Rosinsulin R, C da M - taƙaitaccen halaye da umarnin don amfani

Pharmacodynamics

Rinsulin P shine insulin ɗan adam ta hanyar amfani da fasahar DNA. Short insulin. Yana hulɗa tare da takamaiman mai karɓa akan ƙwayar cytoplasmic na waje na sel kuma yana samar da hadaddun insulin-receptor wanda ke motsa ayyukan ciki, gami da haɗakar enzymes da yawa (hexokinase, pyruvate kinase, glycogen synthase, da sauransu). Rage yawan glucose na jini ana faruwa ne ta hanyar karuwa a cikin jijiyoyin zuciya, karuwar sha da kuma rage kyallen takarda, haɓakar lipogenesis, glycogenogenesis, raguwa a cikin yawan samar da glucose ta hanta, da dai sauransu.
Tsawon lokacin aiwatar da shirye-shiryen insulin ya kasance ne sabili da yawan rashi, wanda ya dogara da abubuwa da yawa (alal misali, akan kashi, hanyar da wurin gudanarwar), sabili da haka bayanin aikin insulin yana haifar da sauyawa sosai, duka mutane daban-daban kuma iri daya mutum. Matsakaici, bayan subcutaneous management, Rinsulin P ya fara aiki bayan minti 30, matsakaicin sakamako yana haɓaka tsakanin 1 zuwa 3, tsawon lokacin aikin shine 8 hours.

Pharmacokinetics
Kammalawar shan ruwa da farawa daga cikin sakamako na insulin ya dogara da hanyar gudanarwa (subcutaneously, intramuscularly, intravenously), wurin gudanarwa (ciki, cinya, buttocks), kashi (girman insulin allurar), maida hankali na insulin a cikin magunguna, da dai sauransu Ana rarrabe shi ba a daidaita ba a tsakanin kyallen kuma ba ya ratsa ta cikin kyallen kuma ba ya ratsa ta shinge yana fitowa daga madara. An lalata shi ta hanyar insulinase galibi a cikin hanta da kodan. Cire rabin rayuwar yayi wasu mintuna. Kodan ya fitar da ita (kashi 30-80%).

Alamu don amfani

• Type 1 ciwon sukari
• Type 2 ciwon sukari mellitus: mataki na jure wa baki hypoglycemic jamiái, m jure wadannan kwayoyi (yayin hade far), intercurrent cututtuka
• Buga na 2 ciwon sukari a cikin mata masu juna biyu
• Yanayin gaggawa a cikin marasa lafiya da ciwon sukari mellitus tare da decompensation na carbohydrate metabolism

Sashi da gudanarwa

Jadawalin tsari da hanyar gudanarwa

Magungunan an yi niyya ne don gudanar da aiki da jijiyoyin jiki da na ciki.
Adadin da hanyar gudanar da maganin an yanke ta ta likita daban-daban a cikin kowane yanayi dangane da maida hankali na glucose a cikin jini.
A matsakaici, kashi na yau da kullum na miyagun ƙwayoyi ya tashi daga 0.5 zuwa 1 IU / kg nauyin jikin mutum (ya dogara da yanayin halayen mutum na haƙuri da haɗuwa da glucose jini).
Ana gudanar da maganin a cikin mintina 30 kafin cin abinci ko abun ciye-ciye wanda ya ƙunshi carbohydrates.
Zazzabi na insulin da ke cikin yakamata ya zama zazzabi a dakin. Tare da monotherapy tare da magani, yawan gudanarwa sau 3 a rana (idan ya cancanta, har zuwa 5-6 sau a rana). A cikin maganin yau da kullun ya wuce 0.6 IU / kg, dole ne a gudanar da maganin a cikin nau'in 2 ko fiye da injections a cikin bangarori daban-daban na jiki. Yawancin lokaci miyagun ƙwayoyi suna cikin allurar ciki a cikin bangon ciki na ciki. Hakanan za'a iya yin allura a cinya, ko kuma kafada ko kafada a cikin tsinkayar jijiyar wuya.
Wajibi ne a canza wurin allurar a cikin yankin na jiki don hana ci gaban lipo-dystrophy. Tare da yin aiki da insulin ƙasa na insulin, dole ne a kula da kar a shigar da jini lokacin allura. Bayan allurar, bai kamata a sanyaya wurin da allura ba. Yakamata a horar da marassa lafiya yadda yakamata ayi amfani da na’urar insulin.
Za'a iya gudanar da maganin ta hanyar intrauscularly da na ciki, kawai a karkashin kulawa na likita.
Za'a iya amfani da vials idan abubuwan da suke ciki sune tsabtataccen ruwa mara launi ba tare da barbashi bayyane ba. Ba za ku iya amfani da miyagun ƙwayoyi ba idan hazo ya bayyana a cikin mafita. Rinsulin ® P shine insulin aiki gajere kuma yawanci ana amfani dashi a hade tare da insulin na matsakaici (Rinsulin ® NPH).
Zai yuwu a adana magani a cikin amfani a zazzabi a ɗakin (daga 15 zuwa 25 ° C) ba fiye da kwanaki 28 ba.

Side sakamako

Sakamakon sakamako akan metabolism metabolism: yanayin hypoglycemic (pallor na fata, karuwar gumi, palpitations, rawar jiki, jin sanyi, yunwa, tashin hankali, paresthesia na mucosa na baka, rauni, ciwon kai, tsananin farin ciki, raguwar jijiyoyin gani). Mai tsananin rashin ƙarfi na hypoglycemia na iya haifar da haɓakar ƙwaƙwalwar ƙwayar cuta.
Allergic halayen: rash fata, fitsarin Quincke, girgiza ƙwayoyin cuta.
Ayyukan gida: hyperemia, kumburi da itching a wurin allurar, tare da tsawan amfani - lipodystrophy a wurin allurar.
Sauran: edema, raguwar jinkirin gani na acuity na gani (yawanci a farkon farfajiya).
Idan mai haƙuri ya lura da haɓakar haɓakawar jini ko kuma ya sami asarar hankali, yana buƙatar sanar da likita nan da nan.
Idan an gano duk wasu sakamako masu illa da aka ambata a sama, mai haƙuri ya kamata ka kuma nemi likita.

Umarni na musamman

Kariya don amfani

A waje da tushen ilimin insulin, kulawa akai-akai na maida hankali kan glucose jini yana da muhimmanci.
Abubuwan da ke haifar da hauhawar jini a cikin ƙari ga yawan yin insulin na iya zama: maye gurbin miyagun ƙwayoyi, tsallake abinci, amai, gudawa, haɓaka aiki na jiki, cututtukan da ke rage buƙatar insulin (lalacewar hanta da ƙwayar koda, hauhawar ƙwayar fata adrenal, pituitary ko glandar thyroid), canjin wurin allura, kazalika da ma'amala da wasu magunguna.
Rashin ingantaccen allura ko katsewa a cikin gudanarwar insulin, musamman a cikin marasa lafiya da ke dauke da ciwon sukari na 1, na iya haifar da cutar hauka. Yawancin lokaci alamun farko na hyperglycemia suna haɓaka hankali a kan sa'o'i da yawa ko kwanaki. Waɗannan sun haɗa da ƙishirwa, yawan urination, tashin zuciya, amai, amai, ja, bushewar fata, bushewar baki, rashin ci, kamshin acetone a cikin iska mai ƙuna. Idan ba a kula da shi ba, zazzabin hyperglycemia a cikin nau'in 1 na ciwon sukari na iya haifar da haɓakar cutar ketoacidosis mai barazanar rayuwa.
Yankin insulin dole ne a gyara shi saboda aikin thyroid mai rauni, cututtukan Addison, cututtukan zuciya, hanta da ƙoshin koda da kuma ciwon sukari a cikin mutane sama da shekaru 65 da haihuwa.
Hakanan ana iya buƙatar gyara kashi na insulin idan mai haƙuri ya ƙaru da ƙarfin motsa jiki ko ya canza abincin da aka saba.
Cututtukan da ke haɗuwa, musamman cututtuka da yanayi tare da zazzabi, suna ƙara buƙatar insulin.
Canja wurin mara lafiya zuwa wani sabon nau'in insulin ko shirin insulin na wani kamfanin dole ne a aiwatar dashi karkashin kulawar likita.
Sakamakon yiwuwar hazo a cikin wasu catheters, ba a bada shawarar yin amfani da miyagun ƙwayoyi a cikin farashin matatun.

Tasiri kan iya tuka motoci da injinan

Dangane da ainihin manufar insulin, canji a nau'inta, ko kasancewar mahimman damuwa na jiki ko na tunani, zai iya lalata ikon fitar da motoci ko hanyoyin motsawa daban-daban, kazalika da shiga cikin wasu ayyukan masu haɗari waɗanda ke buƙatar ƙara kulawa da saurin hanzartawa.

Mai masana'anta

Adreshin wuraren samarwa:

1. 142279, Yankin Moscow, gundumar Serpukhov, r.p. Obolensk, gini 82, shafi 4.
2. 142279, yankin Moscow, gundumar Serpukhov, pos. Obolensk, gini 83, lit. AAN.

GEROPHARM-Bio OJSC
142279, Yankin Moscow, gundumar Serpukhov, r.p. Obolensk, gini 82, shafi. 4

Umarnin da za a bai wa mai haƙuri

Ba za ku iya amfani da miyagun ƙwayoyi ba idan hazo ya bayyana a cikin mafita.
Hanyar allura don insulin a cikin vials

Idan mara lafiyar yana amfani da nau'in insulin guda ɗaya kaɗai

1. Sanitize da roba ƙwayar na vial
2. Zana iska a cikin sirinji a cikin girman yayi daidai da adadin insulin da ake so. Sanya iska a cikin murfin insulin.
3. Juya murfin tare da sirinji a gefe kuma zana adadin insulin da ake so a cikin sirinji. Cire allura daga vial kuma cire iska daga sirinji. Binciko idan maganin insulin yayi daidai.
4. Cike kai tsaye.

1. Sanyeze da roba membranes na vials.
2. Nan da nan kafin yin bugawa, mirgine murfin insulin aiki (“girgije”) tsakanin tafin hannunka har lokacin insulin ya zama fari da gajimare.
3. Airara iska a cikin sirinji a cikin ƙarar daidai da kashi na insulin na girgije. Sanya iska a cikin murfin insulin na girgije kuma cire allura daga cikin murfin.
4. Zana iska a cikin sirinji a cikin adadin da yayi daidai da adadin insulin-ɗan gajeran aiki (“m”). Sanya iska a cikin kwalban insulin insulin. Juya kwalban tare da sirinji a sama kuma buga lambar da ake so na insulin "bayyananne". Cire allurar kuma cire iska daga sirinji. Duba daidai gwargwado.
5. Saka allura cikin murfin tare da insulin '' hadari '', kunna murfin tare da sirinji na sama kuma a buga ƙurar insulin da ake so. Cire iska daga sirinji ka bincika ko kaɗaicin yayi daidai. Sanya cakuda insulin da aka tara nan da nan.
6. Koyaushe yi insulin a cikin jeri ɗaya kamar yadda aka bayyana a sama.

• Wajibi ne don magance yankin fata inda za a allurar da insulin.
• Tare da yatsunsu biyu, tattara daɗa fata, saka allura a cikin gindin murfin a wani kusurwa na kimanin digiri 45, kuma saka allurar a ƙarƙashin fata.
• Bayan allura, allura ya kamata ya kasance a karkashin fata na akalla awanni 6, don tabbatar da cewa an saka insulin gaba daya.
• Idan jini ya bayyana a wurin allura bayan cire allura, a hankali shafa matattar allurar tare da kwantar da hancin tare da maganin mafitsara (kamar giya).
• Wajibi ne don canja wurin allurar.

Babban bayani

An shirya maganin don rage taro na sukari. Babban abincinta shine insulin mutum.

Baya ga shi, abun da ya hada magungunan ya hada da:

Rosinsulin yana samuwa azaman allura. Yana da launi mara launi da kamshi.

A miyagun ƙwayoyi yana da yawa iri:

1. P - ana nuna shi da sifar bayyanar.
2. C - aikinta na matsakaici ne.
3. M - wani suna - hade Rosinsulin 30-70. Ya haɗu da abubuwa biyu: insulin mai narkewa (30%) da insulin insalin (70%).

Game da wannan, magungunan da aka jera suna da wasu bambance-bambance, kodayake a gaba ɗaya tsarin aikinsu ɗaya ne.

Yakamata a yi amfani da maganin kamar yadda likita ya umarta, tunda daga shi ne kawai zaka iya samun ingantattun umarnin. Idan ba tare da shi ba, wannan magungunan na iya zama haɗari har ma ga waɗancan marasa lafiya waɗanda aka nuna musu.

Formaddamar da tsari da abun da ke ciki

"Rosinsulin" yana nufin magungunan cututtukan zuciya. Ya danganta da saurin bayyanar ƙwayoyi da tsawon lokaci, akwai:

• "Rosinsulin S" yana nufin magungunan matsakaici,
• "Rosinsulin R" - gajeriyar hanya,
• Rosinsulin M shiri ne mai hade.

Magunguna insulin ne, ana samun shi ne kawai daga jikin mutum ta hanyar canje-canje na DNA. Kamar yadda aka fada a cikin umarnin don amfani da Rosinsulin C, ƙa'idar aiki ta samo asali ne daga hulɗa da babban ɓangaren magungunan tare da sel. A sakamakon wannan, an kafa hadaddun insulin.

Maganin yana dakatarwa da aka shirya don gudanar da aikin subcutaneous. Sakamakonsa shine yafi dacewa saboda abubuwan insulin-isophan a cikin abun da ke ciki. Wannan farin magani ne tare da ɗan ƙaramin launin toka mai kauri. Idan kuwa ba ta girgiza ba, to ana rarraba shi a kan tsaftataccen ruwa da laka. Abin da ya sa bisa ga umarnin, kafin gabatarwar maganin kana buƙatar girgiza kaɗan.

Wannan magani yana da kyawawan farashi mai kyau. Umarnin don amfani da "Rosinsulin R" yana ba da shawarar cewa wannan kayan aikin insulin ne mai narkewa gajere. Yana hulɗa da sauƙi sosai tare da mai karɓa na musamman akan membrane, yayin samar da hadadden insulin receptor.

Yayin jiyya tare da wannan magani, ƙwayar glucose a cikin ƙwayoyin mai da hanta yana ƙaruwa. Babban abubuwanda ke shiga cikin ƙwayoyin tsoka, yana ƙarfafa ayyukan aiwatar hanyoyin cikin ciki.

Saboda karuwar kwayar sunadarai, yawan glucose a cikin jini da rushewar glycogen zai ragu. Bayan allura, sakamako na warkewa yana farawa tsakanin minti 30. Tsawon lokacin aiwatarwa daga kashi ɗaya shine kusan awowi 8. Darajar sun dogara da sashi, hanya da yankin gudanarwa.

An gabatar da magani "Rosinsulin C" a cikin nau'i na isophane tare da matsakaicin tsawon lokacin aiki. Magungunan yana taimakawa rage yawan glucose a cikin jini, yana ƙara shanshi ta hanyar kyallen takarda. Wannan yana rage yawan samarda glucose ta hanta. Bayan gabatarwar miyagun ƙwayoyi, sashin warkewa yana fara aiki a cikin sa'o'i 2. Ana samun mafi girman sakamakon bayan awa 12. Sakamakon warkewa yana kwana ɗaya.

Wanene aka sanya

Kafin fara magani, umarnin don amfani da bayanin “Rosinsulin S” dole ne a yi nazari don sanin ainihin abin da aka sanya maganin da kuma yadda za a yi amfani da shi daidai. Tabbatar tuntuɓar likita, ya wajaba don sanin dacewar amfaninsa. An hana shi cin gashin kansa da amfani dashi, tunda akwai yiwuwar mummunan sakamako. Likitocin sun bada shawarar shan maganin a gaban ire-iren cututtukan kamar:

• nau'in 1 da nau'in ciwon sukari na 2
• ciwon suga yayin daukar ciki
• a cikin bayan aiki ko bayan aikin.

Bugu da ƙari, an tsara wannan maganin idan babu sakamakon sakamako daga shan wasu magungunan cututtukan ƙwayar cuta, kazalika ban da babban maganin.

Magunguna

Dangane da umarnin don amfani, “Rosinsulin C” yana nufin shirye-shiryen da akayi nufin gudanarwa ƙarƙashin fata. An zabi sashi ne don la'akari da ganewar asali da kuma matakin glucose a cikin jini. Kafin fara magani, kuna buƙatar ziyarci likita don ƙididdige tsarin kulawa. Matsakaicin shawarar sashi ya dogara da irin maganin. 1 ml na dakatarwa ya ƙunshi har zuwa 100 IU.

Dangane da umarnin don amfani, an wajabta Rosinsulin M a cikin sashi na 0.5-1 IU a kowace kilogiram na nauyin haƙuri. Bayan haka, ana nazarin halayen halayen jini da glucose, kuma an zaɓi ingantaccen sashi.

Kamar yadda aka fada a cikin umarnin don amfani, "an tsara Rosinsulin R" a raka'a 40 a kowace rana. Hanyar gudanarwa ta dogara ne da ƙididdigar jini kafin abinci da kuma bayan abincin. Ana iya gudanar da maganin:

• takarkari
• intramuscularly
• cikin intravenally.

Mafi sau da yawa, ana gudanar da Rosinsulin R a ƙarƙashin ƙasa. Idan an kamu da cutar sikila ko kuma aka nuna masa tiyata, ana gudanar da maganin ne ta intramuscularly ko a cikin jijiya. Tare da monotherapy, ana amfani da miyagun ƙwayoyi sau 3 a rana. A wasu halaye, yawan tafiyar da miyagun ƙwayoyi ya kai har sau shida a rana. Don kauce wa lipodystrophy da atrophy, shafin allurar yana buƙatar canzawa kowane lokaci.

Dangane da umarnin don amfani, an wajabta Rosinsulin S a cikin sashi na ƙimar bai wuce 24 IU ba. Ana gudanar da maganin a cikin sau 1-2 a rana subcutaneously. Maƙerin ya ba da shawarar canza wurin allura a kowane lokaci. Ana shan miyagun ƙwayoyi minti 30 kafin karin kumallo. A wasu halaye, an wajabta mai haƙuri ta allura, kuma an hana gudanar da aikin cikin jijiya.

Kafin amfani da maganin, kuna buƙatar dumama shi zuwa zafin jiki na ɗakin.Hakanan kuna buƙatar girgiza kwalban don ƙarin ko da magunguna. Matsayin gudanarwa yana ƙaddara ta likita. Wannan galibi bangon ciki ne, cinya, kafada ko kafa.

A cikin daidaitattun yanayi, bisa ga umarnin don amfani, an wajabta Rosinsulin N don 8-24 IU sau ɗaya a rana. Idan mai haƙuri yana da ƙarfin jiyya ga insulin, to, an tsara maganin a cikin mafi ƙarancin magani, kuma tare da rage ji na ƙwarai, kashi ya fi 24 IU kowace rana.

Ciki

Kamar yadda aka fada a cikin umarnin don amfani, Rosinsulin C a lokacin daukar ciki da shayarwa ana iya amfani dashi don magani, tunda abubuwan da ke aiki ba su shiga cikin mahaifa.

Kafin shirin daukar ciki, ana bada shawara don bincika jini don abubuwan sukari. Idan akwai alamun ƙara, likita ya tsara Rosinsulin. Lokacin shayar da nono, an ba shi izinin amfani da wannan maganin, tunda babu wani bayani game da shigar da shi cikin madara.

Yi amfani da ƙuruciya da tsufa

Ana iya amfani da "Rosinsulin" don bi da yara, duk da haka, kuna buƙatar daidaita sashi. Hakanan yana da mahimmanci a kula da matsayin lafiyar da kuma shaidar.

An ba da izinin magani don kula da tsofaffi, amma dole ne a yi amfani da shi sosai, tun da suna da haɗarin mafi girma na haɓakar haɓaka da haɓaka sauran cututtukan haɗin gwiwa.

Contraindications

Kafin amfani da maganin, ya wajaba a bincika umarnin don amfani da "Rosinsulin C". Farashin miyagun ƙwayoyi ya kai 926 rubles. An haramta yin amfani da shi ba tare da neman likita ba. Wannan na faruwa ne sakamakon yiwuwar faduwar glucose zuwa dabi'u masu mahimmanci.

Don hana haɓakar rikice-rikice, kuna buƙatar bin umarnin a fili, kuma ku ɗauki contraindications. An haramta yin amfani da wannan kayan aiki a gaban bayyanarwar rashin damuwa ga abubuwan da ke cikin miyagun ƙwayoyi, har ma a cikin yanayin sukari mai ƙarancin jini.

Side effects

Amfani da "Rosinsulin" mara kyau yana tattare da sakamako masu illa ga jiki. Don yin wannan, ana bada shawara cewa ku bi magunguna na likita a sarari, kada ku yi canje-canje ga tsarin sake kula da kanku. Matsaloli masu yuwuwar hanya sune:

• zuciya tashin hankali,
• fata rashes,
• pallor
• ciwon kai
• busawa da konewa a wurin allurar,
• magudanar jini.

Idan mummunan halayen ya faru, dole ne koyaushe ka nemi likita don daidaita ilimin.

Hulɗa da ƙwayoyi

Magungunan "Rosinsulin" ya dace da kulawa mai rikitarwa tare da sauran magunguna. Kafin fara haɗuwa da magani, kuna buƙatar tuntuɓi likita. Zai yi alƙawari, ka kuma ƙididdige sashi, yin la'akari da ma'amala da abubuwan haɗin abubuwa masu aiki.

Tare da taka tsantsan, kuna buƙatar ɗaukar "Rosinsulin" tare da wasu hanyoyi waɗanda aka yi niyya don daidaita matakan glucose na jini. Ragewar sakamakon da ake so ana lura dashi tare da gudanar da kulawa na lokaci daya tare da diuretics, hana haihuwa, maganin cututtukan fata.

Analogues na miyagun ƙwayoyi

Kafin sayen magani, kuna buƙatar yin nazarin umarnin don amfani da sake dubawa game da "Rosinsulin" Farashin magungunan kusan 100 rubles. Yana da magunguna masu kama da yawa waɗanda aka wajabta su idan akwai magungunan ƙwayoyin cuta. Daga cikin analogues, ya zama dole a nuna kamar:

Magungunan "Novomix" insulin kashi biyu ne. An rarrabe ta da sauri da kuma tasiri. Ba a ba da izini ga yara 'yan ƙasa da shekara shida ba. Sau da yawa a wurin allura, rashin lafiyan yakan faru.

Magungunan "Insuman" nau'ikan aikin 3. Ana amfani dashi don maganin yara da manya. Wannan kayan aiki da wuya tsokani ya haifar da sakamako masu illa.

Ana amfani da maganin "Protafan" ne kawai a ƙarƙashin ƙasa, ana amfani dashi don kula da marasa lafiya na kowane zamani. Ana iya amfani da shi ta hanyar mata masu juna biyu da kuma lokacin shayarwa.

Likita shawara

Likitocin sun ce yayin haihuwa da kuma bayan haihuwa, bukatar insulin ya ragu sosai. A wannan yanayin, dole ne mace ta kasance karkashin kulawar likitoci. Likitoci sun ce wannan magani yana da sakamako mai kyau tare da amfani da kullun.

Suna jayayya cewa wannan maganin ba shi da maganin hana kwantar da hankali idan ana amfani da shi daidai.

Neman Masu haƙuri

Nazarin masu ciwon sukari tare da gwaninta akan wannan magani galibi tabbatacce ne. Sun lura da dacewa da amfani, ikon hada nau'ikan insulin. Koyaya, akwai mutanen da waɗanda ba su dace da su ba.

Dayawa sunce wannan kayan gida ne, amma kuma cikin inganci ba shi da kaskantar da na wani waje. Amma a wasu yanayi, yana tsokani ɓacin jini.

Yadda ake amfani: sashi da hanya na jiyya

Matsayi da hanyar gudanar da maganin an ƙayyade su daban-daban a kowane yanayi akan abubuwan glucose a cikin jini kafin abinci da 1-2 sa'o'i bayan cin abinci, sannan kuma ya danganta da matsayin glucosuria da halayen cutar.

Ana gudanar da maganin s / c, cikin / m, in / in, mintuna 15-30 kafin cin abinci. Hanyar gudanarwa mafi yawancin lokuta shine sc. Tare da ketoacidosis mai ciwon sukari, coma mai ciwon sukari, a lokacin aikin tiyata - in / in da / m.

Tare da monotherapy, yawan sarrafawa yawanci sau 3 a rana (idan ya cancanta, har zuwa 5-6 sau a rana), ana canza wurin allura kowane lokaci don guje wa ci gaban lipodystrophy (atrophy ko hauhawar mai mai subcutaneous).

Matsakaicin adadin yau da kullun shine 30-40 LATSA, a cikin yara - 8 IEaukaka, to, a cikin matsakaicin kashi na yau da kullun - 0.5-1 PIECES / kg ko 30-40 LIKE sau 1-3 a rana, idan ya cancanta - 5-6 sau a rana. A cikin adadin yau da kullun wanda ya wuce 0.6 U / kg, dole ne a gudanar da insulin a cikin nau'in 2 ko fiye da allura a cikin sassan daban-daban na jiki.

Yana yiwuwa a haɗu tare da insulins masu aiki na dogon lokaci.

Ana tattara maganin insulin daga murfin ta hanyar huɗa tare da allura mai kaɗa ta roba mai zartar da murhu bayan an cire maɓallin alumuran tare da ethanol.

Aikin magunguna

Tsarin insulin gajere. Yin hulɗa tare da takamaiman mai karɓa akan membrane na sel, yana samar da hadaddun mai karɓar insulin. Ta hanyar haɓaka aikin cAMP (a cikin ƙwayoyin mai da ƙwayoyin hanta) ko kai tsaye shiga cikin sel (tsokoki), ƙwaƙwalwar mai ɗaukar insulin ɗin tana ƙarfafa ayyukan cikin ciki, gami da kira na enzymes masu yawa (hexokinase, pyruvate kinase, glycogen synthase, da sauransu). Rage yawan haɗuwa da glucose a cikin jini shine saboda karuwa a cikin jijiyoyin zuciya, karɓar ɗaukar kaya da kuma ƙaddara kyallen takarda, haɓakar lipogenesis, glycogenogenesis, ƙwayar furotin, raguwar ƙirar glucose ta hanta (raguwa a fashewar glycogen), da dai sauransu.

Bayan allurar sc, tasirin yana faruwa ne a tsakanin mintina 20 zuwa 30, ya kai matsakaici bayan sa'o'i 1-3 sannan ya ci gaba, gwargwadon kashi, 5-8 awanni. Yawancin maganin ya dogara da kashi, hanyar, wurin gudanarwa kuma yana da mahimman halayen mutum .

Side effects

Allergic halayen (urticaria, angioedema - zazzabi, ƙarancin numfashi, saukar karfin jini),

hypoglycemia (pallor na fata, ƙara yawan shaye shaye, gumi, palpitations, rawar jiki, yunwar, damuwa, damuwa, paresthesias a bakin, ciwon kai, nutsuwa, rashin bacci, tsoro, yanayi na bacin rai, tashin hankali, hali mai ban mamaki, rashin motsi, magana da rikicewar magana da hangen nesa), hauhawar jini,

hauhawar jini da kuma ciwon sukari acidosis (a ƙarancin allurai, injections, abinci mara kyau, daga yanayin zazzabi da cututtukan fata): amai, ƙishirwa, rage cin abinci, fitsarin fuska),

mai rauni mara nauyi (har zuwa cigaban premaose da coma),

raunin gani na hankali (yawanci a farkon farawa),

immunological giciye-halayen da insulin na mutum, karuwa a titin na anti-insulin kwayoyin, tare da karuwa a cikin glycemia,

hyperemia, itching da lipodystrophy (atrophy ko hauhawar mai mai subcutaneous) a wurin allurar.

A farkon jiyya - busa da rauni na nakasa (suna ɗan lokaci kuma sun ɓace tare da ci gaba da jiyya).

Haɗa kai

Magunguna ba tare da maganin wasu magunguna ba.

Tasirin hypoglycemic yana haɓaka ta hanyar sulfonamides (gami da magunguna na hypoglycemic na baka, sulfonamides), MAO inhibitors (ciki har da furazolidone, procarbazine, selegiline), inhibitors na carbonic anhydrase inhibitors, ACE inhibitors, ACE inhibitors, NSAIDs (gami da salicylates), anabolic (ciki har da stanozolol, oxandrolone, methanedienone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, phenfluramine, Li + shirye-shirye, pyridoxine, quinidine, quinine, etloin, chloroquin

Hypoglycemic effects na sosai glucagon, girma hormone, corticosteroids, na baka hana, estrogens, thiazide da kuma "madauki" diuretics, BCCI, thyroid hormones, heparin, sulfinpyrazone, sympathomimetics, danazol, tricyclics, clonidine, BCCI, diazoxide, morphine, marijuana, nicotine, phenytoin , epinephrine, H1-histamine mai hana masu tallatawa.

Beta-blockers, reserpine, octreotide, pentamidine zasu iya haɓakawa da raunana tasirin hypoglycemic na insulin.

Rinsulin P - umarnin don amfani

Rinsulin P ana ɗaukar insulin ɗan adam. An samo shi saboda amfani da fasahar DNA. Insulin mai matsala mara launi ne, bayyananne. Magungunan an yi niyya don allura cikin ciki, da intramuscularly da subcutaneously. Ma'aunin hypoglycemic an yi niyya ne ga waɗanda matakan su na sukari na jini ya ragu zuwa matakin mai mahimmanci.

Abun ciki da nau'i na saki

Magani don allura

Insulin ɗan adam

Masu halarta suna cikin shirye-shiryen: glycerol (glycerin) - 16 MG, metacresol - 3 MG, ruwa d / i - har zuwa 1 ml. Ofarar kwalban ita ce 10 ml. An sanya shi a cikin kwali mai kwali, marufi firinji yana da harsashi 5. Gilashin gilashin da aka saka a cikin takaddun sirinji na Multi-kashi, wanda aka tsara don maimaita allura, yana riƙe da 3 ml.

Magunguna da magunguna

Tsawon lokacin da miyagun ƙwayoyi ke ƙaddara shi da ƙimar ɗarin insulin a cikin jini kuma ya dogara da dalilai huɗu:

• daga kashi na miyagun ƙwayoyi (yawan insulin allura),
• daga maida hankali ga insulin a cikin magani,
• wuraren allura (cinya, gindi, ciki),
• Hanyar gudanarwa (intramuscularly, intravenously, subcutaneously).

A matsakaici, bayan gudanarwa, insulin ya fara aiki a cikin minti 20-30, ana samun sakamako mafi girma tsakanin sa'o'i 1-3. Sakamakon magani, dangane da kashi, yana ɗauki tsawon awa 8. Rashin kyawun maganin shine cewa an rarraba mafita ba tare da haɗuwa ba tsakanin ƙashin tsoka. Kwayoyin insulin sun lalace ta hanyar insulinase a cikin hanta da ƙodan. An cire Rinsulin, a matsayin mai mulkin, da kodan.

Sashi da gudanarwa

Matsayi da hanyar gudanar da magani ya kamata likita ya ƙaddara.

Gudun ƙarƙashin ƙasa shine hanya mafi gama gari. Cikin zuciya da jijiyoyin zuciya, ana gudanar da maganin a lokuta mafi ƙima, alal misali, tare da tiyata mai zuwa ko cutar gudawa.

Ana gudanar da insulin a cikin mintuna 20-30 kafin cin abincin wanda ya ƙunshi carbohydrates. Iya warware matsalar ya kamata ya zama a dakin zafin jiki.

An allurar da maganin a cikin bangon ciki na ciki, inda an sami mafi yawan sha. Kuna iya tsayawa cikin cinya, gindi, ko yanki mai juyayi na kafada. Lokacin gudanar da aikin insulin a ƙarƙashin, yana da mahimmanci kada ku cutar da jijiyoyin jini. Ba za ku iya saka farashi ba a wuri guda sau da yawa a jere, akwai hadarin lipodystrophy.

Game da monotherapy, ya kamata a gabatar da miyagun ƙwayoyi a cikin jiki sau 3 a rana (ga wasu marasa lafiya - sau 5-6). Dangane da tattarawar glucose a cikin jini, kashi na yau da kullum na miyagun ƙwayoyi yana daga 0.3 zuwa 1 IU / kg na nauyin jiki.

Amfani da katako ba zai zama karbuwa ba idan mafita ya daskare ko hazo ya bayyana a ciki. Za'a iya amfani da akwati da allura sau ɗaya.

Yin amfani da alkairin sirinji dole ne ya faru gwargwadon umarnin mai sana'anta. Kafin aiwatar da hanyar, kuna buƙatar cire alkalami guda ɗaya daga firiji kuma jira har sai maganin insulin ya isa zafin jiki a ɗakin, sannan amfani da allura zaka iya shigar da miyagun ƙwayoyi. Bayan allura, ya kamata a kwance allurar tare da hula kuma a cire shi nan da nan don aminci.

Anainss Rinsulin P

Akwai isasshen adadin analogues na miyagun ƙwayoyi, duka na Rasha da na kasashen waje.

• Actrapid NM (Novo Nordisk, Denmark),
• Biosulin (Pharmstandard-UfaVITA, Russia),
• Gensulin R ("Bioton S. A., Poland),
• Vosulim-R (Wokhard Ltd, India),
• Insuran R (Cibiyar Binciken Kwayoyin Kimiya ta RAS, Russia),
• Rosinsulin R (Synthesis Honey, Russia),
• Monoinsulin CR (Belmedpreparaty, Belarus),
• Hum Rar R 100 Rivers (Indar, Ukraine),
• Regular Humulin (Lilly Faransa, Faransa).

Rinsulin R magani ne wanda GEROPHARM-Bio ya kera. .Da kayan kwalliya na maganin gargajiya a magunguna a Moscow:

Aiki mai aiki na kungiyoyi P da C

Anyi la'akari da Rosinsulin P insulin gajere mai aiki mai narkewa. Yana iya hulɗa da sauƙi tare da mai karɓa na musamman akan ƙwayoyin waje na sel, suna samar da hadaddun mai ɗaukar insulin. Gabanin tushen aikin jiyya, ƙwaƙwalwar CAMP a cikin hanta da ƙwayoyin mai ke ƙaruwa. Abubuwan da ke tattare da magunguna suna kuma shiga cikin ƙwayoyin tsoka, suna motsa ayyukan hexokinase da sauran hanyoyin cikin ciki.

Saboda karuwar kwayar sunadarai, yawan glucose a cikin jini da rushewar glycogen zai ragu. Bayan allura, ana lura da bayyanar minti 30. Tsawon lokacin aiwatarwa daga kashi ɗaya ya kai awowi 8. Darajar wannan alamar ta dogara da sashi, hanyar da wurin gudanarwa.

Rosinsulin C an gabatar dashi azaman insulin-isophan tare da matsakaita mai kyau. Magungunan yana rage haɗuwa da glucose a cikin jini, yana ƙara shanshi ta hanyar kyallen, yana inganta lipogenesis. Wannan yana rage yawan samarda glucose ta hanta.

Bayan allura, abun da ke ciki ya fara aiki bayan awanni 2. Ana samun ingantaccen aiki bayan awa 12. Tasirin warkewa har zuwa kwana guda. Darajar wannan mai nuna alamar kai tsaye ta shafi kashi da abun da ke cikin magani.

Manuniya da contraindications

Alamu don alƙawarin wannan magani suna da yawa.

Wadannan sun hada da:

• nau'in 1 da nau'in 2 mellitus na ciwon sukari (in babu sakamakon sakamako daga magani tare da wakilai na hypoglycemic na baka ko tare da isasshen tasiri),
• ciwon sukari da ya faru a lokacin lokacin gestation,
• ketoacidosis
• ketoacidotic coma,
• ya dauki dogon lokacin insulin magani,
• cututtuka a cikin masu ciwon sukari.

Waɗannan sifofin suna buƙatar magani tare da jami'ai masu dauke da insulin, amma kasancewar su ba ya nufin cewa ya kamata a fara wannan magani nan da nan. Da farko dai, ka tabbata babu abubuwan da ke faruwa. Saboda su, yawanci dole ne ku watsar da amfani da Rosinsulin.

Babban contraindications sune:

Gano waɗannan fasalolin yana buƙatar zaɓar wasu hanyoyi, tunda amfani da Rosinsulin zai iya haifar da lalata.

Umarnin don amfani

Don samun sakamako, kowane magani yakamata a yi amfani da umarnin. Rashin hankali ga Rosinsulin baya taimakawa sosai, tunda kowane mai haƙuri na iya samun fasali waɗanda ke buƙatar gyaran jadawalin da allurai. Sabili da haka, ana buƙatar umarnin bayyananne daga likita.

Ana amfani da wannan magani azaman allura, wanda aka ba da ƙarƙashin. Wani lokacin an yarda da gudanarwar abu na ciki ko na ciki, amma kwararre ne kawai yake aiwatar da shi.

Ana lissafta yawan injections da yawan magungunan daban-daban dangane da halayen hoton asibiti.Idan babu ƙarin fasali, ana amfani da 0.5-1 IU / kg na nauyi kowace rana. Nan gaba, ana yin nazarin canje-canje a cikin glucose jini kuma ana daidaita sashi idan ya cancanta.

Wani lokaci ana amfani da Rosinsulin a hade tare da shirye-shiryen insulin na dogon lokaci. A wannan yanayin, dole ne a canza kashi na maganin.

Ya kamata a ba da allurai kafin abinci (na minti 20-30). A gida, ana gudanar da maganin a karkashin gwiwa a cinya, kafada, ko bangon ciki na ciki. Idan kashi da likita ya tsara ya wuce 0.6 IU / kg, ya kamata a raba shi zuwa sassa da yawa. Ya kamata a sauya wuraren da allurar ta kasance don babu matsalolin fata.

Umarni na bidiyo don gabatarwar insulin tare da alkalami mai sike:

Marasa lafiya na musamman da kuma Jagorori

Wasu marasa lafiya suna buƙatar kulawa ta musamman. Wannan ya faru ne saboda halayen jikinsu, wanda Rosinsulin zai iya shafan su ta wata hanyar da ba ta dace ba.

Wadannan marasa lafiya sun hada da:

1. Yara. Ba a hana haihuwa ba, ba a hana maganin insulin ba, amma yana buƙatar ƙarin kulawa ta likitoci. An wajabta adadin magunguna a kansu kaɗan da masu cutar sikari.
2. Ciki Wannan magani ba ya cutar da mata yayin haihuwa, saboda haka ana amfani dashi sau da yawa don magance alamun cutar ciwon suga. Amma yayin daukar ciki, buƙatar insulin na iya bambanta dangane da tsawon lokaci, don haka kuna buƙatar saka idanu kan karatun glucose da daidaita ɓangaren magunguna.
3. Iyayen mata masu shayarwa. Hakanan ba'a haramta su daga ilimin insulin ba. Abubuwan da ke aiki na miyagun ƙwayoyi na iya wucewa cikin madara, amma ba su da mummunan tasiri ga jaririn. Insulin shine kwayar furotin wanda jikin jariri yake sauƙaƙa shi. Amma yayin amfani da Rosinsulin, matan da suke yin aikin ciyarwa na ɗabi'a suna buƙatar bin abincin.
4. Tsofaffi mutane. Dangane da bukatarsu ta taka tsantsan yana faruwa ne saboda canje-canje da suka shafi shekaru. Wadannan canje-canjen na iya shafar gabobin da yawa, gami da hanta da kodan. A gaban take hakki a cikin aikin wadannan gabobin, karancin insulin ya sauka a hankali. Sabili da haka, an tsara marasa lafiya masu shekaru 65 da ƙananan magani na ƙananan ƙwayoyi.

Hakanan kuna buƙatar kulawa da hankali game da kulawa da mutane tare da cututtukan cututtuka daban-daban. Wasu daga cikinsu suna shafar aikin Rosinsulin.

Daga cikinsu ana kiransu:

1. Bala'i a cikin aikin kodan. Saboda su, motsin abubuwa masu aiki suna raguwa, wanda zai iya haifar da tarawarsu da kuma faruwawar ƙin jini. Saboda haka, irin waɗannan mutane suna buƙatar yin lissafin a hankali a hankali.
2. Pathology na hanta. A ƙarƙashin tasirin insulin, hanta tana rage jinkirin samar da glucose. Idan akwai matsaloli a cikin aiki, ana iya samarda glucose sosai a hankali, wanda ke haifar da karancinsa. Wannan yana nufin cewa idan akwai wani lahani a cikin ayyukan wannan jikin, to yakamata a rage kashi na maganin.

Magungunan Rosinsulin kadai ba ya haifar da karkacewa a cikin ikon mayar da hankali kuma baya rage jinkirin. Zasu iya tsokanar su da yanayin rashin lafiyar da ke haifar da rashin amfani da wannan wakili. A wannan batun, tuki da ayyuka masu haɗari lokacin amfani da wannan magani ba a so.

Farfesa

Ana maganin miyagun ƙwayoyi na rukunin C sau 1-2 a rana. Maƙerin ya ba da shawara kowane lokaci na gaba don canza wurin allurar. Ana shan miyagun ƙwayoyi minti 30 kafin karin kumallo. Da wuya, an sanya allurar rigakafi tare da Rosinsulin C ga marassa lafiya An haramtawa gudanarwar cikin jijiyoyin jini.

Sashi aka zaɓi akayi daban-daban. Ya dogara da abubuwan glucose a cikin fitsari da jini, halayen hanyar cutar. A cikin daidaitattun yanayi, ya isa ka shigar da 8-24 IU sau ɗaya a rana. Idan mai haƙuri yana da ƙwaƙwalwar ƙwayar insulin sosai, an tsara maganin a cikin ƙaramin ƙima, kuma tare da rage ji na ƙwarai - a cikin kashi sama da 24 IU kowace rana. Idan da rana sashi ya wuce 0.6, ana yin allura biyu a wurare daban-daban. Marasa lafiya waɗanda suka karɓi fiye da 100 IU kowace rana suna asibiti tare da maye gurbin insulin.

Jiyya tare da Rosinsulin P shine mutum ɗaya. Sashi da hanyar shigarwar ya dogara da kirdadon jini kafin da kuma bayan abinci, matakin glycosuria. Hanyar Gudanarwa:

Mafi sau da yawa ana gudanar da Rosinsulin P a ƙarƙashin ƙasa. Idan an tabbatar da coma mai ciwon sukari ko kuma an nuna masa tiyata, to ana gudanar da abun cikin ciki ne ko akasin haka. Tare da monotherapy, ana amfani da maganin sau uku a rana. A lokuta da saukin yanayi, yawan tafiyarwa ya kai sau 6 a rana. Don hana atrophy, lipodystrophy, shafin allurar yana canza kowane lokaci mai zuwa.

Yawan yau da kullun akan matsakaita kada ya wuce raka'a 40. An tsara yara a cikin kashi 8 raka'a. Idan an tsara fiye da raka'a 0.6 a 1 kg na nauyi, ana gudanar da insulin sau biyu kuma a sassa daban-daban na jiki. Idan ya cancanta, ana hade Rosinsulin C tare da insulin aiki na tsawon lokaci.

M halayen

Magungunan kowane ƙungiyar da ake tambaya na iya haifar da rashin lafiyar jiki a cikin nau'in cutar urticaria. Dyspnea yana bayyana sau da yawa, matsin lamba yana raguwa. Sauran bayyanar cututtuka mara kyau na Rosinsulin P da C:

• rashin bacci
• migraine
• talaucin abinci
• matsalolin sani
• titara titer na rigakafin insulin.

A matakin farko na jiyya, marasa lafiya sukan yi gunaguni na rashin lafiyar edema da nakasasshe. Kwayar cutar ta ɓace da wuri-wuri. An ba da kulawa ta musamman ga yanayin kwalbar. Kafin gudanar da mulki, ana bincika mafita don nuna gaskiya. Idan akwai gawarwakin kasashen waje a cikin ruwan, ba a amfani da Rosinsulin.

An daidaita yawan magunguna don kamuwa da cuta, dysfunction thyroid, ciwo na Addison. Hypoglycemia sau da yawa yana tasowa a matsayin alama ta yawan abin sha. An bayyana wata alama mai kama da wannan yayin maye gurbin Rosinsulin C da P tare da wani wakili. Sauran alamun cutar yawan maye

• amai
• zawo
• raguwa a cikin aiki aiki.

Idan asibitin da ke sama ya bayyana, ana ba da shawarar sanar da likitan da ke halartar. Sau da yawa ana shawarci mara lafiya ya tafi asibiti. An zaɓi makirci mai zuwa bayan cikakken binciken haƙuri.

Idan mai haƙuri yana da cutar hanta da koda, to an rage buƙatar maganin. Matsayi na glucose na iya canzawa lokacin da aka canza haƙuri daga dabba zuwa insulin ɗan adam. Dole ne a tabbatar da irin wannan canzawar ta hanyar likita Ana yin hakan ne a karkashin kulawar likitoci.

Shawarar likita

Masu ciwon sukari sun dakatar da jin zafin jiki na yawan zafin jiki ta hanyar shan sukari. Lokacin da yanayin ya tsananta, ana daidaita jiyya. Idan mara lafiyar tana da juna biyu. ana yin la'akari da abubuwa masu zuwa:

• A cikin watanni uku, an rage yawan kashi.
• A cikin watanni na 2 da na 3, buƙatar Rosinsulin yana ƙaruwa.

Yayin haihuwa da kuma bayan haihuwa, buƙatar rage magungunan ta ragu sosai. Tare da lactation, mace tana karkashin kulawar likitocin yau da kullun.

Daga yanayin ra'ayi, Rosinsulin P da C basu dace da hanyoyin magance wasu magunguna ba. An inganta tasirin hypoglycemic ta hanyar ciwan sulfonamides, monoamine oxidase inhibitors da enzyme angiotensin. Tasirin warkewa yana raunana ta glucagon, glucocorticoids, maganin hana haihuwa, Danazole. Masu hana Beta-blockers suna haɓakawa da raunana tasirin Rosinsulin.