Yadda za a yi amfani da miyagun ƙwayoyi Gluconorm?

Sunan kasa da kasa - gluconorm

Abun ciki da nau'i na saki

Allunan mai rufe fim fari, zagaye, biconvex. Kwamfutar hannu 1 ta ƙunshi glibenclamide 2.5 MG, metformin hydrochloride 400 MG.

Fitowa: microcrystalline cellulose - 100 MG, sitaci masara - 20 MG, colloidal silicon dioxide - 20 MG, gelatin - 10 MG, glycerol - 10 MG, magnesium stearate - 7 MG, tsarkakakken talcum foda - 15 MG, croscarmellose sodium - 30 MG, sodium carboxymethyl sitaci - 18.3 MG, cellularphate - 2 MG, diethyl phthalate - 0.2 mg.

10 inji mai kwakwalwa - blister (1, 2, 3, 4) - fakitoci na kwali.
Guda 20. - blister (1, 2, 3, 4) - fakitoci na kwali.
30 inji mai kwakwalwa - blister (1, 2, 3, 4) - fakitoci na kwali.

Clinical da kungiyar magunguna

Oral hypoglycemic magani.

Rukunin Magunguna

Hypoglycemic wakili don maganin baka (sulfonylurea na ƙarni na II + biguanide).

Aikin magunguna

Gluconorm shine haɗin ƙayyadaddun haɗakar wakilai guda biyu na maganganu na ƙungiyoyi na magunguna daban-daban: metformin da glibenclamide.

Metformin yana cikin rukunin biguanides kuma yana rage matakin glucose a cikin jijiyoyin jini ta hanyar ƙara ƙarfin jijiyoyin kyallen takarda zuwa aikin insulin da haɓaka haɓakar glucose. Yana rage yawan carbohydrates a cikin narkewar abinci kuma yana hana gluconeogenesis a cikin hanta. Har ila yau, maganin yana da tasiri mai amfani akan bayanan lipid na jini, yana rage girman adadin cholesterol. LDL da triglycerides. Ba ya haifar da maganganun hypoglycemic.

Glibenclamide toungiyar ta samo asali na sulfonylurea na ƙarni na biyu. Yana ƙarfafa insulin insulin ta hanyar rage ƙwanƙwasa ƙwanƙwasa ƙwayar panc-sel, haɓaka haɓakar insulin da ɗaurin ɗaukar nauyin ƙwaƙwalwa, yana haɓaka sakin insulin, yana inganta tasirin insulin akan ƙwayar tsoka da haɓakar hanta, kuma yana hana lipolysis a cikin tsopose nama. Ayyukan Manzanni a mataki na biyu na insulin insulin.

Pharmacokinetics na Gluconorm

Lokacin gudanar da shi, sha daga ƙwayar gastrointestinal shine kashi 48-84. Lokaci don isa C_max - 1-2 awanni V_d - Lita 9-10. Sadarwar tare da sunadaran plasma kashi 95%.

Yana da kusan metabolized a cikin hanta tare da samuwar metabolites guda biyu masu aiki, wanda ɗayan ya cire ta, ɗayan kuma hanjin hanji. T_1/2 - daga 3 zuwa 10-16 hours

Bayan gudanar da baki, yana narkewa daga jijiyar ciki gaba daya, an sami kashi 20-30% na kashi a cikin feces. Cikakken bayanin halitta daga 50 zuwa 60%. Tare da shigowa na lokaci daya, shakar metformin zai ragu kuma yana jinkirta. An rarraba shi da sauri a cikin nama, kusan ba a ɗaura shi ga furotin plasma ba.

Yana cikin metabolized sosai ga rauni sosai kuma kodan ya keɓe shi. T_1/2 kamar awa 9-12

Type 2 ciwon sukari a cikin manya:

- tare da rashin ingancin hanyoyin maganin abinci, motsa jiki da aikin da ya gabata tare da metformin ko glibenclamide,

- don maye gurbin maganin da ya gabata tare da kwayoyi biyu (metformin da glibenclamide) a cikin marasa lafiya tare da tsayayyen ingantaccen tsarin glucose na jini.

Sashi lokacin da hanyar aikace-aikace na Gluconorm

Ana amfani da miyagun ƙwayoyi a baki, tare da abinci. Adadin maganin yana maganin likita ne daban-daban ga kowane mara lafiya, gwargwadon matakin glucose na jini.

Yawancin lokaci kashi na farko shine 1 shafin. (400 MG / 2.5 MG) / rana. Kowane mako 1-2 bayan fara magani, ana gyara kashi na maganin yana dogara da matakin glucose na jini. Lokacin maye gurbin maganin haɗuwa na baya tare da metformin da glybeklamide, an tsara allunan 1-2. Gluconorm ya danganta da satin da ya gabata na kowane bangare.

Matsakaicin maganin yau da kullun shine Allunan 5.

Side sakamako

Allergic da immunopathological halayen: da wuya - urticaria, erythema, itching fata, zazzabi, arthralgia, proteinuria.

Daga gefen carbohydrate metabolism: hauhawar jini zai yiwu.

Daga tsarin hawan jini: da wuya - leukopenia, thrombocytopenia, erythrocytopenia, da wuya - agranulocytosis, hemolytic ko megaloblastic anemia, pancytopenia.

Daga gefen tsarin juyayi na tsakiya: ciwon kai, mara nauyi, rauni, gajiya, da wuya - paresis, raunin hankali.

Halayyar maganin cututtukan cututtukan fata: da wuya - ɗaukar hoto.

Daga cikin hanji da hanta: da wuya - tashin zuciya, amai, ciwon ciki, asarar ci, "ƙarfe" dandano a bakin, a wasu yanayi - cholestatic jaundice, ƙara yawan aiki na hanta enzymes, hepatitis.

Daga gefen metabolism: lactic acidosis.

Sauran: m dauki of giya rashin haƙuri bayan shan, bayyana ta rikitarwa daga cikin wurare dabam dabam da na jijiyoyin jini da kuma na numfashi (disulfiram-kamar dauki: vomiting, ji ​​na zafi a fuska da babba jiki, tachycardia, dizziness, ciwon kai).

Contraindications Gluconorm

- nau'in ciwon sukari na 1

- cututtuka masu kamuwa da cuta, manyan ayyukan tiyata, raunin da ya faru, konewa mai yawa da sauran yanayin da ke buƙatar maganin insulin,

- mai ciwon sukari ketoacidosis, mai ciwon sukari, mai ciwon sukari,

- matsanancin yanayi wanda zai haifar da canji ga aikin koda (fitsari, kamuwa da cuta, girgiza),

- Cuta mai raɗaɗi ko cututtukan da ke tattare da raunin nama (rashin ciwan zuciya ko na numfashi, rauni na baya bayan nan, amai),

- Yi amfani da aƙalla awanni 48 kafin da a cikin awanni 48 bayan gudanar da karatun radioisotope ko X-ray tare da gabatarwar iodine mai ɗauke da sigar matsakaici,

- riko da karancin kalori (kasa da adadin kuzari 1000 / rana),

- raunin koda na ciki,

- sarrafa miconazole na lokaci daya,

- rashin shan barasa, rashin shan barasa,

- lactic acidosis (gami da tarihi),

- lokacin shayarwa,

- Hypersensitivity to metformin, glibenclamide ko wasu abubuwan da ake amfani da su na sulfonylurea, har ma da abubuwan taimako.

Ba'a ba da shawarar yin amfani da miyagun ƙwayoyi a cikin mutanen da suka haura shekaru 60 waɗanda ke yin aiki na zahiri, wanda ke da alaƙa da haɓakar haɗarin haɓakar lactic acidosis a cikinsu.

Tare da taka tsantsan: cututtukan febrile, rashin ƙarfi adrenal, hauhawar tsoka da damuwa, cututtukan thyroid tare da aiki mai rauni.

Haihuwa da lactation

A lokacin daukar ciki, amfani da gluconorm ya saba. Lokacin da ake shirin yin ciki, da kuma lokacin da ake yin ciki yayin lokacin shan Gluconorm, yakamata a dakatar da miyagun ƙwayoyi kuma ya kamata a tsara maganin insulin.

Gluconorm yana cikin garkuwar nono, kamar yadda metformin ya shiga cikin nono. A wannan yanayin, dole ne canzawa zuwa maganin insulin ko dakatar da shayarwa.

Yi amfani da shi don aikin hanta mai rauni

Contraindicated a cikin hanta gazawar.

Yi amfani da shi don aikin keɓaɓɓiyar aiki

Amfani da shi yana cikin lalacewa na rashin ƙarfi na yara da m yanayi wanda zai iya haifar da canji ga aikin koda (fitsari, ciwo mai tsanani, girgiza),

Yi amfani da shi a cikin tsofaffi marasa lafiya

Ba'a ba da shawarar yin amfani da miyagun ƙwayoyi a cikin mutanen da suka haura shekaru 60 waɗanda ke yin aiki na zahiri, wanda ke da alaƙa da haɓakar haɗarin haɓakar lactic acidosis a cikinsu.

Umarnin na musamman don shigarwa

Manyan hanyoyin tiyata da raunin da ya faru, konewa mai yawa, cututtuka masu yaduwa tare da cututtukan febrile na iya buƙatar dakatar da magani da kuma alƙawarin maganin insulin.

Wajibi ne a kula da matakin glucose a cikin jini akai-akai a cikin komai a ciki kuma bayan cin abinci.

Ya kamata a faɗakar da marasa lafiya game da haɗarin haɗarin hypoglycemia a cikin yanayin ethanol, NSAIDs, da kuma matsananciyar yunwa.

Daidaitawar magani ya zama dole don wuce gona da iri da motsin rai, canji a abinci.

Yayin magani, ba da shawarar shan giya ba.

Awanni 48 kafin a yi tiyata ko a gudanar da wani abu wanda yake dauke da maganin fitsari a cikin aidin, ya kamata a dakatar da aikin gluconorm. An bada shawarar sake maganin gluconorm bayan awa 48.

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa

A lokacin jiyya, dole ne a kula sosai yayin tuki motoci da shiga cikin wasu ayyukan masu haɗari waɗanda ke buƙatar haɓakar jawo hankali da saurin halayen psychomotor.

Yawan abin sama da ya kamata

Yawan abin sha ko gaban haɗarin abubuwa na iya haifar da ci gaban lactic acidosis, kamar yadda Metforminum bangare ne na shiri. Lokacin da alamun cututtukan lactic acidosis suka bayyana (vomiting, zafi na ciki, rauni gaba ɗaya, ƙwayar tsoka), dole ne a daina shan magani. Lactic acidosis yanayi ne wanda ke buƙatar kulawa da lafiya na gaggawa, lura da lactic acidosis ya kamata a gudanar da shi a asibiti. Mafi kyawun magani shine maganin hemodialysis.

Doaryewar overdose na iya haifar da ci gaban hypoglycemia saboda kasancewar glibenclamide a cikin shirye-shiryen. Bayyanar cututtuka na hypoglycemia: yunwa, wuce kima, rashin ƙarfi, palpitations, pallor na fata, paresthesia na bakin mucosa, rawar jiki, damuwa gaba ɗaya, ciwon kai, matsananciyar damuwa, tashin hankali na barci, ma'anar tsoro, rashin daidaituwa game da motsi, raunin jijiyoyin wucin gadi. Tare da ci gaban hypoglycemia, marasa lafiya na iya rasa ikon kamewa da sanin su.

Tare da hypoglycemia mai sauƙi ko matsakaici, ana ɗaukar dextrose (glucose) ko maganin sukari a baki. Game da cutar hypoglycemia mai tsanani (asarar hankali), ana aiwatar da maganin 40% na glucagon mafitsara (v / m, s / c) iv. Bayan ya dawo da hankali, dole ne a bai wa mara lafiya abinci mai wadataccen abinci a cikin carbohydrates don guje wa sake haɓakar cutar sankarar fata.

Haɗi tare da Sauran Magunguna

Barbiturates, corticosteroids, adrenostimulants (epinephrine, clonidine), magungunan antiepileptik (phenytoin), jinkirin tashar alli mai laushi, inhibitors na carbonic anhydrase (acetazolamide), thiazide diuretics, chlortalidone, furosemide, diazanazide, triazene diazent , morphine, ritodrine, salbutamol, terbutaline, glucagon, rifampicin, iodine-mai dauke da kwayoyin hodar iblis, gishirin lithium, a cikin manyan allurai - nicotinic acid, chlorpromazine, maganin hana haihuwa da estrogens.

ACE inhibitors (captopril, enalapril), tsoffin ƙwayoyin Harkokin tarihin HAM suna haɓaka tasirin maganin ƙwaƙwalwar ƙwayar cuta₂masu karɓa (cimetidine), jami'ai na antifungal (miconazole, fluconazole), NSAIDs (phenylbutazone, azapropazone, oxyphenbutazone), fibrates (clofibrate, bezafibrat), magungunan rigakafin tarin fuka (ethionamide), salicytates, anticoagulant antagon, MAO, sulfonamides mai aiki da dogon lokaci, cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, bloug secretion, bloerpine, bromocriptine, benawa, sitiri, da sauransu magungunan hypoglycemic (acarbose, biguanides, insulin), allopurinol.

Magungunan acidifying acid (ammonium chloride, alli chloride, ascorbic acid a cikin manyan allurai) suna inganta sakamako ta hanyar rage darajar rarrabuwa da haɓaka reabsorption na glibenclamide.

Ethanol yana ƙaruwa da alama na lactic acidosis.

Metformin yana rage C_max da kuma T_1/2 furosemide ta hanyar 31% da 42.3%, bi da bi.

Furosemide yana ƙaruwa C_max metformin da kashi 22%.

Nifedipine yana ƙara sha, C_max yana rage jinkirin kawar da metformin.

Magungunan cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren da vancomycin) waɗanda aka ɓoye a cikin tubules suna gasa don tsarin jigilar tubular kuma suna iya haɓaka C tare da tsawan magani_max 60% metformin.

Sharuɗɗan hutu na kantin

Magungunan magani ne.

Sharuɗɗan da yanayin ajiya

Ya kamata a adana miyagun ƙwayoyi a bushe, kare shi daga haske, daga nesa da yara a zazzabi da bai wuce 25 ° C ba. Rayuwar shelf shine shekaru 3.

Yin amfani da miyagun ƙwayoyi Gluconorm kawai kamar yadda likita ya umarta, umarnin suna don tunani!

Saki siffofin da abun da ke ciki

Ana samar da miyagun ƙwayoyi a cikin nau'ikan allunan. 1 kwamfutar hannu 1 ya ƙunshi 2.5 mg na glibenclamide da 400 mg na metformin hydrochloride azaman abubuwa masu aiki. Su ne zagaye a siffar. Launi - daga fari zuwa fari fari.

Ana buƙatar gluconorm a cikin magani don magance ciwon sukari.

Aikin magunguna

Metformin yana cikin rukuni na abubuwa da ake kira biguanides. Matsayin sukari a cikin jini lokacin da aka dauki shi ya ragu saboda gaskiyar cewa ƙwaƙwalwar ƙwayar jijiyoyin jiki zuwa ayyukan insulin yana ƙaruwa. Haɓaka glucose yana aiki sosai. Carbohydrates ba su cika saurin narkewa cikin tsarin narkewa ba. Samuwar glucose a cikin hanta yana sauka a hankali. Cakuda cholesterol a cikin jini yana raguwa. Hypoglycemia ba shi da ikon haddasawa.

Game da glibenclamide, an lura cewa yana da asali na sulfonylurea na ƙarni na biyu. Yana kunna samar da insulin, fitarwarsa, yana rage jinkirin aiwatar da lipolysis a cikin tsopose nama.

Matsayin sukari na jini yayin shan Gluconorm yana raguwa saboda gaskiyar cewa ƙwaƙwalwar ƙwayar jijiyoyin jiki zuwa aikin insulin yana ƙaruwa.

Pharmacokinetics

Mafi girman taro na glibenclamide a cikin jini an yi shi awanni 1-2 bayan shan kwayoyin. 95% hade da sunadaran plasma jini. Lalata kusan 100% na faruwa a hanta. Mafi karancin rabin rayuwa shine 3 hours, matsakaicin na iya kaiwa awanni 16.

Metformin yana da 50-60% bioav available. Tattaunawa tare da sunadaran plasma na jini kadan ne, rarrabawa akan kyallen za'a iya bayyana su a zaman daidaiton tsari. Ba shi da ƙarfi a rarrabe, keɓe cikin kodan. Rabin-rayuwa shine awa 9-12.

Mafi girman taro na glibenclamide a cikin jini an yi shi awanni 1-2 bayan shan kwayoyin.

Contraindications

Ba za a iya aiwatar da jiyya tare da miyagun ƙwayoyi ba lokacin da mai haƙuri yana da waɗannan yanayi:

• hawan jini,
• cututtukan da ke da alaƙa da tsohuwar ƙwayar tsoka: rashin ƙarfi na zuciya, ƙwaƙwalwar zuciya da rikicewar tashin zuciya, girgiza,
• mai ciwon sukari ketoacidosis,
• nau'in ciwon sukari guda 1
• lactic acidosis da shimfidar ruwa,
• gagarumin ƙonewa ko tafiyar matakai masu buƙatar insulin gaggawa,
• susara yawan mai saukin kamuwa da kayan aiki na yau da kullun.

Ba za a iya aiwatar da jiyya tare da miyagun ƙwayoyi ba lokacin da mai haƙuri yana da ƙarin yawan yiwuwar zuwa manyan abubuwan da ke cikin maganin.
Ba za a iya aiwatar da jiyya tare da miyagun ƙwayoyi ba lokacin da mai haƙuri ya kamu da ciwon sukari na 1.
Ba za a iya aiwatar da jiyya tare da miyagun ƙwayoyi lokacin da mai haƙuri yana da infarction na zuciya.

Tare da ciwon sukari

Kafin shan kwayoyin, kowane mai haƙuri ya kamata yayi nazarin umarnin don kada ya cutar da lafiyar su. Ya kamata a wajabta maganin ta hanyar likitan da ya ba da maganin. Ya yanke shawara akan mafi kyau matakin bisa ga matakin matakan glucose a cikin jini wanda aka rubuta a cikin mai haƙuri a ƙayyadadden lokaci. Mafi sau da yawa, ana la'akari da abinci.

Mafi girman magani a rana ba zai iya zama sama da allunan 5 ba. Ainihin, shine kwamfutar hannu 1 a kowace rana (400 MG / 2.5 MG). Daga farkon farawar, kowane mako 1-2 ana iya gyara hanya, kamar yadda likita yake lura da canji a matakan glucose na jini. Idan ya fadi, to, ashe, ya kamata a rage kashi.

Ya kamata a wajabta maganin ta hanyar likitan da ya ba da maganin.

Hematopoietic gabobin

A matsayin mara saukin ratsa jiki daga tsarin haiatopoietic, haɓakar leukopenia, thrombocytopenia yana faruwa. Kasa da sau da yawa, raguwar adadin leukocytes, megaloblastic anemia yana haɓaka.

A matsayin saukin kai tsaye daga tsarin na haiatopoietic, haɓakar leukopenia yana faruwa.

Tasiri kan ikon sarrafa abubuwan inji

Sakamakon bayyanar cututtuka na tsarin juyayi na tsakiya, ya fi dacewa a guji sarrafa kayan aikin.

Sakamakon bayyanar cututtuka na tsarin juyayi na tsakiya, ya fi dacewa a guji sarrafa kayan aikin.

Yi amfani da lokacin daukar ciki da lactation

Bai kamata a sha magungunan ba yayin gestation. Idan akwai buƙatar ciwon sukari, wannan ya kamata a yi shi da ilimin insulin.

Ana tara Metformin a cikin madara. Wannan yana nufin cewa yayin aikin jiyya, ya kamata ku dakatar da magani tare da miyagun ƙwayoyi ko watsi da shayarwa kuma canja wurin yarinyar zuwa wucin gadi.

Cutar Gluconorm

Idan kashi da likitan ya ba da shawarar ya wuce mahimmanci, mai haƙuri na iya haɗuwa da lactacide, magani wanda ya kamata a gudanar dashi a cikin tsararren yanayi tare da maganin hemodialysis. Hypoglycemia na iya faruwa, wanda zai bayyana kansa ta hanyar bayyanar da jin yunwar, tashin hankali, matsalolin bacci na ɗan lokaci da kuma rikicewar jijiyoyin jiki.

Halayen magunguna

Gluconorm magani ne wanda ya haɗu da magunguna na azuzuwan magani daban-daban bisa ga tsarin aikin.

Abubuwan da ke cikin asali na yau da kullun shine metformin, wakili na biguanides, wanda ke daidaita abubuwan kwantar da hankali ta hanyar inganta juriyar sel zuwa insulin nasu da kuma haɓaka amfani da glucose ta kyallen. Bugu da kari, biguanide yana hana shaye-shayen carbohydrates kuma yana hana samar da glucose a cikin hanta. Yana haɓaka daidaiton ƙwayoyi da mai mai yawa, adana ingantaccen taro game da nau'ikan cholesterol da triglycerol.

Glibenclamide, sashi na biyu mai aiki a cikin takardar sayan magani, a matsayinta na wakilin aji na biyu na tsarin sulfonylurea, yana haɓaka samar da insulin tare da taimakon cells-sel na fitsari da ke da alhakin wannan aikin. Yana kare su daga mummunan glucose, inganta juriya na insulin da ingancin ligaments tare da sel. Sakin insulin da aka saki yana raye sosai yana sha kan yawan glucose ta hanta da tsokoki, sabili da haka, ba a kafa jarirsa a cikin kitse mai ba. Abubuwa suna aiki akan kashi na 2 na samar da insulin.

Fasali na pharmacokinetics

Bayan shiga cikin ciki, glibenclamide yana dauke da kashi 84%. Cmax (babban matakinsa) ya kai bayan awa 1-2. Rarraba ta girma (Vd) shine lita 9-10. Abubuwan da ke cikin sunadaran sunadarai na jini da kashi 95%.

Abun da ke cikin hanta an canza shi tare da sakin 2 metabolites na tsaka tsaki. Ofayansu yana kawar da hanji, na biyu - ƙodan. Rabin rayuwar T1 / 2 yana tsakanin awanni 3-16.

Bayan shiga tsarin narkewa, ana amfani da metformin a cikin ƙwaƙwalwa, babu abin da ya wuce 30% na kashi ya zauna a cikin stool. Ingancin biguanide bai wuce kashi 60% ba. Tare da cin abinci mai layi guda daya na abubuwan gina jiki, shan maganin yana rage gudu. An rarraba shi cikin sauri, baya shiga cikin sadarwa tare da kariyar plasma.

Gluconorm sashi tsari da abun da ke ciki

Gluconorm, hoto wanda za'a iya gani a wannan sashin, yana shiga cibiyar sadarwar kantin magani ta hanyar allunan zagaye na convex tare da farin harsashi. A fashewar, inuwa na miyagun ƙwayoyi yana da launin toka. A cikin kwamfutar hannu guda ɗaya akwai kayan masarufi guda biyu a cikin waɗannan rakodi masu zuwa: metformin - 400 mg, glibenclamide - 2.5 g. Supara tsari tare da filler: talc, cellulose, sitaci, glycerol, cellacephate, gelatin, magnesium stearate, croscarmellose sodium, sodium carboxymethyl sitaci, silikodi dioxide diethyl phthalate.

An tattara magungunan a cikin akwaku 10 ko 20. a cikin sel wanda aka yi da aluminium. A cikin kwali na kwali na iya zama daga faranti 2 zuwa 4. Don Gluconorm, Farashin yana da kusan kasafin kuɗi: daga 230 rubles, sun saki maganin sayen magani. Rayuwar shiryayye daga allunan shine shekaru 3. Magungunan ba ya buƙatar yanayi na musamman don ajiya.

Yadda ake amfani da Gluconorm

Don Gluconorm, umarnin don amfani da rubutattun allunan ciki tare da abinci. Likita ya kirga kwatancen daban-daban, tare da yin la’akari da halaye na hanyar cutar, aladuwar cututtuka, shekaru da yanayin masu ciwon suga, da kuma yadda jikin yake shan maganin. A matsayinka na mai mulkin, fara da kwamfutar hannu 1 / rana. Bayan mako daya ko biyu, zaku iya kimanta sakamakon, kuma tare da isasshen inganci, daidaita al'ada.

Idan Gluconorm ba magani bane na farawa, lokacin maye gurbin lokacin magani na baya, ana ba allunan 1-2 da aka yi la'akari da ka'idojin magunguna na baya. Mafi girman adadin allunan da za a iya ɗauka kowace rana guda 5 ne.

Taimaka tare da yawan wuce haddi

Kasancewar metformin a cikin tsari yakan haifar da rikicewar hanji, wani lokacin kuma lactic acidosis. Tare da bayyanar cututtuka na rikitarwa (bugun tsoka, rauni, jin zafi a cikin yankin na epigastric, amai), an dakatar da maganin. Tare da lactic acidosis, wanda aka azabtar yana buƙatar asibiti mai gaggawa. Dawo da shi tare da cutar sankara.

Kasancewar glibenclamide a cikin dabara ba ya hana ci gaban hypoglycemia. Yana yiwuwa a gane yanayi mai haɗari ta hanyar ci, ba a kamewa ba, karuwar gumi, tachycardia, rawar jiki, fatar jiki, isonnia, paresthesia, dizziness da ciwon kai, damuwa. Tare da wani nau'i mai sauƙi na munafukai, idan wanda aka azabtar ba shi da masaniya, ana ba su glucose ko sukari. Tare da suma, glucose, dextrose, glucagon (40% rd) ana allurar iv, im ko a karkashin fata. Bayan mai haƙuri ya sake farfaɗo, ana ciyar da shi tare da samfurori tare da carbohydrates mai sauri, tun da juyawa a cikin wannan halin sau da yawa yakan faru.

Sakamakon Cutar Magunguna

Hadin gwiwa tare da ACE inhibitors, NSAIDs, antifungal magunguna, fibrates, salicitates, anti-tarin fuka, β-adrenergic blockers, guanethidine, MAO inhibitors, sulfonamides, chloramphenicol, tetracycopyridinum, tetracycodiaminophenide, tetrazinopyumumumum, tedozinopyumumumumumum, tetrazinoin, tetrazinoin, tetrazinoin, tetrazinoin, tetrazinoin, tetrazinoin, tedozinopyrinum, tedozinopyrinum, tedozinoin, tedozinopyrinum, tedozinopyrinum, tedozinopyrinum, tedozinopyum, tedozinoin, tetrazinoin, tetrazinointe .

Ayyukan hypoglycemic na Gluconorm an rage shi daga tasirin adrenostimulant barbiturates, corticosteroids, magungunan rigakafi, diuretics (magungunan thiazide), furosemide, chlortalidone, triamteren, morphine, ritodrin, glucagon, hormones thyroid (a cikin hakan ne oestra, iodine, da sauransu).

Magungunan acid-haɓakar ƙwayar ƙwayar cuta suna aiki a matsayin mai tabbatar da inganci ta hanyar rage rarrabuwar kawuna da haɓaka abubuwan kwantar da hankali na gluconorm. Ethanol yana ƙaruwa da alama na lactic acidosis. Metformin yana cutar da magunguna na furosemide.

Sakamakon mara amfani

Metformin ɗayan amintaccen magani ne na lafiya, amma, kamar kowane magani na roba, yana da tasirin sakamako. Daga cikin abubuwanda suka zama ruwan dare akwai cuta, wanda ke ɓoye a cikin yawancin masu ciwon sukari bayan ƙarshen lokacin daidaitawa akan nasu. Glibenclamide shima kayan gwaji ne na lokaci-lokaci tare da babban tushe mai inganci da aminci. Yanayin da aka jera a cikin tebur yana da wuya, amma dole ne a yi nazarin umarnin kafin a fara jiyya.

Wanene ya nuna kuma ya ba da izini ga Gluconorm

Allunan an tsara su ga masu ciwon sukari tare da nau'in cuta na 2, idan gyaran salon rayuwa da magani na baya bai bayar da ikon sarrafa glycemic 100% ba. Idan yin amfani da magunguna daban-daban guda biyu (Metformin da Glibenclamide) suna ba da izinin biyan diyya na sukari, kuma yana da kyau maye gurbin hadaddun tare da magani ɗaya - Glucanorm.

Kada kayi amfani da Gluconorm tare da:

• Type 1 ciwon sukari
• Hypoglycemia,
• Ketoacidosis na masu fama da cutar siga, coma da precoma,
• Rys dysfunctions da yanayin tashin hankali,
• Dysfunctions hanta,
• Yanayi ya haifar da yunwar oxygen ta kyallen takarda (tare da ciwon zuciya, bugun zuciya, rawar jiki, gazawar numfashi),
• Ciwon ciki
• Amfani da miconazole na lokaci daya,
• Halin da ke ba da shawara ga canji na ɗan lokaci zuwa insulin (yayin aiki, raunin da ya faru, cututtuka, wasu gwaje-gwaje ta amfani da alamomi dangane da aidin),
• Almubazzaranci,
• Lactic acidosis, gami da tarihin likita,
• Haihuwa da lactation
• Hypocaloric (har zuwa 1000 kcal) abinci mai gina jiki,
• Hypersensitivity ga abubuwan da ke cikin tsari.

Amfani da Gluconorm ta Mahaifa da Marayu

Ko da a matakin shirin yaro, Gluconorm ya kamata a maye gurbin shi da insulin, tun da contraindicated magani ne a cikin wannan yanayin. Lokacin da aka ciyar da madara nono, hane-hane ya kasance cikakke, tunda maganin yana ratsa ba kawai ta cikin mahaifa tayin ba, har ma cikin madara. Zabi tsakanin insulin da canzawa da yaro zuwa ciyarwar mutum yakamata yayi la’akari da matsayin hadarin ga uwar da kuma illar cutar ga jaririn.

Umarni na musamman

Raunin da ya faru da mummunan aiki, cututtukan cututtuka tare da zazzabi, suna ba da shawarar jigilar haƙuri na ɗan lokaci zuwa insulin.

Ya kamata a faɗakar da masu ciwon sukari game da haɗarin haɓakar ƙwayar cuta tare da amfani da NSAIDs, barasa, ethanol na kwayoyi, da rashin abinci mai gina jiki na yau da kullun.

Tare da canza salon rayuwa, abinci, motsin rai da hauhawar motsa jiki, canji a cikin magunguna ya zama dole.

Idan za a bincika mara lafiyar ta yin amfani da alamomin abun ciki na aidin, ana soke gluconorm a cikin kwana biyu, tare da maye shi da insulin. Kuna iya komawa zuwa tsarin kula da jinya da ya gabata ba da sa'o'i 48 ba bayan binciken.

Za a rage tasirin Gluconorm sosai idan mai haƙuri bai bi abinci mai ƙanƙan da kai ba, yana jagorantar yanayin rayuwa, baya sarrafa sukari a kullun.

Gluconorm - analogues

Dangane da lambar ATX ta mataki na 4, sun zo daidai da Gluconorm:

Zabi da maye gurbin miyagun ƙwayoyi suna iyakance ne a cikin ikon gwani. Gano kansa da magani kai ba tare da yin la’akari da duk halayen wani gabobin halitta na iya zama sakamakon mummunan sakamako ba.

Nazarin masu ciwon sukari

Game da sake duba cututtukan Gluconorm masu ciwon sukari galibi suna rikitarwa. Wasu suna jayayya cewa miyagun ƙwayoyi ba su taimaka ba, akwai wasu abubuwan ban mamaki a gefe, gami da samun nauyi. Wasu kuma sun ce babban wahalar magani game da maganin shine a zabin sashi, sannan sukari ya koma daidai. Game da shayi na ganye "Altai 11 Gluconorm tare da blueberries" tabbatacce sake dubawa: yana taimakawa ci gaba da hangen nesa, inganta halayyar mutum.

Gluconorm magani ne mai sauƙin amfani tare da ingantaccen bincike da kuma aikin kayan aikin asibiti. Anyi amfani da magungunan Biguanides da magungunan sulfanilurea don magance cututtukan type 2 na fiye da rabin ƙarni, kuma sababbin nau'ikan magungunan maganin cututtukan cutar ba suce ikonsu ba.

Yin hulɗa tare da wasu kwayoyi

Ba'a ba da shawarar don amfani da magani na lokaci daya tare da fenfluramine na miyagun ƙwayoyi, cyclophosphamide, ACE inhibitors, magungunan antifungal, kamar yadda suke haɓaka tasirin maganin.

Thiazide diuretics dauke da sinadarin iodine thyroid na iya raunata ayyukanta.

Ba da shawarar don amfani da jituwa tare da fenfluramine.

Nazarin Gluconorm

Dukansu likitoci da marasa lafiya da aka kula da su tare da miyagun ƙwayoyi suna barin kyakkyawan bita.

D.E. Tikhonov, GP, Ryazan: “Magungunan sun nuna kyakkyawan sakamako a cikin lura da ciwon sukari na 2. Marasa lafiya suna jin daɗi sosai. ”

O.D. Ivanova, masanin ilimin endocrinologist, Moscow: “Na dauki magani daya daga cikin mafi kyawun magani don maganin ciwon sukari na 2, saboda yana taimakawa da sauri kuma a zahiri ba ya haifar da bayyanar da mummunan sakamako. Zan nada shi sau da yawa. "

Gluconorm Type 1 da ciwon sukari 2

Alina, ɗan shekara 29, Bryansk: “Dole ne a yi mini jinya don wannan mummunan cuta kamar ciwon sukari. Farjin ya daɗe, amma yanayin ya inganta sosai. Saboda haka, zan iya bayar da shawarar wannan maganin. ”

Ivan, ɗan shekara 49, Ufa: “Aka ɗauke ni da magani a asibiti. Na gamsu da komai, gami da kula da likitoci da ƙwarewar su. Sunyi nazari da ni kuma, gwargwadon sakamakon, sun ba da kwatancen magani. Zan iya kiran wannan magani da inganci kuma in ba da shi ga duk masu fama da ciwon sukari. ”