Amoxiclav - umarnin don amfani, sake dubawa, analogs da siffofin sashi (allunan 125 mg, 250 mg, 500 mg, 875 mg, 1000 mg, dakatarwa) na maganin don maganin cututtukan cututtukan cikin manya, yara da ciki

A cikin wannan labarin, zaku iya karanta umarnin don amfani da miyagun ƙwayoyi Ammarlalav. Yana ba da ra'ayi daga baƙi zuwa rukunin yanar gizon - masu amfani da wannan magani, kazalika da ra'ayoyin kwararrun likitocin game da amfani da Amoxiclav a cikin aikin su. Babban buƙatar shine a ƙara ra'ayoyin ku game da miyagun ƙwayoyi: maganin ya taimaka ko bai taimaka kawar da cutar ba, menene rikice-rikice da sakamako masu illa da aka lura, mai yiwuwa ba sanar da mai masana'anta ba a cikin bayanin. Analogs na Amoxiclav a gaban wadatattun analogues na tsarin ana amfani dasu. Yi amfani da shi don maganin cututtukan cututtuka daban-daban a cikin manya, yara, har ma yayin daukar ciki da lactation. Amfani da barasa da sakamako mai yuwuwa bayan shan Amoxiclav.

Ammarlalav - yana haɗuwa da amoxicillin - penisillin semisynthetic tare da ɗaukar hoto mai yawa na aikin kashe ƙwayoyin cuta da kuma acid na clavulanic - wani inhibitor beta-lactamase mai hanawa. Clavulanic acid shine ya samar da hadaddun barikin tare da wadannan enzymes kuma yana tabbatar da juriya da amoxicillin zuwa tasirin beta-lactamases wanda kwayoyin halitta suka haifar.

Clavulanic acid, mai kama da tsari don maganin rigakafin beta-lactam, yana da rauni mai hana ƙwayoyin cuta.

Amoxiclav yana da tsalle-tsalle iri iri na aikin hana ƙwayoyin cuta.

Yana da ƙarfi a kan nau'ikan kula da amoxicillin, gami da nau'ikan samar da beta-lactamases, incl. kwayoyin aerobic gram-tabbatacce, aerobic gram-kwayoyin cuta, anaerobic gram-tabbatacce kwayoyin, gram-korau anaerobes.

Pharmacokinetics

Babban ma'aunin magunguna na amoxicillin da clavulanic acid sun yi kama. Abubuwan haɗin duka suna haɗuwa sosai bayan shan miyagun ƙwayoyi a ciki, cin abinci baya shafar ƙimar sha. Dukansu abubuwan haɗin suna haɗuwa da ingantaccen girma na rarrabewa a cikin ruwan jiki da kyallen takarda (huhu, kunne na tsakiya, pleural da peritoneal ruwaye, mahaifa, ovaries, da sauransu). Har ila yau, Amoxicillin ya shiga cikin hanji mai narkewa, hanta, glandon prostate, ƙwanƙarin palatine, ƙwayar tsoka, ƙonewar mafitsara, ɓoyewar sinuses, ciwan, hanji. Amoxicillin da clavulanic acid ba su shiga cikin BBB ba tare da meninges wanda ba a bayyana shi ba. Amoxicillin da clavulanic acid sun haɗu da katangar ƙwarya kuma a cikin abubuwan da aka gano suna keɓance a cikin madara. Amfani da ƙwayar cuta mai narkewa da kuma clavulanic acid ana ɗaukar su ta hanyar ƙananan ɗauri don sunadaran plasma. Amoxicillin yana cikin metabolized, clavulanic acid a fili yana fuskantar matsanancin metabolism. Amoxicillin an cire shi da kodan kusan ba a canza shi ta hanyar tubular ɓoyewa da kuma ruɗar murfin ƙasa. Clavulanic acid an raba shi ta hanyar dunƙule ƙasa, wani ɓangare na metabolites.

Alamu

Cututtukan da ke haifar da cututtukan ƙwayoyin cuta mai lalacewa:

kamuwa da cuta na hanji na huhu da gabobin ENT (gami da sinusitis mai raɗaɗi da jijiyoyin wuya, matsanancin ƙwaƙwalwar ƙwayar otitis, ƙwayar jijiyoyin ƙwayar cuta, ƙwanƙwasa hanji, ƙwayar cuta),
cututtuka na ƙananan ƙwayar jijiyoyin jiki (ciki har da babban mashako tare da superinfection na kwayan cuta, mashako na kullum, ciwon huhu),
urinary fili cututtuka
cututtukan mahaifa
cututtukan fata da fata na laushi, gami da dabbobi da ciwan mutum,
kashi da kuma haɗin nama,
cututtukan biliary fili (cholecystitis, cholangitis),
odontogenic cututtuka.

Sakin Fom

Foda don shirin allura don gudanarwar cikin ciki (4) 500 MG, 1000 MG.

Foda don shirye-shiryen dakatarwa don sarrafawa na maganin 125 mg, 250 MG, 400 MG (nau'i mai dacewa ga yara).

Allunan da aka rufe fim din 250 MG, 500 MG, 875 MG.

Umarnin don amfani da sashi

Manya da yara kanana shekaru 12 (ko sama da kilo 40 na nauyin jiki): maganin da aka saba don kamuwa da cuta zuwa matsakaici shine kwamfutar hannu 1 + 250 + 125 mg a kowace awa 8 ko kuma kwamfutar hannu 1 500 + 125 mg a kowane sa'o'i 12, idan akwai wani mummunan kamuwa da cuta. da cututtukan cututtukan ƙwayar cuta - 1 kwamfutar hannu 500 + 125 MG kowane 8 hours ko 1 kwamfutar hannu. 875 + 125 MG kowace awa 12. Ba a ba allunan allunan ga yara 'yan shekara 12 (kasa da kilo 40 na nauyin jiki).

Matsakaicin adadin yau da kullun na clavulanic acid (a cikin nau'i na gishiri na potassium) shine 600 MG na manya da 10 mg / kg na nauyin jiki ga yara. Matsakaicin adadin amoxicillin shine 6 g na manya da 45 mg / kg na nauyin jikin yara.

Aikin magani shine kwanaki 5-14. Dogon likitan ne ya tantance tsawon lokacin da ake bi da shi. Jiyya kada ta wuce kwanaki 14 ba tare da binciken likita na biyu ba.

Sashi don kamuwa da cututtuka na odontogenic: 1 shafin. 250 +125 mg kowane 8 hours ko 1 kwamfutar hannu 500 + 125 MG kowane 12 na tsawon kwanaki 5.

Sashi don gazawar renal: ga marasa lafiya da gazawar matsakaiciyar matsakaici (Cl creatinine - 10-30 ml / min), kashi shine 1 tebur. 500 + 125 MG kowane sa'a 12, don marasa lafiya da gazawar rashin lafiyar koda (creatinine Cl ƙasa da 10 ml / min), kashi shine 1 tebur. 500 + 125 MG kowane 24 hours

Side sakamako

Abubuwan da ke haifar da sakamako a cikin mafi yawan lokuta masu laushi ne da kan lokaci.

asarar ci
tashin zuciya, amai,
zawo
ciwon ciki
pruritus, urticaria, erythematous na gaggawa,
angioedema,
anaphylactic shock,
rashin lafiyan vasculitis,
exfoliative dermatitis,
Stevens-Johnson ciwo
leukopenia wanda ke iya juyawa (ciki har da neutropenia),
thrombocytopenia
hawan jini,
eosinophilia
farin ciki, ciwon kai,
rashi (na iya faruwa a cikin marassa lafiya da ke fama da rauni game da aiki yayin shan kwayoyi)
jin damuwa
rashin bacci
cutuka nephritis,
babbar murya
ci gaban superinfection (gami da candidiasis).

Contraindications

rashin jituwa ga kowane ɓangare na magungunan,
hypersensitivity a cikin tarihi zuwa maganin penicillins, cephalosporins da sauran maganin rigakafin beta-lactam,
tarihin shaidar cutar cholestatic jaundice da / ko sauran ayyukan hanta mai lalacewa ta hanyar shan amoxicillin / clavulanic acid,
na ciwon maɗamfari mononucleosis da cutar kuturta.

Haihuwa da lactation

Ana iya ba da maganin Amoxiclav yayin daukar ciki idan akwai alamun bayyanannu.

Amoxicillin da acid na clavulanic a cikin adadi kaɗan an keɓance su cikin madara.

Umarni na musamman

Tare da hanyar kulawa, ya kamata a sa ido kan ayyukan jini, hanta da kodan.

A cikin marasa lafiya da ke fama da rauni na aiki na kyanda, ana buƙatar cikakkiyar gyaran allurar rigakafi ko karuwa a tsakanin tazara tsakanin dosing.

Don rage haɗarin mummunan sakamako daga cututtukan gastrointestinal, ya kamata a sha miyagun ƙwayoyi tare da abinci.

Gwaje-gwaje na dakin gwaje-gwaje: babban adadin amoxicillin yana ba da amsa ta gaskiya ga ƙin fitsari lokacin amfani da renon ɗin Benedict ko mafita. Ana bada shawarar halayen enzymatic tare da glucosidase.

An haramta amfani da Amoxiclav tare da amfani da giya a lokaci daya a cikin kowane nau'i, tunda haɗarin cutar hanta yayin ɗaukar su a lokaci guda yana ƙaruwa sosai.

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa

Babu bayanai game da mummunan tasirin Amoxiclav a cikin allurai da aka bada shawarar akan iya tuki mota ko aiki da injin.

Hulɗa da ƙwayoyi

Tare da amfani da magani na lokaci guda tare da Amoxiclav tare da antacids, glucosamine, laxatives, aminoglycosides, sha yana rage gudu, tare da ascorbic acid - yana ƙaruwa.

Diuretics, allopurinol, phenylbutazone, NSAIDs da wasu kwayoyi waɗanda ke toshe ɓarin tubular ƙara yawan haɗarin amoxicillin (clavulanic acid an ware shi musamman ta hanyar lalata ƙasa).

Tare da yin amfani da lokaci mai amfani da Amoxiclav yana kara yawan guba na methotrexate.

Tare da yin amfani da Amoxiclav tare da allopurinol lokaci guda, haɗarin exanthema yana ƙaruwa.

Ya kamata a guji gudanar da ayyukan haɗin kai tare da disulfiram.

A wasu halaye, shan miyagun ƙwayoyi na iya tsawan lokacin prothrombin, a wannan batun, yakamata a yi taka tsantsan yayin da ake rubuta magungunan anticoagulants da kuma miyagun ƙwayoyi na Amoxiclav.

Haɗin amoxicillin tare da rifampicin antagonistic ne (akwai rauni na juna game da tasirin ƙwarin ƙwayar cuta).

Kada a yi amfani da Amoxiclav a lokaci guda tare da kwayoyin rigakafin ƙwayoyin cuta (macrolides, tetracyclines), sulfonamides saboda raguwar yiwuwar tasirin Amoxiclav.

Probenecid yana rage haɓakar amoxicillin, yana ƙaruwa da ƙwaƙwalwar magani.

Magungunan rigakafi suna rage tasirin maganin hana haifuwa.

Analogues na kwayoyin rigakafin Amoxiclav

Tsarin analogues na mai aiki abu: