Acarbose don ciwon sukari
1S- (1alpha, 4alpha, 5beta, 6alpha) -0-4,6-dideoxy-4-4,5,6-trihydroxy-3- (hydroxymethyl) -2-cyclohexen-1-ylamino-alpha-D-glucopyranosyl- (1-4) -0-alpha-D-glucopyranosyl- (1-4) -D-glucose ko (2R, 3R, 4R, 5S, 6R) -5- (2R, 3R, 4R, 5S, 6R) - 5- (2R, 3R, 4S, 5S, 6R) -3,4-dihydroxy-6-methyl- 5- (1S, 4R, 5S, 6S) - 4,5,6-trihydroxy-3- (hydroxymethyl) cyclohex-2-en-1-ylaminooxan-2-yloxy-3,4-dihydroxy-6- (hydroxymethyl) oxan-2-yloxy-6- (hydroxymethyl) oxan-2,3,4-triol (IUPAC).
Abubuwan sunadarai
Carbohydrate daga kungiyar oligosaccharides Acarbose foda ne, fari ko fari tare da kowane inuwa, wanda yake narkewa cikin ruwa. An samo abu daga Hakanan amfani da fermentation. Tsarin kwayoyin sunadarai shine giram 645.6 a kowace kwayar. An fito da miyagun ƙwayoyi a cikin nau'in Allunan, a sashi na 50 ko 100 MG.
Magunguna da magunguna
Kayan aiki ya fallasa oligo da polysaccharides hydrolysis halayen by m hanawa daga cututtukan hanji alfa amylases da hanji membrane-daure alpha glucosidases. A ƙarƙashin tasirin acarbose, ƙwayar ƙananan hanji yana karye di, oligo da samartar zuwa daban-daban monosaccharides da glucose. Intensarfafa samuwar da kuma shan gulukos a cikin hanji yana raguwa, matakin glucose na yau da kullun a cikin jini ya inganta. Magungunan ba ya zuga ci gaban insulin kuma baya kaiwa zuwa yawan haila.
Abincin ba mutagenic bane, baya shafar haihuwa da ikon haifuwa gabaɗaya.
Tare da tsarin kulawa da miyagun ƙwayoyi a cikin marasa lafiya da raunin glucose mai wahala, haɗarin nau'in ciwon sukari na 2, infarction na zuciya da cututtukan zuciya.
Acarbose yana da karancin darajar sha, na kusan kashi 35%. A bioavailability na tsari na 1-2%. Matsakaicin mafi yawan abubuwan da kanta ana lura da ita a cikin jini sa'a daya bayan gudanarwa, da kuma metabolites - bayan sa'o'i 14 - a rana.
A cikin mutanen da ke fama da gazawar koda, matsakaicin matakin taro yana ƙaruwa har sau 5, a cikin tsofaffi marasa lafiya wannan alamar tana ƙaruwa sau 1.5.
Magungunan yana metabolized a cikin narkewa tare da shiga cikin ƙwayoyin hanji da kuma narkewar enzymes, kusan metabolites 13 suna Acarbose. Waɗannan su ne ainihin abubuwan asali 4-methylpyrogallol. Abun da ba'a canza ba (kusan rabin kashi) an fesa shi a cikin feces cikin awa 96. Kusan 35% na miyagun ƙwayoyi an keɓe su a cikin hanyar metabolites ta hanyar kodan. Kashe rabin rayuwar shine 4 hours (lokaci rarraba) kuma har zuwa 10 hours (lokaci na musamman).
Contraindications
Magungunan yana contraindicated a shan:
- a rashin lafiyan mutum zuwa Acarbose
- marasa lafiya tare da mai fama da ciwon sukari ketoacidosis, cirrhosis,
- a cikin na kullum da m kumburi cututtuka, tare da narkewa da kuma cuta cuta,
- mara lafiya tare da Tunani na Ciwan,
- lactating mata
- tare da cututtuka na narkewa kamar jijiyoyi, tare da shi maganin ulcerative colitis, rashin tsorotoshewar hanji (gami da bangare),
- marasa lafiya da tsauraran hanji da cututtukan hanji, manyan hernias,
- a na kullum na gazawar,
- a lokacin ciki.
Ana nuna taka tsantsan yayin ɗaukar Acarbose:
- marasa lafiya da cututtuka, raunin da ya faru, bayan tiyata,
- iya zazzabi,
- mutane yan kasa da shekara 18.
Side effects
Mafi yawan raunin da aka saba samu daga ƙwayar gastrointestinal:
- karuwar gas, zawojin zafi a ciki, amai, ƙarancin ciki,
- tashin zuciya, cikakken ko kuma m bowel,
- jaundice, haɓaka ayyukan hanta enzymes, hepatitis.
Hakanan an lura: kumburi, thrombocytopenia, cututtukan mahaifafata rashes, erythema.
Acarbose, umarnin don amfani (Hanyar da sashi)
Allunan ana yin allunan a baki, mintuna 20 kafin abinci ko awa daya bayan cin abinci.
A matakan farko na magani, ana amfani da 50 MG na miyagun ƙwayoyi sau 3 a rana, to, a hankali ana ƙaruwa sashi zuwa 0.1-0.2 grams, gwargwadon haƙuri.
A matsakaici, sashi na marasa lafiya wadanda ke kasa da kilogiram 60 shine 50 MG, fiye da kilogiram 60 shine 300 MG kowace rana. Matsakaicin adadin yau da kullun shine 0.6 grams.
Don rigakafin, ana sanya magani a 50 MG kowace rana, kuma sannu a hankali yana ƙaruwa zuwa 0.1 grams sama da watanni 3.
Haɗa kai
An inganta tasirin hypoglycemic na miyagun ƙwayoyi ta hanyar abubuwan da suka samo asali sulfonylureas, metformin, insulin.
Colestyramine, antacids da adsorbents waɗanda ke aiki a cikin hanji, rage tasirin magani tare da Acarbose.
Glucocorticosteroids, estrogensglandon hailar, thiazide diuretics, phenothiazines, phenytoinmaganin hana haihuwa nicotinic acid, isoniazid, adrenostimulants da sauran ƙwayoyi suna haifar yawan haila rage mahimmancin ayyukan miyagun ƙwayoyi, har zuwa lalata ciwon sukari mellitus.
Umarni na musamman
A lokacin jiyya tare da miyagun ƙwayoyi, wajibi ne a bi shawarar likita, bi abinci. Abinci da abinci mai ɗauke da ƙwayoyin carbohydrates da sukari na iya haifar da tashin hankali na hanji.
A yayin jiyya, an kuma bada shawara don sarrafa sukari na jini da matakan fitsari glycosylated haemoglobin da kuma transaminases, musamman a farkon watanni 12 na magani.
Tare da karuwar kashi fiye da gram 0.3 a rana, raguwa mai laushi zai faru hawan jini da kuma kara hadarin bashin.
Yayin kulawa tare da samfurin, ya kamata a tuna da cewa sukari abinci na yau da kullun yana karyewa a hankali kuma baya samun ikon kawar da sauri yawan haila. Don kawar da wannan yanayin, ana bada shawara don amfani da allurai masu yawa glucose (ba sucrose), zai fi dacewa a cikin intravenally.
Magungunan, a matsayin mai mulkin, ba a wajabta shi ga yara 'yan ƙasa da shekara 18 ba.
Shirye-shirye waɗanda suka ƙunshi (Analogs)
Reviews a kan miyagun ƙwayoyi don magance ciwon sukari mafi yawa tabbatacce. Sakamakon mafi yawan abin da ke haifar da damuwa yana haifar da karuwar gas da rashin damuwa na ciki. Nazarin game da Acarbose don asarar nauyi sun rarrabu. Wannan magani ya dace da wani, kuma wani bayan shan kwayoyin yana fara cinye Sweets kuma ya rasa iko. Ya kamata a lura cewa yayin magani yana wajaba a bi tsarin abinci, in ba haka ba, rage tasirin magani yana ragu sosai.
Farashin Acarboza, inda zaka siya
Farashin allunan Glucobai kusan 560 rubles ne don guda 30, tare da sashi na 100 MG.
Ilimi: Ta yi karatun digiri a Kwalejin Kimiyya ta Kasa ta Rivne tare da digiri a fannin Kasuwanci. Ta yi karatun digiri a Jami'ar Likita ta Vinnitsa. M.I. Pirogov da kuma aikin horon dan adam dangane da shi.
Kwarewa: Daga 2003 zuwa 2013, ta yi aiki a matsayin mai kantin magani kuma manajan kantin sayar da kayayyaki na kantin magani. An ba ta haruffa da rarrabe har tsawon shekaru na aikin da ta yi. An buga labaran kan batutuwan likitanci a cikin mujallu na gida (jaridu) da kuma wasu hanyoyin yanar gizo da dama.
Yawon shakatawa na tarihi
Yunkurin ceton bil adama daga “annobar zaƙi” an yi shi a karni na ƙarshe.
Gaskiya ne, kamar yadda ƙididdiga suka nuna, to babu yawan masu ciwon sukari da yawa. Cutar ta fara yadu sosai lokacin da kantunan shagunanmu suka fara karyewa daga samfuran inganci, saboda Soviet GOSTs sun soke, kuma sabbin yanayin fasaha bai iya takaita masana'antar ba a gwaje-gwajen lafiya.
Sanin cewa babbar matsala ta ciwon sukari mellitus (DM) take hakkin metabolism, masana kimiyya sunyi ƙoƙarin haɓaka magani na duniya wanda ke iyakance amfani da carbohydrates, wanda ke samar da wani mutum tare da rabin rabin adadin adadin kuzari.
Tabbas, a yau babu wanda ya yi nasarar cin nasarar wannan burin ba tare da rage cin abinci mai ƙoshin abinci ba, amma ƙarin haɓakar mai da metabolism na metabolism ba zai cutar da masu ciwon sukari ba, musamman tunda kaɗan daga cikinsu suna da ikon bi don shawarwarin masana ilimin endocrinologist.
Bayan yin lissafin abincin yau da kullun na masu ciwon sukari:
- Monosaccharides (a cikin nau'in fructose da glucose) - 25 g,
- Disaccharides (sucrose) - 100g,
- Polysaccharides (kamar sitaci) - 150g.
Za'a iya fahimtar cewa toshe matatun mai yafi dacewa a matakin farko na metabolism, a cikin hanji, daga inda zasu fito da asalin su.
Me yasa aka mai da hankali sosai ga sitaci? Amfani da sinadarin α-amylase ya ƙunshi amylose da amylopectin, kuma ana iya rugujewa zuwa disaccharides ta amfani da tonon da hanji, wanda ke ɗauke da enzymes α-amylase. Abubuwan disaccharides sun rushe zuwa glucose da fructose a cikin hanji a ƙarƙashin tasirin α-glucosidases. Wadannan monosaccharides ne suka shiga cikin jini daga hanji.
Babu shakka raguwa a cikin ayyukan ƙwayar kumburin da hanji zai rage jinkirin lalacewar adadin carbohydrates da ke shiga jiki tare da abinci. Masu hana enzymes saccharolytic, waɗanda aka samo a wasu tsire-tsire (alal misali, a cikin stevia), suna da sauƙin digestible kuma kada ku bayar da sakamakon da ba a so. An samo analogs a cikin buckwheat, hatsin rai, masara, legumes da gyada. Abin takaici, karfin su bai isa ba don sarrafa glycemic na ƙididdigar jini.
An gano ƙananan ƙwayoyin cuta suna da tasiri sosai, wanda daga cikinsu aka sami masu hanawa tare da nau'ikan sakamako masu illa: sunadarai, aminosaccharides, oligosaccharides, glycopolypeptides. Mafi shahararren maganin olisaccharide shine Acarbosum, wanda aka kirkira shi daga ƙananan ƙwayoyin cuta. Ta hana ƙananan hancin glucoseidases na hanji, yana rage jinkirin canza sitaci cikin glucose.
Sauran hanyoyin da aka kirkira daga ciki an inganta su ne ta hanyar tsarin ascarbose, amma basu da wannan tasirin.
Hanyar magunguna
Magungunan Ascarbose:
- Rage gudu daga abubuwan karfafawa a cikin hanjin,
- Rage postprandial (bayan cin abinci, “prandial” - “abincin rana”) glycemia,
- Ta hana hauhawar jini,
- Kare yiwuwar karuwar insulin.
Lokacin cin abinci tare da babban taro na carbohydrates, sakamakon hypoglycemic na ascarbose an lura da shi musamman.
Mai hana daukar ciki na taimakawa wajen yakar kiba, da rage yawan ci da kuma yawan adadin kuzari na abinci na yau da kullun, da kuma rage yawan kitsen visceral.
Addu'o'i masu kitse, kayan abinci mai-mai-girma suna rage tasirin acarbose, tunda tasirin sa shine ya zama al'ada game da sinadarin carbohydrate, maimakon maganin kiba.
Acarbose ta hanyar aikin yayi kwatankwacin karfin zare, dayan fizirin wanda yake zama dunƙule, ba don narkewar abinci daga enzymes ba. Bambanci shine cewa miyagun ƙwayoyi suna hana ƙarfin enzymes kansu. Kamar yadda yake cikin rashin kulawar kwayar halitta, carbohydrates suna zama “ba za'a iya canzawa ba” saboda ruwan 'ya'yan itace na ciki da kuma fita ba canzawa, yana kara adadin jijiyar wuya. Daga wannan yana biye da damar inhibitor na iya haɓaka idan ana amfani da samfuran da keɓaɓɓun fiber a cikin layi daya. Wannan dabarar tana da tasiri sosai wajen rasa nauyi.
Duk da katange kayansa, mai hanawa baya keta alfarmar aikin ciki, tunda baya tasiri amylo-, proteo- da lipolytic na abubuwan narkewar abinci.
Abubuwan da ke tattare da miyagun ƙwayoyi kuma sun dogara da kashi: tare da karuwa a cikin al'ada, alamun hypoglycemic sun fi hakan girma.
Masu ciwon sukari da ke shan acarbose da abubuwan da ta samo sun nuna sakamako mai kyau a cikin wasu sigogi masu mahimmanci:
- Rage triglycerol da cholesterol a cikin jini,
- Rage cikin lipoprotein lipase maida hankali a cikin nama nama.
Idan mai hana injection ya shiga cikin ciki kai tsaye, hakan yana hana ayyukan α-glucosidases. Carbohydrates suna narkewa sosai har sai da wani sashi daga cikinsu ya ke canzawa. Wannan yana shafar alamomin glucometer ta hanyar da ta fi dacewa: kodayake sun haɓaka, ba su da mahimmanci kamar ba tare da haɗarin acarbose ba. Dangane da tasiri, ana iya kwatanta shi da mashahurin Metformin, wanda ke cikin masu ciwon sukari tare da gazawar koda.
Acarbose kuma an wajabta shi don nau'in ciwon sukari na farko, tunda yin amfani da shi yana rage adadin ƙarin insulin zuwa rabi.
Magungunan za su taimaka wajen daidaita al'ada, amma abincin yana buƙatar daidaita shi, tunda rashi na carbohydrate yana da haɗari kamar wuce haddi.
Ko da a cikin maganganun ci gaba, tare da ciwon sukari mai lalacewa, lokacin da insulin ya biya sukari, bayan hanya guda na maganin acarbose, masu ciwon sukari sun lura da raguwa a cikin glucosuria (kasancewar glucose a cikin fitsari).
Yana haɓaka magunguna da haƙurin glucose, amma ba sauyawa 100% bane don magunguna na yau da kullun don maganin ciwon sukari. An wajabta shi azaman ƙarin magani a hade tare da jiyya. Misali, acarbose zai inganta tasirin sulfonylurea.
Hakanan ana nuna magungunan ga masu matsalar rashin lafiyan da basa iya jure wa insulin.
Yana da mahimmanci cewa wannan nau'in inhibitor bashi da cututtukan carcinogenic, embryotoxic da mutagenic.
An magance maganin a cikin narkewa a ciki, kwayoyin cuta da enzymes suna taimakawa wajen kirkirar abubuwa iri 13. Acarbose wanda ba a amfani dashi an saki shi ta cikin hanjin cikin awa 96.
Ga wanda aka nuna acarbose da contraindicated
An wajabta mai hanawa:
- Type 2 ciwon sukari
- Carbohydrate metabolism
- Rashin lafiyar metabolism,
- Cutar sukari
- Kiba
- Rashin haƙuri,
- Take hakkin azumi glycemia,
- Lactate da ciwon sukari acidosis,
- Type 1 ciwon sukari.
Yin amfani da acarbose an hana shi cikin:
- Ciwon hanta,
- Maryamma,
Kumburi da raunuka na gastrointestinal fili,- Cutar mahaifa
- Abin tozartawa na ciki,
- Cutar mai fama da ciwon sukari,
- Ciki, lactation,
- Shekarun yara.
Kumburi da raunuka na gastrointestinal fili,Tare da taka tsantsan, an wajabta maganin acarbose da abubuwan da ke tattare da shi bayan raunin da ya faru, a lokacin cututtukan cututtuka, tun da jikin da ya raunana bashi da isasshen ƙarfin da zai murmure. Tare da rashi na glucose ko toshewarsa, zazzagewar hypoglycemia ko ciwo na acetonemic mai yiwuwa ne.
Daga cikin sakamako masu illa suna yiwuwa:
- Hanyoyin motsa jiki
- Rashin lafiyar mazaunin ciki
- Increaseara yawan taro na transaminases,
- Hematocrit ragi
- Rage abun ciki na bitamin da alli a cikin jini,
- Kumburi, itching, rashin lafiyan halayen.
Rashin damuwa na ciki, ciwon ciki da sauran matsaloli tare da ciki da hanjin ka na iya faruwa sakamakon gaskiyar jinkirin narkewar ƙwayar carbohydrates yana ba da gudummawar cewa wasu daga cikinsu suna tarawa a cikin narkewar abinci kuma suna can tsawon lokaci kafin su shiga babban hanjin. Abubuwan da ake tarawa masu daɗi suna haifar da haɓakar ƙwayoyin ƙwayoyin cuta wanda ke haifar da fermentation, flatulence, da sauran cututtukan cututtukan cututtukan ɗoki.
Ana lura da irin wannan sakamako a cikin samar da shampen, lokacin da ƙwayoyin carbohydrate-dogara da ƙwayoyin ƙwayar ƙwayar cuta suna yin innabi na sukari, suna barin sakamakon rayuwarsu ta wucin gadi. Wataƙila, da tunanin tunanin wannan hoton, da yawa zasu daina barasa.
Kuna iya magance hadari a cikin hanji tare da metronidazole, wanda likita ya tsara a layi daya tare da acarbose. Carbon da aka kunna da sauran sihirin da ke kwantar da hancin microflora na hanji suna da irin wannan sakamako.
Yana rage tasirin maganin acarbose na lokaci-lokaci:
- Estrogen
- Magungunan Hormone don glandar thyroid,
- Na'urar hana haihuwa
- Masu maganin kishi
- Phenothiazines da sauran magunguna.
Acarbose - umarnin don amfani
A cikin umarnin, an kayyade sashi daidai da nauyin mai haƙuri. Idan, alal misali, mai ciwon sukari yana da nauyin jikinsa na nauyin kilogram 60, kashi 25-25 mg ya ishe shi, tare da mafi girman tsarin, an tsara 100 MG 3 / Ranar.Dole ne a kara yawan mai hana inhibitor a matakai, domin jiki ya iya daidaitawa, kuma ana iya gano halayen masu illa a lokaci.
Shan magani kafin abinci ko a lokaci guda. Ana wanke shi da kowane ruwa, idan abun ciye-ciye ne da ba a da fitsari, ba za a iya ɗaukar acarbose ba.
Idan jiki ya amsa rashin ƙarfi ga ƙwayar da aka zaɓa, ana iya haɓaka shi zuwa 600 MG / rana. kuma harma idan lafiya ta bada dama.
Inhibitor Analogs
Mafi shahararren analog na acarbose shine Glucobay. Hypoglycemic wakili an samar da shi a Jamus. Fitar saki - allunan da ke nauyin 50-100 MG, kowane kunshin ya ƙunshi guda 30 zuwa 100.
Baya ga asalin magani a China da Turai, zaku iya siyan janareta tare da sunan Glucobay, a Amurka da Ingila - Precose, a Kanada - Prandase. Ga masu fama da cutar sankara tare da abinci na gabas, magani yana da tasiri sosai, kuma ya shahara sosai a China, a cikin Amurka - akasin haka, amfani da shi yana da iyaka saboda zawo da ƙwarji.
Nasihu game da acarbose
Game da miyagun ƙwayoyi tare da acarbose Glucobay, sake dubawa game da rasa nauyi sune rarrabuwa. Ba a yi nufin maganin ba don asarar nauyi, an wajabta shi ga masu ciwon sukari, sau da yawa na nau'in na 2.
Tun da yawa daga cikin mu sun sami makamashi daga carbohydrates, magani na doka yana taimaka wa masu ciwon sukari da waɗanda suka rasa nauyi ci gaba da rage cin abinci kuma basu da mummunar illa kamar analogues, saboda ana iya ɗauka da ma'ana kafin wani yanki na cake ko wani jaraba na carbohydrate.
Aikin magunguna
Yana da tasirin hypoglycemic. Mai hanawa wanda ke hana aikin enzymes wanda ke rushe carbohydrates zuwa cikin sukari mai sauki. Shaye abubuwa na carbohydrates a cikin hanji yana raguwa, matakin glucose ya zama mai karko. Acarbose ya dace musamman ga waɗanda ke da rashin lafiyar insulin ko ba su dace da maganin metformin ba saboda cututtukan ƙwayoyin cuta. Ba shi da kaddarorin dabbobi, yana da aminci ga jiki fiye da sauran magunguna. Yana shafar katsewar cututtukan jini bayan cin abinci kuma yana rage yiwuwar ci gabanta. Yana rage yawan ci, yana taimakawa ci gaba da nauyin al'ada, yana hana ci gaban insulin haɓaka. Musamman bayyanar tasirin acarbose lokacin da aka ɗauke shi da samfuran carb. Bugu da ƙari, haɗuwar cholesterol da triglycerides a cikin jini yana raguwa, kuma lipoprotein lipase a cikin ƙwayoyin adipose.
Yaya acarbose yake aiki? Kamar fiber, yana sanya carbohydrates a cikin ruwan 'ya'yan itace na ciki da kuma aikin enzymes wanda ya rushe su zuwa monosaccharides. Sakamakon haka, an fesa su a cikin feces, amma aikin ciki ba shi da damuwa.
Pharmacokinetics
Yana aiki a cikin ƙwayar gastrointestinal, yana tunawa da nau'i na metabolites. Ana lura da mafi girman maida hankali bayan awa daya. Yana cikin metabolized a cikin narkewa kamar kansa, an keɓe shi a feces na awanni 96, haka kuma da kodan ta hanyar metabolites (34%).
- Ciwon sukari mellitus iri biyu a hade far,
- Cutar sukari
- Kiba mai yawa a matsayin cututtukan ciwon sukari,
- Insulin juriya ko rashin lafiyan.
Umarnin don amfani (hanya da sashi)
Oneauki kwamfutar hannu guda a baka sau uku a rana kafin abinci. Amfani da azaman talla a hade warkewa. Sashin likita yana ƙaddara sashi gwargwadon bincike. Maganin farko shine 25 MG. A hankali zaku iya haɓaka, amma a lokaci guda ku lura da haɓaka sakamako masu illa. Matsakaicin da aka tsara shine 600 MG kowace rana. Tsawan lokacin magani akalla watanni 6 ne. Yana da matukar muhimmanci a bi abinci.
Yawan abin sama da ya kamata
Akwai raɗaɗin ciki, gudawa da rashin jin daɗi. Ana cire cututtukan cututtukan ta hanyar cire abinci mai dauke da carbohydrate daga abincin.
Tare da haɗin gwiwa, hypoglycemia na iya haɓaka. Alamar ta: rauni, pallor, rashin iyawa (har zuwa kwaro), yunwar, damuwa, da sauransu. Za'a iya cire hypoglycemia da kansa ta hanyar cin abinci tare da carbohydrates. Ana cire matsakaici da mai tsanani ta hanyar allura da glucagon ko bayani mai faɗi. A wannan yanayin, ana buƙatar daidaita sashi.
Hulɗa da ƙwayoyi
Yana rage tasirin adsorbents na ciki da enzymes.
Yana haɓaka aikin insulin, metformin, sulfonylurea, wanda ke barazanar haɓakar haɓakar cutar hanta.
Abubuwa masu zuwa suna raunana sakamakon acarbose:
- karin bayani
- hodar iblis,
- corticosteroids
- phenytoin
- sabbinna,
- tausayawa
- estrogens, maganin hana haihuwa,
- masu maganin tashin zuciya
- nicotinic acid
- isoniazid da sauran jami'ai waɗanda ke haifar da hauhawar jini.
Babu takamaiman ma'amala da halayen da aka lura. Abu ne mai sauki a jure.
Kwatanta tare da analogues
Acarbose wani bangare ne na magunguna da yawa. Yi la'akari da kaddarorinsu da sifofinsu dalla dalla.
Bayer ne ke samar da shi a cikin kashi biyu - 50 da 100 a 100. Wannan shine mafi yawan lokuta ana rubuta shi ta likitoci. Farashi - 360-500 rubles, gwargwadon yawan abu. Glucobay an kafa shi sosai a kasuwar magunguna, kayan aiki ne mai inganci don rasa nauyi a cikin ciwon sukari a hade tare da ilimin abinci.
Kamfanin masana'antar Turkiyya ne ya samar da su. Sashi na 50 ko 100 MG. Effectivewararren magani ga masu ciwon sukari, yana da kyakkyawan bita. Kadan - yana da wuya a samu a cikin magunguna na Rasha.
Ya ƙunshi liraglutide, wanda ke shafar ayyukan ƙwayoyin beta a cikin ƙwayar ƙwayar cuta. Yana haifar da raguwa a cikin sukari na jini, dan kadan yana rage jinkirin narkewar ciki, wanda ke taimakawa rage nauyi. Aikace-aikace suna kama da acarbose. Akwai shi ta hanyar samar da mafita don gudanar da aikin ƙasa. Mai samarwa - "Novo Nordisk", Denmark. Farashi - daga 9000 rubles don almakana na syringe biyu. Sanya lokacin da allunan basu da amfani. Za'a iya amfani da Victose don maganin haɗari tare da insulin da sauran magungunan hypoglycemic.
Allformin Allunan don hadadden magani. Daga 500 rubles a kowane fakiti. Sashi ya bambanta, ana wajabta magani bisa ga bukatun mutum. Kamfanin kamfanin Berlin-Chemie ne, Jamus. Yana shafar aikin sel sel a cikin koda, wanda ke taimakawa rage yawan glucose da kiyaye nauyin al'ada. Kayayyakin suna kama, suna maye gurbin juna. Iyakar abin da Siofor kawai ke yi shine cewa metformin bai dace da kowa ba. Contraindications iri ɗaya ne.
Yin amfani da kowane analog yana gudana tare da izinin likita mai halartar. An haramta shan magani!
Gaba ɗaya, nazarin masu ciwon sukari game da magungunan tushen acarbose suna da inganci. Wasu marasa lafiya suna lura da ci gaban sakamako masu illa a cikin yanayin rashin daidaituwa da sauran matsalolin narkewa. Kusan kowa yayi magana game da daidaitaccen nauyi da rage yawan sukarin jini.
Natalya: "Ina ɗaukar Glucobay tsawon wata ɗaya yanzu. An fara da 50 MG akan shawarar likita, yanzu an kawo shi zuwa 100 MG. Hadawa tare da Novonorm. Gobe da rana sugar fitar da sharuddan. Ko da na karya abincin, sai ya ƙi. Amma sannan akwai sakamako masu illa a cikin hanyar rushewar hanji. Saboda haka, Ina ƙoƙari in bi umarnin likita kuma in bi abincin. ”
Vladislav: “Likita ya ba da“ Glucobai ”, wanda ke ɗauke da acarbose, bayan na kasance mai rashin lafiyar metformin. Don farashin, wannan magani ya dace da ni, Ina amfani da shi azaman ƙarin magani. Ikon glucose ya zama mafi kyau, muna murna da cewa babu haɓakar jini. A farkon farkon magani akwai rashin tsoro, likita ya ba da ƙarin ƙarin magunguna, komai ya koma daidai. Na yi farin ciki da sakamakon, kuma nauyin ya inganta, wanda na dade ina kokarin cimmawa. ”
Oleg: “Ina da cutar sukari guda 2. An sami matsaloli game da zaɓi na ƙarin magani don babban hanyar. Na riga na gwada Allunan da yawa tare da metformin, amma ba su dace da ni ba bisa ga alamun (matsalolin koda). Likitan ya ba da shawarar yin amfani da magani ta hanyar acarbose, wato “Glucobay”. Na kwashe shi tsawon wata guda yanzu, Ina son komai. Kwanan nan, an kara adadin zuwa 100 MG - ba tare da sakamako ba. Sun ce kwayoyi akan metformin sun fi tasiri, amma ya dace da ni. Don haka ina ba ku shawara. ”
Larisa: “An umurce ni da Glucobai. Likita ya yabe shi, ya ce da ita kanta ba ta haifar da cutar sankarau. Na sha kusan 50 MG na kimanin wata daya. Ina da matsaloli tare da hanji, wanda ba zan iya kawar da shi ba. Dole ne in daina waɗannan magungunan kuma na canza gaba zuwa insulin. ”
Kammalawa
Magungunan Acarbose na dauke da magunguna kodayake suna taimakawa masu ciwon suga suna hana glucose da nauyi. An tsara magunguna a lokuta da yawa, amma koyaushe a haɗe tare da wasu don kyakkyawan sakamako. Nazarin marasa lafiya da likitoci galibi tabbatacce ne, yawancin acarbose ya dace kuma yana ba da sakamako mai ɗorewa.
In sha kwayoyin hana daukar ciki?
A yawancin abubuwan glucose na al'ada, shan magungunan rage cin abinci ba shi da daraja. In ba haka ba, ya kamata a sa ido a ga sakamako masu illa ko kuma matsalolin kiwon lafiya.
Kwayoyin masu ciwon sukari suna bada shawarar shan tare da:
- 2 digiri na cutar,
- mataki na cutar
- sauran cututtukan tsokane da karuwar taro na sukari a cikin jini.
Me yasa ciwon sukari yake samun nauyi?
An lura kiba a cikin 88% na masu ciwon sukari.
A yadda aka saba, insulin na hormone yana taimakawa rage jini da kuma jigilar shi zuwa sel. Gabanin tushen ci gaban ciwon sukari, wannan tsari yana rushewa.
Kula! A mataki na 1 na cutar, an lura da juriya na insulin. Ana san wannan yanayin ta hanyar haɓaka glucose da matakan insulin lokaci guda.
Wannan yana haifar da haɓaka ƙirar sunadarai da mai kuma yana haifar da murkushe enzymes mai rarrafe mai. A kan wannan yanayin, kiba tayi girma.
Magungunan da aka ba da shawarar
Kwamfutar hannu tana nuna magungunan da ke taimakawa rage nauyi a cikin nau'in ciwon sukari na 2.
Tebur 1. Slimming kwayoyi don type 2 ciwon sukari mellitus:
| Magunguna | Bayanin |
 Metformin | Yana hana gluconeogenesis na hepatic, kuma yana taimakawa rage shayewar glucose daga hanji. Hakanan, maganin yana da alaƙa tare da ƙara yawan amfani da glucose na gefe. Tissue insulin hauhawar jini yana ƙaruwa. Jikin jikin yana kwantar da hankali ko raguwa. |
 Glucophage | Wakili mai hana haihuwa jini. Ya kasance tare da biguanides. Yana taimakawa ƙananan haɓakar glucose na hanta. Wannan yana faruwa ne akan tushen hanawar glycogenolysis da gluconeogenesis. Weight yana kwantar da hankali ko a hankali yana raguwa. |
 Siofor | Ko da kuwa tasirin tasirin glucose din jini, magungunan na da tasiri mai amfani ga metabolism. Wannan yana taimakawa rage yawan cholesterol, kazalika da triglycerides da ƙarancin ƙarancin cholesterol. |
 Metfogamma | Magungunan yana haɗuwa da raguwa a cikin LDL da triglycerides. Jin nauyin mai haƙuri ya kwantar da shi ko sannu a hankali ya dawo daidai. |
 Diaformin | Dimethylbiguanide. Mai rikitarwa tare da raguwa a cikin taro na VLDL, LDL, triglycerides. Matsayin mai haƙuri yana kwantar da shi ko ragewa cikin matsakaici. |
 Ascarbose | Alfa glucosidase inhibitor. An wajabta maganin a kan asalin yanayin rashin ingancin abinci. Hakanan, maganin na iya zama mai bugu yayin da ake shan magani tare da magani. |
Sauran magungunan slimming
Babban aikin shan magunguna don asarar nauyi shine cimma cikakkiyar iko na rayuwa da dakatar da haɗarin karuwar taro na jini.
Don asarar nauyi na sukari, ana tsara rukuni na gaba na ƙwayoyi:
- biguanides
- shirye-shiryen sulfonylurea
- glitazones
- Clinids
- alpha glucosidase inhibitors
- DPP-4 inhibitors.
Kowane rukuni na kwayoyi suna taimakawa wajen sarrafa nauyi kuma suna ba da gudummawa ga rage shi a hankali.
Biguanides da aka ba da shawarar
Magunguna a cikin wannan rukunin sunadaran sunadarai ne. Biguanides - ɗayan shahararrun kungiyoyin magunguna, sanannen tsakanin masu ciwon sukari. An tsara magunguna daga tsakiyar 50s na karni na 20.
Tebur 2. Biguanides mafi inganci:
| Magunguna | Bayanin |
 Avandamet | Oral hypoglycemic magani. A ƙarshen banbanci na glucose jini, ana lura da ci gaba a cikin sarrafawa na rayuwa. Hakanan an rage abun cikin jimlar cholesterol, TG da LDL. |
 Bagomet | Maganin yana rage jinkirin hepatic glucogenesis. Rage glucose na ciki ya ragu. Amfani da shi na glucose yana ta karuwa. Weight da amincewa normalizes ko sannu a hankali rage. |
 Metformin-Akrikhin | Magungunan yana hana gluconeogenesis, yana hana “haihuwar” kitse mai ƙoshin mai da iskar shaƙar fata. Tsarin jiki ya fara daidaitawa, sannan a hankali ya ragu. |
Kula! Magunguna na wannan rukuni suna ba da gudummawa ga halayen sakamako masu illa. Saboda haka, ana nada su ne kawai a wasu lokuta na musamman.
Mafi ingancin sulfonylureas
Babban mahimmancin magunguna na wannan rukuni shine don haɓaka ƙwayoyin beta na pancreatic don samar da insulin. An tsara magunguna lokacin da alamun bayyanar gajiya ya bayyana.
Tebur 3. Yin amfani da shirye-shiryen sulfonylurea:
| Magunguna | Yaya kamanninsa? |
 Mai ciwon sukari | Abune mai ma'anar asali na ƙarni 2. Yin amfani da miyagun ƙwayoyi yana taimakawa rage lokacin tazara daga lokacin cin abinci zuwa farkon ɓoye insulin. Yana haɗuwa da sabuntawar farkon ɓoyewar ƙwayar insulin, rage tasirin postprandial na hyperglycemia. Hakanan, maganin yana taimakawa rage yawan radicals. |
 Amaril | Magana ce ta ƙarni 3 Yana da tasirin insulinomimetic. Yana ba da gudummawa ga ƙa'idar insulin. Wannan ya faru ne sakamakon haɗakar tashoshi na tasirin potassium na ATP da membranes beta-cell. |
 A cikin hoto Glimepiride | Taimaka wajen ta da kwazo da kwantar da insulin daga kwayoyin beta. Hakanan yana da tasirin karin cutarwa. Nagari don nau'in ciwon sukari na 2. |
 Diameride (Dimexide) | Yana hana tara platelet. Wannan ya faru ne sakamakon raguwa da juyawar arachidonic acid zuwa thromboxane A2. Tasirin anti-atherogenic na maganin yana faruwa ne sakamakon raguwar abubuwan da ke tattare da malondialdehyde a cikin jini. |
 Glemaz | Yana inganta sakin insulin, yana da aikin extrapancreatic. Nagari don nau'in ciwon sukari na 2. |
An kuma tsara magunguna na wannan rukunin a cikin lokuta na musamman. Wannan ya faru ne sakamakon haɗarin hauhawar jini. Farashin magunguna ya bambanta daga 147 zuwa 463 rubles.
Glitazones da aka ba da shawarar
Magungunan sukari na rage sukari wanda aka wajabta don rage juriya insulin.
Tebur 4. Mafi ingancin glitazones:
| Magunguna | Bayanin |
 Avandaglim | Yana taimakawa haɓaka sakin insulin ta hanyar ƙwayoyin beta na lafiyayyiya. An wajabta shi don maganin haɗin gwiwa, don nau'in ciwon sukari na 2. A sakamakon haka, ana lura da haɓakar synergistic a cikin sarrafa glycemic. |
 Pioglar | Yana da ƙarfi zaɓin gamma mai karɓa agonist. Activoƙarinsu ya samo asali ne sakamakon peroxisome mai haɓakawa. Tsarin insulin a cikin yanki da kyallen hanta an daidaita shi. Tare da DM-2, an rage raguwa a cikin taro na TG da karuwa a cikin matakin HDL. |
 Diab na al'ada | Yana taimakawa rage juriya insulin a cikin kasusuwa na ciki da hanta. Ba a sanya magani ba ga nau'in ciwon sukari da ke dogaro da sukari 1 |
 Astrozone | Rashin daidaituwa tare da raguwa a cikin juriya na insulin. Wannan ya faru ne saboda ayyukan pioglitazone. A lokaci guda, ana rage glucose na jini. Hakanan ana rage matakan insulin na jini. |
 Diaglitazone | Magungunan yana taimakawa rage yawan ƙwayoyin triglycerides da kuma ƙara yawan abubuwan da ke tattare da yawan ƙwayoyin lipoproteins, har ma da cholesterol. Insulin insulin din ba ya motsawa. |
Kula! A hade tare da Metformin, kwayoyi a cikin wannan rukunin suna taimakawa rage nauyi da sauri.
Mafi Inganta Clinids
Waɗannan sune abubuwan ƙarfafa insulin. An sanya shi don sarrafa matakan sukari bayan abinci.Rage nauyi yana faruwa ne kawai idan an wajabta shi tare da maganin kashe maganin damuwa.
Tebur 5. Amfani da karuwa:
| Magunguna | Yaya kamanninsa? |
 Rana | Yana taimakawa toshe tubule masu dogaro da ATP a cikin membranes na sel sel. A tsakanin rabin awa bayan shan maganin, ana lura da amsawar insulinotropic. Wannan yana taimakawa rage yawan jini. |
 Inswada | Magana ce mai saurin motsa hanjin insulin. Yana taimakawa ƙaramin glucose na jini. Wannan ya faru ne saboda yawan ƙwayar insulin ta hanji. Hakanan, maganin yana haɗuwa tare da rufewar tubules na dogara da ATP a cikin membrane na sel sel. Don wannan, ana amfani da furotin na musamman. Sakamakon haka, tashoshin alli na bude. |
 Starlix | Kalam ne na amino acid phenylalanine. Yana haɓaka maido da ƙwayar insulin farkon. A kan wannan yanayin, yawan postprandial na glucose a cikin jini yana raguwa. Abun cikin glycated haemoglobin shima an daidaita shi. |
Shawarar Alfa Glucosidase Inhibitors
Magunguna suna taimaka rage jinkirin ƙwayar ƙwayar hanji. Wannan yana haifar da rashin yiwuwar ƙaruwa mai yawa a cikin tattarawar sukari a cikin jini. A game da tushen gudanarwa, glycated haemoglobin an daidaita shi, insulin juriya yana raguwa.
Tebur 6. Amfani da inhibitors na alpha-glucosidase:
| Magunguna | Bayanin | ||||||||||
 Acarbose | Oligosaccharide an samo shi ne daga microorganism Actinoplanes utahensis. Magungunan yana inganta rushewar di-tri - da oligosaccharides a cikin lumen na ƙananan hanji. Abun ragewa, siffofin glucose a cikin hanji. Hakanan, maganin yana da alaƙa tare da raguwa da hyperglycemia na postprandial. | ||||||||||
 Glucobay | Pseudotetrasaccharide na asalin ƙwayar cuta. Yana hana enzyme alpha glucosidase, wanda ke rushe polydi da oligosaccharides. | ||||||||||
 Miglitol | Yana taimakawa rage jinkirin kwarara zuwa cikin jini kuma ya rage glucose jini bayan cin abinci. | ||||||||||
 Diastabol | Yana haɗuwa da rage yawan hauhawar haɓaka bayan cin abinci, yana kwance bayanin martaba na glucose na sa'o'i 24. Yana taimakawa rage yawan jini a cikin jini. An rage yawan haɗuwar glycosylated haemoglobin. Magungunan ba ya shafar sha na abinci mai gina jiki. Mafi ingancin mai hanawa na enzyme DPP-4Magunguna a cikin wannan rukunin suna da tasiri a cikin kwayoyin halittar narkewar abinci. An wajabta su don sarrafa nauyin jikin mutum. Tebur 7. Amfani da inhibitors na enzyme DPP-4:
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Sitagliptin
Karshen
Linagliptin
Saxagliptin
Chromium ya dawo da hankalin insulin zuwa sel
