Akkuzid na miyagun ƙwayoyi: umarnin don amfani

Hada magunguna tare da tasirin antihypertensive, wanda ya hada da abubuwa guda biyu masu aiki: hinapril (mai hanawa ACE) da hydrochlorothiazide (diuretic) a haduwa uku.

Hinapril Mai kara kuzari karafarirani IIwanda shine saboda haɓakar ƙwayar fata adrenal (samarwa) aldosterone), yana rinjayar sautin jijiyoyin bugun jini kuma yana da tasirin vasoconstrictor. Hinapril hanawa ACE (nama da rarrabuwa) da kuma rage yawan motsa jiki na vasopressor da kuma motsa jiki aldosterone. Dakatar da mummunan tasiri karafarirani II haɓaka reninyana haifar da ƙara yawan aiki renin.

Ragewa BOKA yana faruwa ne daga tushen juriyar rage ƙwayar jijiyoyin koda da OPSSa lokaci guda, canji a fitarwa na zuciya, Yawan zuciya, rubin dunƙule na dunkulalliya da hauhawar jinin haila sune sakaci ko ma basa nan. Hinapril dan kadan yana rage asarar potassium wanda aikin yayi hydrochlorothiazidewanda, yana da tasirin diuretic, yana haɓaka aikin renin jini, yana inganta ɓoyewa aldosterone, yana haɓaka sinadarin potassium a cikin jini kuma yana ƙaruwa da fitar kansa ta hanjin kodan. Tasirin antihypertensive yana haɓakawa a cikin sa'a ɗaya kuma ya isa matsakaici bayan sa'o'i 3, yana ci gaba a cikin kullun.

Hydrochlorothiazide - yana nufin ƙungiyar diuretics, yana shafar aikin kodan, yana haɓaka haɓakar sodium, potassium, chlorides, bicarbonate ion da ruwa yayin rage sinadarin alli. Ana nuna tasirin diuretic bayan sa'o'i 2, matsakaicin sakamako shine bayan sa'o'i 4 kuma tsawon sa yana awanni 6-12.

Hadadden abubuwa masu aiki (quinapril da hydrochlorothiazide) yana bayar da ƙarin raguwa mai ma'ana BOKAfiye da aikin kowane ɗayansu daban-daban.

Pharmacokinetics

Duk abubuwa masu aiki ba sa tasiri ga juna.

Hinapril - An kai Cmax bayan awa 2. Matsayi na sha shine kusan 60%. Babban ɗauri ga garkuwar jini. A cikin hanta, biotransformed zuwa quinaprilatakasancewa mai karfi mai hanawa ACE. Kar ku shiga BBB. An cire shi a cikin mafi yawan kodan, T1 / 2 - kimanin sa'o'i 3.

Hydrochlorothiazide - yana da hankali sosai, matakin sha kashi 50-80%. An kai Cmax a cikin awa 1-3. Kar ku shiga BBB. Jiki ba ya metabolized, an cire shi ta hanyar kodan. T1 / 2 - daga 4 zuwa 15 hours.

Contraindications

• Babban hankali ga miyagun ƙwayoyi,
• a cikin sannesis - angioedema bayan magani tare da inhibitors ACE,
• Cutar Addison,
• rashin lafiya,
• shekaru zuwa shekaru 18
• ciwon sukari mellitus,
• ciki da lactation.
• furta na kodagazawar hanta
• kasawa lactases.

Akkuzid, umarnin don amfani (hanya da sashi)

Ana daukar Allunan Akkuzit sau 1 a rana ba tare da yin la’akari da yawan abinci ba. Thewarin da aka ba da shawarar farko ga marasa lafiya waɗanda ba su karɓi diuretic shine 10 mg + 12.5 mg (kwamfutar hannu guda ɗaya na Accuzit 10), idan ya cancanta, ana ƙara ƙaruwa na yau da kullun zuwa matsakaicin adadin yau da kullum na 20 MG + 25 MG (kwamfutar hannu guda ɗaya na Accuzit 20). A matsayinka na mai mulki, tasirin yana faruwa lokacin ɗaukar miyagun ƙwayoyi a cikin adadin sashi daga (10 +12.5 zuwa 20 +12.5) mg kowace rana. Marasa lafiya tsofaffi ba sa buƙatar gyaran kashi. A gaban ƙarancin rashi na marasa lafiya a cikin marasa lafiya, bai kamata a yi amfani da miyagun ƙwayoyi azaman maganin farko ba.

Yawan abin sama da ya kamata

Babban bayyanar cutar ta yawan ƙwayoyi tare da tsawaita amfani da miyagun ƙwayoyi a allurai mafi ƙoshin warkewa shine raguwa mai dorewa BOKA, hargitsi a cikin ruwa da daidaita ma'aunin lantarki, ya bayyana hypochloremia, hyponatremia, hypokalemia.

Haɗa kai

Tare da gudanar da sabis na Accuzide na lokaci guda tare da maganin rigakafi na kungiyar tetracycline tsari tsotsa tetracycline rage ta uku. Ba'a ba da shawarar don shirya shirye-shiryen lithium tare da diuretics ba, tunda diuretics suna rage ƙananan ƙwayar ɗan adam na lithium kuma haɗarin maye yana ƙaruwa sosai. Yayin ɗaukar tare da Accid ethanolopioid analgesics, barbiturates da Magunguna c don maganin hana tashin hankali na gaba daya hadarin ci gaba orthostatic hypotension. Tare da gudanarwa na lokaci daya na Accuzide tare da insulin ko cututtukan hypoglycemic daidaitawa sashi na kwatankwacin jami'ai ya zama dole. Hydrochlorothiazide a matsayin wani ɓangare na Akkuzid yana haɓaka aikin rigakafin magungunan rigakafi da aka ɗauka lokaci guda tare da shi.

Tare da gudanarwa na lokaci guda na magungunan corticosteroid tare da Accuid, haɓakar asarar potassium da sauran abubuwan lantarki suna yiwuwa. Yanayin aiki NSAIDs sa rauni da antihypertensive, diuretic da natriuretic aikin diuretics. Tare da kulawa na lokaci ɗaya na shakatawa na tsoka tare da Akkuzid, ana iya inganta aikin su.

Sashi da gudanarwa

Maganin da aka saba da shi na Accuid shine kwamfutar hannu guda (10 mg / 12.5 mg) a kowace rana. Likita na iya karuwa da kashi zuwa allunan guda biyu a rana, wanda za'a iya ɗauka tare sau ɗaya a rana ko daban - kwamfutar hannu ɗaya da safe, ɗaya da yamma.

Koyaushe ɗauki Accuzide kamar yadda likitanka ya umurce ka. Karka taɓa shan allunan fiye da likitanka suka bayar da shawarar ka.

Yi ƙoƙarin shan kwayoyin a lokaci guda na rana kowace rana, ba tare da la'akari da abincin ba.

• Idan kun manta shan kwafin magani, ku sha shi nan da nan, kamar yadda kuke tunawa, ba tare da jiran wani lokaci na gaba da za ku sha maganin ba. Kada ku ɗauki allurai biyu na magani.
• Idan kayi kuskuren shan kwalaben Akkuzid da yawa, sanar da likitanka nan da nan.Idan baza ku iya wannan ba, tuntuɓi sashen gaggawa na asibiti mafi kusa. Dauke kan kunshin magungunan, koda babu allunan da suka rage domin ma'aikatan asibitin zasu iya gano ko wane magani kuka sha.
• Ba da shawarar Accid ga yara. Ba a yi nazarin maganin ba a cikin marasa lafiya 'yan ƙasa da shekara 18.

Side sakamako

Kamar sauran magunguna da aka yi amfani da su don rashin lafiya, wani lokacin Accuzide na iya samun sakamako mara amfani (sakamako masu illa). Idan kun bunkasa waɗannan alamun, ya kamata ku nemi likitan ku.

• M bushe tari.
• Ciwon ciki, amai, gudawa, maƙarƙashiya, rashin jin daɗi, ƙwanƙwasa, dyspepsia, ko ciwon ciki.
• Ciwon kai, amai, amai, rashin bacci, rashin bacci, bacci, gajiya, rashin tausayi ko gajiya, ko kuma rauni na yau da kullun.
• Jin zafi a baya, kirji, tsokoki, ko haɗin gwiwa (gout).
• Fashin fata, ƙaiƙayi ko rashin kwanciyar hankali ga haske, amsawar fata.
• Cutar cututtukan koda (daga lokaci zuwa lokaci, idan likitanku yana zargin ci gaban cutar koda, likitan ku zai iya ba da gwajin fitsari).

Tasirin sakamako wanda zai iya faruwa ba da wuya ya haɗa da: giya mai yawa ba, bushewar bakin / makogwaro, asarar gashi, rashin ƙarfi, kamuwa da cuta na urinary (bushewar mucoal na iya haifar da kamuwa da cuta), tingling sensation a cikin hannu ko kafafu, huhun ciki, bacin rai. , rikice, rikicewa, tinnitus, hangen nesa mai kyau, dandano mara kyau, edema (yanki).

Idan kun bunkasa waɗannan alamun, ya kamata ku nemi likitan ku.

Idan kun sami nasarar kaiwa hari ta hanuwa, to ya kamata ku guji tuƙi da sauran hanyoyin.

Accuid na iya haifar da wasu canje-canje a hoton hoton. Sabili da haka, mai kula da lafiyar ku na iya ba da gwajin jini don kula da wannan. Idan kana da rauni, jin jiki mai yawan gaske, idan kuna da ciwon sukari kuma kun lura da karuwar glucose na jini, to ku sanar da likitanka kuma idan ya cancanta, zaku sami gwajin jini.

Abubuwan da zasu biyo baya suna da wuya sosai, amma suna da tsauri, don haka idan kuna da kowane, gaya wa likitan ku yanzunnan.

• Cutar Angioneurotic (kumburin fuska, harshe, trachea - na iya haifar da babbar wahala a cikin numfashi). A lokaci guda, angioneurotic edema na ciki da ciki (hanji na hanji) na iya haɓaka daban-daban. A wannan yanayin, zaku ji rashin lafiya; amai da zafin ciki na iya bayyana. Waɗannan ƙananan ba kasafai ba ne, amma halayen da suka dace na ainihi, kuma idan kun inganta su, nan da nan ku kira motar asibiti.
• Matsi a cikin kirji, ciwon kirji, bugun kirji, yawan ihu ko gazawar numfashi.
• Mai tsananin ciwon ama ko rauni a bakin. Idan kuna da matsalolin koda ko kuna da rarraba cututtukan haɗuwa da ƙwaƙwalwa, zaku iya haɓaka cutar neutropenia / agranulocytosis (isasshen ƙwayoyin farin jini), wanda zai haifar da kamuwa da cuta, makogwaro, ko zazzabi. Idan kuna da rarraba cututtukan ƙwayar cuta na haɗin kai, likitanku na iya ba ku gwaje-gwajen jini don kula da wannan yanayin.
• Yin rauni, musamman lokacin tsayawa, na iya nufin cewa saukar karfin jini ya yi ƙasa sosai. Wannan yanayin da alama zai iya tasowa lokacin da kuke shan diuretics (diuretics), wasu kwayoyi waɗanda ke rage karfin jini, da barasa idan kuna yawan zubar ruwa ko kuma kuna cikin ƙoshin lafiya lokacin da kuke shan shi tare da Accuzide. Idan idanunku sunyi duhu ko suna jin kamar kuna wucewa, ɗauki madaidaiciya ku kwance a wurin har sai ji ya shuɗe.
• Sauran cututtukan da ke da saurin lalacewa amma mummunan sakamako sun haɗa da launin raunin idanu da fata (jaundice), ciwo mai zafi a cikin ciki da baya (pancreatitis), rauni a cikin babba da ƙananan baya, ko wahalar magana (mai yiwuwa bugun jini).

Ciki

Amfani da magani Accuid contraindicated lokacin daukar ciki, mata suna shirin daukar ciki, haka kuma matan masu haihuwa wadanda basa amfani da hanyoyin ingantattun hanyoyin kariya.
Matan mata masu haihuwa da suke shan Accuside® yakamata su yi amfani da hanyoyin ingantaccen maganin hana haihuwa.
Idan ciki ya faru a lokacin jiyya tare da Accuzide, ya kamata a dakatar da miyagun ƙwayoyi da wuri-wuri.
Nadin masu hana ACE a lokacin daukar ciki yana tare da hadarin da ke tattare da bunkasa jijiyoyin zuciya da jijiyoyin jikin tayin. Bugu da kari, a kan tushen amfani da ACE inhibitors a lokacin daukar ciki, lokuta na oligohydramnios, haihuwar haihuwa, haihuwar yara tare da jijiyoyin jini, rashin aiki na renal, lalata ciki har da gazawar asali na kashin, hypoplasia na kasusuwa, kwangila na wata gabar jiki, craniofacial anomalies, pulmonary hypoplasia intrape, resonary hypoplasia , bude mahaifa, da kuma batun mutuwar tayi, da kuma mutuwar haihuwa. Sau da yawa, ana gano oligohydramnios bayan tayin ya lalata ba tare da matsala ba.
Ya kamata a lura da jarirai wadanda suka shiga cikin inhibitors na ACE domin gano yanayin rashin lafiyar, oliguria da hyperkalemia. Lokacin da oliguria ya bayyana, ya kamata a kula da hawan jini da ƙanshin koda.
Thiazides ya haye katangar mahaifa kuma ana samun su a cikin jinin igiyar cibiyar. Abubuwan da ba na teratogenic na thiazides sun hada da jaundice da thrombocytopenia na tayin da / ko jariri, kuma damar halayen wasu munanan halaye da aka lura a cikin manya kuma an yarda dasu.
ACE inhibitors, ciki har da hinapril, zuwa iyakataccen iya shiga cikin madara nono. Ana cire maganin Thiazide a cikin madarar nono. Ganin akwai yuwuwar yin mummunan illa ga jarirai, Ba za a yi amfani da Accuzide yayin shayarwa ba, kuma idan ya cancanta, ya kamata a daina shayar da jarirai.

Fom ɗin saki

shafin. shafi fim, 10 MG + 12.5 mg: 30 inji mai kwakwalwa.
shafin. shafi fim, 20 MG + 12.5 mg: 30 inji mai kwakwalwa.
shafin. shafi fim, 20 MG + 25 MG: 30 inji mai kwakwalwa.

Kwamfutar hannu 1Accuid ya ƙunshi: quinapril hydrochloride 10.832 MG, wanda ya dace da abun da ke ciki na kwayar ƙuruwar quinapril 10 mg
hydrochlorothiazide 12.5 MG.
Wadanda suka karu: lactose monohydrate - 32.348 mg, magnesium carbonate - 35.32 mg, povidone K25 - 4 mg, crospovidone - 4 mg, magnesium stearate - 1 mg.
Abun da keɓaɓɓun suturar fim: opadray ruwan hoda OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, baƙin ƙarfe mai ɗauke da baƙin ƙarfe, baƙin ƙarfe mai ruwan ƙarfe) - 3 MG, ƙwayoyin ganye - 0.05 mg.
Akkuzid kwamfutar hannu 1 ya ƙunshi: quinapril hydrochloride 21.664 MG, wanda ya dace da abun ciki na quinapril 20 MG.
hydrochlorothiazide 12.5 MG.
Mahalarta: lactose monohydrate - 77.196 mg, magnesium carbonate - 70.64 mg, povidone K25 - 8 mg, crospovidone - 8 mg, magnesium stearate - 2 mg.
Abun da keɓaɓɓun suturar fim: opadray ruwan hoda OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, baƙin ƙarfe mai launin shuɗi, baƙin ƙarfe mai ruwan ƙarfe) - 6 MG, ƙwayoyin ganye - 0.1 mg.
Kwamfutar hannu 1Accuid ya ƙunshi: quinapril hydrochloride 21.664 MG, wanda ya dace da abun ciki na quinapril 20 MG.
hydrochlorothiazide 25 MG
Abubuwan da suka dace: lactose monohydrate - 64.696 mg, magnesium carbonate - 70.64 mg, povidone K25 - 8 mg, crospovidone - 8 mg, magnesium stearate - 2 mg.
Abun da keɓaɓɓun suturar fim: opadray ruwan hoda OY-S-6937 (hypromellose, hyprolose, titanium dioxide, macrogol 400, baƙin ƙarfe mai launin shuɗi, baƙin ƙarfe mai ruwan ƙarfe) - 6 MG, ƙwayoyin ganye - 0.1 mg.

Sashi da gudanarwa

Akkuzid an yi shi ne don amfani da baki. Yawan cin abinci - lokaci 1 a rana, komai girman abincin.

An tsara marasa lafiyar da ba su shan maganin diuretic Accuzid 12.5 mg + 10 mg Allunan, 1 pc kowane. kowace rana. Idan ya cancanta, zai yuwu a rubuto Accuid 25 mg + 20 mg, 1 pc. kowace rana.

Ingantaccen ikon saukar karfin jini yawanci ana samunsa ta amfani da allurai na yau da kullun a cikin kewayon daga 12.5 mg + 10 mg zuwa 12.5 mg + 20 mg.

Sashi na lokaci don ƙungiyar marasa lafiya na musamman:

• lalacewar aikin na ɗan ƙarancin mai sauƙi (tsaftacewar kasa da 60 ml / min): Accuzide 12.5 mg + 10 mg - 1 pc. kowace rana
• aikin lalacewa na matsakaiciyar matsakaici (tsaftacewar halitta 60-30 ml / min.) kashi na farko na quinapril shine 5 MG tare da ƙarin titration, marasa lafiya na wannan rukuni ba a sanya su Accuzide azaman maganin farko ba,
• shekaru masu tasowa: Accuzide 12.5 MG + 10 MG - 1 pc. kowace rana, ba a bukatar daidaita sakin abu.

Side effects

Mummunan al'amuran da suka faru a cikin fiye da 1% na marasa lafiya suna karɓar quinapril a hade tare da hydrochlorothiazide:

• sigogi na dakin gwaje-gwaje: hypercreatininemia, hyperazotemia,
• sauran: ciwon kai, tsananin farin ciki, tashin zuciya, matsananciyar ciki, raunin narkewa, raunin kirji, ciwon ciki, raunin ciki, ciwon baya, cututtukan hoto ko farji, mashako, sinusitis, pharyngitis, bugun zuciya na sama, kamuwa da rashin bacci mai tarin yawa. bayyanar cututtuka na vasodilation, gajiya, cututtukan asthenic, rashin bacci.

Abubuwan haɗari waɗanda suka faru a cikin 0.5-1% na marasa lafiya suna karɓar quinapril a hade tare da hydrochlorothiazide:

• tsarin hematopoietic: raguwa a matakin leukocytes, platelet, granulocytes, hemolytic anemia,
• tsarin juyayi: bacin rai, rashin bacci, yawan tashin hankali, jin magana da tsotsewar gabar jiki,
• tsarin zuciya: palpitations, tachycardia, arrhythmia, angina pectoris, bugun zuciya, rashin karfin zuciya, raguwar hauhawar jini, hauhawar jini, tashin zuciya, matsananciyar damuwa, tashin zuciya, tashin hankali, tashin zuciya,
• tsarin numfashi: sinusitis, gazawar numfashi,
• tsarin narkewa: gurguwar ciki, rashin jin daɗi, bushewar mucous na bakin da makogwaro, angioedema, hanji, ƙwanƙwasa, hepatitis, gwajin aikin hanta mai rauni, zubar jini daga hanji,
• rashin lafiyan jiki: fatar fata, urticaria, pruritus, edema ta Quincke, daukar hoto, rashin lafiyar Stevens-Johnson, cututtukan ƙwayar cuta na ƙwayar cuta, ƙwaƙwalwar ƙwayar cuta, halayen ƙwayar cuta, wucewar gumi,
• tsarin musculoskeletal da kashin haɗin gwiwa: arthralgia,
• tsarin kwayoyin halittar jini: cututtukan urinary fili, tabarbarewa na dan lokaci, gazawar cutar koda, gazawar iko,
• sashen hangen nesa: raunin gani,
• sauran halayen: hyperkalemia, alopecia, a hade tare da shirye-shiryen zinare: tashin zuciya, amai, hyperemia na fuska, raguwar hauhawar hauhawar jini, cututtukan da ke kama da cutar mura.

Wadannan alamu sune halayen shaye-shaye na Akkuzid: rikice-rikice na metabolism na ruwa-gishiri, raguwar hauhawar jini, raguwar karuwa a cikin yanayin tilasta diuresis. A hade tare da glycosides na zuciya, yiwuwar haɓaka arrhythmias yana ƙaruwa.

Doaukar magani mafi yawa: dakatar da miyagun ƙwayoyi, lavage na ciki, sarrafawa na baka na adsorbents, gudanarwa na ciki (iv) na 0.9% maganin sodium chloride, mai tallafawa da daidaitaccen maganin warkewa.

Umarni na musamman

Akwai shaidar lokuta na angioedema na wuyansa da fuska yayin jiyya tare da masu hana ACE, ciki har da cikin 0.1% na marasa lafiya da ke karɓar hinapril. Game da angioedema na fuska, harshe, muryoyin wucin gadi, idanun ko laryngeal yi da wahala numfashi, saukar da abinci, Akkuzid ya kamata a soke shi nan da nan. Yakamata a bawa mai haƙuri magani sosai kuma ya lura da yanayinsa har sai bayyanar cututtukan edema sun shuɗe, ana iya amfani da antihistamines don rage su. Tare da angioedema wanda ya shafi maƙarƙashiya, sakamako mai mutuwa yana yiwuwa. Idan, saboda kumburi na muryoyin muryoyi, harshe, ko maƙogwaro, ci gaban hanawar hanya zai yuwu, to yakamata a gudanar da isashen lafiya na gaggawa, gami da gudanar da aikin sikandire na maganin adrenaline a 1: 1000 (0.3-0.5 ml).

A cikin marasa lafiyar da suka yi fama da cutar angioedema wacce ba ta da alaƙa da ɗaukar Accuzide da ACE inhibitors, da yiwuwar ci gabanta yana ƙaruwa da amfani da magungunan wannan rukunin.

Accuzide na iya haifar da raguwa na lokaci kaɗan a cikin karfin jini, duk da haka, ba sau da yawa fiye da tare da monotherapy tare da abubuwan aiki duka biyu. Yawancin hypotension yana da alaƙa da hauhawar jijiyoyin jini marasa ƙarfi, amma kuma yana iya haɓakawa a cikin marasa lafiya tare da rage yawan BCC, alal misali, bayan maganin diuretic, saboda ƙarancin gishiri mai ƙoshin abinci ko maganin hemodialysis.

Idan akwai alamun alamun tashin hankali, mara lafiyar ya kwanta. Idan ya cancanta, ana samun jiko na 0.9% sodium chloride bayani. Ragewar saukar karfin jini na dan lokaci baya buƙatar cirewar Akkuzid, kodayake, daidaita sikari ya zama dole.

A cikin marasa lafiya da cututtukan zuciya na rashin lafiya tare da / ba tare da isasshen ƙwayar cuta ta yara ba, shan Accuzide na iya haifar da raguwar raguwar hauhawar jini, tare da oliguria da azotemia. A cikin mafi yawan lokuta, ci gaban lalacewa mara nauyi har ma da mutuwa mai yiwuwa ne. Wannan rukuni na marasa lafiya yakamata a karba a karkashin kulawar likita.

Da wuya, Accuzide far zai iya kasancewa tare da rage girman granulocytes a cikin jini zuwa matsanancin matakin da kuma rage karfin jini na jini, yayin da adadin leukocytes a cikin jini dole ne a sarrafa shi.

Bayyanar ƙananan alamun alamun kamuwa da cuta (zazzabi, ciwon makogwaro) yana nuna buƙatar ganin likita, saboda suna iya nuna alamar neutropenia.

Ba a sanya Accuzide don ƙarancin lalacewa na ƙwayar cuta ba (tsaftacewar creatinine kasa da 30 ml / min), tunda azotemia da sakamako mai tarawa na iya haifar da amfani na tsawan lokaci.

A cikin marasa lafiya da mummunan rauni na zuciya, yin amfani da inhibitors na ACE na iya haifar da raguwa mai yawa a cikin karfin jini, wanda hakan na iya haifar da raguwar adadin fitsari da kodan ke fitarwa da / ko kuma hauhawar matakan jini na samfuran abubuwan haɓaka metabolism da kodan ke kwance. Rashin lalacewa mai yawa da / ko mutuwa ba a fitar da su.

Yayin jiyya tare da Accuside, yakamata a kula da karfin jini, aikin koda, da matakan plasma electrolyte. Ya kamata a guji yin amfani da quinapril tare da jami'ai masu aiki a kan tsarin renin-angiotensin-aldosterone (RAAS). Wannan haɗin yana bayar da shawarar ne kawai a cikin maganganun mutum a ƙarƙashin tsananin kulawa na aikin renal da matakan ƙwayoyin plasma.

A cikin marasa lafiya da ke fama da cutar hepatic ko ciwan hanta na ci gaba, ana amfani da Accuzide tare da taka tsantsan, tunda ƙananan canje-canje a cikin ma'aunin ruwa-electrolyte na iya haifar da haɓakar cutar hepatic.

Kimanin 2% na marasa lafiya da aka bi da quinapril suna da hyperkalemia. Ba a bada shawarar yin amfani da Accuzide da potassium-spure diure na lokaci guda ba.

Rashin ƙwayar Chloride da ke haɗuwa da ɗaukar Accuzide yawanci mai laushi ne kuma yana buƙatar kulawa ta musamman ne kawai a cikin abubuwan da aka keɓe (alal misali, tare da cututtukan hanta da / ko kodan).

A cikin yanayin zafi, ɗaukar Accuzide a cikin marasa lafiya da ke da matsala na lalacewa na iya haifar da raguwar sodium a cikin jiki. Wannan yanayin yana buƙatar maye gurbin magani.

Hinapril yana rage fitowar alli, yana haɓaka fitowar magnesium a cikin fitsari, wanda zai iya haifar da hypomagnesemia.

Quinapril na iya haɓaka cholesterol, uric acid da triglycerides. Yawancin lokaci waɗannan tasirin suna da laushi, duk da haka, a wasu yanayi, zasu iya haifar da ci gaban gout da ciwon sukari.

Shan magunguna masu yawa na Accuzide na iya haifar da hyperkalemia (wuce kima na ≥100 MG kowace rana), yana wargaza karfin matakan glucose na jini. Yayin aikin jiyya, ana bada shawara don sarrafa matakin glucose na plasma kuma, idan ya cancanta, daidaita tsarin maganin hypoglycemic.

Kafin tiyata, mara lafiya ya gargadi likita cewa yana shan Accuzide.

A lokacin da ake amfani da magani, an lura da cigaban tari wanda ba ya haihuwa. Yana wucewa bayan dakatar da maganin.

Hydrochlorothiazide na iya haifar da haɓaka rashin girma na kusurwa glaucoma da myopia na ɗan lokaci. Idan ba a yi maganin da ya dace ba, mummunar cutar glaucoma ta cika da asarar hangen nesa.

Ya kamata a kiyaye mata masu haihuwa yayin amfani da Akkuzid yayin daukar ciki. Idan ya fara aiki, an soke maganin da wuri-wuri.

A lokacin jiyya tare da Accuside, ya kamata a yi taka tsantsan yayin aiwatar da nau'ikan ayyuka waɗanda ke buƙatar ƙara kulawa da saurin halayen psychomotor, gami da tuki mota da sauran hanyoyin hadaddun, musamman a farkon jiyya.

Hulɗa da ƙwayoyi

• diuretics: Kara tasirin sakamako na Akkuzid,
• ethanol, abubuwan da ake amfani da su na barbituric acid, narcotic analgesics: karuwar hadarin rushewar orthostatic,
• glucocorticosteroids (GCS), kwayoyin adrenocorticotropic (ACTH): karuwar asarar electrolytes, musamman potassium,
• digoxin: karuwar yiwuwar shan narkexin (gami da haifar da damuwa ga damuwa),
• cututtukan hypoglycemic: haɓakar haɓakar hyperglycemia, ƙara haƙuri haƙuri,
• vasoconstrictor kwayoyi: raguwa a cikin tasirin su,
• tetracycline da sauran magunguna waɗanda ke hulɗa tare da magnesium: rage yawan abubuwan da suke aiki,
• kwayoyi masu dauke da sinadarin Libaum: rage zubar kananan yara na lithium, karuwar yiwuwar kamuwa da cutarwa, karuwar hadarin da ke cikin maye,
• sauran magungunan antihypertensive: haɓaka aikinsu, musamman beta-blockers da ganglion blockers,
• magungunan anti-inflammatory marasa steroidal (NSAIDs): rauni na hypotensive, diuretic, natriuretic action of Accuzide, rashi aiki na renal a cikin tsofaffi marasa lafiya, kazalika da rage BCC da renal dysfunction,
• kwayoyi masu haɓaka matakin potassium a cikin jini: karuwa a cikin yiwuwar haɓaka hyperkalemia,
• ion canzawa: karancin sha na hydrochlorothiazide,
• anti-gout magunguna: mai rauni kula da yanayin marasa lafiya da gout, karuwa a mita na rashin hankalin halayen to anti-gout abubuwa,
• miyagun ƙwayoyi, magungunan narkewa, magunguna don rage karfin jini: karuwar tasirin sakamako na Accuzide,
• immunosuppressants, cytostatics, allopurinol, procainamide: haɓakar haɗarin haɓakar leukopenia,
• cardiac glycosides da sauran magunguna waɗanda zasu iya haifar da haɓaka nau'in ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta: karuwar haɗarin hypokalemia, karuwar tasirin mai guba,
• aliskiren: yuwuwar an dakatar da ayyukan RAAS sau biyu, wanda aka bayyana ta hanyar raguwar hauhawar jini, canje-canje a aikin koda, hyperkalemia,
• mTOR da DPP-4 masu hana enzyme: karuwar yiwuwar haɓakar edema na Quincke.