Insulin Insuman Bazal GT

Dakatarwa ga subcutaneous management na 100 IU / ml

1 ml na dakatarwa ya ƙunshi

abu mai aiki - mutum insulin 100 IU (3,571 mg),

magabata: 85% glycerol, protamine sulfate, metacresol, phenol, zinc chloride, sodium hydrogen phosphate dihydrate, soda sodium hydroxide, acid hydrochloric acid, ruwa don allura.

Da sauri yada dakatarwar fari ko kusan fari. Mai nuna fifikon gaskiya ne ko kuma kusan aminta.

Kayan magunguna

Pharmacokinetics

Insuman® Basal GT (isofan-insulin dakatarwa) shine insulin tare da haɓaka mai hankali da tsawaita aiki. Bayan subcutaneous management, sakamako yana faruwa a cikin minti 60, ana lura da matakin mafi girman aiki 3-4 awanni bayan allurar, tasirin yana tsawan sa'o'i 11-20.

Rabin rayuwar insulin daga magani shine kimanin minti 4-6. Yayi tsawo cikin gazawa na rashin aiki. Ya kamata a sani cewa pharmacokinetics na insulin baya nuna sakamakon tasirinsa.

Pharmacodynamics

Insuman® Basal HT ya ƙunshi m insulin a cikin tsari ga insulin ɗan adam, wanda aka samu ta hanyar fasahar DNA ta sake amfani da ita Escherichia coli.

Insuman® Bazal GT

- yana rage glucose jini kuma yana ba da gudummawa ga tasirin anabolic, haka kuma yana rage tasirin catabolic

- haɓaka jigilar glucose a cikin sel, kazalika da ƙirƙirar glycogen a cikin tsokoki da hanta, yana inganta amfani da pyruvate. Yana hana glycogenolysis da glyconeogenesis

- yana haɓaka lipogenesis a cikin hanta da ƙwaƙwalwar adipose da kuma yana hana lipolysis

- yana haɓaka yawan amfani da amino acid ta sel kuma yana amfani da haɓakar furotin

- asesara yawan ci a cikin sel ta sel.

Sashi da gudanarwa

Matakan glucose na jini da ake so, shirye-shiryen insulin da za ayi amfani da su kuma an tsara jigilar kashi (kashi, rarraba lokaci) daban bisa tsarin abinci, matakin motsa jiki da salon rayuwar mai haƙuri.

Alluran yau da kullun da lokacin gudanarwa

Babu ƙa'idoji marasa ƙarancin gaske game da allurar insulin. Matsakaicin insulin yau da kullun shine 0.5-1.0 IU a kowace kilogiram na nauyin jikin mai haƙuri. Babban abinda ake buƙata na insulin shine kashi 40-60% na yawan bukatun yau da kullun. Insuman® Bazal GT ana sarrafa shi a ƙasa sau 45-60 kafin cin abinci.

Gyara matakan sakandare

Inganta sarrafawa na rayuwa na iya haifar da ƙwarewar insulin, yana haifar da ƙananan buƙatun insulin. Ana iya buƙatar daidaita yanayin koda idan akwai canje-canje a cikin nauyin mai haƙuri, salon rayuwa, da sauran halaye waɗanda zasu iya ba da gudummawa ga karuwar haɓakar hauhawar jini ko hyperglycemia (duba “Umarni na Musamman”).

Groupsungiyoyin haƙuri na musamman

Ana iya rage buƙatar insulin idan akwai hanta mai rauni ko aikin koda kuma a cikin tsufa (duba "Umarni na Musamman").

An shiga da jijiyoyin wuya

Insuman® Ana gudanar da gasa da mahimmanci a ƙarƙashin ƙasa.

Rashin insulin kuma, saboda haka, tasirin rage sukari na allura na iya bambanta, gwargwadon wurin allura (alal misali, bangon ciki idan aka kwatanta da yankin femasin). Dole ne a canza wurin allurar kowane lokaci tsakanin yanki guda.

Pharmacodynamics

Insuman ® Basal GT ya ƙunshi m insulin a cikin tsari ga insulin ɗan adam kuma ya samo ta ta injiniyan kwayoyin ta amfani da damuwa Escherichia coli K12 135 pINT90d.

Hanyar aikin insulin:

Yana rage taro glucose a cikin jini, yana inganta tasirin anabolic da rage tasirin catabolic,

Yana ƙara jigilar glucose a cikin sel da samuwar glycogen a cikin tsokoki da hanta kuma yana inganta amfani da pyruvate, yana hana glycogenolysis da glyconeogenesis,

Liara lipogenesis a cikin hanta da tsopose nama da kuma yana hana lipolysis,

Yana inganta kwararar amino acid a cikin sel da kuma tsarin furotin,

Potassiumara yawan shan ƙwayar potassium a cikin sel.

Insuman ® Bazal GT suna insulin aiki akai-akai tare da fara aiki a hankali. Bayan sc gwamnati, tasirin hypoglycemic yana faruwa a cikin awa 1 kuma ya kai matsakaici a cikin sa'o'i 3-4. Tasirin ya ci gaba na tsawon awanni 11 zuwa 20.

Contraindications

tashin hankali ga insulin ko zuwa wasu daga cikin abubuwan taimako na maganin, sai dai idan insulin yana da mahimmanci,

Tare da kulawa: gazawar koda metabolism metabolism), tsauraran matsanancin jijiyoyin jini da jijiyoyin jini (a cikin waɗannan marasa lafiya, aukuwa na hypoglycemic na iya samun ƙimar asibiti na musamman, i.e. K. akwai haɗarin haɗarin cututtukan zuciya ko rikicewar ƙwayar cuta na mahaifa), marasa lafiya waɗanda ke fama da farfadowa na fata, musamman waɗanda ba su karɓi magani tare da photocoagulation (laser therapy), saboda tare da hypoglycemia akwai haɗarin tashin hankali mara jinkiri - cikakken makanta, marasa lafiya waɗanda ke fama da cututtukan intercurrent (saboda cututtukan intercurrent sau da yawa suna buƙatar buƙatar insulin).

Idan mai haƙuri yana da ɗayan waɗannan cututtukan ko yanayin, ya kamata koyaushe ku nemi likitanku kafin amfani da miyagun ƙwayoyi.

Haihuwa da lactation

Jiyya tare da Insuman ® Basal GT yayin daukar ciki ya kamata a ci gaba. Insulin baya ƙetare shingen ƙarfe. Ingancin kiyayewa na sarrafa kwayoyin cuta a duk lokacin daukar ciki ya zama tilas ga matan da ke da ciwon sukari kafin daukar ciki, ko kuma ga matan da suka kamu da ciwon suga.

Bukatar insulin a lokacin daukar ciki na iya raguwa yayin farkon farkon ciki kuma yawanci yana ƙaruwa yayin watanni na biyu da na uku na ciki. Nan da nan bayan haihuwa, buƙatar insulin ya ragu da sauri (ƙara haɗarin hauhawar jini). Yayin cikin ciki kuma musamman bayan haihuwa, ana buƙatar saka idanu sosai akan yawan glucose a cikin jini.

Idan kana da ciki ko kuma kana shirin daukar ciki, to ka sanar da likitanka.

Yayin shayarwa, babu hani akan maganin insulin, kodayake, ana buƙatar sashin insulin da kuma sauyin abinci.

Side effects

Hypoglycemia. Sakamakon sakamako na yau da kullun na insulin farjin zai iya haɓaka idan kashi na insulin da aka gudanar ya wuce buƙatar shi (duba "Umarnin na Musamman"). Abubuwa masu maimaitawa na mawuyacin hali na rashin ƙarfi na jini na iya haifar da ci gaban bayyanar cututtuka, ciki har da coma, cramps (duba "overdose"). Tsawo ko tsauraran matakai na hypoglycemia na iya zama barazanar rayuwa.

A cikin marasa lafiya da yawa, alamu da bayyanar cututtuka na neuroglycopenia na iya zuwa gabanin alamun bayyanarwa (a cikin martani ga haɓakar haɓakawar jini) kunna tsarin juyayi mai juyayi. Yawancin lokaci, tare da mafi yawan magana ko raguwa da sauri a cikin tattarawar glucose a cikin jini, sabon abu na reflex kunna tsarin juyayi mai juyayi da alamominsa sun fi faɗi.

Tare da raguwa mai yawa a cikin taro na glucose a cikin jini, haɓakar hypokalemia (rikitarwa daga CCC) ko haɓakar edema zai yiwu.

Abubuwanda ke faruwa suna faruwa ne a cikin gwaji na asibiti wanda aka tsara ta tsarin azuzuwan sassan jiki da kuma rage yawan abin da ya faru: sosai (≥1 / 10), akai-akai (≥1 / 100 da Sabon, wanda endocrinologists ke ba da shawara ga Ci gaba da Ciwon sukari! Abin kawai ya zama dole a kowace rana.

Wannan magani samfurin Sanofi ne, wanda ke samar da sanannun Lantus, Apidra da Tujeo. Rashin aikin insuman a cikin kasuwar insulin kusan 15%. A cewar masu ciwon sukari, mafita ya dace don amfani, ana nuna shi ta hanyar inganci koyaushe. Akwai nau'ikan insulin guda biyu a cikin layin: matsakaici Insuman Bazal da gajeren Insuman Rapid.

Ta yaya miyagun ƙwayoyi ke aiki?

Insuman shine asalin injin ɗan adam. A kan sikelin masana'antu, ana samar da hormone ta amfani da kwayoyin cuta. Idan aka kwatanta da insulins da aka yi amfani da su a baya, injin-ɗabi'a suna da sakamako mafi tsayayye da tsabtatawa mai inganci.

A da, makasudin insulin shine yaƙar mutuwa. Tare da shigowar insulin ɗan adam, ƙalubalen ya canza. Yanzu muna magana ne game da rage haɗarin rikice-rikice da cikakken rayuwar marasa lafiya. Tabbas, don cimma wannan akan analogs na insulin yana da sauki, amma akan biyan bashin Insuman don maganin cutar sankara yana yiwuwa. Don yin wannan, kuna buƙatar karanta umarnin don maganin, bayanin martabarsa na aiki, koya da daidaita shi da kyau.

Ciwon sukari da hauhawar jini zai zama abin da ya wuce

Cutar sankarau shine sanadin kusan kashi tamanin cikin ɗari na duka raunin da aka yanke. Mutane 7 daga 10 ne ke mutuwa sakamakon kamuwa da jijiyoyin zuciya da kwakwalwa. A kusan dukkanin lokuta, dalilin wannan mummunan ƙarshen shine guda - sukari na jini.

Sugar zai iya kuma ya kamata a rushe, in ba haka ba komai. Amma wannan ba ya warkar da cutar da kanta, amma kawai tana taimakawa wajen yaƙar bincike, kuma ba dalilin cutar ba.

Kadai magani wanda aka bayar da shawarar a hukumance ga masu ciwon sukari kuma masu amfani da endocrinologists suna amfani da su a cikin aikin shine Ji Dao Ciwon Ciwon Ciwon.

Tasirin maganin, wanda aka lasafta bisa ga daidaitaccen hanyar (adadin marasa lafiyar da suka murmure zuwa jimlar yawan marasa lafiya a cikin rukuni na mutanen 100 waɗanda suka sami kulawa) sun kasance:

• Normalization na sukari - 95%
• Cirewa kan jijiyoyin mara wuya - 70%
• Cire zuciyar mai karfin zuciya - 90%
• Rabu da cutar hawan jini - 92%
• Thearfafa rana, inganta bacci da dare - 97%

Masu samar da Ji Dao ba kungiyar kasuwanci ba ce kuma jihar ce ke daukar nauyinta. Sabili da haka, yanzu kowane mazaunin yana da damar samun magungunan a ragi na 50%.

Ba za a iya daidaitawa kwalajin kwayar halittar hormone cikin lafiya ba. Babban saki insulin yana faruwa ne yayin amsawar glucose da ke shiga jijiyar jini daga abinci. Koyaya, idan mutum yana jin yunwa ko yana bacci, har yanzu akwai insulin a cikin jini, kodayake cikin adadi kaɗan - a matakin da ake kira basal. Lokacin da samar da hormone ya tsaya tare da ciwon sukari, an fara canza magani. Wannan yawanci ana buƙatar nau'ikan insulin guda 2 ne. Matsayin basal yana kwaikwayon Insuman Bazal, yana shiga cikin jini a hankali, na dogon lokaci kuma a cikin ƙananan rabo. Sugar bayan cin abinci an tsara shi don rage Insuman Rapid, wanda ya isa tasoshin da sauri.

Kwatanta halayen Insumans:

Dokokin aikace-aikace

Bukatar insulin na mutum ɗaya ne ga kowane mai ciwon sukari. A matsayinka na mai mulkin, marasa lafiya da ke da nau'in cuta na 2 da kiba suna buƙatar ƙarin hormone. Dangane da umarnin don amfani, a kan matsakaita kowace rana, marasa lafiya suna yin allurar har zuwa 1 na miyagun ƙwayoyi a kowace kilo kilogram na nauyi. Wannan adadi ya hada da Insuman Bazal da Rapid. Short insulin yakai kashi 40-60% na yawan bukata.

Insuman Bazal

Tun da Insuman Bazal GT ke aiki ƙasa da rana, dole ne ku shigar da shi sau biyu: da safe bayan auna sukari da kafin lokacin kwanciya. Allurai na kowace gwamnati ana kirga daban. A saboda wannan, akwai dabaru na musamman waɗanda ke yin la’akari da hankalin mutum game da sinadarin hormone da glycemia. Matsakaicin da ya dace ya kamata ya kiyaye matakin sukari a lokacin da mai cutar da ciwon sukari ke jin yunwa.

Insuman Bazal dakatarwa ne, yayin ajiya yana exfoliates: bayyananne bayani ya kasance a saman, fararen fata yana ƙasa. Kafin kowane allura, da miyagun ƙwayoyi a cikin sirinji na alkalami buƙatar Mix da kyau . Duk lokacin da aka sanya suturar ta zamanto, za a dauki karin matakan da ake so daidai. Insuman Bazal ya fi sauƙi a shirya don gudanarwa fiye da sauran ƙananan matsakaici. Don sauƙaƙe haɗuwa, an shirya katako tare da kwallaye uku, waɗanda ke ba da damar samun cikakkiyar daidaituwa na dakatarwa a cikin 6 kawai na alkairin sirinji.

Shirya don amfani da Insuman Bazal yana da fararen launi iri ɗaya. Alamar lalacewar da miyagun ƙwayoyi shine flakes, lu'ulu'u, da goge launi daban-daban a cikin kundin bayan hadawa.

Insuman Rapid

Short Insuman Rapid GT allurar kafin abinci, yawanci sau uku a rana. Yana fara aiki bayan minti 30, don haka dole ne a yi allurar gaba. Don haɓaka diyya na ciwon sukari, yana da kyawawa don cimma daidaituwa na karɓar ɓangarorin insulin da glucose a cikin jini.

Don yin wannan, kuna buƙatar:

1. Fara abincinku da jinkirin carbohydrates da furotin. Ana barin carbohydrates mai sauri a ƙarshen cin abinci.
2. Ku ci kaɗan tsakanin manyan abincin. Don abun ciye-ciye, 12-20 g na carbohydrates sun isa.

Matsayin Insuman Rapid an ƙaddara shi da adadin carbohydrates a cikin abinci da kayan ciye-ciye mai zuwa. Adadin da aka ƙididdige daidai yana ba ku damar cirewa daga tasoshin duk sukari da ya zo da abinci.

Insulin mai sauri koyaushe yana a bayyane, ba kwa buƙatar haɗa shi, ana iya amfani da alkairin sirinji ba tare da shiri ba.

Maganin allura

Wanda masana'antun ke samar da Insuman a cikin nau'ikan 5 ml vials, katako 3 ml da alƙaliman sirinji. A cikin kantin magunguna na Rasha, ya fi sauƙi don siyan magani wanda aka sanya shi a cikin allon alkairin SoloStar. Sun ƙunshi 3 ml na insulin kuma baza'a iya amfani dashi ba bayan magungunan sun ƙare.

Yadda za a shiga Insuman:

1. Don rage zafin allurar kuma rage haɗarin lipodystrophy, ƙwayar a cikin ƙwayar sirinji ya kamata ya kasance da zazzabi a ɗakin.
2. Kafin amfani, ana bincika katun a hankali don alamun lalacewa. Don kada mara haƙuri ya rikitar da nau'in insulin, ana yiwa alamar alƙalami tare da zoben launuka masu dacewa da launi na rubutun a kan kunshin. Insuman Bazal GT - kore, Rapid GT - rawaya.
3. An mirgine Insuman Bazal tsakanin tafin hannu sau da yawa don haɗawa.
4. An ɗauki sabon allura don kowane allura. Reuse ya lalata ɓacin nama. Duk wata allura ta duniya kamar ta alkairin SoloStar sirinji: MicroFine, Insupen, NovoFine da sauransu. An zaɓi tsayin allura gwargwadon kaurin kitse mai ƙyalƙyali.
5. Alƙalin sirinji yana ba ku damar farashi daga raka'a 1 zuwa 80. Insumana, daidaituwar dosing - 1 naúrar. A cikin yara da marasa lafiya a kan rage cin abinci na carbohydrate, buƙatar homonin zai iya zama kaɗan, suna buƙatar mafi girman daidaito a tsarin ƙirar. SoloStar bai dace da irin waɗannan lamuran ba.
6. An fi dacewa da Insuman Rapid a ciki, Insuman Bazal - a cinya ko gindi.
7. Bayan gabatarwar mafita, allurar an bar ta a cikin jikin na wani sakan 10 don kada kwayar ta fara zuba.
8. Bayan kowane amfani, an cire allura. Insulin yana tsoron hasken rana, saboda haka kuna buƙatar rufe katako nan da nan tare da hula.

Side sakamako

Idan ana gudanar da maganin fiye da abin da ake buƙata, yana faruwa. Yana da shi ne mafi yawan sakamako gefen sakamako na insulin far, ba tare da la'akari da irin insulin amfani. Hypoglycemia na iya ƙaruwa da sauri, saboda haka ko da ƙarancin saukad da sukari da ke ƙasa da al'ada ya kamata a kawar da shi nan da nan.

Sakamakon sakamako na Insuman shima ya hada da:

Likita na Kimiyyar Kimiyya, Shugaban Cibiyar Nazarin Diabetology - Tatyana Yakovleva

Na yi shekaru da yawa ina nazarin ciwon sukari. Yana da ban tsoro yayin da mutane da yawa suka mutu, har ma da yawa suna zama masu rauni saboda cutar sankara.

Na yi hanzarin ba da labari mai daɗi - Cibiyar Binciken Endocrinological na Kwalejin Kimiyya ta Rasha ta sami nasarar inganta maganin da ke warkar da ciwon sukari gaba daya. A yanzu, ingancin wannan magani yana gab da kashi 98%.

Wani albishir: Ma'aikatar Lafiya ta tabbatar da ɗaukar wani shiri na musamman wanda zai biya diyyar magunguna mai yawa. A Rasha, masu ciwon sukari har zuwa Afrilu 23 (m) samun shi - Don kawai 147 rubles!

1. Cutar koda zuwa abubuwanda aka gyara. Yawancin lokaci ana bayyana shi a cikin itching, redness, fitsari a cikin yankin gudanarwa. Sau da yawa ƙasa da ƙasa (bisa ga umarni, ƙasa da 1%) halayen anaphylactic faruwa: bronchospasm, edema, saukarwa da ƙarfi, girgiza.
2. Sodium riƙewa. Yawancin lokaci ana lura dashi a farkon jiyya, lokacin da sukari daga manyan lambobi ya sauka zuwa al'ada. Hypernatremia yana tare da edema, hawan jini, ƙishirwa, haushi.
3. Samuwar ƙwayoyin rigakafi don insulin a cikin jiki shine halayyar aikin insulin na tsawon lokaci. A wannan yanayin, ana buƙatar haɓakar ƙwayar insuman. Idan kashi da ake so ya yi girma da yawa, za a tura mai haƙuri zuwa wani nau'in insulin ko an tsara magungunan immunosuppressive.
4. Kyakkyawan ci gaba a cikin biyan diyya na iya haifar da rauni na gani na ɗan lokaci.

Mafi sau da yawa, sannu a hankali jikin mutum ya saba da insulin, kuma rashin lafiyan yakan tsaya. Idan sakamako na gefe yana da barazanar rayuwa (faɗakarwar anaphylactic) ko bai ɓace ba bayan makonni 2, yana da kyau a maye gurbin maganin tare da analog. Insuman Bazal GT - ko, Saurin GT -, ko Tsakanin Humulin. Wadannan kwayoyi sun bambanta kawai a cikin magabata. Bayanin aikin abu ɗaya ne a gare su. Lokacin da rashin lafiyar insulin na mutum, sukan canza zuwa insulin analogues.

Farashin Insuman yayi daidai da darajar harajin sa. Magungunan a cikin sirinji ya ƙima kimanin 1100 rubles. da 15 ml (raka'a 1500, almarar 5 sirinji). Isofan-insulin yana cikin jerin mahimman magunguna, don haka masu ciwon sukari suna da damar samunsa kyauta .

Umarni na musamman

Hypoglycemia shine mafi kyawun sakamako na rashin lafiyar insulin, don haka wani sashi na daban an kebe shi a cikin umarnin amfani da insuman. Rashin haɗari na sukari mai haɗari yana da girma musamman a farkon amfani da insulin, lokacin da mara lafiya yana koyo don ƙididdige yawan maganin. A wannan lokacin, ana bada shawarar kulawa da glucose mai zurfi: ana amfani da mitar ba kawai da safe da kuma abinci ba, har ma a tsaka-tsaki.

Hypoglycemia an tsayar da shi a farkon alamun ko tare da ƙarancin sukari, koda kuwa baya tasiri da ƙoshin lafiya. Alamar hatsari: juyayi, yunwar, rawar jiki, yawan magana ko tsoratar da harshe, lebe, bugun jini, ciwon kai. Theara yawan hauhawar jini na iya kasancewa ana ɗaukar shakku, rikicewar iko da sarrafa kai da motsi. Bayan asarar farkawa, yanayin da sauri yayi rauni, yana farawa.

A duk lokacin da yanayin cututtukan jini ke sake faruwa, mafi muni da mai ciwon sukari yana jin alamun sa, kuma mafi haɗari na raguwar sukari na gaba. Yawancin hypoglycemia yana buƙatar daidaita sashi na Insuman. Taimako na Farko ga Kasuwancin Kaya - 20 g glucose . Wannan kashi na iya wucewa a cikin matsanancin yanayi, tunda wuce haddi na carbohydrates zai haifar da sauri zuwa wannan jihar - hyperglycemia.

Wani rikitarwa na cututtukan hawan jini shine. Yawancin lokaci yana haɓaka kwanaki da yawa, saboda haka mai haƙuri yana da lokaci don ɗaukar mataki. A wasu halaye, daga farkon ketoacidosis zuwa coma, 'yan awanni kawai suka wuce, saboda haka kuna buƙatar rage yawan sukari nan da nan bayan an gano shi. Don waɗannan dalilai amfani kawai mutum ne mai sauri . A matsayinka na babban doka, ana buƙatar sashi 1 don rage yawan ƙwayar cuta ta 2 mmol / L. Insuman. Don hana hypoglycemia, sukari a farkon matakin ya ragu zuwa 8. Yin gyaran jiki ga al'ada ana yin shi ne bayan 'yan sa'o'i, lokacin da tsawon allurar da ta gabata ta ƙare.

Tabbatar koya! Shin kuna tsammanin kulawa da kwayoyin hana daukar ciki da insulin shine hanya daya tilo da za'a kula da sukari? Ba gaskiya bane! Kuna iya tabbatar da wannan da kanku ta hanyar fara amfani da shi.

**** HOECHST MARION ROUSSEL Aventis Pharma Deutschland GmbH Sanofi-Aventis Deutschland GmbH / Sanofi-Aventis Gabas ta Duniya Marion Russel GmbH

Yanayi na musamman

• insulin-isophan (injinin halittar mutum) 3.571 mg (100 IU) Wadanda suka kirkiro: protamine sulfate - 318 μg, metacresol (m-cresol) - 1.5 MG, phenol - 600 μg, zinc chloride - 47 μg, sinadarin sodium dihydrogen phosphate dihydrate - 2.1 mg, glycerol 85% - 18.824 mg, sodium hydroxide (don daidaita pH) - 576 6g, acid hydrochloric (don daidaitawa da pH) - 246 μg, ruwa d / i - har zuwa 1 ml. insulin-isophan (injinin halittar mutum) 3.571 mg (100 IU) Wadanda suka kirkiro: protamine sulfate - 318 μg, metacresol (m-cresol) - 1.5 MG, phenol - 600 μg, zinc chloride - 47 μg, sinadarin sodium dihydrogen phosphate dihydrate - 2.1 mg, glycerol 85% - 18.824 mg, sodium hydroxide (don daidaita pH) - 576 6g, acid hydrochloric (don daidaitawa da pH) - 246 μg, ruwa d / i - har zuwa 1 ml.

Tsarin saki, abun da aka shirya da marufi

Sayi Insuman Bazal GT na iya kasancewa a cikin nau'i na dakatarwa don injections a karkashin fata a cikin sashi na 100ME / ml. Kowane kwalban gilashin ya ƙunshi 5 ml Insuman Bazal GT kuma yana rufe tare da fatar aluminium wanda aka rufe saman tare da filastik filastik don ƙara kariya. Akwai kwalabe 5 a cikin kayan kwali. Bugu da kari, ana samun maganin a cikin gilashin gilashin 3 ml. A wani ɓangare an rufe shi ta hanyar marufi kuma an rufe shi da aluminium, kuma a sashi na biyu - ta piston. Katin yana da kwallaye 3 na ƙarfe. Guda biyar irin wannan katako suna kunshe.

Aikin magunguna

Insulin yana saukar da glucose, yana tallafawa kirkirar sabbin mahadi kuma yana rage tasirin catabolic. Magungunan yana inganta motsi na glucose ta cikin sel kuma yana daidaita glycogen. Sakamakon gabatarwar a karkashin fata yana faruwa a cikin sa'a daya, ya zama mafi girman bayan sa'o'i uku kuma yana daga awa 11 zuwa 20. Tsarin T1 / 2 minti 5 ne, kuma a gaban gazawar renal, yana ƙaruwa sosai.

Ana amfani da insuman Bazal GT don ciwon sukari, wanda ke buƙatar gabatarwar ƙarin insulin.

Yawan abin sama da ya kamata

Doaukar magunguna fiye da kima, alal misali, ƙaddamar da ƙwayar wuce kima dangane da abinci ko makamashi da aka cinye, na iya haifar da mummunan bayyanar cututtuka na cututtukan jini, wanda zai iya zama haɗari na ainihi, har ma da mutuwa. Don lura da shari'ar cututtukan cututtukan ƙwayar cuta na ƙaramar rikitarwa, lokacin da mai haƙuri ya kula da tsabtataccen tunani, dakatar da amfani da abincin carbohydrate. Wataƙila kuna buƙatar daidaita sashi, canza dokoki da yadda yawan abincin yake da daidaita matsayin aiki a wasanni. Morearin rikitattun yanayi na hypoglycemia, wanda za'a iya haɗe shi da yanayin comotose, rikicewar rikicewar rikicewa ko rashin aiki a cikin ƙwaƙwalwar ƙwaƙwalwa, ana iya dakatar da shi ta hanyar gudanar da glucagon intramuscularly ko subcutaneously, ko gabatarwar babban taro na dextrose bayani ta hanyar jijiya. Ga yara, ƙaddara yawan kashi na dextrose yana dogara da nauyin jikinsu. Da zaran maida hankali na glucose ya tashi, yana iya zama buƙatar ɗaukar abincin carbohydrate kuma ku kula da likitan da yake halarta, tunda bayan farkon maganin alamun bayyanar cututtukan ƙwayar cuta, yana iya sake komawa. Lokacin kulawa da yara, yana da mahimmanci a kula da abubuwan da ke cikin glucose a hankali, saboda yana iya yiwuwa bayyananniyar alamun bayyanar yunwar rashin ƙarfi. A cikin lokuta na rashin ƙarfi na hypoglycemia na dogon lokaci bayan yin amfani da glucagon ko dextrose, yana da mahimmanci don sanya dropper tare da babban taro na maganin dextrose don guje wa lokuta na sake haifar da matsananciyar yunwar. Bugu da ƙari, yana da daraja la'akari da cewa wasu yanayi na iya buƙatar jigilar mutum zuwa sashin kulawa mai zurfi don tsananin kulawa da yanayinsa da kuma kula da dukkan matakan warkewa.

Hulɗa da ƙwayoyi

Abun hulɗa na Insuman Bazal GT tare da wasu kwayoyi na iya kama da wannan: 1. Tare da beta-blockers, clonidine, salhi lithium - raguwa a cikin tasirin hypoglycemic na miyagun ƙwayoyi. 2. Tare da ethanol - raguwa a cikin tasirin hypoglycemic na miyagun ƙwayoyi, haɓaka haɗarin haɓakar yunwar makamashi, da rage yawan abubuwan glucose zuwa ƙimar da ke barazana ga lafiyar da rayuwa. 3. Tare da pentamidine - ƙara haɗarin haɓakar yunwar makamashi, wanda zai iya shiga cikin hyperglycemia. 4. Tare da magungunan tausayawa - raguwa ko cikakkiyar cire alamun bayyanar cututtuka masu juyayi.

Haihuwa da lactation

A lokacin daukar ciki, yana da muhimmanci a ci gaba da ɗaukar Insuman Bazal GT. Yana da kyau a faɗi cewa insulin bashi da ikon shiga cikin mahaifa. Yana da mahimmanci a gudanar da iko na rayuwa a cikin lokacin daukar ciki ga wadanda a cikin su aka gano cutar sukari mellitus kafin daukar ciki, da kuma wadanda a cikin su ne mellitus na ciwon suga ke fara bayyana yayin daukar ciki. A cikin farkon farkon, buƙatar insulin na iya raguwa, amma akwai karuwa a cikin insulin a na biyu da na uku. Bayan haihuwa, bukatar insulin cikin hanzari yana raguwa, wanda hakan ke haifar da karuwar yiwuwar fuskantar yunwar makamashi. Ana buƙatar kulawa da hankali na glucose yayin daukar ciki kuma nan da nan bayan haihuwa. Lokacin da ake shirin yin ciki da kuma lokacin da ya faru, yana da mahimmanci a sanar da likitan halartar wannan. Kafin ka fara shirin, yakamata ka nemi shawara tare da likitan ka kuma gano dukkan alamu na yadda zaka shirya don juna biyu, kuma a farkon alamun hakan. Yana da mahimmanci a lura cewa yayin shayarwa babu takaddama don amfani da insulin, amma yin la'akari da daidaita yanayin insulin da abincin.

Yanayin ajiya

• ci gaba a cikin busassun wuri
• Adana cikin sanyi (t 2 - 5)
• nisantar da yara
• store a cikin duhu wuri

• Biogulin Tape U40, Isofan Insulin Kofin Duniya, Levulin L, Levulin N, Monotard, Humulin L, Humulin N

Matsakaici tsawon insulin mutum

Pharmacokinetics

A cikin mutane masu lafiya, T 1/2 na insulin plasma shine kimanin minti 4-6. A cikin marasa lafiya tare da gazawar na koda mai rauni, ya fi tsayi. Koyaya, ya kamata a lura cewa pharmacokinetics na insulin baya nuna sakamakon tasirinsa.

Alamomin Insuman ® Bazal GT

Ciwon sukari wanda ke buƙatar magani insulin.

Hanyoyin warkarwa

Tasirin hypoglycemic na Insuman Bazal an samu shi ne saboda sashin jikinta - insulin-isophan. Abubuwan da ke cikin tsarin sa da kayan sa sun yi kama da irin sinadarin da ake samarwa a jikin mutum. An samo shi ta hanyar injiniyan kwayoyin.

A miyagun ƙwayoyi nasa ne rukuni na kwayoyi na matsakaici tsawon aiki. Bayan gudanarwa, subcutaneously ya ɗaura wa wasu masu karɓa daga cikin membrane membrane na tantanin halitta, yana samar da takamaiman hadaddun da ke aiki da ci gaba cikin aiki. Yana rage glucose ta hanzarta jigilar sufuri, haɓaka sha, da hana haɗarin hanta, da kuma tafiyar matakai na rayuwa tare da kasancewarta.

Matsakaicin sakamakon da miyagun ƙwayoyi ke amfani da shi ya dogara da saurin wanda insulin ke cikin jiki, kashi, yankin allura, da hanyar gudanarwa. Saboda haka, insulin yana yin aiki musamman ba kawai a cikin masu ciwon sukari daban-daban ba, har ma a cikin haƙuri ɗaya.

Matsakaicin isofan dabi'u: farkon farawa - sa'o'i daya da rabi bayan allurar, mafi girman sakamako an bayyana shi a cikin tazara na 4-12 hours, tsawon lokacin aikin hypoglycemic - har zuwa 1 rana.

An rarraba maganin a fadin kyallen takura daban-daban, bai iya wucewa cikin madara da kuma ta cikin mara nauyi. Ana amfani dashi da yawa a cikin hanta da ƙodan. An fitar dashi cikin fitsari.

Hulɗa da miyagun ƙwayoyi

A yayin gudanar da insulin, yakamata a ɗauki insuman Bazal GT a zuciya cewa idan aka haɗa shi da wasu kwayoyi, canji a tasirin hypoglycemic ko gurbata tasirin warkewar wasu kwayoyi yana yiwuwa:

• Insulin na hypoglycemic sakamako yana haɓakawa kuma yana ƙaruwa lokacin da aka haɗu da magunguna na rage ƙwayar sukari, hanawar ACE, iMAO, Diyya, salicylates, anabolics, kwayoyi tare da hormones na maza, Fluoxetine, Fenfluramine, Ifosfamide, sulfonamides, Amphetamine da tetetamine.
• Haɗuwa tare da GCS, magungunan diuretic, corticotropin, Danazole, glucagon, hormones (estrogens, gestagens), sympathomimetics, abubuwan thyroid, abubuwan da aka samo na kwayoyin halittar sitothiazine, barbiturates da wasu sauran kwayoyi suna rage tasirin hypoglycemic na insulin.
• Lokacin da aka haɗu da BAB, Clonidine, salhi mai gishiri, aikin Insuman Bazal ba shi yiwuwa a hango ko hasashen: tasirin hypo- ko hyperglycemic tasiri na iya haɓaka.
• Ethanol yana aiki akan shirye-shiryen insulin kuma ba'a iya faɗi ba: sakamakon Insuman na iya ƙaruwa ko raguwa. Ya kamata a ɗauka a hankali cewa idan aka rage matakin glycemia na mai haƙuri, to, a ƙarƙashin ikon shaye-shayen kwayoyi ko kwayoyi, matakin sa na iya raguwa zuwa matakin mahimmanci, wanda zai iya haifar da barazana ga lafiyar da rayuwar masu ciwon sukari.

Side effects

Yayin amfani da kwayoyi, ya zama dole a la'akari da cewa insulin Bazal yana iya tayar da yanayin marasa kyau a cikin masu ciwon sukari.

Mafi yawan sakamako masu illa tare da maganin insulin. Yana tasowa lokacin da aka yi amfani da wani sashi wanda yafi sau da yawa girma akan buƙatar jikin insulin. Maimaita lamura mai ƙarfi na faɗuwar matakan glucose na taimakawa ga ci gaban rikicewar jijiyoyin zuciya, wanda za'a iya haɗa shi tare da tarko, coma. Tsayi da tsayi mai tsayi na iya tayar da mai haƙuri.

Idan raguwar ƙwayar glucose ya faru kwatsam, wannan na iya haifar da hypokalemia tare da rikitarwa na CVS da / ko cerebral edema.

Bugu da ƙari ga cututtukan jini, masu ciwon sukari suna da sauran tasirin da ba a so, waɗanda aka bayyana ta hanyar lalata gabobin ciki da tsarin:

• Bayyanar cututtukan ƙwayar cuta: anaphylaxis, halayen fata na fata, ƙwayar Quincke, bronchospasm, ƙirƙirar ƙwayar tsohuwar mutum (ana iya buƙatar sigar insulin).
• CCC: raguwa a cikin karfin jini.
• Hanyoyin tafiyar matakai: edema, yawan sodium a cikin jiki.
• Tsarin hangen nesa: raunin gani na yau da kullun, lalacewa ta ɗan lokaci na retinopathy, lalacewar jijiya ko ta ido, ya biyo bayan makanta na ɗan lokaci ko na dindindin.
• Fata da ƙwayar fata mai ɓoye: lipodystrophy (tare da kullun injections a wuri guda), a sakamakon - lalata ƙwayar insulin.
• Sauran rikice-rikice: redness a wurin allurar, itching, soreness, urticaria, bugu ko kumburi, kumburi.