NovoMix® 30 FlexPen® Insulin yana da kashi biyu

Abunda yake aiki: 1 ml na dakatarwa don allura ya ƙunshi 100 IU / ml na insulin aspart (rDNA) (insulin kashi 30 na narkewa da kashi 70% na insulin tare da protamine)

Alkalami guda 1 ya ƙunshi 3 ml, wanda yayi daidai da raka'a 300

Nawa 1 (OD) shine 6m na nmol ko 0.035 na babban insulin anhydrous aspart,

Abubuwan da suka haɗu: glycerin, phenol, metacresol, chloride zinc, sodium chloride, sodium phosphate, dihydrate, sulfate protamine, sodium hydroxide, acid diluted hydrochloric, ruwa don allura.

Kayan magunguna

NovoMix ® 30 FlexPen ® ragi ne na kashi biyu na dakatarwar insulin aspart (analog na gajeran aiki insulin insulin) tare da yin insulin din insulin tare da protamine (analog na matsakaici). Dakatarwar ya ƙunshi tsarin insulin na ɗan gajeren abu da matsakaita tsawon lokacin aiki a cikin rabo na 30/70. Tare da gabatarwar allurai iri daya, insulin aspart shine kayan kwalliyar insulin ga mutum.

Rage tasirin sukari shine inganta haɓaka glucose ta kyallen takarda bayan ɗaurin insulin ga masu karɓa da ƙwayoyin mai, da kuma hanawar sakin glucose daga hanta.

NovoMix ® 30 FlexPen ® fara aiwatar da mintuna 10-20 bayan an sha maganin. Matsakaicin sakamako yana haɓaka sa'o'i 1-4 bayan gudanarwa. Tsawon lokacin aiki har zuwa awanni 24.

A cikin binciken asibiti wanda ya kai watanni 3 kuma idan aka kwatanta da gudanarwar NovoMix ®30 FlexPen ® da insulin mutum na jini 30 kafin karin kumallo da abincin dare a cikin marasa lafiya da nau'in I da nau'in ciwon sukari II, an nuna cewa tare da gabatarwar NovoMix F 30 FlexPen ® glucose jini bayan abincin biyu (karin kumallo da abincin dare), ya ɗan ragu sosai idan aka kwatanta da aikin insulin na ɗan adam 30.

Lokacin gudanar da nazarin-meta, wanda ya hada da gwaji na asibiti 9 a cikin marasa lafiya tare da nau'in I da nau'in ciwon sukari na II, an lura cewa, idan aka kwatanta da insulin mutum na 30, yawan amfani da NovoMix before30 kafin karin kumallo da abincin dare yana haifar da mafi kyawun mafi kyawun postprandial sarrafa glucose na jini (bisa ga matsakaiciyar karuwa a cikin glucose na jini bayan karin kumallo, abincin rana da abincin dare).

Duk da gaskiyar cewa glucose mai azumi ya kasance mafi girma a cikin marasa lafiya da ke karɓar magani NovoMix ®30, matakin glycosylated haemoglobin, alama ce ta jimlar sarrafa glycemic, iri ɗaya ce.

A cikin nazarin asibiti, marasa lafiya da ke dauke da nau'in ciwon sukari na II (mutane 341), waɗanda aka rarrabu cikin rukuni bisa ga ka'idodin bazuwar, sun karɓi NovoMix ® 30 ko NovoMix ® 30 a hade tare da metformin ko metformin tare da sulfonylureas. Bayan makonni 16 na jiyya, haɗuwa da HbA 1c a cikin marasa lafiya da ke karɓar NovoMix ® 30 da metformin ko metformin da sulfonylurea iri ɗaya ne. A cikin wannan binciken, a cikin 57% na marasa lafiya, yawan tattarawar HbA 1c ya fi 9% girma. A cikin waɗannan marasa lafiya, lokacin da suke lura da NovoMix ® 30 da metformin, raguwa a matakin HbA 1c ya fi muhimmanci fiye da haɗuwa da metformin da sulfonylurea.

A cikin nazarin nau'ikan masu ciwon sukari na nau'in II, wanda sarrafa glycemic ta amfani da magungunan maganin hypoglycemic na baki kawai ba shi da inganci, an bi da su tare da gudanarwa na NovoMix 30 sau biyu (marasa lafiya 117) ko sau ɗaya-kowace rana na insulin glargine (marasa lafiya 116). Bayan makonni 28 na jiyya, NovoMix â 30 tare da zaɓin kashi, matakin HbA 1C ya ragu da 2.8% (matsakaicin darajar HbA 1C lokacin da aka haɗa shi a cikin binciken = 9.7%). A lokacin jiyya tare da NovoMix â 30, 66% na marasa lafiya sun isa matakan HbA 1C a ƙasa da 7%, kuma 42% sun kai marasa lafiya ƙasa da 6.5%, yayin da ake buƙatar ƙwayar cutar plasma glucose ya ragu da kimanin 7 mmol / L (daga 14.0 mmol / l kafin jiyya har zuwa 7.1 mmol / l).

Lokacin gudanar da nazarin-meta a cikin marasa lafiya da ke dauke da ciwon sukari na II, an lura cewa tare da NovoMix® 30 haɗarin haɓakar haɓakawa da daddare da mummunan hypoglycemia an rage shi idan aka kwatanta da insulin mutum na biphasic 30. A lokaci guda, haɗarin cututtukan hawan jini a cikin rana ya kasance mafi girma a cikin marasa lafiya da ke karɓar NovoMix ® 30.

Yara da matasa. Nazarin mako-mako 16 wanda aka gudanar akan marassa lafiya 167 masu shekaru 10-18 idan aka kwatanta tasirin ci gaba da sarrafa glycemic iko ta hanyar sarrafa NovoMix 30 tare da abinci ta amfani da insulin / biphasic na mutum 30 tare da abinci tare da insulin NPH kafin lokacin bacci. Duk tsawon lokacin binciken a cikin rukunin biyun, maida hankali na HbA 1C ya kasance a matakin da aka haɗa cikin binciken, ba tare da wani bambance-bambance a cikin abin da ya faru tsakanin tsokawar jini tsakanin NovoMix 30 da insulin na ɗan adam 30.

A cikin binciken kashi-biyu makafi mai zurfi (12 makonni ga kowane darasi) wanda aka gudanar akan karamin rukuni na yara (mutane 54.) Lokacin da shekaru 6-12 ke ciki, karuwar adadin abubuwan da ke haifar da rashin daidaituwa da hawan glucose ya kasance ilimin kididdiga sosai idan aka kula da shi da NovoMix â 30 idan aka kwatanta da insulin na mutum inuwa 30. Matsakaicin HbA 1C a ƙarshen lokacin kulawa ya kasance ƙasa kaɗan a cikin rukunin da ke karɓar insulin na mutum kamar 30 fiye da ƙungiyar da ke karɓar NovoMix â 30.

Tsofaffi. Ba a yi nazarin magunguna na NovoMix â 30 a cikin tsofaffi marasa lafiya ba. Koyaya, an gudanar da bincike mai zurfin makafi sau biyu makafi wanda yayi kwatancen kan likitancetinetics da pharmacodynamics of insulin aspart da insulin dan adam mai narkewa a cikin 19 na marasa lafiya masu nau'in cutar sankara II masu shekaru 65-83 wadanda suke da shekaru 65-83 (yana nufin shekaru 70 kenan). Bambance-bambance na dangi a cikin magunguna (GIR max, AUC GIR, 0-120 min) bayan gudanar da insulin insulin ko insulin na mutane a cikin waɗannan marasa lafiya sun kasance iri ɗaya da na mutane masu lafiya ko marasa lafiya da ke fama da ciwon sukari.

A cikin insulin aspart, amino acid proline a matsayi 28 na sarkar ta sarkar insulin ana maye gurbinsu da aspartic acid, yana rage samuwar hexamers, kamar yadda aka fada a cikin shirye-shiryen insulin na mutum. A cikin lokaci mai narkewa na NovoMix 30, yawan insulin aspart shine 30% na duk insulin, yana shiga cikin jini daga ƙwayar subcutaneous da sauri fiye da insulin na insulin na insulin mutum. Kashi 70% da suka rage suna cikin nau'in kuzarin protamine-insulin aspart, ɗaukar tsawon rai wanda yake iri ɗaya ne da na NPH na ɗan adam. Matsakaicin yawan insulin a cikin ƙwayar jini bayan gabatarwar NovoMix 30 shine 50% mafi girma, kuma lokacin da za a isa shi shine rabin abin da insulin mutum na biphsic ke cikin 30. A cikin masu sa kai na lafiya, bayan subcutaneous management na NovoMix 30 a cikin kudi na 0.20 U / kg na nauyin jiki, matsakaicin taro magani na insulin aspart an samu shi ne bayan mintina 60, ya kasance 140 ± 32 pmol / L. Rabin rayuwar NovoMix ® 30 (t½), wanda ke nuna kimar adadin abubuwan da ake amfani da shi, ya kasance awanni 8-9. Matakan insulin insulin ya koma tushe 15 hours bayan gudanarwar subcutaneous. A cikin marasa lafiya da ke fama da ciwon sukari na 2, an fi mayar da hankali mafi yawa a cikin mintuna 95 bayan gudanarwa kuma ya kasance sama da tushen aƙalla awanni 14.

Tsofaffi. Ba a yi nazarin magunguna na NovoMix â 30 a cikin tsofaffi marasa lafiya ba. Koyaya, bambance-bambance na dangi a cikin dabi'un magunguna bayan gudanar da insulin aspart ko insulin na mutum a cikin marasa lafiya da ke fama da nau'in ciwon sukari na II II (shekaru 65-83, matsakaicin shekaru 70) daidai yake da a cikin mutane masu lafiya ko marasa lafiya da ciwon sukari na matasa. A cikin tsofaffi da tsofaffi marasa lafiya, yawan sha yana raguwa, kamar yadda aka tabbatar ta wani lokaci mai tsayi don isa mafi girman taro na insulin a cikin jini t max (82 min tare da kewayon cibiyar tsakanin 60-120 min). Ofimar C max iri ɗaya ce a cikin marasa lafiya da ke da nau'in ciwon sukari na 2 na wani ƙaramin shekaru kuma ɗan ƙasa kaɗan cikin marasa lafiya masu fama da ciwon sukari na 1.

Mai rauni na koda da hepatic aiki.

Ba a yi nazarin magunguna na NovoMix ® 30 ba a cikin marasa lafiya da ke fama da rauni ko aikin hepatic.

Yara da matasa. Ba a yi nazarin magunguna na NovoMix â 30 a cikin yara da matasa ba. Koyaya, a cikin yara (shekaru 6-12) da matasa (13-17 years) tare da nau'in ciwon sukari na 1, an yi nazarin kan magunguna da kuma magunguna na insulin insulin. Ya kasance cikin hanzari a cikin marasa lafiya na ɓangarorin biyu, yayin da ƙimar t ta iri ɗaya da na manya. A halin yanzu, darajar C max a cikin tsararraki daban-daban sun bambanta sosai, wanda ke nuna mahimmancin zaɓi ɗaya na alluran insulin allurai.

Bayanai na Tsare na Haraji.

Bayanai na asibiti wanda aka samo bisa tsarin binciken gargajiya akan harkar kimiyyar kiwon lafiya, yawan guba na magunguna, cututtukan fata da ƙoshin haihuwa, basu bayyana haɗarin musamman ga ɗan adam ba.

A cikin gwaje-gwaje na vitro, ciki har da ɗaure wa insulin da masu karɓa na IGF-1 da tasirin ci gaban kwayar halitta, insulin aspart ya nuna kamar insulin ɗan adam. Nazarin ya kuma nuna cewa rarrabuwar kawuna ga masu karɓar insulin don insulin aspart ɗin yayi daidai da insulin ɗan adam.

Form sashi

Dakatarwa don gudanarwar subcutaneous, 100 PIECES / ml

1 ml na dakatarwa ya ƙunshi

abu mai aiki - insulin kashi 100 U (3.5 MG) (mai narkewa 30% na jikin inzali da kashi 70% na insulin tare da protamine),

magabata: zinc, glycerol, phenol, metacresol, sodium hydrogen phosphate dihydrate, sodium chloride, protamine sulfate, hydrochloric acid, sodium hydroxide, ruwa don allura.

Wani farin fitarwa iri ɗaya, yayin ajiya, an daidaita shi cikin kamannin gaskiya, mara launi ko kusan madaukaki mara launi da farin farashi. Lokacin haɗuwa da abubuwan da ke cikin alkalami, dakatarwar da aka yi daidai ya kamata ya samar.

Sashi da gudanarwa

NovoMix® 30 FlexPen® an tsara shi kawai don subcutaneous management. Bai kamata a gudanar da NovoMix® 30 FlexPen admin ba tare da matsala ba, saboda wannan na iya haifar da matsanancin rashin ƙarfi na jini. Hakanan ya kamata a guji kula da aikin cikin zuciya na NovoMix® 30 FlexPen®. Karka yi amfani da NovoMix® 30 FlexPen® don jiko insulin na kashi-kashi (PPII) a cikin famfunan insulin.

Girman maganin yana maganin likita ne daban-daban a kowane yanayi, gwargwadon matakin glucose a cikin jini.

Marasa lafiya da ke fama da ciwon sukari na 2, NovoMix® 30 FlexPen® za a iya tsara su duka biyu azaman maganin monotherapy kuma a haɗe tare da magungunan maganganu na baka a cikin yanayin inda matakan glucose na jini ba su da isasshen tsari ta hanyar maganganu na maganin hypoglycemic kadai.

Ga marasa lafiya da ke fama da ciwon sukari na 2, shawarar da ke farawa ta NovoMix® 30 FlexPen® ita ce raka'a 6 da safe da kuma raka'a 6 da yamma (tare da karin kumallo da abincin dare, bi da bi). Hakanan an ba shi izinin ɗaukar raka'a 12 na NovoMix® 30 FlexPen® sau ɗaya a rana da yamma. A cikin maganar ta ƙarshe, duk da haka, bayan ɗaukar raka'a 30 na miyagun ƙwayoyi, ana bada shawara don canzawa zuwa shan NovoMix® 30 FlexPen® sau biyu a rana, rarraba kashi zuwa kashi daidai (tare da karin kumallo da abincin dare, bi da bi). Sauƙi mai lafiya zuwa ɗaukar NovoMix® 30 FlexPen® sau uku a rana mai yiwuwa ta hanyar rarraba kashi na safe zuwa sassa biyu daidai da ɗaukar waɗannan sassan biyu safe da yamma.

A cikin marasa lafiya da juriya na insulin (alal misali, saboda kiba), ana buƙatar ƙara yawan buƙatun insulin na yau da kullun, kuma a cikin marasa lafiya da keɓaɓɓen narkewa na insulin insulin, ana iya rage shi.

Ana ba da tebur mai zuwa don daidaitawar kashi:

Guban jini kafin abinci

Daidaitawaallurai NovoMix® 30

Ya kamata a gudanar da NovoMix® 30 FlexPen® nan da nan kafin abinci. Idan ya cancanta, ana iya sarrafa NovoMix® 30 FlexPen® jim kaɗan bayan fara cin abinci.

Zazzabi na insulin da ke cikin yakamata ya zama zazzabi a dakin.

NovoMix® 30 FlexPen® ya kamata a gudanar da subcutaneously a cinya ko bangon ciki. Idan ana son, ana iya gudanar da maganin a kafada ko gindi.

Wajibi ne a canza wurin allurar a cikin yankin na jiki don hana ci gaban lipodystrophy.

Kamar yadda yake tare da kowane shiri na insulin, tsawon lokacin aikin NovoMix® 30 FlexPen® ya dogara da kashi, wurin gudanarwa, tsananin zubar da jini, zafin jiki da kuma matakin motsa jiki. Ba a yi nazarin dogaro da ƙwayar NovoMix® 30 FlexPen® a kan allurar ba.

Hakanan ana iya buƙatar gyaran gyaran jiki idan mai haƙuri yana da cututtukan cututtukan da suka shafi kodan, hanta, nakasasshen aikin adrenal, glandar glandonto ko glandar glandar ku.

Buƙatar daidaitawa na iya faruwa yayin canzawar aiki na zahiri ko abincin da aka saba samu. Zai yiwu a buƙaci daidaitawa yayin canja wurin mai haƙuri daga nau'in insulin zuwa wani.

Tsofaffi da marassa lafiya

Ana iya amfani da NovoMix® 30 FlexPen® a cikin tsofaffi marasa lafiya, duk da haka, ƙwarewa tare da amfani dashi a hade tare da magungunan maganganu na bakin jini na marasa lafiya da suka girmi shekaru 75 yana iyakantacce.

A cikin marasa lafiya da keɓaɓɓen koda ko hepatic kasawa, ana buƙatar rage insulin.

A cikin tsofaffi marasa lafiya, ya zama dole don saka idanu matakan glucose na jini da daidaita sashin insulin insulin dangane da bayanan mutum.

Yara da matasa

Ana iya amfani da NovoMix® 30 FlexPen® don kula da yara da matasa a cikin shekaru 10 a cikin yanayin inda aka fi son yin amfani da insulin-hade-ins. Akwai ƙarancin bayanan asibiti game da yara masu shekaru 6 zuwa 9.

Kariya don amfani:

NovoMix® 30 FlexPen® da allura sune don amfanin kai kawai. Kar a cika kwantar da sikirin.

Ba za a iya amfani da NovoMix® 30 FlexPen after idan bayan hadawa ba ya zama fari da gajimare.

Wajibi ne a haɗu da dakatarwar NovoMix® 30 FlexPen® nan da nan kafin amfani. Karka yi amfani da NovoMix® 30 FlexPen® idan ya yi sanyi. Jefar da allura bayan kowace allura.

Side effects

Abubuwan da ba a sani ba sun lura a cikin marasa lafiya da ke amfani da NovoMix® 30 FlexPen® galibinsu sunada dogaro kuma sun kasance ne sakamakon tasirin magunguna na insulin.

Followinga'idodin da ke biyo baya na ƙayyadaddun halayen halayen da aka gano yayin gwaji na asibiti, waɗanda aka ɗauke su da alaƙa da amfani da NovoMix® 30 FlexPen®. An ƙaddara mitar kamar haka: sau da yawa (≥ 1/10), sau da yawa (≥ 1/100 zuwa

Nau'i na saki, marufi da abun da ke ciki

Dakatarwar don s / c gudanar da fararen launi, mai kama da juna (ba tare da lumps ba, flakes na iya bayyana a cikin samfurin), lokacin da aka rarrabe, delaminates, samar da farin farashi da launi mara haske ko kusan madaukaki mai launi, tare da motsawar hankali na hazo, dakatarwar sutura ya kamata ya samar.

Fitowa: glycerol - 16 mg, phenol - 1.5 mg, metacresol - 1.72 mg, zinc chloride - 19.6 μg, sinadarin sodium - 0.877 mg, sinadarin hydrogen phosphate mai narkewa - 1.25 mg, protamine sulfate

0.33 mg sodium hydroxide

2.2 MG, hydrochloric acid

1.7 MG, ruwa d / i - har zuwa 1 ml.

3 ml (300 PIECES) - katako (5) - blister (1) - fakitoci na kwali.

Aikin magunguna

Rashin dakatarwa sau biyu yana kunshe da cakudadden insulin analogues: mai narkewa a jikin insulin (30% na karancin insulin din insulin) da kuma lu'ulu'u na insulin protamine (kashi 70 na matsakaitan insulin).

Rage glucose na jini yana faruwa ne sakamakon haɓaka jigilar kwayar cutar cikin jikinta bayan ɗaurin insulin a cikin biphasic tare da masu karɓar insulin na tsoka da kyallen nama na adipose da kuma hana haɓakar glucose a lokaci guda.

Side sakamako

A wani ɓangare na rigakafi: akai-akai - urticaria, fatar fata, fatar jiki, da wuya - halayen anaphylactic.

Daga gefen metabolism da abinci mai gina jiki: sau da yawa - hypoglycemia.

Daga tsarin mai juyayi: da wuya - neuropathy na yanki (m zafi neuropathy).

Daga gefen gabobin hangen nesa: akai-akai - kurakurai masu narkewa, cututtukan fata masu ciwon sukari.

Daga fata da ƙananan kasusuwa: marasa jinkiri - lipodystrophy.

Janar halayen: ba tare da ɓata lokaci ba - edema.

Haihuwa da lactation

Kwarewar asibiti tare da daukar ciki yana da iyaka.

A cikin lokacin yiwuwar farawar ciki kuma a duk tsawon lokacinsa, Wajibi ne a lura da yanayin marasa lafiya da ciwon sukari mellitus da saka idanu akan yawan glucose a cikin jini. Bukatar insulin, a matsayin mai mulkin, yana raguwa a cikin farkon farkon kuma a hankali yana ƙaruwa a cikin watanni na biyu da na uku na ciki. Jim kaɗan bayan haihuwa, buƙatar insulin da sauri ya koma matakin da ya kasance kafin yin juna biyu.

Yayin shayarwa, ana iya amfani dashi ba tare da ƙuntatawa ba. Gudanar da insulin ga uwa mai shayarwa ba barazanar ga jariri ba. Koyaya, gyaran kashi na iya zama dole.

Yi amfani da yara

Ba'a ba da shawarar ga yara 'yan ƙasa da shekaru 6 ba, kamar yadda ba a gudanar da gwaji na asibiti ba.

Ana iya amfani dashi don kula da yara da matasa a cikin shekaru 10 a cikin halaye inda aka fi son amfani da insulin-hade-ins. Akwai iyakancewar bayanan asibiti don yara masu shekaru 6-9.

Umarni na musamman

Kafin doguwar tafiya wacce ta shafi canji a wasu lokutan, mai haƙuri ya kamata ya nemi shawara tare da likitan su, saboda canza yankin lokaci yana nufin cewa mara lafiya dole ne ya ci ya kuma ba da insulin a wani lokaci daban.

Insuarancin magunguna ko dakatar da magani, musamman tare da nau'in ciwon sukari na 1 na ciwon sukari, na iya haifar da haɓakar cututtukan hyperglycemia ko ketoacidosis na ciwon sukari. A matsayinka na mulkin, alamun farko na cututtukan hawan jini suna bayyana a hankali, a cikin sa'o'i da yawa ko kwanaki. Bayyanar cututtukan hyperglycemia shine jin ƙishirwa, karuwa a yawan fitsari da aka saki, tashin zuciya, amai, amai, ja da bushewar fata, bushewar baki, rashin cin abinci, da kuma bayyanar ƙamshin acetone a cikin iska mai ƙonewa. Ba tare da magani da ya dace ba, hyperglycemia a cikin marasa lafiya da ke dauke da ciwon sukari na 1 na iya haifar da ketoacidosis mai ciwon sukari, yanayin da ke da haɗari mai mutuwa.

Ski abinci ko kuma wani mummunan aiki na jiki wanda ba a shirya shi ba zai iya haifar da rashin lafiyar jiki. Hypoglycemia na iya haɓaka idan kashi na insulin yayi yawa sosai dangane da bukatun mai haƙuri.

Bayan ramawa game da metabolism na metabolism, alal misali, tare da ƙwaƙƙwaran ƙwaƙwalwar insulin, marasa lafiya na iya
alamu na alamu na abubuwanda ke haifar da canjin yanayin motsa jiki, wanda yakamata a sanar da marasa lafiya game da. Alamun gargaɗi na yau da kullun na iya ɓace tare da doguwar cutar sankara.

Cututtukan da ke haɗuwa, musamman masu kamuwa da cuta tare da zazzabi, yawanci suna ƙaruwa da buƙatar jikin mutum na insulin. Hakanan ana iya buƙatar gyaran gyaran jiki idan mai haƙuri yana da cututtukan cututtukan da suka shafi kodan, hanta, nakasasshen aikin adrenal, glandar glandonto ko glandar glandar ku.

Lokacin canza mai haƙuri zuwa wasu nau'in insulin, alamu na farkon abubuwan da ke haifar da tsotsar ƙin jini na iya canzawa ko zama mara ma'ana idan aka kwatanta da waɗanda suke amfani da nau'in insulin na baya.

Canja wurin wani mara lafiya zuwa wani sabon nau'in insulin ko kuma shirin insulin wani mai kamfanin dole ne a aiwatar dashi karkashin tsaftataccen aikin likita. Idan kun canza taro, nau'in, masana'anta da nau'in (insulin ɗan adam, analog na insulin mutum) na shirye-shiryen insulin da / ko hanyar samarwa, ana iya buƙatar canza sashi.

An bayar da rahoton maganganun ci gaban cututtukan zuciya na jijiya a cikin kula da marasa lafiya tare da thiazolidinediones a hade tare da shirye-shiryen insulin, musamman idan irin waɗannan marasa lafiya suna da abubuwan haɗari don haɓakar bugun zuciya na kullum. Wannan gaskiyar yakamata ayi la'akari dashi yayin rubuta magunguna hade tare da thiazolidinediones da shirye-shiryen insulin ga marasa lafiya. Tare da nadin irin wannan maganin haɗin gwiwa, ya zama dole don gudanar da gwaje-gwaje na likita na marasa lafiya don gano alamun da alamun cututtukan zuciya na rashin ƙarfi, hauhawar nauyi da kasancewar edema. Idan alamun cututtukan zuciya sun lalace a cikin marasa lafiya, tilas a dakatar da jiyya tare da thiazolidinediones.

Tasiri kan iya tuka motoci da injinan

Thearfin marasa lafiya su mai da hankali kuma ana iya rage ƙarfin tashin hankali yayin lalacewa, wanda zai iya zama haɗari a cikin yanayi inda waɗannan damar ke da mahimmanci musamman (alal misali, lokacin tuki motoci ko aiki tare da injuna da injuna).

Ya kamata a shawarci marassa lafiya su dauki matakan hana ci gaban hauhawar jini yayin tuki. Wannan yana da mahimmanci musamman ga marasa lafiya waɗanda ba su da alamu ko kuma rage alamun bayyanar cututtuka a cikin haɓakar ƙwanƙwasawa ko fama da cututtukan cututtukan cututtukan zuciya. A cikin waɗannan halayen, yakamata a yi la'akari da dacewar tuki da yin irin wannan aikin.

Hulɗa da ƙwayoyi

Akwai kwayoyi da yawa waɗanda ke shafar buƙatar insulin. Hypoglycemic sakamako na insulin inganta baka hypoglycemic kwayoyi, Mao hanawa, ACE hanawa, carbonic anhydrase hanawa ba zabe beta-blockers, bromocriptine, sulfonamides, anabolic steroids, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, kwayoyi lithium salicylates .

Sakamakon maganganu na insulin hypoglycemic na insulin yana raunana ta hanyar maganin hana haihuwa, glucocorticosteroids, hormones thyroid, thiazide diuretics, heparin, maganin tricyclic antidepressants, sympathomimetics, somatropin, danazole, clonidine, jinkirin tashar alli mai amfani, diazoxide, morphine.

Beta-blockers na iya rufe alamun bayyanar cututtukan jini.

Octreotide / lanreotide na iya haɓaka da rage buƙatar jiki ga insulin.

Barasa na iya haɓaka ko rage tasirin insulin.