Rosuvastatin sz > Magunguna

Yana daidaita matakan sukari na dogon lokaci
Maido da aikin samarda insulin

Masu karatun mu sunyi nasarar amfani da Aterol don rage cholesterol. Ganin shahararrun kayan wannan samfurin, mun yanke shawarar ba da shi ga hankalin ku.

Rosuvastatin SZ (Arewa Star) ya kasance ga rukuni na gumakan da ke da tasirin lipid.

Ana amfani da maganin yadda ya kamata don cututtukan da ke da alaƙa da ƙwaƙwalwar ƙwayar ƙwayar cuta, da kuma don rigakafin cututtukan cututtukan zuciya. Ana iya samun ƙarin cikakkun bayanai game da maganin a cikin wannan kayan.

A kan kasuwar magunguna, zaku iya samun magunguna da yawa waɗanda ke ɗauke da rosuvastatin abu mai aiki, a ƙarƙashin nau'ikan daban-daban. Rosuvastatin SZ ne ya samar da mai masana'antar cikin gida Severnaya Zvezda.

Tabletaya daga cikin kwamfutar hannu ya ƙunshi 5, 10, 20 ko 40 MG na alli rosuvastatin. Babban aikinta ya hada da sukari mai madara, povidone, sodium stearyl fumarate, primellose, MCC, aerosil da hydrogenhorophat na ruwa. Allunan Rosuvastatin SZ sune biconvex, suna da siffar zagaye kuma an rufe su da kwasfa mai ruwan hoda.

Abunda yake aiki shine mai hana HMG-CoA reductase. Ayyukanta yana da nufin ƙara yawan enzymes na hepatic LDL, inganta dissimilation na LDL da rage adadin su.

Sakamakon amfani da miyagun ƙwayoyi, mai haƙuri yana kulawa don rage matakin "mummunan" cholesterol kuma ya kara yawan "kyakkyawa". Ana iya lura da ingantaccen sakamako riga 7 kwanaki bayan fara magani, kuma bayan kwanaki 14 yana yiwuwa a cimma 90% na iyakar tasirin. Bayan kwanaki 28, ƙwayar lipid ta koma al'ada, bayan wannan ana buƙatar farfaɗo don maganin tsabta.

Mafi girman abun ciki na rosuvastatin ana lura da sa'o'i 5 bayan maganin baka.

Kusan 90% na kayan aiki masu aiki sun ɗaure zuwa albumin. Cirewa daga jiki yana gudana ta hanjin jiki da kodan.

Alamu da contraindications don amfani

An wajabta Rosuvastatin-SZ don ƙwayar ƙwayar ƙwayar cuta mai rauni da kuma rigakafin cututtukan zuciya.

A matsayinka na mai mulkin, yin amfani da wadannan allunan na bukatar bin man abincin hypocholesterol da motsa jiki.

Rubutun bayanin koyarwar yana da alamomi masu zuwa don amfani:

na farko, gidan homozygous ko hadewar hypercholesterolemia (a ƙari ga hanyoyin rashin magunguna)
hypertriglyceridemia (IV) a matsayin ƙari ga abinci mai gina jiki na musamman,
atherosclerosis (don hana sanya adadin ƙwayar cholesterol da kuma daidaita matsayin jimlar cholesterol da LDL),
rigakafin bugun jini, farfadowa daga jijiya da bugun zuciya (idan akwai abubuwa kamar tsufa, matakan C-reactive protein, shan sigari, kwayoyin jini da hawan jini).

Likita ya hana shan maganin Rosuvastatin SZ 10mg, 20mg da 40mg idan ya gano a cikin mara lafiya:

Kowane sakin jiki ga abubuwan aka gyara.
Rashin rauni na koda (tare da QC; Umarnin don amfani da miyagun ƙwayoyi

Allunan ya kamata a hadiye su duka tare da gilashin ruwan sha. Ana ɗaukar su ba tare da cin abinci ba a kowane lokaci na rana.

Kafin farawa da lokacin maganin ƙwayar cuta, mai haƙuri ya ƙi samfura kamar su kayan ciki (kodan, kwakwalwar mutum), yolks egg, naman alade, man alade, sauran abinci mai ƙima, gasa kaya daga gari mai tsabta, cakulan da Sweets.

Likita ya kayyade sashi na magunguna dangane da matakin cholesterol, manufofin magani da halaye na mutum na mai haƙuri.

Maganin farko na rosuvastatin shine 5-10 MG kowace rana. Idan ba zai yiwu a cimma sakamakon da ake so ba, ana ƙaruwa sashi zuwa kashi 20 cikin ɗari a ƙarƙashin tsananin kulawar ƙwararrun likita. Hakanan kulawa da hankali yana da mahimmanci yayin rubuta 40 MG na miyagun ƙwayoyi, lokacin da aka gano mai haƙuri tare da babban digiri na hypercholesterolemia da babban damar cututtukan zuciya.

Kwanakin kwanaki 14-28 bayan farawar magani, ya zama dole a sanya idanu kan yawan maganin lipid.

Babu buƙatar daidaita sashi na miyagun ƙwayoyi ga tsofaffi marasa lafiya da waɗanda ke fama da tabarbarewa na yara. Tare da polyformism na gado, halayyar myopathy ko kasancewar tseren Mongoloid, kashi na wakilin rage rage ƙwayar cutar bai wuce 20 mg ba.

Tsarin zafin jiki na adana magungunan ƙwayoyi bai wuce digiri 25 Celsius ba. Rayuwar shelf shine shekaru 3. Rike marufin a cikin wurin da aka kiyaye shi daga danshi da hasken rana.

Tasirin Gefuwa da Yarda

Duk jerin abubuwanda zasu iya faruwa wadanda suka faru lokacin amfani da miyagun ƙwayoyi an bayyana su cikin umarnin don amfani.

A matsayinka na doka, sakamako masu illa lokacin shan wannan magani suna da matukar wahala.

Ko da tare da bayyanar da mummunan halayen, suna da laushi kuma suna tafiya da kansu.

A cikin umarnin don amfani, an gabatar da jerin abubuwan sakamako masu illa:

Tsarin Endocrine: haɓaka cututtukan cututtukan ƙwayar cuta marasa ƙarfi na insulin-ciki (nau'in 2).
Tsarin rigakafi: Quincke edema da sauran halayen rashin hankali.
CNS: dizziness da migraine.
Tsarin Urinary: proteinuria.
Gastrointestinal fili: cuta dyspeptik, raunin epigastric.
Tsarin Musculoskeletal: myalgia, myositis, myopathy, rhabdomyolysis.
Fata: itching, amya, da tayi.
Tsarin Biliary: pancreatitis, babban aiki na transaminases hepatic.
Manuniyar dakin gwaje-gwaje: hyperglycemia, babban matakan bilirubin, alkaline phosphatase, aikin GGT, lalata ayyukan thyroid.

Sakamakon bincike na tallace-tallace, an gano halayen da ba su dace ba:

thrombocytopenia
jaundice da hepatitis
Stevens-Johnson ciwo
ƙwaƙwalwar ƙwaƙwalwar ajiya
na wuyan puppy,
ciwon sukari polyneuropathy,
gynecomastia
hematuria
kasawa numfashi da bushe tari,
arthralgia.

A wasu halaye, yin amfani da Rosuvastatin SZ tare da wasu magunguna na iya haifar da sakamako mara tabbas. Da ke ƙasa akwai abubuwan da ke tattare da tsarin kulawa na magani a lokaci ɗaya tare da wasu:

Ckersaukar da keɓaɓɓiyar furotin - haɓaka a cikin yiwuwar rashin lafiyar mama da kuma ƙaruwa a cikin adadin rosuvastatin.
Abubuwan kariya na kwayar cutar HIV - karuwar bayyanar abu mai aiki.
Cyclosporine - karuwa a cikin matakin rosuvastatin fiye da sau 7.
Gemfibrozil, fenofibrate da sauran fibrates, nicotinic acid - babban matakin abu mai aiki da kuma haɗarin kamuwa da cuta na myopathy.
Erythromycin da antacids waɗanda ke ɗauke da aluminum da magnesium hydroxide - raguwa cikin abubuwan da ke cikin rosuvastatin.
Ezetimibe - karuwa a cikin taro na aiki mai aiki.

Don hana haɓakar halayen marasa kyau saboda amfani da kwayoyi masu haɗaka guda ɗaya, ya zama dole a sanar da likita game da duk cututtukan da ke tattare da juna.

Farashi, sake dubawa da kuma alamun analogues

Tun da magungunan Rosuvastatin an samar da shi ta masana'antar sarrafa magungunan cikin gida "North Star", farashinsa ba shi da yawa. Kuna iya siyan magani a kowane kantin magani a ƙauyen.

Farashin kayan kunshin guda ɗaya wanda ya ƙunshi allunan 30 na 5 MG kowannensu shine rubles 190, 10 MG kowannensu shine rubles 250, 20 MG kowannensu shine rubles 400, kuma 40 MG kowannensu shine 740 rubles.

Daga cikin marasa lafiya da likitoci, zaku iya samun ingantattun ra'ayoyi da yawa game da magani. Babban ƙari shine araha mai araha da ƙarfin tasiri na warkewa. Koyaya, a wasu lokuta akwai maganganu marasa kyau waɗanda ke hade da kasancewar tasirin sakamako.

Eugene: “Na gano wani abin da ya saba da lafiyar kiba a cikin wani lokaci mai tsawo. A koyaushe ina gwada magunguna da yawa. Da farko ya dauki Liprimar, amma ya daina, saboda Farashinsa ya kasance babba. Amma kowace shekara Dole ne in sa masu juyawa don ciyar da tasoshin kwakwalwa. Daga nan likita ya umarce ni da Krestor, amma kuma bai sake daga magunguna masu arha ba. Na sami kaina analogues, daga cikinsu akwai Rosuvastatin SZ. Har yanzu ina shan wannan kwayoyin, ina jin dadi, cholesterol dina ya koma al'ada. "

Tatyana: “A lokacin rani, matakin ƙwayoyin cholesterol ya tashi zuwa 10, lokacin da al'ada take 5.8. Ya juya ga mai ilimin hanyoyin kwantar da hankali, kuma ya wajabta mini Rosuvastatin. Likitan ya ce wannan magani ba shi da karfi a hanta. Ina daukar Rosuvastatin SZ a yanzu, bisa manufa, komai yayi kyau, amma akwai guda ɗaya "amma" - ciwon kai wani lokaci damuwa. "

Ana samun kayan aiki mai aiki da rosuvastatin a cikin magunguna da yawa waɗanda masana'antun daban-daban suka samar. Kalamai sun hada da:

Akorta,
Kanta
Mertenil
Rosart,
Ro statin
Karin Matarina,
Rosuvastatin Canon,
Roxer
Rustor.

Tare da hypersensitivity na mutum zuwa rosuvastatin, likita ya zaɓi ƙarancin analog, i.e. wakili wanda ke dauke da wani bangaren aiki, amma yana samar da sakamako iri guda na rage kiba. A cikin kantin magani zaka iya siyan irin waɗannan kwayoyi:

Babban abu a cikin lura da ƙwayar cholesterol shine a bi duk shawarwarin ƙwararrun halartar, bi abinci kuma su jagoranci rayuwa mai aiki. Don haka, zai yuwu a magance rashin lafiyar kuma a hana matsaloli daban-daban.

An bayyana magungunan Rosuvastatin SZ daki-daki a cikin bidiyo a wannan labarin.

Yana daidaita matakan sukari na dogon lokaci
Maido da aikin samarda insulin

Binciken magungunan da ke rage cholesterol na jini

Tsarin cholesterol mai jini yana daya daga cikin sanadin cutar zuciya. Cholesterol abu ne mai kama da mai, babban kashi wanda ake samarwa a cikin hanta (kusan kashi 80%) kuma wani sashi yazo da abinci (kusan 20%). Yana ba da antioxidants ga jiki, yana ɗaukar sashi a cikin samar da kwayoyin horar da steroid da bile acid, yana daidaita ayyukan ayyukan juyayi, ya zama dole a cikin gina membranes.

Sannu a hankali, cholesterol yana tara jikin mutum ya zauna akan bangon jijiyoyin jiki irin na atherosclerotic plaques. Sakamakon haka, lumbar tasoshin jijiyar, yaduwar jini ya zama da wahala, kwararar iskar oxygen da abubuwan gina jiki ga kyallen da gabobin ciki har da kwakwalwa da zuciya, suna rushewa. Wannan shi ne yadda ischemia, infloction na myocardial da bugun jini na haɓaka.

Cholesterol yana shiga cikin jini kamar mahadi tare da furotin da ake kira lipoproteins. Latterarshen na nau'ikan HDL ne guda biyu (babban yawa) da LDL (ƙarancin ƙaranci). Na farko shine cholesterol lafiya. LDL mai cutarwa ne, ƙari ne wanda yake da haɗari ga jiki.

Wanene yake buƙatar ɗaukar kwayoyin magungunan ƙwayoyin cuta?

Likitoci suna da halaye daban-daban game da amfani da muggan kwayoyi, da yawa sun yi imani da cewa saboda yawan sakamako masu illa, amfani da su bai zama barata ba. Kafin ka fara shan irin waɗannan magunguna, kuna buƙatar yin ƙoƙarin cimma sakamako tare da taimakon abinci, ƙin mummunan halaye, motsa jiki. Koyaya, a wasu halaye, shan irin waɗannan magunguna wajibi ne. Wannan rukuni ya haɗa da mutanen da ke fama da cututtukan jijiyoyin zuciya, tare da ischemia tare da haɗarin kamuwa da cututtukan zuciya, tare da yanayin gado zuwa babban cholesterol, waɗanda suka sami bugun zuciya ko bugun jini.

Magungunan Cholesterol

Ana gudanar da magani ta amfani da kwayoyi na rukuni biyu: statins da fibrates. Don runtse cholesterol na jini, yawancin lokaci ana amfani da statins. Yau ita ce hanya mafi inganci. Ayyukansu shine cewa sun hana samar da mummunar cholesterol ta hanyar rage enzymes da suka dace da wannan. Don haka, sun hana samuwar manyan wurare da toshe hanyoyin jini, wanda ke nufin sun rage haɗarin cututtukan zuciya da na jijiyoyin jini.

Statins magunguna ne masu rage mummunar cholesterol kuma suna kara kyau. Bayan an ci su, matakin janar ya fadi da kashi 35-45 bisa dari, kuma matakin mummunan - kashi 40-60 bisa dari.

Ya kamata ku sani cewa waɗannan kwayoyi suna da sakamako masu illa, saboda haka kuna buƙatar shan su kawai a ƙarƙashin kulawar likitoci. Statins suna cutar da tsarin da yawa, yayin da rikice-rikice bazai iya bayyana nan da nan bayan gudanarwa ba, amma bayan wani lokaci. Daga cikin manyan illolin sakamako sune:

tsananin farin ciki
tashin hankalin bacci
ciwon kai
ƙwaƙwalwar ƙwaƙwalwar ajiya
parasthesia
amnesia
bugun zuciya
zawo ko maƙarƙashiya,
tashin zuciya
hepatitis
kama ido
maganin ciwon huhu
tsokoki na jijiyoyin jiki
rashin lafiyan halayen a cikin hanyar fata rashes da itching,
na gefe harshe,
take hakkin aikin jima'i,
cuta cuta na rayuwa.

daukar ciki, lokacin haihuwa da shayarwa,
yara ‘yan kasa da shekara 18
cutar hanta
cutar koda
cututtukan thyroid
mutum rashin haƙuri.

Statins da nau'ikan su

An ware su gwargwadon aikin abu wanda ke kawo cikas ga samarwar cholesterol. A cikin tsokoki na farko, wannan abun shine lovastatin. Daga baya, magunguna sun bayyana tare da fluvastafin, simvastain da pravastain. Sabbin magunguna na zamani tare da rosuvastatin da atorvastatin suna da tasiri sosai, rage LDL sosai a cikin jini da ƙara haɓaka cholesterol. Idan kwayoyi tare da lovastine sun rage LDL da 25%, to, sabon ƙarni na Allunan tare da rosuvastine - by 55%.

Statins sune kwayoyi masu zuwa:

Masu karatun mu sunyi nasarar amfani da Aterol don rage cholesterol. Ganin shahararrun kayan wannan samfurin, mun yanke shawarar ba da shi ga hankalin ku.

tare da lovastatin - “Choletar”, “Cardiostatin”,
tare da simvastatin - "Vasilip", "Ariescore", "Sinkard", "Simvastol", "Zokor",
tare da Fluvastatin - “Leskol Forte”,
tare da atorvastatin - “Tulip”, “Liptonorm”, “Atoris”, “Liprimar”, “Canon”, “Liprimar”,
tare da rosuvastatin - “Roxer”, “Mertenil”, “Tavastor”, “Crestor”, “Rosulip”.

Abin da kuke buƙatar sani game da statins?

An ɗauke su na dogon lokaci tare da tilas ɗin kula da likita.
Ana samar da cholesterol da dare, don haka ya kamata ku ɗauki wannan rukunin magunguna da yamma.
Idan kuna da rauni na tsoka da jin zafi, ya kamata ku nemi shawarar likitanku nan da nan.
Tare da taka tsantsan, an wajabta su ga mutanen da ke fama da cututtukan cataracts a kowane mataki.
Matan da suka isa haihuwa su yi amfani da rigakafin hana haihuwa yayin shan kwayoyin.
Yayin aikin jiyya, ya kamata a yi gwajin jini don tantance tasirin magani da kuma gano tasirin magunguna.

Wata rukunin kwayoyi da ke rage ƙwayar cholesterol sune eri abubuwan asali na fibroic acid. Wadannan kwayoyi ba su da tasiri a kan LDL fiye da statins. Suna haɓaka HDL da ƙananan matakan matsakaici na tsaka tsaki, ko triglycerides. Gabaɗaya, ana rage cholesterol da 15%, yayin da aka ƙarfafa bango na jijiyoyin bugun gini.

Wadannan magunguna masu zuwa na wannan rukunin:

Abubuwa masu cutarwa sun hada da:

fata tayi
rushewa daga cikin narkewa,
ciwon kai
rashin lafiyan mutum
cin gaban pancreatitis,
ƙara matakan hanta na hanta,
ci gaban thrombosis.

Kammalawa

Magunguna don tasirin cholesterol suna da yawa sakamako masu illa waɗanda zasu iya cutar lafiyar lafiya tare da tsawan amfani. Likitocin sun ki amincewa da nadin irin wadannan magungunan. Menan samari (yearsan shekaru 35) da kuma matan masu haihuwa da waɗanda ba su da saukin kamuwa da cututtukan zuciya, an shawarce su da rage ƙwaƙwalwar su ba tare da magani ba, wato daidaita tsarin abincinsu da salon rayuwarsu. Koyaya, allunan ba koyaushe za'a iya rarraba su da su. Yana da mahimmanci a tuna cewa yakamata a sha su kamar yadda likitan ya umurce shi. Baya ga shan magunguna, kuna buƙatar canza salon rayuwarku, wato, bi abinci, motsa jiki, ware shan sigari.

Rosuvastatin - alamomi don amfani

Me aka ba da rosuvastatin? Jerin cututtukan cututtuka da yanayin ƙanana kaɗan:

Hypercholesterolemia (nau'in IIa, wanda ya hada da famteal heterozygous hypercholesterolemia) ko hadewar hypercholesterolemia (nau'in IIb) a matsayin ƙari ga abincin,
Iyali na hyzycholesterolemia a matsayin ƙari ga abincin,
Na jijiyoyin zuciya, cerebral ko na koda na atherosclerosis, eclusive artery lumen,
Atherosclerosis na arteries na ƙananan ƙarshen, ciki har da ciwo na Lerish, hauhawar jini, tare da haɓaka matakin furotin na C-reactive a cikin tarihin iyali,
Hypertriglyceridemia (nau'in IV a cewar Fredrickson),
Jiyya na lalatawar hanji da ta kwakwalwa, farawa daga lokacin da muke fama,
Yin rigakafin infarction na zuciya da bugun jini.

Kamar yadda kake gani, bai kamata ka ɗauki Rosuvastatin kamar allunan cholesterol da zaka iya amfani da kanka ba.

Sashi na ajali - yadda ake ɗaukar rosuvastatin?

Ana ɗaukar allunan Rosuvastatin a baki da ruwa. Yawan shawarar farawa ga manya shine kwamfutar hannu 1 na rosuvastatin 10 - 1 lokaci kowace rana.

Dangane da sakamakon binciken, za a iya ƙara yawan zuwa 20 mg bayan makonni 4 (ba a baya ba).

Theara kashi zuwa 40 MG na rosuvastatin zai yiwu ne kawai a cikin marasa lafiya da ke cikin raunin hypercholesterolemia da babban haɗarin rikicewar zuciya (musamman a cikin marasa lafiya tare da familial hypercholesterolemia) tare da karamin tasirin warkewa a kashi na 20 MG, kuma batun kulawar likita.

Yin rigakafin cututtukan CCC
A cikin nazarin sakamakon rigakafin rosuvastatin, an yi amfani da kashi 20 na MG / rana. Ya kamata a la'akari da shi - yawan farawa ya kamata ya zama ƙasa kaɗan kuma a tsara shi yayin yin la'akari da alamun masu haƙuri daga 5 zuwa 10 MG / rana.

Siffofin

Ga marasa lafiya daga shekara 70, ana ba da magani tare da rosuvastatin a cikin farawa na 5 MG / rana. Ana aiwatar da gyaran kashi ne ta hanyar likita, idan ya cancanta, yin la'akari da adadin cholesterol da kuma yiwuwar cututtukan cututtukan cututtukan zuciya.

Lokacin amfani da rosuvastatin a cikin kashi 40 MG, ana bada shawara don saka idanu akan alamun alamun aikin. Contraarin contraindications zuwa rosuvastatin mai yiwuwa ne.
A mafi yawancin halayen, proteinuria yana raguwa ko ya ɓace yayin jiyya kuma baya nufin faruwar cutar ko ci gaba da cutar koda.

A cikin marasa lafiya tare da hypercholesterolemia saboda hypothyroidism ko ciwo nephrotic, ya kamata a gudanar da maganin manyan cututtuka kafin a yi jiyya tare da rosuvastatin.

Jimlar bita: 27 Rubuta bita

Ina da cholesterol 6.17 - an umurce ni da wadannan allunan rosuvastatin, amma yayin da na karanta umarni, akwai irin waɗannan contraindications cewa yana da ban tsoro har na fara ɗauka. Wataƙila da wuri a gare ni in ɗauki irin waɗannan ƙwayoyi tare da irin wannan cholesterol.

Elena, gwada cin abincin farko, idan baku gwada ba tukuna. Ku ci ƙarin ganye ... Satin ita ce makoma ta ƙarshe.

menene hanya mafi kyau don ɗauka ??

Asauki kamar yadda aka rubuta a cikin umarnin don amfani, ko kuma kamar yadda likitan da ya rubuta rosuvastatin ya nuna.

Kwanan nan Rosuvastatin ya fara da likita ta tsara shi. Sakamakon gwajin zai nuna aikinsa ba da daɗewa ba, amma a madadin Rosuvastatin Ina so in faɗi cewa ba shi da alamun munanan halayen, kamar daga wasu magunguna.

An sami ɗan ƙarfe smackic a cikin bakin da goosebumps, kodayake kashi 10mg magani ne mai matukar tasiri da tsada.

Na dauki rosuvastatin-s3 40 MG a shekara da suka gabata (likita ya wajabta shi) akwai babban cholesterol, wata daya daga baya ya zama al'ada. Ya zama dole a yi kasa da hakan.

Na kuma dauki rosuvastatin-sz, a kashi 10 na magani, kuma na damu sosai game da tasirin sakamako - Har yanzu ban sami isasshen matsaloli tare da hanta don samun cholesterol mai yawa, amma na damu a banza - Na ji dadi sosai, cholesterol dina ya ragu.

Lokacin da kuka ga cewa umarnin suna da sakamako masu illa, wannan yana nuna cewa an yi nazarin magungunan dalla-dalla kuma an gudanar da binciken asibiti sosai. Kada kuyi tunanin cewa sayen wani magani na "al'ajiban" tare da ɗan takaitaccen koyarwa da kuma nuni "ga duka cututtuka" zai zama gaskiya. Kasuwancin kantin magani shine mafi girma a cikin duniya kuma yana buƙatar "inganta". Na fi kyau in sayi gida, aka tabbatar, kuma mafi mahimmanci, Rozuvastatin-SZ ne na likita, wanda na yi watanni 7 da suka gabata. Sakamakon haka, ƙwayar cholesterol ta ragu daga 6.9 zuwa 5.3. Kawai kada kuyi magani kai - da farko ga likita!

Rosuvastatin ya dace sosai da babban cholesterol, amma idan hypercholesterolemia yana da matsakaici, zaka iya samun sauƙin ci tare da cin abinci da dibicor, don haka ka guji tsawon lokaci kuma ba ingantaccen sakamako na steatin a jiki ba.

Rosuvatin-sz (kamar yadda yake a cikin hoto) shine mafi arha ga duk lambobi. Na tabbatar - yana aiki. Daga cikin sakamako masu illa - rashin jin daɗi a farkon farkon yarda, to, komai ya tafi. Cholesterol daga 7.5 zuwa 5.3 cikin watanni 1.5.

Kakata ta sha rosuvastatin sz, kuma an umma mahaifiyata atorvastatin sz, ba ta jin tsoron sha, saboda idan ba ku sha ba, komai zai iya ƙare da mummuna. Af, magungunan ba su da tsada.

Kyakkyawan ƙwayar cuta, rosuvastatin-sz, Na tabbatar ta misali na mutum - a cikin watan amfani, cholesterol ya faɗi daga 8.8 zuwa 5.1, kuma wannan cikin rashin abinci (Na tuba, ba zan iya yin biyayya ba). Sau da yawa nakan sami ra'ayin cewa baƙin kasashen waje sun fi kyau, ni ba mai fada ba ne, amma dai ga alama har yanzu magungunanmu suna iya yin, aƙalla ba masu rikitarwa ba.

Na dauki atorvastatin-sz na dogon lokaci, sashi ba shi da yawa, amma baya barin kwalakwalar zuwa lambobi masu hatsari.

Na yarda da ingantattun sake dubawa game da rosuvastatin-sz! Na yi fama da cholesterol tsawon shekaru biyar, na gwada abubuwa daban-daban - na shigo da namu. Yanzu, hakika, waɗanda aka shigo da su ba zasu iya wadatar su da komai ba, kawai rosuvastatin-sz ya shigo lafiya daga waɗanda suke cikin gida, kuma mafi mahimmanci, galibi yana cikin kantin magani

A 33, a binciken likita, ta gano gaba daya ba zato cewa an tashe cholesterol! Gaba ɗaya 8.1, mara kyau - 6.7! Lambobin ban tsoro. Na fara shan rosuvastatin-sz, na ji tsoro sosai cewa za a sami sakamako. A cikin kwarewata, miyagun ƙwayoyi na al'ada ne, mafi mahimmanci shine lowers cholesterol.

Na kasance ina ɗaukar rosuvastatin-sz tsawon shekaru 3. Bayan bugun zuciya, an sanya su ne domin rayuwa. Babu wasu sakamako masu illa, sai dai da farko akwai masu yawan zafin rai, cholesterol yana kasancewa 4.5-4.8. Faranta musu da farashi.

Magunguna mai ban mamaki shine rosuvastatin. An umurce ni da rosuvastatin-sz, ya fi rahusa fiye da sauran, amma zan iya cewa na sha shi don wata na uku kuma na ji dadi. Babu wasu sakamako masu illa, kodayake zan fada maka labarin tsoro. Cholesterol ya ragu daga 8.5 zuwa 4.3.

Ya fara shan rosuvastatin-sz bayan rukuni biyu na atorvastatin - likita ya ba da shawarar canzawa zuwa mafi magungunan zamani. Cholesterol a bayyane yake al'ada. Ban lura da sakamako masu illa ba. Faranta musu da farashi.

Hakanan zan iya yaba rosuvastatin-sz, kazalika da masu sharhi a sama - farashin ya taɓa ni musamman, ba shakka ban san bambanci da sauran kwayoyi ba, kuma Russia sun yarda da shigo da su, duk suna aiki iri ɗaya. Sabili da haka, zaku iya zaɓar farashi.

Akwai hanyoyin mutane, amma ba sa aiki. Jikinmu da kansa yana samar da cholesterol, ko kuma akasarin shi. Kuna iya rage shi tare da mutum-mutumi, alal misali, rosuvastatin-sz iri ɗaya, wanda aka bayyana a sama. Ka'idar aiki - miyagun ƙwayoyi sun hana samar da cholesterol a cikin hanta (wannan shine cikakkiyar bayani, karanta wuraren bayanan martaba). Kada ku manta da likitoci kwata-kwata, kawai zasu zabi magani da ya dace.

Abin da ya sa ya sauƙaƙa ɗaukar gumaka shine cewa akwai kwamfutar hannu guda ɗaya kawai a rana. Ban tabbata ba idan kana da cholesterol har zuwa 7 ya zama dole, amma idan ya fi hakan, to lallai ya zama dole. Atherosclerosis, bugun jini da bugun zuciya sun fi mummunar tsoro fiye da tsoron tasirin tunani a hanta da kodan. Af, bayan bugun zuciya, an tsara statins don rayuwa kuma babu komai, mutane suna rayuwa cikin farin ciki koyaushe. Ni da kaina na tsayayya da magunguna masu tsada, idan akwai rahusa, da kuma analogues na cikin gida, don haka idan an umurce ku da statins, gwada tambayar likitan ku game da rosuvastatin-sz. Kuma sannan an nada gicciye daban-daban da masu ba da izini a cikin dubun dubatar kowace kunshin, amma akwai daidai wannan abu a 400 rubles.

Gaya mini, menene al'ada a cikin jinin cholesterol a cikin tsofaffi, kimanin shekara 67? Gaskiya, da na yau da kullum ne 3.5)

A wannan zamanin, ana ganin tsarin ya kasance daga 4.4 zuwa 7.8. Amma yana da kyau a kiyaye ƙwayar cholesterol a cikin iyakar ta. Misali, a shekaru 30 na haihuwa, ka'idar ta kasance daga 3.3 zuwa 5.9. Idan cholesterol ya yi girma, an rubuta rubutattun abubuwa. Misali, guda rosuvastatin-sz wacce suka rubuta a sama.

Na ɗauka analog, rosuvastatin-sz a cikin adadin 40 MG, don haka ya juya don ɗaukar kwamfutar hannu guda ɗaya kawai a rana, wanda ya dace sosai. A farashi mai ƙanƙanta da ƙasa da rosuvastatin da aka shigo da shi.

Watanni shida bayan sun yi aikin tiyata, sun sami filaye a cikin wasu jiragen ruwa guda biyu Rosuvastatin yana shan wannan lokacin 20 mg, Da farko, kula da hanta da koda, baya, tsokoki na kirji, wataƙila babban adadin? Kuma gaya mani, a kalla wani ya warke daga plaque wani lokaci tare da wannan magani…. . kuma bayan nawa?

Na dade ina ɗaukar rosuvastatin, kimanin shekaru 4. Ba na yin korafi game da cholesterol 5.9-6.2 ba ya tashi a sama, matsin lamba ya ragu, ya kasance sau 160-170, yanzu 130-140. A cikin watannin farko, sakamakon ya kasance sananne musamman tunda nessarfi na numfashi ya fara tafiya tare da matsanancin ƙoƙari na jiki da baƙin ciki tare da kowane mako ya zama ƙasa. Na gaba, kamar kowane watanni shida, kulawa da jini.

Umarnin don amfani da rosuvastatin

Magungunan Rosuvastatin (Rosuvastatin) yana da tasirin lipid, yana ɗauke da abu guda mai aiki. Kamfanoni da yawa suna samar da maganin - Canon na Rasha da North Star, da Teva na Isra'ila. Yin amfani da miyagun ƙwayoyi ya barata tare da ƙara yawan lipids da cholesterol a cikin jini. Kayan aiki yana daidaita daidaituwar waɗannan abubuwa, dawo da lafiyar mutum.

Abun ciki da nau'i na saki

Rosuvastatin ana samuwa ne kawai a tsarin kwamfutar hannu; babu wasu nau'in sakewa. Fasali na abun da ke ciki:

Round light allunan ruwan hoda cikin farin

Taro na rosuvastatin a cikin nau'in gishiri na alli, mg da pc.

Red dye carmine, microcrystalline cellulose, triacetin, sitaci pregelatinized, magnesium stearate, titanium dioxide, colloidal silicon dioxide, hypromellose, lactose monohydrate

Fakoki na guda 10., 3 ko 6 a kowane fakitin

Magunguna da magunguna

Magungunan lipid-ragewan Rosuvastatin shine mai hana inzirin na enzyme gamma-glutamyltranspeptidase, wanda ke inganta bayyanar mevalonate, mai haɓaka cholesterol. Abubuwan da ke amfani da ƙwayoyi suna aiki a cikin hanta, akwai haɗin cholesterol da catabolism na lipoproteins na kowane yawa. Magungunan yana kara yawan masu karɓuwa ga ƙarshe a kan ƙwayoyin hanta, yana ƙaruwa da haɓakar abincinsu, wanda ke hana ƙirar lipoproteins mai yawa sosai.

Da zaran cikin jini, rosuvastatin inhibitor da mai jigilar kwayar cutar efflux ya kai ga yawan maida hankali bayan sa'o'i biyar.Zamansa wanda ya shafi cytochrome isoenzymes yana faruwa a hanta, kuma yana daurewa da albumin da kashi 90%. Bayan kawar, an kirkiro metabolites a cikin hanta wadanda ke aiki kaɗan, basu shafi jigilar kwayoyin halittar kwayoyin halitta da polypeptides, creatinine da keɓancewar phosphokinase, da kuma cholinerol biosynthesis.

Kusan dukkan maganin yana barin hanjin cikin bai canza ba, saura - tare da kodan da fitsari. Rabin rayuwar shine awanni 19. Magungunan magunguna na kayan aiki na abun da ke ciki ba ya shafa ta hanyar jinsi, shekaru, amma akwai bambance-bambance don isa mafi girma a cikin wakilan sauran jinsi (sau biyu a cikin Mongoloids da Indiya fiye da na Caucasians da Negroids).

Abubuwa masu aiki na rosuvastatin

Aiki mai aiki na inhibitor abun da ke ciki yana rage matakan girma na cholesterol, triglycerides, low dansity lipoproteins, apolipoprotein, yana ƙara yawan taro na lipoproteins mai yawa. A sakamakon haka, a cikin marasa lafiya tare da hypercholesterolemia, bayanin martaba na lipid yana inganta kuma ƙirar atherogenicity ta ragu. Sakamakon warkewa na miyagun ƙwayoyi yana tasowa a cikin mako guda, ya kai matsakaici zuwa watan far. An nuna magungunan don manya tare da hypercholesterolemia tare da ko ba tare da triglyceridemia ba, tare da halayen bugun jini ko bugun zuciya.

Alamu don amfani

Babban dalilai don amfani da miyagun ƙwayoyi Rosuvastatin sune cututtukan da ke hade da haɓakar lipid. Alamu:

na farko hypercholesterolemia, gami da familial heterozygous, ko gauraye hypercholesterolemia a hade tare da abinci, motsa jiki,
iyali na hyzycholesterolemia a hade tare da abinci da ragewar rage kiba,
sabar, kamar,
rage gudu na atherosclerosis,
rigakafin farko na bugun jini, bugun zuciya, farfadowa na jijiya ba tare da alamun cututtukan zuciya ba, amma tare da hadarin ci gabanta (tsufa, hauhawar jini, shan taba, tarihin dangi).

Yadda ake ɗaukar rosuvastatin

Allunan ana daukarsu a baki, a wanke da ruwa. Ba za a iya cutar da su ko murƙushe su ba. Ana shan miyagun ƙwayoyi a kowane lokaci na rana, ba shi da haɗin abinci. Kafin fara magani, mai haƙuri dole ne ya bi abinci tare da ƙuntatawa abinci dauke da fats mai cutarwa. Maganin farko na marasa lafiya shine 5 ko 10 MG na rosuvastatin sau ɗaya / rana. Bayan mako hudu, sashi na iya karuwa.

Ana amfani da kashi 40 na ƙwayar rosuvastatin tare da taka tsantsan, ana buƙatar saka idanu na musamman ga irin waɗannan marasa lafiya. Kowane makonni 2-4 na ilimin likita, marasa lafiya suna ba da gudummawar jini don tantance sigogin lipid. Ga tsofaffi marasa lafiya, ba a daidaita sashi ba, tare da gazawar cutar koda, shan allunan an hana su. Don rashin ƙarfi na hepatic matsakaici, kashi na iya wuce 5 MG.

Umarni na musamman

Rosuvastatin yana tasiri sosai akan aikin hanta da kodan, sauran tsarin jikin mutum, don haka farjin aikin yana tare da umarni na musamman. Dokokin shan kwayoyin:

Babban allurai na ƙwayar cuta na iya haifar da turular protein na ɗanɗano. Yayin aikin jiyya, yakamata a kula da aikin da ƙodan.
Allurar da ta wuce 20 MG / rana zai iya haifar da myalgia, myopathy, rhabdomyolysis, da sauran karkacewa a cikin aiki na tsarin musculoskeletal. Idan marasa lafiya suna da dalilai masu haɗari don haɓakar irin waɗannan cututtukan, an tsara maganin tare da taka tsantsan.
Idan yayin aikin jiyya ba zato ba tsammani yana jin zafi, rauni ko yaushi saboda zazzabi ko zazzabi, buƙatar gaggawa don ganin likita. Cases na rigakafi-matsakaici myopathy (tsoka rauni, ƙara yawan enzyme aiki) da wuya faruwa. Don kawar da alamun mummunan bayan bincike na serological, ana aiwatar da aikin rigakafi.
Shan allunan rosuvastatin ba zai haifar da karuwa ba a cikin kasusuwa.
Idan hypercholesterolemia ya haifar da hypothyroidism ko ciwo nephrotic, to, dole ne da farko ku kawar da cututtukan da ke tattare da cutar, sannan kuma ku ɗauki Rosuvastatin.
An soke magungunan tare da haɓaka ayyukan hepatic transaminases sau uku.
Magungunan sun ƙunshi lactose, sabili da haka an hana aikin kulawarsa idan akwai rashin haƙuri a cikin lactose, rashi lactase, glucose-galactose malabsorption.
Tsarin maganin statin na dogon lokaci na iya haifar da cututtukan huhun ciki, wanda ke bayyane ta ragewar numfashi, tari, rauni, nauyi, da zazzabi. Idan aka gano waɗannan alamun, ana soke warkewar cutar.
Yayin kulawa tare da magani, jin rauni da rauni na iya faruwa, sabili da haka, an bada shawara don guji sarrafa abubuwa da abubuwan hawa.
Lokacin rubuta magani, yakamata a yi la’akari da ƙwayoyin halittar jini.

A lokacin daukar ciki

Yin amfani da rosuvastatin an hana shi cikin ciki. Idan macen da take haihuwar tana haila tana shan kwayoyin, to yakamata tayi amfani da hanyoyin ingantattun maganin hana haihuwa. Lokacin da ake bincika ciki, ya kamata a dakatar da maganin nan da nan.Ba a sani ba ko kayan aikin da ke cikin ruwan nono, amma an soke amfani da allunan na tsawon lokacin shayarwa (noctation).

A lokacin ƙuruciya

Yin amfani da allunan rosuvastatin ga yara da matasa masu shekaru 18 da haihuwa sun saba. Irin wannan haramcin yana da alaƙa da tasirin ƙwayar magani a hanta, wanda zai iya haifar da jujjuyawa ko mummunar ɓarna a cikin aikin wannan sashin jiki ko duk jikin. Wa'adin likita bayan shekaru 18 yakamata a gabatar da shawarar likita da cikakken bincike.

Idan akwai rauni na koda da hepatic aiki

Marasa lafiya da ke fama da matsanancin yanayin ƙarancin abinci yana hana ta kowane sashi. Ana amfani da kashi 40 na yau da kullun na rosuvastatin don amfani a cikin marasa lafiya tare da gazawar matsakaiciyar matsakaici, ana amfani da sashi na 5, 10 da 20 MG tare da taka tsantsan. Game da gazawar ƙwayar renal, ya kamata a kula da hankali tare da 40 MG na abu.

Hulɗa da ƙwayoyi

Ana nuna Rosuvastatin da tasiri mai tasiri akan aikin wasu kwayoyi. M haduwa da ma'amala:

Haɗin maganin tare da Cyclosporine, masu kare kariya daga ƙwayar cuta na mutum (HIV), ƙwayar cuta a cikin kashi 40 MG, inducers na cytochrome substrate an haramta.
Hadin magunguna na 5 MG tare da gemfibrozil, wakilai na hypolipidem, fenofibrate, nicotinic acid, fluconazole, digoxin, maganin rigakafi.
An yi taka tsantsan don haɗuwa da rosuvastatin da ezetimibe.
Tsakanin ɗaukar allunan da dakatarwar antacids waɗanda ke kan aluminium ko magnesium hydroxide, awa biyu ya kamata ya shuɗe, in ba haka ba amfanin rabin abin ya ragu.
Haɗin maganin tare da erythromycin yana ƙara yawan ƙwayar rosuvastatin a cikin ƙwayar jini ta uku.
Haɗin maganin tare da fusidic acid na iya haifar da haɓakar rhabdomyolysis.
Adadin Rosuvastatin ana daidaita shi lokacin da aka haɗa shi da Ritonavir, Atazanavir, Simeprevir, Lopinavir, Clopidogrel, Eltrombopag, Darunavir, Ketoconazole. Haɗuwa da Tipranavir, Dronedarone, Itraconazole, Fosamprenavir, Aleglitazar, Silimarin, Rifampicin, Baikalin suna buƙatar irin wannan aikin.
A miyagun ƙwayoyi ƙara excretion na baka hana haihuwa dangane da hormones ethinyl estradiol da norgestrel.

10 sharhi

Don halartar masu halartar zuciya don tabbatar da cewa mai haƙuri ba ya haifar da bala'i na kwatsam - ciwo na jijiyoyin zuciya, myocardial infarction ko ischemic bugun jini, likita dole ne a hankali kula da matakin jimlar da "mummunan" cholesterol, wanda ya haɗa da LDL (low density lipoproteins ) A cikin wannan an taimaka masa ta hanyar shawarwarin gida, da kuma shawarwarin Societyungiyar Turai ta Cardiology.

Ya ce marasa lafiya da ke da haɗarin haɓakar rikice-rikice na zuciya da jijiyoyin jini ya kamata su yi ƙoƙari don tabbatar da cewa matakin LDL bai wuce 3 mmol a kowace lita (tare da haɗari na matsakaici), ƙasa da 2.5 tare da matsakaita da ƙasa da 1.8 mmol / l tare da babban matakin hadarin (alal misali, a gaban bugun zuciya ko bugun jini a da).

Don aiwatar da waɗannan tsauraran shawarwari a cikin tsofaffi marasa lafiya (bala'i na jijiyoyin jini, duk da "farfadowa da sauri" duk da haka, abubuwa ne na tsofaffi), ana buƙatar yin abubuwa da yawa. Idan canza yanayin abinci da salon rayuwa har yanzu yana da sauƙi a yi a ƙuruciya, to, dattijo, galibi yana kwance, yana ɗaukar nauyi mai yawa da cututtuka daban-daban (ciwon sukari), yana da wuya a sami ƙimar abubuwan ƙima. Sabili da haka, magungunan da ke daidaita metabolism mai a cikin irin wannan marasa lafiya sune tushe da tushe na rigakafin bala'in jijiyoyin jiki da rikitarwa.

Daga cikin wadannan kwayoyi, alkaluman da ke hana HMG - CoA - reductase enzyme ana ɗaukarsu jagorori ne. A zamaninmu akwai da yawa, akwai ƙarni da yawa na statins, kuma ingancinsu ya bambanta sosai. Don haka, ana kiran simvastatin (“Vazilip”) ga magungunan ƙarni na farko mafi arha. Wakilin mutanen ƙarni na biyu shine fluvastatin (Leskol), na ukun - atorvastatin (Liprimar). Magunguna mafi inganci da na zamani sun haɗa da rosuvastatin. Wannan maganin yana ga mutum-mutumi na hudu, kuma asalin maganin da ya fara shiga kasuwar shine Crestor.

A halin yanzu, a cikin kantin magunguna na Rasha zaka iya sayan ba kawai rosuvastatin na asali ba, har ma analogues masu yawa - kusan magunguna 10 daban-daban, kuma idan kun ƙidaya abubuwan da ba a sa alamarsu ba (suna da kasuwanci), to yawan masu kera wannan magani zai wuce kamar dozin. Kasuwanci da dabara suna jin buƙatar, kuma babu wanda zai iya samar da magani mara amfani. Menene ke sa Rosuvastatin ta zama mai ban sha'awa, kuma ta yaya yake aiki?

Hanyar aikin rosuvastatin

asali magani da kuma analogues

Kamar yadda aka ambata a sama, duk statins yana hana HMG - CoA - reductase, wanda ke taka muhimmiyar rawa a cikin ƙwayar cholesterol da guntun "mummuna". Amma kwayoyin rosuvastatin an canza su ta wannan hanya ta zama mai narkewa a cikin kitse, sabili da haka yana da mafi girman kusanci ga enzyme da ake so (sau 4 fiye da ƙwayoyin halitta na jiki). Saboda wannan, haɗin rosuvastatin tare da mai karɓar wanda ake so yana faruwa da sauri, ba tare da jinkiri ba kuma “a bi”. Sakamakon haka, an rage ƙwayar mevalonic acid, mai hana ƙwaƙwalwar ƙwayar cuta, a cikin hanta.

Kwayoyin hanta suna ba da amsa ga wannan tare da karuwar yawan masu karɓar ƙwayoyin cholesterol a kan membrane, “mara kyau” gutsuttsuran ƙwaƙwalwa suna da kyau a kama su kuma a cire su daga jini.

Bayan shan miyagun ƙwayoyi, mafi girman hankali a cikin jini ya tara bayan 5 - 5.5 sa'o'i bayan kashi ɗaya, kuma tare da tsawanta amfani, daidaituwa mai daidaituwa yana faruwa wanda ya faru 4 hours bayan amfani. Wannan yana da mahimmanci, tunda karɓar liyafar ta dogara da shi. Dangane da fitowar jiki, saurin sa bai dogara da maganin ba kuma yana ɗaukar dogon lokaci - har zuwa awanni 20.

Umarnin don amfani da tsarin kulawa

Asali rosuvastatin, Krestor, duk da haka, kamar sauran sauran gumaka, ana samun su ta hanyar kwamfutar hannu kawai. Akwai sashi na 10, 20 da 40 mg. Wasu kwayoyin halittar suna da karancin magani. Don haka, "Mertenil" wanda "Gideon Richter" ya samar, Hungary, yana da ƙarin "fara" kashi 5 MG.

A dacewa, magungunan da abincin abinci basu da alaƙa ta kowace hanya. Kuna iya ɗaukar Rosuvastatin akan komai a ciki, lokacin ko bayan abinci.

Amma game da sashi - an zaɓi shi daban-daban, kuma tushen ƙara yawan ƙwaƙwalwa shine nazarin sarrafa matakan matakin lipids na jini, tare da cikakkun alamu. Binciken da ake amfani da ma'ana guda ɗaya - duka cholesterol - ba shi da tasiri.

Sigar farko na rosuvastatin yawanci 10 MG ne, wani lokacin, tare da ƙarancin haɗarin haɗari da rashin rashi mai yawa, an tsara 5 MG. Hayar da kashi an yarda ba a farkon wata daya daga baya. Matsakaicin adadin shine 40 MG, kuma zaka iya tashe shi zuwa wannan alamar kawai akan alamomi: tsananin hypercholesterolemia mai rauni ko kuma haɗarin gaske. Babu matsala ya kamata ka hanzarta sanya 40 MG ga wani mara lafiya wanda ya fara ɗaukar statins. Bayan makonni 2 ko wata na shigarwa, bincike mai zurfi game da lipids na jini kuma ana aiwatar da sigogi na asibiti da kuma ƙirar ƙwayar cuta, kuma likita ya yanke shawara game da ƙarin dabarun haƙuri.

Contraindications da sakamako masu illa

Tare da ingantaccen kuma ingantaccen magani na magani, kuma musamman tare da ka'idodi na karuwa a hankali, rosuvastatin ya nuna amincinsa a cikin mafi yawan lokuta a cikin aikin likita. Tabbas, wannan maganin shima yana da abubuwanda basa haifarda illarsa, wadanda suke dogaro da kai. Amma rosuvastatin yana da peculiarity - ba kawai sakamako masu illa suna dogara da kashi ba, har ma da contraindications. Ga marasa lafiya waɗanda zasu iya ɗaukar 10 MG na dogon lokaci, koyaushe ba zai yiwu a ƙara kashi zuwa 20 ba, har ma fiye da haka zuwa 40 MG, alal misali, magani a cikin kashi na fiye da 5 MG shine contraindicated na:

marasa lafiya da kumburi da aiki a cikin hanta da kuma kara matakan transaminases (cholangitis, hepatitis),
cikin rauni na koda
tare da myopathy,
idan mai haƙuri ya karɓa kuma ya kasa warware cyclosporine,
a cikin mata masu juna biyu, masu shayarwa da yara.

Amfani da 40 MG na rosuvastatin an hana shi, ban da cututtukan da ke sama, kuma a cikin waɗannan lambobin:

tare da gazawar renal tare da sharewar creatinine a kasa da 60 ml minti daya
a gaban myxedema da hypothyroidism,
a gaban cututtukan tsoka a cikin anamnesis ko a cikin dangi (myasthenia gravis, myopathy),
shan giya
Mongoloid marasa lafiya (fasali na rayuwa),
haɗin haɗin fibrates.

Ta halitta, miyagun ƙwayoyi suna contraindicated a cikin allergies.

Daga cikin tasirin sakamako, ciwon kai da ciwon tsoka, raunin fata, da kara sautin tsoka sun fi yawa. Lokacin yin gwajin sarrafawa, matakan transaminases wani lokacin yakan tashi. A cikin marasa lafiya da ke shan magani da kuma gunaguni na raɗaɗin tsoka, wajibi ne a bincika matakin CPK (tunda lalatawar tsoka ko rhabdomyolysis zai yiwu).

A cikin umarnin don amfani da Rosuvastatin, sashe na alamomi na musamman da kuma hulɗa da miyagun ƙwayoyi waɗanda dole ne a yi la’akari da su kafin fara bayanin an bayyana su dalla-dalla.

Analogs da generics na Rosuvastatin

A halin yanzu, adadi mai yawa na analogues na rosuvastatin asali sun bayyana a farashi daban-daban, tare da bita daban-daban, amma tare da umarni ɗaya don amfani. Kuma wannan babu makawa yana nuna ingancin ingancin kayan da ake amfani dasu. Za'a iya siyan asali na "Crestor" a "farashin cizo": ana iya siyan mafi ƙarancin 0.005 g No. 28 za'a iya siyan 1299 rubles, kuma Allunan ana iya samun adadin 40% a daidai adadin ana siyar dasu daga 4475 rubles. Amma jagora wani kunshin ne na Allunan 126 na "Crestor" 10 MG kowane, farashinsa shine 8920 rubles. A wannan yanayin, farashin kwamfutar hannu ɗaya shine rubles 70.

Analogs masu yawa suna da rahusa kamar haka: ana iya siyan allunan rosuvastatin kwalaji daga Canonfarm Production tare da masana'anta a cikin Schelkovo, Yankin Moscow, za'a iya sayan daga 355 rubles. (10 mg No. 28). Samun alamar kirki mai kyau "Mertenil" daga kamfanin "Gedeon Richter" (Hungary) a kashi 20 na MG, wanda shine matsakaici, zaka iya siyan 800 800 rubles A'a 30, kuma kwantena ya isa har tsawon wata guda.

Mafi arha a farashin gaske, rosuvastatin (ba tare da la'akari da adadin Allunan da sashi ba) ana ba da ta FP Obolenskoye - 244 rubles a kowane fakitin 10 MG na 28. A takaice dai, farashin kwamfutar hannu guda ɗaya na mai ƙarancin kuɗi shine 8.7 rubles, wanda yake mai rahusa allunan asali fiye da sau 8.

A ƙarshe, Ina so in sake jawo hankali ga tsananin ƙaddamar da haƙuri wanda ke ɗaukar kowane irin abincin sittin, rage rage cin abincin mai. Hakanan yana da kyau a rasa nauyi, kawar da munanan halaye, kuma yayin shan magungunan - a kai a kai suna lura da matakin cututtukan hepatic da kuma kimanta tasirin tasirin mai yalwar cutar.

Formaddamar da tsari da abun da ke ciki

An samar da miyagun ƙwayoyi a cikin nau'i na allunan mai rufi tare da membrane fim: biconvex, zagaye, ruwan hoda a launi, ainihin akan giciye shine kusan fari ko fari (kwafi 10.) A cikin fakiti mai laushi, a cikin kwali na kwali 3 ko fakitoci 6, guda biyu. marufin furen bakin, a cikin fakiti 2 ko 4, fakitoci 30 a cikin kunshin firinji, a cikin fakitin kwali 2, 3 ko 4, fakiti 20 ko 90. a cikin kwalbar polymer / kwalban filastik, a cikin kwali na kwali 1 / gilashi, kowane fakitin ya ƙunshi umarnin don amfani da Rose Vastatin-SZ).

Kwamfutar hannu 1 ya ƙunshi:

abu mai aiki: rosuvastatin (a cikin nau'i na alli rosuvastatin) - 5, 10, 20 ko 40 mg,
componentsarin abubuwan da aka haɗa: alli hydrogen phosphate dihydrate, lactose monohydrate (sukari madara), povidone (ƙananan ƙwayoyin polyvinylpyrrolidone low), sodium stearyl fumarate, ƙwayoyin sitiriyo sitiri (primrose), celclostse microcrystalline, cellolose silicon dioxide (aerosil),
rufin fim: Opadry II macrogol (polyethylene glycol) 3350, polyvinyl barasa, partially hydrolyzed, titanium dioxide (E171), talc, soy lecithin (E322), varnish na aluminika dangane da fenti azorubine, varnish na aluminika bisa dye indigo carmin, allon allon na tushen dye kararrawa (Ponceau 4R).

Side effects

Yayin jiyya tare da kwayoyin, sakamako masu illa suna da laushi, sau da yawa yakan tafi da kansu. Sakamakon mummunan sakamako na miyagun ƙwayoyi Rosuvastatin sune:

ciwon sukari mellitus
ciwon kai, farin ciki, rashi ƙwaƙwalwar ajiya, neuropathy na gefe,
maƙarƙashiya, ciwon zuciya, tashin zuciya, ciwon ciki, hepatitis, zawo,
pruritus, urticaria, kurji, Stevens-Johnson ciwo,
myalgia, rhabdomyolysis, myopathy, myositis, arthralgia,
cutar asthenic
kumburi kumburi
rigakafin mahaifa
furotin, hematuria,
increasedara yawan jigilar hepatic, glucose, bilirubin (jaundice) maida hankali,
thrombocytopenia
tari, kasawar numfashi,
gynecomastia
na gefe harshe,
ciki, rashin bacci, baccin dare,
take hakkin glandar thyroid, aikin jima'i, tsarin zuciya da jijiyoyin jini,
ƙara haɓakar haemoglobin.

Yawan abin sama da ya kamata

Idan kun ɗauki allurai na yau da kullun na rosuvastatin a lokaci guda, kantin magani ba zai canza ba. Bayyanar cututtuka na yiwuwar yawan ƙarin yawan ƙwayoyin cuta yana inganta sakamako masu illa. Babu maganin rigakafin maye. An ba da shawarar zuwa kurkura cikin ciki, rubutaccen magani tare da tallafin hanta da sauran gabobin mahimmanci. Hemodilais baya nuna tasiri.

Rosuvastatin analogs

Kuna iya maye gurbin allunan rosuvastatin tare da shirye-shiryen waɗanda ke ɗauke da abu ɗaya ko daidai mai aiki. Hanyoyin magungunan sun hada da:

Crestor - Allunan rage ƙananan ƙwayoyi tare da kayan aiki iri ɗaya,
Rosart - Allunan tare da irin wannan abun don maganin cututtukan zuciya,
Roxer - allunan daga rukunan gumakan,
Tevastor - Allunan akan dogayen aiki guda, rage cholesterol.

Rosuvastatin da Atorvastatin - menene bambanci

Analogue na Rosuvastatin - Atorvastatin, an haɗa shi a cikin rukuni na rukuni guda na magunguna kuma ana samun su a cikin kwamfutar hannu tare da kayan mai rage kiba. Ba kamar kayan da ake tambaya ba, atorvastatin ya fi narkewa a fats, kuma ba cikin plasma jini ko wasu ruwaye ba, sabili da haka yana shafar tsarin kwakwalwa, kuma ba kan sel hanta ba (hepatocytes).

Magungunan Rosuvastatin yana da 10% mafi inganci fiye da Atorvastatin, wanda ya ba da damar amfani dashi a cikin lura da marasa lafiya da keɓaɓɓen cholesterol. Hakanan, wakili a karkashin la'akari yana da inganci sosai game da tosheccen abubuwa a cikin hanta kuma yana da tasirin sakamako na warkewa. Sakamakon sakamako na magunguna iri ɗaya ne, don haka zaɓin magani ya ta'allaka ne da likita.

Pharmacokinetics

Matsakaicin taro na rosuvastatin (C_max) cikin plasma jini ana lura da sa'o'i 5 bayan maganin baka. Cikakken bioavailability na miyagun ƙwayoyi shine kusan 20%, ƙarar rarraba (V_d) - kimanin lita 134. Rosuvastatin yana ɗaure wa furotin plasma, galibi tare da albumin, kusan kashi 90%. Bayyanar tsari (AUC) na abu mai aiki yana ƙaruwa gwargwadon kashi. Tare da yin amfani da yau da kullun, halayen magunguna ba su canzawa.

Rosuvastatin yana metabolized mafi yawa ta hanta - babban shafin samar da cholesterol da kuma canji na rayuwa na LDL-C.An metabolized zuwa ƙaramin digiri (kusan 10%), abu mai aiki shine madaidaicin abin da ba zai canza ma'anar rayuwa ba ta hanyar enzymes na tsarin cytochrome P450. Babban isoenzyme da ke da alhakin metabolism na abu shine isoenzyme CYP2C9, isoenzymes CYP2C19, CYP3A4 da CYP2D6 ba su da hannu a cikin metabolism. Babban tushen metabolites na rosuvastatin sune lactone metabolites da N-desmethylrosuvastatin. Latterarshen kusan 50% ba shi da aiki fiye da rosuvastatin. Lactone metabolites suna dauke da magunguna marasa amfani. Fiye da 90% na aikin magungunan ƙwaƙwalwar ƙwaƙwalwa a cikin ragewa H22-CoA reductase an bayar dashi ta rosuvastatin kuma 10% ta metabolites.

Kusan 90% na kashi na rosuvastatin an keɓance ta cikin hanjin ta hanyar da ba ta canzawa (gami da sha da kayan da ba a sansu ba), ragowar ne ya toshe ta. Rabin rayuwar (T_1/2) daga plasma kamar awanni 19 ne kuma baya canzawa tare da kara kashi. Geometric ma'anar bayanan plasma shine kusan 50 l / h (babban adadin bambancin 21.7%). Mai samar da membrane na cholesterol, wanda ke taka muhimmiyar rawa a cikin aikin kawar da wannan kayan hepatic, ya shiga cikin haɓaka hepatic na rosuvastatin.

Sigogi na pharmacokinetic na rosuvastatin ba su da 'yanci da jinsi da shekarun mai haƙuri.

Rosuvastatin, kamar sauran masu hana HMG-CoA reductase, ɗaure zuwa sunadaran jigilar kayayyaki, irin su BCRP (jigilar mai amfani da isasshen ruwan sama) da OATP1B1 (polypeptide na jigilar tsofaffin kwayoyin halittar da ke tattare da kama gumakan da ƙwayoyin hanta). Masu ɗaukar kwayoyin genotypes ABCG2 (BCRP) s.421AA da SLC01B1 (OATP1B1) s.521CC sun nuna karuwa a cikin AUC na rosuvastatin ta hanyar 2.4 da 1.6, bi da bi, idan aka kwatanta da masu ɗaukar kwayoyin genotypes ABCG2 c.421CC da SLCO1B1 c.521TT.

Rosuvastatin-SZ, umarnin don amfani: hanyar da sashi

Rosuvastatin-SZ ana ɗauka ta bakake. Allunan, bawai murƙushewa da taunawa ba, ya kamata a hadiye su gaba ɗaya, a wanke da ruwa.

Ana iya amfani da wakili mai saurin rage zafin nama ba tare da la'akari da yawan abinci ba a kowane lokaci na rana.

Kafin fara karatun, mai haƙuri ya kamata ya canza zuwa daidaitaccen abincin tare da ƙananan abun ciki na cholesterol sannan kuma bi shi a duk tsawon lokacin maganin. An zaɓi kashi ɗaya akayi daban-daban, yin la'akari da martani na warkewa ga gudanarwar miyagun ƙwayoyi da makasudin magani, kazalika da dacewa da shawarwari na yanzu akan matakan maganin rage ƙwayar cutar.

Ga marasa lafiya waɗanda ba a ba su a baya tare da statins, ko kuma waɗanda suka ɗauki sauran HMG-CoA reductase inhibitors kafin fara karatun, shawarar farko na Rosuvastatin-SZ shine 5/10 mg sau ɗaya a rana. An kafa kashi na farko, an tsara shi ta hanyar tattarawar mutum a cikin cholesterol kuma yin la'akari da yiwuwar rikicewar cututtukan zuciya, da kuma barazanar yiwuwar halayen da ba a so. Idan ya cancanta, ƙara kashi bayan makonni 4.

Sakamakon yiwuwar faruwar sakamako a yayin gudanar da 40 MG / rana, idan aka kwatanta da ƙananan allurai na yau da kullun, yana yiwuwa a ƙara kashi zuwa 40 MG / rana (bayan ƙarin ƙarin ƙimar da aka bayar da shawarar farko don makonni 4) kawai idan akwai mummunar cutar. digiri na hypercholesterolemia da babban haɗarin ci gaba da rikitarwa na zuciya. Har zuwa 40 MG / rana ana ba da umarnin musamman ga marasa lafiya tare da familial hypercholesterolemia, waɗanda ba su sami damar cimma sakamakon magani da ake so tare da 20 mg / rana ba, kuma wanene zai kasance a ƙarƙashin kulawa mai ƙoshin lafiya. Musamman saka idanu na likita a hankali ana buƙatar marasa lafiya da suke karɓar kashi 40 na yau da kullun na Rosuvastatin-SZ.

Marasa lafiya waɗanda ba su taɓa tuntuɓar ƙwararrun likitoci ba a ba da shawarar su ɗauki Allunan Rosuvastatin-SZ 40 mg.

Makonni biyu na 2 bayan farawa ta hanyar jiyya da / ko tare da karuwa a cikin kashi, kula da ƙwayar lipid ya kamata a aiwatar kuma, idan ya cancanta, ya kamata a daidaita sashi.

Masu ɗaukar jigilar kwayoyin halittar c.421AA ko s.521CC ba a ba da shawarar yin amfani da rosuvastatin-SZ a allurai da suka wuce 20 MG sau ɗaya a rana.

A yayin aiwatar da nazarin kantin magunguna na rosuvastatin a cikin marassa lafiya mallakar kabilu daban-daban, lokacin da Jafananci da Sinawa suka sha maganin, an bayyana karuwa a tsarin maida hankali na rosuvastatin. Dole ne a la'akari da wannan sabon abu yayin la'akari da wakili na rage yawan lipid ga wakilan tsere na Mongoloid. Don wannan rukuni na marasa lafiya tare da magani a allurai na 10 da 20 MG, daya ya kamata ya fara da shan 5 MG / rana, allunan a cikin sashi na 40 MG suna contraindicated.

Marasa lafiya da ke da tabbatuwa ga ci gaban myopathy Rosuvastatin-SZ ana bada shawara don ɗaukar kashi na farko na 5 MG.

Tasiri a kan ikon tuka motoci da abubuwa masu rikitarwa

Ba a gudanar da nazarin don yin nazarin yiwuwar Rosuvastatin-SZ akan ikon tuki motocin ba da kuma amfani da tsararrun hanyoyin aiki. Lokacin yin ayyukan da ke da haɗari, marasa lafiya suna buƙatar yin hankali, saboda mayya na iya faruwa yayin jiyya.

Haihuwa da lactation

Rosuvastatin-SZ yana contraindicated a cikin ciki da lactation. Matan da suka isa haihuwa ba dole ne su yi amfani da abin da ake iya maye gurbinsu ba.

Tun da cholesterol da cholesterol kayayyakin biosynthesis suna da matukar muhimmanci ga haɓakar tayi, yuwuwar haɗarin rage HMG-CoA rageccase ya fi fa'idodin shan Rosuvastatin-SZ a cikin mata masu juna biyu. Idan batun ciki yayin magani tare da miyagun ƙwayoyi, ya kamata a dakatar da tsarinta nan da nan.

Babu bayanai game da rarraba rosuvastatin tare da madara, sabili da haka, yayin lactation, ya zama dole a daina shan Rosuvastatin-SZ.

Tare da nakasa aiki na koda

A cikin marasa lafiya da gazawar sassaucin matsakaici ko matsakaici, babu wani canji mai mahimmanci a cikin matakin plasma na rosuvastatin ko N-desmethylrosezuvastatin. A cikin gazawar ƙoshin yara, matakin rosuvastatin a cikin plasma jini shine sau 3, kuma N-desmethylrosuvastatin ya ninka sau 9 sama da na masu sa kai lafiya. Yawan plasma na rosuvastatin a cikin marasa lafiyar da ke fuskantar hemodialysis ya kusan 50% sama da na masu sa kai na lafiya.

Yarda da Rosuvastatin-SZ an contraindicated a gaban mai girma raunin nakalwa (creatinine Cl da ke ƙasa 30 ml / min).

Ga marasa lafiya da ke cikin matsakaici marasa ƙarfi na ƙwayoyin ƙwayoyin cuta (Cl creatinine 30-60 ml / min), amfani da rosuvastatin-SZ a cikin kashi 40 MG ya saba, kuma a kashi 5, 10 da 20 mg ya kamata a yi amfani da shi tare da taka tsantsan.

Ya kamata a kula da marasa lafiya tare da raunin ɗan yara (creatinine Cl sama da 60 ml / min) tare da kashi 40 na MG tare da taka tsantsan, sa ido kan aikin koda. Lokacin amfani da miyagun ƙwayoyi a cikin marasa lafiya tare da matsakaici na aiki mai sassaucin aiki, kashi na farko ya zama 5 MG.

Tare da aikin hanta mai rauni

A gaban raunin hanta daga maki 7 da ƙasa a kan sikelin Yara-Pugh, karuwa a cikin T_1/2 ba a gano rosuvastatin ba, karuwa a cikin T an rubuta shi a cikin marasa lafiya biyu tare da maki 8 da 9_1/2 ba kasa da sau 2. Babu wani gogewa game da amfani da Rosuvastatin-SZ a cikin marasa lafiya waɗanda yanayinsu ya ƙimanta sama da 9 akan sikelin Yara-Pugh.

Jiyya tare da miyagun ƙwayoyi yana cikin contraindicated a cikin marasa lafiya da cututtukan hanta a cikin yanayin fashewa, ciki har da tare da ci gaba da ƙaruwa a cikin aikin transaminase da kowane karuwa a cikin aikin transaminase, fiye da sau 3 mafi girma fiye da VGN. Tare da taka tsantsan, ana ba da shawarar yin amfani da Rosuvastatin-SZ a cikin marasa lafiya tare da tarihin lalacewar hanta. Tabbatar da alamun alamun aikin hanta ya zama dole kafin magani da watanni 3 bayan fara karatun.

Ra'ayoyi game da Rosuvastatin-SZ

Dangane da sake dubawa, Rosuvastatin-C3 magani ne mai mahimmanci wanda yake amfani da shi don magance hypercholesterolemia, rage jinkirin ci gaba da atherosclerosis da hana rikicewar cututtukan zuciya. Sakamakon farko na magani ana lura da yawancin marasa lafiya bayan sati daya na gudanarwa, kuma mafi girman tasirin shine watan 1 bayan fara karatun. Dangane da sake dubawa, saboda aikin miyagun ƙwayoyi, matakin cholesterol a cikin jini yana raguwa, saukar karfin jini, yanayin gaba ɗaya yana inganta, gajeriyar numfashi lokacin tafiya yana raguwa. A lokacin jiyya, a wasu yanayi, ƙara yawan nauyin jiki yana raguwa saboda haɗuwa da miyagun ƙwayoyi tare da rage ƙarancin cholesterol.

Rashin daidaituwa na Rosuvastatin-SZ sun haɗa da adadi mai yawa na contraindications da halayen m. A cikin wasu sake dubawa, marasa lafiya suna nuna rashin gamsuwarsu da farashin magungunan, saboda ana ɗaukar shi tsawon lokaci, farashin magani yana buƙatar cikakken aikin magani, a ra'ayinsu, ya yi yawa sosai.