Latren Pentoxifylline

Latren magani ne wanda ke inganta microcirculation da rheological Properties na jini. Abubuwan da ke aiki na shirye-shiryen Latren shine pentoxifylline, wanda ke magana da ƙarshen vasodilali na ƙungiyar purine. Latren yana kawar da jijiyoyin jiki na santsi na jijiyoyin jini, bronchi da sauran gabobin ciki. Magungunan yana hana phosphodiesterase, inganta halayen rheological na jini da microcirculation, yana taimakawa haɓaka abun ciki na cyclic 3,5-AMP a cikin jijiyoyin jijiyoyin jiki mai santsi da ƙwayoyin platelet. Lokacin amfani da Latren, akwai karuwa a cikin abubuwan ATP a cikin sel jini da karuwa a cikin ƙarfin ƙwayoyin sel. Latren yana taimaka wajan shakata daɗaɗaɗɗen ƙwayar tsoka mai sanyin jijiyoyin jini, rage jimlar ƙarfin jijiyoyin jijiyoyin jini (ba tare da wani canji mai yawa a cikin zuciya ba), kazalika da ƙara minti da ƙarar jini na systolic.

Latren yana da tasirin antianginal, wanda aka samu ta hanyar shakatawa da sanyin jiki na jijiya jijiyoyin zuciya.
Magungunan yana inganta jijiyar oxygen a cikin jini, yana fadada tasoshin huhu, sautunan jijiyoyin jiki (diaphragm da tsokoki na ciki), yana haɓaka zirga zirgar jini (zagaye) zagaye jini kuma yana ƙaruwa da yawaitar jini yana gudana zuwa gabobin da kyallen takarda.
Latren yana da tasiri mai amfani a cikin ayyukan bioelectric na tsarin juyayi na tsakiya kuma yana taimakawa haɓaka abubuwan ATP a cikin ƙwayoyin kwakwalwa.
Yin aiki a kan kaddarorin jikin membrane na sel jini, Latren yana haɓaka haɓakawarsu. Yana haifar da rarrabuwa a platelet kuma yana rage danko jini.

Sakamakon yaduwar hawan jini, kananan halittun jini a cikin yankin ischemic suna inganta.
Tare da yin magana da tsinkaye (zahirin rauni a cikin jijiyoyin mahaifa), pentoxifylline yana tsawaita hanyar tafiya, yana kawar da jijiyoyin wuya na maraƙin kuma yana hana bayyanar jin zafi a hutawa.
Magungunan yana metabolized kusan gabaɗaya, yana samar da metabolites 5, gami da magunguna masu aiki. Pentoxifylline an cire shi ta hanyar kodan ta hanyar metabolites. Rabin rayuwar pentoxifylline da metabolites shine kusan awanni 0.5-1.5. Kasancewar nakuda mai aiki ko aikin hepatic na iya haifar da karuwa a cikin rabin rayuwa.

Alamu don amfani

An wajabta magungunan Latren don cututtukan wurare dabam dabam, rikicewar cututtukan zuciya, rarrabuwar kai, cuta da cutar Raynaud, suna kashe endarteritis.
Hakanan ana amfani da miyagun ƙwayoyi Latren don keta ƙwaya trophic nama.
Ana iya tsara magungunan a cikin hadadden kulawa da marasa lafiya da ke fama da cututtukan varicose, cututtukan post-thrombotic syndrome, gangrene, frostbite da trophic ulcers.

An wajabta Latren don marasa lafiya da haɗarin cerebrovascular, bugun jini na ischemic, encephalopathy dyscirculatory, da kuma arteriosclerosis na cerebral, wanda ke tare da ciwon kai, tsananin farin ciki, bacci da raunin ƙwaƙwalwar ajiya.
Bugu da kari, ana amfani da Latren wajen maganin rikicewar jijiyoyin jiki a cikin choroid da retina, da kuma a cikin canje-canjen degenerative tare da raunin hankali a hankali sakamakon lalacewar jijiyoyin jijiya na ciki.

Hanyar aikace-aikace

Latren miyagun ƙwayoyi an yi shi ne don gudanarwar jijiya. An saita sashi ne ta hanyar likita daban-daban kuma ana lasafta shi cikin la'akari da nauyin jikin mai haƙuri, ƙayyadadden cuta na wurare dabam dabam, cututtukan haɗuwa da juriya ga warkewa.

Ga tsofaffi da yara sama da shekara 12, ana bada shawarar aikace-aikacen regimens na gaba don gudanarwar jijiyoyin jini:
Abunda ke cikin murfin vil 200 (100 MG na pentoxifylline) ana gudanar da shi ta hanyar ciki sau 90 minti 90-180.
Tare da haƙuri mai kyau, yana yiwuwa a ƙara kashi tare da gudanarwar jet zuwa 200-300 MG (wanda ya dace da 400-500 ml na bayani).
Matsakaicin tsawon lokacin aikin jiyya, a matsayin mai mulkin, shine kwanaki 5-7 kuma ya dogara da kuzarin cutar. Nan gaba, za a iya tura mai haƙuri zuwa nau'in pentoxifylline na bakin.
Matsakaicin adadin yau da kullun shine 300 MG.

An ba shi izinin amfani da maganin don maganin yara a ƙarƙashin shekara 12 da jarirai. A irin waɗannan halayen, ana lissafin kashi gwargwadon nauyin jikin mutum. Ga yara 'yan kasa da shekaru 12, a matsayin mai mulkin, an wajabta Latren a cikin kashi ɗaya na 5 MG (10 ml Latren bayani) a 1 kg na nauyin jiki.

Side effects

Lokacin amfani da Latren a cikin marasa lafiya, ci gaban irin wannan illa mara amfani saboda pentoxifylline mai yiwuwa ne:
Daga tsarin juyayi: hargitsi na bacci, ciwon kai, farin ciki, damuwa, mara damuwa. A cikin lokuta daban, an lura da ci gaban cututtukan ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta.
A wani bangare na tsarin hematopoietic, zuciya da jijiyoyin jini: hyperemia na fata na fuska da babba na jiki, edema, angina pectoris, arrhythmia, tachycardia, cardialgia, hypotension art, leukopenia, thrombocytopenia, pancytopenia.

Daga tsarin hepatobiliary da narkewa mai narkewa: atony na ciki, tashin zuciya, amai, anorexia, cholestatic hepatitis, haɓaka cholecystitis, haɓaka ayyukan hanta enzymes.
Sauran: hematomas, zub da jini na ciki, rage ƙarancin gani na gani, ƙaruwar ƙoshin ƙusa.
Allergic halayen: hyperemia na fata, itching, urticaria, anaphylactic shock, angioedema.

Contraindications

Ba a wajabta Latren ga marasa lafiya tare da sananniyar rashin hankali ga kowane daga cikin abubuwan da ke cikin miyagun ƙwayoyi, har ma da abubuwan da aka samo na xanthine.
Bai kamata a yi amfani da Latren don lura da marasa lafiya da ke fama da matsanancin ƙwaƙwalwar ƙwayar myocardial infarction, porphyria, hemorrhage na baya, bugun jini, ƙararraki na hanji ko na jijiyoyin ƙwayar cuta da na zuciya.
Ba a yin amfani da Latren don kula da marasa lafiya da ke fama da arrhythmia, rashin lafiyar jijiya mara jijiyoyi, ƙoshin koda ko rashin lafiyar hepatic, da kuma marasa lafiya da yawan zubar jini.

Ya kamata a lura da hankali lokacin da ake rubuta Latren ga marasa lafiya da ciwon sukari mellitus, gazawar zuciya, kumburin ciki na ciki ko duodenum, da kuma marassa lafiyar marasa lafiya.
Ya kamata a lura da hankali lokacin da ake rubuta Latren ga marasa lafiya da aka yiwa tiyata (a kodayaushe sanya idanu na haemoglobin da jinin haila dole ne).

Hulɗa da ƙwayoyi

Shan sigari yana rage tasirin magani na pentoxifylline.
Magungunan Latren tare da amfani da haɗe zasu iya haɓaka tasirin magungunan anticoagulants kai tsaye da kuma kai tsaye da ma'aikatan thrombolytic. Ana amfani da haɗuwa da waɗannan magunguna tare da kulawa da kullun akan tsarin coagulation na jini.
Latren tare da amfani na lokaci daya yana haɓaka aikin maganin rigakafin cutar cephalosporin.
Pentoxifylline, lokacin amfani dashi tare, yana inganta sakamakon valproic acid, magungunan antihypertensive, wakilai na bakin jini da insulin.

Yawan pentoxifylline a cikin jini yana ƙaruwa tare da amfani da shi tare da cimetidine.
Haɗewar yin amfani da miyagun ƙwayoyi Latren da wasu magungunan xanthine na asali na iya haifar da haɓakar ƙwayoyin tsotsa.

Yawan abin sama da ya kamata

Lokacin amfani da allurai da yawa na pentoxifylline a cikin marasa lafiya, jijiyoyi, rauni, rauni, jijiya, amai, ko tashin hankali na iya haɓaka. Bugu da ƙari, tare da ci gaba da karuwa a cikin adadin Latren, marasa lafiya sun lura da ci gaban tachycardia, hauhawar jini, asarar ƙwaƙwalwar ƙwayar cuta, ƙwayar cuta, gastrointestinal, da tashin hankali.

Babu takamaiman maganin rigakafi. Game da yawan abin sama da ya kamata, bayarda maganin warkarwa da nufin kawar da alamun maye a tare da pentoxifylline.
Ya kamata a gudanar da aikin kwantar da hankali a cikin asibiti a karkashin kulawar ma’aikatan lafiya koyaushe.

Form sashi

Magani jiko 0.5 MG / ml

1 ml na miyagun ƙwayoyi ya ƙunshi

abu mai aiki - kashi 0,5 mg,

karin taimakoabu: sodium chloride, potassium chloride, alli chloride, sodium lactate, ruwa don yin allura.

M ruwa mai haske ko rawaya mai launin rawaya mai haske.

Kayan magunguna

Pharmacokinetics

Babban ma'aunin magunguna 1- (5-hydroxyhexyl) -3,7-dimethylxanthine (metabolite I) an ƙaddara shi a cikin ƙwayar plasma a cikin taro wanda ya wuce 2 sau da yawa daga abubuwan da ba su canzawa ba kuma yana cikin yanayin jujjuyar ma'aunin ƙwaƙwalwar ƙwayoyi tare da shi. A wannan batun, pentoxifylline da metabolite yakamata a yi la'akari dasu azaman aiki gabadaya. Rabin rayuwar pentoxifylline shine 1.6 hours.

Pentoxifylline gaba daya metabolized ne; fiye da kashi 90% daga cikin kodan an keɓance shi ta hanyar rashin aiki, ruwa mai narkewa mai ruwa-ruwa. Kasa da 4% na maganin da ake gudanarwa an keɓance shi a cikin feces. A cikin marasa lafiya da rauni mai girma na koda, hanjin metabolites ya ragu sosai. A cikin marasa lafiya da ke fama da aikin hanta, an lura da karuwa a cikin rabin rayuwar pentoxifylline.

Pharmacodynamics

Pentoxifylline asalin asalin methylxanthine ne. Hanyar aiwatar da pentoxifylline yana da alaƙa da hanawar phosphodiesterase da tarawar 3,5-AMP a cikin jijiyoyin jijiyoyin jiki mai santsi, ƙwayoyin jini, da kuma a cikin wasu ƙwayoyin cuta da gabobin. Pentoxifylline yana hana haɗarin platelet da ƙwayoyin jini, yana ƙaruwa da sassauci, yana rage haɓakar fibrinogen a cikin ƙwayar jini da haɓaka fibrinolysis, wanda ke rage ɓatar da jini da inganta halayen rheological. Bugu da kari, pentoxifylline yana da rauni mai rauni na myotropic vasodilator, dan kadan yana rage juriya na gaba daya yana da tasiri inotropic. Sakamakon amfani da pentoxifylline, microcirculation da wadatar oxygen zuwa kyallen suna inganta, mafi yawan duka a cikin gabar jiki, tsarin juyayi na tsakiya, da kuma matsakaici a cikin kodan. A magani dan kadan dilates da na jijiyoyin zuciya.

Formaddamar da tsari da abun da ke ciki

Ana amfani da miyagun ƙwayoyi a cikin sigogin masu zuwa:

• Magani don gudanarwar ciki da jijiyoyin bugun gini: ruwa mai bayyana, maras launi ko mara launi (2 ml ko 4 ml a cikin ampoules, a cikin kunshin kwayar PVC (polyvinyl chloride) fim na 1, 2 ko 5 ampoules, kunshin sel a cikin kwali mai kara),
• Allunan mai rufi: harsashi mai rawaya (guda 10 kowannensu a cikin fakitin bakin ciki, 1 fakitin a cikin kwali na kwali).

A cikin 1 ml na bayani ya ƙunshi:

• Abubuwan da ke aiki: ondansetron hydrochloride dihydrate (dangane da ondansetron) - 2 MG,
• Abubuwan taimako: hydrochloric acid, sodium chloride, ruwa don allura.

1 kwamfutar hannu mai rufi ya ƙunshi:

• Abubuwan da ke aiki: ondansetron hydrochloride dihydrate (cikin sharuddan ondansetron) - 4 MG,
• Abubuwan taimako: Aerosil (sillofon silicon dioxide), cellulose microcrystalline, sittin magnesium, sitacin dankalin turawa,
• Harsashi: hydroxypropyl cellulose (hyprolose), tropeolin O, polysorbate (tween-80), castor oil.

Ciki

Babu isasshen gogewa game da amfani da miyagun ƙwayoyi a cikin mata masu juna biyu.
Saboda haka nada Latren lokacin ba da shawarar ba da shawarar.
Pentoxifylline a cikin adadi kaɗan ya wuce zuwa cikin madara. Idan an yi mata magani tare da Latren, dole ne a daina shayar da jarirai.

Yin hulɗa tare da wasu kwayoyi

Latren na iya inganta tasirin magungunan da ke shafar tsarin coagulation na jini (kai tsaye da kuma magungunan anticoagulants, kai tsaye). Yana haɓaka tasirin ƙwayar cuta cephalosporins (cefamandol, cefoperazone, cefotetan) ta hanyar inganta shigar azurar rigakafin ƙwayoyin cuta a cikin nama ta hanyar ƙara yawan tashin jini na jijiyoyin jini. Yana haɓaka aikin valproic acid. Theara tasirin magungunan antihypertensive, insulin da magungunan hypoglycemic na baki. Cimetidine yana ƙara maida hankali ga Latren a cikin jini na plasma, yana haifar da haɗarin haɗarin sakamako masu illa.
Haɗewar yin amfani da miyagun ƙwayoyi tare da wasu ƙayyadaddun magunguna na xanthine na iya haifar da damuwa ga damuwa.

Mu'amala da Lafiya

Ana iya inganta tasirin rage yawan sukari na jini zuwa insulin ko na maganin antidi mai narkewa. Sabili da haka, ya kamata a kula da marasa lafiya waɗanda suke karɓar magani don ciwon sukari.

A cikin lokacin cinikin bayan-bayan, an ba da rahoton karar aikin anticoagulant a cikin marasa lafiya lokaci guda tare da pentoxifylline da antivitamins K. Lokacin da aka tsara sashi na pentoxifylline ko an canza shi, ana bada shawara don saka idanu akan aikin anticoagulant a cikin wannan rukuni na marasa lafiya. Pentoxifylline na iya haɓaka tasirin sakamako na magungunan antihypertensive da sauran magunguna waɗanda zasu iya haifar da raguwar hauhawar jini. Yin amfani da pentoxifylline da theophylline a lokaci guda a cikin wasu marasa lafiya na iya haifar da karuwa a cikin matakan theophylline a cikin jini. Sabili da haka, yana yiwuwa a ƙara yawan tasirin da kuma ƙara alamun bayyanar da illa ta theophylline.

Rashin daidaituwa.Kada a cakuda miyagun ƙwayoyi tare da wasu kwayoyi a cikin akwati ɗaya.

Umarni na musamman

A alamun farko na amsawar anaphylactic / anaphylactoid, dole ne a dakatar da maganin nan da nan kuma a nemi likita. Game da amfani da miyagun ƙwayoyi, marasa lafiya da raunin zuciya ya kamata su fara isa ga matakin biyan diyya na jini.

A cikin marasa lafiya da masu ciwon sukari mellitus da karɓar magani tare da insulin ko na maganin antidiabetic, lokacin amfani da magunguna masu yawa, yana yiwuwa a ƙara tasirin waɗannan kwayoyi akan sukarin jini (duba sashin "Abubuwan Cutar Magunguna"). A cikin waɗannan halayen, ya kamata a rage yawan insulin ko wakilin maganin antidiabetic, kuma ya kamata a kula da haƙuri a hankali. Marasa lafiya tare da tsarin lupus erythematosus (SLE) ko tare da wasu cututtukan cututtukan haɗin haɗin haɗin za a iya tsara su ta pentoxifylline kawai bayan yin cikakken nazarin yiwuwar haɗari da fa'idodi. Tunda akwai haɗarin haɓakar ƙosasshen ƙwayar cuta ta aplastic yayin jiyya tare da pentoxifylline, saka idanu na yau da kullun na ƙididdigar jini ya zama dole.

A cikin marasa lafiya da gazawar renal (keɓantar da keɓaɓɓen ƙasa da 30 ml / min) ko lalatawar hanta mai ƙarfi, ana iya jinkirta fitarwar pentoxifylline. Ana buƙatar saka idanu sosai.

Musamman lura sosai wajibi ne don:

- marasa lafiya da mummunan cututtukan zuciya,

- marasa lafiya da infarction na myocardial,

- marasa lafiya masu fama da jijiya,

- marasa lafiya da mummunan atherosclerosis na kwakwalwa da jijiyoyin jini, musamman tare da hauhawar jini na jijiya da jijiyoyin zuciya. A cikin waɗannan marasa lafiya, lokacin ɗaukar ƙwayoyi, hare-hare na angina pectoris, arrhythmias da hauhawar jijiya mai yiwuwa ne,

- marasa lafiya tare da gazawar renal (ƙaddamar da creatinine a ƙasa 30 ml / min),

- marasa lafiya da gazawar hanta mai yawa,

- marasa lafiya da ke da muradin zub da jini, ya haifar, alal misali, ta hanyar jiyya tare da cututtukan ƙwaƙwalwar ƙwayar cuta ko rikicewar ƙwayar jini. Game da zub da jini - duba sashin "Contraindications",

- marasa lafiya waɗanda raguwa a cikin jini shine babban haɗari (alal misali, marasa lafiya da mummunan cututtukan cututtukan zuciya da jijiyoyin bugun jini wanda ke ba da jini ga kwakwalwa),

- marasa lafiya waɗanda ke karɓar magani tare lokaci guda tare da pentoxifylline da sinadaran bitamin K (duba ɓangaren "Abubuwan Cutar Drug"),

- marasa lafiya waɗanda ke karɓar magani a lokaci guda tare da pentoxifylline da wakilai na maganin cututtukan ƙwayar cuta (duba sashin "Abubuwan Cutar Lafiya").

Yi amfani da lokacin daukar ciki ko lactation. A lokacin daukar ciki da lactation, da amfani da miyagun ƙwayoyi ne contraindicated.

Yara. Babu kwarewa game da amfani da miyagun ƙwayoyi a cikin yara.

Siffofin tasiri na miyagun ƙwayoyi akan ƙarfin tuka abin hawa ko wasu hanyoyin haɗari

Tunda ana amfani da miyagun ƙwayoyi a asibiti, babu bayanai game da irin wannan tasirin.