Mildronate® (500 MG) Meldonium

A cikin wannan labarin, zaku iya karanta umarnin don amfani da miyagun ƙwayoyi Mildronate. Yana ba da ra'ayi daga baƙi zuwa shafin - masu amfani da wannan magani, kazalika da ra'ayoyin kwararrun likitocin game da amfani da Mildronate a cikin aikin su. Babban buƙatar shine a ƙara ra'ayoyinku game da miyagun ƙwayoyi: maganin ya taimaka ko bai taimaka kawar da cutar ba, menene rikice-rikice da sakamako masu illa da aka lura, mai yiwuwa ba sanar da mai masana'anta a cikin bayanin ba. Analogs na Mildronate a gaban kasancewa analogues na tsarin analogues. Yi amfani da shi don magance cututtukan zuciya da bugun jini da haɓaka metabolism a cikin kyallen a cikin manya, yara, har ma lokacin daukar ciki da lactation.

Mildronate - magani ne wanda ke inganta metabolism. Meldonium (abu mai aiki na miyagun ƙwayoyi Mildronate) alama ce ta tsarin gamma-butyrobetaine, wani abu ne wanda aka samo a cikin kowane ƙwayar jikin mutum.

A karkashin yanayin karuwar kaya, Mildronate ya dawo da daidaituwa tsakanin isar da bukatar oxygen na sel, yana kawar da tarin kayan abinci mai guba a cikin sel, yana kare su daga lalacewa, har ila yau yana da tasirin tonic. Sakamakon amfani da shi, jiki yana samun ikon jure nauyin da sauri dawo da kayan ajiyar makamashi. Saboda waɗannan kaddarorin, ana amfani da Mildronate don magance rikice-rikice na tsarin zuciya da jijiyoyin jini, samar da jini ga kwakwalwa, da haɓaka aikin jiki da na kwakwalwa.

Sakamakon raguwa a cikin taro na carnitine, gamma-butyrobetaine tare da kaddarorin vasodilating yana haɓaka mai ƙarfi. A cikin lalacewa mai rauni na ischemic myocardial, Mildronate yana jinkirta samuwar yankin necrotic, yana gajarta lokacin murmurewa.

A cikin raunin zuciya, miyagun ƙwayoyi suna kara yawan ƙwayar cuta na zuciya, yana ƙaruwa da haƙuri, kuma yana rage yawan tashin hankalin angina.

A cikin mummunar cuta da rashin lafiyar ischemic na wurare dabam dabam na haɓakar cerebral yana inganta wurare dabam dabam na jini a cikin ischemia, yana ba da gudummawa ga sake rarraba jini a madadin yankin ischemic.

Inganci ga cututtukan jijiyoyin bugun gini da na dystrophic na fundus.

Magungunan yana kawar da rikice-rikice na aiki na tsarin juyayi, haɓakawa daga tushen ci gaba da shan giya a cikin marasa lafiya tare da mashahuri na shan giya tare da ciwo na cirewa.

Pharmacokinetics

Bayan gudanar da baki, ana magance ƙwayar cutar cikin hanzari daga narkewa. Yana cikin metabolized a jiki tare da samuwar manyan abubuwan metabolites guda biyu wadanda kodan ke cirewa.

Alamu

• A cikin hadadden farji na cututtukan zuciya da jijiyoyin jini (angina pectoris, infarction na zuciya), gazawar zuciya, rashin aikin zuciya,
• A cikin hadaddun farfajiya na cututtukan cututtukan cututtukan zuciya da na rashin ƙwaƙwalwar ƙwayar cuta (tsoka da ƙarancin ƙwayar jijiyoyin jiki),
• rage aiki
• damuwa na jiki (gami da tsakanin athletesan wasa),
• karban ciwo a cikin mashahuran shan giya (a hade tare da takamaiman magani don shan giya),
• hemophthalmus, retinal basur na etiologies,
• thrombosis na tsakiyar jijiya na retina da rassanta,
• retinopathies na daban-daban etiologies (masu ciwon sukari, hauhawar jini).

Sakin Fom

Capsules 250 MG da 500 MG (wasu lokuta ana kiran allunan da ba daidai ba, amma nau'in kwamfutar hannu na Mildronate baya zama)

Magani don maganin cikin ciki, allurar ciki da allurar parabulbar (injections in ampoules).

Umarnin don amfani da sashi

Dangane da yiwuwar haɓaka sakamako mai ban sha'awa, ana bada shawarar yin amfani da miyagun ƙwayoyi da safe.

Don cututtukan zuciya kamar yadda wani ɓangare na ƙwaƙwalwar ƙwayar cuta, an tsara magunguna a baki a cikin kashi 0,5-1 g kowace rana, yawan amfani shine 1-2. Ainihin magani shine makonni 4-6.

Tare da ƙwaƙwalwar ƙwayar cuta ta asali na dishormonal myocardial dystrophy mai ƙyama, an tsara Mildronate ta hanyar magana da ƙwayoyin cuta sau 250 a sau 2 a rana. Hanyar magani shine kwana 12.

Game da hatsarin cerebrovascular a cikin mummunan lokaci, ana gudanar da miyagun ƙwayoyi a cikin jijiya (a cikin tsari mai dacewa - 500 MG sau ɗaya a rana don kwanaki 10), to, sun canza zuwa shan miyagun ƙwayoyi a cikin 0,5-1 g kowace rana. Babban aikin jiyya shine makonni 4-6.

A cikin rikicewar cuta na ƙwayar cuta na ƙwayar cuta, ana ɗaukar maganin a baki a 0.5-1 g kowace rana. Babban aikin jiyya shine makonni 4-6. An sake maimaita darussan daban daban daban sau 2-3 a shekara.

Don ƙoƙari na kwakwalwa da ta jiki, an wajabta shi a cikin 250 mg 4 sau a rana. Aikin magani shine kwanaki 10-14. Idan ya cancanta, ana maimaita maganin bayan makonni 2-3.

Ana ba da shawarar 'yan wasa su yi amfani da 0.5-1 g sau 2 a rana kafin horo. Tsawon lokacin karatun a cikin kwanakin shiri shi ne 14-21, a lokacin gasar - kwanaki 10-14.

A cikin shan giya na yau da kullun, ana wajabta maganin a baki sau 500 a sau 4 a rana. Aikin jiyya shine kwanaki 7-10.

Don cututtukan zuciya kamar yadda wani ɓangare na ƙwayar cuta mai rikitarwa, an wajabta magungunan a kashi na 0.5-1 g kowace rana a cikin ciki (5-10 ml na maganin allura tare da taro na 500 mg / 5 ml), yawan amfani shine sau 1-2 a rana. Hanyar magani shine makonni 4-6.

Idan akwai haɗari na cerebrovascular a cikin mummunar aiki, ana gudanar da magani na iv 500 MG sau ɗaya a rana don kwanaki 10, to, sun canza zuwa shan miyagun ƙwayoyi a ciki (a cikin sashi na dacewa, 0.5-1 g kowace rana). Babban aikin jiyya shine makonni 4-6.

Game da cututtukan jijiyoyin jiki da cututtukan cututtukan fata na dystrophic, ana gudanar da Mildronate parabulbarly a cikin maganin 0.5 ml don allura tare da taro na 500 mg / 5 ml na kwanaki 10.

Don damuwa da damuwa ta jiki da ta jiki, ana wajabta iv 500 MG sau ɗaya a rana. Aikin magani shine kwanaki 10-14. Idan ya cancanta, ana maimaita maganin bayan makonni 2-3.

A cikin shan giya na yau da kullun, ana wajabta magungunan iv 500 MG 2 sau a rana. Aikin jiyya shine kwanaki 7-10.

Side sakamako

• samarin
• canje-canje a cikin karfin jini
• Tashin hankalin mutum,
• ciwon kai
• bayyanar cututtuka na dyspeptic
• halayen rashin lafiyan (jan fata, fatar jiki ko kumburi, amalar fata, kumburi),
• janar gaba daya
• kumburi.

Contraindications

• pressureara yawan matsa lamba ciki (ciki har da lamuran gurɓataccen ruwan ciki, ciwan ciki),
• yara da matasa 'yan ƙasa da shekara 18,
• rashin hankali ga miyagun ƙwayoyi.

Haihuwa da lactation

Ba a tabbatar da amincin amfani da Mildronate yayin daukar ciki ba. Don guje wa mummunar illa ga tayin, bai kamata a sanya maganin a lokacin daukar ciki ba.

Ba a sani ba ko an watsa maganin a cikin nono. Idan ya zama dole ayi amfani da Mildronate yayin shayarwa, ya kamata a daina shayar da jarirai nono.

Umarni na musamman

Marasa lafiya da cututtukan hanta da cututtukan koda yakamata suyi hankali tare da tsawan amfani da magani. Idan kuna buƙatar amfani da magani na dogon lokaci (fiye da wata daya), ya kamata ku nemi shawarar kwararrun likita.

Shekaru da yawa na gwaninta a cikin kula da matsanancin myocardial infarction da kuma angina mai rauni a cikin sassan zuciya sun nuna cewa Mildronate ba magani ne na farko ba don cutar sankarar mahaifa.

Amfani da yara

A cikin yara da matasa a ƙarƙashin shekara 18, ingantaccen da amincin Mildronate a cikin nau'in capsules da allura ba a kafa shi ba.

Tasiri kan ikon tuka motoci da hanyoyin sarrafa abubuwa

Babu wata shaida game da mummunan sakamako na Mildronate akan ƙimar motsin psychomotor.

Hulɗa da ƙwayoyi

Lokacin da aka haɗu, Mildronate yana haɓaka aikin aikin magungunan antianginal, wasu magungunan antihypertensive, cardiac glycosides.

Ana iya haɗuwa da Mildronate tare da magungunan antianginal, maganin anticoagulants da jami'ai na antiplatelet, magungunan antiarrhythmic, diuretics, bronchodilators.

Lokacin da aka haɗe tare da Mildronate nitroglycerin, nifedipine, alpha-blockers, magungunan antihypertensive da na gefe na jijiyoyi, tachycardia matsakaici, hypotension na iya haɓaka (yakamata a yi taka tsantsan lokacin amfani da wannan haɗin).

Analogs na miyagun ƙwayoyi Mildronate

Tsarin analogues na mai aiki abu:

• 3- (2,2,2-Trimethylhydrazinium) daskararre,
• Vasomag,
• Idrinol
• Cardionate
• Medatern
• Meldonium,
• Meldonius Eskom
• Meldonium na bushewa,
• Jin kai,
• Midolat
• Trimethylhydrazinium yana narkewar ruwa mai narkewa.

Form sashi

Capaya daga cikin capsule ya ƙunshi

abu mai aiki - meldonium dihydrate 500 MG,

magabata: sitaci dankalin turawa, sitataccen silicon dioxide, alli,

kwalin fata (jiki da hula): titanium dioxide (E 171), gelatin.

Hard gelatin capsules No. 00 fari. Abun ciki farin lu'ulu'u ne mai sanyin kamshi. Foda yana hygroscopic.

Kayan magunguna

Pharmacokinetics

Bayan gudanar da magana guda ɗaya na meldonium, matsakaicin yawan plasma maida hankali (Cmax) da yanki a ƙarƙashin tsarin lokaci-lokaci (AUC) yana ƙaruwa gwargwadon yawan aikin da aka yi amfani da shi. Lokacin da za a isa a kai yawan plasma maida hankali (tmax) shine 1-2 awanni. Tare da sake maimaitawa, ana samun daidaiton ƙwayar cuta tsakanin plasma cikin awa 72 zuwa 72 bayan aikace-aikacen kashi na farko. Rarrawar ƙwayar meldonium a cikin jini yana yiwuwa. Abinci yana rage jinkirin shan meldonium ba tare da canza Cmax da AUC ba.

Meldonium daga magudanar jini yana yadawa da sauri zuwa kyallen takarda. Tabbatar da furotin na Plasma yana ƙaruwa tare da lokaci bayan gudanarwar kashi. Meldonium da metabolites sa a gefe sun shawo kan matsalar hana hawan jini. Ba a gudanar da nazarin tsararren ƙwayar meldonium a cikin nono na ɗan adam ba.

Meldonium ne yafi metabolized a cikin hanta.

Harshen tashin hankali yana taka rawa sosai a cikin hirar meldonium da metabolites dinsa. Kashe rabin rayuwar meldonium (t1 / 2) kamar awanni 4 ne. Tare da maimaita allurai, rabin rayuwar daban.

Groupsungiyoyin haƙuri na musamman

Tsofaffi marasa lafiya

Ya kamata a rage yawan ƙwayar meldonium a cikin tsofaffi marasa lafiya da ke fama da hanta ko aikin koda, waɗanda ke da haɓaka bayyananniyar bioavailability.

Marasa lafiya tare da nakasa aiki na renal

Marasa lafiya tare da rauni na aiki na koda, wanda ke da haɓaka na bioavailability na fili, ya kamata ya rage kashi. Akwai hulɗa game da sake sake fasalin na renal na meldonium ko metabolites (alal misali, 3 - hydroxymeldonium) da carnitine, sakamakon abin da keɓaɓɓe na carnitine yana ƙaruwa. Babu wani tasiri kai tsaye na meldonium, GBB, da haɗin meldonium / GBB akan tsarin renin-angiotensin-aldosterone.

Marasa lafiya tare da nakasa aikin hanta

Marasa lafiya tare da aikin hanta mai rauni, wanda ke da haɓaka bayyanar bioavailability, ya kamata ya rage kashi na meldonium. Ba a lura da canje-canje ga alamu na ayyukan hanta a cikin mutane bayan amfani da allurai na 400-800 MG ba a lura. Ba zai yiwu a lalata kitse a cikin sel hanta ba.

Babu bayanai game da aminci da tasirin amfani da meldonium a cikin yara da matasa (a ƙarƙashin shekara 18), don haka amfani da meldonium a cikin wannan rukuni na marasa lafiya yana contraindicated.

Pharmacodynamics

Meldonium tsari ne mai mahimmanci ga carnitine, analog na tsarin gamma-butyrobetaine (GBB), a cikin abin da ake maye gurbin zarra na carbon ɗumama.

A karkashin yanayin karuwar kaya, meldonium ya dawo da daidaituwa tsakanin isar da bukatar oxygen na sel, yana kawar da tara kayan abinci mai guba a cikin sel, yana kare su daga lalacewa, haka kuma yana da tasirin tonic. Sakamakon amfani da shi, jiki yana samun ikon jure nauyin da sauri dawo da kayan ajiyar makamashi. Saboda waɗannan kaddarorin, ana amfani da meldonium don magance rikice-rikice iri iri na tsarin zuciya, samar da jini ga kwakwalwa, kazalika da haɓaka aikin jiki da na kwakwalwa. Sakamakon raguwa a cikin ƙwayar carnitine, GBB, wanda ke da kaddarorin vasodilating, yana haɓaka sosai. Idan mummunar cutar ischemic ta lalata myocardium, meldonium yana rage jinkirin samuwar yankin necrotic kuma yana gajarta lokacin murmurewa. Tare da rashin karfin zuciya, yana kara yawan kwanciyar hankali na mutum, yana kara karfin motsa jiki, da kuma rage yawan kamuwa da cutar angina. A cikin mummunar cuta da rashin lafiyar ischemic na wurare dabam dabam na haɓakar cerebral yana inganta wurare dabam dabam na jini a cikin ischemia, yana ba da gudummawa ga sake rarraba jini a madadin yankin ischemic. Game da rikice-rikice na jijiyoyin cuta (bayan hadarin cerebrovascular, ayyukan kwakwalwa, raunin kai, encephalitis na kashin kai), yana tasiri sosai kan aikin dawo da ayyukan jiki da na tunani yayin lokacin dawo da su.

Alamu don amfani

A cikin hadaddun far a cikin wadannan lamura:

cututtukan zuciya da tsarin jijiyoyin jiki: tsayayyar angina, raunin zuciya (Ciwan I-III mai aiki NYHA), cardiomyopathy, rikicewar aiki na zuciya da tsarin jijiyoyin jiki,

m da na kullum ischemic cuta na cerebral wurare dabam dabam,

rage aiki, jiki da kuma psycho-motsin rai,

yayin farfadowa daga rikicewar cerebrovascular, raunin kai da encephalitis.

Sashi da gudanarwa

Aiwatar da ciki. Ruwan ruwa ya hadiye shi. Ana iya amfani da maganin kafin ko bayan abinci. A dangane da yiwuwar sakamako mai karfafawa, ana bada shawarar yin amfani da miyagun ƙwayoyi da safe.

Manya

Cututtuka na zuciya da na jijiyoyin jini,rikicewar wurare dabam dabam

Maganin shine 500-1000 MG kowace rana. Ana iya amfani da kashi ɗaya na yau da kullun ko kuma ya kasu kashi biyu. Matsakaicin adadin yau da kullun shine 1000 MG.

Rage aikin, wuce gona da iri da lokacin dawowa

Yawan yana 500 MG kowace rana. Matsakaicin adadin yau da kullun shine 500 MG.

Tsawon lokacin jiyya shine makonni 4-6. Za'a iya maimaita karatun sau 2-3 a shekara.

Tsofaffi marasa lafiya

Tsofaffi marasa lafiya da ke fama da hanta da / ko aikin koda na iya buƙatar rage yawan ƙwayar meldonium.

Marasa lafiya tare da nakasa aiki na renal

Tunda an bayyana maganin ta hanyar kodan, marasa lafiya da ke fama da rauni na nakasassu daga mai rauni zuwa matsakaici mai rauni yakamata suyi amfani da karamin kashi na meldonium.

Marasa lafiya tare da nakasa aikin hanta

Marasa lafiya tare da rauni mai laushi zuwa matsakaici yakamata ya yi amfani da ƙananan ƙwayar meldonium.

Yawan yara

Babu wani bayani game da aminci da tasirin amfani da meldonium a cikin yara da matasa a ƙarƙashin shekara 18, don haka amfani da wannan magani ga yara da matasa ba su karɓa ba.

Side effects

- Hypersensitivity, rashin lafiyan dermatitis, rashes (janar / macular / papular), itching, urticaria, angioedema, anaphylactic dauki

- Jin tsoro, ma'anar tsoro, tunani mai zurfi, tashin hankali

- paresthesia, hypesthesia, tinnitus, vertigo, dizziness, damuwa damuwa, fainting, asarar sani

- bugun zuciya canje-canje, palpitations, tachycardia / sinus tachycardia, atrial fibrillation, arrhythmia, kirji rashin jin dadi / kirji zafi

- canzawa a cikin karfin jini, rikicin hauhawar jini, hyperemia, pallor na fata

- ciwon makogwaro, tari, dyspnea, apnea

- dysgeusia (dandano mai ƙarfe a bakin), asarar ci, amai, tashin zuciya, amai, tarin gas, zawo, zafin ciki, - ciwon baya, rauni na tsoka, raunin ƙwayar tsoka.

- rauni na gaba daya, rawar jiki, asthenia, edema, kumburin fuska, kumburi da kafafu, jin zafi, jin sanyi, gumi mai sanyi

- karkacewa a cikin tsarin electrocardiogram (ECG), hanzarta zuciya, eosinophilia

Contraindications

- Hypersensitivity ga aiki abu ko ga wani abu mai taimako na miyagun ƙwayoyi.

- haɓakawa a cikin matsin lamba na intracranial (a take hakkin ɓarin ciki, ciwan ciki).

- matsanancin hepatic da / ko gazawar kasa saboda rashin isasshen bayanan tsaro.

- ciki da lactation, saboda karancin bayanai game da amfani da magani a wannan lokacin.

- yara da matasa da ke ƙasa da shekara 18, saboda ƙarancin bayanai game da amfani da magani a wannan lokacin.

Mu'amala da Lafiya

Yana haɓaka sakamako na jijiyoyin bugun zuciya, wasu magungunan antihypertensive, bugun zuciya.

Ana iya haɗe shi da magungunan antianginal, anticoagulants, jami'in antiplatelet, magungunan antiarrhythmic, diuretics, bronchodilators.

Meldonium na iya haɓaka sakamakon magungunan da ke ɗauke da glyceryl trinitrate, nifedipine, beta-blockers, sauran magungunan antihypertensive, da kuma vasodilali na gefe.

A cikin marasa lafiya da rauni na zuciya shan meldonium da lisinopril a lokaci guda, an bayyana ingantaccen tasirin maganin haɗin gwiwa (vasodilation daga cikin manyan jijiyoyin hannu, haɓaka wurare dabam dabam da ingancin rayuwa, raguwar damuwa da damuwa ta jiki).

Lokacin amfani da meldonium a hade tare da orotic acid don kawar da lalacewa ta hanyar ischemia / farfadowa, an lura da ƙarin tasirin magunguna.

Sakamakon amfani da lokaci daya Kishinta kuma meldonium a cikin marasa lafiya da ƙarancin ƙwayar baƙin ƙarfe, abun da ke tattare da kitse mai a cikin sel jini ya inganta.

Meldonium yana taimakawa kawar da canje-canje na jijiyoyin jini a cikin zuciya wanda azidothymidine (AZT) ke haifar, kuma kai tsaye yana shafar halayen damuwa na rashin ƙarfi na oxidative wanda AZT ke haifar, wanda ke haifar da lalatawar mitochondrial. Yin amfani da meldonium a hade tare da AZT ko wasu magunguna don maganin cututtukan da aka samu na rigakafi (AIDS) yana da tasirin gaske game da maganin AIDS.

A cikin gwajin asara na ethanol, meldonium ya rage tsawon lokacin bacci. A lokacin raunin da ya faru ta hanyar pentylenetetrazole, an tabbatar da tasirin anticonvulsant na sakamako na meldonium. Bi da bi, lokacin da α-adrenoblocker yohimbine a kashi na 2 mg / kg da N- (G) -nitro-L-arginine synthase inhibitor a kashi 10 mg / kg ana amfani dasu kafin magani tare da meldonium, anticonvulsant sakamako na meldonium an rufe gaba daya .

Doaukar zubar da jini na meldonium na iya haɓaka cututtukan zuciya wanda cyclophosphamide ke haifar.

Rashin ƙwayar carnitine sakamakon amfani da D-carnitine (isomer mai ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa) -meldonium na iya haɓaka ƙwayar zuciya ta hanyar ifosfamide.

Meldonium yana da tasirin kariya idan akwai damuwa na zuciya da jijiyoyin jini wanda ya haifar da efavirenz.

Saboda yuwuwar ci gaban tachycardia na matsakaiciya da tawaitar jini, yakamata a yi taka-tsantsan lokacin da aka haɗu da magungunan da ke da tasiri iri ɗaya, gami da wasu magunguna waɗanda ke ɗauke da meldonium.

Umarni na musamman

Tare da tsawaita amfani da miyagun ƙwayoyi, marasa lafiya da cututtukan hanta da / ko cututtukan koda ya kamata a yi hankali (ya kamata a yi aikin saka idanu akan koda).

Meldonium ba magani bane na farko don cututtukan cututtukan jijiyoyin zuciya.

Siffofin tasiri na miyagun ƙwayoyi akan karfin tuka abin hawa ko ƙwararrun haɗari

Yakamata a yi taka tsantsan lokacin tuka abin hawa ko injunan da ke da haɗari.

Yawan abin sama da ya kamata

Ba a san shari'ar yawan adadin ƙwayar yawan ƙwayoyi tare da meldonium ba, ƙwayar ba ta da guba.

Tare da ƙarancin jini, ciwon kai, tsananin farin ciki, tachycardia, da rauni gaba ɗaya yana yiwuwa.

Game da cutar yawan ƙwayar cuta, ya zama dole don sarrafa aikin hanta da ƙodan.

Saboda ƙayyadadden dokar da aka ɗauka na magungunan ga sunadarai, hemodialysis ba mahimmanci bane.

Mai masana'anta

JSC "Grindeks", Latvia

Adireshin kungiyar da ta karbi bakuncin yankinJamhuriyar Kazakhstan tana da'awar daga masu sayayya kan ingancin samfur

Wakilcin JSC "Grindeks"

050010, Almaty, Dostyk Ave., kusurwar ul. Bogenbai Batyr, d. 34a / 87a, ofishin mai lamba 1

Pharmacodynamics

Meldonium (MILDRONAT ®) analog ne mai tsari na gamma-butyrobetaine - wani abu ne da aka samo a cikin kowane sel na jikin mutum.

A karkashin yanayin karuwar kaya, MILDRONAT ® ya dawo da daidaituwa tsakanin isar da bukatar oxygen na sel, yana kawar da tarin kayan abinci mai guba a cikin sel, yana kare su daga lalacewa, kuma yana da tasirin tonic. Sakamakon amfani da shi, jiki yana samun ikon jure nauyin da sauri dawo da kayan ajiyar makamashi.

Saboda waɗannan kaddarorin, ana amfani da miyagun ƙwayoyi MILDRONAT to don magance cuta daban-daban na CVS, samar da jini ga kwakwalwa, kazalika da haɓaka aikin jiki da na kwakwalwa. Sakamakon raguwa a cikin taro na carnitine, gamma-butyrobetaine tare da kaddarorin vasodilating yana haɓaka mai ƙarfi. Idan mummunan lalacewa na ƙwayar cuta na myocardium, MILDRONAT ® yana rage jinkirin samuwar yankin necrotic kuma yana gajarta lokacin murmurewa. Tare da rashin karfin zuciya, yana kara yawan kwanciyar hankali na mutum, yana kara karfin motsa jiki, da kuma rage yawan kamuwa da cutar angina. A cikin mummunar cuta da rashin lafiyar ischemic na wurare dabam dabam na ƙwayar cuta, ƙwayar MILDRONAT ® tana inganta jini wurare dabam dabam na ischemia, tana haɓaka sake rarraba jini a madadin yankin ischemic. Magungunan yana kawar da rikice-rikice na aiki na tsarin juyayi a cikin marasa lafiya tare da shan barasa tare da ciwo na cirewa.

Alamun magungunan MILDRONAT ®

hadaddun farji na cututtukan zuciya da jijiyoyin jini (angina pectoris, infarction myocardial),

raunin zuciya da kasala da rashin lafiyar zuciya akan tushen rikicewar cuta,

hadaddun hanyoyin magance cututtukan jijiyoyi masu rauni na rashin wadatuwa da ke bayarwa zuwa ga kwakwalwa (bugun jini da karancin hanji),

hemophthalmus da kuma bashin jini na daban-daban etiologies, thrombosis na tsakiya na jijiya da kuma rassan, retinopathy na daban-daban etiologies (ciwon sukari, hauhawar jini),

Saukar nauyin kwakwalwa da na jiki (gami da cikin 'yan wasa) (ƙwayar za ta iya ba da sakamako mai kyau yayin gudanar da kula da doping (duba. "Umarni na musamman"),

janyewar ciwo a cikin matsalar shan barasa (a hade tare da takamaiman magani don shan giya).

Haihuwa da lactation

Ba a yi nazarin amincin amfani da mata masu juna biyu ba, don haka ya yi amfanida amfani don hana cutarwa mai yiwuwa ga tayin.

Ba a bincika rarraba magungunan MILDRONAT ® tare da madara da tasirinsa ga matsayin lafiyar jariri ba, saboda haka, idan ya cancanta, ya kamata a dakatar da ciyar da jariri.

Haɗa kai

Ana iya haɗe shi da magungunan antianginal, anticoagulants, jami'in antiplatelet, magungunan antiarrhythmic, diuretics, bronchodilators.

Yana haɓaka aikin glycosides na zuciya.

Saboda yuwuwar ci gaban tachycardia na matsakaiciyar jini da na jijiya, yakamata a yi taka tsantsan lokacin da aka haɗa shi da nitroglycerin, nifedipine, alpha-blockers, sauran magungunan antihypertensive da na vasodilali na gefe, kamar yadda MILDRONAT ® yana inganta tasirin su.

Fom ɗin saki

Magani don intramuscular, intravenous da kuma parabulbar management, 100 mg / ml. 5 ml a cikin gilashin gilashin launi mara launi na aji hydrolytic I tare da layi ko hutu.

5 amp kowane. a cikin kwantena na sel wanda aka yi da fim din PVC ko fim ɗin PET da aka rufe (pallet). A 2 ko 4 (kawai ga masana'antun ZAO Santonika da HSBC Pharma sro) fakiti na sel (pallets) a cikin fakitin kwali.