Lozap ko Lorista

Wanne magani ya fi kyau: Lozap ko Lorista? Dukkanin magunguna suna da rawar gani iri-iri, amma babban dalilin su shine rage hawan jini. Don gano bambance-bambance tsakanin magunguna da kuma tantance wanne yafi tasiri a cikin magance cutar hawan jini, kuna buƙatar bambance umarnin don Lozapa da Lorista, tare da tuntuɓar ƙwararrun masani don ɗaiɗa zaɓi sashi kuma tsaida tsawon lokacin.

MUHIMMI ZAI KYAUTA! Tabakov O. "Ba zan iya ba da shawarar guda ɗaya kawai don magance matsin lamba ba cikin sauri" karanta a.

Abun ciki da aiki

Magunguna "Lorista" da "Lozap" sun ƙunshi losartan azaman aiki mai aiki. Karin kayan aikin "Lorista":

• sitaci
• ƙari abinci E572,
• zaren
• cellulose
• ƙarin abinci na abinci E551.

Substancesarin abubuwa a cikin samfurin magani "Lozap" sune kamar haka:

• sabbinne,
• makarin sodium,
• MCC
• povidone
• ƙari abinci E572,
• mannitol.

Aikin na’urar kiwon lafiya ta Lozap an yi niyya ne don rage karfin jini, janar gaba daya na tasoshin jini, da rage kaya a zuciya, tare da kawar da yawan ruwa da fitsari a jiki tare da fitsari. Magungunan yana hana hauhawar myocardial hauhawar jini kuma yana ƙaruwa da jimiri na jiki a cikin mutanen da ke fama da rauni na aiki na jijiyoyin zuciya. Lorista yana toshe masu karɓar masu karɓa na AT II a cikin kodan, zuciya, da jijiyoyin jini, wanda ke taimakawa rage takaitaccen ƙwayar jijiya, ƙananan OPSS, kuma, sakamakon haka, ƙananan ƙimar haɓakar jini.

Manuniya da contraindications

Shirye-shirye dangane da losartan ana bada shawara don amfani da waɗannan halaye:

An contraindicated yin amfani da shirye-shirye na magani dauke da guda aiki losartan a cikin mata a cikin matsayin reno uwaye, a cikin yara a karkashin shekaru 18, da kuma da wadannan pathologies:

• karancin jini
• high matakan potassium a cikin jini,
• bushewa
• mutum mai haƙuri da magani,
• rashin maganin lactose.

Sauran analogues

Idan saboda wasu dalilai ba zai yiwu a yi amfani da "Lozap" da "Lorista" ba, likitoci suna ba da alamun analogues:

• Brozaar
• Karzartan
• Lakea
• Bugawa
• "Lozarel"
• Presartan
• Zisakar
• Losacor
• Vazotens
• "Renicard"
• Cozaar
• "Lotor".

Kowane magani, wanda shine kwatancen Lorista da Lozapa, yana da nasa umarnin don amfani, wanda ke nufin cewa yakamata a sha shi ne kawai bayan tattaunawa tare da babban likita wanda ya tsara tsarin kulawa dashi daban-daban ga kowane mara lafiya. Tare da shan magungunan kai, haɗarin haɓaka alamun bayyanar cututtuka yana ƙaruwa sosai.

Gabaɗaya halaye

Dukansu magunguna suna dogara ne akan losartan, wanda ke tsokani babban zaɓi - tasirin nau'in mai gani a bayyane masu karɓar karɓaɓɓu, ba tare da cutar da sauran ayyukan jikin mutum ba, wanda ke haɓaka matakan aminci. Akwai shi a cikin nau'ikan allunan, wanda ke tsoratar da kyakkyawan tsarin liyafar. Abubuwan da ke aiki ba su tasiri metabolism na carbohydrates da lipids, wanda ke ba da damar yin amfani da kwayoyi har ma da ciwon sukari. Ba a amfani da magunguna biyu a cikin ilimin yara.

Menene bambance-bambance?

Lozap a matsayin wani ɓangare na ƙarin kayan abinci ba ya ƙunshi lactose, wanda ke tsoran yiwuwar amfani dashi idan akwai rashin haƙuri ga wannan kayan.

Lorista yana samuwa a cikin nau'ikan allunan, amma tare da magunguna daban-daban (tare da abubuwa daban-daban na abubuwan da ke aiki), wanda ke ba ku damar zaban sashi don wannan ko cutar.

Idan mara lafiyar yana da rashin haƙuri na lactose, to an wajabta Lozap. A wasu halayen, likitan na iya yin wasiyya ɗaya ko ɗaya miyagun ƙwayoyi, tun da suke daidai ne a cikin abubuwan da aka tsara da kuma saitin contraindications. An wajabta don hauhawar jini, a matsayin rigakafin faruwar cututtukan zuciya, da tasoshin jini, a cikin yanayin ƙarancin ƙwaƙwalwar zuciya, harma da lalacewar tasoshin koda (a cikin ciwon sukari).

Sau da yawa, marasa lafiya suna nuna cewa an fi son Loriste saboda yawancin nau'ikan sashi na abubuwan da ke aiki a cikin allunan, wanda ke sa shan magani ya zama mai sauƙi. Amma dole ne a ɗauka a zuciya cewa wannan magani yana da sigogi na farashin mafi girma. An wajabta shi don hauhawar jini, a matsayin wani abu na hana bugun jini, idan har zuciya ta yi rauni.

Halin halin Lozap

Magungunan yana da halaye masu zuwa:

1. Abun ciki da nau'i na saki. Lozap an yi shi a cikin nau'ikan allunan wanda aka lullube shi da fim mai narkewa fari ko launin shuɗi mai launi mai kyau. Abun da ke cikin magungunan sun hada da 12.5 ko 50 MG na potassium losartan, cellulose na crystalline, mannitol, silicon dioxide, magnesium stearate, hypromellose, macrogol. Allunan an cika su a blisters na 10 inji mai kwakwalwa. Akwatin kwali ya ƙunshi sel 3, 6 ko 9.
2. Aikin magunguna. Magungunan yana rage hankalin mai karɓar angiotensin ba tare da hana ayyukan kininase ba. A kan tushen ɗaukar Lozap, juriya na tasoshin yanki, matakin adrenaline a cikin jini da hauhawar jini a cikin jijiyoyin huhu yana raguwa. Potsalensa fosartan yana da sakamako mai laushi mai sauƙi. An bayyana sakamako mai kyau na miyagun ƙwayoyi akan tsarin jijiyoyin jini a cikin rigakafin lalacewar tsoka da ci gaba a cikin rayuwar rayuwar marasa lafiya da cututtukan zuciya.
3. Pharmacokinetics Abubuwan da ke aiki da sauri suna shiga cikin jini, lokacin da ta farko ta ratsa hanta, sai ta canza zuwa metabolite mai aiki. Matsakaicin losartan da samfuransa na plasma an ƙaddara su minti 60 bayan gudanarwa. Kashi 99% na abubuwa masu aiki sun danganta ga furotin jini. Abubuwan baya ƙetare katangar-kwakwalwa. Losartan da metabolites din an kebe su a cikin fitsari.
4. Zaman aikace-aikace. Ana amfani da miyagun ƙwayoyi a matsayin wani ɓangare na hadaddun hanyoyin kwantar da hankali don hauhawar jijiya da rauniwar zuciya. Magungunan yana taimakawa rage haɗarin haɓaka haɗarin haɗarin bugun jini da hauhawar ventricle hagu. Yana yiwuwa a yi amfani da Lozap don cutar sanƙuwar mahaifa, tare da haɓaka matakin creatinine da furotin a cikin fitsari.
5. Contraindications Ba'a amfani da miyagun ƙwayoyi yayin daukar ciki, lactation da rashin haƙuri ɗaya daga cikin abubuwan. Ba a kafa tasiri da amincin magungunan rigakafi ga yara ba. Tare da taka tsantsan, ana amfani da Lozap don maganin tsoka, ragi a cikin ragewar yaduwar jini, take hakkin ma'aunin ruwa, guntuwar hanji, da kuma hanta mai rauni.
6. Hanyar aikace-aikace. Ana amfani da Allunan ban da abinci sau 1 a rana. Sashi ne m da irin da yanayin hanya na cutar. Ana rage kashi ɗaya na yau da kullun tare da yin amfani da Lozap a haɗaka tare da diuretics da sauran magungunan antihypertensive. Jiyya yana gudana har zuwa raguwar ciwan jini.
7. Abubuwan da ba a so. Yawan tsananin tasirin sakamako ya dogara da kashi ana gudanarwa. Abubuwan da suka fi dacewa da jijiyoyin jijiya (cututtukan asthenic, rauni gaba ɗaya, ciwon kai), raunin narkewa (zawo, tashin zuciya da amai) da bushewar tari. Allergic halayen a cikin nau'in urticaria, itching fata da rhinitis ne ƙasa da na kowa.

Halayen Lorista

Lorista yana da halaye masu zuwa:

1. Fom ɗin saki. Magungunan suna cikin nau'ikan allunan, masu shiga ciki tare da launin shuɗi.
2. Abun ciki Kowane kwamfutar hannu ta ƙunshi 12.5 MG na potassium losartan, cellulose foda, madara sukari monohydrate, sitaci dankalin turawa, dioxide silicon dioxide, alli stearate.
3. Aikin magunguna. Lorista yana cikin magungunan antihypertensive na rukuni na nonpeptide angiotensin recepor blockers. Magungunan yana rage mummunan haɗari na nau'in angiotensin 2 akan tasoshin jini. Yayin shan magungunan, akwai raguwa a cikin haɗin aldosterone da canji a cikin juriya. Wannan yana ba da damar amfani da Lorista don hana ci gaban bugun jini da bugun zuciya da ke da alaƙa da aiki da jijiyoyin zuciya. Magungunan yana da tasiri na tsawan lokaci.
4. Tsotsa da rarrabawa. Lokacin da aka sha shi a baki, abu mai aiki da sauri yana shiga cikin jini. Jiki yana ɗaukar kusan 30% na kashi na sarrafawa. A cikin hanta, losartan an canza shi zuwa aiki na metabolite carboxy. An gano ƙwayar warkewa na abu mai aiki da samfurin ƙwaƙwalwarsa a cikin jini bayan sa'o'i 3. Cire rabin rayuwa yana yin awa 6-9. Ana amfani da Metabolites na losartan a cikin fitsari da feces.
5. Alamu don amfani. Ana amfani da magungunan don rage haɗarin mace-mace a cikin marasa lafiya da ke fama da hauhawar jini da kuma cututtukan zuciya. Ana iya amfani da Lorista ta hanyar marasa lafiya da masu ciwon sukari mellitus tare da furotin mai ƙarfi.
6. Taƙaitawa kan amfani. Ba za a iya amfani da wakili na rigakafin ƙwayar cuta ba a lokacin daukar ciki da lactation, halayen rashin lafiyar jiki ga losartan da ƙuruciya (har zuwa shekaru 18).
7. Hanyar aikace-aikace. A shawarar da aka bada shawarar yau da kullun shine 50 MG. Ana shan miyagun ƙwayoyi sau ɗaya da safe. Bayan daidaita al'ada na jini, an rage kashi zuwa kashi na kulawa (25 MG kowace rana).
8. Side effects. Matsakaici da babban allurai na losartan na iya haifar da raguwa mai yawa a cikin karfin jini, tare da yawan farin ciki, raunin tsoka da kuma jijiyoyin jiki. Tasirin mummunar magungunan a kan narkewar abinci yana bayyana ta zawo, tashin zuciya da amai, jin zafi a ciki, haɓaka ayyukan hanta na hanta. A cikin halayen da ba kasafai ba, halayen rashin lafiyan yakan faru ne ta hanyar kumburin fuska da maƙogwaron.

Kwatanta Miyagun Kwayoyi

Lokacin da aka gwada halayen magungunan antihypertensive, duka abubuwa biyu ne na yau da kullun.

Abubuwan da ke tattare da kwayoyi suna cikin halaye masu zuwa:

• duka Lozap da Lorista suna cikin rukunin masu karɓar tallafin angiotensin,
• magunguna suna da jerin lambobi iri ɗaya don amfani,
• duk magungunan suna dogara ne akan losartan,
• Akwai wadatar kuɗi a cikin kwamfutar hannu.

Ra'ayoyin likitocin zuciya

Svetlana, dan shekara 45, Yekaterinburg, likitan zuciya: “Lozap da analog Lorista suna da kyau a fannin aikin zuciya. An yi amfani dasu don kula da hauhawar digiri na farko .. Yin shan magunguna yana taimaka wajan hanzarta magance hawan jini .. Allunan sun dace don amfani, ya isa ya ɗauka don kawar da alamun cutar hauhawar jini. Sau 1 a rana. Abubuwanda ke haifar da rauni suna da matukar wahalar gaske. "

Elena, mai shekara 34, Novosibirsk, likitan zuciya: “Lorista da Lozap sune masu aikin kwantar da hankali wanda ke da tasirin sauki .. Suna sassauyawan hawan jini ba tare da haifar da ci gaban orthostatic ba sabanin jiyya mai rahusa don hauhawar jini, wadannan magungunan ba sa haifar da bushewa. yana taimakawa wajen cire ruwa mai yalwa ba tare da rikitar da daidaitattun-gishiri-ruwa ba. Lorista ya ƙunshi lactose, don haka don rashi lactase, ya kamata a zaɓi Lozap.

Nazarin haƙuri game da Lozap da Lorista

Eugenia, 38 years old, Barnaul: "Gabanin yanayin damuwa, hawan jini ya fara ƙaruwa. Likitan likitan ya ba da umarnin Lozap. Na sha allunan da safe, wanda ke hana bayyanar ciwon kai da sauran alamomin mara kyau na hawan jini .. Hakanan magunguna yana da isasshen analog - Lorista. Na gwada waɗannan magungunan. amma, sun tabbatar da rashin inganci. "

Kasuwancin Lozap

Nau'i na saki - Allunan. Za'a iya siyan magungunan a cikin kantin magani na 30, 60 da 90 guda a kowane fakiti. Babban sinadaran aiki a cikinsu shine losartan. Kwamfutar hannu 1 na iya ƙunsar 12.5, 50 da 100 MG. Bugu da kari, akwai mahadi masu taimakawa.

Shirye-shiryen Lozap da Lorista sune analogs kuma suna cikin rukuni ɗaya na kungiyar magunguna - angiotensin 2 antagonists.

Sakamakon magungunan Lozap yana nufin rage karfin jini. Bugu da kari, miyagun ƙwayoyi suna rage juriya gaba ɗaya. Godiya ga kayan aiki, ana rage nauyin a kan ƙwayar zuciya. Ana fitar da ruwa mai yawa da gishiri a jiki tare da fitsari.

Lozap yana hana damuwa a cikin aikin myocardium, hauhawar jini, yana ƙara ƙarfin zuciya da jijiyoyin jini zuwa aikin jiki, musamman a cikin mutanen da ke fama da cututtukan ƙwayar cuta na wannan sashin.

Rabin rayuwar mai aiki shine daga 6 zuwa awa 9. Kusan 60% na metabolite mai aiki ana fito dasu tare da bile, sauran kuma tare da fitsari.

Alamu don amfanin Lozap sune kamar haka:

• hauhawar jini
• na kullum zuciya
• rikitarwa na nau'in ciwon sukari na 2 na cututtukan zuciya (nephropathy saboda hypercreatininemia da proteinuria).

Bugu da kari, an wajabta magungunan don rage saurin haɓaka cututtukan zuciya (da suka shafi bugun jini), kazalika da rage yawan mace-mace a cikin mutane masu hawan jini da hauhawar jini.

Lozap yana hana damuwa a cikin aikin myocardium, hauhawar jini, yana ƙara ƙarfin zuciya.
Ga yara 'yan kasa da shekaru 18, magani bai dace ba.
Haihuwa da lactation sune contraindications wa amfani da Lozap.
Sakamakon magungunan Lozap yana nufin rage karfin jini.
Nau'i na sakin Lozap shine Allunan.

Abubuwan da ke hana amfani da Lozap sune:

• ciki da lactation,
• rashin hankali ga miyagun ƙwayoyi da abubuwan haɗinsa.

Yaran da ba su cika shekara 18 ba su dace ba.

Hankali kana buƙatar ɗaukar irin wannan magani ga mutanen da ke fama da rashin daidaituwa na ruwa-gishiri, ƙarancin jini, jijiyoyin bugun gini a hanta, hanta ko gazawar koda.

Yaya Lorista yake aiki?

Tsarin sakin magunguna Lorista shine Allunan. Kunshin 1 ya ƙunshi guda 14, 30, 60 ko 90. Babban sinadaran aiki shine losartan. Kwamfutar hannu 1 ta ƙunshi 12.5, 25, 50, 100 da 150 MG.

Ayyukan Lorista an yi niyya don toshe masu karɓar AT 2 a cikin cardiac, na jijiyoyin jini da kuma yankin renal. A sakamakon wannan, lumen arteries, juriyarsu yana raguwa, yawan hauhawar jini ya ragu.

Alamu don amfani kamar haka:

• hauhawar jini
• raguwa a cikin hadarin bugun jini tare da hauhawar jini da nakasa jini na zuciya,
• na kullum zuciya
• rigakafin rikice-rikice da ke haifar da kodan a cikin nau'in ciwon sukari na 2 na sukari tare da ƙarin furotin.

An tsara Lorista don hana rikice rikice da ke faruwa da kodan a cikin nau'in ciwon sukari na 2 tare da ƙarin furotin.
Ayyukan Lorista an yi niyya ne don rage karfin jini.
An tsara maganin don rage haɗarin bugun jini tare da nakasa jini da nakasa jini na zuciya.Tsarin sakin magunguna Lorista shine Allunan.

Contraindications sun haɗa da:

• karancin jini
• bushewa
• damuwa ruwa-gishiri
• rashin daidaituwa na lactose,
• take hakkin tsarin glucose,
• ciki da lactation.
• rashin hankali ga miyagun ƙwayoyi ko abubuwan da ke ciki.

Ga yara 'yan ƙasa da shekaru 18, ba a kuma bada shawarar yin amfani da maganin ba. Ya kamata a yi taka tsantsan ga mutanen da ke fama da cutar koda da kuma ƙwayar jijiya, ƙwayar jijiya a cikin kodan.

Kwatanta Lozap da Lorista

Don sanin wane irin miyagun ƙwayoyi - Lozap ko Lorista - ya fi dacewa da mai haƙuri, wajibi ne don sanin kamanceceniyarsu da yadda magungunan suka bambanta.

Lozap da Lorista suna da kamanni da yawa, kamar yadda Su ne analogues:

• dukkanin magunguna suna cikin rukunin angiotensin 2 antagonists,
• da alamomi iri ɗaya don amfani,
• dauke da sinadaran aiki guda - losartan,
• ana samun zaɓuɓɓuka biyun a cikin kwamfutar hannu.

Amma game da maganin yau da kullun, to 50 MG kowace rana ya isa. Wannan mulkin daidai yake da Lozap da Lorista, kamar yadda shirye-shiryen suna dauke da adadin losartan. Za'a iya siyan magungunan biyu a cikin kantin magunguna kawai ta hanyar likita daga likita.

Lozap da Lorista na iya haifar da matsalar bacci.
Ciwon kai, amai - har ila yau, sakamako ne na kwayoyi.
Lokacin ɗaukar Lorista da Lozap, arrhythmia da tachycardia na iya faruwa.
Ciwon ciki, tashin zuciya, gastritis, zawo sune tasirin magunguna.

Ana ba da haƙuri ga magunguna sosai, amma wasu lokuta alamun da ba a so ba suna iya bayyana. Sakamakon sakamako na Lozap da Lorista suma suna da kama daya:

• matsala barci
• ciwon kai, tsananin farin ciki,
• kullun gajiya
• arrhythmia da tachycardia,
• ciwon ciki, tashin zuciya, gastritis, zawo,
• ambaliya, kumburi daga cikin yatsun mucous a cikin hanci,
• tari, mashako, hanji.

Bugu da kari, dole ne a ɗauka a hankali cewa ana kuma shirye-shiryen haɗuwa - Lorista N da Lozap Plus. Duk magungunan biyu suna dauke da losartan ba kawai azaman sashi mai aiki ba, har ma da wani fili - hydrochlorothiazide. Kasancewar irin wannan kayan taimako a cikin shiri an nuna shi da sunan. Don Lorista, wannan shine N, ND ko H100, kuma don Lozap, kalmar "ƙari".

Lozap Plus da Lorista N sune alamun juna. Duk magungunan sun ƙunshi 50 mg na losartan da 12.5 MG na hydrochlorothiazide.

Shirye-shiryen nau'in haɗuwa an tsara su don tsara matakan kai tsaye 2 waɗanda ke shafar hawan jini. Losartan lowers sautin jijiyoyin bugun gini, kuma hydrochlorothiazide an tsara shi don cire ruwa mai yawa daga jiki.

Fasali na lura da hauhawar jini tare da miyagun ƙwayoyi LozapLorista - magani don rage karfin jini Lozap da umarnin

Menene bambanci?

Bambanci tsakanin Lozap da Lorista ba su da mahimmanci:

• Sashi (Lozap yana da zaɓuɓɓuka 3 kawai, kuma Lorista yana da ƙarin zaɓuka - 5),
• m (Lorista ne daga kamfanin Slovenia ke samarwa, kodayake akwai reshe na Rasha - KRKA-RUS, Lozap kuma kungiyar Slovak Zentiva ce ta samar da shi).

Duk da amfani da ingantaccen kayan aiki guda ɗaya, jerin masanan ma daban. Ana amfani da abubuwan da aka haɗa masu zuwa:

1. Cellactose Gabatar kawai a cikin Lorist Ana samun wannan fili ta dalilin lactose monohydrate da cellulose. Amma na ƙarshen shima yana cikin Lozap.
2. Sitaci. Akwai kawai a cikin Lorist. Haka kuma, akwai jinsuna 2 a cikin maganin iri ɗaya - gelatinized da sitaci masara.
3. Crospovidone da mannitol. An yi shi a cikin Lozap, amma ba a cikin Lorist.

Duk sauran magabata don Lorista da Lozap iri ɗaya ne.

Abinda yafi kyau daga Lozap ko Lorista

Dukansu magunguna suna da tasiri a rukunin su. Amfani da sinadarin losartan yana da fa'idodi masu zuwa:

1. Zaɓi. Magungunan yana nufin ɗaure kawai tare da masu karɓar dole. Saboda wannan, ba ya shafar sauran tsarin jikin mutum. A sakamakon wannan, ana amfani da magungunan biyu amintattu fiye da sauran kwayoyi.
2. Babban aiki lokacin shan magani a cikin nau'i.
3. Babu tasiri a kan hanyoyin rayuwa na fats da carbohydrates, don haka an yarda da magunguna biyu a cikin ciwon sukari.

Losartan an dauki shi ɗayan abubuwa na farko daga ƙungiyar masu toshe, wanda aka yarda dashi don maganin hauhawar jini a cikin 90s. Har yanzu, ana amfani da magunguna dangane da shi don hawan jini.

Dukansu Lorista da Lozap suna da magunguna masu tasiri saboda haɗuwar losartan a cikin taro ɗaya. Amma lokacin zabar magani, ana kuma daukar contraindications.

Lorista ana ɗaukar ɗan hatsari ga mutane fiye da Lozap. Wannan saboda gaskiyar cewa tasirin sakamako zai iya faruwa. Bugu da kari, an haramta irin wannan maganin ga mutanen da ke da rashin jituwa da lactose da kuma rashin lafiyar rashin abinci ga sitaci. Amma a lokaci guda, irin wannan magani yana da rahusa.

Lorista ana ɗaukar ɗan hatsari ga mutane fiye da Lozap.

Reviews daga likitocin zuciya game da Lozap ko Lorista

Danilov SG: "Tsawon shekaru na aikin, Lorista miyagun ƙwayoyi sun tabbatar da kanta. Kayan aiki ne mai arha, amma ingantacce ne. Yana taimaka wajan shawo kan hauhawar jini. Magungunan sun dace don ɗauka, akwai ƙarancin sakamako, kuma da wuya su faru."

Zhikhareva EL: "Lozap magani ne don lura da hauhawar jini. Yana da tasiri mai laushi, don haka matsin lamba baya raguwa sosai.

Aikin magunguna

Magungunan rigakafi Musamman mai karɓar angiotensin II mai karɓar antagonist (ƙarancin AT1). Ba ya hana kininase na II, wani enzyme wanda ke daukar nauyin juyowar angiotensin I zuwa angiotensin II. Yana rage OPSS, maida hankali na jini adrenaline da aldosterone, hawan jini, matsin lamba a cikin jijiyoyin bugun zuciya, yana rage nauyi bayan aiki, yana da tasirin diuretic. Yana sa baki tare da haɓakar hauhawar jini na zuciya, yana ƙaruwa da haƙuri a cikin marasa lafiya tare da rauni na zuciya. Losartan baya hana ACE kininase II kuma, saboda haka, baya hana lalata bradykinin, saboda haka sakamako masu illa da aka haɗa kai tsaye da bradykinin (alal misali, angioedema) suna da wuya.

A cikin marasa lafiya tare da hauhawar jini ba tare da conellitus na ciwon sukari mai narkewa tare da proteinuria (fiye da 2 g / rana), yin amfani da miyagun ƙwayoyi yana rage proteinuria, haɓakar albumin da immunoglobulins G.

Yana daidaita matakin urea a cikin jini na jini. Ba ya shafar tasirin ciyayi kuma ba shi da wani tasiri na dogon lokaci kan tarowar norepinephrine a cikin jini. Losartan a kashi har zuwa 150 MG kowace rana ba ya shafar matakin triglycerides, jimlar cholesterol da HDL cholesterol a cikin jijiyoyin jini a cikin marasa lafiya tare da tashin hankali na jijiya. A daidai wannan matakin, losartan baya shafar glucose na jini.

Bayan gudanar da maganin baka guda ɗaya, tasirin mai narkewa (systolic da diastolic pressure saukar jini) ya kai matsakaici bayan sa'o'i 6, sannan sannu a hankali ya rage a cikin sa'o'i 24.

Matsakaicin sakamako mai lalacewa yana tasowa makonni 3-6 bayan fara maganin.

Pharmacokinetics

Lokacin da aka shiga cikin damuwa, losartan yana da kyau sosai, kuma yana halakar da metabolism yayin "hanyar farko" ta hanta ta hanyar carbonxylation tare da halartar cytochrome CYP2C9 isoenzyme tare da samuwar metabolite mai aiki. Tsarin bioavailability na losartan shine kusan 33%. Cmax na losartan da aiki metabolite ana samun su cikin jijiyoyin jini bayan kamar awa 1 da sa'o'i 3-4 bayan fitowar, bi da bi. Cin abinci baya tasiri bioavailability na losartan.

Fiye da 99% na losartan da aiki na metabolite suna ɗaure su ga furotin na plasma, galibi tare da albumin. Vd losartan - 34 l. Losartan a zahiri ba ya ratsa cikin BBB.

Aƙalla 14% na losartan da aka bayar a cikin tayin ko kuma ta baki yana canzawa zuwa aiki mai aiki.

Shafin ruwan plasa na losartan shine 600 ml / min, kuma metabolite mai aiki shine 50 ml / min. Batun danyen danne na losartan da kuma metabolite dinsa mai aiki shine 74 ml / min da 26 ml / min, bi da bi. Lokacin da aka shiga ciki, kusan kashi 4% na kashin da aka dauka ana raba shi ne da kodan ba shi canzawa kuma kusan 6% na kodan ya kasance a cikin hanyar metabolite mai aiki. Losartan da metabolite mai aiki suna nunawa ta hanyar magunguna masu layi lokacin da aka sha ta baki a allurai har zuwa 200 MG.

Bayan sarrafawa na baka, ƙwayar plasma na losartan da ƙwayar metabolite mai aiki suna raguwa tare da T1 / 2 na losartan na ƙarshe kimanin 2 hours, da kuma metabolite mai aiki kimanin awa 6-9. Lokacin shan maganin a kashi na 100 mg /, ba losartan ko kuma aiki metabolite mai mahimmanci sun tara a cikin jini jini. Losartan da metabolites din an kebe su ta hanjin ciki da kodan. A cikin masu sa kai masu lafiya, bayan fitowar 14C tare da isotope na alamomin losartan, kusan 35% na alamar rediyo ana samun su a cikin fitsari da kuma 58% a cikin feces.

Pharmacokinetics a cikin lokuta na musamman na asibiti

A cikin marasa lafiya masu laushi zuwa matsakaici na giya cirkohosis, yawan losartan ya kasance sau 5, kuma mai aiki na metabolite ya kasance sau 1.7 sama da na masu sa kai na maza masu lafiya.

Tare da keɓancewar creatinine mafi girma daga 10 ml / min, tattarawar losartan a cikin ƙwayar jini bai bambanta da wannan tare da aikin aikin koda. A cikin marasa lafiya waɗanda ke buƙatar hemodialysis, AUC ya kusan sau 2 fiye da marasa lafiya da ke da aikin na al'ada.

Ba za a iya cire losartan ko metabolite mai aiki daga jiki ta hanyar motsa jini ba.

Haɗarin losartan da ƙwayar metabolite mai aiki a cikin jini na tsofaffi maza tare da hauhawar jijiyoyi ba su bambanta da mahimmancin waɗannan sigogi a cikin samari da ke fama da hauhawar jini.

Yawan plasma na losartan a cikin mata da ke fama da hauhawar jijiyoyin jini sun ninka 2 sau da yawa kamar yadda yake a cikin maza tare da hauhawar jini. Ba a bambanta abubuwan da ke faruwa a cikin maza da mata ba. Wannan bambance-bambancen magani ba shi da mahimmanci a asibiti.

Alamu don amfani da miyagun ƙwayoyi LOZAP®

• hauhawar jini
• rashin lafiyar zuciya na kullum (a matsayin wani ɓangare na maganin haɗin gwiwa, tare da rashin haƙuri ko rashin aiki na rashin lafiya tare da masu hana ACE),
• rage hadarin kamuwa da cututtukan zuciya (gami da bugun jini) da mace-mace a cikin marasa lafiya da hauhawar jini da jijiyoyin jini na hagu,
• nephropathy na ciwon sukari tare da hypercreatininemia da proteinuria (rabo daga albumin fitsari da creatinine fiye da 300 mg / g) a cikin marasa lafiya da nau'in ciwon sukari na 2 da kuma hauhawar jini na jijiya (rage ci gaba na cutar ciwon sukari zuwa ƙarewar lalacewa ta ƙarancin lokaci).

Sashi da gudanarwa

Ana ɗaukar magani a baka, ba tare da la'akari da abincin ba. Maimaitawa da yawa - sau 1 a rana.

Tare da hauhawar jini, matsakaicin yawan yau da kullun shine 50 MG. A wasu halaye, don cimma sakamako mafi girma na warkewa, ana iya ƙara kashi ɗaya na yau da kullun zuwa 100 MG a cikin kashi 2 ko 1.

Maganin farko ga marasa lafiya da raunin zuciya shine 12.5 MG sau ɗaya a rana. A matsayinka na mai mulki, ana karuwa da kashi tare da tazara ta mako (i.e. 12.5 mg a kowace rana, 25 MG a rana, 50 MG a kowace rana) zuwa matsakaiciyar kiyayewa na 50 MG 1 a kowace rana, gwargwadon haƙuri da miyagun ƙwayoyi.

Lokacin da yake ba da magani ga marasa lafiya da ke karɓar diuretics a allurai masu yawa, kashi na farko na Lozap® ya kamata a rage zuwa 25 MG sau ɗaya a rana.

Ga tsofaffi marasa lafiya, babu buƙatar daidaita sashi.

Lokacin da ake tsara magunguna don rage haɗarin cututtukan cututtukan zuciya (ciki har da bugun jini) da mace-mace a cikin marasa lafiya da hauhawar jijiya da hauhawar jini ventricular hagu, kashi na farko shine 50 MG kowace rana. A nan gaba, za'a iya ƙara ƙaramin hydrochlorothiazide kuma / ko kuma ana iya ƙara kashi na shiri na Lozap® zuwa 100 MG kowace rana a cikin allurai 1-2.

Ga marasa lafiya da ke dauke da nau'in ciwon sukari guda biyu na sukari guda biyu tare da proteinuria, kashi na farko na miyagun ƙwayoyi shine 50 MG sau ɗaya a rana, a nan gaba, ana ƙaruwa kashi zuwa 100 MG kowace rana (yin la'akari da matakin rage hauhawar jini) a cikin 1-2 na allurai.

Marasa lafiya da ke da tarihin cutar hanta, rashin ruwa, lokacin aikin hemodialysis, haka kuma marasa lafiya da suka haura shekaru 75, ana ba da shawarar ƙananan magunguna na farko - 25 mg (1/2 kwamfutar hannu na 50 MG) sau ɗaya a rana.

Side sakamako

Lokacin amfani da losartan don kulawa da mahimmancin hauhawar jini a cikin gwaji masu sarrafawa, a tsakanin duk tasirin sakamako, kawai yanayin tashin hankali ya bambanta daga placebo fiye da 1% (4.1% a kan 2.4%).

Isticaukar halayen orthostatic sakamako na wakilai na antihypertensive, tare da yin amfani da losartan an lura da ƙasa da 1% na marasa lafiya.

Dayyade yawan tasirin sakamako: sau da yawa (≥ 1/10), sau da yawa (> 1/100, ≤ 1/10), wani lokacin (≥ 1/1000, ≤ 1/100), da wuya (≥ 1/10 000, ≤ 1 / 1000), da wuya (≤ 1/10 000, hade da saƙonnin guda ɗaya).

Sakamakon sakamako wanda ke faruwa tare da adadin fiye da 1%:

Sakamakon sakamako na losartan yawanci a kan lokaci ne kuma baya buƙatar dakatar da magani.

Sakamakon sakamako wanda ke faruwa tare da ƙarancin 1%

Daga tsarin zuciya: orthostatic hypotension (dogara-kashi), hanci, kumburi, bradycardia, arrhythmias, angina pectoris, vasculitis, infarction na myocardial.

Daga tsarin narkewa: anorexia, bushe mucosa na baki, ciwon hakori, amai, flatulence, gastritis, maƙarƙashiya, hepatitis, aikin hanta mai rauni, da wuya - ƙaruwa mai sauƙi a cikin ayyukan AST da ALT, hyperbilirubinemia.

Abubuwan da ke tattare da cututtukan cututtukan fata: bushe fata, erythema, ecchymosis, daukar hoto, karuwar gumi, alopecia.

Allergic halayen: urticaria, fatar fata, itching, angioedema (ciki har da kumburi da harshe, haifar da toshewar hanyoyin da / ko kumburi da fuska, lebe, pharynx).

A wani ɓangare na tsarin hematopoietic: wani lokacin anaemia (wani ɗan ƙarami a cikin haɓakar hemoglobin da hematocrit, a matsakaici ta 0.11 g% da 0.09 girma%, bi da bi, da wuya - na mahimmancin asibiti), thrombocytopenia, eosinophilia, Shenlein-Genokha purpura.

Daga tsarin musculoskeletal: arthralgia, amosanin gabbai, jin zafi a kafada, gwiwa, fibromyalgia.

Daga gefen tsarin juyayi na tsakiya da tsarin jijiyoyin jiki na juyayi: damuwa, damuwa na bacci, matsananciyar damuwa, raunin ƙwaƙwalwar ajiya, jijiyoyin mahaifa, paresthesia, hypesthesia, rawar jiki, ataxia, ɓacin rai, fainting, migraine.

Daga gabobin azanci: tinnitus, tayar da hankali, raunin gani, conjunctivitis.

Daga tsarin urinary: urination na hanzari, cututtukan urinary fili, raunin aiki na koda, wani lokacin - ƙara yawan urea da saura nitrogen ko creatinine a cikin jini.

Daga tsarin haihuwa: rage libido, rashin ƙarfi.

Daga gefen metabolism: sau da yawa - hyperkalemia (matakin potassium a cikin jini na jini ya fi 5.5 mmol / l), gout.

Contraindications zuwa ga yin amfani da miyagun ƙwayoyi LOZAP®

• ciki
• lactation
• shekaru har zuwa shekaru 18 (ba a kafa ingantaccen aiki da aminci ba),
• rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi.

Tare da taka tsantsan, ya kamata a yi amfani da miyagun ƙwayoyi don maganin jijiya, raguwa a cikin bcc, daidaitawar ruwa-electrolyte mai lalacewa, ƙayyadadden hular koda na jijiya ko ƙyallen jijiya na koda ɗaya, da ƙarancin koda / na hepatic.

Amfani da LOZAP® a lokacin daukar ciki da lactation

Babu bayanai game da amfani da miyagun ƙwayoyi Lozap® yayin daukar ciki. Koyaya, sananne ne cewa magungunan da ke tasiri RAAS kai tsaye, lokacin amfani dashi a cikin sakan na biyu da na uku na ciki, na iya haifar da lahani na haɓaka ko ma mutuwar tayi. Sabili da haka, idan ciki ya faru, ya kamata a dakatar da miyagun ƙwayoyi nan da nan.

Idan ya zama dole ayi amfani da Lozap yayin shayarwa, to yakamata a yanke shawara ko dai a daina shayar da jariri, ko kuma a daina magani da magani.

Umarni na musamman

Wajibi ne don gyara bushewar bushewa kafin rubuta magunguna Lozap® ko fara magani tare da amfani da miyagun ƙwayoyi a cikin ƙananan kashi.

Magunguna waɗanda ke shafar RAAS na iya haɓaka urea da jini a cikin marasa lafiya da ke fama da cutar sankarar jijiya ko ƙwallon ƙafa ɗaya koda.

A cikin marasa lafiya da ke fama da cutar hanta, haɗuwa da losartan a cikin jini na jini yana ƙaruwa sosai, sabili da haka, idan akwai tarihin cutar hanta, ya kamata a tsara shi a ƙananan allurai.

A lokacin kulawa, ya kamata a sa ido kan abubuwan da ke cikin potassium a cikin jini a kai a kai, musamman ma a cikin tsofaffi marassa lafiya, tare da nakasa aikin na koda.

Hulɗa da ƙwayoyi

Ana iya tsara magungunan tare da wasu jami'ai na antihypertensive. An lura da ƙarfin ƙarfafawar tasirin beta-blockers da tausayawa. Tare da yin amfani da losartan tare da diuretics, ana lura da sakamako mai ƙari.

Babu hulɗa na pharmacokinetic na losartan tare da hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital, ketoconazole da erythromycin da aka lura.

An bayar da rahoton Rifampicin da fluconazole don rage yawan haɗarin metabolite na losartan a cikin jini na jini. Har yanzu ba a san mahimmancin asibitin wannan hulɗa ba.

Kamar yadda yake tare da sauran jamiái waɗanda ke hana angiotensin II ko tasirin sa, haɗuwa da amfani da losartan tare da daskararren ƙwayoyin potassium (alal misali, spironolactone, triamteren, amiloride), shirye-shiryen potassium da gishiri wanda ke dauke da potassium yana kara haɗarin cutar hyperkalemia.

NSAIDs, ciki har da masu hana COX-2 masu hanawa, na iya rage tasirin diuretics da sauran magungunan antihypertensive.

Ta haɗu da amfani da angiotensin II da antagonists mai karɓa na lithium, haɓakar ƙwaƙwalwar ƙwayar plasma yana yiwuwa. Ganin wannan, ya zama dole a auna fa'ida da kuma hatsarin hadin-gwiwar gudanar da ayyukan losartan tare da shirye-shiryen gishiri. Idan amfani da haɗin gwiwa ya zama dole, ya kamata a sa ido akan tattara lithium a cikin jini jini akai-akai.