MAGANIN ZINA

Metformin-Zentiva magani ne wanda aka shirya don maganin nau'in ciwon sukari na 2 (DM 2). Mai samarwa - Sanofi India Ltd. / Zentiva. Ya kasance cikin aji na biguanides. Baya ga babban dalilin, yana rage cholesterol da karin fam. Babban sinadaran aiki shine metformin hydrochloride.

Kayan aiki yana taimakawa rage yawan glucose ta hanta, yana jinkirta shan shi a cikin narkewa, kuma yana hana hadawar kitse. A cikin aiwatar da ci a cikin tsokoki, hankali ga insulin yana ƙaruwa. Metformin yana da tasiri mai kyau akan metabolism na lipid. Yana rage cholesterol, LDL, triglycerides. An rage yawan yawan sukari a cikin jini ta hanyar hana samuwar glucose. Yayin karatun, an samo daidaituwa ko raguwar matsakaici a cikin nauyin jikin mutum.

Alamu don amfani

An wajabta maganin a cikin waɗannan halaye:

• lura da masu ciwon sukari na 2
• lura da ciwon sukari irin 2 da insulin ko wasu magunguna masu rage sukari,
• rage rikice rikice daga tsarin zuciya da jijiyoyin jini a cikin mutane masu ciwon sukari na 2,
• hadadden far a lura da kiba.

Umarnin don amfani

An wajabta magungunan ga manya da yara daga shekara 10 bisa ga tsarin da ke gaba:

1. Monotherapy ko haɗuwa tare da wasu magunguna masu cin abinci

Suna farawa tare da ƙananan allurai - 500 mg sau 2-3 a rana. Bayan makonni 1-2, idan ya cancanta, daidaita sashi. Matsakaicin kashi shine 2000-3000 MG a allurai uku.

Ana cinye maganin sau 500-850 sau 2-3 a rana. Gyara allurar insulin.

1. Mutanen da ke da ƙananan ƙarancin ƙarancin renal sun fara shan 500 MG sau ɗaya a rana. Matsakaicin sashi shine 1000 mg 2 sau.

Contraindications

An sanya ƙwayar maganin a cikin waɗannan lambobin:

• rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi,
• matsakaici / mai rauni na kasawa,
• bugun zuciya
• barasa giya
• wani bugun zuciya,
• gazawar hanta
• ciki / lactation.

Side effects

Metformin yana da haƙurin haƙuri da haƙuri, amma a wasu halaye ana lura da mummunan halayen masu zuwa:

• rage sha na B12 (tare da tsawaita amfani da shi),
• rikicewar gastrointestinal
• ku ɗanɗani cin zarafi
• fata halayen
• lactic acidosis.

Yin hulɗa tare da wasu kwayoyi

Magungunan ba su dace da ethanol ba. Insulin, abubuwan da ke haifar da salicylic acid, MAO inhibitors, sulfonylureas, nootropics suna haɓaka aikin metformin. Na hana haifuwa na baka, hormones, diuretics, niacin, phenothiazines suna rage tasirin maganin.

Sharuɗɗan da yanayin ajiya na miyagun ƙwayoyi

Metformin Zentiva baya buƙatar yanayi na ajiyewa na musamman. An adana shi a zazzabi na 25 digiri a cikin kunshin na farko. Rayuwar shelf shine shekaru 3.

Kasuwancin kantin magani yana da magunguna da yawa dangane da metformin.

Shahararrun sunayen suna:

• Bagomet, Argentina,
• Glycomet, India,
• Glucophage, Faransa,
• Insufor, Turkiyya,
• Metformin Sandoz, Slovenia / Poland,
• Siofor, Jamus.

Nau'i na saki, abun da ke ciki

Allunan, farin da aka rufe fim, suna da yawa, biconvex, suna da haɗari don rarrabu a ɓangarorin biyu.

PRING sodium carboxymethyl sitaci - 40 mg, povidone 40 - 80 mg, colloidal silicon dioxide - 14 MG, sitaci masara - 20 mg, magnesium stearate - 6 mg.

Abun da keɓaɓɓen suturar fim: sephyphilm 752 fari (hypromellose - 35-45%, microcrystalline cellulose - 27-37%, macrogol stearate - 6-10%, titanium dioxide - 18-22%) - 20 mg, macrogol 6000 - 0.23 mg.

10 inji mai kwakwalwa - blister (1) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (3) - fakitoci na kwali.
10 inji mai kwakwalwa - blisters (6) - fakitoci na kwali.
10 inji mai kwakwalwa - blister (9) - fakitoci na kwali.

Aikin magunguna

Hypoglycemic magani don amfani da baka. Metformin shine biguanide tare da sakamako na hypoglycemic, wanda ke ƙayyade raguwa a cikin basal (azumi) da postprandial (2 sa'o'i bayan fara cin abinci) yawan ƙwayar glucose. Ba kamar magungunan sulfonylurea ba, metformin baya motsa ƙwayar insulin ta hanyar ƙwayoyin beta na pancreatic kuma baya haifar da haɗarin hypoglycemia.

Theara hankalin mai karɓar mahaifa zuwa insulin da kuma amfani da glucose ta sel. Yana rage haɓakar glucose ta hanta ta hanyar hana gluconeogenesis da glycogenolysis. Yana jinkirta ɗaukar ciki na glucose.

Metformin yana haɓaka aikin haɗin glycogen na ciki ta hanyar aiki akan glycogen synthase. Capacityara ƙarfin jigilar kayayyaki na kowane nau'ikan jigilar jini na membrane.

Metformin yana da tasiri mai amfani akan metabolism na lipid: yana rage yawan kuzari, LDL da triglycerides.

Yayin shan metformin, nauyin jikin mai haƙuri ko dai ya kasance tsayayye ko yana raguwa da matsakaici.

A cikin marasa lafiya masu shekaru 10-16 waɗanda aka bi da su tare da metformin na shekara 1, alamomin sarrafa glycemic sun kasance daidai da waɗanda ke cikin yawan balagaggu.

Pharmacokinetics

Bayan gudanar da baki, ana amfani da metformin a cikin narkewar abinci. Tare da max cimma 2,5 awa bayan shigowa. Bioavailability na allurai na 500 da 850 MG a cikin mutane masu lafiya shine 50-60%. Rashin haɗarin metformin lokacin da aka cika shi ya kasance cikakke kuma bai cika ba. Ana tsammanin cewa magungunan magungunan ƙwayoyin metformin ba shine layi ba. Lokacin da ake amfani da metformin a cikin allurai masu bada shawara kuma gwargwadon shawarar da aka bada shawara, ana samun C s a cikin plasma a cikin awanni 24-48 kuma yawanci basuda 1 /g / ml. C max metformin bai wuce 5 μg / ml ba, har ma lokacin amfani da miyagun ƙwayoyi a matsakaicin allurai.

Cin abinci yana rage digiri kuma yana rage jinkirin shan metformin. Bayan shigowa da kwamfutar hannu na 850 MG, raguwa a cikin C max na 40%, raguwa a cikin AUC na 25% da karuwa na 35 a cikin lokaci don isa zuwa C max.

An rarraba Metformin cikin hanzari a cikin kyallen takarda, kusan ba a ɗaura shi ga furotin plasma ba. Metformin yana shiga cikin sel jini. C max a cikin jini ya yi kasa da C max a cikin jini, kuma ana samun shi ta lokaci guda. Kwayoyin halittar jan rai, a dukkan alamu, sune keɓewar sakandare. Matsakaicin V d yana cikin kewayon lita 63-276.

Kodan an cire shi ta hanyar kodan, yana metabolized sosai kadan, ba a gano metabolites ba.

Bayan shan magungunan a cikin hanji, kashi 20-30% na abubuwan da ba a kwashe su ba sun kebe. Bayyanar danyen metformin ya zarce 400 ml / min, wanda ke nuna kawar da metformin ta hanyar narkewa mai aiki da tasirin tubular. Bayan gudanarwar baka, T 1/2 kusan awa 6.5.

Idan akwai rauni na aiki na koda, tarawa daga cikin magungunan mai yiwuwa ne, wanda ke haifar da haɓakar haɗarin metformin a cikin jini na jini.

Groupsungiyoyin haƙuri na musamman

Marasa lafiya tare da nakasa aiki na renal. Samun bayanan da aka samo a cikin marasa lafiya da ƙarancin isasshen na renal yan ƙalilan ne kuma basa bada izinin dogaro da sakamakon tasirin metformin a cikin wannan ƙaramar ƙungiyar, kamar yadda za'a iya yi a cikin mutane tare da aikin na al'ada.

Marasa lafiya na yara. Bayan amfani da metformin guda ɗaya a cikin kashi na 500 a cikin yara, an gano bayanin kantin magani wanda ya yi kama da wanda aka lura da shi a cikin manya masu lafiya. Bayan yin amfani da metformin akai-akai a kashi na 500 MG 2 sau / rana don kwanaki 7 a cikin yara, C max da AUC 0-t an rage su
kamar 33% da 40%, bi da bi, idan aka kwatanta da ƙimar waɗannan sigogi a cikin tsofaffi marasa lafiya da ciwon sukari waɗanda suka karɓi metformin a cikin sashi na 500 MG 2 sau a rana don kwanaki 14. Tunda an zaɓi kashi na miyagun ƙwayoyi daban-daban dangane da matakin ƙwayar cuta, waɗannan bayanan suna da ƙimar asibiti.

Sashi da gudanarwa

Ana ɗaukar magani a baka. Allunan ya kamata a ɗauka duka lokacin ko kuma nan da nan bayan abinci tare da karamin adadin ruwa.

Ya kamata a dauki Metformin Zentiva na miyagun ƙwayoyi kowace rana, ba tare da tsangwama ba. Idan an daina kulawa, mai haƙuri ya kamata ya sanar da likita.

Monotherapy da haɗin maganin haɗin gwiwa tare da sauran wakilai na bakin haɓaka

Maganin farko, a matsayin mai mulkin, shine 500 MG ko 850 mg sau 2-3 / rana bayan ko lokacin abinci. Furtherarin cigaba a hankali zai yiwu gwargwadon yawan glucose a cikin jini.

Bayan kwanaki 10-15 na amfani, dole ne a daidaita adadin ta yin la’akari da sakamakon aunawa da tattarawar glucose a cikin jini. Dosearfafawa mai saurin motsa jiki na iya taimakawa inganta haƙuri haƙuri.

Yawan kiyayewa yawanci shine 1500-2000 mg / rana. Don rage tasirin sakamako daga cututtukan gastrointestinal, ya kamata a raba kashi na yau da kullum zuwa kashi 2-3. Matsakaicin adadin shine 3000 MG / rana, ya kasu kashi uku.

Marasa lafiya da ke shan metformin a allurai na 2000-3000 mg / day za a iya canzawa daga shan allunan metformin a cikin adadin 500 MG zuwa shan Allformin Allunan a kashi na 1000 mg. Matsakaicin shawarar da aka bada shawara shine
3000 MG / rana, ya kasu kashi uku.

Dangane da batun canza canji daga shan wani wakili na hypoglycemic: dole ne ku daina shan wani magani kuma ku fara shan Metformin Zentiva a cikin adadin da aka nuna a sama.

Haɗin insulin

Don cimma ingantacciyar iko na glucose na jini, ana iya amfani da metformin da insulin azaman maganin haɗuwa. Matsayi na farko na Metformin Zentiva, a matsayin mai mulkin, shine 500 MG ko 850 mg sau 2-3 / rana, yayin da aka zaɓi kashi na insulin a kan tushen yawan haɗuwar glucose jini.

Marasa lafiya tare da nakasa aiki na renal

Za'a iya amfani da Metformin a cikin marasa lafiya tare da raunin matsakaici na matsakaici (CC 45-59 ml / min, GFR 45-59 ml / min / 1.73 m 2 na farfajiyar jiki) kawai a cikin rashin wasu yanayi waɗanda zasu iya ƙara haɗarin lactic acidosis, da a ƙarƙashin halaye masu zuwa na daidaitawar kashi: kashi na farko na Metformin Zentiva shine 500 MG ko 850 mg 1 lokaci / rana.

Matsakaicin adadin shine 1000 mg / rana, an kasu kashi biyu. Ana buƙatar saka idanu sosai akan aikin renal (kowane watanni 3-6).

Idan QC 2 na saman jikin, yakamata a daina Metformin Zentiva nan da nan.

Tsofaffi marasa lafiya

Sakamakon yiwuwar aiki na nakasa mai rauni, ana buƙatar zaɓi kashi na Metformin Zentiva na miyagun ƙwayoyi a cikin tsofaffi marasa lafiya a ƙarƙashin kulawar yau da kullun na alamun alamun aikin koda (ƙayyade taro na creatinine a cikin ƙwayar jini a kalla sau 2-4 a shekara).

Yara da matasa

A cikin yara masu shekaru 10 da haihuwa kuma mazan, ana iya amfani da maganin Metformin Zentiva duka biyu azaman monotherapy kuma a hade tare da insulin. Maganin farko, a matsayin mai mulkin, shine 500 MG ko 850 MG 1 lokaci / rana bayan ko lokacin abinci. Bayan kwanaki 10-15, dole ne a daidaita adadin gwargwadon abubuwan da ke nuna alamun taro a cikin jini. Matsakaicin adadin yau da kullun shine 2000 MG, ya kasu kashi 2-3.

Yawan damuwa

Bayyanar cututtuka: lokacin amfani dashi a kashi na 85 g (sau 42.5 mafi yawan maganin yau da kullun), ba'a lura da ci gaban hypoglycemia ba. Tare da ƙarin yawan ƙwayar cuta metformin, acid na lactate acid na iya haɓaka. Lactic acidosis gaggawa ne kuma yana buƙatar magani na cikin marasa lafiya. Dalilin ci gaban lactic acidosis kuma na iya zama tarin ƙwayar cutar saboda rauni na aikin keɓaɓɓu.

Alamomin farko na lactic acidosis sune tashin zuciya, amai, gudawa, zazzage jiki, zafin ciki, jin zafi, sannan kuma, saurin numfashi, farin ciki, rashin hankali da kuma ci gaba na rayuwa na iya faruwa.

A kan asalin abin da ya wuce haddi na metformin, cututtukan farji na iya faruwa.

Jiyya: idan akwai alamun lactic acidosis, magani tare da metformin ya kamata a dakatar da shi nan da nan, ya kamata a kwantar da mai haƙuri a cikin gaggawa, yawan lactic acid a cikin jini yana da ƙaddara kuma tabbatar da ganewar asali. Mafi inganci hanya don cire lactic acid da metformin daga jiki shine hemodialysis. Hakanan ana gudanar da aikin tiyata.

Yin hulɗa tare da sauran l / s

Iodine-dauke da kayan aikin rediyo

Gudanar da inshora na iodine-dauke da kayan aikin rediyo na iya haifar da ci gaban lalacewa na aiki, ta haka ne ya haɓaka tarin metformin da haɗarin lactic acidosis. A cikin marasa lafiya tare da GFR> 60 ml / min / 1.73 m2 na yankin farfajiyar jiki, ya kamata a dakatar da metformin kafin ko lokacin gwajin X-ray kuma ba a sake sabuntawa ba a cikin sa'o'i 48 bayan an gama, an tabbatar da aikin koda na al'ada. A cikin marasa lafiya da ke fama da rauni na matsakaiciyar matsakaici (GFR 45-60 ml / min / 1.73 m 2), ya kamata a dakatar da amfani da metformin awanni 48 kafin gudanar da maganin iodine-dauke da matsakaici kuma ya sake komawa ba a cikin sa'o'i 48 ba bayan kammala karatun kuma kawai bayan sake nazarin aiki na koda a cikin in babu alamun ta deterioration.

A cikin mummunan maye giya, haɗarin haɓakar lactic acidosis yana ƙaruwa, musamman dangane da matsananciyar yunwar ko rashin abinci mai gina jiki, bin abinci mai ƙarancin kalori ko tare da gazawar hanta. Yayin shan magungunan, ya kamata a guje wa barasa da kwayoyi masu ɗauke da ethanol.

Haɗuwa yana buƙatar taka tsantsan

Kada a bada shawarar yin amfani da gudaz din danazol a lokaci guda don guje wa tasirin karshen rayuwar. Idan jiyya tare da danazol ya zama dole kuma bayan dakatar da karshen, ana buƙatar daidaita sashi na metformin a ƙarƙashin kulawar tattarawar glucose na jini.

Chlorpromazine lokacin da aka ci shi a cikin allurai masu yawa (100 MG / rana) yana ƙara yawan haɗuwar glucose a cikin jini, yana rage ƙaddamar da insulin. A cikin maganin rigakafin ƙwayoyin cuta da kuma bayan dakatar da gudanarwarsu, ana buƙatar daidaita sashi na metformin a ƙarƙashin kulawar maida hankali na glucose jini.

GCS na tsari da aiki na gida yana rage haƙuri, yana ƙara haɗarin glucose a cikin jini, wani lokacin yana haifar da ketosis. A cikin maganin corticosteroids kuma bayan dakatar da shan nasu, ana buƙatar daidaita sashi na metformin a ƙarƙashin kulawar maida hankali na glucose a cikin jini.

Diuretics (musamman madaukai)

Yin amfani da "dip" diuretics lokaci guda na iya haifar da haɓakar lactic acidosis saboda gazawar aiki na iya aiki. Bai kamata a tsara Metformin ga marasa lafiya ba idan CC ta kasance ƙasa da 60 ml / min.

Beta 2 -adrenomimetics a cikin hanyar injections

Beta 2 -adrenergic agonists yana kara yawan glucose a cikin jini saboda yawan motsawar β 2 -adrenoreceptors. A wannan yanayin, yana da kyau a sa ido a kai a kai yayin tattara yawan glucose a cikin jini. Idan ya cancanta, ana bada shawarar yin insulin.

Tare da yin amfani da magungunan da ke sama guda ɗaya, za a iya daidaita sashin metformin yayin jiyya ko bayan ƙarewa.

Magungunan rigakafin ƙwayoyi, banda masu hanawar ACE, na iya canza yawan glucose a cikin jini. Idan ya cancanta, ya kamata a daidaita sashi na metformin.

Abubuwan da suka samo asali na sulfonylureas, insulin da acarbose

Tare da yin amfani da lokaci guda tare da metformin, haɓakar ƙwaƙwalwar ƙwayar cuta yana yiwuwa.

Tare da yin amfani da lokaci guda tare da metformin, haɓakar ƙwaƙwalwar ƙwayar cuta yana yiwuwa.

Yana ƙara sha da haɓaka C max na metformin.

Cationic kwayoyi

Amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprim da vancomycin, an cire su ta hanyar tubules na koda, gasa tare da metformin don tsarin jigilar tubular kuma yana iya haifar da haɓaka C max har zuwa 60%.

Rikicin hypoglycemic na metformin zai iya ragewa ta hanyar phenothiazines, glucagon, estrogens, ciki har da maganin hana haihuwa, phenytoin, mai juyayi, nicotinic acid, isoniazid, mai jinkirin tashar alli.

Levothyroxine na iya rage tasirin hypoglycemic na metformin. Ana ba da shawarar kulawa da tattarawar glucose na jini, musamman a lokacin qaddamarwa ko ƙaddamar da aikin maganin cututtukan thyroid, kuma idan ya cancanta, ya kamata a daidaita sashi na metformin.

Tare da yin amfani da metformin lokaci guda tare da NSAIDs, masu hana MAO, oxygentetracycline, abubuwan da ake amfani da su na fibroic acid, cyclophosphamide, probenecid, chloramphenicol, antimicrobials na sulfonamide, yana yiwuwa a haɓaka tasirin hypoglycemic na metformin.

A cikin masu sa kai na lafiya a cikin karatuttukan akan awo guda na metformin da propranolol, kazalika da metformin da ibuprofen, babu wani canji a cikin sigogin magunguna.

Metformin na iya rage sakamakon warkewar fenprocoumone na anticoagulant. Lokacin amfani dashi, ana bada shawarar kulawa da hankali sosai game da MHO.

Yayin ciki da lactation

Cutar cutar siga da ba a sarrafa ta ba yayin haihuwa tana da alaƙa da haɗarin haɗari na lalatattun cututtukan cikinku da mace-mace na haihuwa. Limitedarancin adadin bayanai sun nuna cewa shan metformin a cikin mata masu ciki baya ƙara haɗarin ci gaba da cutarwar cikin tayi. Karatun dabbobi bai nuna sakamako masu cutarwa ga masu juna biyu ba, haɓakar tayi ko tayi, hanyar aiki da ci gaban haihuwa.

Lokacin da ake shirin yin ciki, da kuma lokacin da ake ciki na ciki akan asalin shan metformin, yakamata a dakatar da maganin kuma ya kamata a tsara maganin insulin.

Wajibi ne a kula da matakin glucose na jini a matakin kusa da na al'ada don rage hadarin rashin aiki a tayin.

Metformin yakan shiga cikin madarar nono. Ba a lura da sakamako masu illa a cikin jarirai / jarirai yayin shan metformin. Koyaya, saboda iyakance bayanai, ba'a bada shawarar amfani da miyagun ƙwayoyi lokacin shayarwa ba. Dole ne a yanke shawarar dakatar da shayarwa ta la'akari da amfanin shayarwa da kuma haɗarin haɗarin sakamako masu illa ga jariri.

Side effects

Lokacin amfani da Metformin, waɗannan sakamako masu biyo baya na iya faruwa, waɗanda aka kasu kashi-kashi azuzuwan tsarin-tsari daidai da rabe-raben MedDRA. Dayyade yawan tasirin sakamako kamar yadda aka tsara a cikin WHO: sau da yawa (≥10%), sau da yawa (≥1% kuma Daga jini da tsarin lymphatic: mita ba a sani ba - anaemia hemolytic anemia.

Daga gefen metabolism da abinci mai gina jiki: da wuya - lactate acidosis, rage yawan bitamin B 12 a cikin marasa lafiya tare da megaloblastic anemia, ba a san mitar ba - tsinkayen neuropathy a cikin marasa lafiya tare da raunin bitamin B 12 rashi.

Daga tsarin juyayi: sau da yawa - murdiya dandano, ba a san tazarar ba - encephalopathy.

Daga narkewar abinci: sau da yawa - tashin zuciya, amai, zawo, ciwon ciki, asarar ci. Wadannan tasirin da ba'a so ba galibi suna faruwa yayin ƙaddamar da jiyya kuma a mafi yawan lokuta suna warware kansu. Don hana faruwar su, ana bada shawara don shan metformin na yau da kullun don allurai 2 zuwa 3 yayin cin abinci. Slowara sauƙaƙawa a cikin adadin ƙwayoyi na iya taimakawa inganta haƙuri daga ƙwayar gastrointestinal.

A ɓangaren fata da kyallen takarda na subcutaneous: da wuya - erythema, itching fata, urticaria, ba a san mita ba - photoensitivity.

A ɓangaren hanta da ƙwayar biliary: da wuya - ƙarancin aiki - haɓakar ƙwayoyin hepatic ko hepatitis, ɓacewa bayan cire magunguna.

Tasiri kan sakamakon dakin gwaje-gwaje da nazarin kayan aiki: ba a san mitar ba - raguwa a cikin taro na TSH a cikin plasma a cikin marasa lafiya tare da hypothyroidism, hypomagnesemia a kan asalin cutar gudawa.

Yara da matasa

Bayanan da aka buga, bayanai game da amfani da rajista bayan haka, da kuma sakamakon gwaji na asibiti a cikin iyakantaccen yawan yara a cikin 10-16 shekara kungiyar da aka bi da metformin na shekara 1, sun nuna cewa abubuwan da suka faru a cikin yara sunyi kama da yanayi da kuma tsananin tsananin ƙarfi ga waɗanda ke cikin manya marasa lafiya.

Umarni na musamman

Lactic acidosis ba kasafai ba ne, amma mai muni (babban mace-mace a cikin rashin magani na gaggawa), rikitarwa na rayuwa wanda zai iya faruwa sakamakon tarin metformin. Akwai rahotannin lokuta na lactic acidosis yayin jiyya tare da metformin a cikin marasa lafiya da ciwon sukari mellitus kuma tare da gazawar na koda ko ƙarancin rauni na aikin renal. Ya kamata a ba da kulawa ta musamman ga yanayin da narkewar daskararre na iya faruwa, alal misali, a yanayin rashin nutsuwa (tare da zawo ko amai) ko kuma a farkon farfaɗarin ƙwayar cutar farji ko tausa mai jiji (musamman “loopback”), da kuma a farkon maganin NSAID. Idan ana cikin yanayin waɗannan m, za a daina dakatar da jiyya tare da Metformin Zentiva na ɗan lokaci.

Sauran abubuwan haɗari masu haɗari yakamata ayi la'akari dasu, irin su deellensus deellensus mai narkewa, ketosis, tsawan azumi, yawan shan barasa, rashin hanta da duk wani yanayin da ya shafi hypoxia mai ƙarfi (alal misali, gazawar zuciya tare da hemodynamics mara tsayayye, gazawar numfashi, matsanancin ƙwayar myocardial infarction) )

Ya kamata a yi la’akari da haɗarin haɓakar lactic acidosis lokacin da alamun rashin daidaituwa suka bayyana, kamar ƙwayar tsoka, raunin dyspeptik, ciwon ciki, da kuma matsanancin asthenia. Ya kamata a umurce masu haƙuri da su sanar da likitan su kai tsaye game da abin da ya faru na waɗannan alamun, musamman idan mai haƙuri a baya ya yarda da maganin metformin da kyau. A wannan yanayin, ya kamata a dakatar da maganin tare da Metformin Zentiva, aƙalla na ɗan lokaci, har sai an fayyace lamarin. Tambayar resumption na farji dole ne a yanke shawara daban-daban, yin la'akari da fa'idar / hadarin rabo, da kuma yin la'akari da yanayin matsayin renal a cikin wannan haƙuri.

Bayyanar cututtuka: lactate acidosis yana halin rashin ƙarfi na acidotic na numfashi, zafi na ciki, hauhawar jini, biyo bayan coma. Manuniyar dakin gwaje-gwaje sun haɗa da: raguwa a cikin pH na jini (ƙasa da 7.25), taro na lactic acid a cikin plasma sama da 5 mmol / l, da haɓaka ragin anionic da rashi na lactate / pyruvate. Idan ana zargin metabolic acidosis, ya zama dole a daina shan metformin kuma a asibiti nan da nan mai haƙuri.

Yakamata likitocin su sanar da marasa lafiya game da hadarin lactic acidosis da alamunta.

Yakamata a daina shan maganin Metformin Zentiva 48 awanni kafin aikin tiyata da aka shirya a karkashin maganin sa barci, kashin baya ko maganin warkewa. Za'a iya fara amfani da warkaswa ba a cikin sa'o'i 48 bayan tiyata ko bayan maido da abincin abinci kuma kawai tare da aikin al'ada.

Domin metformin ya cire ta hanyar kodan, ya kamata a kula da mai nuna alamar QC kafin a fara maganin sannan a kai a kai:

- a kalla sau ɗaya a shekara a cikin marasa lafiya da keɓaɓɓen aikin koda,

- aƙalla sau 2-4 a shekara a cikin marasa lafiya tare da ƙimar CC a ƙananan ƙimar al'ada kuma a cikin tsofaffi marasa lafiya.

Tare da KK 2 saman jikin) amfani da miyagun ƙwayoyi Metformin Zentiva yana contraindicated.

Ragewa a cikin aikin koda a cikin tsofaffi marasa lafiya shine asymptomatic.

Ya kamata a yi taka tsantsan da hankali idan akwai yiwuwar aikin keɓaɓɓe na aiki idan aka sami rashin ruwa ko kuma tare da amfani da magungunan antihypertensive, cututtukan diuretics (musamman ma "madauki") ko NSAIDs. A cikin waɗannan halayen, an kuma bada shawara don bincika matsayin aikin koda kafin farawa tare da Metformin Zentiva.

Marasa lafiya tare da raunin zuciya suna da haɗarin haɓakar haɓakar hypoxia da gazawar koda. A cikin marasa lafiya da tsayayyen zuciya na rashin ƙarfi, za a iya amfani da magani na Metformin Zentiva a ƙarƙashin kulawar yau da kullun game da aikin zuciya da aikin koda.

Yin amfani da miyagun ƙwayoyi Metformin Zentiva yana cikin contraindicated a cikin marasa lafiya da m ko na kullum zuciya rashin cin nasara tare da m hemodynamics.

Metformin bai shafi aikin haihuwa ba ko na mace yayin da ake amfani da su ta hanyar allurai har zuwa 600 mg / kg / day, wanda shine kusan sau 3 sama da matsakaicin shawarar da aka bayar na yau da kullun a cikin mutane gwargwadon sakamakon kwatankwacin yanayin jiki.

Yara da matasa

Yakamata a tabbatar da gano cututtukan cututtukan type 2 na mellitus kafin fara jiyya tare da Metformin Zentiva.

A cikin gwaje-gwajen asibiti da aka sarrafa har abada shekara guda, ba a samo sakamakon metformin akan girma da balaga na yara ba. Koyaya, saboda rashin bayanai na dogon lokaci, ana bada shawara don kulawa da hankali sakamakon sakamako na metformin akan waɗannan sigogi a cikin yara suna ɗaukar Metformin Zentiva, musamman a cikin yara masu shekaru 10-12.

Sauran kiyayewa

- Marasa lafiya yakamata su bi abinci tare da cin abinci na yau da kullun a cikin kullun. Ya kamata marasa lafiya masu kiba su ci gaba da bin abincin mai ƙarancin kalori (amma ba kasa da 1000 kcal a kowace rana ba).

- Ya kamata a gudanar da gwaje-gwaje na dakin gwaje-gwaje na yau da kullun don magance ciwon sukari.

-Metformin baya haifar da hypoglycemia yayin monotherapy, duk da haka, ana ba da shawara yayin amfani dashi a hade tare da insulin ko wasu wakilai na hypoglycemic (alal misali, sulfonylureas, repaglinide).

- Dogon lokaci tare da metformin yana haɗuwa tare da raguwa a cikin taro na bitamin B 12 a cikin jini, wanda zai iya haifar da neuropathy na yanki. Ana bada shawarar saka idanu akai-akai game da ƙwayar plasma Vitamin B 12.

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa

Yin amfani da miyagun ƙwayoyi Metformin Zentiva azaman monotherapy ba ya shafar ikon fitar da motoci da ƙirar.

Lokacin da ake haɗuwa da Metformin Zentiva tare da sauran wakilai na hypoglycemic (ciki har da sulfonylureas, insulin, meglitinides), ya zama dole don faɗakar da marasa lafiya game da yiwuwar haɓaka yanayin hypoglycemic wanda ikon tuƙin motoci da kuma shiga cikin wasu ayyukan haɗari masu haɗari da ke buƙatar karɓar kulawa ya karu. da kuma m psychomotor halayen.

Metformin don asarar nauyi: umarnin don amfani, sake dubawa kuma nawa ne farashinsa?

Lokacin da lura da shirye-shirye na musamman waɗanda ke taimakawa rage nauyin wuce kima ba ya ba da sakamako bayyane, mutane da yawa sun fara amfani da kwayoyi waɗanda ke taimakawa rasa nauyi.

Ofaya daga cikin waɗannan magungunan shine Metformin, wanda ba kawai yana yaƙi karin fam ba, amma yana inganta haɓakar metabolism da inganta aikin gabobin ciki.

Koyaya, mutane da yawa suna sha'awar yadda ake ɗaukar Metformin don asarar nauyi don samun sakamako na bayyane da kuma kula da sakamako.

Menene metformin?

Metformin - wani magani, wanda kuma ake kira Glucofage, yana samuwa a cikin nau'ikan allunan kuma ana amfani dashi don rage sukarin jini. Ana amfani dashi sau da yawa don maganin cuta irin su ciwon sukari.

Magungunan suna da kyawawan abubuwan warkewa akan jikin mutum:

• Yana kawar da mummunan cholesterol kuma yana hana faruwar cutar atherosclerosis
• Yana hana aukuwar cututtukan kamar bugun jini sakamakon ci gaban ciwon sukari
• Ana amfani dashi don hana ci gaban ciwon sukari
• Cike da ci

Magungunan yana da sakamako masu illa kuma yana buƙatar gwaje-gwaje na musamman da kuma shawarar likita don tsara daidai gwargwado na miyagun ƙwayoyi.

Nawa zaka dauka?

Nawa kuke buƙatar ɗaukar wannan kayan don samun sakamako?

Don kula da cutar, ana sanya cutar guda ɗaya a cikin kowane mai haƙuri.

Mafi sau da yawa, daidaitaccen ma'aunin magani shine allunan 2 a kowace rana da safe da maraice. Ana amfani da miyagun ƙwayoyi tare da abinci.

Ya kamata a wanke kwamfutar hannu tare da ruwa mai yawa. Dangane da matsayin cutar, karuwa a cikin adadin ƙwayoyi kamar yadda likita ya umarta yana yiwuwa. Ba'a amfani da irin wannan magani ga shekaru yan ƙasa da shekara 20.

Zan iya rasa nauyi yayin shan Metformin?

Yin amfani da miyagun ƙwayoyi yana rage yawan sukari da rage haɓakar nama na adipose. Tabbas zaka iya rasa nauyi, amma zai iya jujjuya hanya mai nisa idan baka bin duk ka'idodi.

Don rage nauyi, ƙwayar tana da tasiri mai kyau ga jikin:

• Yana rage shaye-shayen carbohydrates kuma yana cire su ta dabi'a
• Oxidizes m acid da kuma hana su sha
• Yana kawar da wuce kima ta hanyar canza sel mai da kuzari zuwa jiki
• Yana haɓaka ɓangaren glucose mai narkewa ta hanyar ƙwayar tsoka
• Yana kawar da jin daɗin yunwar kullun.

Ya kamata ku sani cewa miyagun ƙwayoyi kadai ba zai iya kawar da ƙarin fam ba. Don yin wannan, dole ne ka fara lura da ingantaccen abinci mai gina jiki, da rage yawan abinci mai cutarwa. Hakanan yana da matukar muhimmanci a yi ayyukan motsa jiki na yau da kullun waɗanda zasu taimaka ci gaba da ƙarfafa sakamakon.

Ta yaya Metformin ke taimakawa rage nauyi?

• Yin amfani da Metformin yana rage yawan sukari kuma yana haɓaka metabolism, Sakamakon haka, adon mai ya watse cikin ƙananan barbashi, wanda aka juyar da shi zuwa makamashi, sauran an cire barbashin kitse daga jiki.
• Kari akan haka, abubuwan da ke jikin mutum wadanda ke amfani da su suna kunshe ne a cikin wani nau'in harsashi, wanda ke hana narkewar su, Sakamakon haka, ana fitar da carbohydrates daga jiki.
• Magungunan yana taimakawa kawar da mummunan cholesterol, wanda ke shiga jikin mutum tare da abinci mai takarce, kuma yana inganta jigilar sinadarai zuwa gabobin ciki, ta yadda suke inganta aikin su.
• Abincin da ya dace yana taimaka wa hana cutarwa daga shiga jiki. da kuma tarin ƙwayoyin mai, da kuma amfani da miyagun ƙwayoyi yana kawar da ƙarin fam.

Yadda za a sha Metformin don asarar nauyi?

Sau da yawa, yin amfani da miyagun ƙwayoyi yana faruwa ba tare da takardar izinin likita ba, don haka da farko ya kamata ku yi amfani da mafi ƙarancin ƙwayoyi.

A karo na farko kwanaki 10, ana bada shawarar yin amfani da allunan sama da guda biyu a rana, da safe da maraice. Ana ɗaukar kayan aiki bayan cin abinci, kuna buƙatar sha kwamfutar hannu tare da ruwa mai yawa.

Kawar da abinci kamar:

• Dadi.
• M.
• Soyayyen
• Itace.
• Barasa
• Nama da mai kifi
• Shaye-shayen Carbonated.
• Nama na ban sha.
• Kayan tsiran alade.
• Abincin gwangwani.

Bayan makonni da yawa na daidaitaccen ƙwayar magani, yana yiwuwa a ƙara kashi zuwa allunan uku a kowace rana. Hanyar amfani da miyagun ƙwayoyi bai wuce wata ɗaya ba, bayan wannan yana da buƙatar ɗaukar hutu na akalla watanni uku. Idan kun dauki Metformin na dogon lokaci, jaraba da raguwa sakamakon zai iya faruwa.

Zentiva metformin

Ana amfani da Metformin zentiva a cikin aikin likita a matsayin ɗayan magunguna don maganin ciwon sukari na 2. A yau, masana'antar masana'antu suna samar da adadi mai yawa na magunguna masu rage sukari da yawa, kuma metformin zentiva na ɗaya daga cikinsu.

Ofaya daga cikin manyan fa'idodin maganin shine,, sabanin kwayoyi waɗanda aka samo daga sulfonylureas, ba ya haifar da hypoglycemia. An bayyana wannan kadara ta hanyar gaskiyar cewa Metformin ba wani abu bane mai ƙarfafa ƙwayar insulin ta hanyar ƙwayoyin beta na pancreatic.

Umarnin don amfani

Allunan ana daukar su a baki. Ba da shawarar tauna ko yanke kwamfutar hannu ba. An lasafta ilimin aikin warkewa ne akan yawan maganin yau da kullun, tsawon wata 1.

Sashi don manya:

• An bada shawara don fara ɗaukar shi tare da sashi na 500 MG, tare da iyakar adadin yau da kullun na 1.5 g,
• sannu a hankali, bayan kwanaki 10, ana ƙaruwa sashi sau 850 mg sau 2-3 a rana ko har zuwa 1000 MG, tare da matsakaicin adadin yau da kullum na 3 g.

A wasu halaye, ana ba da izinin sauyawa daga 500 MG zuwa 1000 MG nan da nan. Ana yin lissafin sashi da kwatancin likita ne, gwargwadon yanayin mai haƙuri.

Innovation a cikin ciwon sukari - kawai sha kowace rana.

A lokacin jiyya tare da Metformin Zentiva, marasa lafiya masu kiba suna fuskantar raguwa a cikin nauyin jikin mutum ko ingantawarsa!

Metformin Richter

Ya kamata a ɗaukar allunan Metformin-Richter duka a lokacin ko kuma nan da nan bayan abinci, a wanke da ruwa kaɗan (gilashin ruwa). Don rage tasirin sakamako daga cututtukan gastrointestinal, ya kamata a raba kashi na yau da kullum zuwa kashi 2-3.

Saboda yawan haɗarin lactic acidosis, yakamata a rage kashi a cikin rikice-rikice na rayuwa mai rauni.

Abun ciki, siffofin saki

Magungunan suna cikin allunan tare da abun ciki tare da taro na metformin: 500, 850 ko 1000 mg.

Abubuwan da aka haɗa: sitaci carboxymethyl sitaci, povidone-40, aerosil, sitaci masara, E-572.

Abubuwan Da Aka Hada Fim: Sepifilm-752 (Farin) Macrogol-6000.

500 MG - zagaye, convex a bangarorin biyu, an rufe shi da farin kariya mai kariya.

850 MG da 1000 MG elongated, convex, a cikin farin murfin. A kan ɗayan saman kwayoyi 500 na kwayar cuta akwai tsararren rakodi wanda ke sauƙaƙa watsewa, kuma akan shirin 1000 MG ana amfani dashi a garesu.

An cushe a faranti firiji na guda 10. A cikin fakitin lokacin farin ciki kwali - 3/6/9 faranti tare da bayanin jagora.

Hanyoyin warkarwa

Magungunan an yi niyya don gudanar da maganin baka. Ana ba da sakamako na rage sukari ta babban fili - metformin. An hada sinadarin a cikin rukuni na biguanides - mahadi tare da kaddarorin hypoglycemic wanda zai iya daidaita abubuwan glycemic a cikin jiki. Ya bambanta da sauran abubuwan da ake amfani da su na sulfonylurea a cikin cewa wannan ba shi da tasiri a kan sel na tsibirin na Langerhans waɗanda suke haɗa sinadarin insogenous endogenous, sabili da haka baya bayar da tasu gudummawa ga abin da ya faru na rashin ƙarfi na jini.

Bayan shiga cikin jiki, yana inganta haɓakar mai karɓa ga insulin kuma yana kunna aiki na glucose. Bugu da kari, yana hana samuwar abubuwa a cikin hanta ta hanyar dakatar da hanyoyin glycogenolysis, gluconeogenesis kuma yana toshe yawan sha a cikin narkewa.

Metformin yana haɓaka hanyar glucose, yana da amfani mai tasiri akan ƙimar cutarwa da ƙwaƙwalwa mai amfani. Kusan babu wani tasiri akan tsarin karin fam.

Abubuwan sun shiga cikin narkewar narkewa, mafi girman hankali a cikin jini an kafa shi bayan sa'o'i 2-2.5. Yawan kuzarin rage abinci na iya raguwa saboda yawan abinci, kamar yadda hanzarin sha ya ragu. Metformin kusan baya amsawa tare da kariyar plasma, amma yana da ikon wucewa cikin sel jini.

Abun kusan shine bai samar da mahadi na rayuwa ba, kodan ya cire shi a kusan iri guda.

Hulɗa da miyagun ƙwayoyi

Matsakaicin farashin: 500 MG: (30 inji mai kwakwalwa.) - 133 rub., (Pcs 60.) - 139 rub. 850 MG: (30 inji.) - 113 rub., (60 inji.) - 178 rub. 1000 mg: (30 inji.) -153 rub., (60 inji.) - 210 rub.

Gudanar da cutar ta glycemia ta amfani da Metformin Zentiva ya kamata yayi la'akari da halayen haɗuwa tare da wasu kwayoyi. In ba haka ba, gudanar da magunguna lokaci guda na magunguna na kaddarorin daban-daban na iya haifar da halayen da ba a iya faɗi ba da kuma ci gaba mai illa.

Allunan suna contraindicated a sha tare da aidin-dauke da bambancin jamiái. Maƙeran sun ba da shawarar katse amfani da metformin kwana biyu kafin gwajin X-ray. An yarda da ci gaba da liyafar bayan ƙarshen hanyoyin, kuma bayan kwana biyu. Idan mai haƙuri ya yi watsi da contraindications, sakamakon hulɗa da magungunan zai zama gazawar aiki na koda, wanda zai haifar da tarawar metformin a cikin jiki kuma yana haifar da yanayin haɗari ga rayuwa - lactic acidosis.

Haɗin da ba a so

Barasa Shan magungunan kwayar cuta dangane da asalin mummunan guba mai guba yana taimakawa wajen haifar da lactic acidosis. Halin barazanar yana bayyana kanta musamman mawuyaci idan mai haƙuri yana fama da matsananciyar yunwa ko abinci (abinci, azumi) ko kuma yana da cuta ta hanta / koda. Domin kada ku tsokani mummunar lalacewa a cikin lafiya, yayin ɗaukar Metformin, kuna buƙatar ware abubuwan sha tare da barasa, kwayoyi tare da ethanol.

Haɗin haɗarin metformin tare da wasu kwayoyi waɗanda ke buƙatar sarrafa alama

• Danazole: ba a so a hada shi da metformin saboda tasirin cutar hyperglycemic. Idan ba zai yiwu a soke Danazol ba, ya kamata a sa ido a kai a kai kuma a daidaita shi gwargwadon alamun sukari.
• Chlorpromazine yana da ikon ƙara yawan ƙwayar cuta a cikin allurai masu yawa, yana hana sakin insulin.
• GCS rage haƙuri haƙuri, ƙara glycemia, a wasu yanayi na iya tsokani ketosis. Yayin gudanar da aikin GCS kuma bayan an soke su, kuna buƙatar canza tsarin sashi na metformin.
• Diuretics Gudanar da haɗin gwiwa na iya tayar da lactic acidosis saboda raguwa a aikin renal.
• Ag2-adrenergic agonists ta hanyar yin aiki akan masu karɓar raɗaɗin ƙara yawan abubuwan glucose na jini. Yana da mahimmanci a bincika yawan metformin ko maye gurbin shi da insulin.
• Magunguna tare da sulfonylurea, insulins da salicylates lokacin hulɗa tare da kwayoyin kwayoyi na Zentiva suna inganta tasirin hypoglycemic.
• Nifedipine yana haɓaka ƙwayar metformin kuma yana ƙaruwa da yawa a cikin jiki.
• Magunguna na ƙungiyar cationic, saboda gaskiyar cewa sun banbuɗe ta tubules na koda, sun shiga cikin gasa tare da metformin sabili da haka sun sami damar inganta abubuwan da ke ciki.
• Ayyukan Metformin Zentiva ya raunana a ƙarƙashin rinjayar phenositins, estrogens (ciki har da wani ɓangare na hana hana haifuwa), jinƙai mai juyayi, nicotinic acid, BKK, wakilin anti-TB Isoniazid.
• Ngarfafa aikin na Allunan tare da metformin za'a iya lura dashi lokacin da aka haɗa su tare da NSAIDs, MAOI, maganin Oxytetracycline, fibrates, cyclophosphamide, sulfonamides.
• Magunguna na iya rage tasirin Fenprokumon.

Side effects

Ikon ƙwayar cutar glycemia tare da taimakon ƙwayar magungunan Metformin Zentiva na iya kasancewa tare da tasirin da ba a ke so ta hanyar rikice-rikice iri-iri:

• Jini da tsotse: hemolytic anemia.
• Tsarin metabolism da abinci mai gina jiki: lactic acidosis, shan ƙwayar cyanocobalamin a cikin marasa lafiya tare da cutar rashin lafiyar B12 folio-rashi pathology. Hakanan, abin da ya faru na nakasasshen ƙwayar cuta a cikin marasa lafiya tare da rashi na vit ba a cire shi. B12.
• NS: dysgeusia, encephalopathy.
• Gastrointestinal fili: tashin zuciya, tashin hankali na amai, gudawa, zafin ciki, rage muradin ci. Abubuwan da ba a so ba galibi suna faruwa a farkon hanyar kulawa sannan kuma a hankali a ɓace yayin da allunan ke ci gaba da ɗauka. Don hana bayyanar su, ana bada shawarar sashi na yau da kullun don kasha kashi 2-3 kuma sha a lokacin ko bayan abinci. Wannan dabarar za ta tabbatar da shiga jikin kwayar cutar sannu a hankali tare da ba da gudummawa ga kyakkyawan yanayin jikin.
• Fata da s / c yadudduka na dermis: itching, urticaria, erythema, a wasu marasa lafiya - karuwa a cikin yiwuwar fata zuwa hasken rana da UV.
• Hanta: wani lokacin karuwa a cikin ayyukan enzymes wanda ke ɓoye bayan dakatar da hanya, hepatitis.
• Bayanin gwajin dakin gwaje-gwaje: raguwa a cikin abubuwan TT na hormone thyroid a cikin marasa lafiya tare da hypothyroidism, hypomagnesemia saboda zawo.

Hanyar Analogs

Idan ya cancanta, zaku iya amfani da magungunan da ke da alaƙa da Metformin, waɗannan sun haɗa da:

• Tsarin Novo.
• Siofor.
• Gliformin.
• Glucophage.
• Glyminfor.
• Kayan tsari.
• Glycon.
• Sofamet.
• Metospanin.

Ko da wane irin maganin analog, ya zama dole a yi nazarin umarnin daki-daki kuma ka san kanka da illolin sakamako.

Don rage nauyin magunguna ɗaya ba zai isa ba. Don samun sakamako na bayyane, ya zama dole don fahimtar matsalar gaba ɗaya. Yin amfani da Metformin yana ba ku damar fara aiwatar da rarraba adon mai, kodayake, idan akwai rashin bin tsarin abinci da aikin jiki, wannan magani ba zai yi tasiri ba.

Nazarin mutane game da metformin:

Metformin zentiva don asarar nauyi, umarnin

Idan waɗannan ƙwayoyin sun sami tsayayya, wannan shine, insulin hankali, to baza su iya samun glucose daga jini ba. Magungunan hypoglycemic na bakin, banda insulin. Da wuya fata ta halarta, gami da erythema, pruritus, urticaria.

Tare da yin amfani da lokaci guda tare da abubuwan da aka samo na sulfonylurea, acarbose, insulin salicylates, MAO inhibitors, oxygentetracycline inhibitors na ACE, tare da clofibratomycyclophosphamide, ana iya inganta tasirin hypoglycemic na metformin.

Ya zama mummunan yanayin da ke haifar da kiba, juriya insulin da hyperinsulinism.

Koyaya, babu bayanai game da tasirin metformin da na balaga tare da raunin metformin da yawa, sabili da haka, ana bada shawarar saka idanu akan waɗannan sigogi a cikin yaran da aka kula dasu tare da metformin, musamman lokacin balaga.

Metformin: umarnin don amfani don asarar nauyi

Menene zai iya maye gurbin Siofor? Tasirin rage ƙwayar sukari na ƙwayar cuta a bayyane kuma ana lura da shi a cikin duk marasa lafiya. Allunan mai rufe fim.

Bayan shan Allformin Allunan, zaku iya sha barasa cikin matsakaici kusan nan da nan, ba lallai ba ne a jira. Kuna iya ɗaukar darussan bitamin B12 sau ɗaya a shekara don hana rashi yayin ci gaba da magani tare da metformin.

Wannan yanayin ya haɓaka tare da Metformin, wanda aka ƙaddara shi da farko don kula da matakan sukari na al'ada a cikin ciwon sukari. Tabbas, tare da banda lokuta yayin da nauyin wuce haddi ya kama da ciwon sukari. Don rage rikicewar cututtukan sukari a cikin manya marasa lafiya da ke da nau'in ciwon sukari na 2 na mellitus mai nauyin 2 azaman magani na farko-tare da maganin rashin abinci.

Metformin: sake dubawa game da rasa nauyi

Siofor don asarar nauyi Siofor da wasu allunan metformin ana iya ɗauka don asarar nauyi ba kawai ga marasa lafiya da ke fama da ciwon sukari na 2 ba, har ma ga mutane masu lafiya. A saman wannan shafin, kun karanta abin da ya kamata tsarin magunguna ya zama don kauce wa zawo, zazzaɓi, ƙwanƙwasawa da sauran tasirin sakamako.

A sakamakon haka, a cikin ɗan gajeren lokaci na ƙara kusan kilo 20. Menene matsakaicin kashi a kowace rana? Kada ayi amfani dasu kafin aikin tiyata kuma cikin kwanaki 2 bayan an yi su. Zentiva Slovakia Lura cewa asalin maganin ba Siofor bane, amma Glucophage.

Allunan kwayoyin suna amfani da cutar da jiki

"Metformin" wani wakili ne wanda ake magana da shi wanda aka nuna don amfani dashi wajen lura da ciwon sukari na 2 na ciwon suga.

• Mene ne nau'i na saki na Metformin da abun da ke ciki?

Kwayar sinadarai mai aiki shine metformin hydrochloride, abun da ke ciki shine milligram 500. Wadanda suka kware sune: talc, povidone K90, a Bugu da kari, crospovidone, sitaci masara, dioxide titanium, magnesium stearate, macrogol 6000.

Magunguna na Metformin suna cikin allunan, suna zagaye da sifa da fari. An kawo shi cikin blisters na guda 10. Ana sayar da magunguna.

• Mene ne aikin Metformin na aiki?

Metformin yana cikin rukunin biguanides kuma yana da halaye na kayan aikin magani da ke nufin ragewa da kuma daidaita matakin glucose a cikin jini, ba tare da yin tasiri sosai kan aikin insulin ba.

Allunanin Metformin na iya haɓaka ayyukan tasirin glucose da kuma amfani ta hanyar kyallen mahaifa, musamman tsoka, wanda ke haifar da raguwa a cikin matakan carbohydrate. Yana da mahimmanci a tuna cewa ingantaccen amfani da sukari zai buƙaci isasshen aikin jiki.

Magungunan yana hana aiwatar da tsarin halitta na carbohydrates a cikin hanta, wanda ke da tasirin gaske yana tasiri abubuwan da ba kawai glucose ba, har ma da haɗarin triglycerides. Normalization na matakan lipid yana da tasirin gaske akan hanyar ciwon sukari, yana hana ci gaban rikitarwa.

Metformin yana taimakawa ragewa da kuma daidaita nauyin mai haƙuri. Gaskiya ne, wannan baya kawar da buƙatar bin wani abinci na musamman tare da rage abun ciki na carbohydrates da fats.

Magungunan yana da tasirin fibrinolytic, sanadin wanda shine ɓangaren jujjuyawar ƙwayar ƙwayar plasminogen mai kunnawa inhibitor. Inganta zagayawa da jijiyoyin jini yana aiki ne don hana ci gaban cututtukan jijiyoyin jiki wanda yawanci yana haɗuwa da ciwon sukari.

Metformin yana cikin tallacen hanji cikin hanji. A warkewa maida hankali ne na miyagun ƙwayoyi ke tsiro 2.5 hours bayan gudanarwa. Magungunan yana da matukar sauƙi ga tarawa kuma yana iya tarawa a cikin irin waɗannan kyallen takarda: glandon glandon, hanta, ƙari, kodan, tsokoki.

Ana aiwatar da haɓakar metformin hydrochloride tare da fitsari. Maƙƙarfan rabin rai yana yin daga 9 zuwa 12 hours. Tare da cutar koda, wannan mahimmancin alamar yana iya ƙaruwa.

• Me Metformin ke yi, menene fa'ida ga jikin ɗan adam daga gare ta?

Gudanar da ƙwayar sukari na rage sukari na Metformin (Allunan) yana ba da damar yin amfani da mellitus na ciwon sukari na nau'in na biyu (tare da rashin ingancin maganin abinci, aikin jiki, musamman a haɗe tare da babban kiba).

Metformin a cikin nau'in 2 mellitus na ciwon sukari ya kamata a ɗauka a ƙarƙashin kulawa na ƙwararru tare da sakamakon nazarin dakin haƙuri. Amfani mara izini na iya haifar da mummunan sakamako.

Amfani da Metformin don ciwon sukari na 2 ba a yarda da shi ba a yanayin da aka nuna a ƙasa:

• Rashin nauyi mai yawa a cikin hanta, • Rashin rauni, • Cutar ciki, • Zazzabi, • Ciwon mahalli mara nauyi, • Buƙatar jiyya na tiyata, • Losic acidosis, • Muguwar giya,

Bugu da ƙari, ba a amfani da kayan aiki don yanayin hypoxic.

• Menene kashi don metformin? Yaya ake ɗaukar Metformin don ciwon sukari?

Maganin ingantaccen kuma mai aminci yawanci yana daga miligram 500 zuwa 1 gram na metformin hydrochloride kowace rana. A nan gaba, dangane da matakin glucose, zaku iya daidaita adadin magungunan da aka sha. Matsakaicin adadin yau da kullun shine 3 grams.

Metformin miyagun ƙwayoyi, wanda muke ci gaba da magana akai game da wannan shafin www.rasteniya-lecarstvennie.ru, bai kamata a murƙushe ko chewed ba. Ana bada shawara don shan maganin sau 2 zuwa 3 a rana, bayan abinci, tare da rabin gilashin ruwa. Jiyya yakan zama tsawon rai.

• Shin Zai yiwu maganin hana daukar ciki na Metformin?

Bayyanar cututtuka sune: rage yawan zafin jiki, zawo, amai, tashin zuciya, tsananin ƙarfi, da kuma yawan numfashi. Jiyya kamar haka: asibiti na gaggawa, hemodialysis, farjin cututtukan mahaifa.

• Menene tasirin metformin?

Lokacin ɗaukar Metformin, bayanin - bayanin da aka sanya a cikin kunshin, ya gargadi marasa lafiya cewa magani tare da miyagun ƙwayoyi na iya kasancewa tare da alamu mara kyau. Misali, yana iya zama: ciwon ciki, zawo, rage cin abinci, dandano mai narkewa a cikin bakin, ƙwannafi, halayen rashin lafiyan mutum, tsananin farin ciki, ciwon kai, ƙari, rauni, da kuma canje-canje a gwajin jini.

Yanayin cututtukan zuciya yana tattare da rauni da kuma tsananin fushi. Wannan ya cancanci tunawa idan an tilasta wa mai haƙuri ya bi ingantaccen magani wanda ya shafi amfani da metformin da sauran magunguna masu rage sukari. Tare da monotherapy, irin wannan sakamakon kusan ba zai taɓa faruwa ba.

• Yaya za a maye gurbin metformin?

Metadiene, Siofor 500, Bagomet, Metformin Novartis, Metospanin, Metformin-Teva, Metformin-BMS, Langerine, Metformin-Canon, Sofamet, Nova Met, Gliformin, form Pliva, Glucofage dogon, Metformin hydrochloride, Metfogamma 850, Metfogamma 1000, , Metformin MV-Teva, NovoFormin. Siofor 1000, Glycon, Glucofage, Metformin Zentiva, Metformin Richter, Siafor, Glyformin Prolong, Glyminfor, Diaformin OD, Metformin, Metfogamma 500, kazalika da Formmetin.

Marasa lafiya ya kamata su tuna cewa shan magunguna masu rage sukari ba ya kawar da buƙatar biye da abincin da ake amfani da shi. Bugu da ƙari, aiki na jiki da buƙatar kulawa da glucose na yau da kullun suna da mahimmanci. Kar ku manta game da buƙatar barin kyawawan halaye.

Metformin don asarar nauyi: yadda za a sha shi, abin da za a ji tsoron + sake dubawa daga waɗanda suka rasa nauyi da likitoci

A kan ajanda, wani abu mai ban sha'awa wanda ya riga ya dauki mafi yawa a cikin maganin cutar ciwon sukari, wani lokacin za'a iya amfani dashi akan hanyar zuwa ga siririn jiki kuma ana yin nazarinsa sosai azaman maganin tsufa. Metformin don asarar nauyi: yadda zaka iya ɗaukar shi daidai, wa zai iya gwada shi, kuma wa zai fi kyau idan ba tare da shi ba, sake dubawa na likitoci da mutanen da suka rasa nauyi daga cikin taro da kuma a zahiri.

Menene metformin?

Wannan magani ne na rage sukari na jini wanda ke aiki ta hanyar hayewa. Ba kai tsaye ke motsa farji da ke motsa sinadarin insulin ba, amma yana shafar hanzari da karfin haɓakar carbohydrate a cikin wasu gabobin jikin mutum - a bayan fitsarin.

Maɓallin rubutu mai sauri:

Menene hanyoyin da metformin yake aiki a jiki

Jerin kayan aikin yau da kullun yana da ban sha'awa. A cikin abincin bushewar masana'anta, zaku iya karanta shi a cikin kowane umarnin hukuma (buƙatar "umarnin metformin don amfani").

A cikin kalmomi masu sauƙi, an bayyana babban amfanin maganin a cikin hoton da ke ƙasa.

Tsarin hanyoyin da aka lissafa na aiki daidai sun dace da maganin cututtukan da yawa:

1. Ciwon sukari mellitus
2. Rashin daidaituwa game da haƙuri na glucose ("ciwon suga"),
3. Kiba da ciwo na rayuwa,
4. Cleopolycystic ovary a cikin mata.

Hakanan ana amfani da Metformin a magungunan motsa jiki da kuma rigakafin tsufa.

Magungunan yana rage glycation na furotin - ɗayan manyan abubuwan da ke haifar da kumburi da ke haifar da ƙwayar cuta. Tuni akwai al'ummomin masu sha'awar amfani da maganin don tsawan matasa. Shahararren Elena Malysheva ya bayyana ra'ayoyin ra'ayoyin metformin sau da yawa. Wannan ba karya bane ko karin bayani bane, amma cikar maganganun kimiyyar zamani.

Hyperinsulinism - Matsalar yawan kiba

Insulin wani sinadari ne wanda ƙwayar ƙwayar jijiya ke samar da ita. Matsayinsa jagora ne na kwayoyin glucose a cikin sel: “Sannu! Mun san junanmu! Ina tare da abinci, za mu ci abincin rana! ”

Hyperinsulinism wani yanayi ne na cuta yayin da ƙwayar huhu ta samar da isasshen insulin don ɗaukar abinci, amma ana shan wahala sosai daga jini sakamakon raguwar hankalin masu karɓar nama.

"Ba mu san shi ba - ƙara maida hankali ne!" - buƙatun cutar ta ta biye. Nama shine yake cikawa: akwai ƙarin insulin a cikin jini.

Kuma wannan tarko ne don kara yawan ajiyar kitse a jiki!

Saboda yawan taro a kodayaushe yana inganta adon mai: carbohydrates mara amfani da sunadarai sunadarai sosai suna sarrafa mai sosai.