Masana kimiyya sun koyi juya kofi zuwa warkarwa ga masu ciwon sukari

Masana kimiyya daga Switzerland sun yi gwajin kimiyya akan mice. A baya can, masana sun gano kiba da nau'in ciwon sukari guda 2 a cikin jijiyoyin. A kan mice, masana sun gwada tasirin abubuwan da aka kirkiro sunadaran mai kunnawa, wanda ya fara yaƙar cutar sankara tare da kofi. A yayin binciken, masana kimiyya sun ba da kofi ga rodents har tsawon makonni biyu. Ya juya cewa cin maganin kafeyin a cikin mice ya rage yawan glucose a cikin jini. Bugu da ƙari, a cikin ƙirar gwaji yayin gwajin kimiyya, nauyin ya koma al'ada.

Masana kimiyyar Switzerland suna fatan cewa sakamakon binciken nasu zai inganta jiyya ga masu fama da cutar sankara.

Ciwon sukari mellitus cuta ce ta kullum. Babban mahimmancin ci gaban ciwon sukari shine tare da rashin isasshen ƙwayar cutar insulin. Insulin shine hormone wanda ke daidaita matakan sukari na jini.

Masana sun ce tare da mummunan yanayin cutar sankara, mutum na iya zama makaho. Hakanan, tare da wannan cutar, duk tasoshin jikin mutum yana tasiri. Kodan ta gaza, ciwan nama ba shi da kyau. Bugu da ƙari, tare da ciwon sukari mai ƙarfi, kafafu suna shafar kuma gangrene ya haɓaka. A cikin mawuyacin yanayi, an yanke wata gabar ga mai haƙuri.

Yawan masu ciwon sukari a Rasha na ci gaba da hauhawa duk shekara, duk da haɓaka ingantaccen tsarin rayuwa da shirye-shirye don magance cutar mai haɗari. Masanin ilimin abinci Veronika Denisikova ya gaya wa 360 yadda za a hana ci gaba da cuta mai haɗari ba tare da ƙoƙari ba.

Masana kimiyya sun koyi juya kofi zuwa warkarwa ga masu ciwon sukari

Masu binciken halittun Switzerland sun tsara yadda ake samun maganin kafeyin don rage glucose din jini. Sun ci gaba daga gaskiyar cewa ya kamata magunguna su zama masu araha, kuma kusan kowa yana shan kofi.

Tasirin kimiyya na kasa da kasa NatureCommunications ya wallafa bayanai game da binciken, wanda kwararrun daga makarantar fasaha ta Switzerland da ke Zurich suka yi. Sun gudanar da ƙirƙirar tsarin sunadarai na roba waɗanda suka fara aiki a ƙarƙashin rinjayar maganin kafeyin talakawa. Lokacin da aka kunna, suna haifar da jiki don samar da gluptagon-kamar peptide, abu wanda ke rage sukari jini. Designirƙirar waɗannan sunadarai, da ake kira C-STAR, ana shigar da su cikin jiki ta hanyar ƙwaƙwalwar ƙwayar cuta, wanda ke kunne lokacin da maganin kafeyin ke shiga cikin jiki. A saboda wannan, yawan maganin kafeyin da ke yawan fitowa cikin jinin mutum bayan shan kofi, shayi ko abin sha mai kuzari ya isa.

Ya zuwa yanzu, an gwada aikin C-STAR ne kawai akan mice tare da nau'in ciwon sukari na 2, wanda ya haifar da kiba da ƙarancin insulin. An sanya su cikin microcapsules tare da sunadarai, kuma bayan wannan sun sha kofi mai ƙarfi-zafin kofi da kuma sauran abubuwan sha. Don gwaninta, mun dauki samfuran kasuwanci na yau da kullun daga RedBull, Coca-Cola da StarBucks. Sakamakon haka, azumin glucose na jini mai sauri a cikin mice ya koma al'ada a cikin sati 2 kuma nauyin ya ragu.

Kwanan nan, ya zama sananne cewa maganin kafeyin yana da yawa yana rushewar hankalin jikin mutum ga insulin kuma hakan yana da wahalar daidaita matakan sukari na jini. Amma a gaban microimplants a cikin dabbobi, ba a lura da wannan tasirin ba.

Mutanen da ke da ciwon sukari suna buƙatar allura na yau da kullun na insulin. Wannan hanya ce mara dadi, kuma masana kimiyya suna kokarin fito da wanda zai maye gurbinsa. Masu binciken Switzerland sun fito da wata mafita: wani kwayar halitta mai narkewa wanda ke motsa samin insulin a cikin martani ga siyayyen kofi mai karfi.

Manufar "insulin masana'antu" ta shahara sosai tsakanin kwararrun masu ciwon sukari. Kowane irin wannan shine ƙwaƙwalwar gel wanda ya ƙunshi ɗaruruwan ɗakunan sel waɗanda ke asirce insulin cikin jini ko ƙarfafa abin da yake samarwa a cikin ƙwayar ƙwayar cuta. Harshen yana kare abubuwan da ke ciki daga tsarin rigakafi, amma yana ba da damar sunadarai su wuce ta.

Amma menene zai iya zama “farawa”, gami da aiki da ginin insulin? A cewar masana kimiyya daga Swiss Higher Technical School of Zurich, wani kofi mai sauƙi.

Sun kirkiro ƙwayoyin ɗan adam wanda aka ƙayyade matakin maganin kafeyin a cikin jini. Idan ya yi tsayi, kwayar ta fara samar da glucan-kamar peptide-1 (GLP-1), hormone dake motsa samarda insulin a cikin farji.

Idan aka sanya waɗannan sel cikin abin da aka sanya cikin ciki a cikin fata, mai haƙuri da ciwon sukari zai iya daidaita matakan sukari na jini tare da kopin kofi, shayi ko wani abin sha na maganin kafeyin. Ta hanyar daidaita ƙarfin abin sha, zaku iya samun ƙarin ragi ko G12 na ƙasa. Gwaje-gwaje a kan beraye tuni sun tabbatar da amfanin fasahar, in ji Guardian.

Developmentarshe na ƙarshe na na'urar da gwajin aikinsa na asibiti zai ɗauki shekaru goma. Koyaya, masana kimiyyar suna fatan cewa gano su a ƙarshe zai canza rayuwar mutane masu ciwon sukari. Kusan duk mutane suna shan shayi ko kofi, don haka zai yuwu a tsara matakin sukari a cikin jini ba tare da rabu da ayyukan yau da kullun ba.

Kimanin kofuna miliyan 1 na kofi suna shaye-shaye yau da kullun a duniya, amma har yanzu babu wanda ya san ko wane irin maganin kafeyin yafi dacewa. Masu binciken Amurkawa sun kirkiro wani tsari wanda zai amsa wannan tambaya. Dangane da bayanai kan ingancin bacci, yana bawa mai amfani shawarwarin duniya don shan kofi.

Masana kimiyya na Switzerland daga Jami'ar Zurich da Basel, haka kuma masu bincike na Faransa daga Jami'ar Fasaha sun gano cewa za a iya amfani da maganin kafeyin wajen maganin cutar siga.

An buga labarin tare da sakamakon binciken a cikin jaridar Nature Communication.

Masana kimiyya a zaman wani bangare na aikinsu na kimiyya sun kirkiro sel wadanda zasu iya asirin insulin don magance yawan maganin kafeyin a jiki. Kamar yadda aka nuna ta hanyar gwaje-gwajen kan mice, gabatarwar irin wannan sel yana taimakawa rage matakin glucose a cikin jini.

Masu binciken sun fayyace cewa sun haɗa ƙwayoyin ACaffVHH tare da manyan wuraren siginar siginar ciki, kuma an ƙirƙiri masu karɓa na roba da ake kira C-STAR. Su ne suka taimaka dangane da amfani da maganin kafeyin don haɓaka ayyukan ɗimbin kwayar halittar SEAP.

Dangane da sakamakon gwaje-gwajen da aka yi akan mice, ya juya ya nuna cewa ƙwayoyin maganin kafeyin suna nuna ƙananan matakan glucose na jini.

A farkon watan Yuni, masana kimiyya a jami’ar Heinrich Heine na Düsseldorf sun gano cewa yawan shan kofi na yau da kullun yana kare sel da tsarin jijiyoyin jini daga lalacewa.

Masu binciken halittun sun mayar da kofi zuwa warkarwa don kamuwa da cutar siga

Masanan halittu sun kirkiro sunadarai wadanda suke aiki a cikin sel ta hanyar kafeyin.

Don fara sarrafa kwayoyin halitta na roba da kuma "kunna" bayyanar kwayoyin halittun da ke kulawa da shi, ana buƙatar karamin kashi na maganin kafeyin, wanda aka samo a cikin kofi, shayi da abin sha mai ƙarfi, a cewar littafin NatureCommunications.

Masana kimiyya a cikin gwaji kan nau'ikan cututtukan cututtukan type 2 sun gano cewa yawan kofi yana rage matakan glucose a cikin mice tare da ƙwayoyin da aka dasa wanda ke samar da kwayoyin hoda a gaban maganin kafeyin.

Masana kimiyya: Matsi ya hade ƙarfe da oxygen tare da helium a tsakiyar Duniya

Masana kimiyya daga Jami'ar Fasaha ta Zurich sun koyi yadda ake amfani da maganin kafeyin a matsayin mai ƙira don samar da magungunan masu cutar sukari ga mara haƙuri. Istswararru sun kirkiro sunadarai masu aiki da ƙwayar cuta. Tsarin kwayoyin halitta mai kunnawa-abu ne wanda aka saka a cikin DNA na sel wadanda za'a saka su cikin farji.

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Tsarin da masana kimiyya suka kirkira shi ake kira C-STAR. An yi amfani da mice tare da microcapsules tare da sel waɗanda ke dauke da wannan tsarin. Sannan sati biyu dabbobi aka basu kofi. Sakamakon haka, matakin glucose a cikin jini ya zama al'ada a cikin ƙwayoyin jiyya kuma nauyin ya ragu.

Hoto: Daniel Bojar et al / Yanayin Sadarwa na 2018

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Masana kimiyya na Switzerland daga Jami'ar Zurich da Basel, haka kuma masu bincike na Faransa daga Jami'ar Fasaha sun gano cewa za a iya amfani da maganin kafeyin wajen maganin cutar siga.

An buga labarin tare da sakamakon binciken a cikin jaridar Nature Communication.

Masana kimiyya a zaman wani bangare na aikinsu na kimiyya sun kirkiro sel wadanda zasu iya asirin insulin don magance yawan maganin kafeyin a jiki. Kamar yadda aka nuna ta hanyar gwaje-gwajen kan mice, gabatarwar irin wannan sel yana taimakawa rage matakin glucose a cikin jini, ya rubuta iz.ru.

Masu binciken sun fayyace cewa sun haɗa ƙwayoyin ACaffVHH tare da manyan wuraren siginar siginar ciki, kuma an ƙirƙiri masu karɓa na roba da ake kira C-STAR. Su ne suka taimaka dangane da amfani da maganin kafeyin don haɓaka ayyukan ɗimbin kwayar halittar SEAP.

Dangane da sakamakon gwaje-gwajen da aka yi akan mice, ya juya ya nuna cewa ƙwayoyin maganin kafeyin suna nuna ƙananan matakan glucose na jini.

A farkon watan Yuni, masana kimiyya a jami’ar Heinrich Heine na Düsseldorf sun gano cewa yawan shan kofi na yau da kullun yana kare sel da tsarin jijiyoyin jini daga lalacewa.

Masu gwagwarmayar motsa jiki suna juyar da kofi zuwa wani magani na kamuwa da cutar siga

Masanan halittu masu haɓaka sunadaran sunadarai - ƙwaƙwalwar ƙwaƙwalwar ƙwayar ƙwayar ƙwaƙwalwa wanda ke aiki ta maganin kafeyin a cikin sel. Abubuwan da ke tattare da maganin kafeyin da ke cikin kofi, shayi, da abin sha mai ƙarfi sun isa su “kunna” irin wannan furotin kuma su fara bayanin kwayoyin halittar da ke sarrafa ta. An gwada aikin maganin maganin kafeyin da aka kirkira a aikace kan mice samfurin tare da ciwon sukari na 2. Amfani da kofi ya haifar da raguwar glucose a cikin mice tare da ciwon sukari da ƙwayoyin da aka sanya cikin ciki suna bayyana hormone na roba a gaban maganin kafeyin. An buga labarin a ciki YanayiSadarwa.

Caffeine yana cin abinci mai yawa a cikin duniya, don haka masana kimiyya suna ɗaukar wannan abu azaman mai rahusa kuma magani mai guba wanda za'a iya amfani dashi a aikace-aikace na likita daban-daban. Misali, masana kimiyya daga makarantar Sakandare ta Switzerland ta Zurich sun ba da shawarar amfani da maganin kafeyin a matsayin mai horarwa don haɓaka maganin mai cutar siga ga mai haƙuri. A saboda wannan, masana kimiyya sun haɓaka furotin mai kunnawa na mutum wanda ke amsa maganin kafeyin kuma yana kunshe da abubuwa masu yawa na aiki. Tsarin kwayar halitta wanda ke kunna mai kunnawa an saka shi ne a cikin DNA na sel wadanda za a iya shigar dasu a cikin pancreas.

Mai karɓar maganin kafeyin a cikin wannan tsarin shine anti anti-sarkar antibody wanda ya dace da ƙwayoyin guda ɗaya (wanda ya ƙare) a cikin martani ga maganin kafeyin a cikin ƙwayoyin micromolar. Yana cikin irin waɗannan kuzarin, alal misali, maganin kafeyin yana kasancewa a cikin jinin mutum bayan ya gama shaye-shaye dauke da shi.

Siffar farko ta mai sarrafawa ta roba dauke da maganin kafeyin, dauri da kuma jigilar jigilar halittu kuma an maida martani ga 100 micromoles na maganin kafeyin. Daga nan sai masu binciken suka “dinka” maganin maganin kafeyin don kare sunadaran da ke haifar da ɗayan siginar salula wanda ke haifar da farkon kwayar a lokaci ɗaya tare da ƙara yawan siginar sigina. A wannan yanayin, tsarin ya sake yin aiki a wani taro na 1 zuwa 0.01 micromoles na maganin kafeyin. Isarshe na ƙarshe na tsarin ana kiran shi C-STAR (maganin kafeyin da ke haɓakawa).

Makircin mai maganin kafeyin-wanda yake danne danne kere-kere. Yankin da ke kula da maganin kafeyin (aCaffVHH) yana raguwa a gaban maganin kafeyin kuma ana iya amfani dashi don kunna fassarar kai tsaye ko ƙara ƙarfin sigina

Daniel Bojar et al / Yanayin Sadarwa na 2018

Masana kimiyya na Switzerland daga Jami'ar Zurich da Basel, haka kuma masu bincike na Faransa daga Jami'ar Fasaha sun gano cewa za a iya amfani da maganin kafeyin wajen maganin cutar siga.

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Masana ilimin halittu daga Jami'ar Birmingham sun koyi yin hasashen yiwuwar raunin 'yan wasan ƙwallon ƙafa ta amfani da GPS da masu saukar sauri. Dangane da sabon binciken da aka buga a cikin Jaridar British Journal of Sports Medicine, motsa jiki mai yawa yana da alaƙa da haɗarin lalacewar kasusuwa da tsokoki na ƙafa. Lenta.ru

Masana kimiyya sun koya juya sel fata zuwa sel waɗanda ke samar da insulin

Masana kimiyyar halittar Amurka sun dauki muhimmin mataki a cikin haɓakar maganin farfadowa, lokacin da ƙwayoyin sel da kwayoyin suke girma ta amfani da fasaha na tantanin halitta. Sun juya sel fata na mutane zuwa sel beta na tsibirin na pancreatic na Langerhans, suna haɓaka insulin na hormone. banikx.ru

Masana kimiyya sun kira wata hanya don kawar da ciwon sukari ba tare da kwayoyi ba

Likitoci daga Kanada sun ba da hujjoji da yawa don yarda da gaskiyar cewa lokaci-lokaci na fama da yunwa na taimakawa wajen kawar da ciwon sukari na 2 da kuma dawo da tsarin aikin insulin na yau da kullun.

An gabatar da binciken nasu a Rahoton Kasuwanci na BMJ. “Ba mu taɓa ji cewa kwararrun masu halartar ba sun yi ƙoƙarin yin amfani da matsananciyar yunwa a matsayin magani ga masu ciwon sukari ba.

Nazarin da muke yi, ya nuna cewa hana abinci abinci lokaci ne mai inganci gaba daya har ma da kyawawan dabaru wanda zai baka damar shan insulin da kwayoyi, ”Suleiman Furmli na Jami'ar Toronto (Kanada) da abokan aikin sa.

A cewar ƙididdigar WHO, yanzu akwai mutane miliyan 347 da ke da ciwon sukari a cikin duniya, kuma kusan kowane 9 daga cikin masu ciwon sukari suna fama da ciwon sukari na 2, sakamakon karuwar garkuwar jiki zuwa insulin. Kashi 80% na masu ciwon sukari suna rayuwa ne a cikin ƙasashe masu karamin karfi da kuma na tsakiya.

A shekarar 2030, cutar sankarau zata zama abu na bakwai da ke haifar da mutuwa a duk duniya. Shekaru uku da suka gabata, masanan ilmin halitta na Burtaniya sun gano, suna gwaji tare da beraye, cewa ci gaban nau'in ciwon sukari na 2 yana da alaƙa da kiba a cikin ƙwayar hanta da hanta.

Cire dukkanin gram na kitse daga waɗannan gabobin, kamar yadda aka nuna ta hanyar ƙarin gwaje-gwajen, gaba ɗaya an kawar da duk alamun cutar, gami da haifar da sauran ƙwayoyin jikin zuwa "al'ada" tsinkayen kwayoyin. Daga baya sun nuna cewa ana iya samun sakamako iri ɗaya ta amfani da nau'in “azumi” - abinci na musamman wanda ke wanke ƙwayoyin hanji da hanta daga ƙiba mai yawa, kuma sunyi alƙawarin gabatar da sakamakon waɗannan gwaje-gwajen akan masu sa kai.

Furmley da abokan aiki nan da nan suka gabatar da misalai uku na yadda irin waɗannan "hanyoyin" suka taimaka wa masu ciwon sukari kawar da cutar, suna bayyana "labarun nasara" na marasa lafiya uku da ke zaune a Toronto kuma suka zo don ganin su.

Kusan kwanan nan, kamar yadda likitoci suka lura, maza uku masu shekaru 40 zuwa 70 wadanda suka sha wahala daga nau'ikan cututtukan type 2 masu ciwon sukari sun juya garesu. Dukkansu dole ne su dauki insulin, metformin da sauran magunguna waɗanda ke soke alamun cutar da inganta rayuwar marasa lafiya. Dukkanin marasa lafiya, a cewar Furmli, sun so su rabu da sauran alamomin mara kyau na masu ciwon sukari, amma ba sa son yin tiyata da sauran hanyoyin warkewa.

A saboda wannan dalili, likitocin sun gayyace su don shiga cikin gwajin kuma suna ƙoƙarin kawar da ciwon sukari ta hanyar yin azumi. Guda biyu daga cikinsu sun zaɓi ƙarin tsarin kulawa, masu ƙin abinci bayan kwana ɗaya, na uku na masu ciwon suga da ke fama da yunwa na kwana uku, daga nan suka fara cin abinci.

Sun bi cin abinci iri ɗaya na watanni 10, kuma masana kimiyya duk wannan lokacin suna ci gaba da kula da lafiyarsu da kuma canje-canje a cikin ƙwayoyin jikinsu.

Yayinda aka juya, duka hanyoyin guda ɗaya da sauran hanyoyin yin azumin suna da matukar amfani ga masu ciwon sukari. Bayan kusan wata guda, sun sami damar ƙin shan insulin da magungunan maganin cututtukan ƙwayar cuta, kuma matakin insulin da glucose a cikin jininsu ya ragu zuwa kusan matakan al'ada.

Godiya ga wannan, bayan 'yan watanni, dukkanin maza ukun sun sami damar rasa kusan 10-18%, kuma suna kawar da duk mummunan sakamako na ciwon sukari.

Kamar yadda likitoci suka jaddada, bayanan da aka tattara ta hanyar su yana nuna yiwuwar tasirin irin wannan maganin, amma baya tabbatar da cewa da gaske yana aiki a duk yanayin. Furmli da abokan aikinsa suna fatan wannan nasarar tasu zata karfafawa sauran masana kimiyya damar fara “gwaji” gwaji na asibiti wanda ya shafi karin masu taimako.

1. 
   Ametov A.S. Granovskaya-Tsvetkova A.M., Kazey N.S. Non-insulin-dogara da ciwon sukari mellitus: kayan yau da kullum na pathogenesis da far. Moscow, Cibiyar Nazarin Lafiya ta Rasha na Ma'aikatar Lafiya na ofungiyar Rasha, 1995, shafuka 64, ba a kayyade su ba.
2. 
   M. Akhmanov “Ciwon sukari ba magana ba ce. Game da rayuwa, makoma da begen masu ciwon sukari. ” St. Petersburg, gidan wallafe-wallafen "Nevsky Prospekt", 2003
3. 
   Zakharov Yu.L., Korsun V.F. Ciwon sukari Moscow, Gidan wallafa ofungiyar Unungiyoyin “ungiyoyin “Garnov”, 2002, shafuka 506, bazuwar kwafin 5000.

Bari in gabatar da kaina. Sunana Elena. Na kasance ina aiki a matsayin endocrinologist fiye da shekaru 10. Na yi imanin cewa a halin yanzu ni ƙwararre ne a fagen aikina kuma ina so in taimaka wa duk baƙi zuwa shafin don warware matsalolin da ba ayyuka sosai ba. Duk kayan don rukunin yanar gizon an tattara su kuma ana aiwatar dasu da kyau don isar da sanarwa gwargwadon iko. Kafin amfani da abin da aka bayyana akan gidan yanar gizon, tattaunawa mai mahimmanci tare da kwararru koyaushe wajibi ne.