Insulin Apidra Solostar: umarnin don amfani

Abunda yake aiki: insulin glulisin - 100 PIECES (3.49 mg),
tsofaffi: metacresol (m-cresol) 3.15 mg, trometamol (tromethamine) 6.0 mg, sodium chloride 5.0 mg, polysorbate 20 0.01 mg, sodium hydroxide zuwa pH 7.3, hydrochloric acid zuwa pH 7 3, ruwa don yin allura har zuwa 1.0 ml.

Bayanin M ruwa mai ruwa mara launi.

Propertiesungiyoyin magunguna:

Pharmacodynamics Insulin glulisin wani abu ne wanda yake cike da insulin na mutum, wanda yake daidai da karfin insulin na mutane.
Babban mahimmancin aikin insulin da analogues na insulin, gami da insulin glulisin, shine ƙa'idar aiki na glucose. Insulin yana rage yawan glucose a cikin jini, yana karfafa shaye-shayen glucose ta kasusuwa na waje, musamman tsokoki na kasusuwa da tsotse nama, da kuma hana samuwar glucose a cikin hanta. Insulin yana hana lipolysis a cikin adipocytes, yana hana proteolysis kuma yana haɓaka haɗarin furotin. Nazarin a cikin masu ba da agaji da lafiya da marasa lafiya tare da masu ciwon sukari mellitus sun nuna cewa tare da subcutaneous management na insulin, glulisin yana fara aiki da sauri kuma yana da ɗan gajeren lokacin aiki fiye da insulin ɗan adam mai narkewa. Tare da gudanarwa na subcutaneous, sakamakon insulin glulisin, wanda ke rage yawan glucose a cikin jini, yana farawa bayan minti 10-20. Lokacin da aka gudanar da shi ta hanyar ciki, sakamakon rage rage yawan glucose a cikin jinin insulin glulisin da insulin ɗan adam ya yi daidai da ƙarfi. Unitaya daga cikin yanki na insulin glulisin yana da aiki iri ɗaya na aikin hypoglycemic kamar yanki ɗaya na insulin ɗan adam mai narkewa.
A cikin lokaci na gwaji na asibiti a cikin marasa lafiya da ke da nau'in ciwon sukari na 1 na sukari, ana amfani da bayanan inspolylymic na insulin glulisin da insulin ɗan adam mai narkewa a cikin kashi 0.15 U / kg a lokuta daban-daban dangane da daidaitaccen abinci na mintina 15. Sakamakon binciken ya nuna cewa glulisin insulin, wanda aka gudanar da mintina 2 kafin cin abinci, ya samar da sarrafawar glycemic iri daya bayan cin abinci kamar yadda insulin dan adam mai narkewa, ana gudanar da mintina 30 kafin cin abinci. Lokacin da aka gudanar da mintina 2 kafin cin abinci, insulin glulisin ya samar da mafi kyawun sarrafa glycemic bayan cin abinci fiye da insulin ɗan adam mai narkewa 2 mintuna kafin cin abinci. Glulisin insulin, ana gudanar da shi na mintina 15 bayan fara cin abinci, ya samar da maganin glycemic iri iri bayan cin abinci kamar insulin mutum, ana ba shi minti 2 kafin cin abinci.
Wani rukuni da na yi nazari tare da insulin glulisin, insulin lispro da insulin mutum a cikin rukuni na marasa lafiya da ke fama da ciwon sukari da kuma kiba sun nuna cewa a cikin wadannan marasa lafiya insulin glulisin yana rike sifofin sa da sauri. A cikin wannan binciken, lokacin da ya isa zuwa 20% na jimlar AUC (yanki a ƙarƙashin ɓoye lokaci-lokaci) minti 114 ne don insulin glulisin, minti 121 na insulin lispro da minti 150 don insulin ɗan adam mai narkewa, da AUC (0-2 hours), yana nuna Hakanan farkon aikin hypoglycemic, bi da bi, shine 427 mg / kg don glulisin insulin, 354 mg / kg don lispro insulin, da 197 mg / kg don insulin ɗan adam mai narkewa.
Nazarin asibiti na 1.
A cikin gwajin asibiti na 26-mako na kashi III, wanda ya kwatanta insulin glulisin tare da insulin lispro, ana gudanar da subcutaneously jim kaɗan kafin abinci (minti 0¬15), marasa lafiya waɗanda ke da nau'in ciwon sukari na 1 na mellitus ta amfani da gulingine insulin kamar basal, insulin glulisin ya kasance kwatankwacin insulin lispro dangane da sarrafawar glycemic, wanda aka kimanta shi da canjin da aka samu a cikin gemocosylated haemoglobin (Lb1c) a lokacin binciken binciken idan aka kwatanta shi da na farkon. Kwatanta darajar glucose na jini an lura, ta hanyar kulawa da hankali. Tare da gudanar da insulin glulisin, ya bambanta da magani tare da insulin, lyspro bai buƙatar haɓaka kashi na insulin basal ba.
Gwajin asibiti na 12-mako na III wanda aka gudanar a cikin marasa lafiya da ke da nau'in ciwon sukari na 1 wanda ya karbi insulin glargine a matsayin maganin basal ya nuna cewa ingancin aikin insulin glulisin nan da nan bayan abinci ya kasance daidai da na insulin glulisin nan da nan kafin abinci (na Minti 0-15) ko insulin ɗan adam mai narkewa (minti 30-45 kafin abinci).
A cikin yawan marasa lafiyar da suka kammala yarjejeniya na binciken, a cikin rukuni na marasa lafiya waɗanda suka karbi glulisin insulin kafin abinci, an lura da raguwa mai yawa a cikin HL1C idan aka kwatanta da rukuni na marasa lafiya waɗanda suka sami insulin ɗan adam mai narkewa.

Type 2 ciwon sukari
An gudanar da gwajin asibiti na 26-mako na III wanda ya biyo bayan nazarin aminci na mako-mako 26 don kwatanta insulin glulisin (mintuna 0-15 kafin abinci) tare da insulin ɗan adam mai narkewa (minti 30-45 kafin abinci), wanda An gudanar da subcutaneously a cikin marasa lafiya tare da nau'in ciwon sukari na 2 na mellitus, ban da amfani da insulin-isofan a matsayin insalin basal. Matsakaicin matsakaiciyar jikin mutum mai haƙuri shine 34.55 kg / m2. Insulin glulisin ya nuna kansa yayi daidai da insulin ɗan adam mai narkewa dangane da canje-canje a cikin ƙwaƙwalwar HL1C bayan watanni 6 na magani idan aka kwatanta da ƙimar farko (-0.46% don glulisin insulin da -0.30% don insulin ɗan adam mai narkewa, p = 0.0029) bayan watanni 12 na magani idan aka kwatanta da darajar farko (-0.23% don glulisin insulin da -0.13% don insulin ɗan adam mai narkewa, bambanci ba shi da mahimmanci). A cikin wannan binciken, yawancin marasa lafiya (79%) sun gauraye insulin gajere da aiki tare da insulin-isophan nan da nan kafin allurar. Ma'aikatan 58 a lokacin bazuwar sun yi amfani da wakilan maganin hypoglycemic na baki da karɓar umarni don ci gaba da shan su a cikin guda ɗaya (sigar canzawa).

Nasihu da jinsi
A cikin gwajin asibiti da aka sarrafa a cikin manya, bambance-bambance a cikin aminci da inganci na insulin glulisin ba a nuna su ba a cikin binciken ƙananan ƙungiyoyi da aka rarrabe ta jinsi da jinsi.

Pharmacokinetics A cikin insulin glulisin, maye gurbin amino acid asparagine na ɗan adam insulin a matsayin B3 tare da lysine da lysine a matsayi B29 tare da acid glutamic yana haɓaka ɗaukar sauri.

Kasancewa da Bioavailability
Lokaci na maida hankali akan Pharmacokinetic a cikin masu sa kai masu lafiya da marasa lafiya da ke da nau'in 1 da nau'in ciwon sukari guda 2 wanda ya nuna cewa yawan ƙwayar insulin glulisin idan aka kwatanta da insulin ɗan adam mai narkewa shine kusan sau 2 cikin sauri, kuma mafi girman yawan ƙwayar plasma da aka samu (Stax) ya kusan 2 sau more.
A cikin binciken da aka gudanar a cikin marasa lafiya da nau'in ciwon sukari na 1 na mellitus, bayan subcutaneous na gudanar da insulin glulisin a cikin kashi 0.15 U / kg, Tmax (lokacin farawa mafi yawan ƙwayar plasma) minti 55 ne, kuma Stm ya kasance 82 ± 1.3 mcU / ml idan aka kwatanta da Tmax na mintina 82 da Cmax na 46 ± 1.3 μU / ml don maganin insulin na mutum. Lokacin zama a cikin tsari na yaduwar insulin glulisin ya yi guntu (minti 98) fiye da na insulin dan adam mai narkewa (minti 161).
A cikin binciken a cikin marasa lafiya da nau'in ciwon sukari na 2 na mellitus bayan subcutaneous management na insulin glulisin a cikin kashi na 0.2 PIECES / kg, Stax ya kasance 91 mcU / ml tare da latti na tsakiyar 78 zuwa 104 mcU / ml.
Tare da subcutaneous management na insulin glulisin a cikin yankin na gaban bango na ciki, cinya, ko kafada (a cikin deltoid tsoka yankin), sha da sauri lokacin da aka gabatar da shi a cikin yankin na bangon ciki na ciki kamar yadda idan aka kwatanta da gudanar da miyagun ƙwayoyi a cikin yankin na cinya. Yawan sha daga yankin da aka kera ya kasance tsaka-tsaki.
Cikakken bioavailability na insulin glulisin bayan gudanarwar subcutaneous shine kusan 70% (73% daga bangon ciki na ciki, 71 daga ƙwayar tsoka da 68% daga yankin femasin) kuma yana da ƙananan bambanci a cikin marasa lafiya daban-daban.

Rarraba
Rarraba da kewayon insulin glulisin da mai narkewa na mutum bayan gudanarwar jijiyoyin jini iri daya ne, tare da yawan rarraba lita 13 da lita 21 da rabin rayuwar mintuna 13 da 17 bi da bi.

Kiwo
Bayan subulinaneous management na insulin, glulisin ya keɓewa da sauri fiye da insulin ɗan adam mai narkewa, yana da rabin rabin rayuwa na minti 42, idan aka kwatanta da rabin rayuwar insulin ɗan adam mai minti 86. A cikin binciken giciye-bincike na insulin glulisin cikin duka mutane masu lafiya da wadanda ke da nau'in 1 da nau'in ciwon sukari na 2, bayyanar rabin rabin rayuwar daga mintuna 37 zuwa 75.

Rukunin Masu haƙuri na Musamman

Marasa lafiya tare da gazawar koda
A cikin binciken asibiti da aka gudanar a cikin mutane ba tare da dumbin yanayin aikin kodan ba (keɓantar creatinine (CC)> 80 ml / min, 30¬50 ml / min, 1/10, gama:> 1/100, 1/1000, 1 / 10000, A kan sigar da nau'in sakin

Don haka, Apidra insulin ne mai gajeren zango. Daga matsayin duba yanayin hada-hadar kudi - wannan shine mafita. An yi niyya don keɓaɓɓen ƙwaƙwalwar ƙasa kuma ya zama cikakke, har da mara launi (a wasu lokuta, ɗan ƙaramin inuwa har yanzu yana nan).

Babban ɓangarensa, wanda yake a cikin ƙaramin rabo a cikin, ya kamata a yi la’akari da insulin da ake kira glyzulin, wanda yanayinsa da saurin aiki da sakamako mai dorewa. Wadanda suka ware sune:

cresol
daikin,
sinadarin sodium
polysorbate da yawa wasu, ana samun su a.

Dukkansu sun haɗu tare suna samar da tsari ba tare da wataƙila wani magani na musamman da za'a iya samu tare da kowane nau'in ciwon sukari ba: na farko da na biyu. Ana samar da insulin na Apidra a cikin nau'i na katako na musamman waɗanda aka yi da gilashin launi.

Game da tasirin magunguna

Yaya Apidra ke shafan glucose?

Glulin insulin shine farfadowar hormone mutum. Kamar yadda kuka sani, yana iya zama da kwatankwacin ƙarfi don narkewar insulin na ɗan adam, amma halayyar ce ta fara "aiki" da sauri kuma yana da ɗan gajeren lokaci na fallasa. wannan ya fi amfani.

Mafi mahimmancin gaske da tasiri na yau da kullun ba wai kawai ga insulin ba, har ma da analogues dinsa, ya kamata a yi la'akari da kullun ka'idoji dangane da canzawar glucose. Hoton da aka gabatar yana rage yawan sukari a cikin jini, wanda ke karfafa yin amfani da glucose tare da taimakon tsokoki na waje, kamar yadda tare da. Wannan gaskiyane musamman ga tsokawar kasusuwa da tsoka nama. Har ila yau, insulin na Apidra yana hana samuwar glucose a cikin hanta. Bugu da kari, yana katse dukkanin hanyoyin da suka danganci lipolysis a cikin adipocytes, kariya da kuma haɓaka hulɗa da furotin.

Dangane da sakamakon binciken da yawa, an tabbatar da cewa glulisin, kasancewa shine babban bangaren kuma ana gabatar dashi minti biyu kafin cin abinci, zai iya samar da iko iri ɗaya na adadin glucose bayan cin abinci kamar irin insulin ɗan adam wanda ya dace da rushewa. Koyaya, yakamata a gudanar dashi minti 30 kafin cin abinci.

Game da sashi

Mafi mahimmancin batun aiwatar da kowane irin magani, gami da maganin insulin, yakamata a yi la'akari da bayyanar sashi. Ana ba da shawarar Apidra da za a gabatar da shi jim kaɗan (don ƙarancin sifili da matsakaicin mintina 15) kafin ko nan da nan bayan cin abinci.

Za'a iya amfani da miyagun ƙwayoyi a haɗe tare da takamaiman nau'ikan nau'ikan cututtukan jini.

Yadda za a zabi kashi na Apidra?

Ya kamata a zaɓi allurar insulin dosing algorithm daban-daban kowane lokaci. A cikin taron cewa ana gano gazawar renal, raguwa a cikin buƙatar wannan hormone yana yiwuwa.

A cikin masu ciwon sukari tare da nakasa aiki na wannan sashin jiki kamar hanta, buƙatar samar da insulin ya fi ƙarfin ragewa. Wannan ya faru ne saboda rage karfin glucose neogenesis da raguwar metabolism dangane da insulin. Duk wannan yana bayyana ma'anar bayyananne kuma, ba ƙaramin mahimmanci ba, biye da maganin da aka nuna, yana da matukar muhimmanci a lura da ciwon sukari.

Game da allura

Dole ne a gudanar da maganin ta hanyar allurar subcutaneous, kazalika da ci gaba da jiko. An bada shawarar yin wannan na musamman a cikin kasusuwa da ƙoshin kitse ta amfani da tsarin aikin famfo na musamman.

Dole ne a aiwatar da injections na Subcutaneous in:

Ya kamata a gabatar da insulin na Apidra ta amfani da jinkirin jiko a cikin kashi mai ƙwaya ko mara mai kyau a cikin ciki. Bangarorin ba wai kawai allura ba ne, har ma da abubuwan da aka samar a bangarorin da aka gabatar, kwararru sun bada shawarar musayar junan su don kowane sabon tsarin na bangaren. Irin waɗannan abubuwan kamar yankin dasawa, aikin jiki, da sauran yanayin "iyo" na iya samun tasiri akan girman hanzarin ɗaukar ciki kuma, sakamakon hakan, a kan ƙaddamar da girman tasirin.

Yaya za a bayar da allura?

Shiga ciki daga ciki zuwa bangon yankin na ciki ya zama garanti na mafi yawan hanzarin jan ciki fiye da shigar cikin wasu sassan jikin mutum. Tabbatar ka bi ka'idodin ka'idodi don kauda abubuwan ci gaba na miyagun ƙwayoyi a cikin tasoshin jini na nau'in jini.

Bayan gabatarwar insulin "Apidra" an hana shi tausa wurin allurar. Hakanan ya kamata a koyar da masu ciwon sukari kan madaidaicin dabarar allurar. Wannan zai zama mabuɗin hanyar ingantaccen magani 100%.

Game da yanayin ajiya da sharuɗɗa

Don iyakar sakamako a cikin aiwatar da amfani da kowane ɓangaren magani, wanda ya isa ya tuna da yanayin da rayuwar shiryayye. Don haka, katako da tsarin nau'ikan wannan nau'in dole ne a adana su a wuri mai sauƙi ga yara, wanda ya kamata kuma ya kasance yana nuna mahimmancin kariya daga haske.

A wannan yanayin, dole ne a lura da tsarin zafin jiki, wanda ya kamata ya kasance daga digiri biyu zuwa takwas.

Dole ne a sanya kayan sakin jiki mai sanyi.

Bayan da aka fara amfani da tsarin katako da tsarin kayan katako, suna kuma buƙatar a ajiye su a wani wuri da ba a iya zuwa ga yara, suna da amintaccen kariya ba wai kawai daga shigawar haske ba, har ma daga hasken rana. A lokaci guda, alamu na zazzabi kada su wuce digiri 25 na zafi, in ba haka ba wannan na iya fadawa kan ingancin insulin na Apidra.

Don ƙarin tabbataccen kariya daga tasirin haske, ya zama dole don adana ba katako, kawai masana suna ba da shawarar irin waɗannan tsarin a cikin fakitin nasu, wanda aka yi da kwali na musamman. Rayuwar shiryayye daga kayan da aka bayyana shine shekara biyu.

Duk game da ranar karewa

Rayuwar shiryayye na ƙwayar cuta wanda ke cikin kicin ko wannan tsarin bayan amfani na farko shine makonni huɗu. Yana da kyau a tuna cewa lambar da aka ɗauki farkon insulin ɗin ta yi alama akan kunshin. Wannan zai zama ƙarin garantin don nasarar ci gaban kowane nau'in ciwon sukari.

Game da sakamako masu illa

Ya kamata a lura da tasirin gefen da ke rarrabe insulin insulin. Da farko dai, muna magana ne game da irin wannan abu a matsayin hypoglycemia. An kirkiro shi ne saboda yawan amfani da insulin mai yawa, watau, wadanda suka zama sun fi ainihin bukatar hakan.

A wani ɓangaren irin wannan ƙwayar ƙwayar ƙwayar cuta kamar yadda metabolism yake, hypoglycemia shima yana daɗaɗɗa. Duk alamun bayyanar sa an san shi kwatsam: akwai gurnani mai sanyi, rawar jiki da ƙari. Hadarin a cikin wannan yanayin shine hypoglycemia zai karu, kuma wannan na iya haifar da mutuwar mutum.

Hakanan halayen gida zasu iya yiwuwa, waxanda sune:

hyperemia,
puff,
gagarumar itching (a wurin allura).

Wataƙila, ban da wannan, haɓakar halayen rashin lafiyan yanayi, a wasu yanayi muna magana ne game da cutar urticaria ko rashin lafiyar mahaifa. Koyaya, wasu lokuta wannan ba yayi kama da matsalolin fata ba, amma kawai cire kaya ko wasu alamu na zahiri. A kowane hali, duk cututtukan da aka gabatar ba shakka babu za a iya kauce musu ta bin shawarwarin da tuna daidai da amfani da insulin kamar Apidra.

Game da contraindications

Ya kamata a ba da kulawa ta musamman don kowane ƙwayoyi don kulawa ta musamman. Wannan zai zama mabuɗin gaskiyar cewa insulin zai yi aiki a 100%, kasancewa ingantacciyar hanyar ingantacciyar hanyar dawo da kuma kare lafiyar jiki. Don haka, contraindications da ke hana yin amfani da "Apidra" ya kamata ya haɗa da hypoglycemia barga da haɓaka digiri na hankali zuwa insulin, gluzilin, da duk wani ɓangaren magunguna.

Shin mata masu ciki zasu iya amfani da Apidra?

Tare da kulawa ta musamman, yin amfani da wannan kayan aikin ya zama dole ga waɗannan matan waɗanda suke kowane mataki na ciki ko shayarwa. Tunda nau'in insulin da aka gabatar shine magani ne mai ƙarfi sosai, yana iya haifar da wata illa ba ga mace kaɗai ba, har ma ga tayin. Koyaya, wannan tabbas yana da nisa daga duk lamurran da suka danganci ciwon sukari. A wannan haɗin, an ba da shawarar cewa ku fara tuntuɓar ƙwararrun likita wanda zai nuna halatta amfani da insulin “Apidra”, ya kuma tsara gwargwadon ƙwayar da ake so.

Game da alamomi na musamman

A yayin aiwatar da amfani da kowane irin ƙwayoyi, ya zama dole a yi la’akari da mahimman adadin halayen da suke bambanta sosai. Misali, canjin mai cutar sikari zuwa sabon nau'in insulin ko wani abu daga wata damuwa yakamata a gudanar dashi karkashin kulawa ta musamman. Wannan ya faru ne saboda gaskiyar cewa za'a iya buƙatar gaggawa don daidaitawa da ilimin gabaɗaya.

Amfani da rashin isasshen magungunan sashi ko dakatar da magani, musamman a cikin mutanen da ke fama da nau'in ciwon sukari na 1, zai iya haifar da haifar da hyperglycemia ba kawai ba, har ma takamaiman ketoacidosis. Waɗannan halaye ne waɗanda a haɗarin gaske ga rayuwar ɗan adam.

Daidaitawar alluran insulin na iya zama dole idan akwai wani sauyi a cikin tsarin aikin cikin shirin motar ko lokacin cin abinci.

Labarin yana taimaka sosai. Ina tsammanin mutane da yawa waɗanda ke fama da wannan cutar za su taimaka. Na gode da cikakken bayanin yadda ake adana wannan magani. Likita da kansa ya kuma wajabta shi. An rubuta labarin da yawa mai kyau, Ina fata kuma zai taimake ni!

Abunda ke aiki na Apidra shine insulin glulisin. Misalin insulin ne, wanda ake samarwa a jikin dan Adam, amma kwayoyin suna canzawa ta hanyar sake canzawa. Actionarfin aikin abu yana daidai da insulin ɗan adam (mai narkewa), amma, ba kamar ɗayan na ƙarshe ba, aikin yana faruwa da sauri, tsawon lokacin tasirin insulin glulisin ya yi guntu.

Abubuwan da ke aiki suna daidaita musayar kwayoyin glucose, rage mayar da hankali a cikin jini, haɓaka haɗarin ƙwayoyin glucose ta sel a cikin kyallen a kan mahaɗin (musamman tsoka mai kasusuwa, ƙwayoyin mai). Insulin glulisin yana hana samarda glucose a cikin hanta. Apidra yana hana ayyukan lipolysis a cikin ƙwayoyin tsopose nama, yana dakatar da lalata abubuwan gina jiki, da haɓaka hanyoyin haɓaka aikin samar da furotin.

Lokacin gudanar da aikin karkashin kasa, ana lura da rage yawan matakan glucose a cikin sa'o'i 1 / 6-1 / 3. A karkashin yanayin gudanarwar jijiya, ƙarfin insulin glulisin ya yi daidai da ƙarfin insulin ɗan adam. 1 na insulin glulisin yana daidai da naúrar 1 na insulin ɗan adam.

A lokacin gwaji na asibiti, an gano cewa gudanar da Apidra 120 seconds kafin wani yanki na abinci ya ba ku damar sarrafa abubuwan glucose a cikin jini bayan ƙarshen abinci. Ayyukan wannan magani yana baka damar sarrafa mafi kyawun matakin glucose fiye da gabatarwar insulin ɗan adam na ½ awa kafin cin abinci. Abinda ya biyo bayan gudanarwar Apidra ta hanyar ¼ bayan farawar abinci ya dace da aikin insulin na mutum, wanda aka gabatar dashi a jikin mutum 120 seconds kafin cin abinci.

A cikin lura da kiba, bincike na aikin Apidra ya nuna cewa lokacin haɓaka tasirin sakamako a cikin aiki mai aiki yana ɗaukar mintuna 114. AUC na 0-2 hours shine 427 mg × kg.

Hanyar aikace-aikace

Dole ne a aiwatar da gabatarwar Apidra nan da nan kafin abinci ko aƙalla na mintina 15 kafin shi. Ana amfani da miyagun ƙwayoyi a tsarin kulawa wanda ya riga ya ƙunshi shirye-shiryen insulin tare da matsakaicin tsawon lokacin aiki ko analogues na magungunan insulin-mai ɗaukar aiki. Za a iya haɗuwa da Apidra a cikin magungunan warkewa tare da magungunan hypoglycemic don gudanar da maganin baka. An zabi sashi na miyagun ƙwayoyi a kowane yanayi daban-daban.

Wajibi ne a ware gwargwadon yiwuwar miyagun ƙwayoyi shiga gadon jijiyoyin jiki. Hakanan, baza ku iya tausa yankin da aka allurar da maganin ba. Honeyan zuma dole ne ma’aikatan su koyar da mara lafiyar yadda ake sarrafa maganin.

Ba za a yarda a haɗar da Apidra tare da sauran wakilai na warkewa ba (ban da isofan-insulin ɗan adam). Lokacin amfani da magungunan Apidra, wanda aka kawo tare da na'urar famfo, ba a yarda da haɗar da maganin tare da wasu magunguna ba.

Dokoki don amfani da miyagun ƙwayoyi

Kar a sake dakatar da maganin.
Idan ya zama dole a haɗu da maganin Apidra tare da isofan-insulin, to insulin glulisin bayani an fara zana shi cikin sirinji. Kada a ajiye sakamakon cakuda shi.

Kwantena tare da bayani sun dace da alkalan sirinji na OptiPen Pro 1.
Kafin amfani, yakamata ku kimanta mafita a cikin katun don launi (yakamata a bayyana), saboda rashi ƙirar injiniyoyi.
Barin katun a ɗakin zazzabi na mintuna 60-120 kafin saka shi cikin alkalami mai iya sake amfani da shi.
Cire kumfa daga cikin kicin.
Ba a sake amfani da katako ba.
Kada a yi amfani da alkalan da aka lalata.
Ana iya amfani da sirinji na filastik don gudanar da maganin. Don wannan, an cire mafita daga kicin tare da sirinji. Ya kamata a sa masa sirinji don insulin 100 IU / ml.
Ana iya amfani da azaman sirinji mai sake amfani dashi don gudanar da maganin a cikin masu haƙuri ɗaya kawai.

Yin amfani da katako na tsarin OptiClick (wannan katako ne mai dauke da 3 ml na maganin Apidra, wanda aka saka a cikin kwandon filastik sanye da piston):

Wannan tsarin kifin tare da akwati da piston ya kamata a yi amfani dashi da alƙalami mai siki na OptiClick.
An ba da umarnin yin amfani da alkalami na OptiClick syringe a cikin bayanin wannan na'urar.
Idan ya sami matsala na alkairin syringe, ba za a iya amfani da shi ba.
Binciki tsarin katun kafin amfani da mafita. Yakamata babu barbashi na inji a cikin shiri, mafita yakamata a bayyana, ba tare da canza launi ba.
Cire kumfa daga kicin kafin aiwatar da mafita.
Ba za ku iya sake amfani da katun ta cika shi ba.
Daga katun, zaku iya zana maganin a cikin sirinji filastik kuma ku sarrafa magunguna.
Don hana kamuwa da cuta, ba za a yarda a yi amfani da maɓallin sirinji don marasa lafiya da yawa ba.

Gabatar da miyagun ƙwayoyi ana amfani da shi ta hanyar jera allurar subcutaneous. Kuna iya aiwatar da mafita na Apidra a cikin hanyar ci gaba da jiko ta amfani da tsarin famfo. An gabatar da gabatarwar ne a cikin tso adi nama a karkashin fata.

Yankunan da suka dace don allurar subcutaneous sune ciki, kafaɗar kafada, da cinya. Idan ya cancanta, ci gaba da jiko shine ƙaddamar da ƙwayar adipose a ƙarƙashin fata a cikin ciki. Kowane sabon gabatarwar maganin Apidra ya kamata a aiwatar dashi a cikin sabon wuri.

Matsakaicin ƙwayar sashi mai aiki zai iya bambanta dangane da wurin allura na miyagun ƙwayoyi, aikin jiki na mai haƙuri, da sauran yanayi. An lura da sauri cikin abu mai aiki lokacin da allura zuwa bangon ciki.

Side effects

Hypoglycemia - sakamako wanda ba a ke so shi ne na maganin insulin, wanda zai iya faruwa idan aka yi amfani da allurar insulin da yawa, ya wuce bukatar sa.

Abubuwan ƙarancin halayen da aka lura a cikin gwaji na asibiti da ke hade da gudanar da miyagun ƙwayoyi an jera su a ƙasa gwargwadon tsarin tsarin kuma don rage yawan abin da ya faru. A bayanin yadda aka saba faruwa, ana amfani da sharuɗan masu zuwa: sau da yawa (> 10%), sau da yawa (> 1% da 0.1% da 0.01% da

Haihuwa da lactation

Babu cikakken isasshen bayani game da amfani da insulin glulisin a cikin mata masu juna biyu.

Karatuttukan karatu na haihuwar bai bayyana bambance-bambance tsakanin insulin glulisin da insulin mutum a cikin illolinsu akan ciki ba, ci gaban tayin (tayi), haihuwa da kuma ci gaba a cikin bayan haihuwa (duba Gwajin aminci na Preclinical).

Lokacin da aka tsara magunguna ga mata masu juna biyu, ya kamata a yi taka tsantsan. Kulawa sosai da glucose ya zama dole.

A duk cikin ciki, ya zama dole a kula da matsayin daidaiton yanayin aiki a cikin marassa lafiya da cututtukan cututtukan cututtukan fata na ciki. Bukatar insulin a cikin farkon farkon ciki na iya raguwa, yawanci yana ƙaruwa a cikin na biyu da na uku. Nan da nan bayan haihuwa, bukatar insulin ya ragu da sauri.

Ba'a sani ba ko insulin glulisin ya wuce cikin madara, duk da haka, yawanci insulin ba ya shiga cikin madara kuma ba'a sha shi bayan sarrafa bakin.

Matan da ke shayarwa na iya buƙatar daidaita sashin insulin da abinci.

Side sakamako

Hypoglycemia, mafi yawan raunin da ya dace ga aikin insulin, na iya haɓaka idan kashi na insulin yayi yawa idan aka kwatanta da buƙatar insulin.

Wadannan halayen masu haɗari masu alaƙa da amfani da miyagun ƙwayoyi, waɗanda aka lura yayin gwaji na asibiti, an gabatar dasu a ƙasa akan tsarin tsarin gabobin a cikin tsari na rage girman abin da ya faru (sosai:> 1/10, akai-akai> 1/100, 1/1000, 1/10000,

Yawan abin sama da ya kamata

Wataƙila ci gaban hypoglycemia sakamakon wuce haddi na insulin dangane da cin abinci da farashin kuzari na haƙuri.

Babu takamaiman bayanai game da yawan ƙwayar insulin glulisin. Koyaya, hypoglycemia na iya haɓakawa a cikin matakai.

Abubuwa na cututtukan hypoglycemia mai sauƙi ana iya kula dasu tare da glucose na baki ko Sweets. Sabili da haka, an ba da shawarar cewa marasa lafiya da masu ciwon sukari suna da ƙima na sukari, alewa, kukis ko ruwan 'ya'yan itace mai dadi tare da su. Abubuwan da ke faruwa na rashin ƙarfi na jini, lokacin da haƙuri ya gaji, za a iya bi da shi tare da glucagon (0.5 - 1 mg), wanda aka karɓa na intramuscularly ko subcutaneously ta mutumin da ya sami umarnin da ya dace, ko kuma a bi da shi ta hanyar glucose na ciki wanda ƙwararren likita ya gudanar. Hakanan ya kamata a gudanar da glucose a cikin ciki idan babu mai haƙuri game da glucagon na mintina 10-15. Bayan dawo da tunani, ana bayar da shawarar a ci abinci mai narkewa a cikin jiki don hana sake dawowa.

Bayan allura ta glucagon allura, ya zama dole a lura da marassa lafiya a asibiti domin gano musabbabin cututtukan cututtukan jini da hana ci gaba da irin wadannan abubuwan a gaba.

Yin hulɗa tare da wasu kwayoyi

Babu nazarin hulɗa da magunguna da aka gudanar. Dangane da ƙwarewar da aka samu tare da sauran kwayoyi masu kama da wannan, hulɗa na magunguna na mahimmancin asibiti ba su da tabbas.

Sanar da likitanka game da DUK magunguna da kuke sha, koda kuwa ya faru akan yanayin ta yanayin yanayin!

Wasu abubuwa suna shafar metabolism, saboda haka ana iya daidaita yawan insulin glulisin musamman ana sa ido sosai.

Abubuwan da zasu iya haɓaka tasirin glucose a cikin jini kuma ƙara haɓaka da haɓakar hypoglycemia sun haɗa da magungunan maganganu na bakin jini, maganin angiotensin-sauya masu hana enzyme, masu rashin biyayya, fibrates, fluoxetine, masu hana MAO, pentoxifylline, propoxyphene, salicylates da sulfibamide.

Abubuwan da zasu iya rage ayyukan gulukul-jini sun hada da glandon glucocorticosteroid, danazole, diazoxide, diuretics, glucagon, isoniazid, abubuwan da ake kira phenothiazine, somatropin, sympathomimetics (misali epinephrine adrenaline, salbutamol, terbutaline, hormones, e.g. , a cikin rigakafin hana baki), masu hana masu kariya da magungunan antipsychotic atypical (misali, olanzapine da clozapine).

Beta-blockers, clonidine, salts na lithium da barasa zasu iya haɓakawa da kuma raunana ayyukan rage glucose na jini. Pentamidine na iya haifar da hypoglycemia, wanda wani lokacin yakan shiga cikin hyperglycemia.

Bugu da ƙari, a ƙarƙashin rinjayar magunguna na juyayi kamar ß-blockers, clonidine, guanethidine da reserpine, alamun adrenergic antiregulation na iya zama mai laushi ko ba ya nan.

Jagororin Yardaitawa

Saboda karancin nazarin karfin jituwa, wannan magani bai kamata a gauraya shi da wasu magunguna wanin insulin na NPH na mutum ba.

Siffofin aikace-aikace

Canjin mai haƙuri zuwa sabon nau'in ko alama na insulin ya kamata a aiwatar da shi a ƙarƙashin kulawar likita. Canji a cikin nau'i na saki, alama (masana'anta), nau'in (daidaitaccen, NPH, jinkirin aiki, da sauransu), asalin (nau'in dabba) da (ko) fasahar samarwa na iya haifar da canji a sashi. Ana iya buƙatar daidaita sashin ƙwayar maganganu na bakin jini tare da magani na lokaci daya.

Rashin isasshen dosing ko dakatar da magani, musamman ma a cikin marasa lafiyar da ke fama da ciwon sukari, na iya haifar da cututtukan cututtukan zuciya da ketoacidosis - masu barazanar rayuwa.

Lokacin haɓakawar hypoglycemia ya dogara da tsarin aikin insulin wanda aka yi amfani dashi kuma, sabili da haka, na iya canzawa tare da canji a tsarin kulawa.

Yanayin da zasu iya canzawa ko rage alamun farkon cutarwar jiki sun haɗa da masu zuwa: ciwon sukari na dogon lokaci, kulawa mai zurfi tare da insulin, neuropathy na ciwon sukari, kwayoyi kamar ß-blockers, ko sauyawa daga dabba zuwa insulin mutum. Za'a iya buƙatar gyaran fuska idan mai haƙuri ya kara yawan aikinsa ko ya canza tsarin abincin. Yin motsa jiki nan da nan bayan cin abinci na iya ƙara haɗarin hawan jini.

Idan hypoglycemia ya haɗu bayan allura na analogs cikin sauri, to yana iya haɓaka a baya, idan aka kwatanta da allura ta insulin ɗan adam.

Idan ba'a gyara yanayin hypoglycemic da hyperglycemic ba, zai iya haifar da asarar hankali, ga wanda kuma mutuwar mai haƙuri.

Buƙatar haƙuri na insulin na iya canzawa yayin rashin lafiya ko damuwa na damuwa.

Hannun Syringe

Kafin amfani da alƙalaran murfin SoloStar, dole ne ka karanta umarnin a hankali don amfani da ke cikin wannan ƙaramin takarda.

Fom ɗin saki

3 ml kowane a cikin takaddun gilashin katako mai tsabta (nau'in I). An rufe akwatinan katako a gefe guda tare da daskararren bromobutyl kuma an yanke shi tare da filayen aluminium, a gefe guda tare da mai amfani da bromobutyl.

An ɗora Kwandon a cikin sikirin murfin SoloStar. 5 Ana sanya sirinji SoloStar a cikin kwali mai kwali tare da umarnin don amfani.