Yadda za a yi amfani da miyagun ƙwayoyi Glyurenorm?

Pharmacodynamics Glurenorm shine wakili mai narkewa a cikin jini, wanda ya samo asali daga ƙarni na biyu. Glurenorm yana ƙarfafa ɓoyewar ƙwayar insulin ta hanyar β-sel, yana inganta yin amfani da glucose, yana hana aiwatar da lipolysis.
Glurenorm yana rage juriya na insulin a cikin hanta da kyallen takaddar tso adi ta hanyar kara yawan masu karɓar insulin da kuma haɓaka hanyoyin karɓar post-receptor saboda aikin insulin. Tabbataccen abu don aikin hypoglycemic na Glyurenorm shine kasancewar insulin halittar jini.
Sakamakon rage yawan matakan glucose na jini yana farawa a minti 60 zuwa 90 bayan gudanar da maganin baka kuma ya kai aƙalla sa'o'i 2-3 bayan gudanarwa.
Tsawon lokacin sakamako na hypoglycemic na Glurenorm shine sa'o'i 8-10. Sabili da haka, ana daukar Glurenorm magani ne mai ɗan gajeren lokaci.
Yin amfani da sulfonylureas, waɗanda ke da magungunan gajerun hanyoyin, ana bada shawarar don kula da marasa lafiya tare da haɗarin hauhawar jini, alal misali, tsofaffi marasa lafiya da marasa lafiya da gazawar renal.
Tun da kawar da dan adam na Glyurenorm ne sakaci, da miyagun ƙwayoyi za a iya wajabta shi musamman ga marasa lafiya da na koda ko gazawar ne mai ciwon sukari nephropathy.
An tabbatar da inganci da amincin amfani da Glyurenorm a cikin marasa lafiya da masu ciwon sukari, wanda aka nuna don maganin tare da shirye-shiryen sulfonylurea waɗanda ke da cututtukan hanta.
Pharmacokinetics Makonni 2-3 bayan shigo da 30 MG na Glurenorm, an kai mafi girman yawan aikin plasma (500-700 ng / ml), sai a rage raguwa 2 a cikin awa 1 / 2-1. Kwatanta kwalliyar kwalliya a cikin jini yana tabbatar da kusan cikakkiyar sha. da miyagun ƙwayoyi.
Glurenorm yana aiki tare da kariyar plasma (99%).
Glurenorm yana hadewa gaba daya, akasari ta hanyar samar da ruwa da tsafta ne. Yawancin metabolites suna keɓe ta cikin tsarin biliary tare da feces. Kawai karamin kashi na metabolites ne da kodan ke fitar da su. Kawai 5% na metabolized kashi ana gano cikin fitsari. Ko bayan maimaita akai-akai na Glyrenorm ana amfani da su, ƙarar renal ya rage kaɗan.
Bugu da kari, tare da gudanarwa na yau da kullun na Glyrenorm ga marasa lafiya da ke fama da cutar sankarar mahaifa tare da gazawar koda, ba a gano canje-canje a hanyar shakatawa ba. Babu wani haɗarin tarawar abu ko abubuwan gina jiki.
Metabolites jini ba su da magani kuma ba ya shafar matakan glucose na jini.
Gwajewar magunguna da aka yi akan beraye da beraye sun nuna cewa Glyrenorm da metabolites ɗin ba su ƙetare BBB ba ko kuma shinge.

Yin amfani da miyagun ƙwayoyi Glyurenorm

Farkon maganin
Yawanci, kashi na farko na Glenrenorm shine 1/2 kwamfutar hannu (15 mg). Ana ɗaukar shi lokacin karin kumallo. Tare da rashin aiki, ana iya ƙara yawan kashi a hankali. Bayarda cewa ba a rubuto allunan 2 sama da (60 MG) ba, ana iya shan Glyurenorm na yau da kullun yayin karin kumallo. Koyaya, lokacin amfani dashi a cikin allurai mafi girma, ana samar da mafi kyawun iko ta hanyar sau 2-3 a kowace rana. A wannan yanayin, mafi yawan adadin ya kamata a sha a lokacin karin kumallo. Dole ne a dauki allunan glenrenorm a farkon cin abinci. Ya kamata a sani cewa kara yawan zuwa allunan 4 (120 MG) a rana akasari ba ya haifar da ƙarin ƙaruwa a cikin warkewar cutar.
Lokacin maye gurbin wani wakili na maganin hypoglycemic wakili tare da irin wannan aikin aikin
An ƙaddara matakin farko dangane da cutar a lokacin gudanar da magani. Lokacin maye gurbin wani wakilin antidiabetic tare da Glurenorm, ya kamata a tuna cewa aikin 1 kwamfutar hannu na Glurenorm yana daidai da 1000 mg na tolbutamide.
Hada magani
Idan monotherapy tare da Glurenorm ba ya samar da isasshen iko na matakan glucose na jini, ƙarin ƙarin ganawar biguanide ya kamata a yi la'akari.
Tsawon lokacin karatun ya dogara da yanayin cutar da kuma tasiri na maganin.

Contraindications zuwa yin amfani da miyagun ƙwayoyi Glurenorm

Wani nau'in insulin-dogara da ciwon sukari mellitus, ciwon sukari da precomatosis, ciwon sukari mellitus rikitarwa ta hanyar acidosis da ketosis, bayan kamanceceniya na pancreatic, a cikin lokacin mummunan cuta mai kamuwa da cuta, kafin tiyata, mummunan lalata hanta, mummunar cutar hanta (hepatic) porphyria, maganin rashin hankali ga shirye-shiryen sulfonylurea.

Side effects na miyagun ƙwayoyi Glenrenorm

A matsayinka na mai mulki, Glurenorm yana da haƙuri da haƙuri, amma a wasu lokuta maganganun hypoglycemic, tashin zuciya, amai, maƙarƙashiya, zawo, asarar abinci, halayen rashin lafiyan: itching, eczema, ciwon kai, tsananin farin ciki, tashin hankali na masauki, thrombocytopenia na iya faruwa.
A wasu halayen, intrahepatic cholestasis, urticaria, Stevens-Johnson syndrome, leukopenia, agranulocytosis na iya haɓaka.

Umarnin na musamman don amfanin Glurenorm na miyagun ƙwayoyi

Lokacin daukar ciki da lactation. Nazarin amfani da Glyurenorm a lokacin daukar ciki da lactation ba a gudanar da shi ba. Saboda haka, ya kamata a guji amfani da Glurenorm yayin wannan lokacin. Idan an kafa ciki, ya zama dole a daina shan Glyurenorm da wuri-wuri.
A cikin lura da ciwon sukari, kula da lafiya na yau da kullun ya zama dole. Ya kamata a kula musamman a lokacin zaɓin kashi ko maye gurbin magani.
Kodayake kawai 5% na Glurenorm ne ke raba shi da kodan kuma yawanci ana jure shi a cikin marasa lafiya da ke fama da cutar koda, ya kamata a gudanar da aikin kula da marasa lafiyar da ke fama da cutar koda a cikin kulawa ta kusa da likita.
Marasa lafiya da ciwon sukari suna iya haifar da ci gaban cututtukan zuciya. Wannan haɗarin zai iya rage kawai ta bin ingantaccen abincin da likita ya umarta. Yin amfani da wakilai na maganin rigakafi na baka bai kamata ya maye gurbin abincin da yake warkewa wanda zai ba ku damar sarrafa nauyin jikin mai haƙuri kuma yana da sharadi ko da kuwa amfani da ƙwayar maganin cututtukan jini. Dukkanin wakilai na maganin antidiabetic tare da abinci wanda ba a iya amfani dashi ba ko kuma tare da cin zarafin tsarin shaye shayen na iya haifar da raguwa sosai a matakan glucose na jini. Yin amfani da sukari, Sweets, ko abin sha mai yawanci yana taimakawa hana farawar yanayin hailala.
Tasiri a kan ikon tuka motoci da aiki tare da sauran hanyoyin.Yakamata a gargadi marassa lafiya game da bin ka'idodi don hana baracewar jini yayin tuki. Wannan yana da mahimmanci musamman ga waɗanda basu da alamun cututtukan hypoglycemia ko gano abubuwa akai-akai na cututtukan jini. Yakamata yakamata ayi la'akari da dacewar tuki yayin da wadannan yanayi suke.

Mu'amala da Magunguna Glurenorm

Dole ne a yi cudanya da magungunan da ke shafar metabolism metabolism.
Magungunan da za su iya inganta tasirin hypoglycemic na Glurenorm: NSAIDs, MAO inhibitors, oxytetracyclines, ACE inhibitors, clofibrates, cyclophosphamides da abubuwan da suka samo asali, sulfonamides da sauran maganin rigakafin da ke hana haɓakawa, sauran magungunan antidiabetic, insulin.
Magungunan da za su iya inganta tasirin hypoglycemic na Glurenorm: β-adrenergic recepor blockers, wasu masu juyayi (misali, clonidine), reserpine, guanethidine. Wadannan abubuwa kuma suna iya rufe alamun bayyanar cututtukan jini.
Magungunan da za su iya rage tasirin hypoglycemic na Glurenorm: GCS, hanawar steroid, juyayi, hodar iblis, da glucagon, diuretics (nau'in thiazide ko madauki diuretics), diazoxide, phenothiazine, acid nicotinic.
Barbiturates, rifampicin, phenytoin da makamantansu zasu iya rage zafin cutar tasirin glyrenorm ta hanyar karfafa tsokar enzymes.
An lura da raguwa ko karuwa a cikin tsananin tasirin tasirin cutar Glurenorm tare da amfani da lokaci ɗaya tare da antagonists na masu karɓar H2 (cimetidine, ranitidine) da barasa.

Formaddamar da tsari da abun da ke ciki

Siffar sashi na Glyurenorm shine allunan: zagaye, laushi, fari, tare da yanke gefuna, a gefe guda akwai alamar tambarin kamfanin, a gefe guda akwai haɗari, a garesu akwai alamar “57C” (pcs 10. A cikin blisters, 3, 6 ko Blister 12 a cikin fakitin kwali).

Abincin mai aiki: glycidone, a cikin kwamfutar hannu 1 - 30 MG.

Substancesarin abubuwa: sitaci masara mai narkewa, sitaci masara mai bushe, magnesium stearate, lactose monohydrate.

Pharmacodynamics

Glycvidone yana haɓaka aikin insulin ta hanyar kunna hanyar glucose-hanyar matsakaici don samar da wannan abu. Gwajin dabbobi sun tabbatar da cewa miyagun ƙwayoyi suna rage juriya ga insulin a cikin tsopose nama da ƙwayar hanta ta hanyar haɓaka kusancin masu karɓar insulin, kazalika da karfafa hanyar mai karɓa ta insulin. Tasirin hypoglycemic yana haɓaka sa'o'i 1.5 bayan aikin maganin. Ana amfani da mafi girman tasirin sa'o'i 2-3 bayan gudanarwa kuma ya kai tsawon awanni 8-10. Glycvidone shine mai takaitaccen abu wanda ake amfani da shi wanda ke haifar da maganin karancin jini, wanda ke haifar da amfani da shi a cikin marasa lafiya da ke dauke da cutar sankara mai nau'in 2 tare da hadarin hauhawar jini, alal misali, a cikin tsofaffi marassa lafiya ko marasa lafiya da ke fama da tabin hankali.

Tunda glycidone an keɓance ta cikin kodan a cikin adadi kaɗan, ana iya ba da magani ga marasa lafiya da ke fama da ciwon sukari da kuma rauni na aikin koda. Akwai wata shaidar cewa shan Glenrenorm a cikin marasa lafiya da ke dauke da cutar sankara mai nau'in 2, masu fama da cututtukan hanta, yana da inganci kuma mai lafiya. Koyaya, cirewar abu mai karfi a cikin irin wannan mara lafiyar an hana ta. A wannan yanayin, ƙaddamar da glycidone a cikin marasa lafiya da ciwon sukari mellitus wanda ke rikitarwa ta hanyar raguwar hepatic mai ƙarfi ba da shawarar ba.

Sakamakon bincike na asibiti ya tabbatar da cewa yin amfani da Glyurenorm na watanni 18 da watanni 30 ba ya haifar da ƙaruwa a cikin nauyin jikin mutum, kuma a wasu yanayi ma akwai raguwar nauyin jiki ta 1-2 kilogiram. Nazarin kwatankwacin abin da aka yi nazarin sauran tsararren maganin sulfonylurea ya tabbatar da kasancewar manyan canje-canje a cikin nauyin jiki a cikin marasa lafiya suna shan glycidone.

Pharmacokinetics

Tare da ɗayan guda ɗaya na glycidone a kashi 15 ko 30 MG, ana amfani da sinadarin daga narkewa tare da babban gudu kuma kusan gaba ɗaya (80-95%). Matsakaicin mafi girman yawan jini a cikin jini shine 0.65 μg / ml (ya bambanta a cikin kewayon daga 0.12 zuwa 2.14 μg / ml) kuma an kai shi a cikin awanni 2 zuwa mintina 15 (hawa sauƙaƙa a cikin kewayon 1.25-4.75 yana yiwuwa awanni). Yankin da ke ƙarƙashin tsarin lokacin maida hankali (AUC) shine 5.1 μg × h / ml (sauyawa tsakanin 1.5 da 10.1 .1g × h / ml mai yiwuwa ne).

Babu bambance-bambance a cikin ma'aunin magunguna tsakanin daidaikun mutane masu lafiya da marasa lafiya da masu ciwon sukari mellitus.

Glycvidone yana da alaƙa da kyakkyawar dangantaka don sunadaran plasma fiye da kashi 99%. Ba a rasa bayani game da shigarwar abu ba ko kuma abubuwan haɓaka ta hanyar ƙwaƙwalwar jini da jijiyoyin jini. Babu wata shaidar da aka gano cewa glycidone na iya kasancewa a cikin nono.

Glycvidone yana cikin metabolized gaba daya a cikin hanta, akasari ta hanyar demethylation da hydroxylation. Glycvidone metabolites ba su da magungunan ƙwaƙwalwar ƙwayar cuta, ko nuna ayyukan da aka ɗanɗaɗa ɗan lokaci idan aka kwatanta da mahaifa na mahaifa.

Glycvidone metabolites an kebe shi musamman tare da feces, kuma karamin adadin su shine yake a cikin fitsari. Sakamakon bincike ya nuna cewa bayan sarrafa bakin, kusan kashi 86% na glycidone mai narkewar ciki an cire shi ta cikin hanji. Aƙalla 5% (a cikin nau'in metabolites) na kashi da aka ɗauka an keɓance ta ta hanjin kodan, kuma wannan aikin ba shi da ƙarancin magani kuma baya dogaro da hanyar gudanar da Glyurenorm. Ko da tare da amfani da miyagun ƙwayoyi na yau da kullun, an cire shi a cikin fitsari a cikin ƙananan abubuwan hankali.

Rayuwa rabin rai shine awa 1,2 (kewayon bambanci shine 0.4-3 hours), ƙarshen rabin rayuwar rabin shine kimanin awanni 8 (darajar na iya bambanta daga 5.7 zuwa 9.4 hours).

A cikin marasa lafiya na tsufa da tsaka-tsakin shekaru, sigogin magunguna suna kama da juna. A cikin marasa lafiya da keɓaɓɓen koda da hepatic tabarbarewa, mafi yawan glycvidone an excreted a feces. Akwai tabbacin cewa metabolism na aiki mai maganin yana rage kusan canzawa a cikin marasa lafiya tare da gazawar hanta. Tunda glycidone an kewaya ta cikin kodan a adadi kaɗan, babu tarin magani a cikin marasa lafiya da ke fama da tabin koda.

Umarnin don amfani da Glyurenorm: hanya da sashi

Ana amfani da glurenorm ta baki bisa ga shawarar likita game da kashi da abinci.

A farkon farawa, a matsayinka na doka, an tsara allunan a lokacin karin kumallo (a farkon cin abinci). Idan ba'a lura da cigaba ba, sannu a hankali ana kara yawan kashi.

Idan kashi na yau da kullun bai wuce allunan 2 ba, ya kamata a sha shi a cikin kashi 1 na safe. Idan ya wuce, ya zama dole a raba ta da allurai 2-3, amma a dauki bangare mafi girma da safe a karin kumallo.

Matsakaicin izini na yau da kullun shine 4 Allunan. Theara yawan ƙwayoyi fiye da allunan 4 ba shi da amfani, tun da ba ya haifar da ƙaruwa cikin inganci.

Kada tsallake cin abinci bayan shan Glyurenorm kuma dakatar da magani ba tare da tuntuɓar likita ba.

Lokacin da ake rubuta magani a cikin ƙwayar fiye da 75 MG (Allunan Allunan 2.5), marasa lafiya waɗanda ke fama da aikin hanta mai rauni suna buƙatar sa ido sosai game da yanayin.

Idan akwai ƙarancin tasirin asibiti yayin monotherapy tare da Glyrenorm, za'a iya tsara magani mai haɗuwa tare da metformin.

Side effects

Tsarin hematopoietic: leukopenia, thrombocytopenia, agranulocytosis,
Tsarin mara jijiya: nutsuwa, vertigo, paresthesia, ciwon kai, jin gajiya,
Tsarin zuciya: extrasystole, hauhawar jini, angina pectoris, rashin lafiyar zuciya,
Tsarin narkewa: tashin zuciya, rashin cin abinci, bushewar bushe, rashin jin daɗi a cikin ciki, maƙarƙashiya / zawo, amai, cholestasis,
Metabolism: hypoglycemia,
Organ na hangen nesa: mazaunin damuwa,
Fata da ƙananan ƙwayar cuta: tasirin hoto, tashin zuciya, ƙaiƙayi, ƙaiƙayi, cutar Stevens-Johnson,
Sauran: zafin kirji.

Yawan abin sama da ya kamata

Lyarfewar Glyurenorm na iya tayar da hauhawar jini, wanda aka ƙaddara ta waɗannan alamomin: damuwa tashin hankali, tachycardia, palpitations, magana mai rauni da hangen nesa, tsananin ɗaci, yunwar, tashin hankali, rashin bacci, ciwon kai, rawar jiki, sanyin gwiwa. Lokacin da alamun hypoglycemia ya bayyana, yana da buƙatar ɗaukar abinci mai arziki a cikin carbohydrates ko glucose (dextrose).Idan mai tsananin rashin haihuwa, tare da asarar hankali ko kwayar cutar kwayar cutar kwayar cutar ciki, ana sarrafa ma'adanin ciki a ciki. Bayan da mara lafiyar ya murmure, yakamata ya dauki carbohydrates cikin sauki domin gujewa sake kai harin.

Haihuwa da lactation

Ba a samun bayani game da amfani da glycidone a cikin marasa lafiya yayin daukar ciki da lactation. Matan da ke da juna biyu da aka kamu da cutar sankara suna buƙatar kulawa da kulawa akai-akai game da yawan ƙwayar cutar ta plasma. Shan magunguna na zub da jini a cikin marassa lafiya yayin daukar ciki baya bada garantin ikon sarrafa glycemic. A saboda wannan dalili, shan Glyurenorm a lokacin daukar ciki yana contraindicated.

Idan mai haƙuri ya sami juna biyu yayin jiyya tare da miyagun ƙwayoyi, ko kuma ta shirya shi, glycidone an soke shi kuma ya canza zuwa insulin.

Tare da aikin hanta mai rauni

Ba a ba da shawarar glurenorm ga marasa lafiya da mummunan cututtukan hanta ba, tun da kashi 95% na kashi da aka ɗauka ana metabolized a cikin hanta kuma an keɓe shi da feces. Nazarin asibiti wanda marasa lafiya masu ciwon sukari da dysfunctions na hanta daban-daban (ciki har da matsanancin hanta, tare da raunin hawan jini) ya dauki bangare, ya nuna cewa glycvidone bai kai ga ci gaba da lalacewar aikin hanta ba, karuwa a sakamakon tasirin sakamako, da kuma maganganun rashin karfin jiki. kasance ba ya nan.

Hulɗa da ƙwayoyi

Zai yiwu a haɓaka tasirin hypoglycemic na Glurenorm tare da gudanar da sabis na lokaci guda na magunguna masu zuwa: inginitors monoamine, magungunan anti-mai hana kumburi, furodusoshi, wakilai na antifungal, tricyclic antidepressants, tetracyclines, insulin, wasu maganganun maganganun maganganun-sake-sake-sake-mai-sake , sulfonamides, sulfinpyrazone, clofibrate, clarithromycin, chloramphenicol, allopurinol.

Sympatholytics (gami da clonidine), beta-blockers, guanethidine da reserpine ba wai kawai inganta tasirin hypoglycemic na Glyrenorm ba, amma a lokaci guda rufe alamun hypoglycemia.

Yana yiwuwa a rage tasirin hypoglycemic na Glyurenorm yayin da ake tsara magunguna masu zuwa: sympathomimetics, glucocorticosteroids, hormones thyroid, thiazide da loop diuretics, rigakafi na baka, shirye-shiryen acid, nicotinic acid, aminoglutetimide, phenothiazine, diazoxide, glupin, rifen.

Tare da amfani da lokaci ɗaya na ethanol, histamine H mai hanawa₂-receptors (alal misali, ranitidine, cimetidine), yana yiwuwa duka don haɓakawa da raunana tasirin hypoglycemic na Glyurenorm.

Misalin glurenorm shine: Amix, Glair, Glianov, Glibetic, Gliklada.

Abun ciki da nau'i na saki

Akwai wadatar glurenorm a cikin nau'ikan allunan, fararen farin tare da alamar "57C" da tambarin kamfanin a baya. Kowane kwamfutar hannu ya ƙunshi 30 MG na kayan aiki - glycidone, ana gabatar da abubuwan taimako a cikin nau'i na: lactose monohydrate, sitaci masara mai narkewa, bushe, magnesium stearate. Allunan an cika su cikin guda 10. a cikin blisters kunsasshen cikin kwali kwali na 3, 6 ko 12 inji mai kwakwalwa.

Sashi da gudanarwa

Ana ɗaukar allunan a baka. Shafin shan Glenrenorm da sashi na miyagun ƙwayoyi an ƙaddara su ne bisa tsarin metabolism na metabolism.

Yawanci, kashi na farko na maganin shine rabin kwamfutar hannu, ana bada shawara a sha shi a karin kumallo. Furtherarin gaba, idan ya cancanta, a hankali ana ƙara yawan kashi (bisa ga shawarar likita).

A cikin yanayin inda aka wajabta haƙuri 2 Allunan a rana, ana iya ɗaukar su a cikin tafi guda. Mafi girma allurai na Glenrenorm ya kamata a kasu kashi biyu ko uku.

Sharuɗɗan da yanayin ajiya

A cikin umarnin, yakamata a adana Glurenorm a wuri mai duhu, bushewa da rashin isar yara, a zazzabi a ɗakin.

Daga kantin magunguna, ana bayar da maganin ta hanyar takardar sayan magani. Rayuwar shiryayye na allunan, ƙarƙashin shawarar mai ƙira, shekaru biyar ne. Ba za a iya amfani da glurenorm ba bayan ranar karewa.

An sami kuskure a cikin rubutun? Zaɓi shi kuma latsa Ctrl + Shigar.

Aikin magunguna

Glurenorm yana haifar da tasirin cututtukan fata da ƙari, yana taimakawa haɓaka ƙwayar insulin ƙwaƙwalwar ƙwayar cuta (mafi mahimmanci mai amfani da metabolism metabolism) ta hanyar ƙwayoyin beta na pancreatic, yayin da kuma haɓaka aikin insulin, yana rinjayar ɗaukar glucose ta tsokoki da hanta, kuma yana hana lipolysis a cikin tsopose nama. Hankalin glucose a cikin jini yana fara raguwa sa'a daya bayan shan miyagun ƙwayoyi, ana samun mafi girman sakamako bayan sa'o'i 2-3, tsawon lokacin aikin Glenrenorm bisa ga sake dubawa shine 8-10 hours. Glurenorm yana narkewa daga narkewa, narkeoli a cikin hanta kuma an cire shi galibi ta hanjin hanji kuma kashi 5 cikin fitsari ne kawai.

Glurenorm, kasancewa mai samo asali na sulfonylurea, magani ne na ɗan gajeren lokaci, saboda haka ana ba da shawarar amfani da shi ga masu haƙuri waɗanda ke fama da ciwon sukari na 2 tare da haɗarin hauhawar jini (tsufa ko tare da aiki na keɓaɓɓen aiki). Hakanan, ana iya amfani da miyagun ƙwayoyi a cikin marasa lafiya da ke fama da cutar sankara ko kuma gazawar koda, tunda glycidone ya fitar da kodan a cikin mafi ƙarancin adadin.

Abunda ke ciki

Dangane da umarnin da aka haɗe zuwa Glurenorm, yin amfani da miyagun ƙwayoyi an hana shi cikin:

Lalacewar hanta,
Type 1 ciwon sukari
Cutar kamuwa da cutar siga da yanayin rashin lafiyar,
Jihohi bayan kamanceceniya,
Cutar cututtuka
Ciki da lokacin shayarwa,
Ayyukan tiyata tare da maganin tilas,
Galactosemia, rashi lactase,
A karkashin shekaru 18,
Rashin hankali ga miyagun ƙwayoyi.

Hakanan, tare da tsananin taka tsantsan, an wajabta maganin ga marasa lafiya da ke fama da cutar ta thyroid, tare da cututtukan febrile, kuma suna fama da buguwa.

Abun da ya shafi magani, kwatankwacinsa, shiryashi, tsari

Ta wacce hanya ake shirya Glurenorm? Umarnin yin amfani da shi ya sanar da cewa wannan samfurin ana samunsu ta fararen launuka masu santsi da launi na zagaye, tare da daraja da gefuna, da kuma zanan "57C" da tambarin kamfanin.

Babban bangaren maganin yana cikin tambaya shine glycidone. Hakanan ya hada da bushewar sitaci na masara, lactose monohydrate, sitaci masara mai narkewa da magnesium stearate (ƙarin mahadi).

Magungunan Glurenorm (Allunan) suna kan siyarwa a cikin blisters na guda 10, waɗanda aka cakuɗe a cikin fakitoci na kwali.

Aikin magunguna

Menene maganin Glurenorm? Koyarwar don yin amfani da rahotanni na yin amfani da cewa wannan wakili ne na ƙaƙƙarfar jini, mai samo asali na sulfonylurea (ƙarni na biyu). An yi nufin shi ne don gudanar da maganin baka.

Magungunan da ake tambaya yana da cututtukan cututtukan fata da cututtukan cututtukan fata. Yana karfafa rufin insulin kuma yana sanya hanyar glucose-tsakani ta hanyar samuwar sa.

Gwaje-gwaje a kan dabbobin dakin gwaje-gwaje sun nuna cewa maganin Glyurenorm, wanda koyarwarsa ke kunshe a cikin kwali mai kwali, na iya rage juriya ta insulin a cikin tsopose na nama da hanta. Wannan na faruwa ne ta hanyar motsawar aikin, wanda ke shiga tsakani ta hanyar insulin, da kuma karuwa a cikin masu karbarsa.

Tasirin hypoglycemic bayan shan miyagun ƙwayoyi ya haɓaka bayan minti 65-95. Amma ga mafi girman tasirin maganin, yana faruwa bayan kimanin sa'o'i 2-3 kuma yana ɗaukar kimanin sa'o'i 8-10.

Kinetic kadarorin

Umarnin don amfani da "Glyurenorm" ya faɗi cewa amfani da kashi ɗaya na wannan magani (15-30 mg) yana ba da gudummawa ga saurinsa da cikakkiyar ƙwayar jijiyoyin ƙwayar cuta (kimanin kashi 80-95%). Ya kai kololuwar hankalinsa bayan awa 2.

Abubuwan da ke aiki na miyagun ƙwayoyi suna da alaƙa da ƙarfi ga furotin plasma.

Babu bayanai game da yiwuwar glycidon ko abubuwan da yake samowa ta cikin mahaifa ko BBB. Har ila yau, babu wani bayani game da shigarwar glycidone zuwa cikin nono.

Ina metabolism na miyagun ƙwayoyi "Glyurenorm"? Umarnin don yin amfani da jihohi ya nuna cewa maganin da ake magana da shi yana aiki ne a cikin hanta ta hanyar lalata da ruwa.

Mafi yawan abubuwanda ake amfani da su a cikin glycidone an cire su ta cikin hanjin. Rabin rayuwar wannan magani shine 1-2 awanni.

A cikin tsofaffi da marasa lafiya na tsaka-tsaki, matakan jinni na Glyurenorm suna kama.

A cewar masana, metabolism na wannan magani ba ya canzawa a cikin marasa lafiya da gazawar hanta. Ya kamata kuma a san cewa a cikin marasa lafiya da ke fama da rauni na aikin koda, ƙwayar ba ta tarawa.

A karkashin wane yanayi ne magani "Glurenorm" yafi tasiri? Umarnin don amfani, sake dubawa sun ba da alama cewa alama don amfani da ita ita ce nau'in mellitus na sukari na 2 a cikin tsofaffi da mutanen da ke tsakiyar (tare da rashin ingancin maganin abinci).

Haramtattun hanyoyin shan magani

A cikin wane yanayi ne ake yin allurar rigakafin allurar Glurenorm? Umarnin don amfani yana nuna mai zuwa ga aikin wannan magani:

mnfitsari m,
Type 1 ciwon sukari
mai tsanani hanta,
acidosis masu fama da ciwon sukari, precoma, ketoacidosis da coma,
lokacin bayan kamawar farji,
cututtuka masu saurin kisa kamar galactosemia, rashin haƙuri da lactose, rashin maganin lactase da glucose-galactose malabsorption,
matsanancin yanayin haƙuri (alal misali, tiyata mai tsanani, cututtukan cututtuka),
lokacin haihuwa
karamin shekaru (saboda karancin bayanai kan amincin da kuma magunguna a cikin wannan rukunin shekarun),
lokacin shayarwa
rashin kwanciyar hankali ga sulfonamides.

Magungunan "Glurenorm": umarnin don amfani

Allunan kwalajin glurenorm an wajabta kawai a ciki. Lokacin shan su, dole ne ku bi duk shawarar likita game da sashi na maganin da rage cin abinci. Haramun ne a daina shan maganin ba tare da fara tuntuɓar kwararrun likita ba.

Kashi na farko na maganin a cikin tambaya shine Allunan 0.5 (i.e. 15 mg) yayin karin kumallo na farko. Ya kamata a sha maganin a farkon cin abincin. Bayan cin abinci, tsallake abinci haramun ne.

Idan amfani da kwamfutar hannu na 1/2 ba ya haifar da haɓaka, to, bayan tuntuɓar likita, yawanci ana ƙara yawan sashi. Tare da kashi ɗaya na yau da kullum na "Glyurenorm" ba fiye da allunan 2 ba, ana iya ɗaukar sau ɗaya yayin karin kumallo.

Idan likita ya ba da ƙarin adadin magunguna, to don mafi kyawun sakamako ya kamata a raba su zuwa 2 ko 3 allurai.

Theara yawan ƙwayoyi fiye da allunan 4 a kowace rana yawanci ba sa ƙaruwa sosai. Saboda haka, shan magani "Glyurenorm" a cikin adadin da aka ƙayyade ba da shawarar ba.

A cikin mutanen da ke fama da rauni na aiki, ba a buƙatar daidaita sashi ba.

Shan magungunan sama da 75 MG a cikin marasa lafiya da ke fama da cutar hanta na buƙatar kulawa ta yau da kullun daga likita.

Game da isasshen sakamako na warkewa, tare da "Glurenorm" za'a iya ɗaukar haƙuri mai ƙari kuma "Metformin".

Adadin kararraki

Shan manyan allurai na sulfonylurea abubuwanda ake haifar dasu koda yaushe yakan haifar da rashin karfin jini. Bugu da kari, yawan shan wannan magungunan na iya haifar da alamomin kamar haka: sweating, tachycardia, irritability, yunwa, ciwon kai, palpitations, rawar jiki, rashin bacci, tashin hankali na motsa jiki, hangen nesa da magana.

Lokacin da alamun hypoglycemia ya bayyana, dole ne ku dauki glucose ko abinci mai wadatar carbohydrates.

Side effects

Yanzu kun san dalilin da yasa aka sanya magani irin su Glurenorm. Umarnin umarnin yin amfani da wannan magani shima an duba shi a sama.

Dangane da marasa lafiya, yayin shan wannan magani, zaku iya dandana:

thrombocytopenia, angina pectoris, agranulocytosis,
paresthesia, hypoglycemia, dizziness,
leukopenia, ciwon kai, extrasystole, nutsuwa,
masauki damuwa, gajiya, hypotension,
kasawar zuciya, bakin bushewa, cututtukan Stevens-Johnson,
rage cin abinci, yanayin daukar hoto, tashin zuciya, rash,
urticaria, vomiting, kirji zafi, cholestasis,
maƙarƙashiya, itching na fata, zawo, rashin jin daɗi a cikin ciki.

Abun Harkokin Magunguna

Tare da gudanarwa na lokaci guda na glycidone tare da Allopurinol, ACE inhibitors, antifungal kwayoyi, analgesics, Kalaman coumarin, NSAIDs da sauran su, ana iya inganta tasirin hypoglycemic na tsohuwar.

Rifampicin, barbiturates, kazalika da Phenytoin rage tasirin hypoglycemic na Glyurenorm.

Shawara ta musamman

Ma'aikatan hypoglycemic don maganin baka bai kamata su maye gurbin abincin warkewa ba.

Mutanen da ke da ciwon sukari ya kamata su bi duk shawarar likita.

Lokacin da alamun hypoglycemia ya bayyana, yakamata a ɗauki abincin da ke kunshe da sukari.

Ayyukan jiki na iya inganta tasirin hypoglycemic na miyagun ƙwayoyi.

Saboda gaskiyar cewa glycidone da kodan ba shi da mahimmanci, ana iya tsara magungunan da ke cikin amintaccen lafiya ga marasa lafiya tare da nakasa na koda, da kuma cututtukan ciwon suga.

A yayin nazarin karatun asibiti, an gano cewa yin amfani da miyagun ƙwayoyi a cikin tambaya na watanni 30 bai ba da gudummawa ga karuwar nauyin haƙuri ba. Haka kuma, akwai lokuta masu nauyin asara ta hanyar kilogiram 1-2.

Analogs da sake dubawa

Ana amfani da magungunan masu zuwa ga Glurenorm analogues: Gliklada, Amiks, Glianov, Glayri, Glibetik.

Reviews game da miyagun ƙwayoyi a tambaya ana iya samun daban. Dangane da rahoton mabukaci, wannan magani yana da tasiri sosai kuma yana isa ga kowa. Koyaya, ya kamata a lura cewa yawancin marasa lafiya suna da matukar damuwa game da jerin halayen marasa illa na wannan maganin. Kodayake likitoci suna da'awar cewa suna da matuƙar wuya kuma kawai a ƙarƙashin wasu yanayi.