Moflaxia® (Moflaxia)

* Rashin hankali shine moxifloxacin an tabbatar dashi ta bayanan asibiti.

** Ba'a bada shawarar amfani da miyagun ƙwayoyi na Moflaxia don maganin cututtukan da ke haifar da damuwa S. aureustsayayya da methicillin (MRSA). Game da wadanda ake zargi ko tabbatar da kamuwa da cuta ta hanyar MRSA, magani tare da magungunan ƙwayoyin cuta masu dacewa da yakamata ya kamata a tsara.

Ga takamaiman nau'in, yaduwar karɓar juriya na iya bambanta ta yankin yanki da tsawon lokaci. Dangane da wannan, lokacin gwada gwajin ƙwayar damuwa, yana da kyau a sami bayanai na gida game da juriya, musamman ma don magance cututtukan cututtukan fata.

Idan a cikin marasa lafiya ana yin jiyya a asibiti, darajar AUC / MIC₉₀ya zarce 125, da C_max cikin jini / MIC₉₀ yana cikin kewayon 8-10, wannan yana nuna haɓaka asibiti. A cikin marasa lafiya, ƙimar waɗannan sigogi marasa galibi galibi ƙasa ne: AUC / MIK₉₀ >30–40.

*AUIC - yanki a ƙarƙashin inhibitory curve (AUC / MIK rabo₉₀)

Pharmacokinetics

Damuwa. Lokacin da ake gudanar da shi, moxifloxacin yana shan cikin sauri kuma kusan gaba daya. Cikakken bayanin bioavailability kusan kashi 91%. Magungunan magani na moxifloxacin lokacin da aka karɓa a kashi 50 zuwa 1200 mg sau ɗaya, kazalika da 600 mg / rana tsawon kwana 10, layi ne. An cimma matsayin daidaituwa tsakanin kwanaki 3.

Bayan kashi daya na 400 MG moxifloxacin C_max a cikin jini jini an kai shi tsakanin awanni 0.5-4 kuma shine 3.1 mg / l. Bayan sarrafa bakin mutum na 400 MG na moxifloxacin 1 lokaci a rana C_{ss (max)} da C_{ss (min)} sune 3.2 da 0.6 mg / l, bi da bi.

Lokacin ɗaukar moxifloxacin tare da abinci, akwai ƙara ƙaruwa a cikin T_max (a 2 h) da kuma raguwa kaɗan a C_max (kusan 16%), yayin da tsawon lokacin sha bai canza ba. Koyaya, waɗannan bayanan basu da dacewa a asibiti, kuma ana iya amfani da moxifloxacin ba tare da la'akari da lokacin cin abinci ba.

Rarraba. Moxifloxacin an rarraba shi cikin sauri a kyallen takarda da gabobin kuma yana ɗaure wa garkuwar plasma (galibi tare da albumin) kusan kashi 45%. V_d kusan 2 l / kg.

Babban adadin moxifloxacin, wanda ya wuce wadanda ke cikin jini na plasma, an kirkireshi ne a cikin huhun huhu (wanda ya hada da kwayar epithelial, alveolar macrophages), sinadarin paranasal (maxillary da ethmoid labyrinth), polyps na hanci, foci of kumburi (a cikin abinda ke jikin blister na raunukan fata) . A cikin ruwa mai tsaka-tsakin yanayi da na yau da kullun, ana tantance moxifloxacin ta hanyar kyauta, wacce ba ta da furotin, a inda ya fi girma a cikin jini. Bugu da kari, an gano manyan abubuwan da ake kira moxifloxacin a cikin kasusuwa na gabobin ciki, da ruwa na ciki, da gabobin mace.

Tsarin rayuwa. Moxifloxacin yana gudanar da aikin biotransformation na kashi na 2 kuma an cire shi daga jiki ta hanyar kodan, haka kuma ta cikin hanji, duka biyun kuma ba canzawa ba kuma yana aiki a cikin mahadi sulfo na aiki (M1) da glucuronides (M2). Moxifloxacin ba biotransformed din ta microsomal cytochrome P450 tsarin. Metabolites M1 da M2 suna nan a cikin jini na plasma a cikin abubuwan da ke ƙasa da ƙananan mahaifa. Dangane da sakamakon binciken kwaskwarima, an tabbatar da cewa wadannan metabolites ba su da mummunan tasiri ga jiki dangane da aminci da juriya.

Kiwo. T_1/2 moxifloxacin shine kimanin awanni 12. Matsakaicin tsabtataccen izinin bayan aiki a kashi 400 MG shine 179 - 246 ml / min.

Rashin izini shine 24-53 ml / min. Wannan yana nuni da sake dawo da tushen tubular m of moxifloxacin.

Matsakaicin ma'auni na farkon farawa da kuma kashi na 2 metabolites kusan kashi 96-98 ne, wanda ke nuna rashin isowar metabolism. Kimanin kashi 22% na kaso ɗaya (400 MG) ana jujjuya shi daga kodan, kusan 26% - ta cikin hanji.

Pharmacokinetics a cikin kungiyoyin haƙuri daban-daban

Zamani, jinsi da kabilanci. Binciken masana kan magunguna na moxifloxacin a cikin maza da mata sun bayyana bambance-bambance a cikin 33% cikin yanayin kungiyar AUC da C_max . Rashin moxifloxacin bai dogara da jinsi ba. Bambanci a cikin AUC da C_max sun kasance saboda bambance-bambance a cikin nauyi maimakon jinsi, kuma ba a ɗaukar su da mahimmanci a asibiti.

Babu wani bambance-bambancen asibiti a cikin magungunan moxifloxacin a cikin marasa lafiya na kabilu daban-daban da shekaru daban-daban.

Yara. Ba a yi nazarin magungunan magungunan moxifloxacin a cikin yara ba.

Paarancin aiki na haya. Babu wasu canje-canje masu mahimmanci a cikin pharmacokinetics na moxifloxacin a cikin marasa lafiya da ke fama da rauni na aikin renal (ciki har da marasa lafiya tare da Cl creatinine 2) da kuma marasa lafiya da ke fama da ci gaba da rashin lafiyar jijiyoyin jini da tsawaita yanayin motsa jiki na yanayin motsa jiki.

Rashin aikin hanta. Babu wasu bambance-bambance masu mahimmanci a cikin taro na moxifloxacin a cikin marasa lafiya da raunin aikin hanta (azuzuwan aji-yaro da A da B) idan aka kwatanta da lafiya masu sa kai da marasa lafiya da aikin hanta na al'ada.

Alamun magungunan Moflaxia ®

Cututtuka da cututtuka masu kumburi da ke haifar da ƙwayoyin cuta da ke haifar da moxifloxacin:

wuce gona da iri na mashako,

bazuwar cututtukan fata na fata da ƙananan tsarin,

maganin cutar huhu da al'umma ke samu, gami da cutar huhun da al’umma ta samu, abubuwanda suka haifar da wasu nau'ikan kwayoyin cuta tare da juriya da yawa *,

rikitaccen cututtuka masu rikitarwa na fata da ƙananan tsarin (ciki har da ƙafafun da ke ɗauke da cutar),

rikitattun cututtukan ciki-ciki, ciki har da cututtukan polymicrobial, ciki har da cikin rashin lafiyar,

cututtukan mahaifa da ba a haɗa su da gabobin pelvic (ciki har da salpingitis da endometritis).

*Kwayar cutar huda ciki tare da juriya na kwayar cuta da yawa sun hada da maganin penicillin mai jurewa da raunin da zai iya magance biyu ko fiye da maganin rigakafi daga ƙungiyoyi kamar su penicillins (tare da MICs ≥ 2 μg / ml), cephalosporins na biyu (cefuroxime), macrolides, tetracyclines da trimethoprim / Sankarin Shinzo Wajibi ne a yi la’akari da ƙa’idodin hukuma na yanzu kan ƙa’idodin amfani da abubuwan hana ƙwayoyin cuta.

Contraindications

hypersensitivity to moxifloxacin, wasu quinolones ko kowane bangaren magani,

tarihin jijiyar cututtukan jijiya wanda ya samo asali sakamakon maganin rigakafi na jerin cutinolone,

marasa lafiya na wadannan rukuni: na haihuwa ko samu rubuce rubuce na tsawon lokaci na QT tazara, rikicewar electrolyte, musamman maras kyau hypokalemia, asibiti mai mahimmanci bradycardia, asibiti mai mahimmanci mara lafiyar rauni tare da rage raguwar ventricular ejection fraction, tarihin rhythm hargitsi tare da bayyanar cututtuka na asibiti (a cikin asibiti da kuma karatun karatun bayan gudanar da moxifloxacin, an lura da wani canji a cikin sigogi na zuciya. an samu a tsawanta tsakanin tait ɗin QT),

yi amfani da wasu magunguna waɗanda ke haɓaka tsarukan QT,

marasa lafiya da ke fama da rauni na hanta (Tsarin yara-Pugh class C) da kuma marasa lafiya da haɓaka ayyukan transaminase fiye da sau 5 sama da VGN (saboda ƙarancin adadin bayanan asibiti),

lokacin shayarwa,

shekaru zuwa shekaru 18.

Tare da kulawa: cututtuka na tsakiya juyayi tsarin (ciki har da waɗanda ke da hannu da hannu a cikin tsakiyar juyayi tsarin), predisposing ga seizures da kuma ragewa ƙwanƙwasa na m, marasa lafiya da tarihin psychoses da / ko wasu cututtuka na shafi tunanin mutum, marasa lafiya da yiwuwar proarrhythmic yanayi (musamman a mata da tsofaffi marasa lafiya ), kamar ischemia na myocardial mai mahimmanci da kamawar zuciya, marasa lafiya tare da cirrhosis, myasthenia gravis gravis, gudanarwa na lokaci guda tare da magunguna masu rage ƙwayar potassium, marasa lafiya tare da tsinkayen kwayoyin halitta ko kasancewar ainihin ƙarancin glucose-6-phosphate dehydrogenase.

Haihuwa da lactation

An kare lafiyar amfani da moxifloxacin lokacin daukar ciki, saboda haka amfani da shi ya kewaya. An bayyana yanayin lalacewar lalacewar lalacewar yara a cikin yaran da ke karɓar wasu quinolones, duk da haka, bayyanar da wannan tasirin a cikin tayin (lokacin da mahaifiyar tayi amfani da shi a lokacin daukar ciki).

Karatun dabbobi sun gano yawan guba. Ba a san yiwuwar haɗarin ga mutane ba.

Kamar sauran quinolones, moxifloxacin yana haifar da lalata lalatattun manyan gidajen abinci a cikin dabbobi da suka girma.

Karatuttukan bincike na farko sun gano cewa karamin adadin moxifloxacin an kebe shi a cikin madara. Ba'a samun bayanai game da amfanin sa a cikin mata yayin shayarwa. Saboda haka, amfani da moxifloxacin lokacin shayarwa yana da hani.

Side effects

Bayanai game da mummunan halayen da aka rubuta tare da yin amfani da moxifloxacin 400 MG (ta bakin, tare da mataki na warwa (iv gudanar da moxifloxacin da ke biye da maganin baka) da iv kawai) an samo su daga karatun asibiti da saƙonni na tallan-bayan (a cikin rubutun). Abubuwan da ba a sani ba da aka lissafa a cikin "yawanci" ƙungiyar sun faru tare da mita a ƙasa da 3%, banda tashin zuciya da zawo.

An tsara tazarar kamar haka: sau da yawa (daga ≥1 / 100 har da haɗarin haɗari ga rayuwa) A bangaren metabolism da abinci mai gina jikiAbun Ciwon cikiHyperglycemia, hyperuricemiaHypoglycemia Rashin hankaliDamuwa, rashin hankalin psychomotor / tashin hankaliLabarin halin motsin rai, bacin rai (a lokuta da wuya sosai, hali tare da sha'awar cutar da kai, kamar tunani kai tsaye ko ƙoƙarin kashe kansa, mai yiwuwa ne), tsadar abubuwaFassara, abubuwanda suka shafi tunanin mutum (wadanda za'a iya nunawa cikin halayyar su da cutar da kai, kamar tunani kai tsaye ko kokarin kisan kai) Daga tsarin juyayiCiwon kai, danshiParesthesia / dysesthesia, rashin iyawa game da dandano (ciki har da, a lokuta mafi ƙaranci, agovesia), rikicewa da rarrabuwa, rikicewar bacci, rawar jiki, tashin hankali, matsananciyar barci, nutsuwa.Hypesthesia, rashin jin warin kamshi (gami da cutar rashin damuwa), mafarki mai ban tsoro, daidaituwar daidaituwa (gami da rashi mara nauyi saboda rashi ko vertigo, a lokuta da ƙarancin yanayi wanda ke haifar da rauni a sakamakon lalacewa, musamman ma a cikin tsofaffi marassa lafiya), raunin jijiyoyi tare da bayyanar cututtuka daban-daban (i.e. h. seizures babban mal), rashin kula, karancin magana, rashin amnesia, neuropathy na gefe da polyneuropathyHyperesthesia A wani bangare na bangaren hangen nesaRashin gani na gani (musamman tare da amsawa daga tsarin juyayi na tsakiya)Lossarancin hangen nesa na ɗan lokaci (musamman akasin abin da aka samu daga tsarin juyayi) Nau'in ji da ji na labyrinthineTinnitus, raunin ji, gami da kururuwa (yawanci ana gyarawa) Daga zuciya da jijiyoyin jiniTsawaita tazara na QT a cikin marasa lafiya tare da hypokalemia concomitantTsakanin tsarancin tsayi na QT, palpitations, tachycardia, vasodilationVentricular tachyarrhythmias, syncope, ƙaruwa / raguwa a cikin karfin jiniNonspecific arrhythmias, polymorphic ventricular tachycardia, cardiac kama (akasari a cikin mutane masu yanayin da ke faruwa game da arrhythmias, kamar muhimmiyar ƙwayar bradycardia, myecardial ischemia) Daga tsarin numfashi, kirji da gabobin jikiRage numfashi (gami da yanayin asthmatic) Daga cikin hanjiCiwon ciki, amai, ciwon ciki, zawoRage ci da rage cin abinci, maƙarƙashiya, dyspepsia, flatulence, gastroenteritis (banda na erosive gastroenteritis), ƙara yawan ƙwayoyin amylase na plasmaDysphagia, stomatitis, pseudomembranous colitis (a cikin mafi yawan lokuta ƙarancin dangantaka da rikitarwa na rayuwa) A wani ɓangaren hanta da ƙwayar biliaryActivityara ayyukan hepatic transaminasesTabarbarewar hepatic (gami da haɓaka aikin LDH), haɓaka tattarawar bilirubin, ƙara yawan ayyukan GGT, ƙara yawan ƙwayar cutar plasma na alkaline phosphataseJaundice, hepatitis (galibi cholestatic)Cutar hepatitis mai kamuwa da cuta, mai yiwuwar haifar da lalacewar hanta na haɗari ga rayuwa (gami da shari'oin masu kisa) A wani ɓangaren fata da ƙwaƙwalwar fataAbubuwan da suka shafi fata mai ban tsoro, irin su ciwo na Stevens-Johnson ko mai guba da keɓaɓɓen ƙwayar cuta (yiwuwar haɗarin rayuwa) Daga musculoskeletal da nama mai haɗuwaArthralgia, myalgiaTendonitis, ƙara sautin tsoka da ƙuraje, rauni na tsokaTendon ruptures, amosanin gabbai, raunin cuta saboda lalacewar tsarin musculoskeletal, ƙara alamun bayyanar myasthenia gravis gravis Daga kodan da hujin hanjiGuban ruwa (wanda ya haifar da zawo ko rage yawan ruwa ruwa)Imarancin aikin yara, gazaha koda (sakamakon rashin ruwa, wanda kan iya haifar da lalacewar koda, musamman a cikin tsofaffi marassa lafiya da ke fama da rauni na koda) Janar cuta da rikice-rikice a wurin allurarAbubuwan da Al'aura ke ciki / JikoJanar malaise, ciwo mara iyaka, yawan yin gumi, phlebitis / thrombophlebitis a wurin da jikoKurajewa

Halin da ke tattare da halayen masu biyo baya ya kasance mafi girma a cikin rukunin masu karɓar maganin: sau da yawa - ƙara yawan aikin GGT, wanda ba a taɓa gani ba - ventricular tachyarrhythmias, rage karfin jini, edema, cututtukan cututtukan cututtukan fata (a lokuta mafi wuya wadanda ke da alaƙa da rikice-rikice na rayuwa), yanke hukunci tare da bayyanannun asibitoci ( gami da tashin hankali babban mal), hallucinations, lalacewar aikin na koda, gazawar renal (sakamakon rashin ruwa, wanda zai iya haifar da lalacewar koda, musamman a cikin tsofaffi marasa lafiya da ke fama da raunin ƙwayar cutar koda).

Haɗa kai

Tare da yin amfani da lokaci ɗaya tare da atenolol, ranitidine, ƙari-mai ɗauke da alli, theophylline, cyclosporine, rigakafi don maganin baka, glibenclamide, itraconazole, digoxin, morphine, probenecid (rashi na rashin mahimmancin hulɗar asibiti tare da moxifloxacin da aka tabbatar ba a tabbatar da shi ba).

Magunguna waɗanda ke tsawaita Tsakanin QT. Zai yuwu ayi la'akari da tasirin tasirin QT na moxifloxacin da sauran kwayoyi da suka shafi tsawan QT nazara. Saboda amfani da moxifloxacin na lokaci guda da kwayoyi wadanda suka shafi tsawan tazara na QT, haɗarin haɓakar ventricular arrhythmias, gami da polymorphic ventricular tachycardia, yana ƙaruwa.

Yin amfani da moxifloxacin na lokaci daya tare da kwayoyi masu zuwa wadanda suka shafi tsawan tsaka-tsakin QT an sanya su:

- Class IA antiarrhythmic kwayoyi (gami da quinidine, hydroquinidine, melopyramide),

- Class III antiarrhythmic kwayoyi (gami da amiodarone, sotalol, dofetilide, ibutilide),

- magungunan ƙwayoyin cuta (ciki har da phenothiazine, pimozide, sertindole, haloperidol, sultopride),

- magungunan antimicrobial (sparfloxacin, erythromycin (iv), pentamidine, magungunan antimalarial, musamman halofantrine),

- antihistamines (terfenadine, astemizole, misolastine),

- wasu (cisapride, vincamine (iv), bepridil, diphemanil).

Antacids, multivitamins da ma'adanai. Yin amfani da moxifloxacin lokaci guda tare da antacids, multivitamins da ma'adanai na iya haifar da lalacewa na moxifloxacin, saboda samuwar chelate gidaje tare da caca masu yawa waɗanda ke cikin waɗannan kwayoyi. Sakamakon haka, haɗuwa da moxifloxacin a cikin jini na jini na iya zama ƙasa da ƙimar yadda ake so. A wannan batun, magungunan antacid, magungunan antiretroviral (misali didanosine) da sauran magunguna waɗanda ke ɗauke da magnesium ko aluminum, sucralfate da sauran magunguna waɗanda ke ɗauke da baƙin ƙarfe ko zinc ya kamata a yi amfani dasu aƙalla 4 hours kafin ko 4 hours bayan baka na moxifloxacin.

Warfarin. Tare da amfani lokaci guda tare da warfarin, PV da sauran sigogin jini ba su canzawa.

Canza darajar INR. A cikin marasa lafiya suna karɓar anticoagulants tare da maganin rigakafi, incl. tare da moxifloxacin, akwai lokatan lokuta na ƙara yawan aikin anticoagulant na magungunan anticoagulant. Abubuwan haɗari sune kasancewar wata cuta mai kamuwa da cuta (da kuma tsarin kumburi), shekaru da kuma yanayin mai haƙuri. Duk da gaskiyar cewa ba a gano hulɗar tsakanin moxifloxacin da warfarin ba, a cikin marasa lafiya da ke karɓar waɗannan magunguna a lokaci guda, ya zama dole don saka idanu cikin INR kuma, idan ya cancanta, daidaita kashi na maganin rashin daidaituwa.

Digoxin. Moxifloxacin da digoxin basa tasiri sosai ga tsarin sashin magunguna. Tare da maimaita allurai na moxifloxacin C_max plasma digoxin ya karu da kusan 30%, yayin da ƙimar AUC da C_min digoxin bai canza ba.

Carbon mai aiki. Tare da yin amfani da carbon da moxifloxacin mai aiki a lokaci daya na adadin 400 MG na baka, tsarin bioavailability na moxifloxacin yana rage fiye da 80% a sakamakon raguwa a cikin shan shi. Game da yawan abin sama da ya wuce, amfani da carbon mai aiki a farkon matakin sha, yana hana kara haɓakawa cikin tsarin.

Sashi da gudanarwa

A ciki Shafin 1. (400 MG) lokaci 1 kowace rana tare da cututtukan da aka nuna a sama. Karka wuce shawarar da aka bada shawarar. Ya kamata a hadiye allunan duk, ba tare da taunawa ba, tare da isasshen ruwan, ba tare da la'akari da lokacin cin abincin ba.

Tsawon lokacin jiyya. An ƙaddara ta wurin da tsananin kamuwa da cuta, kazalika da sakamako na asibiti:

- exacerbation na kullum mashako 5-10 kwanaki,

- m sinusitis 7 kwana,

- cututtukan da ba a haɗa su ba daga fata da ƙananan sassan jikin 7 na kwana,

- ciwon huhu da al'umma ta samu, jimlar yawan yin lada (iv gwamnatina tare da kulawar baka) kwana 7-14,

- rikice-rikice masu rikicewar fata da ƙananan tsarin jiki - jimlar lokacin aikin mataki-mataki-mataki tare da moxifloxacin (gudanarwa na iv tare da gudanar da maganin baka) kwana 7-21,

- rikitarwa ciki-ciki rikitarwa - jimlar lokacin yin magani (iv tare da maganin baka) shine kwanakin 5-14,

- Cututtukan kumburi marasa illa na gabobin pelvic har tsawon kwanaki 14.

Karka wuce lokacin da aka bayar da shawarar magani. Dangane da nazarin asibiti, tsawon lokacin jiyya tare da Moflaxia a cikin allunan na iya kaiwa kwanaki 21.

Groupsungiyoyin haƙuri na musamman

Tsufa. Ba a buƙatar sauya tsarin sashi a cikin tsofaffi marasa lafiya ba.

Yara. Ba a tabbatar da inganci da amincin amfani da moxifloxacin a cikin yara da matasa ba.

Rashin aikin hanta. Marasa lafiya da ke fama da rauni na hanta (Kwatanta Yara-Pugh A da B) ba sa buƙatar sauya jigilar magunguna (don amfani a cikin marasa lafiya da ke fama da cutar cirrhosis, duba “Umarnin na Musamman”).

Paarancin aiki na haya. A cikin marasa lafiya da ke fama da rauni na aikin ƙirar ƙira (ciki har da gazawar ƙarancin na renal tare da Cl creatinine ≤30 ml / min / 1.73 m 2), kazalika a cikin marasa lafiya da ke ci gaba da aikin ci gaba da rashin lafiyar jijiyoyin jiki da aka tsawaitawa, canjin yanayin magani ba a buƙata.

Kabilanci. Ba a buƙatar sauya tsarin sashi ba a cikin marasa lafiya na kabilu daban-daban.

Yawan abin sama da ya kamata

Akwai iyakantaccen shaidar tabbatar da yawan ƙwayar moxifloxacin. Ba'a lura da sakamako masu illa lokacin amfani da moxifloxacin a cikin kashi na 1200 mg sau ɗaya kuma 600 MG na kwana 10 ko fiye.

Jiyya: Idan an sami yawan abin sama da ya kamata, mutum ya kamata ya bishe shi ta hanyar asibiti kuma a gudanar da aikin tallafawa alamomin ta hanyar ECG. Yin amfani da carbon wanda aka kunna nan da nan bayan maganin na baka na iya taimakawa hana wuce haɗari na kamuwa da kwayar moxifloxacin in an sami ƙarin yawan zubar jini.

Umarni na musamman

A wasu halaye, bayan amfani da farko na miyagun ƙwayoyi, rashin lafiyar jiki da halayen rashin lafiyan na iya haɓaka, wanda ya kamata a sanar da likita nan da nan. Da wuya, koda bayan amfani da farko na miyagun ƙwayoyi, halayen anaphylactic zai iya ci gaba zuwa rawar jiki anaphylactic-barazanar rayuwa. A cikin waɗannan halayen, ya kamata a dakatar da jiyya tare da Moflaxia kuma dole ne a fara matakan warkewa (gami da anti-shock) nan da nan.

Lokacin amfani da miyagun ƙwayoyi Moflaxia a wasu marasa lafiya, ana iya fadada fadada ta tsakanin Qt. Ya kamata a yi amfani da Moflaxia tare da taka tsantsan a cikin mata da tsofaffi marasa lafiya. Tunda mata suna da tsawon lokacin QT idan aka kwatanta da maza, za su iya zama mai hankali ga magungunan da ke tsawaita wannan tazara. Tsofaffi marasa lafiya kuma sun fi saurin kamuwa da magungunan da ke shafar tazara ta QT.

Tsawaita tazara na QT yana da alaƙa da haɓakar haɗarin arrhythmias, ciki har da polymorphic ventricular tachycardia.

Matsakaicin tsawan tsakaitaccen tsaka-tsakin QT na iya ƙaruwa tare da haɓaka cikin moxifloxacin a cikin jini, saboda haka, shawarar da aka ba da shawarar kada ta wuce. Koyaya, a cikin marasa lafiya da ciwon huhu, ba a lura da daidaituwa tsakanin haɗuwa da moxifloxacin a cikin jini da kuma tsawaita tazara QT. Babu wani daga cikin marasa lafiya 9,000 da aka bi da moxifloxacin da ke da rikice-rikice na zuciya ko jijiyoyi masu rauni waɗanda ke da alaƙa da tsawan tsaka-tsakin QT. Ta hanyar amfani da miyagun ƙwayoyi na Moflaxia, haɗarin haɓaka ƙwayoyin ventricular arrhythmias a cikin marasa lafiya tare da yanayin tsinkayar arrhythmias na iya ƙaruwa.

A wannan batun, da miyagun ƙwayoyi Moflaxia ne contraindicated idan akwai canje-canje a cikin electrophysiological sigogi na zuciya, aka bayyana a tsawanta na QT tazara (na haihuwa ko samu rubuce rubuce tsawo na QT tazara), electrolyte hargitsi, musamman a ba-gyara hypokalemia, asibiti mai mahimmanci bradycardia raguwa, asibiti ta rage karfin jini , kasancewar a tarihin rikice rikice, tare da alamu na asibiti, a hade tare da wasu magunguna, yayuschimi tazara QT (cm. "hulda").

Ya kamata a yi amfani da miyagun ƙwayoyi Moflaxia tare da taka tsantsan:

- a cikin marasa lafiya da ke cikin yiwuwar kamuwa da cuta, irin su ischemia mai girma da kuma kamuwa da zuciya,

- a cikin marasa lafiya da ke fama da cutar cirrhosis (tunda a cikin wannan rukuni na marasa lafiya, haɗarin haɓakar haɓaka tazara na QT ba zai yiwu a yanke hukunci ba).

Lokacin shan moxifloxacin, lokuta na cikakke cututtukan hepatitis da aka ruwaito, yiwuwar haifar da ci gaban hanta (ciki har da mummunan lamuni) (duba “Abubuwan sakamako”). Yakamata a sanar da mara lafiyar cewa idan akwai alamun alamun gazawar hanta, ya zama dole a nemi likita kafin a ci gaba da magani da Moflaxia.

Lokacin shan moxifloxacin, lokuta na ci gaba da raunuka fata raunuka, irin su cututtukan Stevens-Johnson ko mai guba da keɓaɓɓen ƙwayar cuta, an bayar da rahoton (duba “Side effects”). Yakamata a sanar da mara lafiya cewa idan akwai alamun fata ko membranes na mucous, ya zama dole a nemi likita kafin a ci gaba da magani da Moflaxia.

Yin amfani da magungunan quinolone yana da alaƙa da haɗarin yiwuwar kamuwa da cuta. Ya kamata a yi amfani da miyagun ƙwayoyi Moflaxia tare da taka tsantsan a cikin marasa lafiya da cututtuka na tsarin juyayi na tsakiya kuma tare da rikice-rikice na tsarin juyayi na tsakiya, yana haifar da tashin hankali ko saukar da ƙarancin aiki mai ƙima.

Yin amfani da magungunan hana ƙwayoyin cuta na kwayan cuta, ciki har da miyagun ƙwayoyi na Moflaxia, ana haɗuwa da haɗarin cututtukan ƙwayar cuta na pseudomembranous colitis. Yakamata a gano wannan cutar a cikin marassa lafiya wadanda suka kamu da zazzabin cizon sauro yayin magani tare da Moflaxia. A wannan yanayin, yakamata a yi maganin abin da ya dace. Magungunan da ke hana motsin hanji suna tazara cikin haɓakar zazzabin cizon sauro.

Ya kamata a yi amfani da Moflaxia tare da taka tsantsan a cikin marasa lafiya tare da myasthenia gravis. gravis dangane da yiwuwar fashewar cutar.

A bango na maganin quinolone, ciki har da moxifloxacin, haɓakar tendonitis da rushewar jijiya mai yiwuwa ne, musamman a cikin tsofaffi marasa lafiya da marasa lafiya da ke karɓar corticosteroids. Kwayoyin da suka faru a cikin 'yan watanni bayan kammala magani an bayyana su. A farkon alamun farko (jin zafi ko kumburi a wurin rauni), ya kamata a dakatar da miyagun ƙwayoyi na Moflaxia kuma an sauƙaƙe ƙafar da abin ya shafa.

Lokacin amfani da quinolones, ana lura da halayen kulawa. Koyaya, yayin ingantaccen nazari na asibiti da na gwaji, kazalika da amfani da moxifloxacin a cikin aikin asibiti, ba a lura da halayen daukar hoto ba. Koyaya, marasa lafiya da ke karɓar Moflaxia ya kamata su guji haɗuwa da hasken rana kai tsaye da kuma ƙarfin UV.

Yin amfani da miyagun ƙwayoyi Moflaxia a cikin nau'ikan Allunan don maganin baka ba da shawarar a cikin marasa lafiya da cututtukan cututtuka masu rikitarwa na gabobin pelvic (alal misali, hade da tubo-ovarian ko ƙashin ƙashin ƙugu).

Yin amfani da moxifloxacin don maganin cututtukan da ke haifar da damuwa ba da shawarar ba. Amintakarwatsayayya da methicillin. Game da wadanda ake zargi ko tabbatar da kamuwa da cuta ta hanyar MRSA, yakamata a yi amfani da magungunan antibacterial don maganin (duba. Pharmacodynamics). Ofarfin moxifloxacin don hana haɓakar mycobacteria na iya haifar da hulɗa a ƙarƙashin yanayi a cikin vitro moxifloxacin tare da gwaji don Mycobacterium spp., wanda ke haifar da sakamako mara kyau na karya yayin nazarin samfuran marasa lafiya waɗanda aka bi da Moflaxia yayin wannan lokacin.

A cikin marasa lafiya waɗanda aka bi da su tare da quinolones, ciki har da moxifloxacin, an bayyana lokuta na firikwensin ko sensorimotor polyneuropathy, wanda ke haifar da paresthesia, hypesthesia, dysesthesia, ko rauni. Ya kamata a faɗakar da marasa lafiyar da ke fama da Moflaxia game da buƙatar yin tuntuɓar likita nan da nan kafin a ci gaba da magani idan akwai alamun cututtukan neuropathy, ciki har da jin zafi, ƙonawa, tinging, ƙamus ko rauni (duba "sakamako masu illa"). Abubuwan da ke tattare da tunanin mutum na iya faruwa ko da bayan fara amfani da fluoroquinolones, gami da moxifloxacin. A lokuta da dama sosai, rashin kwanciyar hankali ko halayen tunani suna ci gaba da faruwa ga tunanin mutum ya kashe kansa, harma da cutar da kai, gami da kokarin kashe kansa (duba “Abubuwan sakamako”). Idan irin waɗannan halayen suka ci gaba a cikin marasa lafiya, ya kamata a dakatar da miyagun ƙwayoyi Moflaxia kuma dole a dauki matakan da suka dace. Dole ne a yi taka tsantsan lokacin amfani da miyagun ƙwayoyi Moflaxia a cikin marasa lafiya tare da tarihin psychosis da cututtukan kwakwalwa.

Sakamakon yaduwa da karuwa a cikin cututtukan da ke haifar da cututtukan fluoroquinolone Neisseria gonorrhoeae, a cikin lura da marasa lafiya da cututtukan kumburi na gabobin pelvic, moxifloxacin monotherapy bai kamata a aiwatar da su ba, sai dai idan kasancewar ƙwayoyin cuta mai tsafta N. gonorrhoeae cire.Idan ba zai yiwu a ware bayyanar cututtukan fluoroquinolone ba N. gonorrhoeae, wajibi ne don warware batun ingara maganin tausa tare da moxifloxacin tare da ƙwayoyin rigakafin da suka dace da ke aiki da N. gonorrhoeae (misali cephalosporin).

Kamar yadda yake tare da sauran fluoroquinolones, yin amfani da miyagun ƙwayoyi Moflaxia ya nuna canji a cikin taro na glucose a cikin jini, ciki har da hypo- da hyperglycemia. A lokacin jiyya tare da moxifloxacin, dysglycemia ya faru ne a cikin tsofaffi marasa lafiya da ciwon sukari mellitus suna karbar concomitant far tare da hypoglycemic magunguna don maganin baka (misali, shirye-shiryen sulfonylurea) ko insulin. Lokacin da kake kulawa da marasa lafiya da ciwon sukari, ana ba da shawarar kulawa da hankali akan ƙwayar glucose jini (duba "Tasirin sakamako").

Tasiri kan ikon aiwatar da abubuwa masu haɗari waɗanda ke buƙatar kulawa ta musamman da kuma halayen gaggawa (alal misali, tuki, aiki tare da injin motsi). Fluoroquinolones, ciki har da moxifloxacin, zai iya lalata ikon marasa lafiya don fitar da mota da shiga cikin wasu ayyukan masu haɗari waɗanda ke buƙatar ƙara kulawa da saurin halayen psychomotor sakamakon tasirin tsarin juyayi na tsakiya da rauni na gani.

Fom ɗin saki

Allunan da aka saka fim, 400 MG. 5, 7 ko allunan 10 a cikin kumburi daga kayan hade OPA / Al / PVC - aluminium. 1 ko 2 bl. (Allunan 5), ko 1 bl. (7 Allunan), ko 1 bl. (Allunan 10) ana sanya su a cikin kwali.

Don asibitoci: 5, 10, 14, 16 ko 20 bl. (5 Allunan) ko 10 bl. (Allunan 7), ko 5, 7, 8, ko 10 bl. (Allunan 10) ana sanya su a cikin kwali.

Tsari sashi:

Allunan mai rufe fim

1 kwamfutar hannu mai rufe jiki ya ƙunshi:

Moxifloxacin hydrochloride 454.75 mg, daidai yake da moxifloxacin 400.00 mg

Fitowa: microcrystalline cellulose 186.05 mg, croscarmellose sodium 32,00 mg, magnesium stearate 6.00 mg

Shell fim: hypromellose 12.60 mg, macrogol-4000 4.20 mg, titanium dioxide (E171) 3.78 mg, iron dye oxide ja (E172) 0.42 mg

Capsule-dimbin yawa, allunan biconvex, mai rufe fim, ruwan hoda mai duhu.

Raunin ɓangaren giciye: haske mai launin rawaya mai haske tare da fim ɗin launuka masu ruwan hoda mai duhu

Kayan magunguna

Pharmacodynamics

Moxifloxacin wani kwayar cuta ce ta kwayan cuta mai kashe kwayoyin cuta, 8-methoxy fluoroquinolone.

Sakamakon ƙwayar cuta na moxifloxacin yana faruwa ne sakamakon hana topoisomerases na ƙwayoyin cuta na II da IV, wanda ke haifar da rushewar hanyoyin aiwatar da kwafi, gyara da kuma fassarar kwayar halittar halittar halittar ƙwararrun ƙwayoyin cuta ta DNA kuma, sakamakon hakan, ga mutuwar ƙwayoyin ƙwayoyin cuta.

Imumaramar maida hankali na ƙwayoyin cuta na moxifloxacin duk ana iya kwatanta su da ƙananan ƙananan ƙwayoyin inhibitory.

Hanyoyin da ke haifar da ci gaban juriya ga maganin penicillins, cephalosporins, aminoglycosides, macrolides da tetracyclines ba su shafar ayyukan hana ƙwayoyin cuta na moxifloxacin.

Babu juriya tsakanin-wadannan kungiyoyi na kwayoyi masu kashe kwayoyin cuta da moxifloxacin. Ya zuwa yanzu, har ila yau, ba a sami maganganun juriya na plasmid ba. Matsayin gaba ɗaya na haɓakar juriya kaɗan ne (10 -7 -10 -10).

Moxifloxacin juriya yana tasowa ne sannu a hankali ta hanyar rikida abubuwa masu yawa. Maimaitawa na moxifloxacin zuwa microorganisms a cikin maida hankali a ƙasa da ƙaramin inhibitory maida hankali (MIC) yana haɗuwa tare da ƙaramin ƙaruwa a cikin MIC. Akwai lamunin giciye-tsayayya ga quinolones. Koda yake, wasu kwayoyin-gram-tabbatacce kuma anaerobic microorganisms masu tsayayya da sauran quinolones suna kula da moxifloxacin.

An kafa shine cewa ƙari na kungiyar methoxy a cikin matsayin C8 zuwa tsarin moxifloxacin kwayoyin ƙara motsi na moxifloxacin kuma yana rage haɓakar ƙwayoyin cuta masu ƙwayar cuta. Additionarin rukuni na bikcloamine a matsayi C7 yana hana haɓakar efflux mai aiki, hanyar juriya ga fluoroquinolones.

Moxifloxacin a cikin yanayi avitro aiki da yawa daga gram-korau da na gram-tabbatacce microorganisms, anaerobes, kwayoyin-acid-resistant kwayoyin cuta da-atomatik kamar Mycoplasmaspp..Chlamydiaspp.,Legionellaspp., kazalika da kwayoyi masu tsayayya ga maganin P-lactam da maganin macrolide.

Tasiri akan jikin microflora na hanji

A cikin binciken biyu da aka gudanar akan masu ba da agaji, an lura da canje-canje masu zuwa ga microflora na hanji bayan gudanar da maganin moxifloxacin. An lura da raguwa da yawa. Esherichiacoli,Bacillusspp.,Bacteroidesvulgatus,Enterococcusspp.,Klebsiellaspp., kazalika da anaerobes Bifidobacteriumspp.,Eubacteriumspp.,Karatocinspp. Waɗannan canje-canjen an sake juyawa cikin makonni biyu. Toxin Clostridiumyaduwa ba a gano ba.

Gwajin hankaliavitro

Kwayar kwayar cutar kwayar cuta ta moxifloxacin ta hada da wadannan abubuwan:

* Rashin hankali shine moxifloxacin an tabbatar dashi ta bayanan asibiti.

+ Ba'a bada shawarar amfani da miyagun ƙwayoyi na Moflaxia don magance cututtukan cututtukan da ke haifar da damuwa S.aureus, methicillin resistant (MRSA). Idan ana zargin ko cutar ta tabbatar da cutar MRSA, magani tare da magungunan kashe kansa da suka dace ya kamata a tsara.

Ga takamaiman nau'in, yaduwar karɓar juriya na iya bambanta ta yankin yanki da tsawon lokaci. Dangane da wannan, lokacin gwada gwajin ƙwayar damuwa, yana da kyau a sami bayanai na gida game da juriya, musamman ma don magance cututtukan cututtukan fata.

Idan a cikin marasa lafiya da ake kulawa da su a asibiti, darajar yankin a karkashin lokacin hada-hadar magunguna (AUC) / MHK9o ya wuce 125, kuma matsakaicin plasma maida hankali (Cmax) / MIC90 yana cikin kewayon 8-10, to wannan yana nufin asibiti haɓakawa. A cikin marasa lafiya, ƙimar waɗannan sigogi marasa galibi yawanci ƙasa ne: AUC / MHK90> 30-40.

Saki siffofin da abun da ke ciki

Akwai magungunan a cikin kwamfutar hannu. Tabletaya daga cikin kwamfutar hannu ya ƙunshi akalla 400 MG na babban sinadaran aiki - moxifloxacin hydrochloride. Bugu da ƙari, abun da ke cikin magungunan sun hada da macrogol, titanium dioxide, hypromellose, fenti. Allunan suna da siffar biconvex capsular. An rufe su da wani fim mai ruwan hoda. Allunan moflaxia suna kunshe cikin firiji na 5, 7 ko 10 inji. An saka blisters a cikin kwali na kwali. Magunguna a cikin hanyar samar da mafita don gudanarwar intramuscular da na ciki yana ciki.

Akwai magungunan a cikin kwamfutar hannu.

Aikin magunguna

Aiki mai aiki na Moflaxia ya kasance ga rukuni na fluoroquinolones, saboda haka yana da tasirin antibacterial tasiri a cikin ɗimbin ƙwayoyin cututtukan ƙwayoyin cuta. Ayyukan miyagun ƙwayoyi ya kasance ne saboda yiwuwar hana abu mai aiki na shiri na topoisomerases na kwayan cuta na nau'ikan 2 da 4, sakamakon abin da kwayoyin cutar biosynthesis suka keta cikin sel na kwayoyin cuta, wanda ke haifar da mutuwar ƙwayoyin cuta.

Aiki mai aiki na Moflaxia yana shafar duka ƙwayoyin-gram-tabbatacce kuma gram-negative microorganisms. Bugu da kari, miyagun ƙwayoyi suna da tasiri a cikin siffofin da ake iya ɗauka na microflora na pathogenic.

Alamu don amfani

Ana iya tsara wannan maganin don manyan cututtuka da ke tattare da yanayin kamuwa da cuta, tare da kumburi mai zafi. Ana bada shawara don amfani da maganin kawai idan mai haƙuri ya tabbatar da kasancewar microflora mai hankali ga Moflaxia. Alamu don amfani da maganin na iya zama sinusitis mai raɗaɗi.

An ba da shawarar yin amfani da maganin don yin amfani da shi a cikin yanayin cututtukan mashako na kullum. An ba da izinin alƙawarin Moflaxia don magance cututtukan fata na cututtukan fata, ci gaba ba tare da bayyanar alamun kumburi ba. Amfani da Moflaxia don dalilai na warkewa yana da gaskiya cikin lura da cutar huhun da al’umma ta samu, gami da cututtukan da ke haifar da ƙwayoyin cuta.

Ana nuna Moflakia don sinusitis.
Masana sun ba da shawarar yin amfani da magani don maganin mashako na kullum.
An ba da izinin alƙawarin Moflaxia don magance cututtukan fata na yanayin cutar.
A matsayin wani ɓangare na ingantaccen magani, ana bada shawarar wannan maganin don sinusitis.
Yin amfani da Moflaxia ya barata a lura da cututtukan kumburi da tsarin haihuwa.

A matsayin wani ɓangare na ingantaccen magani, ana bada shawarar wannan maganin don sinusitis. Ana iya amfani da ƙarancin Moflaxia don rikitarwa na cututtukan fata. Tare da wannan magani, zaku iya kula da ƙafar mai ciwon sukari, mai rikitarwa ta hanyar haɗarin kamuwa da cuta na sakandare.

Alamu don amfanin miyagun ƙwayoyi sune raunin ciki da ciki da rikitarwa na ciki-ciki. Yin amfani da Moflaxia ya barata a lura da cututtukan kumburi da tsarin haihuwa. Bugu da kari, ana iya amfani da maganin don prostatitis na yanayin cutar.

Tare da kulawa

Tare da taka tsantsan, ana ba da wannan magani ga marasa lafiya da ke fama da cutar ta CNS, tare da bayyanar cututtukan abubuwa. Ana buƙatar saka idanu na musamman game da yanayin mai haƙuri ta ƙwararrun likitoci idan mai haƙuri yana da raunin hankali.

Bugu da kari, yakamata a yi amfani da maganin tare da taka tsantsan wajen lura da marasa lafiya da ke fama da cututtukan zuciya da samun tarihin kamawar zuciya. Dole ne a gudanar da maganin moflaxia ga marasa lafiya da ke fama da cutar cirrhosis a ƙarƙashin kulawar kwararrun. Wannan rukunin marasa lafiya yana da haɗarin haɓaka sakamako na sakamako masu illa da inganta yanayin yanayin ilimin halin da ake ciki.

Tare da taka tsantsan, ana ba da wannan maganin ga marasa lafiya da ke fama da cutar ta CNS.

Yadda ake ɗaukar Moflaxia

Wannan magani an yi shi ne don amfanin ciki. A cikin lura da cututtukan da ke haifar da ƙwayoyin cuta waɗanda ƙwayoyin cuta ke kula da aikin Moflaxia mai aiki, wannan magani ya kamata a sha shi a cikin kashi 400 MG (1 kwamfutar hannu 1) sau ɗaya a rana. Ya kamata a hadiye kwamfutar hannu ba tare da tauna ba, kuma a tabbatar a sha shi da ruwa. Don cimma sakamako na warkewa a cikin mafi yawan cututtukan cututtukan, shan magani don kwanaki 5-7 ya isa. Tare da rikitarwa masu rikitarwa na fata da rami na ciki, hanyar kulawa na iya zama daga kwanaki 14 zuwa 21.

Shan maganin don ciwon sukari

An tsara wa marasa lafiya da ciwon sukari mellitus magani a cikin kashi na 400 MG kowace rana, amma ana buƙatar saka idanu sosai akan matakan glucose na jini.

Marasa lafiya da ciwon sukari, an sanya maganin a cikin sashi na 400 MG kowace rana.

Gastrointestinal fili

Amincewa da Moflaxia yana da tasirin sakamako kai tsaye a cikin narkewar abinci kuma yana haifar da canji a cikin microflora na hanji, wanda ke kara haɗarin sakamako masu illa daga tsarin narkewa. Dangane da bayanan asibiti, yawancin lokuta marasa lafiya bayan shan Moflaxia suna da korafi na tashin zuciya, rikicewar alamomin ciki da ciwon ciki. Arancin lokaci tare da maganin Moflaxia, ana lura da raguwar ci. Bugu da kari, haɓakar flatulence da dyspepsia mai yiwuwa ne. A cikin lokuta masu wuya, stomatitis, gastro na erosive, dysphagia, da colitis suna bayyana yayin jiyya tare da miyagun ƙwayoyi.

Moflaxia na iya haifar da rikicewar rashin jijiya.
A wasu halayen, anorexia na iya faruwa.
Yayin shan maganin, mai haƙuri na iya damuwa da tashin zuciya.
A cikin halayen da ba a sani ba, miyagun ƙwayoyi na iya haifar da stomatitis.

Tsarin juyayi na tsakiya

A cikin lura da Moflaxia, bayyanar raunin hankali, wanda aka bayyana ta ƙara yawan tashin hankali da damuwa, mai yiwuwa ne. Wasu marasa lafiya suna fuskantar bacin rai da zafin rai. Hallucinations da damuwa na bacci mai yiwuwa ne. Tare da maganin Moflaxia, tsananin farji da ciwon kai na iya faruwa. Wataƙila rikice-rikice a cikin dandano na dandano da ƙanshi, dysesthesia, paresthesia da polyneuropathy na waje.

Daga tsarin urinary

Abubuwan da ke haifar da sakamako daga amfani da Moflaxia daga tsarin jijiya suna da wuya. Maiyuwa akwai alamun lalacewa aiki. Rashin ƙarfi na iya faruwa.

Moflaxia na iya haifar da rashin ƙarfi da bacin rai.
A wasu halaye, marasa lafiya suna da matsala bacci.
A miyagun ƙwayoyi na iya haifar da dizziness da migraines.
Moflaxia na iya haifar da nessarancin numfashi da kuma tashin hankalin asma.
Tsarin urinary na iya damuwa da gazawar koda.
Yayin shan kwayoyi, dandano da kamshi masu tayar da hankali ba su yanke hukunci ba.

Daga tsarin zuciya

Lokacin amfani da Moflaxia, tachycardia yana kai hare-hare, tsalle-tsalle cikin karfin jini da fitsarin da ya faru sakamakon cin zarafin tsarin zuciya na iya faruwa.

Lokacin amfani da Moflaxia, tashin hankali na tachycardia da tsalle-tsalle cikin karfin jini na iya faruwa.

Daga musculoskeletal da nama mai haɗuwa

A kan tushen ɗaukar maganin, bayyanar myalgia da arthralgia yana yiwuwa. A cikin wasu marasa lafiya, an lura da ƙara sautin tsoka da jijiyar wuya. Tendon katsewa da haɓakar cututtukan arthritis ba su da tabbas.

A cikin lura da Moflaxia, halayen rashin lafiyan na iya faruwa, wanda aka bayyana azaman fatar fata, itching, da urticaria. A cikin halayen da ba a san su ba, ana iya yin amfani da angioedema da anaphylaxis.

Tasiri kan ikon sarrafa abubuwan inji

Lokacin da ake cikin jiyya tare da Moflaxia, ya kamata ka ƙi tuki mota kuma ka kula da sauran sarkoki.

Lokacin da ake cikin jiyya tare da Moflaxia, ya kamata ka ƙi hawa mota.

Aikace-aikace don aikin hanta mai rauni

A cikin yanayin rashin aikin hanta da gazawar hanta, ana iya amfani da Moflaxia don magance cututtuka, amma marasa lafiya da ke da irin wannan cututtukan suna buƙatar kulawa ta musamman ta ƙwararrun likitoci.

Tare da aikin hanta mai rauni da kuma kasancewar rashin hanta, ana iya amfani da Moflaxia don magance cututtukan cututtuka.

Abun dacewa

Lokacin da ake shan magani na rigakafi tare da Moflaxia, dole ne ku ƙi shan barasa.

Akwai kwayoyi da yawa waɗanda zasu iya yin maye gurbin Moflaxia, gami da:

Avelox shine ɗayan analogues na Moflaxia.

Nazarin Moflaxia

Irina, 32 years old, Chelyabinsk

Ina amfani da Moflaxia tare da ɓacin rai na mashako. Wannan cuta cuta ce a cikin tsari kuma kowane watanni 2-3 yana bayyana ta bayyanar cututtuka. Ina amfani da Moflaxia na tsawon kwanaki 2-3 kuma dukkan alamu na da sauri kauda kai. Magungunan ba wai kawai yana kawar da alamun cutar da sauri ba, amma kuma ba ya haifar mini da wata illa. Ina shirin ci gaba da amfani da wannan magani.

Maxim, dan shekara 34, Moscow

Kimanin shekara guda da suka wuce, ruwan sama ya faɗi a cikin ruwan sama kuma lokacin da ya isa gida ya yi kwanciya, ba ya bushe gashinsa gaba ɗaya. Da safe na ji matsin lamba a idanu da kuma ciwon kai mai tsanani. Abubuwan da aka fahimta ba su iya jurewa ba, don haka nan da nan na je wurin likitan da ya binciko mini cutar sankara. Likita ya ba da maganin Moflaxia. Anyi amfani da wannan magani na makonni 2. Na ji ci gaba a rana ta biyu, amma na yanke shawara in ɗauki hanya zuwa ƙarshen, saboda tsoron rikice-rikice. Magungunan yana ba da sakamako mai kyau.

Kristina, yar shekara 24, Sochi

Kimanin shekara guda da suka wuce ta kamu da mura. Da farko, duk da zazzabi, ban kula da shi ba, amma sai yanayin ya fara tabarbarewa, don haka dole ne in kira motar asibiti. Asibitin ya bayyana ciwon huhu. A kan shawarar likita, ta fara shan Moflaxia. Bayan fara maganin, sai na sami ɗan tashin zuciya. Magungunan sun ƙi shan shi kuma bayan 'yan kwanaki sai na ji daɗin da kyau. Ta yi wata yar jinya, wacce ta dauki tsawon kwanaki 14, kuma ta yi farin ciki da sakamakon.

Igor, dan shekara 47, Saint Petersburg

Na sha wahala daga ciwon sukari mellitus kuma kodayake na bi tsarin abinci da kyau kuma na kula da matakin sukari, ciwon mara ya bayyana a ƙafafuna, wanda ya haɓaka cikin sauri kuma yana narkarda shi. Kamar yadda likita ya umurce shi, ya yi amfani da Moflaxia a matsayin wani ɓangare na ƙwaƙƙwarar magani. Kayan aiki ya taimaka da yawa. Raunin ya daina feshin kwanaki da yawa yana fara warkewa. Na yi amfani da kwayoyin don kwanaki 14. Ba'a lura da wani sakamako masu illa ba.

Analogs a cikin kayan haɗin da nuni don amfani

Jerin da aka bayar na magungunan analogues na miyagun ƙwayoyi, wanda ke nuna Madadin Moflaxia, ya fi dacewa saboda suna da tsari iri ɗaya na abubuwa masu aiki da daidaituwa bisa ga nuni don amfani

Abun daban-daban, na iya daidaituwa cikin nuni da hanyar aikace-aikace

Yaya za a sami analog mai rahusa na magani mai tsada?

Don neman analog mai rahusawa ga magani, jana'iza ko alaƙa, da farko muna bada shawara a kula da abun da ke ciki, wato ga abubuwa masu aiki iri ɗaya da alamomi don amfani. Abubuwa masu aiki iri ɗaya na ƙwayoyi zasu nuna cewa maganin yana da alaƙa tare da miyagun ƙwayoyi, daidai da magunguna ko madadin magunguna. Koyaya, kar ka manta game da abubuwanda suka lalace na irin kwayoyi, wanda zai iya shafar aminci da tasiri. Kada ku manta game da umarnin likitoci, magani na kai na iya cutar da lafiyar ku, don haka koyaushe tuntuɓi likitanku kafin amfani da kowane magani.

Koyarwar Moflaxia

INGANTA
a kan amfani da miyagun ƙwayoyi
Moflaxia

Abu mai aiki
Moxifloxacin

Tsari sashi:
Allunan mai rufe fim.

Abun ciki:
1 kwamfutar hannu mai rufe jiki ya ƙunshi:
Kernel:
abu mai aiki: moxifloxacin hydrochloride 454.75 mg, kwatankwacin moxifloxacin 400,00 mg,
magabata: microcrystalline cellulose 186.05 mg, croscarmellose sodium 32,00 mg, magnesium stearate 6.00 mg,
Shean fim: hypromellose 12.60 mg, macrogol-4000 4.20 mg, titanium dioxide (E171) 3.78 mg, fenti baƙin ƙarfe oxide ja (E172) 0.42 mg.

Bayanin:
Capsule-dimbin yawa, allunan biconvex, mai rufe fim, ruwan hoda mai duhu.
Raunin ɓangaren giciye: haske mai launin rawaya mai haske tare da fim ɗin launuka masu ruwan hoda mai duhu

Rukunin Magunguna:
wakilin maganin rigakafi - fluoroquinolone

ICD-10:
X.J00-J06.J01 Manyan sinusitis
X.J10-J18.J13 ciwon huhu na huhu na huhu
X.J10-J18.J14 Cutar huhu da ke haifar da cutar Haemophilus tare da guntuwar Afanasyev-Pfeiffer
X.J10-J18.J15 Kwayar cutar huhu, ba a wani wuri dabam ba
X.J10-J18.J15.0 Klebsiella cutar huhu da huhu
X.J10-J18.J15.7 ciwon huhu ya haifar da ƙwayar cutar huhu ta Mycoplasma
X.J10-J18.J16.0 Chlamydia ciwon huhu
X.J10-J18.J16.8 Cutar huhu ta haifar da wasu ƙayyadaddun masu kamuwa da cuta
X.J20-J22.J20 Annobar cutar sankarau
X.J20-J22.J20.1 Babban mashahuri saboda cutar Haemophilus tare da sandar Afanasyev-Pfeiffer
X.J20-J22.J20.2 Matsalar ƙwaƙwalwar fata saboda ƙwaƙwalwar ƙwayar cuta
X.J20-J22.J20.8 Babban mashako saboda wasu wakilai da aka ambata
X.J40-J47.J42 Raunin rashin lafiyan cuta, wanda ba a bayyana
XI.K65-K67.K65 Peritonitis
XII.L00-L08.L01 Impetigo
XII.L00-L08.L02 Rashin fata, tafasa da carbuncle
XII.L00-L08.L03 Phlegmon
XII.L00-L08.L08.0 Pyoderma
XII.L00-L08.L08.9 kamuwa da cuta na fata da ƙashin bayan katako, ba a tantance ba

ATX:
J.01.M.A.14 Moxifloxacin

Magunguna:
Hanyar aikin
Moxifloxacin wani kwayar cuta ce ta kwayan cuta mai kashe kwayoyin cuta, 8-methoxy fluoroquinolone.
Sakamakon ƙwayar cuta na moxifloxacin yana faruwa ne sakamakon hana topoisomerases na ƙwayoyin cuta na II da IV, wanda ke haifar da rushewar hanyoyin aiwatar da kwafi, gyara da kuma fassarar kwayar halittar halittar halittar ƙwararrun ƙwayoyin cuta ta DNA kuma, sakamakon hakan, ga mutuwar ƙwayoyin ƙwayoyin cuta.
Imumaramar maida hankali na ƙwayoyin cuta na moxifloxacin duk ana iya kwatanta su da ƙananan ƙananan ƙwayoyin inhibitory.
Hanyoyin tsayayya
Hanyoyin da ke haifar da ci gaban juriya ga maganin penicillins, cephalosporins, aminoglycosides, macrolides da tetracyclines ba su shafar ayyukan hana ƙwayoyin cuta na moxifloxacin.
Babu juriya tsakanin-wadannan kungiyoyi na kwayoyi masu kashe kwayoyin cuta da moxifloxacin. Ya zuwa yanzu, har ila yau, ba a sami maganganun juriya na plasmid ba. Matsakaicin ƙarfin haɓakar juriya kaɗan ne (10-7-10-10).
Moxifloxacin juriya yana tasowa ne sannu a hankali ta hanyar rikida abubuwa masu yawa. Maimaitawa na moxifloxacin zuwa microorganisms a cikin maida hankali a ƙasa da ƙaramin inhibitory maida hankali (MIC) yana haɗuwa tare da ƙaramin ƙaruwa a cikin MIC. Akwai lamunin giciye-tsayayya ga quinolones. Koda yake, wasu kwayoyin-gram-tabbatacce kuma anaerobic microorganisms masu tsayayya da sauran quinolones suna kula da moxifloxacin.
An kafa shine cewa ƙari na kungiyar methoxy a cikin matsayin C8 zuwa tsarin moxifloxacin kwayoyin ƙara motsi na moxifloxacin kuma yana rage haɓakar ƙwayoyin cuta masu ƙwayar cuta. Additionarin rukuni na bikcloamine a matsayi C7 yana hana haɓakar efflux mai aiki, hanyar juriya ga fluoroquinolones.
In vitro moxifloxacin yana aiki da dumbin-gram-korau da gram-tabbatacce microorganisms, anaerobes, acid da ke jure kwayoyin cuta da kwayoyin cuta irinsu Mycoplasma spp., Chlamydia spp., Legionella spp., Kazalika da kwayoyin dake jure maganin to-lactam da maganin macrolide.
Tasiri akan jikin microflora na hanji
A cikin binciken biyu da aka gudanar akan masu ba da agaji, an lura da canje-canje masu zuwa ga microflora na hanji bayan gudanar da maganin moxifloxacin. Decreasearin raguwa da yawa daga cikin abubuwan da aka tattara na Escherichia coli, Bacillus spp. Bacteroides vulgatus, Enterococcus spp., Klebsiella spp., Kazalika anaerobes Bifidobacterium spp., Eubacterium spp., Peptostreptococcus spp. Waɗannan canje-canjen an sake juyawa cikin makonni biyu. Clostridium yalwatuwa abinci mai guba ba a gano shi ba.

Pharmacokinetics:
Damuwa
Lokacin da ake gudanar da shi, moxifloxacin yana shan cikin sauri kuma kusan gaba daya. Cikakken bayanin bioavailability kusan kashi 91%.
Magungunan magani na moxifloxacin lokacin da aka karɓa a kashi 50 zuwa 1200 mg sau ɗaya, kazalika da 600 mg / rana tsawon kwana 10, layi ne. An cimma matsayin daidaituwa tsakanin kwanaki 3.
Bayan aikace-aikacen guda ɗaya na 400 MG na moxifloxacin Cmax a cikin plasma jini ana samunsa ne tsakanin awanni 0.5-4 kuma shine 3.1 mg / L Bayan sarrafawar bakin kwayar cuta na 400 mg na moxifloxacin sau ɗaya a rana, Cssmax da Cssmin (matsakaici da ƙananan daidaitawa) sune 3.2 mg / L da 0.6 mg / L, bi da bi.
Lokacin ɗaukar moxifloxacin tare da abinci, akwai ƙaramin haɓaka a cikin lokaci don isa zuwa Cmax (ta awanni 2) da ƙananan raguwa a Cmax (kusan kashi 16%), yayin da tsawon lokacin sha bai canza ba. Koyaya, waɗannan bayanan basu da dacewa a asibiti, kuma ana iya amfani da moxifloxacin ba tare da lamar lokacin cin abinci ba.
Rarraba
Moxifloxacin ana yin saurin yaduwa cikin kyallen da gabobin kuma yana danganta garkuwar jini na jini (akasarin albumin) kimanin kamar 45%. Thearar da rarraba ta kusan 2 l / kg.
Babban hadadden moxifloxacin, wanda ya wuce wadanda ke cikin plasma jini, an kirkireshi ne a cikin huhun huhu (hade da kwayar epithelial, alveolar macrophages), a cikin sinadaran paranasal (maxillary da ethmoid labyrinth), a cikin hanci na hanci, a cikin illar cutar kumburi (a cikin abinda ke cikin blisters na raunukan fata). ) A cikin ruwa mai tsaka-tsakin yanayi da na yau da kullun, ana tantance moxifloxacin ta hanyar kyauta, wacce ba ta da furotin, a inda ya fi girma a cikin jini. Bugu da kari, an gano manyan abubuwan da ake kira moxifloxacin a cikin kasusuwa na gabobin ciki, da ruwa na ciki, da gabobin mace.
Tsarin rayuwa
Moxifloxacin yana gudanar da aikin biotransformation na kashi na 2 kuma an cire shi daga jiki ta hanyar kodan, haka kuma ta cikin hanji, duka biyun kuma ba canzawa ba kuma yana aiki a cikin mahadi sulfo na aiki (M1) da glucuronides (M2). Moxifloxacin ba biotransformed din ta microsomal cytochrome P450 tsarin. Metabolites M1 da M2 suna nan a cikin jini na plasma a cikin abubuwan da ke ƙasa da ƙananan mahaifa. Dangane da sakamakon binciken kwaskwarima, an tabbatar da cewa wadannan metabolites ba su da mummunan tasiri ga jiki dangane da aminci da juriya.
Kiwo
Rabin rayuwar moxifloxacin shine kamar awanni 12. Matsakaicin cikakken yarda bayan gudanarwa a kashi na 400 MG shine 179-246 ml / min. Rashin izini shine 24-53 ml / min. Wannan yana nuni da sake dawo da tushen tubular m of moxifloxacin.
Matsakaicin adadin farawa da metabolites na kashi na biyu kusan kashi 96-98% ne, wanda ke nuna rashin isashin metabolism. Kimanin kashi 22% na kaso ɗaya (400 MG) ana jujjuya shi daga kodan, kusan 26% - ta cikin hanji.
Pharmacokinetics a cikin kungiyoyin haƙuri daban-daban
Zamani, jinsi da kabilanci
Binciken masana kan magunguna na moxifloxacin a cikin maza da mata sun bayyana bambance-bambance na 33% cikin sharuddan AUC da Cmax. Rashin moxifloxacin bai dogara da jinsi ba. Bambance-bambance a cikin AUC da Cmax sun kasance saboda bambance-bambance a cikin nauyi maimakon jinsi kuma ba a ɗaukar su da mahimmanci a asibiti.
Babu wani bambance-bambancen asibiti a cikin magungunan moxifloxacin a cikin marasa lafiya na kabilu daban-daban da shekaru daban-daban.
Yara
Ba a yi nazarin magungunan magungunan moxifloxacin a cikin yara ba.
Paarancin aiki na haya
Babu wasu canje-canje masu mahimmanci a cikin kantin magunguna na moxifloxacin a cikin marasa lafiya da ke fama da rauni na aikin renal (ciki har da marasa lafiya tare da keɓancewar creatinine (QC)) An gabatar da duk bayanan ne don dalilai na sanarwa kuma ba dalili bane don keɓaɓɓen magani ko maye gurbin magani.