuwan da aka gyara:

• baƙin ƙarfe oxide,
• hydroxypropyl methylcellulose,
• magnesium stearate,
• MCC
• makarin sodium,
• lactose monohydrate.

An sanya maganin a cikin blisters na 5, 7 ko 10 inji. ko a cikin kwalaben polymer na 100, 500 ko 1000 inji mai kwakwalwa. (don cibiyoyin likita). Akwatin na iya 1an murhun 1, 2 ko kwalbar polima 1.

Pharmacodynamics

Magungunan rigakafin rigakafin ƙwayoyin cuta ne kuma yana da sakamako mai kashe ƙwayoyin cuta.

Gram-korau aerobic microorganisms suna da matsayi daban-daban na hankali game da aikin miyagun ƙwayoyi.

Abubuwan da ke aiki da su suna shafar kwafin kwayar halittar halittar mai lalacewa, ta hanyar bayar da gudummawa ga saurin mutuwa. Gram-tabbatattun aerobes suna da hankali a gareta: Staphylococcus aureus, dysgalactiae Streptococcus, Ciwon ƙwayar cuta, staphylococcus saprophyticus, Streptococcus agalactiae, staphylococcus hominis, Haemophilias parainfluenzae, Enterobacter cloae.

Gram-negative aerobic microorganisms suna da matsayi daban-daban na hankali game da aikin miyagun ƙwayoyi: Porphyromonas asaccharolyticus, Bacteroides ovatus, Porphyromonas asaccharolyticus, Prevotella spp., Mycoplasma pneumonia, Coxiella bumettii.

Matsakaici mai hankali ga ƙwayoyin rigakafi sune: Stenotrophomonas maltophilia, Burkholdera cepacia, Pseudomonas aeruginosa.

Magana game da giciye-jure sauran kwayoyi daga rukunin fluoroquinolones.

Contraindications

Koyarwar ta hana sanya magani a irin waɗannan lokuta:

• ciwon sukari mellitus
• fargaba
• tsananin zawo
• shekara 18 da haihuwa
• hypokalemia mai sarrafa kansa,
• lactation
• ciki

Yakamata a dauki jami'in ƙwayar cuta tare da cututtukan hepatic, cututtukan hypokalemia, cututtukan da ke ɗaukar ciki, tsawan QT tazara, cututtukan cututtukan ƙwayar cuta, haɗe tare da corticosteroids. Bugu da kari, yakamata a tsara maganin tare da taka tsantsan ga marasa lafiya da ke fama da cutar sankara.

Yawan abin sama da ya kamata

Mai haƙuri na iya fuskantar tsafe-tsafe, rawar jiki, zawo, amai, da nutsuwa lokacin amfani da magungunan rigakafi fiye da kima.

Farjin ya ƙunshi tsabtace hanji da kuma amfani da magunguna marasa amfani.

Measuresarin matakan suna alamu ne kuma ya kamata a aiwatar da shi ƙarƙashin kulawa da mai nuna alamar ECG. Maganin maganin rigakafin abu ba ya wanzu.

Hulɗa da ƙwayoyi

Idan aka haɗu da ƙwayoyi, ma'adanai, maganin antacids, multivitamins za su tsananta sha da kuma rage ƙwayar plasma.

Yin amfani da kwayoyin rigakafi tare da sauran quinolones suna haifar da bayyanar bayyanar hotontoto.

Ranitidine yana rage yawan moxifloxacin.

Farashi a cikin kantin magani

Kudin maganin rigakafi yana farawa daga 620 rubles. na allunan 5 a cikin fakitin.

Idan akwai maganin cutar ko rashinsa a cikin kantin magani lokacin sayen, zaku iya ba da fifiko ga ɗayan magungunan masu zuwa:

• Maxiflox
• Alvelon-MF,
• Aquamox
• Dabbatarwa,
• Moksimak,
• Megaflox,
• Moxigram
• Vigamox
• Moxiflo
• Moxystar
• Moxispenser
• Canx Kaya Yanar
• Moxifloxacin hydrochloride,
• Moxifloxacin-Optic,
• Moxifloxacin-Alvogen,
• Moxifur
• Simoflox,
• Ultramox
• Moflaxia,
• Heinemox.

Boris Belyaev (masanin ilimin uro), garin Balakovo

Tsarin rigakafin ƙwayoyin cuta na huɗun rigakafi. Tasirin kusan kashi 100% ne wanda ake iya faɗi. Abubuwan da ke haifar da illa suna da yawa sosai. Ina wajabta shi don hadadden jiyya na cututtukan cututtukan hanji da cututtukan zuciya.

Tatyana Sidorova, shekara 38, garin Dzerzhinsk

Tare da taimakon wannan maganin kashe kwayoyin cuta, na warke daga mycoplasmosis. Jigilar hanyoyin dacewa - sau 1 a rana, babu sauran koma-bayan cutar da kowane alamunta. An cimma wannan sakamako a cikin kwanaki 8-9 na shan maganin.

Kristina Verina, yar shekara 25, birnin Zelenogorsk

A asibitin, an gano ni da wani nau'in kwayar cuta ta kwalara, bayan haka suka sanya ni a asibiti na kwana 10. Lokacin da aka canza shi zuwa aikin kulawa da marasa lafiya, an tsara wannan maganin tare da doxycycline. Ban lura da wasu sakamako masu illa da aka nuna a cikin umarnin ba, babu rashin jin daɗi yayin duk lokacin shan maganin. Yanzu na warke kuma ina jin dadi.

Vera Ignatyeva, ɗan shekara 34, birnin Kalach-on-Don

Lokacin da na ci karo da cystitis, na fara amfani da Aquamox, amma na sami rashin lafiyan ciki. Likita ya maye gurbinsa da plevilox. Jikina a hankali ya dauki wannan magani. An kawar da cutar a cikin makonni 1.5 na gudanar da maganin yau da kullun a cikin allurai da aka nuna.

Haihuwa da lactation

Tsarewar moxifloxacin yayin daukar ciki ba a kafa shi ba.

An bayyana lalata lalacewar haɗin gwiwa a cikin yara da aka bi da su tare da wasu ƙwayoyin rigakafi na quinolone, amma ba a ba da rahoton irin wannan sakamako da haɗuwa da tayin ba. Nazarin dabbobi suna nuna yawan guba.

Yin amfani da moxifloxacin a lokacin daukar ciki yana contraindicated.

Kamar sauran magungunan rigakafi na quinolone, moxifloxacin yana da lahani ga ci gaba da haɓaka ƙwayar guringuntsi a cikin abubuwan da ke tallafawa cikin dabbobi masu haɓaka.

Ana amfani da karamin adadin moxifloxacin a cikin madara. Ba a samun bayanai game da amfani da moxifloxacin a cikin mata yayin shayarwa da ciyarwa.

Yin amfani da moxifloxacin a cikin mata masu shayarwa ya kebanta.

Bayanai na Tsare na Haraji

A cikin nazarin haƙuri a cikin karnuka, babu alamun rashin haƙuri yayin amfani da moxifloxacin cikin ciki. Bayan gudanarwar cikin ciki, an lura da canje-canje na kumburi wanda ya shafi ƙwayar laushi, wanda ke nuna cewa yakamata a guji sarrafawar cikin abubuwan moxifloxacin.

Sashi da gudanarwa

Manya

Kashi na Plevilox 400 MG (1 kwamfutar hannu) sau ɗaya a cikin kowane awa 24. Tsawon lokacin jiyya ya dogara da nau'in kamuwa da cuta, kamar yadda aka bayyana a cikin tebur 1.

Tebur 1: Sashi da tsawon lokacin jiyya a cikin marasa lafiyar

Kashi kowane 24 hours

Tsawon lokaci b (kwana)

Cututtukan ƙwayar cuta na ƙwayar cuta

Maganin ƙwayar cuta na ƙwayar cuta na kullum

Kwayar cuta mara amfani da fata da tsarinta

Cutar da ke tattare da fata da tsarinta

Abun ciki na ciki

wanda ke haifar da rikice-rikice na sama (duba sashin “Alamu don amfani”).

6 Ana iya yin allurar rigakafi (a cikin jijiya sannan kuma a baka) a shawarar likita.

Ana nuna kulawa ta wucin gadi lokacin da wannan hanyar gudanarwa ta kasance mafi dacewa ga mai haƙuri (alal misali, mai haƙuri ba zai iya yin amfani da hanyar maganin). Lokacin canzawa daga gudanarwa na ciki zuwa na baka, ba a buƙatar daidaita sashi. Marasa lafiya waɗanda aka fara jiyya ta hanyar gudanarwar jijiya na moxifloxacin za a iya tura su zuwa allunan gwargwadon alamun asibiti a cikin shawarar likita.

Al'umma na Musamman

A cikin tsofaffi da marasa lafiya da ƙananan nauyin jiki, ba a buƙatar daidaita sashi ba.

Moxifloxacin yana contraindicated a cikin yara da matasa (

Siffofin aikace-aikace

Guba mai guba

Lokacin da ake nazarin tasirin moxifloxacin akan aikin haihuwa a beraye, zomaye da birai, an tabbatar da cewa moxifloxacin yana ƙetare mahaifa. Karatun a cikin berayen (lokacin amfani da moxifloxacin magana da bakin ciki da biji) da birai (lokacin amfani da moxifloxacin a ciki) bai bayyana tasirin teratogenic na moxifloxacin da tasirin sa akan haihuwa. Tare da yin amfani da moxifloxacin a cikin zomaye a kashi 20 na MG / kg, an lura da rashin lafiyar kasusuwan. Waɗannan bayanan suna da alaƙa da sananniyar tasirin quinolones akan ci gaban kwarangwal. An bayyana karuwar adadin ɓarna a cikin birai da zomaye tare da yin amfani da moxifloxacin a sashi na warkewa. A cikin beraye, an sami raguwar nauyin fetal, hauhawar ɓarna, ƙarancin ƙaruwa a cikin lokacin haihuwar da kuma haɓaka cikin ayyukan mara lafiyan zuriyar maza da mata yayin amfani da moxifloxacin, sigar da ya ninka sau 63 sama da shawarar warkewar cutar da aka yiwa mutum.

Tasiri kan iya tuƙin motoci da sauran haɗarihanyoyin

Fluoroquinolones, gami da moxifloxacin, na iya haifar da ƙarancin ikon tuƙa motocin ko wasu ƙwararrun haɗari saboda halayen daga tsarin jijiyoyi na tsakiya.

Kariya da aminci

A wasu halaye, bayan amfani da farko na miyagun ƙwayoyi, rashin lafiyar jiki da halayen rashin lafiyan na iya haɓaka. Da wuya, halayen anaphylactic zai iya ci gaba zuwa barazanar rayuwa mai haɗari anaphylactic, koda bayan amfani da farko na miyagun ƙwayoyi. A cikin waɗannan halayen, moxifloxacin yakamata a daina kuma ana buƙatar matakan kulawa da suka dace (gami da anti-shock).

An ba da rahoton cututtukan hepatitis, na iya haifar da gazawar hanta mai haɗari, gami da mutuwa. Idan alamun gazawar hanta ya bayyana, ya kamata marassa lafiya su nemi likita kai tsaye kafin su ci gaba da magani.

Idan halayen ya faru a wani ɓangaren fata da / ko membranes na mucous, yakamata ku tuntuɓi likita nan da nan kafin ku ci gaba da magani. Amfani da magungunan quinolone yana da alaƙa da yuwuwar haɗarin kamuwa da cuta. Ya kamata a yi amfani da Moxifloxacin tare da taka tsantsan a cikin marasa lafiya da cututtukan cututtukan ƙwayar cuta na tsakiya da kuma yanayin da suke shakku game da shigawar jijiyoyi na tsakiya, yana nuni ga abin da ya faru na ɓacin rai, ko rage ƙwanƙwasa don aiki mai ɗaukar hankali.

Amfani da magungunan kashe ƙwayoyin cuta da ƙwaƙwalwar ƙwayar cuta, ciki har da moxifloxacin, yana haɗuwa da haɗarin haɓakar cututtukan cututtukan cututtukan ƙwayar cuta da ke hade da shan ƙwayoyin rigakafi. Dole ne a kula da wannan cutar a cikin marasa lafiya waɗanda ke fuskantar matsanancin zawo yayin cutar tare da moxifloxacin. A wannan yanayin, yakamata a ba da magani ta dace da gaggawa. Marasa lafiya waɗanda ke da gudawa mai guda biyu an hana su cikin kwayoyi waɗanda ke hana motsin hanji.

Ya kamata a yi amfani da Moxifloxacin tare da taka tsantsan a cikin marasa lafiya da ke fama da cutar Gravis myasthenia gravis, tunda maganin zai iya nuna alamun wannan cutar. A lokacin jiyya tare da fluoroquinolones, gami da moxifloxacin, musamman a cikin tsofaffi marasa lafiya da ke karɓar glucocorticosteroids, tendonitis da ƙwanƙwasa jiji na iya haɓaka. A farkon alamun jin zafi ko kumburi a wurin raunin, yakamata a dakatar da miyagun ƙwayoyi kuma an sami sassauci akan reshen da abin ya shafa.

Ga marasa lafiya da cututtukan ƙwayar cuta mai rikitarwa na gabobin pelvic (alal misali, hade da tubo-ovarian ko ƙashin ƙashin ƙugu) don wanda aka nuna maganin jijiyoyin jiki, amfani da moxifloxacin a cikin allunan 400 mg ba da shawarar ba.

Lokacin amfani da quinolones, ana lura da halayen kulawa. Koyaya, yayin ingantaccen nazari, nazarin asibiti, kazalika da amfani da moxifloxacin a aikace, ba'a lura da halayen daukar hoto ba. Koyaya, marassa lafiya da suke karɓar moxifloxacin yakamata su guji hasken rana kai tsaye da kuma radadin ultraviolet.

Tsawan tazaraQTcda yiwuwar yanayin asibiti

An gano cewa moxifloxacin yana tsawaita tazara ta QTc akan wayoyin wasu marasa lafiya. Yayin nazarin ECGs da aka samu a zaman wani ɓangare na shirin gwaji na asibiti, tsawaita tazara ta QTc lokacin ɗaukar moxifloxacin shine 6 millise seconds ± 26 millise seconds, wanda shine 1.4% idan aka kwatanta da matakin farko. Saboda gaskiyar cewa tsayin tsaka-tsakin tsaka-tsakin tsaka-tsakin QTc a cikin mata ya fi na maza yawa, mata na iya zama mai saurin kamuwa da aikin kwayoyi masu tsawaita QTc. Tsofaffi mutane kuma sun fi saurin kamuwa da cutar ta hanyar kantin QT.

Matsakaicin tsawan tsakaitaccen tsaka-tsakin QT na iya ƙaruwa tare da kara yawan ƙwayoyi, don haka shawarar da aka ba da shawarar kada ta wuce. Tsawaita tazara na QT yana da alaƙa da haɓakar haɗarin arrhythmias, ciki har da polymorphic ventricular tachycardia. Koyaya, a cikin marasa lafiya da ciwon huhu babu wata dangantaka tsakanin maida hankali ga moxifloxacin a cikin jini da kuma tsawaita tazara ta QT. Babu ɗayan 9,000 marasa lafiya da aka bi da moxifloxacin da ke fama da rikice-rikice na zuciya da mutuwar da ke da alaƙa da tsawaita QT. Koyaya, a cikin marasa lafiya waɗanda ke da alaƙa game da arrhythmias, yin amfani da moxifloxacin na iya ƙara haɗarin arrhythmias ventricular.

A wannan batun, ya kamata a guji kula da moxifloxacin a cikin marasa lafiya tare da tsawan QT na tsaka-tsaki, hypokalemia marasa daidaituwa, kamar yadda kuma a cikin waɗanda suke karɓar magungunan IA antiarrhythmic kwayoyi (quinidine, procainamide) ko aji III (amiodarone, sotalol), tun da kwarewar amfani da moxifloxacin a cikin waɗannan marasa lafiya. na halitta. Ya kamata a tsara moxifloxacin tare da taka tsantsan, tun da ƙari sakamakon moxifloxacin ba za'a iya cire shi a cikin halaye masu zuwa:

a cikin marasa lafiya da ke karɓar magani tare da kwayoyi masu haɓaka tsaka-tsakin QT (cisapride, erythromycin, magungunan antipsychotic, maganin tricyclic antidepressants),

a cikin marasa lafiya da ke cikin yanayin yanayin da ake magana a kai na farhythmias, kamar muhimmin ƙwayar bradycardia, mchemicial ischemia,

a cikin marasa lafiya da kewaya, tunda kasancewar fadada tazara ta Qt a cikinsu ba za a iya cire su ba,

a cikin mata ko tsofaffi marasa lafiya waɗanda zasu iya zama masu hankali ga magungunan da ke tsawaita lokacin QT,

Idan alamun cututtukan zuciya ke faruwa yayin jiyya tare da moxifloxacin, ya kamata ku daina shan magungunan kuma kuyi ECG.

Miyagun ƙwayoyi Plevilox: umarnin don amfani

Magungunan rigakafin ƙwayar cuta Plevilox yana ba ka damar yin gwagwarmaya tare da cututtuka da yawa, wakilai na abubuwanda ke haifar da ƙananan ƙwayoyin cuta a aikinta. Koyaya, miyagun ƙwayoyi yakamata a tsara shi kawai, saboda magani na kai na iya haifar da sakamako wanda ba a tsammani.

Plevilox yana ba ku damar yaƙi da cututtukan da yawa, abubuwan da ke haifar da abin da ƙananan ƙwayoyin cuta ke kula da aikinta.

14 Analogs

Idan akwai maganin cutar ko rashinsa a cikin kantin magani lokacin sayen, zaku iya ba da fifiko ga ɗayan magungunan masu zuwa:

• Maxiflox
• Alvelon-MF,
• Aquamox
• Dabbatarwa,
• Moksimak,
• Megaflox,
• Moxigram
• Vigamox
• Moxiflo
• Moxystar
• Moxispenser
• Canx Kaya Yanar
• Moxifloxacin hydrochloride,
• Moxifloxacin-Optic,
• Moxifloxacin-Alvogen,
• Moxifur
• Simoflox,
• Ultramox
• Moflaxia,
• Heinemox.

Boris Belyaev (masanin ilimin uro), garin Balakovo

Tsarin rigakafin ƙwayoyin cuta na huɗun rigakafi. Tasirin kusan kashi 100% ne wanda ake iya faɗi. Abubuwan da ke haifar da illa suna da yawa sosai. Ina wajabta shi don hadadden jiyya na cututtukan cututtukan hanji da cututtukan zuciya.

Tatyana Sidorova, shekara 38, garin Dzerzhinsk

Tare da taimakon wannan maganin kashe kwayoyin cuta, na warke daga mycoplasmosis. Jigilar hanyoyin dacewa - sau 1 a rana, babu sauran koma-bayan cutar da kowane alamunta. An cimma wannan sakamako a cikin kwanaki 8-9 na shan maganin.

Kristina Verina, yar shekara 25, birnin Zelenogorsk

A asibitin, an gano ni da wani nau'in kwayar cuta ta kwalara, bayan haka suka sanya ni a asibiti na kwana 10. Lokacin da aka canza shi zuwa aikin kulawa da marasa lafiya, an tsara wannan maganin tare da doxycycline. Ban lura da wasu sakamako masu illa da aka nuna a cikin umarnin ba, babu rashin jin daɗi yayin duk lokacin shan maganin. Yanzu na warke kuma ina jin dadi.

Vera Ignatyeva, ɗan shekara 34, birnin Kalach-on-Don

Lokacin da na ci karo da cystitis, na fara amfani da Aquamox, amma na sami rashin lafiyan ciki. Likita ya maye gurbinsa da plevilox. Jikina a hankali ya dauki wannan magani. An kawar da cutar a cikin makonni 1.5 na gudanar da maganin yau da kullun a cikin allurai da aka nuna.

Angelina Marinina, 'yar shekaru 44, garin Vladimir

An magance ta tare da wadannan kwayoyin cutar don ciwon huhu. Wani ingantaccen maganin rigakafi wanda ke taimakawa da sauri. Koyaya, bayan amfani da maganin, sai na yi burushi. Likitan ya ce wannan ya zama ruwan dare. Dole ne in bugu da drinkari in sha Diflucan.

Siffar saki na Plevilox

400 MG allunan da aka saka a fim, bliri 5 fakitin kwali 1,

400 MG allunan da aka saka a fim, blris 7 fakitin kwali 1,

400 MG allunan da aka saka a fim, blris 10 fakitin kwali 1,

400 MG allunan da aka saka a fim, blris 7 fakitin kwali 2,

400 MG allunan da aka saka fim, bliri 10 fakitin kwali 2,

Kwayoyin kwayoyi masu nauyin 400 MG, jakar polyethylene (sachet) 100 Can (kwalba) polymer 1,
Kwayoyin kwayoyi masu nauyin 400 MG, jakar filastik (jakar) 500 Can (jar) polymer 1,
400 MG allunan da aka rufe fim, jakar filastik (jakar) 1000 can (jar) polymer 1,

Kasuwancin ATX:

J Antimicrobials don amfani da tsari

J01 Magungunan antimicrobial don amfani na yau da kullun

JB1M Antibacterials - Kalaman quinolone

Ana amfani da bayanin don maganin Plevilox da aka jera akan wannan shafin yanar gizon mu don amfanin yau da kullun.

Yawan shan magani

Bayyanar cututtuka: mai yiwuwa raguwa cikin aiki, nutsuwa, amai, gudawa, zazzage jiki gaba ɗaya, raɗaɗi. Jiyya: Lavage na ciki (a cikin sa'o'i biyu na farko bayan an wuce gona da iri), kallo, magani na alama tare da saka idanu na ECG. Babu takamaiman maganin rigakafi .. Yana da mahimmanci don tabbatar da isasshen ƙwayar ƙwayar cikin jiki yayin kiyaye isasshen diuresis.

Shawara ta musamman don amfani da miyagun ƙwayoyi

Don rage haɗarin haɓaka jigilar moxifloxacin kuma don kiyaye tasirin ƙwayoyin ƙwayoyin cuta, moxifloxacin ya kamata a wajabta kawai don maganin cututtukan cututtukan da ke haifar da damuwa ta wannan ƙwayar. A lokacin jiyya, ECG saka idanu wajibi ne (tsawaita ta tazara ta QT, ƙwaƙwalwar ventricular arrhythmias). Matsakaicin tsawan tsakaitaccen tsaka-tsakin QT na iya ƙaruwa tare da kara yawan ƙwayoyi, don haka shawarar da aka ba da shawarar kada ta wuce. Tsawaita tazara na QT yana da alaƙa da haɓakar haɗarin arrhythmias, wanda ya hada da fighter-flutter. A lokacin jiyya tare da fluoroquinolones, gami da moxifloxacin, musamman a cikin tsofaffi marasa lafiya da ke karɓar glucocorticosteroids, haɓakar tendonitis da rushewar jijiya mai yiwuwa. A farkon alamun jin zafi ko kumburi a wurin raunin, yakamata a dakatar da miyagun ƙwayoyi kuma an sami sassauci akan reshen da abin ya shafa. Game da cutar zazzabin cizon sauro yayin magani tare da moxifloxacin, yakamata a dakatar da miyagun ƙwayoyi kuma an tsara maganin da ya dace. A wasu halayen, halayen rashin lafiyan cuta na iya haɓakawa, gami da barazanar kamuwa da ƙwayar cuta na rayuwa. A cikin waɗannan halayen, moxifloxacin ya kamata a daina aiki kuma ya zama dole (gami da maganin antishock) yakamata a tsara: glucocorticosteroids, norepinephrine, antihistamines. Moxifloxacin bashi da kaddarorin kariya. Koyaya, marassa lafiya da suke karɓar moxifloxacin yakamata su guji hasken rana kai tsaye da kuma radadin ultraviolet. Duk da gaskiyar cewa moxifloxacin da wuya ya haifar da mummunan sakamako daga tsarin juyayi na tsakiya, marasa lafiya yakamata su san halayen su ga miyagun ƙwayoyi kafin su tuka mota / kayan motsawa.