Menene bambanci tsakanin atorvastatin da rosuvastatin?

Babban cholesterol shine sanadiyyar cututtuka da dama na zuciya, kwakwalwa, tasoshin yanki. Atherosclerosis (adana sinadarin cholesterol a jikin bango) shine ke haifar da asarar rayuka a duniya da kuma kasashen tsohuwar tarayyar Soviet. Statins sune magungunan da zasu iya hana, kuma tare da tsawan amfani da su, dakatar da haɓakar atherosclerosis. Yin kwatancen Atorvastatin da Rosuvastatin, a matsayin wakilai mafi kyau na biyu na wannan rukunin, zai ba ku damar zaɓar magani ga kowane ɗaya daban.

Atorvastatin da rosuvastatin suna dauke da kayan aiki iri ɗaya.

Hanyar aikin

Dukansu magunguna wakilan rukuni ɗaya ne na masana'antar magunguna, sabili da haka tsarin aikinsu yayi kama da haka. Bambanci tsakanin su suna cikin ƙarfin aiwatarwa: don cimma tasirin sakamako na asibiti, kashi ɗaya na Rosuvastatin na iya zama rabin Atorvastatin.

Hanyar aiwatar da kwayoyi shine don kawar da enzyme da ke tattare da haɓakar ƙwaƙwalwar cholesterol. Sakamakon haka, an rage yawan adadin ƙwayoyin cuta da ƙananan ƙarfi da ƙarancin lipoproteins (LDL, VLDL), triglycerides. Su ne sanadin samuwar filaye a hanyoyin jini, bugun zuciya, bugun jini, da dai sauransu.

Dole ne a yi amfani da magungunan biyu a cikin waɗannan lambobin:

• Cike total cholesterol jini,
• Babban matakan LDL, VLDL, triglycerides,
• Cututtukan zuciya na zuciya (isasshen jini ga tsoka zuciya) da dukkan bayyanannunsa (bugun zuciya, angina pectoris),
• Atherosclerosis na aorta, tasoshin da ke kasan mahaifa, kwakwalwa, jijiyoyin koda,
• Tare da cutar hawan jini - don hana haɓakar atherosclerosis.

Contraindications

Ba za a iya amfani da Atorvastatin don:

• Rashin yarda da miyagun ƙwayoyi,
• Cutar cutar hanta,
• Liverarancin aikin hanta,
• Haihuwa da lactation.

• Rashin yarda da miyagun ƙwayoyi,
• Cutar cutar hanta,
• Liverarancin aikin hanta,
• Cutar rashin lafiyar koda
• Tsarin kasusuwa tsoka,
• Shan cyclosporine,
• Haihuwa da lactation
• Age zuwa shekaru 18.

Side effects

Atorvastatin na iya haifar da:

• Ciwon kai
• Rashin ƙarfi
• Rashin damuwa
• Ciwo kirji
• Liverarancin aikin hanta,
• Kumburi da gabobin ENT,
• Abin narkewa cikin damuwa,
• Muscle da ciwon haɗin gwiwa
• Kurajewa
• Allergic halayen.

Sakamakon sakamako na rosuvastatin:

• A ci gaba da ciwon sukari mellitus (mai rauni carbohydrate metabolism),
• Jin zafi a kai
• Abin narkewa cikin damuwa,
• Liverarancin aikin hanta,
• Ciwon ciki
• Rashin ƙarfi.

Sakin siffofin da farashi

Farashin allunan Atorvastatin sun bambanta sosai kan masana'anta:

• 10 MG, 30 inji mai kwakwalwa. - 130 - 260 p,
• 10 mg, 60 inji mai kwakwalwa. - 300 r
• 10 mg, 90 inji mai kwakwalwa. - 550 - 710 r,
• 20 MG, 30 inji mai kwakwalwa. - 165 - 420 r,
• 20 MG, 90 inji mai kwakwalwa. - 780 - 1030 r,
• 40 MG, 30 inji mai kwakwalwa. - 295 - 630 p.

Har ila yau farashin rosuvastatin Allunan yana bambanta sosai:

• 5 MG, 28 inji mai kwakwalwa. - 1970 p
• 5 MG, 30 inji mai kwakwalwa. - 190 - 530 r,
• 5 MG, 90 inji mai kwakwalwa. - 775 - 1020 r,
• 5 MG, 98 inji mai kwakwalwa. - 5620 r,
• 10 mg, 28 inji mai kwakwalwa. - 420 - 1550 r,
• 10 MG, 30 inji mai kwakwalwa. - 310 - 650 p,
• 10 mg, 60 inji mai kwakwalwa. - 620 r
• 10 mg, 90 inji mai kwakwalwa. - 790 - 1480 r,
• 10 mg, 98 inji mai kwakwalwa. - 4400 r,
• 10 mg, 126 inji. - 5360 r,
• 15 MG, 30 inji mai kwakwalwa. - 600 r
• 15 MG, 90 inji mai kwakwalwa. - 1320 r,
• 20 MG, 28 inji mai kwakwalwa. - 505 - 4050 r,
• 20 MG, 30 inji mai kwakwalwa. - 400 - 920 p,
• 20 MG, 60 inji mai kwakwalwa. - 270 - 740 r,
• 20 MG, 90 inji. - 910 - 2170 r,
• 40 mg, 28 inji mai kwakwalwa. - 5880 r,
• 40 MG, 30 inji mai kwakwalwa. - 745 - 1670 r,
• 40 mg, 90 inji mai kwakwalwa. - 2410 - 2880 p.

Rosuvastatin ko Atorvastatin - Wanne ya fi kyau?

Idan kun zabi wane magani ne mafi kyau daga ra'ayi na asibiti, to tabbas zai zama Rosuvastatin. Tunda za'a iya ɗauka a cikin ƙananan sashi, adadin da yawan tasirin sakamako yana ƙasa da na Atorvastatin. Koyaya, yana da tsada sosai, musamman kamfanin kamfanin Teva ko Astrazenek (Krestor) ya samar da su. Aauki magani kowane wata, wanda zai ɗauki wannan adadin mai ban sha'awa ga wasu marasa lafiya yana da sauƙin kawai. A wannan batun, atorvastatin shine mafi ƙarancin Statin.

Wanne ya fi kyau: atorvastatin ko rosuvastatin? Nasiha

• Ina da babbar cutar cholesterol, mahaifina ya mutu sakamakon bugun zuciya a kusan shekaru 40 da haihuwa. Na dade ina shan Atorvastatin, na kusan cika shekaru 40 kuma ba zan mutu ba tukuna, kuma jiragen ruwa sun riga sun yi kyau sosai, amma akwai haƙuri
• Ba zan iya shan wannan magani ba - nan da nan hanta ta fara rauni, rauni ya bayyana,
• A sosai m magani. Ba a jin tasirin hakan ba, amma duk likitoci suna tilasta shi ya sha. Amma gwaje-gwaje suna da kyau a bayansa.

• Ni dai ban iya cinye wannan adadin duk wata ba, duk da cewa ina son sa. Kuma ba zan iya tsayawa Atorvastatin ba,
• Babban sauyawa don atorvastatin: ƙananan sashi, ingantaccen haƙuri,
• Ban gane dalilin da yasa zan biya irin wannan mahaukaci ba idan zaku iya shan analogues mai rahusa.

Menene statins?

Statins sun hada da babban rukuni na kwayoyi da aka yi amfani da su don rage yawan LDL da VLDL a cikin jini.

A cikin aikin likita na yau da kullun, ba za a iya rarraba statins tare da yin rigakafi da magani na atherosclerosis, hypercholisterinemia (hade ko haɗari), da cututtukan zuciya.

Gabaɗaya, magunguna na wannan rukunin suna da tasirin warkewa iri ɗaya, i.e. ƙananan matakan LDL da VLDL. Koyaya, saboda nau'ikan kayan aiki masu aiki da kayan taimako, akwai wasu bambance-bambance waɗanda dole ne a la'akari da su don guje wa raunin da ba shi da kyau.

Yawancin lokaci ana rarraba Statins zuwa I (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) da kuma tsararraki na IV (Pitavastatin, Rosuvastatin).

Statins na iya zama na asali da na roba. Ga ƙwararre, zaɓin samfuran ƙarami, matsakaici, ko sikeli mai haƙuri ga mai haƙuri muhimmiyar ma'ana.

Rosuvastatin da Atorvastatin galibi ana amfani dasu don rage ƙwayar cholesterol. Kowane ɗayan magungunan yana da fasali:

Rosuvastatin yana nufin statins na ƙarni na huɗu. Wakili mai saurin rage yawan sinadarai yana da cikakken aiki tare da matsakaicin sashi na kayan aiki mai aiki. An ƙirƙira shi a ƙarƙashin alamun kasuwanci daban-daban, alal misali, Krestor, Mertenil, Rosucard, Rosart, da dai sauransu.

Atorvastatin nasa ne na tsoffin statan adam III. Kamar misalinsa, yana da asalin halitta, amma yana da babban adadin kayan aiki.

Akwai irin waɗannan maganganun na maganin kamar Atoris, Liprimar, Toovacard, Vazator, da dai sauransu.

Abubuwan sunadarai na magungunan

Duk magungunan suna cikin nau'in kwamfutar hannu. Ana samar da Rosuvastatin a sigogi dayawa - 5, 10 da 20 na mG guda daya na kayan aiki mai aiki. Atorvastatin an saki shi a cikin sashi na 10,20,40 da 80 MG na kayan aiki mai aiki. Da ke ƙasa akwai tebur kwatanta abubuwa masu taimako na sanannun wakilai biyu na statins.

Babban bambanci tsakanin Rosuvastatin da Atorvastatin sune kayan aikin kimiyyar halayyar su. Amfanin rosuvastatin shi ne cewa yana da sauƙin rushewa cikin jini na jini da sauran ruwaye, i.e. shine hydrophilic. Atorvastatin yana da wani fasalin: yana narkewa a cikin mai, i.e. lipophilic ne.

Dangane da waɗannan fasalulluka, sakamakon Rosuvastatin an karkatar da shi ne gaba ɗaya zuwa ƙwayoyin hanta parenchyma, da Atorvastatin - ga tsarin kwakwalwa.

Pharmacokinetics da pharmacodynamics - bambance-bambance

Tuni a matakin shan allunan, akwai bambance-bambance a cikin shan su. Don haka, yin amfani da rosuvastatin bai dogara da lokacin rana ko abinci ba. Kada a cinye Atorvastatin lokaci guda tare da abinci, kamar yadda wannan mummunan abu yana shafar ɗaukar aiki mai aiki. Ana samun mafi girman abun ciki na Atorvastatin bayan sa'o'i 1-2, da Rosuvastatin - bayan awa 5.

Wani bambanci tsakanin statins shine metabolism din su. A jikin mutum, Atorvastatin an canza shi zuwa wani tsari mara amfani ta amfani da enzymes hanta. Don haka, ayyukan miyagun ƙwayoyi yana da alaƙa kai tsaye da aikin hanta.

Hakanan yana tasiri da kwayoyi waɗanda ake amfani dasu lokaci guda tare da Atorvastatin. Analog ɗin sa, akasin haka, saboda ƙananan sashi, kusan ba ya amsawa da wasu kwayoyi. Kodayake wannan bai kubutar da shi daga gaban halayen halayen ba.

Atorvastatin an keɓe shi musamman da bile.

Ba kamar yawancin statins ba, Rosuvastatin kusan ba metabolized a cikin hanta ba: fiye da 90% na kayan ana cire su ba tare da hanjinsu ba kuma kawai 5-10% ta hanta.

Inganci da Ra'ayin Kasuwanci

Babban aikin magungunan statin shine rage yawan taro na LDL a cikin jini da kuma ƙara matakin HDL.

Saboda haka, zaɓa tsakanin Atorvastatin da Rosuvastatin, dole ne mu kwatanta yadda suke rage ƙwayar cholesterol.

Wani binciken kimiyya da aka yi kwanan nan ya tabbatar da cewa rosuvastatin magani ne mafi inganci.

Sakamakon gwaji na asibiti an gabatar da shi a ƙasa:

1. Tare da daidaita allurai na kwayoyi, Rosuvastatin yana rage cholesterol LDL da 10% fiye da yadda ake amfani da shi. Wannan fa'idar ta ba da damar yin amfani da magani ga marasa lafiya da ke fama da matsanancin rashin ƙarfi.
2. Mitar ci gaban rikicewar cututtukan zuciya da farawa mai muni ya fi girma a Atorvastatin.
3. Halin rashin halayen guda ɗaya ne duka magungunan biyu.

Kwatanta tasirin rage rage tasirin cholesterol "mara kyau" yana tabbatar da gaskiyar cewa Rosuvastatin shine magani mafi inganci. Koyaya, mutum ya kamata ya manta game da irin waɗannan abubuwan kamar kasancewar contraindications, sakamako masu illa da farashi. An gabatar da kwatancen farashin magungunan guda biyu a cikin tebur.

Don haka, atorvastatin analog ne mai rahusa wanda mutane masu karamin karfi zasu iya samarwa.

Wannan shine abin da marasa lafiya suke tunani game da kwayoyi - An yarda da Rosuvastatin da kyau kuma ba tare da matsaloli ba. Lokacin da aka ci shi, ana rage ƙiba

Kwatanta kwayoyi na taimaka wajan yanke hukunci cewa a halin yanzu na ci gaban magani, matsayi na farko a cikin mafi kyawun allunan kwayar cholesterol ana dauke da su ta hanyar siffofin mutanen na hudu, gami da Rosuvastatin.

Game da miyagun ƙwayoyi Rosuvastatin da analogues an bayyana su a cikin bidiyo a wannan labarin.