Insulin kamar yadda biphasicum ya dauki nauyin jikin shi

Haɗin insulin gabaɗaya, analog na insulin ɗan adam. Dakatar da rashin lafiyan wanda ya kunshi insulin na narkewa (30%) da lu'ulu'u na insulin aspart protamine (70%). Insulin kamar yadda aka samu ta hanyar fasahar DNA ta sake yin amfani da nau'in Saccharomyces cerevisiae, a cikin kwayoyin insulin, amino acid proline a matsayin B28 an maye gurbinsu da aspartic acid.

Pharmacology

Biphasic insulin aspart yayi hulɗa tare da takamaiman masu karɓar ƙwayar cytoplasmic ƙwayoyin sel kuma yana samar da hadaddun insulin-receptor wanda ke motsa ayyukan cikin ciki, gami da kira na enzymes masu yawa (hexokinase, pyruvate kinase, glycogen synthetase). Rage yawan haɗuwa da glucose a cikin jini shine saboda karuwa a cikin jijiyoyin zuciya, karuwar haɓaka ta tsoka da ƙwayar adipose, da raguwa a cikin yawan samar da glucose a cikin hanta. Yana da aiki iri ɗaya kamar na insulin ɗan adam a cikin molar daidai. Canji na amino acid proline a matsayin B28 tare da aspartic acid yana rage sha'awar kwayoyin halitta don samar da hexamers a cikin narkewa mai narkewa na miyagun ƙwayoyi, wanda aka lura a cikin insulin ɗan adam mai narkewa. Dangane da wannan, ana samun insulin aspart daga kitse mai ƙarewa da sauri fiye da insulin mai narkewa wanda yake cikin insulin na ɗan adam. Insulin na protamine ana amfani dashi tsawon lokaci. Bayan sc gudanarwa, sakamakon yana tasowa bayan minti 10-20, matsakaicin sakamako bayan awanni 1-4, tsawon lokacin aiki ya kai awowi 24 (ya danganta da sashi, wurin gudanarwa, kwararar jini, yawan zafin jiki da matakin motsa jiki).

Lokacin s / zuwa kashi na 0.2 U / kg nauyin jiki T_max - minti 60 Haɗin zuwa sunadarai na jini low ne (0-9%). Yawan maida hankali insulin ya koma asalin bayan 15-18-18.

Haihuwa da lactation

Amfani da shi yayin daukar ciki yana yiwuwa idan tsammanin sakamako na aikin likita ya wuce haɗarin haɗari ga tayin (ba a gudanar da nazarin ingantaccen nazari ba). Ba'a sani ba shin insulin aspart biphasic zai iya yin tasiri cikin tayi yayin amfani dashi lokacin daukar ciki da kuma ko yana shafar damar haihuwa.

A cikin lokacin yiwuwar farawar ciki kuma a duk tsawon lokacinsa, Wajibi ne a lura da yanayin marasa lafiya da masu ciwon sukari da kuma lura da matakin glucose a cikin jini. Bukatar insulin, a matsayin mai mulkin, yana raguwa a cikin farkon farkon kuma a hankali yana ƙaruwa a cikin watanni na biyu da na uku na ciki.

Yayin haihuwar yara kuma nan da nan bayan su, buƙatar insulin na iya raguwa sosai, amma da sauri ya koma matakin da ya gabata kafin samun juna biyu.

Ba a san ko miyagun ƙwayoyi sun shiga cikin madara ba. A lokacin shayarwa, za'a iya samun bukatar gyara kashi.

Insulin kamar yadda yake guda biyu: Tasirin sakamako

Kuskurewar cuta da nakuda (a farkon jiyya), halayen rashin lafiyan gida (hyperemia, kumburi, ƙoshin fata a wurin allura), haɓaka halayen ƙwayar cuta (fatar fata, ƙaiƙayi, ƙoshin ɗumi, aiki na hanji, wahalar numfashi, wahala tachycardia, rage karfin jini, angioedema edema), lipodystrophy a wurin allurar.

Haɗa kai

Abubuwan insulin kashi-kashi kashi biyu ne cikin harhada magunguna da jituwa tare da maganin sauran kwayoyi. Tasirin hypoglycemic yana haɓaka ta magungunan hypoglycemic na baki, sulfanilamides, MAO inhibitors (ciki har da furazolidone, procarbazine, selegiline), inhibitors na carbonic, inhibitors na ACE, steroids anabolic (gami da stanozolol, oxandrolone, metroprotinol da tetroprotin) , rashin biyayya, fibrates, fluoxetine, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, pyridoxine, quinidine, quinine, chloroquine, ethanol da ethanol dauke da kwayoyi. Hypoglycemic effects na sosai glucocorticoids, glucagon, girma hormone, thyroid hormones, estrogens, progestogens (misali baka hana), thiazide diuretics, CCB, heparin, sulfinpyrazone, sympathomimetics (kamar epinephrine, salbutamol, terbutaline), isoniazid, phenothiazine Kalam, danazol, tricyclics, diazoxide, morphine, nicotine, phenytoin.

Beta-blockers, clonidine, gishiri na lithium, reserpine, salicylates, pentamidine - zasu iya haɓakawa da raunana tasirin hypoglycemic na insulin.

Biphasic insulin aspart: Sashi da gudanarwa

P / c, kai tsaye kafin abinci, idan ya cancanta - nan da nan bayan cin abinci. Za'ayi amfani da allurar a cikin cinya ko bangon ciki, ko a kafada ko a gindi. Wajibi ne a canza wurin allurar a cikin yankin na jiki (don hana haɓakar lipodystrophy). Zazzabi na insulin da ke cikin yakamata ya zama zazzabi a dakin.

Yawan insulin asf na biphsic likita ne ya ƙaddara shi daban-daban a kowane yanayi, gwargwadon yawan glucose a cikin jini. A matsakaici, kashi na yau da kullun shine 0.5-1 raka'a / kg nauyin jiki. Tare da juriya na insulin (alal misali, cikin kiba), ana buƙatar ƙara yawan buƙatar insulin yau da kullun, kuma a cikin marasa lafiya da keɓaɓɓen insulin insulin insulin.

Kariya da aminci

Kada ayi amfani da insulin kashi biyu a cikin iv. Rashin isasshen kashi ko dakatar da magani (musamman tare da nau'in ciwon sukari na 1) na iya haifar da haɓakar haɓakar hyperglycemia ko ketoacidosis na ciwon sukari. A matsayinka na mai mulki, hyperglycemia yana nuna kanta a hankali a kan sa'o'i da yawa ko kwanaki (alamun cututtukan hyperglycemia: tashin zuciya, amai, nutsuwa, jan jiki da bushewar fata, bushewar baki, ƙara yawan fitsari, ƙishirwa da asarar ci, bayyanar ƙamshin acetone a cikin iska), kuma ba tare da magani da ya dace ba na iya haifar da mutuwa.

Bayan ramawa game da metabolism na metabolism, alal misali, a lokacin maganin insulin mai zurfi, marasa lafiya na iya fuskantar alamu na alamu na abubuwan rashin lafiya na farko, wanda ya kamata a sanar da marasa lafiya game da. A cikin marasa lafiya da masu ciwon sukari tare da ingantaccen kulawa na rayuwa, ƙarshen rikicewar ciwon sukari ya inganta daga baya kuma ya ci gaba da hankali. A wannan batun, an ba da shawarar aiwatar da ayyukan da aka tsara don inganta sarrafa metabolism, gami da saka idanu kan matakin glucose a cikin jini.

Yakamata ayi amfani da insulin kashi biyu a cikin haɗin kai tsaye tare da ɗaukar abinci. Wajibi ne a la’akari da babban adadin farawar tasirin a cikin kulawa da marasa lafiya da cututtukan da suka dace ko shan magunguna waɗanda ke rage yawan shan abinci. A gaban cututtukan da ke tattare da cuta, musamman ma yanayin da ke tattare da cutar, buƙatar insulin yana ƙaruwa. Alarancin haya da / ko aikin hanta na iya haifar da raguwa cikin bukatun insulin. Ski abinci ko motsa jiki mara tsari na iya haifar da ci gaban haɓakar ƙwanƙwasa.

Tare da haɓakar hypoglycemia ko hyperglycemia, raguwa game da hankalin hankali da saurin amsawa mai yiwuwa ne, wanda zai iya zama haɗari yayin tuki mota ko aiki tare da injuna da injuna. Ya kamata a shawarci marassa lafiya su dauki matakan hana ci gaban hauhawar jini da hauhawar jini. Wannan yana da mahimmanci musamman ga marasa lafiya da basu da cikakkun alamu na abubuwan ci gaban haila ko kuma fama da yawan cututtukan cututtukan zuciya.

Sunayen Kasuwanci

NovoMix 30 Penfill: dakatarwa don gudanar da aikin karkashin kasa na 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 30 FlexPen: dakatarwa don gudanar da aikin karkashin kasa na 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 50 FlexPen: dakatarwa don gudanar da aikin karkashin kasa na 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 70 FlexPen: dakatarwa don gudanar da aikin karkashin kasa na 100 PIECES / ml, Novo Nordisk (Denmark)

Aikin magunguna

Yana hulɗa tare da takamaiman masu karɓa na ƙwayoyin cytoplasmic ƙwayoyin sel kuma yana samar da hadaddun insulin-receptor wanda ke motsa ayyukan cikin ciki, gami da kira na enzymes masu yawa (hexokinase, pyruvate kinase, glycogen synthetase). Rage yawan haɗuwa da glucose a cikin jini shine saboda karuwa a cikin jijiyoyin zuciya, karuwar haɓaka ta tsoka da ƙwayar adipose, da raguwa a cikin yawan samar da glucose a cikin hanta. Yana da aiki iri ɗaya kamar na insulin ɗan adam a cikin molar daidai. Canji na amino acid proline a matsayin B28 tare da aspartic acid yana rage sha'awar kwayoyin halitta don samar da hexamers a cikin narkewa mai narkewa na miyagun ƙwayoyi, wanda aka lura a cikin insulin ɗan adam mai narkewa. Dangane da wannan, ana samun insulin aspart daga kitse mai ƙarewa da sauri fiye da insulin mai narkewa wanda yake cikin insulin na ɗan adam. Insulin na protamine ana amfani dashi tsawon lokaci. Bayan sc gwamnati, sakamakon yana haɓakawa a cikin 10-20 min, matsakaicin sakamako a cikin h h, tsawon lokacin aiki yana zuwa 24 h (ya dogara da kashi, wurin gudanarwa, yawan zubar jini, zafin jiki, da matakin motsa jiki). Lokacin s / zuwa kashi 0.2 U / kg nauyin jikin Tmax - minti 60 Haɗin zuwa sunadarai na jini low ne (0-9%). Yawan maida hankali insulin ya koma asalin bayan 15-18-18.

Halin abubuwan da ke cikin Insulin ana biphusic

Haɗin insulin gabaɗaya, analog na insulin ɗan adam. Dakatar da rashin lafiyan wanda ya kunshi insulin na narkewa (30%) da lu'ulu'u na insulin aspart protamine (70%). An samo shi ta hanyar insulin ta hanyar fasahar DNA ta sake amfani da iri Saccharomyces cerevisiae, a cikin tsarin kwayoyin insulin, ana samar da amino acid a matsayi B28 da aspartic acid.

Sakamakon sakamako na abubuwa shine Insulin asph biphasic

Kuskurewar cuta da nakuda (a farkon jiyya), halayen rashin lafiyan gida (hyperemia, kumburi, ƙoshin fata a wurin allura), haɓaka halayen ƙwayar cuta (fatar fata, ƙaiƙayi, ƙoshin ɗumi, aiki na hanji, wahalar numfashi, wahala tachycardia, rage karfin jini, angioedema edema), lipodystrophy a wurin allurar.

Yawan abin sama da ya kamata

Kwayar cutar hypoglycemia - "sanyi" gumi, pallor na fata, juyayi, rawar jiki, tashin hankali, gajiya sabon abu, rauni, disorientation, rashin damuwa, rashi, tsananin yunwa, rauni na gani na lokaci, ciwon kai, tashin zuciya, tachycardia, cramps, neurological cuta coma.

Jiyya: mai haƙuri na iya dakatar da ƙaramar ƙimar jini ta hanyar ɗaukar glucose, sukari ko abinci mai-carbohydrate. A cikin lokuta masu tsanani - in / a cikin 40% dextrose bayani, in / m, s / c - glucagon. Bayan ya dawo da hankali, ana ba da shawarar mai haƙuri ya ci abinci mai arzikin carbohydrate don hana sake haɓakar ƙwanƙwasa jini.

Kariya abubuwa abubuwa insulin kamar gudawa

Ba za ku iya shiga iv ba. Rashin isasshen kashi ko dakatar da magani (musamman tare da nau'in ciwon sukari na 1) na iya haifar da haɓakar haɓakar hyperglycemia ko ketoacidosis na ciwon sukari. A matsayinka na mai mulki, hyperglycemia yana nuna kanta a hankali a kan sa'o'i da yawa ko kwanaki (alamun cututtukan hyperglycemia: tashin zuciya, amai, nutsuwa, jan jiki da bushewar fata, bushewar baki, ƙara yawan fitsari, ƙishirwa da asarar ci, bayyanar ƙamshin acetone a cikin iska), kuma ba tare da magani da ya dace ba na iya haifar da mutuwa.

Bayan ramawa game da metabolism na metabolism, alal misali, a lokacin maganin insulin mai zurfi, marasa lafiya na iya fuskantar alamu na alamu na abubuwan rashin lafiya na farko, wanda ya kamata a sanar da marasa lafiya game da. A cikin marasa lafiya da masu ciwon sukari tare da ingantaccen kulawa na rayuwa, ƙarshen rikicewar ciwon sukari ya inganta daga baya kuma ya ci gaba da hankali. A wannan batun, an ba da shawarar aiwatar da ayyukan da aka tsara don inganta sarrafa metabolism, gami da saka idanu kan matakin glucose a cikin jini.

Ya kamata a yi amfani da miyagun ƙwayoyi a cikin haɗin kai tsaye tare da ɗaukar abinci. Wajibi ne a la’akari da babban saurin tashin farko na tasirin sakamako a cikin lura da marasa lafiya da cututtukan da ke haɗa kai ko shan magunguna waɗanda ke rage jinkirin abinci. A gaban cututtukan da ke tattare da cuta, musamman ma yanayin da ke tattare da cutar, buƙatar insulin yana ƙaruwa. Alarancin haya da / ko aikin hanta na iya haifar da raguwa cikin bukatun insulin. Ski abinci ko motsa jiki mara tsari na iya haifar da ci gaban haɓakar ƙwanƙwasa.

Canjin haƙuri ga sabon nau'in insulin ko shirya insulin na wani samarwa dole ne a aiwatar dashi karkashin kulawar likita, ana buƙatar daidaita sashi. Idan ya cancanta, ana iya yin gyare-gyare gwargwadon rigakafin farko na miyagun ƙwayoyi ko a cikin makonni na farko ko watanni na farko na magani. Canji a kashi na iya buƙata tare da canji a abinci kuma tare da haɓaka aiki na jiki. Yi motsa jiki nan da nan bayan cin abinci na iya ƙara yawan haɗarin kumburi.

Tare da haɓakar hypoglycemia ko hyperglycemia, raguwa game da hankalin hankali da saurin amsawa mai yiwuwa ne, wanda zai iya zama haɗari yayin tuki mota ko aiki tare da injuna da injuna. Ya kamata a shawarci marassa lafiya su dauki matakan hana ci gaban hauhawar jini da hauhawar jini. Wannan yana da mahimmanci musamman ga marasa lafiya da basu da cikakkun alamu na abubuwan ci gaban haila ko kuma fama da yawan cututtukan cututtukan zuciya.

Ka'idojin aiki

Wannan maganin yana ɗaure wa masu karɓar insulin a cikin tso adi nama da tsokoki tsokoki. Matsakaicin glucose a cikin jini yana raguwa saboda gaskiyar cewa kyallen takarda na iya yin amfani da glucose sosai, hakanan, ya fi kyau shiga cikin sel, yayin da adadin samuwar ta a cikin hanta, akasin haka, yana rage gudu. Tsarin tsintsiyar mai a jiki yana karawa da haɓaka tsarin ayyukan furotin.

Ayyukan miyagun ƙwayoyi yana farawa a cikin mintuna 10 zuwa 20, kuma an lura da matsakaiciyar kulawa a cikin jini bayan sa'o'i 1-3 (wannan shine sau 2 cikin sauri idan aka kwatanta da hormone na mutum). Ana siyar da wannan insulin na monocomponent a ƙarƙashin sunan cinikayyar NovoRapid (ban da shi, akwai kuma insulin kashi biyu, wanda ya bambanta da tsarin sa).

Inshosic insulin

Biphasic insulin aspart yana da manufa iri ɗaya na tasirin magunguna akan jiki. Bambancin shine ya ƙunshi insulin gajeran aiki (a zahiri yana kwance) da kuma wani matsakaicin aiki (protamine-insulin aspart). Matsakaicin waɗannan insulins a cikin maganin kamar haka: 30% shine hormone mai sauri kuma 70% sigar zamani ce.

Sakamakon farko na miyagun ƙwayoyi yana farawa a zahiri kai tsaye bayan gudanarwa (a cikin minti 10), kuma kashi 70% na sauran maganin yana haifar da wadatar insulin a ƙarƙashin fata. Ana sakewa da hankali kuma yana aiki akan matsakaici har zuwa awanni 24.

Akwai kuma magani wanda insulin gajeran aiki (aspart) da kuma matsanancin motsa jiki na tsawon lokaci (degludec). Sunan kasuwancinta shine Ryzodeg. Don shigar da wannan kayan aiki, kamar kowane insulin da aka haɗa, zaku iya subcutaneously, lokaci-lokaci canza yankin don injections (don guje wa haɓakar lipodystrophy). Tsawon lokacin da miyagun ƙwayoyi a kashi na biyu ya kasance zuwa kwanaki 2 zuwa 3.

Idan mai haƙuri sau da yawa yana buƙatar allurar nau'ikan hormone, to watakila ya fi dacewa a gare shi ya yi amfani da insulin kashi biyu. Wannan yana rage adadin injections kuma yana taimakawa sosai don sarrafa glycemia. Amma endocrinologist kawai zai iya zaɓar ingantaccen magani dangane da sakamakon binciken da bayanan gwajin makasudi.

Abvantbuwan amfãni da rashin amfani

Insulin aspart (biphasic da lokaci guda) ya sha bamban da insulin na mutum. A wani takamaiman matsayi, amino acid proline an maye gurbinsu da aspartic acid (wanda kuma aka sani da aspartate). Wannan kawai yana inganta kaddarorin kwayoyin kuma baya cikin kowace hanya ta shafi kyakkyawan haƙuri, aiki da ƙarancin ƙwayoyin cuta. Godiya ga wannan gyaran, wannan magani yana farawa da sauri fiye da yadda ake amfani da shi.

Daga raunin da ke tattare da miyagun ƙwayoyi tare da wannan nau'in insulin, yana yiwuwa a lura, dukda cewa ba kasafai ake faruwa ba, amma har yanzu akwai sakamako masu illa.

Zasu iya bayyana kansu ta hanyar:

• kumburi da jijiya a wurin allurar,
• lipodystrophy,
• fata tayi
• fata bushe,
• rashin lafiyan dauki.

Contraindications

Abubuwan hana rigakafi don amfani da miyagun ƙwayoyi sune rashin haƙuri na mutum, rashin lafiyan mutum da ƙarancin sukari na jini (hypoglycemia). Har ila yau, babu wani binciken da aka sarrafa dangane da amfanin wannan insulin a yayin daukar ciki da lokacin shayarwa. Gwajin dabbobi na preclinical sun nuna cewa a cikin allurai wadanda basu wuce abin da aka bada shawarar ba, magani yana shafar jikin mutum daidai da insulin na mutum.

A lokaci guda, lokacin da aka gudanar da aikin da aka wuce sau 4-8 a cikin dabbobi, an lura da ɓarna a farkon matakan, haɓakar ɓarna a cikin zuriya da matsaloli tare da haihuwar cikin matakai na gaba na ciki.

Ba'a san ko wannan maganin ya shiga cikin madarar nono ba, saboda haka ba a ba wa mata shawarar shayar da nono yayin jiyya. Idan mara lafiya yana buƙatar allurar insulin a lokacin daukar ciki, ana zaɓin maganin koyaushe daga kwatancen amfanin mahaifiyar da haɗarin tayi.

A matsayinka na mai mulki, a farkon lokacin daukar ciki, buƙatar insulin ya ragu sosai, kuma a cikin sati na biyu da na uku, ana iya sake buƙatar magani. Tare da ciwon sukari na gestational, wannan kayan aikin ba a amfani da shi ba. A kowane hali, ba kawai endocrinologist ba, amma kuma mai lura da likitan mata na likitan mata ya kamata ya ba da irin wannan magani ga mace mai juna biyu.

Wannan nau'in hormone a cikin mafi yawan lokuta ana haƙuri da haƙuri ga marasa lafiya, kuma sakamako masu illa daga amfani dashi da wuya.

Magunguna daban-daban tare da sunaye daban-daban na kasuwanci dangane da shi yana ba ku damar zaɓin mafi yawan mitar allura ga kowane mai haƙuri daban-daban. Lokacin yin magani tare da wannan magani, yana da mahimmanci a bi tsarin da likita ya ba da shawarar kuma kar a manta da abinci, motsa jiki da kuma salon rayuwa mai lafiya.

Fom ɗin saki

Dakatarwa d / da 100 IU / ml 3 ml No. 5

Bayanin da ke cikin shafin da kake kallo an ƙirƙiri shi don dalilai na kawai kuma ba ya inganta magungunan kai ta kowace fuska. Abun da aka shirya shine don sanin kwararrun masana kiwon lafiya tare da ƙarin bayani game da wasu magunguna, don haka ya ƙara yawan ƙwarewar su. Amfani da magani "Insulin kashi-kashi biyu" ba tare da gazawa na ba da shawara tare da gwani ba, kazalika da shawarwarinsa kan hanyar amfani da sashi na maganin da kuka zaɓa.

Insulin Ya raba kashi biyu

An shirya wannan shirin ne ta hanyar fasaha na musamman na DNA ta amfani da ƙwayar Saccharomyces cerevisiae, wanda aka maye gurbin amino acid da aspartic acid. Yin amfani da wannan magani na iya ramawa game da cutar sankarar bargo ta Mellitus (DM), rage yiwuwar takamaiman rikice-rikice na cutar, ko jinkirta abubuwan da ba makawa a cikin mutane tare da tarihin tarihi.

Abun ciki da nau'i na saki

Aiki abu na miyagun ƙwayoyi (insulin Aspart) wani abu ne wanda aka inganta ɗan adam na insulin na aikin ultrashort. Matsayin hypoglycemic yana samuwa azaman mai matakan biyu (mai narkewa insulin Aspart da lu'ulu'u protamine) don gudanarwa na cikin ciki da na ciki. Baya ga sashin aiki mai aiki, abun da ke cikin magungunan ya hada da kayan taimako. Duba tebur da ke ƙasa don ƙarin cikakkun bayanai.

Phosphate hydrogen foda na bushewa

Sodium hydroxide 2M

Hydrochloric acid 2M

Kayan magunguna

Abubuwan da ke aiki na miyagun ƙwayoyi suna hulɗa tare da takamaiman masu karɓa na ƙwayoyin cytoplasmic na sel, suna samar da nau'in hadaddun insulin masu karɓar insulin, wanda ke ƙarfafa haɗin enzymes masu mahimmanci. Sakamakon maganin yana faruwa ne saboda karuwar haɓaka glucose ta tsokoki, da raguwa a cikin aikin glycogenic na hanta.

Sauya amino acid a cikin matsayi na B28 tare da aspartic acid yana rage sha'awar kwayoyin don samar da hexamers a cikin narkewa na maganin, wanda aka lura a cikin yanayin halitta na hormone. Saboda wannan, ɗaukar Insulin Aspart daga kitse mai ƙananan nama yana faruwa da sauri fiye da mutum. Bayan allurar miyagun ƙwayoyi, tasirin hypoglycemia ya haɓaka a cikin mintina na 15-20, ya isa matsakaicinsa bayan sa'o'i 1-3, kuma bayan sa'o'i 5-6, ƙwaƙwalwar glucose ta koma matakin farko.

Alamu don amfani

An wajabta insulin Aspart don ciwon sukari mai yawa. A cikin nau'in ciwon sukari na 2, ana amfani da miyagun ƙwayoyi lokacin da mai haƙuri ya ɓace gaba ɗaya ko kuma ya rasa hankalin masu karɓar insulin zuwa ga wakilai na hypoglycemic na bakin yayin haɗuwa. Bugu da kari, samfurin da ake bayar da magani ya bada shawarar yin amfani da shi ta hanyar mutanen da, ban da cutar ta sankara (ciwon sukari), suna fuskantar yanayin abubuwan da suke haifar da cutar kansa.

Umarnin don amfani

Hanyar amfani da miyagun ƙwayoyi shine allurar subcutaneous. An hana allurar ciki An wajabta insus infusions sosai da wuya don alamomi na musamman. Ya kamata a gudanar da maganin a cikin bango na ciki, cinya ko gindi. Kuna iya amfani da kwatancin insulin na ɗan adam kafin abinci da kuma bayan abinci. Ana yin lissafin kashi na miyagun ƙwayoyi daban-daban ga kowane mara lafiya.

Tare da rauni na koda ko aikin hanta, buƙatar hormone yana raguwa, yayin da cututtukan cututtuka suna ƙaruwa, wanda ke buƙatar daidaita sashi na Insulin Aspart. Amfani da wannan magani yana da alaƙa da abinci, don haka ya cancanci ɗaukar girman abin da ya faru sakamakon marasa lafiya da ke shan magunguna waɗanda ke rage jinkirin shan abinci. Bayan ramawa game da metabolism na metabolism, marasa lafiya na iya fuskantar alamominsu na yau da kullun na hypoglycemia, suna buƙatar gudanar da hanzari don magance maganin glucose ko sukari a ciki.

Umarni na musamman

A cikin umarnin don amfani, an bayar da rahoton cewa isasshen magani ko katsewa na lura da ciwon sukari na iya haifar da hyperglycemia, ketoacidosis. Yin amfani da Insulin Aspart a wasu yanayi yana buƙatar haɓaka adadin injections na wakilai na hypoglycemic da aka yi amfani da su a baya. A yayin lura da ciwon sukari tare da wannan magani, yakamata a yi taka tsantsan yayin tuki motoci da shiga cikin wasu ayyuka masu haɗari waɗanda ke buƙatar karuwar hankali da saurin halayen psychomotor.

Hulɗa da ƙwayoyi

Insulin Aspart bai dace da sauran magunguna ba. Ayyukan miyagun ƙwayoyi suna haɓaka ta hanyar maganganu na maganin hypoglycemic na baki, masu hana MAO, masu hana ACE, carbon anhydrase, sulfonamides, steroids anabolic, tetracyclines, ethanol-kwayoyi masu dauke da kwayoyi. Magungunan hana haihuwa, maganin thiazide diuretics, heparin, maganin tricyclic antidepressants, morphine, sinadarin nicotine yana hana tasirin cutar kashi biyu. A ƙarƙashin rinjayar salicylates da reserpine, duka haɓakawa da rauni na aikin miyagun ƙwayoyi za a iya lura.

Side effects da yawan abin sama da ya kamata

Yin hukunci ta hanyar bita, a farkon jiyya tare da miyagun ƙwayoyi a cikin tambaya, cin zarafin shakatawa sau da yawa yakan faru, wanda mafi yawan ɓangare ne na ɗan lokaci. Zai yiwu ci gaban halayen halayen gida a cikin hanyar hyperemia, itching na fata a wurin allurar, fashin, kumburi. A cikin mafi yawan lokuta, ana lura da sakamako masu illa: angioedema, rage karfin jini, tachycardia, wahalar numfashi. A kan banbancin wucewa na insulin Aspart, waɗannan yanayin cututtukan na iya faruwa:

• hawan jini,
• katsewa
• cutar rashin daidaituwa
• m zafi neuropathy,
• karancin magana
• bacin rai
• ƙari na ciwon sukari,
• ƙara yin gumi.

Sharuɗɗan sayarwa da ajiya

Rayuwar rayuwar shiryayye shine watanni 30 daga ranar da aka ƙera shi. Dole ne a kiyaye Insulin Aspart daga haɗuwa da zafi zuwa haske. Adana ƙwayoyin halittar da aka gyara ta a zazzabi na 2-8ºC. Magunguna suna sayar da maganin ta musamman ta hanyar sayan magani.

Lokacin da amfani da canzawar yanayin sau biyu ba zai yiwu ba saboda rashin jituwa daga abubuwanda ya kunsa ko kuma bukatar magani mai rahusa, likitoci suna tsara magunguna masu kama da Insulin Aspart. A yau, ana ba da mabukaci babban zaɓi na wakilai na hypoglycemic, amma, zaɓi wannan ko waccan maganin, masana'antun daga Amurka, Japan, da Yammacin Turai sun fi son. A mafi yawan halayen, ana rubutasu hanyoyin analogues kamar haka:

• NovoRapid Flexpen,
• NovoLog,
• Rubutun NovoRapid.

Farashin insulin Aspart

Matsakaicin farashin magani a cikin kantin magunguna a Moscow kusan 1700-1800 p. da 3 ml na hypoglycemic bayani. Ganin cewa lura da ciwon sukari tare da insulin asali na asali yana buƙatar tsadar kuɗi mai mahimmanci, ba zai zama mafi girma ba don kulawa da albarkatu na musamman na Intanet, inda farashin maganin ya fi ƙasa da yadda aka fada a cikin kantin magunguna.

Olga, mai shekara 48. Na yi amfani da Insulin Aspart lokacin da na gano cewa kwayoyin hana daukar ciki suna daina aiki. Kullum maganin yana maganin likita. Dangane da shawarwarin da aka karɓa, na gabatar da rukunin 5 na bayani kafin kowane abinci. Godiya ga maganin, na sami damar daidaita matakan glucose cikin dan kankanen lokaci.

Andrey, shekaru 50. Domin shekaru 3 na sha wahala daga ciwon sukari mai cike da rashi. Kwayoyin, rage cin abinci, rayuwa mai amfani ba ta taimaka wa rage yawan sukari a cikin jini ba, don haka dole ne in canza zuwa jijiyar homon. Likita ya ba da shawarar yin amfani da Insulin Aspart. Na allurar 20 na miyagun ƙwayoyi a kowace rana har tsawon wata guda, bayan wannan yanayin ya daidaita.

Elena, 56 years old Ina amfani da insulin Aspart har shekara daya yanzu kuma, Dole ne in yarda, Na ji da kyau sosai. Kafin wannan, na sami rauni koyaushe, ciwon tsoka. A daidai lokacin da nake gabatar da raka'a 14 na miyagun ƙwayoyi a ko'ina cikin rana. A lokaci guda, Ina saka idanu sosai kan duk wani canje-canje a rayuwata ta yau da kullun, akan abin da nake daidaita yawan maganin yau da kullun.

Game da magani

An wajabta don rage taro na dextrose a cikin plasma.

Rage glucose yana farawa ta hanyar inganta shashi ta kyallen. Magungunan yana rage jinkirin samar da sukari a cikin hanta kuma yana inganta shigowar sel.

An wajabta lokaci guda don marasa lafiya da masu ciwon sukari na 1.

Hakanan an wajabta wa insulin na asphum biphasic don kamuwa da cututtukan type 2, idan har akwai tsayayya da masu maganin cututtukan fata.

Ayyukan wakilin guda daya a takaice. Yana faruwa minti 10-20 bayan aikace-aikacen. Tsawon lokacin bayyanuwa har zuwa 5 hours.

Matakan kashi biyu - har zuwa rana. Tasirin warkewa yana faruwa ne bayan mintina 10, saboda yana dauke da sinadarin horarwa na gajarta da matsakaici.

Siffofin aikace-aikace

Insulin Bifaxicum da Aspart suna cikin contraindicated a cikin marasa lafiya 'yan shekaru 6 da haihuwa. Ba a gudanar da bincike kan tasirin kwayoyi a jikin yaran ba. Likitocin ba su san yadda maganin zai shafi yanayin yarinyar ba.

Muna ba da ragi ga masu karanta shafinmu!

Ba a hana shan magani a lokacin lactation ba. An ba da izinin amfani idan haɗarin haɗari ga jariri ya zama ƙasa da fa'idodin ga uwa.

Amma ga marasa lafiya tsofaffi, wajibi ne don daidaita sashi. Canje-canje masu dangantaka da tsufa a cikin jiki na iya haifar da ƙarancin lafiya. Tun da yake aiki na gabobin ciki sun lalace, aikin maganin cututtukan jini yana cutar da yanayin.

Yin hulɗa tare da wasu kwayoyi

Magunguna waɗanda ke rage sukarin jini, waɗanda aka ɗauka a baka, suna haɓaka aikin masu aiki. Irin waɗannan kwayoyi ba da shawarar ba. Hypoglycemia yana haɓaka, yanayin yanayin ragewar glucose a ƙasa da ƙimar al'ada.

Anabolic steroids, Ketoconazole, Pyridoxine da sauran magunguna dangane da ethanol da tetracyclines, waɗanda ake amfani dasu lokaci guda tare da wannan maganin hypoglycemic, kuma suna haifar da raguwa mai yawa a cikin glucose jini.

Magungunan hana haihuwa, heparin da magungunan kashe kuɗaɗen da ake amfani da su don rage alamun tashin hankali na iya rage tasirin miyagun ƙwayoyi.