Umarnin don amfani da magani Simvagexal® da sake dubawa game da shi

Nau'in farko na IIa da nau'in IIb hypercholesterolemia (idan maganin rage cin abinci ba shi da kyau a cikin marasa lafiya tare da haɗarin haɓakar haɓakar atherosclerosis), haɗewar hypercholesterolemia da hauhawar jini, hyperlipoproteinemia, wanda abinci na musamman da aikin jiki ba zai iya daidaita shi ba.

Yin rigakafin yaduwar ƙwayar cuta ta mahaifa (don rage ci gaban cututtukan ƙwayar cuta daga zuciya), bugun jini da rikicewar jiki na jijiyoyin zuciya.

Yadda ake amfani: sashi da hanya na jiyya

A ciki, sau ɗaya, da yamma. Tare da mai laushi ko matsakaici hypercholesterolemia, kashi na farko shine 5 MG, tare da mummunan hypercholesterolemia a farkon kashi na 10 MG / rana, tare da isasshen maganin, ana iya ƙara kashi (ba a makonni 4 ba), matsakaicin adadin yau da kullun shine 80 MG.

Tare da cututtukan zuciya na zuciya, kashi na farko shine 20 MG (sau ɗaya, da maraice), idan ya cancanta, a hankali ana ƙara yawan kashi a kowane mako 40 zuwa 40 mg. Idan taro LDL ya zama ƙasa da 75 mg / dl (1.94 mmol / L), yawan ƙwayoyin cholesterol ba su da ƙasa da 140 mg / dl (3.6 mmol / L), yakamata a rage kashi.

A cikin marasa lafiya da gazawar na koda (CC kasa da 30 ml / min) ko karɓar cyclosporine, fibrates, nicotinamide, kashi na farko shine 5 MG, matsakaicin adadin yau da kullun shine 10 MG.

Aikin magunguna

Magungunan lipid-lowering da aka samu ta hanyar kayan zazzagewa Aspergillus terreus wani lactone ne mara aiki; ana yinsa ne a jikin mutum don samar da wani sinadari na hydroxy acid. Mai aiki na metabolites yana hana HMG-CoA reductase, enzyme wanda ke ɗaukar matakin farko na samuwar mevalonate daga HMG-CoA. Tunda canzawar HMG-CoA zuwa mevalonate shine farkon matakin fara aiki a cikin kwayar cholesterol, yin amfani da simvastatin baya haifar da tarin abubuwan guba a jikin mutum. HMG-CoA yana da sauƙin haɗuwa da acetyl-CoA, wanda ke shiga cikin ayyukan da yawa na jiki.

Yana rage taro na TG, LDL, VLDL da jimlar cholesterol a cikin plasma (a cikin yanayin heterozygous familial da kuma rashin familial na hypercholesterolemia, tare da haɗuwa da hyperlipidemia, lokacin da hauhawar cholesterol shine haɗarin haɗari). Concentara yawan taro na HDL kuma yana rage yawan rabo na LDL / HDL da jimlar cholesterol / HDL.

Farawar aiki shine makonni 2 bayan farawar, mafi girman tasirin warkewa shine bayan makonni 4-6. Sakamakon ya ci gaba da ci gaba da magani, tare da dakatar da jiyya, abubuwan da ke cikin cholesterol sun koma matakin farko (kafin jiyya).

Side effects

Daga tsarin narkewa: dyspepsia (tashin zuciya, amai, gastralgia, ciwon ciki, maƙarƙashiya ko zawo, flatulence), hepatitis, jaundice, ƙara yawan aiki na "hanta" transaminases da alkaline phosphatase, CPK, da wuya - m pancreatitis.

Daga tsarin juyayi da gabobin jijiya: asma, danshi, ciwon kai, rashin bacci, rashi, paresthesias, neuropathy na waje, hangen nesa, mara hangen nesa, illa mai illa.

Daga tsarin musculoskeletal: myopathy, myalgia, myasthenia gravis, da wuya rhabdomyolysis.

Allergic da immunopathological halayen: angioedema, lupus-like syndrome, polymyalgia rheumatism, vasculitis, thrombocytopenia, eosinophilia, ƙarar ESR, amosanin gabbai, arthralgia, urticaria, daukar hoto, zazzabi, zazzabin fata, fitar da fuska.

Abubuwan da ke tattare da cututtukan cututtukan fata: fatar fata, itching, alopecia.

Sauran: anemia, palpitations, gazawar na koda (saboda rhabdomyolysis), raguwar iko.

Umarni na musamman

Kafin fara magani, ya zama dole a gudanar da bincike kan aikin hanta (sanya ido kan ayyukan “hanta” transaminases duk mako 6 na farkon watanni 3, sannan kowane mako 8 na sauran shekarar farko, sannan kuma sau daya a kowane wata shida). Ga marasa lafiya da ke karɓar simvastatin a cikin adadin yau da kullun na 80 MG, ana kula da aikin hanta sau ɗaya a kowane watanni 3. A yanayin da aikin “hanta” transaminases ya ƙaru (ya wuce sau 3 mafi girma na yau da kullun), an soke jinya.

A cikin marasa lafiya tare da myalgia, myasthenia gravis da / ko tare da alamar karuwa a cikin aikin CPK, an dakatar da maganin miyagun ƙwayoyi.

Bai kamata a yi amfani da Simvastatin (kazalika da sauran hanawar HMG-CoA reductase inhibitors) tare da haɓakar haɗarin rhabdomyolysis da gazawar renal (saboda mummunan kamuwa da cuta, cututtukan jijiyoyin jini, babban tiyata, rauni, da rikice-rikice na rayuwa).

Canza magunguna masu rage rage kiba a lokacin daukar ciki ba ya da wani tasiri a sakamakon gwajin magani na dogon lokaci na maganin hypercholesterolemia.

Sakamakon gaskiyar cewa HMG-CoA reductase inhibitors na hana cholesterol kira, da kuma cholesterol da sauran samfuran saututtukan sun taka rawar gani a cikin ci gaban tayin, gami da haɗarin steroids da membranes cell, simvastatin na iya samun mummunar illa ga tayin idan aka wajabta mata masu ciki ( ya kamata mata masu haihuwa suyi taka tsantsan da hanyoyin hana haihuwa). Idan ciki ya faru a lokacin jiyya, ya kamata a dakatar da miyagun ƙwayoyi, kuma ya kamata a faɗakar da matar game da haɗarin yiwuwar tayi.

Ba a nuna Simvastatin ba a cikin lokuta inda akwai nau'in I, IV, da V hypertriglyceridemia.

Yana da tasiri duka a cikin hanyar monotherapy, kuma a hade tare da jerin abubuwan bile acid.

Kafin kuma lokacin gudanar da magani, mai haƙuri ya kamata ya kasance a kan rage yawan abincin da ake kira hypocholesterol.

Idan aka rasa kashi na yanzu, ya kamata a sha magani kamar yadda ya kamata. Idan lokaci yayi na gaba, kar ku ninka kashi biyu.

A cikin marasa lafiya da mummunan gazawar koda, ana gudanar da jiyya a ƙarƙashin ikon aikin aikin koda.

An shawarci marasa lafiya da su ba da rahoton nan da nan game da raunin da ba a bayyana ba, tashin hankali, ko rauni, musamman idan yana tare da zazzabi ko zazzabi.

Haɗa kai

Yana haɓaka sakamakon maganin rashin daidaituwa kuma yana haɓaka haɗarin zub da jini.

Theara yawan taro daga cikin digoxin a cikin jini.

Cytostatics, magungunan antifungal (ketoconazole, itraconazole), fibrates, babban allurai na nicotinic acid, immunosuppressants, erythromycin, clarithromycin, masu hana kariya suna kara hadarin rhabdomyolysis.

Colestyramine da colestipol suna rage bioavailability (yin amfani da simvastatin mai yiwuwa ne awanni 4 bayan shan waɗannan kwayoyi, tare da tasirin ƙari).

Tambayoyi, amsoshi, sake dubawa game da miyagun ƙwayoyi Simvageksal

Bayanin da aka bayar an yi shi ne don ƙwararrun likitoci da magunguna. Cikakken bayani game da magani yana kunshe ne a cikin umarnin da aka haɗe zuwa marufin da mai masana'anta. Babu wani bayani da aka sanya akan wannan ko wani shafin yanar gizon mu wanda zai iya canza matsayin roko na musamman ga kwararrun.

Halin Magunguna

Samun Simvageksal ana aiwatar da shi ta hanyar damuwa da Jamusanci Hexal AG. Babban dalilin wannan magani shine rage ƙananan ƙwayoyin jini, triglycerides da ƙarancin lipoproteins mai yawa.

Wannan magani yana cikin rukunin magunguna na gumakan. An samo shi daga sinadarin Aspergillus terreus, wanda samfuri ne na enzymatic. INN: Simvastatin. Nadin Simvagexal kamar likita yana faruwa lokacin da mai haƙuri ya gano:

• na farko da kuma haɗin hypercholesterolemia,
• basir.

Siffofin fasalin sakin jiki da farashin maganin

Ana samun wannan maganin a cikin nau'in kwamfutar hannu. Waɗannan allunan ellipsoidal ne a cikin kwasfa na launin toka-ruwan hoda ko inuwa mai launi (dangane da sashi), tare da ƙirar musamman da zane. Latterarshe ya ƙunshi haruffa uku na farko waɗanda ke da alaƙa da sunan miyagun ƙwayoyi (SIM) da lamba da ke nuna matakin taro na ƙwayar mai aiki.

Bayanai game da matsakaicin farashin Simvagexal don wannan magani a Rasha an ba su a cikin tebur.

Simvagexal nasa ne ga shirye-shiryen tsarin halitta kuma yana da abubuwan da ke cikin sa guda ɗaya - simvastatin. Harshen da ke rufe kwamfutar hannu ya ƙunshi abubuwa waɗanda ke da ayyuka na agaji. Ya ƙunshi sitaci, cellulose, butylhydroxyanisole E320, magnesium stearate, ascorbic acid da citric acid, 5 cps da 15 cps hypromellose, titanium dioxide, rawaya da jan ƙarfe oxide.

Bayanai kan magunguna da kuma magunguna

Simvagexal wakili ne mai rage rage karfin jini. Ingestion na simvastatin yana tare da hydrolysis, wanda ya haifar da samuwar wani sinadari na hydroxy acid.

Magungunan na iya rage ƙwayoyin triglycerides, masu ƙarancin ƙarfi da ƙarancin lipoproteins (LDL), da jimlar cholesterol (OX). Bugu da ƙari, yana ba da gudummawa ga karuwar lipoprotein mai girma (HDL) da raguwa a cikin rabo na OX / HDL zuwa LDL / HDL.

Kuna iya tsammanin sakamakon shan wannan magani bayan kwanaki goma zuwa kwanaki goma sha huɗu daga farkon jiyya tare da Simvagexal. Ana samun sakamako mafi ƙoshin warkewa bayan wata daya ko rabi da allunan akai-akai.

Jerin alamomi da contraindications

Umarnin don maganin yana nuna cewa an yi amfani dashi don amfani a cikin yanayi biyu:

1. Idan akwai buƙatar gyaran cholesterol da samfuran metabolism na lipid.
2. Idan akwai hadarin rikitarwa da ke tattare da tsarin na zuciya, da jijiyoyin zuciya, ciwon suga, amai da wasu cututtukan da ke da alaƙa da ƙwaƙwalwar ƙwayar cuta.

Wannan magani magani ne mai mahimmanci wanda aka wajabta wa marasa lafiya da ke fama da cututtukan hypercholesterolemia (asalin asali ko asali), da kuma cututtukan zuciya daban-daban. Wannan ya zama dole a lokuta yayin daidaita abinci ba ya ba da tasiri.

Bayan ɗaukar Simvagexal ta hanyar marasa lafiya waɗanda suka kamu da matsaloli a cikin aikin ƙwaƙwalwar zuciya, an lura da masu zuwa:

• raguwa a cikin mace-mace sakamakon kamuwa da cututtukan zuciya,
• rigakafin cututtukan zuciya, shanyewar jiki,
• raguwa a cikin yiwuwar kamuwa da cuta da jijiyoyin jini,
• hana bukatar yin aikin tiyata wanda aka yi don dawo da farfadowa na yanki,
• rage hadarin asibiti saboda angina pectoris.

Daga cikin contraindications zuwa far tare da Simvagexal, akwai:

Matsalar da ta danganta da gurɓataccen sel halittar jini (porphyria),

Mahimmanci! Wannan magani ba da shawarar don amfani da mata ba yayin daukar ciki, tunda akwai shaidar tasirinsa mara kyau a tayin, wanda ke haifar da ci gaba na rashin hankali a cikin yaro.

Har ila yau matan da ke shirin haihuwa, wadanda suke shirin yin juna biyu suma su guji magani da simvastine. Idan ciki ya faru yayin ɗaukar Simvagexal, ya kamata ka daina amfani da shi.

Babu bayanai game da yadda kayan aiki na wannan magani ke shayar da nono. Yayin lactation, ba da shawarar Simavhexal.

Wa'azin wannan magani ga yara da matasa masu shekaru goma sha takwas ana yin su tare da taka tsantsan saboda rashin bayanai kan aminci da tasirin Simvagexal dangi da wannan rukunin marasa lafiya.

Akwai halaye waɗanda ke wajabta magunguna tare da taka tsantsan cikin ƙananan matakan kuma tare da gwaje-gwaje na lokaci-lokaci na ƙididdigar jini. Wadannan sun hada da:

• mai rauni na koda
• rikicewar endocrine
• da alama ciwon sukari
• hauhawar jini
• shan giya
• marasa lafiya da ke da alaka da shekaru bayan shekaru 65,
• concomitant far tare da bitamin B3, fusidic acid, Amiodarone, Verapamil, Amlodipine, Dronedaron, Ranolazine.

Siffofin magani

Simvagexal, bisa ga umarnin don amfani da shi, ana ɗaukar sau ɗaya a rana. Wannan ya kamata a yi da yamma maraice. Ana wanke magani sosai da ruwa. Tsawon lokacin likita shine wanda likita ya umarta. Ba'a ba da shawarar ku canza kashi ɗaya da tsarin shan magani ba.

Idan aka rasa magungunan, to za a iya bugu da maganin a kowane lokaci na daban, wanda zai bar maganin ba canzawa. An saita babban sashi ne gwargwadon matakin ƙwayar cholesterol da aka lura a cikin makonni huɗu na mako.

Daidaitaccen sashi shine 40 milligram na simvagexal. Ana iya haɓaka shi zuwa milligram 80 a kowace rana idan akwai haɗarin cututtukan zuciya kuma matakan warkewa basu da tasiri sosai.

An tsara wa marasa lafiya da ke fama da cututtukan zuciya na zuciya kashi 20 na milligram. Bayan wata daya, idan ya cancanta, an kara sashi zuwa 40 milligram. Tare da raguwa a cikin jimlar cholesterol zuwa 3.8 mmol / lita ko lessasa, ana rage yawan allunan da aka dauka.

Cutar zuciya

Idan mai haƙuri ya sami ƙarin ƙarin jiyya tare da Cyclosporine, Nicotinamide ko fibrates, to, ana rage fifiko da matsakaita na yau da kullun zuwa milligram 5-10. Ana ɗaukar ɗayan matakan guda ɗaya idan an gano gazawar na koda.

Zai yiwu sakamako masu illa da wuce haddi

A cikin jerin illolin sakamako masu illa daga maganin cutar sankara, zaka iya ganin masu zuwa:

1. Daga hankula da tsarin juyayi: abin da ya faru na raɗaɗi a cikin ƙwayar tsoka, cututtukan asthenic, dizzness, hangen nesa mara nauyi, damuwa, rashin jin daɗi, damuwa a cikin kai, hargitsi na bacci, jijiyoyin mahaifa.
2. Daga gefen tsarin narkewa: maƙarƙashiya, tashin zuciya, dyspepsia, amai, ciwon ciki, ƙaruwar hanta, ƙwayar phosphokinase (CPK), haɓakar iskar gas, ciwon huhu, cututtukan hanji, hepatitis.

Ba a kafa takamaiman bayyanar cututtuka dangane da abin da ya shafi ƙwayar magani (matsakaicin izinin sashi shine 450 milligrams).

Jerin analogues

Daga cikin analogues na Simvagexal, wanda ke dauke da sinadaran aikin simvastine, za'a iya bambance masu zuwa:

Simvastol na Hongeriyanci.Akwai shi a cikin kwamfutar hannu fom a sashi na 10 da 20 milligrams. Kunshin ya ƙunshi Allunan 14 da 28. Wannan kayan aiki yana da cikakkiyar tasirin kamawa ga Simvagexal, jerin abubuwan alamomi da kuma contraindications. Kafin ɗaukar magungunan, an wajabta wa mai haƙuri maganin rage yawan hypocholesterol.

Ana shan miyagun ƙwayoyi sau ɗaya a rana da yamma. Yawan maganin yau da kullun da likitocin suka bada shawara sun bambanta daga milligram 10 zuwa 80, gwargwadon ganewar asali da kasancewar cututtukan haɗuwa. Ga mafi yawan masu haƙuri, mafi kyawun kashi wanda ke ba da tasirin warkewa da ake so shine milligram 20. Kudin maganin yana kama daga 169 zuwa 300 rubles.

Daga cikin sauran magungunan analog ana bada shawarar: Vazilip (Slovenia), Zokor (Netherlands), Simvalimit (Latvia), Simgal (Isra'ila), Zorstat (Croatia), Avenkor (Russia), Simvastatin (Russia), Sinkard (Indiya).

Magungunan Simvagexal: alamomi don amfani, analogues, bita

A cikin ciwon sukari na mellitus, yana da mahimmanci ba kawai don auna sukari jini ba, har ma don ɗaukar gwaje-gwaje a kai a kai domin ƙwayar cholesterol. Idan wannan alamar ta wuce, likitan ya ba da umarnin abinci na warkewa na musamman da magani.

Mafi shahararrun magunguna don hypercholesterolemia shine Simvagexal, yana nufin magungunan lipid tare da sinadaran simvastatin mai aiki.

Allunan sun dace da kula da marassa lafiya wadanda shekarunsu suka wuce 18. Zaka iya siyan su a kowane kantin magani yayin gabatar da takardar sayan magani. An ƙaddara maganin ne ta hanyar likita daban-daban, yana mai da hankali kan tarihin likita, kasancewar contraindications da ƙananan cututtuka.

Yaya maganin yake aiki?

Shirye-shiryen da aka samu na roba daga samfurin enzymatic Aspergillus terreus ya rage yawan abubuwan da ke cikin plasma na triglycerides, mai kananzir mai yawa da rashin ƙarfi, kuma yana ƙara yawan abubuwan da ke tattare da yawan ƙwayoyin lipoproteins.

Ana iya ganin sakamako na farko na farko bayan kwanaki 14 bayan farawar rashin lafiya. Ana samun tasirin warkewar hankali sannu a hankali, bayan wata daya da rabi.

Yana da mahimmanci a kammala ajiyar aikin magani don kula da matakan al'ada na dogon lokaci.

Likita ya ba da magani idan mai haƙuri yana da:

• Hypercholesterolemia,
• Sakamako,
• Hada hypercholesterolemia.

Ana amfani da magani idan abinci na musamman bai taimaka ba. Hakanan, ana ba da izinin yin amfani da allunan don dalilai na rigakafi idan akwai haɗarin infarction myocardial tare da ƙirar cholesterol fiye da 5.5 mmol / lita.

Baya ga simvastatin mai aiki, allunan kamannin launuka masu launin fari, rawaya ko ruwan hoda dauke da sinadarin ascorbic, sinadarin iron, lactose monohydrate, sitaci masara, magnesium stearate, hypromellose, titanium dioxide.

Umarnin don amfani da miyagun ƙwayoyi

Dangane da littafin da aka makala, kuna buƙatar ɗaukar Simvagexal da maraice sau ɗaya a rana, kuna shan ruwa mai yawa. Tsawan likitan ne yake tantance tsawon lokacin da likitan yake halarta, yana canza yanayin da kansa kuma ba a ba da izinin tsari ba.

Idan an rasa kashi na yanzu, ana ɗaukar magani a kowane lokaci, yayin da sashi ɗin ya kasance iri ɗaya. Bayan bincika mai haƙuri, nazarin tarihin likita da gwaje-gwaje, likita ya yanke shawarar yawan allunan da ake buƙata a matakin farko na magani.

An kafa babban kashin, yana mai da hankali kan matakin plasma na cholesterol, wanda aka samu a tsakanin tsakanin makonni huɗu.

1. A daidaitaccen sashi, mai haƙuri yana ɗaukar 40 MG kowace rana. Za'a iya ƙara wannan girman zuwa 80 MG kowace rana a gaban haɗarin zuciya yayin da jiyya ba ta da tasiri.
2. Marasa lafiya tare da cututtukan zuciya na zuciya suna ɗaukar nauyin 20 a kowace rana. Bayan wata daya, kashi idan ya cancanta ya karu zuwa 40 MG. Game da raguwar adadin cholesterol zuwa 3.6 mmol / lita kuma a ƙasa, an rage adadin allunan.
3. Idan an kara wa mutum magani tare da Cyclosporine, Nicotinamide ko fibrates, ana rage kashi na farko da mafi girman maganin yau da kullun zuwa 5-10 MG. Ana ɗaukar irin waɗannan ayyukan idan akwai gazawar na koda.

Wanda aka contraindicated da magani magani

Yana da mahimmanci a la'akari da cewa allunan suna da contraindications da yawa, saboda haka magungunan kai ba za a taɓa yi ba. Kafin ɗaukar Simvagexal, kuna buƙatar karanta umarnin don amfani.

Farashin miyagun ƙwayoyi tare da sake dubawa masu inganci shine 140-600 rubles, ya danganta da kunshin. A cikin kantin magani zaka iya samun fakitin 5, 10, 20, 30, 40 MG. Don yin daidaitaccen aikin likita, an bada shawarar siyan allunan Hexal Simvagexal 20mg cikin adadin 30 inji mai kwakwalwa.

Magungunan yana contraindicated idan mai haƙuri yana da:

• gazawar hanta
• rashin hankali ga abubuwan da ke cikin miyagun ƙwayoyi,
• hankali na mutum-mutumi,
• ciwon kai
• take hakkin samuwar sel jini (porphyria).

Ba za ku iya aiwatar da magani ba idan mutum yana shan Itraconazole, Ketoconazole, magunguna don maganin cututtukan HIV a layi daya. Haka kuma, allunan suna contraindicated a cikin mata masu juna biyu da kuma lactating mata.

Yakamata a yi taka tsantsan lokacin da mara lafiya ya sha giya, aka bi shi da immunosuppressants, yana da haɓaka ko rage sautin ƙwaƙwalwar tsoka, yana fama da cututtukan fata, matsanancin cuta, hauhawar jijiyoyin jini, matsanancin endocrine da cuta na rayuwa. Ana gudanar da aikin tiyata a tsakanin marasa lafiya da shekarunsu suka wuce 18.

A lokacin daukar ciki, ya fi kyau a ƙi ƙurar, tunda a cikin al'amuran likitanci na ci gaban asma a cikin yaro bayan an yi rikodin allunan yau da kullun.

Side effects

Lokacin da ake rubuta magani tare da kwayoyin hana daukar ciki, likita dole ne ya tabbatar cewa mara lafiyar baya shan wasu kwayoyi. Mai haƙuri, bi da bi, dole ne ya sanar da likita game da irin magungunan da ya riga ya sha. Wannan ya zama dole don guje wa hulɗa da ba a yarda da wasu kwayoyi.

Musamman, tare da yin amfani da fibrates, cytostatics, babban allurai na nicotinic acid, Erythromycin, masu hana kariya, wakilan antifungal, immunosuppressants, Clarithromycin, rhabdomyolysis na iya haɓaka.

Sakamakon karuwa da maganin hana daukar ciki na bakin jini, na iya zub da jini, saboda haka kuna bukatar kulawa sosai da yanayin jinin yayin aikin jiyya. Simvagexal yana ƙara yawan ƙwayar plasma na digoxin. Idan mai haƙuri ya yi amfani da cholestyramine da colestipol a baya, ana ba da damar amfani da allunan kawai bayan sa'o'i huɗu.

1. Abubuwan da ke haifar da sakamako suna bayyana ta hanyar jijiyoyin tsoka, cututtukan asthenic, rashi, hangen nesa, huhu, rashin ƙarfi, ciwon kai, rashin bacci, ƙwaƙwalwa na gefe.
2. Akwai maganganun cututtukan narkewa a ciki, maƙarƙashiya, tashin zuciya, dyspepsia, amai, jin zafi a cikin ciki, ƙwanƙwasa, ciwon huhu, zawo, hepatitis.
3. A cikin lokuta mafi sauƙi, ana lura da rashin lafiyar jiki a cikin nau'i na fata itching da kurji, polymyalgia rheumatica, thrombocytopenia, zazzabi, ƙaruwar erythrocyte sedimentation, urticaria, gajeriyar numfashi, eosinophilia, angioedema, hyperemia na fata, vasculitis, amosanin gabbai, lupusus, etisisususus, etisisususus, etisisusususus, etisisususus, etisusususmatusus
4. Mutum na iya fuskantar myalgia, myopathy, rauni na gaba ɗaya, rhabdomyolysis. Sakamakon haka, iko yana raguwa, bugun jini yana ƙaruwa, anemia ta haɓaka, da kuma gazawar hanta.

Game da yawan abin sama da ya kamata, a matsayinka na mai mulki, takamaiman bayyanar cututtuka ba su bayyana, amma yana da mahimmanci don cire abu mai wuce haddi a jiki. Don yin wannan, mai haƙuri yana amai, ba gawayi gawayi. Yayin aikin jiyya, ya zama dole don saka idanu kan matakan serum na phosphokinase, aikin koda da hepatic.

Idan kun dauki mutum-mutumi na wani lokaci mai tsawo, a cikin wani yanayi mai rauni ya kamu da cutar huhu, wanda ke tare da busasshen tari, haɓaka da yanayin janar, ƙara yawan gajiya, raunin nauyi, da sanyi.

Shawarwarin likitoci

Idan mutum yayin aiwatar da jiyya yana kara yawan aikin phosphokinase da jijiyoyin tsoka sun bayyana, lallai ne ya bar tsananin aiki.

Hakanan yakamata ya kawar da abubuwan da ke haifar da karuwar ƙwayar enzyme, wanda ya haɗa da kasancewar zazzaɓi, tsokoki, raunin da ya faru, cututtukan fata, cututtukan fata, guba na carbon dioxide, polymyositis, dermatomyositis, barasa da shan kwayoyi. Idan bayan wannan aikin enzyme ya ci gaba da ƙaruwa, ya kamata a bar allunan Simvagexal gaba ɗaya, maimakon haka, zaku iya amfani da analogues daga wasu masana'antun.

Kafin farawa likita, likita dole ne ya gudanar da gwajin jini don aikin KFK. Wannan hanya ya kamata a maimaita bayan watanni uku. Ana aiwatar da aikin samarda magungunan phosphokinases a cikin tsofaffi da kuma marassa lafiyar da suka kamu da cutar sukari mai daskararrakin jini, cututtukan jini, ana aiki da nakasa a cikin shekarar.

Ga kowane nau'in ciwon sukari, ya zama dole a gudanar da gwajin glucose na jini koyaushe, tunda maganin yana taimakawa wajen ƙara yawan sukari a cikin ƙwayar.

Wasu marasa lafiya suna haɓaka haɓakar cuta, wanda ke buƙatar magani na musamman.

Amma likitoci ba su bayar da shawarar dakatar da magani tare da mutum-mutumi ba, tunda haɓaka cholesterol na iya haifar da mummunar rikice-rikice a cikin masu ciwon sukari idan ba a kula da su yadda yakamata ba.

Allunan yakamata a ɗauka tare da taka tsantsan idan mai haƙuri yana shan giya. Idan akwai raguwa a cikin aikin thyroid, cutar koda, babban cutar ana magance shi da farko, bayan haka zaka iya fara rage yawan ƙwayar cholesterol a cikin jini.

Irin waɗannan magungunan sun hada da Zokor, Avestatin, Sinkard, Simgal, Vasilip, Aterostat, Zorstat, Ovenkor, Holvasim, Simplakor, Actalipid, Zovatin da sauransu.

Abinci don rage cholesterol

Baya ga shan magunguna, dole ne mai haƙuri ya bi tsarin abinci na hypocholesterol, wanda ya ƙunshi cin abinci mai ƙima cikin ƙima na dabbobi. Cikakken abinci mai gina jiki na iya inganta yanayin tasoshin jini da kuma kawar da alluran atherosclerotic.

Abubuwan da aka haramta sun hada da ƙoshin dabbobi da mai cike da ƙiba, man shanu na halitta, margarine, ƙoshin abinci mai mai, sausages, da sausages. Mai haƙuri ya ƙi ƙwanƙwaran kwai, soyayyen dankali, ganyayyaki, kayan lemo da kayan ƙamshi mai tsami.

Hakanan, an ware daga cikin biredi, madara duka, madara mai daure, cream, kirim mai tsami, cuku gida mai yawa ana buƙatar daga abincin.

An ba da shawarar cewa mai haƙuri ya tsarma jita-jita tare da soya, canola, zaitun, sesame da sauran man kayan lambu, waɗanda ke dauke da mayukan omega-uku.

Kuna buƙatar cin naman kifi, kullun, mackerel da sauran nau'ikan kifin mai, nama mai laushi, kaji, turkey. Irin waɗannan abincin sune kyakkyawan tushen furotin.

Tsarin abinci ya ƙunshi kowane irin hatsi da aka dafa akan ruwa, gurasar alkama, abinci mai yalwar abinci, manyan kayan lambu da 'ya'yan itatuwa.

Tare da ciwon sukari na kowane nau'in, ba za ku iya zaluntar Sweets, pies, biscuits ba.

Abincin warkewa tare da ƙwayar cholesterol yana da ƙa'idodi masu yawa waɗanda ya kamata a bi. Giya da giya, kofi, shayi mai ƙarfi gaba ɗaya suna haɓaka, ana amfani da abinci mai ƙoshin sitaci a cikin mafi ƙarancin adadi.

Abincin ya hada da kayan lambu, 'ya'yan itatuwa, kayan kiwo mai ƙarancin kitse. Abincin da aka soya ana maye gurbinsa da shi ta abinci da aka dafa. Abincin da aka dafa broths ana cinye shi ba tare da mai mai ba. Ana amfani da kaji da aka yi da shiri akan tebur ba tare da fata ba, ba a amfani da mai a lokacin dafa abinci. Ana cin ƙwai kaza ba tare da yolks ba.

Abincin abinci mai gina jiki zai sauƙaƙa yawan ƙwayoyin cuta, kare tasoshin jini da hanta. A cikin kwanaki bakwai na farko, mai haƙuri yana jin daɗin rayuwa, tunda tsarin narkewa bai bayyana ga damuwa ba. Irin wannan abincin ba shi da contraindications, kamar yadda yake daidaita, saboda haka yana da girma ga masu ciwon sukari.

Yadda za'a iya daidaita metabolism na lipid a cikin bidiyon a wannan labarin.

Nuna sukari ko zaɓi jinsi don shawarwari Bincike ba'a samo ba Bincike ba'a samo ba

SIMVAGEXAL

- hypercholesterolemia na farko (nau'in IIa da IIb bisa ga rarrabuwa na Fredrickson) tare da rashin tasirin maganin abinci tare da ƙarancin cholesterol da sauran matakan rashin magunguna (aiki na jiki da asarar nauyi) a cikin marasa lafiya tare da haɗarin haɗari na atherosclerosis, - haɗuwa da hypercholesterolemia da hypertriglyceridemia, na musamman Abincin abinci da motsa jiki, - IHD: hanawa daga infarction cututtukan ƙwaƙwalwar ƙwayar cuta (hanawa na ƙananan rauni) a cikin marasa lafiya tare da ƙara yawan sha fitar da cholesterol (> 5.5 mmol / l).

Pharmacokinetics

DamuwaSamun simvastatin yana da girma. Bayan gudanar da baki, Cmax a cikin plasma na jini ya isa bayan kimanin sa'o'i 1.3-2.4 kuma yana raguwa da kusan 90% bayan sa'o'i 12.RarrabaYin kwanciyar hankali ga furotin plasma ya kusan kashi 95%.Tsarin rayuwaYana yin tasirin "hanyar farko" ta hanta. An inganta shi ta hanyar samar da abubuwa masu aiki, beta-hydroxyacids, da sauran metabolites masu aiki da marasa aiki.KiwoT1 / 2 na metabolites mai aiki shine sa'o'i 1.9. An keɓe shi galibi tare da feces (60%) azaman metabolites. Kusan kashi 10-15% daga ƙodan ya keɓantar da su ta hanyar tsarin metabolites marasa aiki.

Contraindications

- gazawar hanta, cututtukan hanta mai saurin gaske, karuwa a cikin ayyukan hepatic transaminases na etiology, - porphyria, - myopathy, - kulawa na lokaci daya na ketoconazole, itraconazole, magunguna don lura da kamuwa da kwayar cutar HIV, - ƙwarewar jijiyoyin magungunan, da dama (inhibitors na HMG-CoA reductase) tarihin. taka tsantsan ya kamata a ba da magani ga marasa lafiya da cututtukan ƙwayar cuta, marasa lafiya bayan dasawar kwayoyin, waɗanda ake bi da su tare da magungunan immunosuppressive (saboda haɗarin haɗari na rhabdomyolysis da gazawar na koda), a cikin yanayin da zai iya haifar da gazawar renal mai ƙarfi, irin su hauhawar jini, matsananciyar cutar. mummunan cututtuka, mummunan metabolism da rikicewar endocrine, rikice-rikice a cikin ma'aunin ruwa-electrolyte, ayyukan tiyata (ciki har da hakori) ko raunin da ya faru ga marasa lafiya tare da rage ko ƙara yawan tone tone na kasusuwa na etiology da ba a sani ba, tare da cututtukan ƙwaƙwalwa, yara da matasa masu shekaru 18 (aminci da inganci ba a kafa su ba).

Umarnin don amfani

Tsarin saki, abun da aka shirya da marufiAllunan mai rufi hasken rawaya, m, convex, tare da daraja a gefe ɗaya da kuma rubutu "SIM 5" a ɗayan, a kan kink - fari.Fitowa: sitaci, lactose monohydrate, microcrystalline cellulose, butyl hydroxyanisole, ascorbic acid, citric acid monohydrate, magnesium stearate, hypromellose, talc, dioxide titanium, oxide baƙin ƙarfe 10 inji mai kwakwalwa. - blister (3) - fakitoci na kwali.Allunan mai rufi m ruwan hoda, m, convex, tare da daraja a gefe daya da kuma rubutu "SIM 10" a daya, a kan kink - fari.Fitowa: sitaci, lactose monohydrate, microcrystalline cellulose, butyl hydroxyanisole, ascorbic acid, citric acid monohydrate, magnesium stearate, hypromellose, talc, dioxide titanium, iron baƙin ƙarfe, baƙin ƙarfe baƙin ƙarfe 10 inji mai kwakwalwa. - blister (3) - fakitoci na kwali.Allunan mai rufi Orange mai haske, m, convex, tare da daraja a gefe guda da kuma rubutu "SIM 20" a daya, a kan kink - fari.Fitowa: sitaci, lactose monohydrate, microcrystalline cellulose, butyl hydroxyanisole, ascorbic acid, citric acid monohydrate, magnesium stearate, hypromellose, talc, dioxide titanium, iron baƙin ƙarfe, baƙin ƙarfe baƙin ƙarfe 10 inji mai kwakwalwa. - blister (3) - fakitoci na kwali.Allunan mai rufi fari ko kusan fararen fata, m, convex, tare da daraja a gefe guda da rubutu "SIM 30" a ɗayan, akan kink - fari.Fitowa: sitaci, lactose monohydrate, microcrystalline cellulose, butyl hydroxyanisole, ascorbic acid, citric acid monohydrate, magnesium stearate, hypromellose, talc, dioxide titanium 10 inji mai kwakwalwa. - blister (3) - fakitoci na kwali.Allunan mai rufi ruwan hoda, m, convex, tare da daraja a gefe ɗaya da rubutun "SIM 40" a ɗayan, a kan kink - fari.Fitowa: sitaci, lactose monohydrate, microcrystalline cellulose, butyl hydroxyanisole, ascorbic acid, citric acid monohydrate, magnesium stearate, hypromellose, talc, dioxide titanium, jan ƙarfe baƙin ƙarfe 10 inji mai kwakwalwa. - blister (3) - fakitoci na kwali.Clinical da kuma pharmacological kungiyar: Magungunan ƙwaƙwalwar ƙwayar cutaRajista No№:

Form sashi

Allunan mai rufe fim.

1 kwamfutar hannu mai rufe jiki ya ƙunshi:
Babbar kwamfutar hannu:abu mai aiki: simvastatin 5.00 mg / 10.00 mg / 20.00 mg / 30.00 mg / 40,00 mg magabata: Pregelatinized sitaci 10.00 mg / 20.00 mg / 40.00 mg / 60.00 mg / 80.00 mg, lactose monohydrate 47.60 mg / 95.20 mg / 190.00 mg / 286.00 mg / 381 , 00 mg, microcrystalline cellulose 5.00 mg / 10.00 mg / 20.00 mg / 30.00 mg / 40.00 mg, butylhydroxyanisole 0.01 mg / 0.02 mg / 0.04 mg / 0.06 mg / 0.08 mg, ascorbic acid 1.30 mg / 2.50 mg / 5.00 mg / 7.50 mg / 10.00 mg, citric acid monohydrate 0.63 mg / 1.30 mg / 2.50 mg / 3.80 mg / 5.00 mg, magnesium stearate 0.50 mg / 1.00 mg / 2.00 mg / 3.00 mg / 4.00 mg,
Harsashi: hypromellose-5 cps 0.35 mg / 0.70 mg / 1.50 mg / 2.00 mg / 3.00 mg, hypromellose-15 cps 0.53 mg / 1.10 mg / 2.30 mg / 3, 00 mg / 4.50 mg, talc 0.16 mg / 0.32 mg / 0.69 mg / 0.90 mg / 1.40 mg, titanium dioxide (E171) 0.40 mg / 0.80 mg / 1 , 70 mg / 2.30 mg / 3.4 mg, yellow iron oxide dye 0.0043 mg / 0.0017 mg / 0.11 mg / - / -, baƙin ƙarfe baƙin ƙarfe ja - / 0.0043 mg / 0.026 mg / - / 0.14 mg.

Bayanin

M, allunan biconvex, hotonda aka sanya fim, tare da daraja a gefe guda da zane a gefe guda, tare da haɗari biyu. Bango giciye fari ne.
Sashi 5 MG: allunan launi mai launin rawaya tare da zanen "SIM 5".
Sashi 10 MG: allunan launi ruwan hoda mai dauke da hoto "SIM 10".
Sashi na 20 MG: allunan hasken launi mai haske tare da zanen “SIM 20”.
Sashi na 30 MG: Allunan fararen fata ko kusan fararen launi tare da zanan "SIM 30".
Sashi 40 MG: allunan ruwan hoda tare da zanen “SIM 40”.

Yi amfani da lokacin daukar ciki da lokacin shayarwa

Yin amfani da miyagun ƙwayoyi SimvAGEXAL ® yayin daukar ciki yana contraindicated.
Sakamakon cewa HMG-CoA reductase inhibitors yana hana ayyukan cholesterol, da kuma cholesterol da sauran samfuran saututtukan sa suna taka rawa wajen haɓakar tayin, gami da haɗarin steroids da membranes cell, simvastatin na iya samun mummunar illa ga tayin idan aka yi amfani da mata masu juna biyu ( matan da suka isa haihuwa su guji daukar ciki). Idan ciki ya faru a lokacin jiyya, ya kamata a dakatar da miyagun ƙwayoyi, kuma ya kamata a faɗakar da mace game da haɗarin yiwuwar tayi.
Rage magunguna masu rage rage kiba a lokacin daukar ciki ba ya da wani tasiri a sakamakon gwajin magani na dogon lokaci na maganin hypercholesterolemia.
Babu bayanai game da sakin simvastatin a cikin madarar nono, don haka lokacin amfani da miyagun ƙwayoyi yayin shayarwa, ya kamata a dakatar da shayarwa.

Sashi da gudanarwa

Kafin fara magani tare da SimvAGEXAL ®, ya kamata a tsara mai haƙuri ta hanyar daidaitaccen tsarin cin abinci na hypocholesterolemic, wanda dole ne a bi shi tsawon lokacin kulawa.
Ana ɗaukar allunan SimvAGEXAL once sau ɗaya a rana, da maraice, da ruwa mai yawa.
Shawarar allurai na yau da kullum suna daga 5 zuwa 80 MG.
Ya kamata a zartar da hukunci a cikin tsaran makonni 4.
Za'a iya amfani da kashi 80 na MG kawai a cikin marasa lafiya tare da matsanancin hypercholisterinemia da haɗarin cutar zuciya.
Marasa lafiya tare da familial hyzycholesterolemia: maganin da aka ba da shawarar yau da kullun shine 40 MG kowace rana, sau ɗaya da maraice. Ana ba da shawarar kashi 80 na MG kowace rana idan kawai amfanin da aka yi amfani da shi ya wuce yuwuwar haɗarin. A cikin irin waɗannan marasa lafiya, ana amfani da miyagun ƙwayoyi SimvAGEXAL combination a hade tare da wasu hanyoyin aikin rage lipid (alal misali, LDL plasmapheresis) ko kuma ba tare da irin wannan magani ba, idan ba a same shi ba.
Marasa lafiya da cututtukan zuciya na ischemic ko babban haɗarin rikicewar zuciya
Ainihin matakin farko na SimvAGEXAL ® ga marasa lafiya da ke cikin hadarin kamuwa da cutar sankara a haɗe tare ko ba tare da hyperlipidemia ba (a gaban cutar sankarar mahaifa, tarihin bugun jini ko wasu cututtukan cerebrovascular, tarihin cutar cututtukan jijiyoyin hannu), har ma da marasa lafiya da cututtukan jijiyoyin zuciya sune 40 MG kowace rana .
Marasa lafiya tare da hyperlipidemia waɗanda ba su da abubuwan haɗarin da ke sama: Matsakaicin farawa shine 20 MG sau ɗaya kowace rana da maraice.
A cikin marasa lafiya tare da taro LDL taro wanda shine 45% mafi girma fiye da al'ada, kashi na farko na iya zama 40 mg / rana. Ga marasa lafiya masu laushi zuwa matsakaici zuwa matsakaici na hypercholesterolemia, ana iya farawa tare da SimvAGEXAL ® tare da farawa na 10 mg / rana.
Hadin kai da kai: Ana iya amfani da SimvAGEXAL ® duka a cikin maganin monotherapy kuma a hade tare da bin bile acid.
Ga marasa lafiya shan fibrates a lokaci guda, ban da fenofibrate, matsakaicin adadin kullun na simvastatin shine 10 MG. Amfani da kwanciyar hankali tare da gemfibrozil yana tazara.
A cikin marasa lafiya lokaci guda suna ɗaukar verapamil, diltiazem, da dronedarone, matsakaicin maganin yau da kullun shine 10 mg / rana.
Ga marasa lafiya lokaci guda suna ɗaukar amiodarone, amlodipine, ranolazine, matsakaicin adadin kullun na simvastatin shine 20 MG.
Marasa lafiya tare da gazawar na koda a cikin marasa lafiya da ke fama da rauni na aiki mai sauƙi zuwa ga matsakaici mai ƙarfi (CC fiye da 30 ml / min) daidaitawar kashi ba a buƙatar. A cikin marasa lafiya da ke fama da rauni na aiki mai ƙarancin ƙarfi (CC kasa da 30 ml / min) ko shan fibrates ko nicotinic acid (a kashi na fiye da 1 g / rana), kashi na farko shine 5 MG kuma mafi girman izinin kullun shine 10 MG.
A cikin tsofaffi marasa lafiya (fiye da 65 shekara) ba a bukatar daidaitawa da kashi.
Amfani a cikin yara da matasa 10-17 shekara tare da heterozygous familial hypercholesterolemia: An bayar da shawarar farawa shine 10 MG kowace rana da maraice. Jigilar maganin da aka ba da shawarar ita ce 10 - 40 MG a kowace rana, matsakaicin adadin maganin da aka ba da shawarar shi ne 40 MG kowace rana. Za'a zaɓi zaɓi ne daban-daban daidai da burin maganin warkarwa.
Idan aka rasa kashi na yanzu, ya kamata a sha magani kamar yadda ya kamata. Idan lokaci yayi da za a dauki kashi na gaba, bai kamata a ninka kashi biyu ba.

Side sakamako

A cewar Hukumar Lafiya ta Duniya (WHO), ana rarraba tasirin da ba a ke so gwargwadon yawan ci gaban su kamar haka: sau da yawa (≥1 / 10), sau da yawa (daga ≥1 / 100 zuwa rikicewar jini da tsarin lymphatic
da wuya: anemia (gami da haemolytic), thrombocytopenia, eosinophilia.
Rashin lafiyar tsarin juyayi
da wuya: farin ciki, ciwon kai, paresthesia, neuropathy na gefe,
da wuya tashin hankali na barci (rashin bacci, "mafarki mai ban tsoro"), bacin rai, asarar ƙwaƙwalwa ko rashi, hangen nesa.
Rashin lafiyar tsarin numfashi, kirji da gabobin jiki
galibi: Cutar huhu ta sama
ba a sani ba mita: cututtukan huhun ciki (musamman tare da amfani da tsawan lokaci), mashako, sinusitis.
Rashin lafiyar zuciya
galibi: atrial fibrillation.
Rashin narkewa
galibi: ciwan ciki
da wuya: maƙarƙashiya, ciwon ciki, tashin zuciya, amai, gudawa, zazzabin cizon sauro, farji.
Take hakkin hanta da kuma hanjin biliary
da wuya: hepatitis, jaundice,
da wuya mai rauni da gazawar hanta.
Rashin lafiyar fata da ƙananan ƙwayar cuta
da wuya: fata fatar, itching na fata, alopecia, photoensitivity.
Musculoskeletal da raunin nama
da wuya: myopathy * (ciki har da myositis), rhabdomyolysis (tare da ko ba tare da ci gaba da rashin lafiyar koda), myalgia, cramps muscle, polymyositis,
da wuya arthralgia, amosanin gabbai,
ba a sani ba mita: tendinopathy, mai yiwuwa tare da gurnin jijiya.
* A cikin nazarin asibiti, an lura da cutar myopathy a mafi yawan lokuta a cikin marasa lafiya da ke amfani da simvastatin a kashi 80 MG / rana, idan aka kwatanta da marasa lafiya suna amfani da kashi 20 mg / rana (1.0% idan aka kwatanta da 0.02%, bi da bi).
Take hakkin yara da hanji
ba a sani ba mita: m gazawar koda (saboda rhabdomyolysis), cututtukan urinary fili.
Take hakkin gabobi da mammary gland shine yake
ba a sani ba mita: erectile tabarbarewa, gynecomastia.
Janar cuta da rikice-rikice a wurin allurar
da wuya: janar gaba daya.
Allergic halayen
da wuya: angioedema, polymyalgia rheumatica, vasculitis, ƙara yawan erythrocyte sedimentation (ESR), ingantaccen dannars na rigakafin antinuclear, cututtukan fata na fata, lupus syndrome, dyspnea, malaise na gaba ɗaya, mita ba a sani ba: immuno-mediated necrotizing myopathy nealical syndrome ciki har da ciwo na Stevens-Johnson.
Labari da kayan aiki
da wuya: karuwar ayyukan “hanta” transaminases, CPK da alkaline phosphatase a cikin jini, ba a san mita ba: karuwar taro na glycosylated haemoglobin, hyperglycemia.
Lokacin amfani da wasu gumakan, waɗannan ƙarin abubuwan haɗari masu zuwa sun kasance masu rikodin:
• asarar ƙwaƙwalwa
• raunin hankali
• ciwon sukari mellitus. Mitar ci gaba da ciwon sukari ya dogara da kasancewar abubuwan haɗari (maida hankali kan yawan glucose na jini fiye da 5.6 mmol / l, ƙididdigar jiki na jiki fiye da 30 kg / m², ƙara yawan thyroglobulin (TG) a cikin jini na jini, tarihin hauhawar jini).
Yara da matasa (10-17 years old)
Dangane da binciken da ya dawwama shekara 1 a cikin yara da matasa (yara maza a cikin matakin Tanner II da sama da girlsan mata aƙalla shekara guda bayan haihuwar farko) waɗanda shekarunsu suka haɗu 10 zuwa 17 tare da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar iyali mai ƙarfi (n = 175), aminci da juriya bayanin martaba A cikin rukunin simvastatin, bayanin martabar kungiyar placebo ya yi kama.
Abubuwan da suka fi yawan rahoton haɗari sune cututtukan zuciya na sama, ciwon kai, zafin ciki, da tashin zuciya. Ba'a san amfanin dogon lokacin ci gaba na zahiri, hankali, da haɓakar jima'i. A yanzu (shekara guda bayan jiyya) babu isasshen bayanan tsaro.

Yawan abin sama da ya kamata

Zuwa yau, ba a gano takamaiman alamun alamun yawan ƙwayar cutar ƙwayoyi ba (mafi yawa na 3.6 g).
Jiyya: bayyanar cututtuka. Ba a san takamaiman maganin rigakafi ba.

Yin hulɗa tare da wasu kwayoyi

An gudanar da nazarin hulɗa tare da wasu kwayoyi ne kawai a cikin manya.
Hulɗa da Magunguna
Harkokin hulɗa tare da wasu magungunan rage ƙwayar lipid wanda zai iya haifar da haɗarin haɗarin kamuwa da cuta / rhabdomyolysis
Fibrates
Hadarin haɓaka myopathy, ciki har da rhabdomyolysis, yana ƙaruwa yayin amfani da simvastatin tare da fibrates lokaci guda.
Hada amfani da gemfibrozil yana haifar da karuwa a cikin ƙwayar plasma na simvastatin, don haka haɗuwa da aka haɗa sun haɗu.
Babu wata shaidar karuwar cutar myopathy tare da amfani da simvastatin lokaci daya kuma fenofibrate.
Nazarin Gudanarwa kan hulɗa tare da wasu zazzabi ba za'ayi ba.
Acid na Nicotinic
Akwai 'yan rahotanni na ci gaban myopathy / rhabdomyolysis tare da yin amfani da simvastatin da nicotinic acid a cikin ragewar rage ƙwayarwa (fiye da 1 g / rana).
Fusidic acid
Hadarin haɓakar myopathy yana ƙaruwa tare da yin amfani da fusidic acid lokaci guda tare da statins, gami da simvastatin. Idan ba zai yiwu ba saboda wasu dalilai don guje wa yin amfani da simvastatin tare da fusidic acid, yana da kyau kuyi tunanin jinkirta jiyya tare da simvastatin. Idan ya cancanta, amfani da su a lokaci guda, ya kamata a sanya marasa lafiya a kula sosai.
Abun hulɗa na Pharmacokinetic
Shawarwarin amfani da magungunan hulɗa ana ba su cikin tebur.

Hadin gwiwar Magunguna tare da Rara Hadarin Myopathy / Rhabdomyolysis

Sakamakon wasu kwayoyi a kan pharmacokinetics na simvastatin
Inarfin mai hana masu ƙarfi na isoenzyme CYP3A4
Simvastatin shine asalin CYP3A4 isoenzyme. Inarfin mai hana ƙarfi na CYP3A4 isoenzyme yana ƙara haɗarin cutar myopathy da rhabdomyolysis ta hanyar ƙara yawan inhibitory na HMG-CoA rage rage jini a cikin jini a lokacin jiyya tare da simvastatin. Irin waɗannan inhibitors sun haɗa da itraconazole, ketoconazole, posaconazole, voriconazole, erythromycin, clarithromycin, telithromycin, masu hana masu kariya na kwayar cutar HIV (misali nelfinavir), boceprevir, telaprevir, da kuma nefazodone.
Yin amfani da simvastatin tare da itraconazole, ketoconazole, posaconazole, erythromycin, clarithromycin, telithromycin, inhibitor na kwayar cutar ta HIV (misali nelfinavir), kazalika da nefazodone, yana contraindicated. Idan saboda wasu dalilai ba shi yiwuwa a guje wa yin amfani da simvastatin tare da magungunan da ke sama, to ya kamata a jinkirta jiyya tare da simvastatin har sai ƙarshen lokacin magani tare da waɗannan kwayoyi.
Ya kamata a yi amfani da Simvastatin tare da taka tsantsan tare da wasu ƙananan masu hana CYP3A4 mai hanawa: fluconazole, verapamil, ko diltiazem.
Fluconazole
An bayar da rahoton lokuta na rikicewar rhabdomyolysis da ke amfani da simvastatin da fluconazole na lokaci daya.
Sankarini
Amfani da cyclosporine da simvastatin lokaci guda ana hana su.
Danazole
Rashin haɓakar myopathy / rhabdomyolysis yana ƙaruwa tare da amfani da lokaci guda danazol, musamman tare da babban allurai na simvastatin.
Amiodarone
Hadarin haɓakar myopathy da rhabdomyolysis yana ƙaruwa tare da amiodarone na lokaci guda tare da babban allurai na simvastatin. A cikin bincike na asibiti, an gano ci gaban myopathy a cikin 6% na marasa lafiya waɗanda suka yi amfani da simvastatin a kashi 80 MG a haɗaka tare da amiodarone. Sabili da haka, kashi na simvastatin kada ya wuce 20 MG a rana a cikin marasa lafiya ta yin amfani da miyagun ƙwayoyi tare da amiodarone a lokaci guda, idan amfanin asibiti ya wuce haɗarin haɓakar myopathy da rhabdomyolysis.
Slow Calcium Channel Blockers
Verapamil
Hadarin haɓaka myopathy da rhabdomyolysis yana ƙaruwa tare da amfani da verapamil lokaci guda tare da simvastatin a cikin allurai mafi girma daga 40 MG. Yawan simvastatin kada ya wuce 10 MG a kowace rana a cikin marasa lafiya ta yin amfani da miyagun ƙwayoyi a lokaci guda tare da verapamil, idan amfanin asibiti ya wuce haɗarin haɓakar myopathy da rhabdomyolysis.
Diltiazem
Hadarin haɓakar myopathy da rhabdomyolysis yana ƙaruwa tare da yin amfani da diltiazem da simvastatin a lokaci guda na 80 MG. Tare da yin amfani da simvastatin na lokaci guda a cikin kashi 40 MG tare da diltiazem, haɗarin haɓaka myopathy bai karu ba. Yawan simvastatin kada ya wuce 10 MG a kowace rana a cikin marasa lafiya ta yin amfani da miyagun ƙwayoyi tare da diltiazem a lokaci guda, idan amfanin asibiti ya wuce haɗarin haɓakar myopathy / rhabdomyolysis.
Amlodipine
Marasa lafiya da ke amfani da amlodipine tare da simvastatin a kashi na 80 MG suna cikin haɗarin haɓakar ciwon sanyin mama. Tare da yin amfani da simvastatin na lokaci guda a cikin kashi 40 MG tare da amlodipine, haɗarin haɓaka myopathy bai karu ba. Tare da yin amfani da simvastatin tare da amlodipine, kashi na simvastatin bai wuce 20 MG kowace rana ba, idan amfanin asibiti ya wuce haɗarin haɓaka myopathy / rhabdomyolysis.
Lomitapid
Rashin haɓakar myopathy / rhabdomyolysis na iya ƙaruwa tare da yin amfani da lomitapide lokaci ɗaya tare da simvastatin.
Sauran ma'amala
Ruwan innabi
Ruwan innabi ya ƙunshi abubuwa guda ɗaya ko fiye waɗanda ke hana CYP3A4 isoenzyme kuma suna iya haɓaka ƙwayar plasma da kwayoyi ta metenolime ta CYP3A4 isoenzyme. Lokacin da shan ruwan 'ya'yan itace a cikin adadin da aka saba (gilashin 250 na ml a kowace rana), wannan tasirin yana da ƙima (haɓaka 13% a cikin ayyukan masu hana haɓaka HMG-CoA, ƙaddara ta yankin a ƙarƙashin ɓoye lokaci-lokaci) kuma ba shi da mahimmancin asibiti. Koyaya, amfani da ruwan 'ya'yan innabi a cikin manya-manyan kima (fiye da 1 lita kowace rana) yana haɓaka matakin plasma na aikin HMG-CoA reductase inhibitors yayin maganin tare da simvastatin. Dangane da wannan, ya zama dole don guje wa amfani da ruwan 'ya'yan itacen innabi a cikin manyan kima.
Colchicine
Akwai rahotanni na ci gaban myopathy / rhabdomyolysis tare da yin amfani da lokaci na colchicine da simvastatin a cikin marasa lafiya tare da gazawar renal. Marasa lafiya da ke amfani da waɗannan magunguna a lokaci guda ya kamata su kasance ƙarƙashin kulawar likita.
Rifampicin
Tun da rifampicin mai ƙarfi ne na CYP3A4 isoenzyme, a cikin marasa lafiya da ke shan wannan magani na dogon lokaci (alal misali, a cikin lura da cutar tarin fuka), ana iya samun ƙarancin inganci a cikin yin amfani da simvastatin (rashin cimma burin plasma cholesterol maida hankali).
Sakamakon simvastatin akan magunguna na sauran magunguna
Simvastatin baya hana CYP3A4 isoenzyme. Sabili da haka, ana tsammanin cewa simvastatin ba ya tasiri da ƙwayar ƙwayar plasma na abubuwan da ke haɗuwa da CYP3A4 isoenzyme.
Digoxin
Akwai saƙo wanda tare da yin amfani da digoxin da simvastatin sau ɗaya, yawan ƙwayar plasma na farko yana ƙaruwa kaɗan, sabili da haka, ya kamata a kula da marasa lafiya da digoxin, musamman a farkon aikin simvastatin.
Kai tsaye anticoagulants
A cikin gwaji na asibiti guda biyu, ɗayan wanda ya ƙunshi masu ba da agaji na lafiya da ɗayan da suka haɗa da marasa lafiya tare da hypercholesterolemia, simvastatin a cikin kashi 20-40 mg / day a haɓaka tasirin maganin ƙwayoyin cuta na coumarin Matsakaicin ƙimar kasa da kasa (INR) ya karu daga 1.7-1.8 zuwa 2.6-3.4 a cikin masu sa kai da marasa lafiya, bi da bi. A cikin marasa lafiya da ke amfani da maganin anticoagulants na coumarin, prothrombin lokaci (PV) ko INR ya kamata a ƙaddara su kafin magani kuma, bayan haka, sau da yawa ana ƙaddara a matakin farko na magani tare da simvastatin don tabbatar da cewa babu manyan canje-canje a cikin PV / INR. Da zarar an tabbatar da ƙayyadaddun ƙwayar PV / INR, za a iya saka idanu akan tsaka-tsakin lokaci da aka ba da shawarar ga marasa lafiya da ke shan magungunan coumarin anticoagulants. Tare da canji a cikin adadin simvastatin, ko katsewa na jiyya, ya kamata a kara yawan sarrafa PV / INR. Abinda ya faru na zub da jini ko canji a cikin PV / INR a cikin marasa lafiya marasa amfani da maganin anticoagulants ba shi da alaƙa da amfani da simvastatin.

Simvagexal: ka ce a'a ga cholesterol mai yawa

imvaghexal magani ne wanda ya danganta da simvastatin.

Ana amfani dashi don kula da marasa lafiya da cututtukan zuciya da cututtukan zuciya da hypercholesterolemia.

An wajabta shi ga marasa lafiya waɗanda shekarunsu suka wuce goma sha takwas, ban da mutanen da ke ɗauke da maganin cuta.

Simvagexal kantin sayar da magani ne. Sabili da haka, kafin siyan magani, ya kamata ka nemi likita.

Tsarin aikace-aikace

Simauki Simvagexal a ciki, sannan a sha ruwa mai yawa. Yawan amfani - sau ɗaya a rana. Lokacin da aka fi so don shigowa shine maraice. An ƙayyade tsawon lokacin jiyya daban daban.

Idan an rasa kashi na yanzu, ana ɗaukar magani nan da nan. Koyaya, kar a ninka kashi biyu idan lokaci yayi na gaba.

Matsayi na farko don lura da hypercholesterolemia an ƙaddara shi da tsananin cutar kuma ya bambanta daga 5 zuwa 10 MG / rana. An saita maganin ne gwargwadon matakin plasma na cholesterol da aka samu tare da tazara tsakanin akalla makonni huɗu.

Daidaitaccen maganin yau da kullun shine 40 mg. Idan mai haƙuri yana da haɗarin zuciya da jiyya kuma ba shi da isasshen magani, likita na iya ƙara yawan kashi zuwa 80 MG / rana.

Maganin farko na CHD shine 20 MG. Idan ya cancanta, ƙara zuwa 40 MG kowane mako huɗu. Adadin maganin yana ragewa idan jimlar cholesterol ta faɗi ƙasa da 3.6 mmol / lita, kuma abun LDL yana ƙasa da 1.94 mmol / lita.

Marasa lafiya a lokaci guda suna ɗaukar cyclosporine, nicotinamide ko fibrates suna buƙatar rage farawa da matsakaiciyar maganin yau da kullun zuwa 5 da 10 mg, bi da bi. Haka yake ga mutanen da ke fama da matsalar koda.

Abinda aka bada shawarar farko da mafi girman allurai na yau da kullun don maganin immunosuppressive shine 5 mg / day.

3. Abun ciki, sakin saki

Magungunan sun ƙunshi simvastatin da ƙarin abubuwa, kamar su lactose monohydrate, ascorbic acid, magnesium stearate, talc, iron (III) oxide, sitaci masara, hypromellose, citric acid monohydrate, acid dioxide, MCC.

An saki Simvagexal a cikin nau'ikan allunan convex mai launi tare da notched, mai rufi mai rufi.

Launin harsashi na iya zama launin rawaya (5 MG), ruwan hoda mai haske (10 MG), Orange mai haske (20 MG), farin ko kusan fari (30 MG), da ruwan hoda (40 MG). A gefe ɗaya na allunan akwai rubutu "SIM 40", "SIM 30", "SIM 10", "SIM 20" ko "SIM 5" (ya danganta da sakin saki).

5. Rashin sakamako

A lokacin daukar ciki

Marasa lafiya masu juna biyu kada su dauki Simvagexal. Akwai rahotanni na ci gaba a cikin jarirai waɗanda uwayensu sun dauki simvastatin na mahaukata daban-daban.

Idan mace mai yawan haihuwa ta dauki simvastatin, to ya kamata ta guje wa juna biyu. Idan ciki ya faru a lokacin jiyya, ya kamata a dakatar da Simvagexal, kuma ya kamata a faɗakar da mai haƙuri game da yiwuwar barazanar tayin.

Babu wani bayani game da rarraba bangaren da ke aiki tare da madara. Idan har ba za ku iya guje wa sanya Simvagexal wa mace mai ciki ba, to ya kamata ku tunatar da ita game da bukatar dakatar da shayarwa.

Wannan rigakafin yana da alaƙa da gaskiyar cewa yawancin magunguna suna keɓantattu a cikin madara, suna ƙaruwa da haɓakar ƙarancin halayen.

7. Sharuɗɗa da yanayin ajiya

Ana adana Simvagexal na shekaru uku a zazzabi na har zuwa digiri 30 ko daidai yake da shi.

Matsakaicin farashin simvageksal a cikin kantin magunguna na Rasha ne 280 p.

Zuwa ga mutane daga Ukraine miyagun ƙwayoyi yana kashe kimanin UH ​​300.

Jerin samfuran analogues na Simvagexal sun hada da irin waɗannan magunguna kamar Aterostat, Avestatin, Vazilip, Actalipid, Zokor, Vero-Simvastatin, Zorstat, Zovatin, Ariescor, Simvastatin, Simgal, Simvor, Simvastol, Holvasim, Sinkard, Simplakor da sauransu.

Yin bita game da magani tsakanin likitoci da marasa lafiya galibi abin yarda ne. A cewar su, simvagexal yana taimakawa rage cholesterol da kuma haɗarin rikice-rikice masu alaƙa da aikin ƙwaƙwalwar zuciya.

Je ƙarshen labarin don karanta sake dubawa game da Simvageksal. Bayyana ra'ayinka game da miyagun ƙwayoyi idan dole ne ka sha shi ko ka tsara shi ga marasa lafiya. Wannan zai taimaka wa sauran baƙi shafin.

1. A farkon shan miyagun ƙwayoyi, serum transaminase mai yiwuwa ne (karuwar jigilar lokaci a matakin hanta enzymes).
2. Ba a ɗaukar cutar Simvagexal cikin haɗarin haɗari na haɓaka irin wannan cututtukan kamar rashin cin nasara na yara, rhabdomyolysis.

Sivastatin, an wajabta wa marassa lafiya na ciki, na iya yin illa ga tayin (matan da shekarun haihuwa ya kamata su guji ɗaukar ciki). Idan ciki ya faru a lokacin jiyya, ya kamata a dakatar da maganin, kuma ya kamata a sanar da mara lafiyar na iya barazanar tayin.

Shin labarin ya taimaka? Wataƙila wannan bayanin zai taimaka wa abokanka! Da fatan za a danna ɗaya daga cikin maɓallinan:

Sunan kasa da kasa mai zaman kansa:

Allunan mai rufe fim.

1 kwamfutar hannu mai rufe jiki ya ƙunshi:
Tablet core: sashi mai aiki: simvastatin 5.00 mg / 10.00 mg / 20.00 mg / 30.00 mg / 40,00 mg, abubuwan da suka gabata: pregelatinized sitaci 10.00 mg / 20.00 mg / 40.00 mg / 60.00 mg / 80.00 mg, lactose monohydrate 47.60 mg / 95.20 mg / 190.00 mg / 286.00 mg / 381.00 mg, microcrystalline cellulose 5.00 mg / 10.00 mg / 20.00 mg / 30.00 mg / 40.00 mg, butylhydroxyanisole 0.01 mg / 0.02 mg / 0.04 mg / 0.06 mg / 0.08 mg, ascorbic acid 1.30 mg / 2 , 50 mg / 5.00 mg / 7.50 mg / 10.00 mg, citric acid monohydrate 0.63 mg / 1.30 mg / 2.50 mg / 3.80 mg / 5.00 mg, magnesium stearate 0 50 mg / 1.00 mg / 2.00 mg / 3.00 mg / 4.00 mg
Harsashi: hypromellose-5 cps 0.35 mg / 0.70 mg / 1.50 mg / 2.00 mg / 3.00 mg, hypromellose-15 cps 0.53 mg / 1.10 mg / 2.30 mg / 3.00 mg / 4.50 mg, talc 0.16 mg / 0.32 mg / 0.69 mg / 0.90 mg / 1.40 mg, titanium dioxide (E171) 0.40 mg / 0.80 mg / 1.70 mg / 2.30 mg / 3.4 mg, yellow iron oxide dye 0.0043 mg / 0.0017 mg / 0.11 mg / - / -, baƙin ƙarfe baƙin ƙarfe ja - / 0.0043 mg / 0.026 mg / - / 0.14 mg.

Bayanin

M, allunan biconvex, hotonda aka sanya fim, tare da daraja a gefe guda da zane a gefe guda, tare da haɗari biyu. Bango giciye fari ne.
Sashi 5 MG: allunan launi mai launin rawaya tare da zanen "SIM 5".

Sashi 10 MG: allunan launi ruwan hoda mai dauke da hoto "SIM 10".
Sashi na 20 MG: allunan hasken launi mai haske tare da zanen “SIM 20”.
Sashi na 30 MG: Allunan fararen fata ko kusan fararen launi tare da zanan "SIM 30".

Sashi 40 MG: allunan ruwan hoda tare da zanen “SIM 40”.