Umarnin don yin amfani da kwayoyi, analogues, bita

Lambar Takardar Rajista: P N011270 / 01-171016
Sunan kasuwanci na miyagun ƙwayoyi: Amoxicillin Sandoz®.
Sunan kasa da kasa mai zaman kansa: Amoxicillin.
Form sashi: allunan da aka sanya fim.

Bayanin
Kwala (sashi 0.5 g) ko m (sashi na 1.0 g) allunan biconvex, an hada da fim daga fari zuwa dan kadan mai launin shuɗi, tare da kwano a ɓangarorin biyu.

Abun ciki
1 kwamfutar hannu 1 of 0.5 g da 1.0 g ya ƙunshi:
Ainihin
Abunda yake aiki: amoxicillin (a cikin nau'in amohydillin trihydrate) 500.0 mg (574.0 mg) da 1000.0 mg (1148.0 mg), bi da bi.
Mahalarta: magnesium stearate 5.0 mg / 10.0 mg, povidone 12.5 mg / 25.0 mg, sitaci carboxymethyl sitaci (nau'in A) 20.0 mg / 40.0 mg, microcrystalline cellulose 60.5 mg / 121 mg
Shean fim: titanium dioxide 0.340 mg / 0.68 mg, talc 0.535 mg / 1.07 mg, hypromellose 2.125 mg / 4.25 mg.

Rukunin Magunguna
Kwayar maganin rigakafi na penisillins na semisynthetic.

Lambar ATX: J01CA04

Maganin magunguna

Pharmacodynamics
Amoxicillin wani abu ne wanda yake dauke da kwayoyin cuta wanda yake dauke da kwayoyin cuta. Tsarin aikin kwayar cuta na amoxicillin yana da alaƙa da lalacewar membrane na ƙwayoyin cuta a cikin matakan yaduwa. Amoxicillin musamman yana hana enzymes na membranes na kwayan cuta (peptidoglycans), sakamakon haifar da lamuransu da mutuwa.
Aiki da:
Gram-tabbatacce ƙwayoyin cuta
Bacillus anthracis
Corynebacterium spp. (ban da Carinnebacterium jeikeium)
Encerococcus faecalis
Listeria monocytogenes
Hakkin spp. (gami da cutar huda ciki da waje)
Staphylococcus spp. (ban da penicillinase samar da damuwa).
Gram-korau aerobic kwayoyin
Borrelia sp.
Escherichia coli
Haemophilus spp.
Helloriobacter pylori
Leptospira spp.
Neisseria spp.
Kare mirabilis
Salmonella spp.
Shigella spp.
Treponema spp.
Labarun
Sauran
Chlamydia spp.
Kwayoyin cutar Anaerobic
Bacteroides melaninogenicus
Clostridium spp.
Fusobacterium spp.
Kawaicin spp.
Rashin aiki da:
Gram-tabbatacce ƙwayoyin cuta
Staphylococcus (nau'in samar da lactamase)
Gram-korau aerobic kwayoyin
Acinetobacter spp.
Citrobacter spp.
Enterobacter spp.
Klebsiella spp.
Moraxella catarrhalis
Kare spp.
Bayanai spp.
Pseudomonas spp.
Serratia spp.
Kwayoyin cutar Anaerobic
Bacteroides spp.
Sauran
Mycoplasma spp.
Rickettsia spp.
Pharmacokinetics
Cikakken bioavailability na amoxicillin ya dogara da kashi kuma yana tsakanin 75 zuwa 90%. Kasancewar abinci baya shafar shan maganin. Sakamakon gudanar da maganin amoxicillin a cikin kashi ɗaya na 500 MG, maida hankali ne na miyagun ƙwayoyi a cikin plasma shine 6-11 mg / l. Bayan gudanarwar baka, mafi girman maida hankali ne kai bayan awa 1-2.
Tsakanin 15% zuwa 25% na amoxicillin yana ɗaure zuwa kariyar plasma. Magunguna yana sauri ya shiga cikin huhun huhu, ƙwanƙwashin hanji, ƙwayar kunne ta tsakiya, bile da fitsari. Idan babu kumburi da meninges, amoxicillin ya shiga cikin ƙwayar cerebrospinal a cikin adadi kaɗan. Tare da kumburi na meninges, maida hankali ne na miyagun ƙwayoyi a cikin ƙwayar cerebrospinal na iya zama 20% na taro a cikin jini na jini. Amoxicillin ya ratsa cikin mahaifa kuma ana samun shi da yawa a cikin madara mai nono.
Har zuwa 25% na kashi ana gudanarwa shine metabolized don samar da penicilloic acid mara aiki.
Kusan kashi 60-80% na amoxicillin an canza shi ta hanyar kodan a cikin sa'o'i 6-8 bayan shan maganin. Ana amfani da ɗan ƙaramin ƙwayar a cikin bile. Rabin rayuwar shine 1-1.5 hours. A cikin marasa lafiya da ƙarshen ƙarancin na koda, gawar rabin rayuwa ta bambanta daga 5 zuwa 20 hours. Magungunan yana warkar da cutar sankara.

Ana nuna Amoxicillin na cututtukan da ke haifar da kumburi da ke haifar da ƙwayoyin cuta marasa tsayayya:
• cututtuka na ciki da na ƙananan hanji da na jijiyoyin ENT (tonsillitis, m otitis media, pharyngitis, mashako, ciwon huhu, ƙonewar huhu),
• cututtukan cututtuka na cututtukan ƙwayar cuta na cututtukan ƙwayar cuta (cututtukan ƙwayar cuta, pyelonephritis, cututtukan cututtukan fata, cututtukan ƙwayar cuta na ƙwayar cuta, epididymitis, cystitis, adnexitis, zubar da ciki, zubar da ciki, da dai sauransu),
• cututtukan gastrointestinal: ƙwayar cuta ta ƙwayar cuta. Ana buƙatar buƙatar haɗin haɗin don cututtukan da ke haifar da ƙananan ƙwayoyin cuta anaerobic,
• cututtukan cututtuka da na kumburi da ƙwayar biliary (cholangitis, cholecystitis),
Rad lalata Helicobacter pylori (a hade tare da masu hana bututun injin, clarithromycin ko metronidazole),
• kamuwa da cuta fata da taushi,
• leptospirosis, listeriosis, cutar Lyme (borreliosis),
• endocarditis (ciki har da rigakafin endocarditis yayin tsarin hakori).

Contraindications

• tashin zuciya ga amoxicillin, maganin penicillin da sauran abubuwan magani,
• maganganun tashin hankali na kai tsaye nan da nan (misali, anaphylaxis) zuwa wasu maganin rigakafin beta-lactam kamar su celolosporins, carbapenems, monobactams (amsawar giciye),
• shekarun yara har zuwa shekaru 3 (don wannan nau'in sashi).

Tare da kulawa

• rashi aiki na renal,
• tsinkaya zuwa kabura,
• raunin abinci mai narkewa, tare da yawan amai da gudawa,
• rashin lafiyar rashin lafiyan datti,
• asma,
• zazzabi,
• cututtukan hoto ko bidiyo guda biyu,
• matattarar ƙwayar cutar kuturta,
• mononucleosis na kamuwa da cuta (saboda karuwar haɗarin fata mai kama da kurji a fata),
• a cikin yara sama da shekaru 3.

Yi amfani da lokacin daukar ciki da lokacin shayarwa

Nazarin dabbobi sun nuna cewa amoxicillin bashi da ciki, teratogenic da tasirin mutagenic akan tayi. Koyaya, ingantaccen nazari mai cikakken iko kan amfani da amoxicillin a cikin mata masu juna biyu, saboda haka, amfani da amoxicillin yayin daukar ciki zai yuwu ne kawai idan amfanin da ake tsammanin zai yiwa mahaifiyar fiye da girman hadarin da tayi.
Smallarancin maganin yana fitowa a cikin madarar nono, don haka lokacin da ake yin maganin tare da amoxicillin yayin shayarwa, ya zama dole a magance matsalar dakatar da shayarwa, tunda zawo da / ko candidiasis na mucosa na baki na iya haɓakawa, tare kuma da fahimtar ƙwayoyin rigakafin beta-lactam a cikin jariri wanda ke kan nono.

Sashi da gudanarwa

A ciki.
Kamuwa da cuta:
A matsayinka na mai mulkin, ana bada shawarar amfani da farji don ci gaba na kwanaki 2-3 bayan bacewar alamun cutar. Game da cututtukan cututtukan da ke haifar da β-hemolytic streptococcus, cikakkiyar kawar da pathogen yana buƙatar magani don akalla kwanaki 10.
Ana nuna alamun wariyar cutar don rashin yiwuwar gudanar da maganin baka da kuma magance cututtukan cututtukan fata.
Maganin maganin manya (gami da mara lafiyar tsofaffi):
Matsayi na yau da kullun:
Yawan da aka saba samu daga 750 MG zuwa 3 g na amoxicillin kowace rana a yawancin allurai. A wasu halaye, ana bada shawara don iyakance kashi zuwa 1500 MG kowace rana a yawancin magunguna.
Short hanya na far:
Rashin cututtukan urinary na ciki wanda ba a ɗauka ba: shan 2 g na miyagun ƙwayoyi sau biyu don kowane allura tare da tazara tsakanin allurai na awa 10-12.
Sashin yara (har zuwa shekaru 12):
Adadin yau da kullun ga yara shine 25-50 mg / kg / rana a cikin allurai masu yawa (matsakaicin 60 mg / kg / rana), gwargwadon nuni da tsananin cutar.
Yara masu nauyin sama da kilogiram 40 ya kamata su karɓi sigar girma.
Sashi don na koda gazawar:
A cikin marasa lafiya da gazawar haɓaka mai yawa, kashi ya kamata a rage. Tare da share koda na ƙasa da 30 ml / min, ana bada shawarar haɓaka tazara tsakanin allurai ko rage yawan allurai masu zuwa. A gazawar koda, gajerun darussan na maganin 3 g an contraindicated.

Manya (gami da marassa lafiyar):
Inirƙiraran ƙirƙirar ml / min Sashi Tsaka tsakanin allurai
> 30 Canji canje-canje ba a buƙata
10-30 500 MG 12 h

Tare da cututtukan jijiyoyin jini: Dole ne a ƙaddamar da 500 MG bayan hanyar.

Arancin aiki na yara a cikin yara waɗanda ke ƙasa da kilo 40
Inirƙiraran ƙirƙirar ml / min Sashi Tsaka tsakanin allurai
> 30 Canji canje-canje ba a buƙata
10-30 15 mg / kg 12 a

Rigakafin Endocarditis

Don rigakafin endocarditis a cikin marasa lafiya ba a ƙarƙashin maganin sa barci gaba ɗaya ba, ya kamata a sanya 3 g na amoxicillin 1 sa'a kafin tiyata kuma, idan ya cancanta, wani 3 g bayan 6 hours.
Anyi shawarar yara don rubanya amoxicillin a kashi 50 MG / kg.
Don ƙarin cikakkun bayanai da kwatancin nau'ikan marasa lafiya da ke cikin haɗari don endocarditis, koma zuwa jagororin hukuma na gida.

Side sakamako

A cewar Hukumar Lafiya ta Duniya (WHO), ana rarraba tasirin da ba a ke so gwargwadon yawan ci gaban su kamar haka: sau da yawa (≥1 / 10), sau da yawa (daga ≥1 / 100 zuwa rikicewar zuciya da jijiyoyin jini)
sau da yawa: tachycardia, phlebitis,
da wuya: rage karfin jini,
da wuya sosai: tsawaita ta TsT.
Rashin hankali daga jini da tsarin lymphatic
da wuya sosai: ana iya jujjuya leukopenia (gami da mummunar neutropenia da agranulocytosis), zazzagewar thrombocytopenia, hemolytic anemia, ƙara yawan coagulation jini, lokacin prothrombin,
ba a san mita ba: eosinophilia.
Rashin Tsarin Tsarin na rigakafi
da wuya: halayen kama da cutar magani,
da wuya sosai: halayen rashin lafiyan cuta masu yawa, da suka haɗa da angioedema, gigicewar anaphylactic, cutar sankara da rashin lafiyar fitsari,
ba a san tazarar: Jarisch-Herksheimer dauki (duba "Umarnin na Musamman").
Rashin lafiyar tsarin juyayi
sau da yawa: barci, ciwon kai,
da wuya: juyayi, tashin hankali, damuwa, ataxia, canjin hali, neuropathy na waje, damuwa, tashin hankali, tashin hankali, paresthesia, rawar jiki, rikicewa,
da ɗanɗana: rashin ƙarfi, bushewar zuciya, raɗaɗi, tashin zuciya, hangen nesa mai ƙoshin ji, wari da jijiyoyin gani, hallucinations.
Take hakkin yara da hanji
da wuya: karuwa hadaddiyar ƙwayar magani a
da wuya wuya: interstitial nephritis, crystalluria.
Rashin Tsarin ciki
sau da yawa: tashin zuciya, zawo,
a lokuta da dama: amai,
da wuya: dyspepsia, jin zafi a cikin yankin na epigastric,
da wuya sosai: cututtukan dake tattare da ƙwayoyin cuta * (gami da cuta mai karya garkuwar jiki) da gudawa, zawo tare da jini, bayyanuwar launin launi na yare (“mai gashi”) *,
ba a san mita ba: canjin ɗanɗano, stomatitis, glossitis.
Take hakkin hanta da kuma hanjin biliary
sau da yawa: ƙara yawan hankali bilirubin maida hankali,
da wuya sosai: hepatitis, cholestatic jaundice, ƙara yawan ƙwayoyin hepatic transaminases (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, γ-glutamyl transferase), ƙarancin hanta.
Musculoskeletal da raunin nama
da wuya: arthralgia, myalgia, cututtukan tendon, gami da tendonitis,
da wuya wuya: jijiyoyin wuya (yiwuwar biyu da kuma awanni 48 bayan fara magani), rauni na tsoka, rhabdomyolysis.
Rashin lafiyar fata da ƙananan ƙwayar cuta
sau da yawa: kurji
yawanci: urticaria, itching,
da wuya sosai: ɗaukar hoto, kumburin fata da hucin mucous, mai guba mai narkewa * (Lyell's syndrome), Stevens-Johnson syndrome *, erythema multiforme *, bullar exfoliative dermatitis *, matsanancin ƙwayar exanthematous pustulosis *.
Rashin hankali daga tsarin endocrine
da wuya: anorexia,
da wuya sosai: hypoglycemia, musamman a cikin masu fama da cutar sankara.
Rashin lafiyar tsarin
da wuya: bronchospasm, karancin numfashi,
da wuya sosai: ciwon huhu na huhu.
Cututtuka da cututtukan fata
da wuya: superinfection (musamman a cikin marasa lafiya da cututtukan cututtukan ƙwayar cuta ko juriya marasa ƙarfi),
da wuya sosai: candidiasis na fata da fatar mucous.
Janar cuta da rikice-rikice a wurin yin allura:
da wuya: rauni gaba ɗaya,
da wuya sosai: zazzabi.
* - mummunan halayen da aka rubuta a cikin lokacin sayarwa.

Yin hulɗa tare da wasu kwayoyi

Zai yuwu a kara lokacin narkexin yayin warkarwa tare da Amoxicillin Sandoz®. Ana buƙatar buƙatar daidaita sashi na digoxin.
Yin amfani da amoxicillin da probenecid na lokaci guda, wanda ke rage halayyar amoxicillin ta kodan kuma yana kara yawan amoxicillin cikin bile da jini, ba a bada shawarar ba.
Ya kamata a guji yin amfani da amoxicillin da sauran kwayoyi masu kashe kwayoyin cuta (macrolides, tetracyclines, sulfanilamides, chloramphenicol) saboda yiwuwar haɓakar tasirin antagonistic. Tare da amfani da aminoglycosides na lokaci guda da amoxicillin, tasirin synergistic mai yiwuwa ne.
Ba a shawarar amfani da amoxicillin da disulfiram lokaci guda.
Tare da yin amfani da maganin methotrexate da amoxicillin lokaci guda, haɓakar ƙwayar tsohuwar mai yiwuwa ne, mai yiwuwa saboda gushewar ƙirar tubular renal secretion na methotrexate ta amoxicillin.
Antacids, glucosamine, laxatives, aminoglycosides suna yin jinkiri kuma suna rage sha, ascorbic acid yana ƙaruwa da yawan amoxicillin.
Amoxicillin yana haɓaka tasiri na maganin rashin daidaituwa (rage ƙwayar microflora na hanji, rage hadaddiyar bitamin K da kuma bayanan prothrombin).
Amfani da ciki tare da hana kwayoyin hana daukar ciki na isrogen abinci na iya haifar da raguwar tasirin su da kuma kara hadarin “zubar jini”.
Littattafan bayanai sun bayyana kararraki na karuwa a cikin gwargwadon iko na duniya (INR) tare da haɗin acenocoumarol ko warfarin tare da amoxicillin. Idan ya cancanta, yin amfani da magungunan a lokaci guda tare da maganin rashin daidaituwa, lokacin prothrombin ko INR ya kamata a sa ido sosai a yayin jiyya ko lokacin da aka dakatar da miyagun ƙwayoyi, ana iya buƙatar daidaita sigar magungunan anticoagulants na kaikaice.
Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, magungunan anti-steroidal anti-inflammatory da sauran kwayoyi waɗanda ke toshe ɓoyayyiyar tubular suna ƙara haɗarin amoxicillin a cikin jini.
Allopurinol yana ƙara haɗarin haɓaka halayen fata. Yin amfani da amoxicillin da allopurinol ba a bada shawarar ba.

Umarni na musamman

Kafin ka fara amfani da amoxicillin, kana buƙatar tattara cikakken tarihin abubuwan da suka shafi tashin hankali game da cututtukan penicillins, cephalosporins, ko wasu maganin rigakafin beta-lactam. An bayyana mummunan, wani lokacin m, halayen rashin damuwa (anaphylactic halayen) ga penicillins. Hadarin irin wannan halayen shine mafi girma a cikin marasa lafiya tare da tarihin rashin yarda da rashin lafiyar jiki ga penicillins. Game da halayen rashin lafiyan, yana da mahimmanci don dakatar da magani tare da miyagun ƙwayoyi kuma fara madadin magani mafi dacewa.
Kafin ka tsara maganin Cutar Amoxicillin Sandoz®, kana buƙatar tabbatar cewa ire-iren ƙwayoyin cuta waɗanda ke haifar da cutar masu larura sun kasance suna kula da ƙwayar.Idan ana zargin mononucleosis mai kamuwa da cuta, bai kamata a yi amfani da maganin ba, tunda a cikin marasa lafiya da wannan cutar, amoxicillin na iya haifar da bayyanar fatar fata-kamar fatar fata.
Zai yuwu a haɓaka superinfection saboda haɓakar microflora wanda ba shi da hankali, wanda ke buƙatar canji mai dacewa a cikin maganin rigakafi.
Tare da hanya, ana buƙatar saka idanu kan yanayin aikin jini, hanta da kodan.
A cikin cututtukan cututtukan ciki da na kumburi da na hanji, tare da raɗaɗin zawo ko matsanancin ciki, ba a ba da shawarar ɗaukar ƙwayar Amoxicillin Sandoz® a ciki saboda yiwuwar ƙarancin sha.
Lokacin da ake magance zawo mai laushi tare da hanyar kulawa, ya kamata a guji magungunan antidiarrheal waɗanda ke rage motsin hanji, kuma za'a iya amfani da magungunan antolkararhehe kaolin ko attapulgite. Don tsananin zawo, nemi likita.
Tare da haɓakar cutar zazzabi mai saurin ci gaba, yaduwar cututtukan cututtukan cututtukan fata (wanda ya haifar da ƙwaƙwalwar Clostridium) ya kamata a cire su. A wannan yanayin, yakamata a dakatar da Amoxicillin Sandoz® kuma an wajabta maganin da ya dace.
Dole ne a ci gaba da yin magani na wasu awanni 48-72 bayan bacewar alamun asibiti na cutar.
Ta amfani da hanyoyin hana daukar ciki na kwayar cutar kwayar cutar kwayar cutar kwayar cutar kwayoyi da amoxicillin, sauran ko ƙarin hanyoyin hana haihuwa idan ya yiwu.
Ba a shawarar Amoxicillin Sandoz® don magance cututtukan ƙwayar cuta na ƙwayar cuta ta rashin ƙarfi saboda ƙwayoyin cuta.
Yayin magani, ba a bada shawarar ethanol ba.
Wataƙila ci gaban seizures a cikin rukuni na masu zuwa na marasa lafiya: tare da nakasa aikin na koda, yana karɓar ƙwayoyi masu ɗimbin yawa, tare da tsinkayarwa zuwa tashin hankali (tarihin: mawuyacin ɓacin rai, amai, raunin meningeal).
Bayyanarwar a farkon jiyya tare da amoxicillin na alamun kamar jigilar mahaifa, tare da zazzabi da kuma bayyanar cututtukan ƙwayar cuta, na iya zama alamomin yanayin cutar ƙwayar cutar ƙwayar cuta a cikin kwayar cutar. Irin wannan halayen yana buƙatar dakatar da maganin amoxicillin kuma ya kasance mai hana amfani da miyagun ƙwayoyi a nan gaba.
Lokacin da ake tsara magunguna ga marasa lafiya da ke fama da rauni na aikin ƙirar ƙira, daidaitawa kashi yana da mahimmanci daidai da matakin ƙetare (duba sashe "Sashi da Gudanarwa").
A cikin lura da cutar ta Lyme tare da amoxicillin, ci gaban Yarish-Herxheimer na iya yiwuwa, wanda sakamakon sakamako ne na ƙwayar cuta a cikin wakili na cutar - spirochete Borrelia burgdorferi. Wajibi ne a sanar da marasa lafiya cewa wannan yanayin sakamako ne sananne na maganin rigakafi kuma, a matsayinka na, yana wuce kansa.
Wani lokaci, an ba da rahoton karuwa a cikin prothrombin a cikin marasa lafiya da ke karɓar amoxicillin. Kwararrun likitocin da suka nuna aikin kulawa na lokaci daya na maganin rashin daidaituwa a jiki ya kamata a lura dasu. Sauya kashi na kwatankwacin maganin anticoagulants na iya zama dole.
Yayin shan Amxicillin Sandoz®, ana bada shawara cewa kayi amfani da adadin ruwa mai ruwa don hana samuwar lu'ulu'un amoxicillin a cikin fitsari.
Babban taro na amoxicillin a cikin jini da fitsari na iya shafar sakamakon gwajin gwaje-gwaje. Misali, amfani da Amoxicillin Sandoz® na iya haifar da urinal-tabbataccen urinalysis na glucose. Don ƙaddara wannan sigar, ana bada shawara don amfani da hanyar glucose oxidase.
Lokacin amfani da amoxicillin, ba za a iya samo sakamakon da ba daidai ba na tantance matakin estriol (estrogen) a cikin mata masu ciki.

Tasiri kan iya tuka motoci, abubuwan aiki

Nazarin game da tasirin amoxicillin akan iya tuki motocin, ba a gudanar da injunan ba. Yakamata a gargadi marassa lafiya game da yuwuwar amai da gudawa. Lokacin da abin da ya faru na abubuwan da suka faru masu rauni suka guji aikata waɗannan ayyukan.

Fom ɗin saki
Allunan da aka saka fim, 0.5 g da 1 g.
Sashi 0.5 g
Farko fakitin
Allunan 10 ko 12 a cikin burar PVC / PVDC / aluminum.
Sake karatun sakandare
Kowace ɗaukar kaya
1 blister (dauke da Allunan 12) a cikin kwali mai kwarjini da umarnin amfani.
Shirya don asibitoci
Blister 100 (dauke da Allunan 10) tare da daidai adadin umarnin don amfani a cikin kwali.
Sashi 1.0 g
Farko fakitin
Don allunan 6 ko 10 a cikin murfin PVC / PVDC / aluminum.
Sake karatun sakandare
Kowace ɗaukar kaya
2 blisters (dauke da Allunan 6) a cikin kwali mai kwaskwarima tare da umarnin don amfani.
Shirya don asibitoci
Blister 100 (dauke da Allunan 10) tare da daidai adadin umarnin don amfani a cikin kwali.

Yanayin ajiya
Adana a zazzabi da bai wuce 25 ° C.
Ayi nesa da isar yara.

Gargaɗi na musamman don zubar da samfurin ba amfani
Babu buƙatar rigakafin musamman yayin zubar da magani mara amfani.

Ranar karewa
Shekaru 4
Kada kayi amfani bayan ranar karewa wanda aka nuna akan kunshin.

Sharuɗɗan hutu
Da takardar sayan magani.

Mai masana'anta
Sandoz GmbH, Biohemistrasse 10, A-6250 Kundl, Austria.

Ya kamata a aika da sanarwa game da masu sayen 'yan kasuwa zuwa ZAO Sandoz:
125315, Moscow, Leningradsky Prospekt, 72, gini. 3
Waya: (495) 660-75-09,
Fax: (495) 660-75-10.