Yadda za a yi amfani da magani Xenical?

Form sashi - capsules: A'a 1, gelatin, turquoise, tare da tsaftataccen tsarin opaque da rubutu a baki: akan shari'ar XENICAL 120, akan filafin ROCHE, a cikin capsules - pellets of kusan fari ko farin launi (21 inji mai kwakwalwa. blisters, a cikin wani kwali na 1, 2 ko 4 blisters).

Abun da ke aiki na Xenical shine orlistat, a cikin capsule 1 - 120 mg.

Fitowa: talc.

Kayan kayan kwalliya na pellets: sitaci carboxymethyl sitaci (Primogel), celclose microcrystalline, sulfate lauryl sulfate, povidone K-30.

Abun da ke ciki na kwanson kwalliya: indigo carmine, gelatin, titanium dioxide.

Pharmacodynamics

Xenical wani takamaiman ne, mai iko, da kuma mai jujjuyarwa mai hana ƙwayar ciki, ta hanyar haɓaka sakamako. Its da warkewa sakamako ne da za'ayi a cikin lumen daga cikin karamin hanji da ciki da kuma kunshi a cikin samuwar wani covalent bond tare da aiki serine yankin na pancreatic da na ciki lipases. A wannan yanayin, enzyme wanda aka kunna ya rasa ikonsa na rushe kitsen da aka kawo tare da abinci a cikin nau'in triglycerides zuwa monoglycerides kuma yana shan kitse mai mai kyauta. Tunda triglycerides waɗanda basu da lalata a cikin jiki ba su sha, ƙarancin adadin kuzari suna shiga jiki, wanda ke haifar da raguwar nauyin jiki. Bugu da kari, an gano tasirin warkewar Xenical ba tare da shigowar abubuwanda ke cikin abubuwan da ke gudana ba.

Bayanai kan abubuwan da ke tattare da kitse suna nuna cewa orlistat ya fara aiki awanni 24 zuwa 48 bayan shigowa. Cutar da miyagun ƙwayoyi yana haifar da raguwa a cikin yawan mai a cikin feces zuwa matakin da aka rubuta kafin magani, bayan awanni 48-72.

Nazarin asibiti na marasa lafiya da ke shan Xenical sun tabbatar da cewa suna da ƙarin asarar nauyi mai yawa idan aka kwatanta da marasa lafiya waɗanda ke wajabta maganin warkewar abinci. An riga an lura da raguwar nauyin jikin mutum a cikin makonni 2 na farko bayan farawar jiyya kuma ya ɗauki watanni 6-12 har ma a cikin marasa lafiya waɗanda suka yi mummunar cutar maganin rashin abinci. A cikin shekaru biyu, an ƙididdige wani cigaba na ƙididdiga a cikin bayanan abubuwan haɗari na rayuwa tare da kiba. Hakanan, idan aka kwatanta da placebo, an lura da raguwa mai yawa a cikin kitse na jiki.

Yin amfani da orlistat yana hana sake tsarin nauyin jiki. An lura da karuwa a cikin nauyin jikin ba fiye da 25% na asarar nauyi a cikin kusan 50% na marasa lafiya, yayin da sauran suka riƙe nauyin jikin da aka kai a ƙarshen ƙarshen maganin (wani lokacin har ma an bayyana ƙarin raguwa).

Nazarin na asibiti wanda ya ƙare daga watanni 6 zuwa 1 shekara sun tabbatar da tabbaci cewa a cikin marasa lafiya tare da karuwar nauyin jiki ko kiba da nau'in ciwon sukari na 2 wanda ya dauki Xenical, nauyin jikin yana raguwa sosai fiye da marasa lafiya waɗanda aka wajabta maganin maganin kawai kamar magani . Rage nauyi yana faruwa ne sabili da rage kiba a jiki. Kafin binciken, har ma a cikin marasa lafiya da ke shan magungunan hypoglycemic, sarrafa glycemic iko bai isa ba. Koyaya, tare da maganin orlistat, an sami ci gaba a asibiti da kuma ƙididdigar haɓakawa na sarrafa glycemic. Hakanan, aikin kwantar da hankali ya haifar da raguwa a cikin taro na insulin, raguwa a cikin adadin magungunan hypoglycemic, da raguwa a cikin juriya na insulin.

Sakamakon binciken da aka gudanar a cikin shekaru 4 ya tabbatar da cewa orlistat yana rage haɗarin haɓaka nau'in ciwon sukari na type 2 mellitus (kusan 37% idan aka kwatanta da placebo). Matsakaicin raguwa a cikin yiwuwar cutar ya kasance mafi mahimmanci a cikin marasa lafiya tare da raunin glucose na farko (kusan 45%).

Nazarin asibiti wanda ya daɗe har shekara 1 kuma an gudanar dashi a cikin rukuni na marasa lafiya, masu tsufa, a fili sun nuna raguwa a cikin ƙirar jikin mutum a cikin matasa masu shan tabar wiwi idan aka kwatanta da waɗanda suka karɓi placebo kawai. Hakanan, marasa lafiya waɗanda ke shan Xenical sun nuna raguwa a cikin mai mai yawa da kewaye da kwatangwalo da kugu kuma an sami raguwa sosai a hawan jini na jini idan aka kwatanta da ƙungiyar placebo.

Pharmacokinetics

A cikin marasa lafiya da kiba da nauyin jiki na al'ada, an rage girman tasirin tsarin Xenical. Gudanar da maganin baka na maganin a cikin kashi 360 mg ba ya haifar da bayyanar orlistat wanda ba a canza shi ba a cikin plasma, wanda ke nuna cewa maida hankali bai kai matakin 5 ng / ml ba.

Ofimar rarraba orlistat kusan ba shi yiwuwa a tantance saboda ɗaukar hoto mara kyau. A cikin vitro, fili yana sama da kashi 99% zuwa hadarin plasma (galibi albumin da lipoproteins). Smallarancin adadin orlistat na iya shiga cikin membrane na erythrocyte.

Metabolism na Orlistat yana faruwa ne musamman a bango na hanji. Gwaje-gwajen sun nuna cewa kusan 42% na ƙaramar Xenical juzu'i wanda aka ƙaddamar da shi a cikin tsari shine babban metabolites biyu: M1 (ƙwararraki huɗu na hydrolyzed lactone ringi) da M3 (M1 tare da tsattsage kashi na N-formylleucine).

Molewayoyin M1 da M3 suna ɗauke da ƙarar β-lactone, kuma suna dan kadan rage girman lipase (sau 1000 da 2500 marasa ƙarfi fiye da orlistat, bi da bi). Ana amfani da waɗannan metabolites a cikin magungunan ƙwaƙwalwar ƙwaƙwalwa marasa ƙarfi saboda ƙarancin aikin inhibitory da ƙananan ƙwayoyin plasma (kamar 26 ng / ml da 108 ng / ml, bi da bi) lokacin ɗaukar Xenical a cikin ƙananan allurai.

Babban hanyar kawarda ya ƙunshi cire kayan ɗora marasa amfani tare da feces. Tare da feces, kusan kashi 97% na karɓa na Xenical an keɓe shi, tare da kusan kashi 83% ba su canzawa. Jimlar excretion na dukkan abubuwa wanda tsarinsa yana da alaƙa da orlistat bai wuce 2% na maganin ba. Zamanin cikakkiyar kawar da ƙwayoyi daga jiki (tare da fitsari da feces) kwanaki 3-5. Matsakaicin hanyoyin da za a cire abubuwa masu aiki na Xenical a cikin mutanen da ke da nauyin jiki na al'ada da kuma masu fama da kiba iri ɗaya ne. Orlistat da metabolites M1 da M3 kuma za a iya fitar dasu tare da bile. Yawan aikinsu na plasma a cikin lura da yara bai bambanta da waɗanda ke cikin manya mutane lokacin shan magunguna iri ɗaya. Yawan shafa mai na yau da kullun a lokacin jiyya tare da Xenical shine 27% lokacin shan maganin tare da abinci da kuma 7% lokacin shan placebo.

Bayanai na asibiti da nazarin dabbobi ba su gano ƙarin haɗari ga marasa lafiya ba dangane da bayanan kare lafiyar, giya mai guba, ƙwayoyin haihuwa, ƙwayoyin cuta da cutar kansa. Hakanan, ba a tabbatar da kasancewar tasirin teratogenic a cikin dabbobi ba, wanda ya sa ba zai yiwu a cikin mutane ba.

Alamu don amfani

Amfani da Xenical an nuna shi a hade tare da abinci mai ƙarancin kalori na matsakaici don maganin kiba ko kiba mai yawa, ciki har da marasa lafiya da abubuwan haɗari kama da kiba.

An wajabta magunguna ga marasa lafiya masu kiba ko masu kiba a cikin jiyya na nau'in ciwon sukari na 2 na sukari a hade tare da wakilai na hypoglycemic: insulin, metformin, sulferilurea Kalam ko kuma rage cin abinci mai kalori mai dan kadan.

Contraindications

Cholestasis
Cutar malavesorption na kullum,
Lokacin daukar ciki da shayarwa,
Hypersensitivity ga abubuwan da ke cikin miyagun ƙwayoyi.

Ba a bincika aminci da tasiri na miyagun ƙwayoyi a cikin marasa lafiya da ke fama da rauni na aiki da hepatic, tsofaffi marasa lafiya da yara waɗanda shekarunsu ba su 12 ba su bincika.

Umarnin don amfani da Xenical: hanya da sashi

Ana ɗaukar capsules a baki, yayin ko kai tsaye (a cikin awa 1) bayan cin abinci.

Shawarar sashi: 1 kwantena sau 3 a rana, a lokacin kowace abinci.

Idan abincin ba ya ƙunshi kitse ko mara lafiya ya tsallake karin kumallo, abincin dare ko abincin rana, to, ana rage yawan abincin yau da kullun ta hanyar abincin da aka tsallake.

Abincin mai haƙuri mai sauƙi, mai matsakaici mai ƙarancin kalori ya kamata ya ƙunshi kitse 30%. Abincin kalori na yau da kullun, wanda ya ƙunshi mai, furotin da carbohydrates, ya kamata a raba manyan hanyoyin guda uku.

Side effects

A cikin karatun asibiti game da amfani da Xenical, halayen da ba a sani ba sun faru:

Daga cikin jijiyoyin mahaifa: sau da yawa - m karfi don dishewa, cirewa daga farfajiyar wani mai mai, steatorrhea, narkewa da iskar gas tare da zubarda maras amfani, haɓaka hanjin motsi, shimfidar kwance, rashin jin daɗi ko jin zafi a cikin ciki, ƙwanƙwasawa (ƙarancin yana ƙaruwa da haɓaka mai mai a abinci), sau da yawa - bloating, m stools, fecal incontinence, pain ko rashin jin daɗi a cikin dubura, lalacewar hakora da / ko gumis,
Sauran: sau da yawa - ciwon kai, cututtukan hanji na sama, mura, sau da yawa rauni, dysmenorrhea, damuwa, urinary da ƙananan ƙwayar jijiyoyin jiki, a cikin marasa lafiya da nau'in ciwon sukari na 2 na cututtukan jini - yanayin hypoglycemic.

A cikin lura bayan tallace-tallace, za a iya bayyana yanayin lahanta sakamako:

Allergic halayen: da wuya - itching, fatar fata, bronchospasm, urticaria, anaphylaxis, angioedema, da wuya - rauni mai ƙarfi,
Sauran: da wuya - ƙarancin aiki na alkaline phosphatase da transaminases, hepatitis, zazzabin fitsari, diverticulitis, pancreatitis, cholelithiasis da oxalate nephropathy (ba a san yawan lokacin da ya faru ba).

Yawan damuwa

Nazarin asibiti wanda mutane masu nauyin jiki na yau da kullun da masu fama da kiba suka shiga, waɗanda suka ɗauki kashi ɗaya na 800 MG ko an yi musu magani tare da Xenical na kwanaki 15 kuma sun karɓa da nauyin 400 MG sau 3 a rana, ba su tabbatar da faruwar manyan abubuwanda ke faruwa ba. Hakanan, a cikin marasa lafiya suna shan orlistat 240 MG sau 3 a rana don watanni 6, babu manyan matsalolin kiwon lafiya.

Don haka, tare da yawan abin sha game da Xenical, abubuwan da suka faru suna haɗari ko dai ba su da kama ko waɗanda aka yi rikodin tare da amfani da miyagun ƙwayoyi a allurai. Tare da ambaton ƙwayar yawan ƙwayar cuta, an bada shawarar a kula da yanayin haƙuri har tsawon awanni 24. Dangane da binciken da aka yi a cikin dabbobi da mutane, duk tasirin tsarin da ke tattare da kayan lipase-inhibiting na Orlistat ana iya canzawa da sauri.

Umarni na musamman

Dangane da umarnin, Xenical tare da tsawaita amfani yana ba ku damar sarrafa raguwa da kiyaye nauyin jikin mutum a sabon matakin, yana hana karuwar maimaita karin fam.

Haɓaka da shawarar da aka bayar na Orlistat baya inganta tasirin warkewarta.

Tasirin asibiti na miyagun ƙwayoyi yana rage adadin mai mai visceral kuma yana inganta bayanan abubuwan haɗari da cututtukan da ke haɗuwa da kiba, ciki har da haƙuri mai narkewa, nau'in ciwon sukari na 2, hyperinsulinemia, hypercholesterolemia, hauhawar jini.

Gudanar da magani na lokaci daya tare da wakilai na hypoglycemic (abubuwan da ke haifar da maganin sulfonylurea, metformin, insulin) da kuma rage yawan abinci na hypocaloric na rage yawan marasa lafiya da ke dauke da ciwon sukari na nau'in 2 tare da kiba ko kiba don ci gaba da biyan diyya na metabolism metabolism.

A cikin mafi yawan marasa lafiya, bayan shekaru huɗu na amfani da orlistat, nazarin asibiti ya tabbatar da abun ciki na betacarotene da bitamin A, D, E, K a cikin kewayon al'ada.Da samar da jiki tare da wadataccen wadataccen abinci mai gina jiki, ana nuna magungunan ƙwayoyin cuta.

Ya kamata a daidaita tsarin abinci na hypocaloric na yau da kullun, ya ƙunshi yawancin 'ya'yan itatuwa da kayan marmari da 30% ko lessasa da adadin kuzari a cikin fats. Ya kamata a ci abinci na yau da kullun na carbohydrates, fats da sunadarai a cikin manyan allurai uku.

Yiwuwar sakamako masu illa na miyagun ƙwayoyi daga ƙwayar gastrointestinal yana ƙaruwa akan asalin abinci mai mai.

Yin amfani da Xenical a cikin nau'in 2 na ciwon sukari mellitus yana inganta diyya na metabolism metabolism kuma yana iya haifar da buƙata don rage yawan adadin wakilai na hypoglycemic.

Haihuwa da lactation

Karatuttukan cututtukan dabbobi masu cutar dabbobi ba su bayyana tasirin teratogenic da amfrayo na Xenical ba. An ɗauka cewa maganin bashi da lafiya ga mata masu juna biyu, duk da haka, saboda ƙarancin bayanan da aka tabbatar a asibiti, ba a ba da shawarar gudanarwarsa ba a wannan lokacin. Ba a san daidai ba ko orlistat ya shiga cikin madara, saboda haka dole ne a dakatar da shayarwa yayin magani.

Hulɗa da ƙwayoyi

Babu wata hulɗa ta asibiti ta Xenical tare da amfani da amitriptyline na lokaci guda, atorvastatin, biguanides, digoxin, fibrates, fluoxetine, losartan, phenytoin, rigakafi na baka, phentermine, pravastatin, warfarin, nifedipine, magungunan ƙwayar cuta, da kuma magunguna marasa magani. Koyaya, idan aka haɗa shi da maganin anticoagulants na baki, gami da warfarin, ana yaba cewa za'a kula da alamun daidaitattun ƙasashe na duniya (INR).

Akwai raguwa a cikin sha na betacarotene da bitamin D, E, don haka yakamata a ɗauki multivitamins kafin lokacin bacci ko 2 sa'o'i bayan shan maganin.

Haɗuwa tare da cyclosporine na iya haifar da raguwa a cikin maida hankali a cikin jini na jini, saboda haka, ya zama dole don ƙayyadadden abubuwan da ke cikin plasma na cyclosporine yayin haɗuwa tare da orlistat.

Sakamakon karancin karatun magunguna, amfanin acarbose na lokaci daya ya tazara.

A ƙarshen asalin aikin kulawa da magunguna na Xenical da antiepileptic, an yi rikodin maganganun ci gaban mawuyacin haƙuri a cikin haƙuri. Tunda ba a kafa dangantakar abokantaka ta wannan hulda ba, ya kamata a sanya ido sosai da kuma yawan zafin cutar a cikin wannan rukuni na marasa lafiya.

Analogues na Xenical sune: Xenalten, Orsoten, Orsotin Slim, Orlistat Canon, Alli, Orlimaks.

Ra'ayoyi game da Xenical

Dangane da sake dubawa, Xenical yana haifar da halin damuwa a cikin marasa lafiya. Yawancinsu suna jayayya cewa amfani da shi zai yi tasiri kawai a cikin batun cikakken yaƙi a kan matsalar ƙimar nauyi.

Yawancin likitoci sun yi imanin cewa miyagun ƙwayoyi taimako ne mai kyau a cikin magance kiba, amma tilas ya zama dole a haɗe shi da abincin mai-mai. A cikin watan 1 na jiyya tare da Xenical, koda ba tare da babban iko da aikin jiki ba, zaku iya rasa kilogiram 1.5-2. Ko da mafi kyawun sakamako ana samun su ta hanyar haɗuwa da irin wannan maganin ƙwaƙwalwa tare da wasanni.

Ya danganta da yanayin jikin mutum da lura sosai da kuma rubutaccen likitan likitanci, zai yuwu a rage nauyin jikinsa da kilogiram na 10-15 a cikin watanni 3, kuma da nauyin 30 a cikin watanni 6.

Ta yaya miyagun ƙwayoyi ke aiki?

Ta yaya miyagun ƙwayoyi Xenical don asarar nauyi? Ana samun tasirin magungunan ta hanyar rage lipase, wanda suke cikin jijiyoyin ciki, wanda ke haifar da jinkirin nauyi saboda ƙoshin mai. Abubuwan da ke aiki suna ɗaukar kitsen mai wuce haddi kuma suna cirewa daga jiki a wata hanya ta zahiri. Saboda wannan tsari, feces suna da cikakkiyar jelly mai kamshi.Jikin kowace rana yana fara samun karancin kitse kimanin kashi 30%, wanda hakan ke tilasta shi yin amfani da kayan sa, watau, narke kitse mai kiba.

Idan ka bi tsarin karancin kalori da karancin abinci mai kiba, sakamako masu illa akasin haka kada ka dame mutum.

Idan ba a lura da wannan abin ba, ana iya lura da wannan sakamako masu illa a cikin marasa lafiya:

matsanancin sako-sako
rashin daidaituwa
Karin kuzarin yin nasara,
matsanancin gas
rashin jin daɗi a cikin dubura ko hanjinsu,
fitarwa mai mai daga dubura, koda kuwa a cikin nutsuwa ne.

A matsayinka na mai mulki, duk waɗannan bayyanuwar suna bayyana ne kawai a farkon lokacin ɗaukar hanya don rasa nauyi kuma sun ɓace lokacin daidaita tsarin abincin, kamar yadda aka gani ta hanyar nazarin da yawa na waɗanda suka rasa nauyi.

Yadda ake ɗaukar shi daidai?

Xenical don asarar nauyi yadda zaka ɗauki daidai?

Kafin ɗaukar Xenical, mai haƙuri yana buƙatar karanta umarnin kuma kada ya keta umarnin sa, in ba haka ba haɗarin cutarwa mara kyau yana yiwuwa.

Allunan za'a iya sha sau uku a rana tare da abinci ko kuma bayan shi., amma ba daga baya ba cikin awa daya, don haka tasirin ba zai sake kasancewa ba saboda gaskiyar cewa ƙashin mai mai shigowa yana da lokaci don ɗaukar jiki. Idan saboda wasu dalilai baza ku iya ɗaukar capsule a lokacin da aka tsara ba, zai fi kyau tsallake kashi ɗaya. Ya kamata a tuna cewa kuna buƙatar sha kwamfutar hannu tare da cikakken gilashin ruwa don cimma sakamako mafi ma'ana. Idan a cikin ɗayan abincin babu cikakken mai, yana da kyau a ƙi shan magani.

Hanya na kulawa da capsules don asarar nauyi shine watanni 2 tare da cin abincin yau da kullun na allunan 1-3. Yawancin masana ilimin abinci sun ba da shawara game da shan ƙwayar Xenical kawai bayan waɗancan abincin da suke da wadataccen mai, a wasu halayen, tsallake don kauce wa sakamako masu illa.

Bayan nazarin yawancin sake dubawa na marasa lafiya waɗanda suka dauki Xenical, likitoci sun lura da fa'idar amfani da maganin da kuma daidaitawar nauyi bayan watanni da yawa. A matsakaici, a cikin 'yan watanni na farko, nauyin mara nauyi ya ragu da kashi 10-20%, a ƙarƙashin duk ƙarin shawarwari.

Mafi sau da yawa, ban da Xenical, likita ya tsara magungunan da ke mayar da metabolism a cikin jiki, tunda a mafi yawan lokuta tare da kiba yana da illa. Sabili da haka, waɗanda suka rasa nauyi tare da taimakon wannan magani ba wai kawai sun cika duk umarnin da aka tsara ba, har ma sun sha wasu magunguna don inganta narkewar abinci. Mafi sau da yawa wannan shine fiber na fiber, wanda ke taimakawa haɓaka tasiri na Xenical.

Dangane da shaidu daga mutanen da suka sha gaba dayan karatun, sun sami nasarar rasa matsakaicin nauyin kilogram 2-3 a wata, yayin da alamu marasa dadi ba sa tare da su. Haka kuma, kusan dukkanin marassa lafiya sun lura cewa sun manta da maƙarƙashiyar da ke tare da su na dogon lokaci.

Aikin magunguna

Xenical wani takamaiman hanawa ne na hana ƙwayoyin gastrointestinal tare da sakamako mai dorewa. Its da warkewa sakamako ne da za'ayi a cikin lumen na ciki da ƙananan hanji da kuma kunshi a cikin samuwar wani covalent bond tare da aiki serine yankin na na ciki da kuma pancreatic lipases. A wannan yanayin, enzyme wanda aka kunna ya rasa ikonsa na rushe kitsen abinci a cikin nau'in triglycerides zuwa cikin mayukan kitse mai narkewa da monoglycerides. Tunda ba a shanyewar triglycerides marasa amfani, sakamakon raguwar yawan adadin kuzari yana haifar da raguwar nauyin jiki. Saboda haka, warkewa sakamako na miyagun ƙwayoyi ana aiwatar da shi ba tare da ɗauka cikin jini ba.

Yin hukunci da sakamakon mai mai a cikin feces, sakamakon orlistat yana farawa awanni 24-48 bayan fitowar. Bayan dakatar da maganin, mai mai a cikin feces bayan sa'o'i 48-72 yawanci yakan dawo zuwa matakin da ya faru kafin a fara maganin.

Haihuwa da lactation

A cikin nazarin nazarin halittar dabbobi, ba a lura da teratogenic da amfanuwa da maganin ƙwayar cuta ba. Idan babu tasirin teratogenic a cikin dabbobi, za a yi tsammanin irin wannan sakamako a cikin mutane. Koyaya, saboda ƙarancin bayanan asibiti, bai kamata a rubuta Xenical ga mata masu juna biyu ba.

Ba a bincika haɓakar Orlistat tare da madara nono, saboda haka, bai kamata a sha shi lokacin shayarwa ba.

Sashi da gudanarwa

A cikin manya, shawarar da aka bayar da maganin orlistat shine maganin kawancin ƙwayoyin cuta guda ɗaya na 120 tare da kowane babban abinci (tare da abinci ko a'a bayan sa'a ɗaya bayan cin abinci). Idan abincin ya tsallake ko kuma idan abincin bai ƙunshi kitse ba, to Xenical shima za'a iya tsallake shi.

Anara yawan kashi na orlistat akan shawarar (120 mg sau 3 a rana) baya haifar da gashin baki

zubar da warkewa sakamako.

Ba a buƙatar daidaitawa na tsufa a cikin marasa lafiya tsofaffi.

Gyaran gyaran jiki don hanta mai rauni ko aikin koda baya buƙatar.

Ba'a tabbatar da aminci da tasiri na Xenical a cikin yara 'yan ƙasa da shekaru 18 ba.

Side sakamako

Abubuwan da ba su dace ba ga Orlistat ya faru ne musamman daga maƙarƙashiyar ciki kuma sun kasance saboda aikin magunguna na maganin, wanda ke rikicewa tare da ɗaukar kitsen abinci. Sau da yawa, abubuwan mamaki kamar fitowar mai daga dubura, gas tare da wani adadin ɗin ruwa, yawan motsa jiki don magance, ƙwayar jijiyoyin jiki, haɓaka yawan motsin hanji da rashin daidaituwa na zuciya.

Yawan su yana ƙaruwa tare da haɓakar mai a cikin abincin. Ya kamata a sanar da marasa lafiya game da yiwuwar mummunan sakamako daga cututtukan gastrointestinal kuma a koyar da yadda ake kawar da su ta hanyar cin abinci mafi kyau, musamman dangane da yawan kitse da ke ciki. Abincin mai mai kitse yana rage haɗarin sakamako masu illa daga ƙwayar jijiyoyi kuma yana taimaka wa marasa lafiya don sarrafawa da daidaita yawan mai.

A matsayinka na mai mulkin, waɗannan halayen masu haɗari suna da laushi da sassauci. Sun faru ne a farkon matakan kulawa (a cikin watanni 3 na farko), kuma yawancin marasa lafiya basu da fiye da ɗayan ɗayan irin waɗannan halayen.

A cikin lura da Xenical, abubuwan da suka faru na wulakanci daga cikin jijiyoyin ciki suna faruwa sau da yawa: jin zafi ko rashin jin daɗi a cikin ciki, ƙwanƙwasawa, shimfidar kwance, “shimfidu” mai laushi, jin zafi ko rashin jin daɗi a cikin dubura, lalacewar haƙori, cutar gum.

Hakanan an lura da cututtukan cututtukan zuciya na sama ko na huhu, mura, ciwon kai, dysmenorrhea, damuwa, rauni, da cututtukan hanji.

Ba a bayyana yanayin halayen halayen rashin lafiyan ba, alamomin babban asibiti wanda ya kasance itching, fitsari, urticaria, angioedema da anaphylaxis.

A cikin marasa lafiya da ke da nau'in ciwon sukari na 2 na sukari, yanayin da muguwar haɗari sun kasance daidai da waɗanda ke cikin mutane ba tare da ciwon sukari ba tare da kiba da kiba. Sabbin sababbin sakamako masu illa waɗanda suka faru tare da yawan '2% da> 1%, idan aka kwatanta da placebo, sune yanayin hypoglycemic (wanda zai iya haifar da ingantaccen diyya don metabolism metabolism) da bloating.

Yin hulɗa tare da wasu kwayoyi

A cikin karatun pharmacokinetic, hulɗa tare da barasa, digoxin, nifedipine, maganin hana haihuwa, phenytoin, pravastatin, ko warfarin ba a lura dasu ba.

Tare da gudanarwa na lokaci guda tare da Xenical, an lura da raguwa a cikin sha na bitamin A, D, E, K da beta-carotene. Idan ana bada shawarar multivitamins, sai a dauki su kasa da awanni 2 bayan shan Xenical ko kafin a kwanta bacci.

Tare da kulawa na lokaci daya na Xenical da cyclosporine, an lura da rage yawan ƙwayar cutar plasma na cyclosporine, sabili da haka, ana buƙatar ƙarin ƙaddara yawan kwarincin cyclosporine tare da kulawa na lokaci daya na cyclosporine da Xenical.

Siffofin aikace-aikace

Xenical yana da tasiri dangane da kulawa na tsawon lokaci na nauyin jiki (rage nauyin jikin mutum da kiyayewarsa a wani sabon matakin, rigakafin samun karin nauyi). Kulawa na Xenical yana inganta bayanan abubuwan haɗari da cututtukan da ke da alaƙa da kiba, ciki har da hypercholesterolemia, nau'in ciwon sukari na 2 na jini (NIDDM), rashin haƙuri na glucose, hauhawar hyperinsulinemia, hauhawar jini, da kuma rage kiba a cikin ƙwayar visceral.

Lokacin da aka yi amfani dashi a hade tare da magunguna masu rage sukari kamar metformin, sulfonylureas da / ko insulin a cikin marasa lafiya da nau'in sukari na 2 na sukari wanda ya wuce kiba (BMI> 28 kg / m 2) ko kiba (BMI> 30 kg / ^) Xenical, haɗe tare da tsarin abinci na hypocaloric na ɗan lokaci, yana samar da ƙarin ci gaba a cikin biyan bashin metabolism.

A cikin gwaji na asibiti a cikin mafi yawan marasa lafiya, yawan abubuwan bitamin A, D, E, K da beta-carotene yayin tsawon shekaru biyu na maganin tare da orlistat ya kasance cikin kewayon al'ada. Don tabbatar da isasshen wadataccen abinci mai gina jiki, ana iya tsara magunguna masu yawa.

Yakamata mai haƙuri ya sami madaidaicin, matsakaiciyar hypocaloric rage cin abinci maras nauyi fiye da 30% adadin kuzari a cikin nau'i na mai. Ana bada shawarar rage cin abinci mai yalwar 'ya'yan itatuwa da kayan marmari. Dole ne a raba kitse na yau da kullun, carbohydrates da sunadarai zuwa manyan hanyoyin guda uku.

Yiwuwar halayen da ke tattare da haɗari daga ƙwayar gastrointestinal na iya ƙaruwa idan an dauki Xenical tare da abincin da ke da ƙoshin mai (alal misali, 2000 kcal / rana, wanda fiye da 30% yana cikin fats, wanda yayi daidai da 67 g na mai). Ya kamata a mai da abincin yau da kullun zuwa kashi uku na allurai. Idan an dauki Xenical tare da abinci mai wadataccen mai mai yawa, yiwuwar halayen gastrointestinal yana ƙaruwa.

A cikin marasa lafiya da ke da nau'in ciwon sukari na 2 na sukari, raguwa a cikin nauyin jiki yayin jiyya tare da Xenical yana haɗuwa tare da haɓakawa game da diyya na metabolism, wanda zai iya ba da izinin ko buƙatar raguwa a cikin adadin magunguna masu rage sukari.