Lozap AM > Jiyya da rigakafin

Rashin hankali ga kowane ɓangaren magungunan.

Ciki da lokacin shayarwa.

Shekaru har zuwa shekaru 18 (ba a kafa ingantaccen aiki da amincin amfani ba).

Yin amfani da lokaci guda tare da aliskiren ko aliskiren-dauke da kwayoyi a cikin marasa lafiya tare da ciwon sukari mellitus da / ko rauni na aikin renal (GFR kasa da 60 ml / min / 1.73 m2) (duba CIKIN CIKIN SAURAN LITTAFAI).

Rashin ƙarfi ga aikin hanta (babu gogewa tare da amfani).

Hagu kwarangwal mai fita daga ciki (misali, matsanancin aortic stenosis).

Ciwon zuciya mai rauni a cikin zuciya bayan tsananin rauni.

Yi amfani da a cikin marasa lafiya da ke fama da rauni na aikin renal (keɓantar da keɓaɓɓen ƙasa da 20 ml / min) ko marasa lafiya akan cutar sankara.

Aikin magunguna

Allunan maganin suna dauke da sinadarai guda biyu masu aiki a cikin abubuwan da ke tattare da Lozap AM tare da kayan aiki mai dacewa don aiwatarwa don inganta karfin jini (BP) a cikin marasa lafiya tare da hauhawar jijiya (AH): potassium losartan, an angiotensin II receptor antagonist (ARA II), da amlodipine, mai toshe ' jinkirin 'tashoshi na alli (BMCC).

Side effects

Daga tsarin juyayi

Rashin daidaituwa: rauni, rashin jin daɗi a cikin yanki na kirji, ciwon kirji, jin saurin satiety, yanki na gefe.

Daga cikin hanji

Rashin daidaituwa: rashin jin daɗi a cikin ciki, dyspepsia, tashin zuciya, reflux esophagitis.

A wani ɓangaren fata da ƙwaƙwalwar fata

Rashin daidaituwa: itching fata (na kowa), urticaria (na gaba ɗaya).

Daga zuciya

Rashin daidaito: palpitations.

Daga tasoshin

Rashin daidaituwa: fitar da fuska, zubar jinin orthostatic.

Daga tsarin numfashi, kirji da gabobin jiki

Nau'in ji da ji na labyrinthine

Daga kodan da hujin hanji

Umarni na musamman

A cikin marasa lafiya da rage BCC (alal misali, karbar magani tare da manyan allurai na diuretics) ko kuma tare da matsanancin aortic stenosis, hypotension artpot hypotension na iya faruwa. Gyara irin waɗannan halayen dole ne a yi su kafin ranar Lozap AM ko a fara jiyya tare da ƙananan kashi na ƙarshen.

Formaddamar da tsari da abun da ke ciki

Ana samar da miyagun ƙwayoyi a cikin nau'ikan allunan da aka sanya fim: biconvex, oblong, sashi na 5 MG + 50 MG - kusan fari ko fari, a gefe ɗaya tare da zane mai zane "AT1", sashi na 5 MG + 100 MG - ruwan hoda ko kodadde ruwan hoda, akan ɗayan bangarorin an zana su da "AT2" (inji mai kwakwalwa 10 a cikin alkuki mai haske, inji mai kwakwalwa 300 a cikin kwalban filastik, a cikin kwali na kwali 1 ko roba 1, ko kwalban 1 da umarnin don amfani Lozap AM).

Kwamfutar hannu 1 ya ƙunshi:

abubuwa masu aiki: amlodipine camsylate - 7.84 MG (wanda yake daidai da amlodipine a cikin adadin 5 MG), potassium losartan - 50 MG ko 100 MG,
ƙarin abubuwan da aka gyara: sitaci carboxymethyl sitaci, butylhydroxytoluene, microcrystalline cellulose, povidone K30, mannitol, magnesium stearate, crospovidone,
rigar fim: hyprolose, talc, hypromellose, titanium dioxide, ban da sashi na 5 MG + 100 MG - dyes iron oxide yellow da iron oxide ja.

Pharmacodynamics

Lozap AM - magani ne mai haɗari mai haɗari wanda ya haɗa da jinkirin tashar alli mai sauƙi (BMCC) da mai karɓar maganin antagonistin II (ARA II). Dangane da sakamakon binciken wanda masu aikin sa kai na lafiya suka shiga, Lozap AM a cikin adadin 5 mg + 50 mg da 5 mg + 100 mg shine ingantaccen abu tare da haɗarin amfani da daidaitattun allurai na amlodipine camsylate da potassium losartan azaman shirye-shirye daban.

Hakanan an gano cewa Allunan kwayoyi na Lozap AM, wanda amlodipine camsylate ya ƙunshi a cikin kashi 5 MG, sune bioequurate to amlodipine besilate allurai a cikin wannan adadin.

Hanyar aiwatar da maganin Lozap AM

Abubuwan da ke aiki na Lozap AM - amlodipine (BCC) da losartan (ARA II) suna da ingantaccen tsarin aiki na aiki da nufin ƙarfafa karfin jini (BP) a cikin marasa lafiya tare da cutar hawan jini (AH). Losartan yana hana sakamako na vasoconstrictor na angiotensin II da sakin na karshen-mai sulhuntawa na aldosterone ta hanyar daɗa ɗaukar nauyin angiotensin II ga masu karɓar AT.₁. Amlodipine yana nufin vasodilators na jijiyoyin hannu kuma suna yin kai tsaye a kan madaidaicin tsokoki na bangon jijiyoyin jini, wanda ke haifar da rauni na juriya da raguwar haɓakar jini.

Angiotensin II yana nuna tasirin vasoconstrictor (vasoconstrictive) mai ƙarfi, kuma shine babban aikin hormone na tsarin renin-angiotensin-aldosterone (RAAS) da kuma mahimman mahimmancin ƙwayar cuta don hauhawar jini. Haɗawa zuwa masu karɓar AT₁karkara a cikin kyallen takarda mai kyau na jijiyoyin jijiyoyin jini, kodan, glandon ciki da zuciya, angiotensin II yana samar da vasoconstriction da kuma sakin aldosterone zuwa cikin jini. Hakanan, wannan hormone yana haifar da haɓaka ƙwayoyin tsoka mai santsi.

Losartan, memba ne na ƙungiyar masu zaɓin adawa na ARA II (AT₁masu karɓa), yana nuna babban tasiri yayin ɗauka da kyau. Wannan abun da yake aiki da metabolite metabolite (E-3174) a cikin fitsari da kuma a cikin vivo suna lalata duk mahimman tasirin angiotensin II, ba tare da la’akari da hanya ba ko tushen tushenta. Losartan selectively ƙulla wa AT₁-receptors, yayin da baya ɗaure ko hana masu karɓuwa na wasu kwayoyin homon da ion tashoshin da ke tsara ayyukan tsarin jijiyoyin jini (CCC). Hakanan, bangaren da ke aiki ba zai tasiri aikin aikin angiotensin wanda ke canza enzyme (ACE) - kininase II, wanda ke lalata bradykinin. Don haka, sakamakon losartan ba shi da alaƙa da tasirin da ya danganta ga hanawar AT.₁masu karɓa (gami da bayyanar edema).

Amlodipine asali ne na dihydropyridine, mai adawa da ion alli ko BMCC, yana hana shigowar membobin ion alli zuwa kadarin cardioyocytes da jijiyoyin jijiya mai santsi. Ana iya ɗauka a kan tushen gwaji cewa wannan abu yana iya ɗaurewa a cikin masu karɓar tashoshi na jinkirin jinkirin tare da shafuka masu dihydropyridine da wuraren da ba a dihydropyridine ba. Amlodipine a hankali yana hana zirga-zirgar alli ta hanyar membranes, yana shafar ƙwayoyin tsoka mai santsi fiye da ƙwayoyin myocardial. Kayan aiki baya tasiri matakin ganina a cikin jini.

Losartan, kamar amlodipine, yana saukar da karfin jini sakamakon rauni na tsayuwa a waje. Haramcin shigar azzakari cikin alli a cikin tantanin halitta da raguwa a cikin tasirin vasoconstrictor wanda ya haifar da ayyukan angiotensin II sune hanyoyin haɗin gwiwa.

Losartan (ƙarin tasirin magunguna)

Losartan yana hana haɓakar hauhawar jini na systolic (DBP) da diastolic (dAD) saboda haɓakar angiotensin II. Bayan kai iyakar maida hankali (C_max) losartan a cikin plasma bayan shan kashi na 100 MG, na sama sakamako na angiotensin II ana shafe shi da kusan 85%, kuma bayan sa'o'i 24 - zuwa 26-39%, bi da bi, bayan guda ɗaya ko mai yawa.

Tarewa na samar da renin ta hanyar angiotensin II (rashi mara kyau), wanda aka kawar dashi ta losartan, yana haifar da karuwa a cikin aikin plasma renin (ARP), wanda ke haifar da karuwa a cikin matakan plasma angiotensin II. A cikin makonni 6 na cin 100 mg na losartan a cikin marasa lafiya tare da hauhawar jini a lokacin da sinadarin C ya kai_max akwai karuwa a cikin ƙwayar plasma na angiotensin II sau 2-3, kuma a wasu lokuta har ma da mafi girma, akasari tare da hanya na kwantar da hankali na kwanaki 14. Koyaya, an lura da tasirin antihypertensive da raguwa a cikin matakan plasma aldosterone bayan makonni 2 da 6 na jiyya, yana nuna ingantaccen shinge na masu karɓar angiotensin II. Bayan dakatar da kulawar losartan, yawan ƙwaƙwalwar angiotensin II da ARP ya ragu a cikin kwanaki 3 zuwa ƙimar farko.

Lokacin da aka gwada tasirin losartan a allurai na 20 da 100 MG tare da tasirin inhibitor na ACE, an gano cewa losartan, saboda takamaiman tsarin aikin, ya toshe tasirin cutar angiotensin I da II ba tare da tasiri bradykinin ba. Mai hanawa ACE hanawa martani ga angiotensin I kuma yana ƙaruwa da mummunan tasirin da aikin bradykinin yayi ba tare da canza zafin amsa ga angiotensin II ba, wanda ke tabbatar da bambancin harhada magunguna tsakanin masu hana ACE da masu amfani da losartan.

Tasirin antihypertensive na losartan, matakin sa da kuma aiki na metabolite a cikin plasma yana ƙaruwa tare da kara yawan ƙwayoyi. Dukkanin losartan da aiki metabolite suna da tasirin gaske.

Dangane da bayanan binciken da aka samu, wanda maza masu lafiya suka shiga, tare da gudanar da maganin losartan a cikin kashi 100 na abinci a cikin babban abinci mai gishiri da ƙananan gishiri, sinadarin bai shafi ƙimar filtatt ɗin na duniya ba (GFR), filarfin filtration, da ingantaccen kwararar haɓakar plasma na renal. Losartan ya nuna sakamako na rashin lafiyar, mafi mahimmanci tare da abincin gishiri mai ƙoshin abinci, kuma ya haifar da haɓakar kumburi na urinary acid excretion daga kodan.

A gaban proteinuria (aƙalla 2 g / 24 hours) a cikin marasa lafiya tare da hauhawar jini, ba tare da ciwon sukari ba, karɓar losartan a kashi 50 na MG don makonni 8 tare da karuwa a cikin kashi na yau da kullun zuwa 100 MG, raguwar proteinuria (ta 42%) an rubuta, kuma haka kuma wani yanki na juzu'i na albumin da immunoglobulin G (IgG). A cikin marasa lafiya na wannan rukunin, an rage rage sashi kuma aka inganta GFR.

Marasa lafiya a cikin postmenopausal tare da hauhawar jini wanda ya ɗauki 50 MG na losartan kowace rana don makonni 4 bai bayyana tasirin miyagun ƙwayoyi akan matakan tsari da na yara na prostaglandins (PG) ba.

Magungunan da aka ɗauka kafin abinci (a kan komai a ciki), a cikin allurai na yau da kullun har zuwa 150 MG, bai haifar da canje-canje na asibiti ba a cikin taro na triglycerides, jimlar cholesterol (Chs) da Chs mai yawa na lipoproteins (HDL), kuma kuma bai shafi matakin glucose a cikin jini ba. Ayyukan wakilin ya ba da raguwa a cikin adadin ƙwayar uric acid a cikin jini (mafi yawanci ƙasa da 0.4 mg / dl), wanda ya kasance a lokacin da aka tsawanta.

A cikin makonni 12 na kwatankwacin binciken da ya haɗa da marasa lafiya tare da rauni na ventricular hagu na aji na II - IV bisa ga rarrabuwa na Yorkungiyar New York na Cardiology (NYHA) suna karɓar diuretics da / ko glycosides na cardiac, sakamakon losartan a allurai na yau da kullun na 2.5, 10, 25 an kwatanta shi. da 50 MG tare da tasirin motsa jiki. Magunguna a cikin allurai na 25 da 50 MG sun nuna ingantaccen neurohormonal da aikin hemodynamic a duk binciken. Losartan ya haɓaka ƙayyadadden zuciya kuma ya rage matsin lamba a cikin ƙwayar jijiyoyin jiki, haka kuma ya raunana jimlar bugun jini na jijiyoyin jini (OPSS), rage matsin lamba na jini da bugun zuciya (HR). A cikin wa] annan marasa lafiyar, abin da ya faru ta hanyar jijiyoyin jini ya dogara da kashi-kashi. Tasirin neurohormonal ya kasance raguwa a cikin matakan jini na norepinephrine da aldosterone.

Amlodipine (ƙarin tasirin magunguna)

Yin amfani da amlodipine a cikin hanyoyin kwantar da hankali a cikin marasa lafiya tare da hauhawar jini yana haifar da vasodilation, kuma a sakamakon raguwa da karfin jini a cikin kwance da matsayi na tsaye. Wannan mummunar tasiri na abu mai aiki ba ya hade da manyan canje-canje a cikin yawan bugun zuciya ko matakan catecholamine na jini tare da jinya na tsawan lokaci. Kodayake tsarin guda ɗaya na ciki (iv) na amlodipine ya nuna raguwa a cikin karfin jini da karuwa a cikin zuciya yayin karatu, maimaita maganin baka na maganin ba ya haifar da canje-canje mai mahimmanci a cikin bugun zuciya ko hawan jini a cikin marasa lafiya tare da hawan jini na al'ada kuma tare da angina pectoris.

A bango na dogon lokaci na baka na amlodipine sau ɗaya a rana, ana lura da tasirin maganin ta aƙalla awanni 24. Matsayin plasma na abu mai aiki a cikin jini yana daidaita da babban tasiri a cikin matasa da tsofaffi marasa lafiya. Har ila yau, alamomin raunin hawan jini yayin amfani da amlodipine suna da alaƙa da tsananin ƙaruwar karuwar da aka lura dashi kafin magani. A cikin marasa lafiya tare da DBP 105-115 mm Hg. Art. (AH na tsananin tsananin matsakaici) an lura da tasirin rigakafin ƙwayar cuta kusan 50% fiye da wanda ke cikin marasa lafiya tare da DBP na 90-104 mm Hg. Art. (AH na tsananin rauni). A gaban daidaituwa na jini a cikin marasa lafiya, ba a yi amfani da canji mai mahimmanci na asibiti ba.

A cikin marasa lafiya tare da hauhawar jini a kan asalin aikin koda na al'ada, gudanar da amlodipine a cikin hanyoyin kwantar da hankali ya raunana juriya na jijiyoyin jini na jini, da ƙaddamar da ƙwayar cutar plasma mai ƙwaƙwalwa mai haɓaka da haɓaka GFR, ba tare da canza fraarfin filtration ko proteinuria ba.

A cikin marasa lafiya suna ɗaukar amlodipine, tare da aiki na ventricular al'ada, sigogi na hemodynamic na zuciya a hutawa kuma a ƙarƙashin kaya ya nuna ƙarancin ƙima a cikin ƙididdigar bugun zuciya ba tare da wani canji mai mahimmanci ba a cikin yawan hauhawar jini a farkon lokaci na fitar da jini a cikin rami na ventricle na hagu, ko ƙara yawan ventricle / end DP. Dangane da ƙididdigar ma'aunin hemodynamic, abu mai aiki a cikin allurai warke ba ya nuna mummunar tasiri a cikin masu sa kai na lafiya, koda kuwa tare da ckers-blockers. A lokaci guda, an lura da irin wannan sakamakon a cikin marasa lafiya da raunin zuciya a cikin lokacin biyan diyya ko a cikin marasa lafiya masu lafiya lokacin amfani da kwayoyi tare da tasirin rashin ƙarfi na inotropic.

Amfani da gibiyoyi na wucin gadi (AV conduction) ko aikin sinadarin kumburi a cikin masu aikin sa kai na lafiya bai shafi amlodipine ba. A / a cikin gabatarwar miyagun ƙwayoyi a cikin kashi 10 MG tare da angina mai tsayayye ba shi da tasiri sosai a kan wasan kwaikwayon AH da H-V da kuma lokacin dawowa da ƙonewa na firikwensin bayan bugun zuciya. An lura da irin wannan sakamakon a cikin marasa lafiya suna shan amlodipine a hade tare da β-blockers. A cikin binciken a cikin marasa lafiya tare da hauhawar jini ko angina pectoris tare da haɗakar gudanarwar amlodipine tare da β-blockers, ba a lura da tasirin da ba a buƙata ba a kan sigogi na electrocardiogram (ECG). A cikin marasa lafiya tare da angina pectoris, yin amfani da amlodipine bai shafi tsaka-tsakin ECG ba kuma ba ya haifar da babban matakin AV toshe ba.

Pharmacokinetics

Bayan sarrafawa na baki, yana da kyau kuma yana ɗaukar tasirin farkon sashi ta hanta tare da samuwar ƙwayoyin metabolites guda biyu masu aiki da sauran metabolites marasa aiki. Don losartan a cikin kwamfutar hannu, tsari mai lalacewa na kusan kashi 33% shine sifofi. Losartan da aiki na metabolite sun kai matsakaicin darajar Cmax 1 da sa'o'i 3-4 bayan gudanarwa, bi da bi. Cin abinci ba shi da tasiri a asibiti a cikin bayanan tattarawar abubuwan plasma.

Tare da kariyar plasma (mafi yawa tare da albumin), losartan da aiki metabolite suna ɗaure ƙasa da 99%. Juzu'i Rarraba (V_d) losartan shine lita 34. Dangane da binciken dabbobi, abu mai wuya ya ratsa shingen jini-BBB. Babu wata alama mai tarin yawa a cikin ƙwayar plasama na losartan da babban metabolite lokacin amfani da miyagun ƙwayoyi a cikin kashi 100 MG sau ɗaya a rana.Sakamakon sarrafa maganin baka na losartan a cikin allurai har zuwa 200 MG, sinadarin da aiki metabolite yana nuna magungunan likitanci na layi.

Tare da yin amfani da iv ko na baka na losartan, kusan 14% na maganin sa ana canza shi zuwa cikin metabolite mai aiki. Bayan sarrafa baki ko gudanarwa na iv na 14 C na losartan (wanda aka yi masa alama da carbon radioactive), ƙwaƙwalwar ƙwayar plasma radioactivity ana haifar da farko ta kasancewar kasancewar losartan da kuma samfurin aikinsa. Matsakaicin, 1% na ɗaliban da aka yi nazari sun nuna ƙarancin canji na juyawa losartan cikin metabolite mai aiki. Baya ga samuwar karshen lokacin canzawar metabolism na losartan, an samar da manyan abubuwa biyu na biologically marasa aiki wadanda suka tashi saboda hydroxylation na sarkar butyl, kuma daya sakandare - N-2-tetrazole-glucuronide.

Theaddamarwar plasma na losartan da metabolite mai aiki shine kimanin 600 da 50 ml / min, da na koda - kimanin 74 da 26 ml / min, bi da bi. Lokacin da aka sha shi a baki, losartan ne ya raba shi da ƙodan a cikin yanayin da ba a canza shi ba kusan kashi 4% na kashi kuma a cikin nau'in metabolite mai aiki - kusan 6% na kashi. Magungunan losartan da aiki na metabolite a cikin ƙwayar plasma suna rage yawan polyexponally tare da kashi na ƙarshe na rabin rayuwar (T_1/2) kamar awa 2 da 6-9, bi da bi. Losartan da metabolite din su ne ke rabuwa da kodan kuma ta cikin hanji da bile. Bayan gudanar da maganin baka na losartan 14 C a cikin maza, an sami kimanin 35% na aikin rediyo a cikin fitsari da kuma 58% a cikin feces, bayan aikin iv na kusan 43% na aikin rediyo a cikin fitsari da kuma 50% a cikin feces.

A cikin hauhawar jini a cikin mata, yawan ƙwayar cutar plasama ya ninka sau 2 sama da na maza. Matakan jini na aiki na maza da mata iri daya ne. Koyaya, wannan bambancin magunguna ba shi da mahimmanci a asibiti.

Tare da gudanar da baka na amlodipine a allurai na warkewa, ana lura da Cmax bayan awanni 6-12. Cikakken bioavailability shine kashi 64-90% na maganin. Rashin abinci na amlodipine mai zaman kansa ne daga cin abinci.

A lokacin nazarin, an gano cewa a cikin marasa lafiya tare da hauhawar jini kimanin 93% na amlodipine da ke ɗaure sunadaran plasma. Tare da yin amfani da yau da kullun, ana lura da tsinkaye (Css) na amlodipine a cikin plasma bayan kwanaki 7-8.

Kimanin 90% na amlodipine an metabolized a cikin hanta don metabolites, kusan 10% na kashi an cire shi da kodan, kuma 60% a cikin hanyar metabolites.

Amlodipine daga plasma an cire shi a cikin matakai biyu, kashi na ƙarshe T_1/2 na iya bambanta daga awanni 30 zuwa 50.

Lozap AM, umarnin don amfani: hanyar da sashi

Ana ɗaukar magungunan Lozap AM a baki, ba tare da la'akari da lokacin cin abinci ba, tare da ruwa mai yawa. Za'a iya amfani da maganin a hade tare da sauran magungunan antihypertensive.

Marasa lafiya waɗanda suka kasa cimma daidaitaccen iko na karfin jini yayin amfani da losartan ko amlodipine azaman magungunan monotherapy na iya canzawa zuwa haɗuwa da haɗuwa da Lozap AM. Theauki magani sau 1 a kowace rana don kwamfutar hannu 1, matsakaicin kashi shine 5 + 100 MG sau ɗaya a kowace awa 24.

Ana ba da shawarar Lozap AM 5 + 50 mg ga marasa lafiya waɗanda ba su sami isasshen ikon hawan jini lokacin amfani da amlodipine a kashi na 5 MG ko losartan a kashi na 50 MG a cikin monotherapy.

Ana ba da shawarar Lozap AM 5 + 100 mg ga marasa lafiya waɗanda ba su sami isasshen ikon kula da karfin jini ba yayin amfani da losartan a kashi na 100 MG ko magani Lozap AM 5 + 50 mg. Marasa lafiya da ke shan amlodipine da losartan azaman magunguna daban za su iya canzawa zuwa Lozap AM (dauke da allurai iri na amlodipine da losartan) don haɓaka riko da magani.

Idan shan Lozap AM ya zama dole ga marasa lafiya da rage BCC, tare da aikin hanta mai rauni ko tsofaffi marasa lafiya, to kafin fara magani tare da hada magunguna tare da tsayayyen allurai na amlodipine da losartan, zaɓin mutum ɗaya na allurai na waɗannan abubuwan masu aiki ya kamata a aiwatar.

Marasa lafiya tare da rage yawan BCC (ciki har da waɗanda ke karɓar magani tare da diuretics a cikin allurai) ana bada shawarar ɗaukar losartan a farkon kashi 25 MG sau ɗaya a rana a matsayin maganin monotherapy, saboda Lozap AM bashi da sashi wanda ya haɗa da 25 mg na losartan.

Yawan abin sama da ya kamata

Babu wani bayani game da yawan adadin da ya wuce na AMARYA.

Bayanai game da yawan ruwan sha na losartan yana da iyakantuwa, mai yiwuwa tare da wannan yanayin, tachycardia da raguwar alama a cikin karfin jini na iya faruwa, abin da ya faru na bradycardia mai yiwuwa ne sakamakon tashin hankali na parasympathetic. An wajabta maganin Symptomatic, hemodialysis ba shi da tasiri.

Bayyanar cututtukan ƙwayar cuta mai yawa na amlodipine na iya zama mai wucewa na vasodilation tare da raguwa sosai a cikin karfin jini da yiwuwar bayyanar reflex tachycardia. Akwai rahotanni na tsawan tsayi da mummunan tasirin tsarin, ciki har da girgiza tare da sakamako mai m. Game da yawan abin sama da ya kamata, idan ya cancanta, an sanya rigakafin hanji da kuma ci da gawayi a ciki. Idan an gabatar da wani babban adadin ƙwayar cuta mai yawa, ya zama dole don saka idanu kan sutturar numfashi da matakan hemodynamic, kuma sau da yawa suna auna karfin jini. A kan asalin abin da ya faru na rashin lafiyar jijiyoyin jini, yakamata a tabbatar da ingantaccen tsarin samar da ruwa mai gudana, yakamata a inganta gindin mara lafiya sannan a dauki sauran matakan daidaituwa don kula da rashin lafiyar jiki. Idan matakan Conservative ba su da tasiri, za a iya tsara magungunan phenylephrine ko wasu wakilai na vasoconstrictor, gwargwadon diuresis da bcc.

An kawar da tasirin tashoshi na alli ta hanyar iv jiko na alli gluconate. Hanyar hemodialysis ba ta da tasiri, saboda amlodipine yana da babban matsayi na ɗaure wa garkuwar plasma.

Tasiri a kan ikon tuka motoci da abubuwa masu rikitarwa

Ba a gudanar da nazarin tasirin Lozap AM akan iya tuƙin motoci da sauran hanyoyin da ke da rikitarwa ba. Koyaya, yakamata a ɗauka a cikin zuciya cewa a lokacin jiyya wasu cututtukan da ba a so na iya bayyana waɗanda zasu iya cutar da hanzarin halayen psychomotor da taro.

Haihuwa da lactation

Amincewar Lozap AM yayin daukar ciki da lokacin shayarwa yana daukar ciki. Magunguna waɗanda ke shafar RAAS kai tsaye zasu iya haifar da mummunar illa da mutuwa ga tayin da ke tasowa. Lokacin da ake binciken ciki, dole ne a cire maganin nan da nan. Idan ya cancanta, canza zuwa madadin maganin rigakafi tare da magani wanda ke da ingantaccen bayanin martaba don amfani yayin ciki.

Duk da cewa mata masu juna biyu ba su da gogewa na shan Lozap AM, nazarin dabbobi sun gano cewa losartan na iya haifar da mummunan rauni na ciki da na jarirai da mutuwar tayi. Ana ɗauka cewa tsarin waɗannan abubuwan mamakin yana da alaƙa da tasiri akan RAAS.

Yin amfani da losartan a cikin watanni na biyu da na uku na ciki yana lalata aikin kodan kuma yana kara hadarin da mutuwar tayi da jarirai. Abun da ya faru na oligohydramnios na iya hade da hypoplasia na huhu tayi da kuma nakasar kasusuwanta. Rashin halayen da ba a so saboda losartan a cikin jarirai na iya haɗawa da jijiyoyin jini, hypoplasia kashi, rashin lafiyar koda, gazawar koda, da mutuwa. Idan magani tare da kwayoyi da suka shafi RAAS a cikin watanni biyu na uku da na uku na ciki ba za a iya maye gurbinsu da wani madadin magani ba, ya kamata a sanar da mai haƙuri game da haɗarin shan waɗannan magungunan don tayi.

Ba a gudanar da ingantaccen nazari da isasshen binciken amfanin amlodipine a cikin mata masu juna biyu ba.

Ba'a san ko losartan da amlodipine sun shiga cikin madara ba. Idan kana buƙatar shan Lozap AM yayin shayarwa, ya kamata ka daina shayar da nono.

Babu wani bayani game da tasirin losartan akan haihuwa. Akwai rahotannin lokuta na canje-canje masu canzawa na kwayar halitta a cikin maniyyi, wanda aka lura a wasu marasa lafiya da ke karɓar BMCC. Bayanan asibiti da ake buƙata don tantance tasirin amlodipine akan haihuwa ba su da isasshen.

Yi amfani da ƙuruciya

Amfani da Lozap AM a cikin yara da matasa ba su da wata ma'amala, saboda a cikin marasa lafiya da ke ƙasa da shekaru 18 ba a kafa aminci da tasiri na maganin ƙwayoyi ba.

Jariri wanda mahaifiyarsa suka dauki ARA II yayin daukar ciki (gami da losartan) suna buƙatar sa ido sosai don magance hyperkalemia, oliguria da hypotension. Idan an gano rikice-rikice na sama a cikin waɗannan yara, ana wajabta maganin warkewa don kula da ƙanshin koda da hawan jini. Ana buƙatar buƙatar watsawar jini ko dialysis don hana hypotension art / da kuma ko daidaita al'ada aikin koda.

Tare da nakasa aiki na koda

A gaban raunin lalacewar na yara (CC a ƙasa da 20 ml / min) ko kuma buƙatar jiyya ta hemodialysis, shan Lozap AM yana contraindicated. Ga marasa lafiya da matsakaitan rauni na aikin keɓaɓɓen magani, magani ba tare da shawarar ba da shawarar. Ana buƙatar taka tsantsan don ɗaukar magani don ƙwanƙwasa ƙwayar koda na jijiya ko ƙwaya biyu na jijiyoyin koda, gazawar koda, yanayin bayan dasawa koda. Ba a buƙatar daidaita sashi ga marasa lafiya tare da raunin aikin koda koda idan CC - 20-50 ml / min.

Tare da aikin hanta mai rauni

A cikin gazawar hanta mai ƙarfi (fiye da maki 9 akan sikelin Yara-Pugh) - Lozap AM yana contraindicated, marasa lafiya waɗanda ke fama da rauni na hanta mai sauƙi da matsakaici (ƙasa da maki 9 akan sikelin Yara-Pugh) ya kamata suyi amfani da wakili na antihypertensive tare da taka tsantsan.

Dangane da bayanan pharmacokinetic wanda ya nuna gagarumar karuwa a cikin ƙwayar plasma losartan a cikin marasa lafiya da ke fama da cutar cirrhosis, ba a ba da shawarar marasa lafiya da tarihin cirrhosis ko tsananin lalata hanta. Suna buƙatar sadar da losartan a cikin ƙananan allurai (25 mg sau ɗaya a rana) a cikin monotherapy.

Sakamakon gaskiyar amlodipine shine yawancin metabolized a cikin hanta, a cikin marasa lafiya tare da raunin T_1/2 daidai yake da awanni 56. Idan ya zama dole don amfani da amlodipine a cikin marasa lafiya tare da mummunan rauni na rashin hanta, ana ba da shawarar ƙaddamar da adadinsa a hankali.

Yi amfani da tsufa

Lokacin gudanar da bincike na asibiti a cikin marasa lafiya fiye da shekaru 65, ba a sami fasali game da tasiri da amincin maganin losartan. Tunda a cikin tsofaffi marasa lafiya, saboda ragewar amlodipine, yankin da ke ƙarƙashin tsarin lokacin taro (AUC) yana ƙaruwa da kusan 40-60%, ana bada shawarar yawanci shan shi tare da maganin yau da kullum na 2.5 MG, amma tunda Lozap AM ya ƙunshi 5 mg na amlodipine, irin waɗannan marasa lafiya ya kamata su ɗauki amlodipine azaman maganin monotherapy.

Hulɗa da ƙwayoyi

Ba a gudanar da nazarin hulɗa na Lozap AM tare da wasu kwayoyi ba.

Matsalolin da za a iya yi na cudanya da losartan tare da amfani tare da wasu magunguna / jamiái:

digoxin, hydrochlorothiazide, cimetidine, warfarin, phenobarbital: ba'a gano ma'amala mai mahimmanci ta hanyar asibiti,
rifampicin: matakin losartan a cikin jini yana raguwa,
erythromycin: Babu wani tasiri mai tasiri a cikin magungunan likitancin losartan lokacin da aka sha shi da baka,
ketoconazole: babu wani tasiri a kan metabolism na losartan bayan gwamnatin iv har zuwa samuwar metabolite mai aiki,
fluconazole (inhibitor na isoenzyme CYP2C9): maida hankali na aiki metabolite na losartan yana raguwa, mahimmancin magunguna na haɗin gwiwar losartan da inhibitors na isoenzyme CYP2C9 ba a yi nazari ba,
triamteren, spironolactone, amiloride da sauran diuretics na potassium, karin mai dauke da sinadarin potassium ko salts: ana iya lura da karuwar taro na potassium,
Shirye-shiryen lithium: raguwa a cikin fitowar lithium mai yiwuwa ne, sanya ido kan matakin lithium a cikin jini ya zama dole,
magungunan rigakafin rashin kula da steroidal (NSAIDs), ciki har da masu hana cyclooxygenase-2 inhibitors (COX-2): yana yiwuwa a raunana tasirin antihypertensive na losartan a cikin tsofaffi marassa lafiya ko marasa lafiya da rashin ruwa, daga ciki har da masu karbar diuretics, tare da wannan haɗin, mai sauyawa mai lalacewa cikin ayyukan renal yana yiwuwa , gami da faruwar cutar rashin girman koda, hadewar kwayoyi na buƙatar kulawa ta musamman,
katsewa sau biyu na RAAS (amfani da lokaci ɗaya na maganin ARA II da inhibitors na ACE ko renin inhibitor - aliskiren): haɗarin jijiyoyin jini, hyperkalemia, syncope da aiki mara nauyi (ciki har da gazawar ƙirar koda) yana ƙaruwa idan aka kwatanta da monotherapy, saka idanu na yau da kullun na aikin koda, hawan jini da taro na electrolytes a cikin jini.

Matsalolinda za a iya samu na ma'amala da amlodipine tare da amfani da lokaci daya tare da sauran abubuwan magunguna / wakilai:

digoxin, phenytoin, warfarin, indomethacin: babu wani tasiri game da ɗaure waɗannan kwayoyi zuwa sunadaran plasma jini bisa ga binciken binciken vitro,
cimetidine, antacids wanda ya haɗa da magnesium ko hydro hydroide, ruwan innabi (240 ml): babu wani tasiri mai mahimmanci akan magunguna na amlodipine yayin amfani da kashi ɗaya na ƙarshen,
atorvastatin (a cikin kashi 80 na MG): babu wasu canje-canje masu mahimmanci a cikin ma'auni na magunguna na ma'aunin magani na atorvastatin tare da sake gudanar da aikin amlodipine a cikin kashi 10 na mg,
sildenafil (kashi daya na 100 MG): a kan asalin hauhawar jini, ba a shafa magunguna na amlodipine, tare da wannan haɗin, kowane ɗayan waɗannan abubuwan da kansa yana nuna tasirin antihypertensive,
tacrolimus: haɗarin ƙara yawan ƙwayar plasma yana ƙaruwa, matakin wannan abun a cikin plasma ya kamata a sanya ido sosai,
simvastatin (a kashi 80 na MG): idan aka haɗu da amlodipine a kashi 10 na mg, bayyanuwar simvastatin yana ƙaruwa da kashi 77%, kashi na yau da kullun na simvastatin tare da wannan haɗin bai kamata ya wuce 20 mg ba,
dantrolene (iv gudanarwa): haɗarin arrhythmia, rushewa, hyperkalemia da raguwar hauhawar zuciya;
cyclosporin: haɓakawa da haɗuwarsa mai yiwuwa ne, a cikin marasa lafiya bayan sake haɓakar koda, an lura da haɓaka Cmin na cyclosporin a cikin plasma da kusan 40%, lokacin da aka haɗa shi da Lozap AM, ana buƙatar kulawa da Cmin na cyclosporin,
warfarin: Babu karuwa a cikin lokacin prothrombin,
ethanol: ba a gano wani tasiri mai mahimmanci ba a kan magungunansa,
itraconazole, ketoconazole, ritonavir (masu hana karfi na CYP3A4 isoenzyme): ƙwaƙwalwar ƙwayar plasma na amlodipine na iya ƙaruwa, saka idanu na yau da kullun game da alamun cututtukan jijiyoyin jini da edema ana buƙata,
diltiazem (a kashi na 180 MG), erythromycin (inhibitors na CYP3A4 isoenzyme): lokacin da aka haɗa diltiazem tare da amlodipine a kashi na 5 MG, ana samun karuwar 1.6 a cikin AUC na ƙarshen idan an haɗa wannan haɗin ga tsofaffi marasa lafiya tare da hauhawar jini, lokacin da aka haɗu da erythromycin a cikin masu sa kai na lafiya babu wani tasiri mai mahimmanci a cikin AUC na amlodipine, duk da haka, a cikin tsofaffi, ana iya yin rikodin canji mai mahimmanci a cikin bayyaninsa,
clarithromycin (inhibitor na CYP3A4 isoenzyme): haɗarin rage hauhawar jini yana ƙaruwa, ana buƙatar kulawa da hankali akan likita,
rifampicin da aka lalata tare da wort na St John's (inducers na CYP3A4 isoenzyme): ba a yi tasirin tasiri kan halayen magunguna na amlodipine ba; an ba da shawarar don saka idanu akan hawan jini.

Analogs na Lozap AM sune Lortenza, Amzaar, Amozartan, Lozartan, Sardip, da dai sauransu.

Sunan kasa da kasa mai zaman kansa

Losartan shine sunan kasa da kasa don maganin.

Masu adawa da C09DB Angiotensin II a hade tare da BKK.

Lozap AM magani ne don rage karfin jini da sake dawo da CCC.

Saki siffofin da abun da ke ciki

Lozap kwaya ce a cikin kusan harsashi. Akwai nau'ikan saki daban-daban, dangane da maida hankali kan babban bangaren - 12.5, 50, 100 MG.

babban sinadaran aiki sune sinadarin losartan,
microcrystalline cellulose, sitaci, sodium stearate, ruwa, crospovidone, silicon dioxide.

Ana siyar da miyagun ƙwayoyi a cikin kwali na kwali na 3, 6 ko 9 blisters.

Ra'ayoyi akan Lozap AM

Nazarin game da Lozap AM galibi tabbatacce ne. Marasa lafiya sun lura da babban tasiri na miyagun ƙwayoyi idan aka kwatanta da Lozap, tunda Lozap AM ya ƙunshi abubuwa guda biyu masu aiki, an wajabta don amfani tare da mafi tsananin AH ko tare da ci gaba da jaraba ga Lozap. Magungunan, bisa ga sake dubawa, yana da tasirin gaske akan CVS kuma yana ba ka damar sarrafa isasshen jini.

Bayanin maganin

Lozap Am wakili ne mai haɗuwa wanda ya ƙunshi abubuwa biyu masu aiki, wanda ɗayan, gishiri na musamman na amlodipine shine camsylate, wanda ke da kwanciyar hankali mafi girma idan aka kwatanta da amlodipine wanda aka fi amfani dashi. Dangane da gwaji na asibiti da kuma sake dubawa masu inganci da yawa game da Lozap Am 5 + 100 MG, an gano cewa, ba kamar sauran magungunan antihypertensive ba, miyagun ƙwayoyi suna nuna tasirin antihypertensive mafi ƙarfi, yayin da tasirin sakamako a lokacin aikin jiyya ba shi da yawa. Kuna iya siyan Lozap Am a cikin kantin magani yayin gabatar da takardar sayen magani daga likitanka.

Tsarin saki, abun da aka shirya da shiryashi

Kamfanin magungunan Czech Zentiva ne ya samar da maganin a madadin kwamfutar hannu: Lozap Am 5 da 100 MG ko 5 + 50 MG, lambar farko tana nuna abun ciki na amlodipine camsylate, na biyu - potassium losartan. Allunan an cakuda a blisters na guda 10 ko kuma kwalban filastik na guda 300. Farashin Lozap Am na iya dogara da tattarawar abubuwa masu aiki da cibiyar sadarwar kantin magani inda aka sayi maganin.

Alamu don amfani

An wajabta maganin ga manya da yara daga shekaru 6 tare da cututtukan masu zuwa:

hauhawar jini (hawan jini),
rigakafin infarction na zuciya na zuciya,
arrhythmia, ischemia da sauran cututtukan cututtukan CVS,
hauhawar jini a cikin marasa lafiya da ciwon sukari mellitus.

An wajabta magunguna don hawan jini.
An wajabta maganin don hauhawar jini a cikin marasa lafiya da masu ciwon sukari mellitus.
An wajabta magunguna don rigakafin lalacewa ta hanyar lalata.

Tare da kulawa

Kuna iya ɗaukar miyagun ƙwayoyi a cikin ƙarancin allurai tare da waɗannan abubuwan:

bugun zuciya
hyperkalemia
ruwa rashin daidaituwa,
hypotension a cikin yara 'yan shekaru 6 da haihuwa.

Kuna iya ɗaukar miyagun ƙwayoyi a cikin ƙarancin allurai don gazawar zuciya.
Magungunan yana contraindicated yayin lactation.
Kuna iya ɗaukar miyagun ƙwayoyi a cikin ƙarancin allurai tare da jijiyoyin jini a cikin yara a ƙarƙashin shekaru 6.

Yadda ake ɗaukar Lozap AM

Allunan ana daukarsu baka, ko da kuwa abincin ci. Matsakaicin kashi shine 50 MG kowace rana. An daidaita shi gwargwadon halayen mutum na haƙuri. A cikin cututtukan zuciya na zuciya, kashi na farko shine 12.5 MG. Idan babu tasirin sakamako, yana ƙaruwa zuwa 50 MG don cimma sakamako mafi girma.

Don rigakafin cututtukan zuciya na sakandare, ana daukar 50 mg sau ɗaya a rana. Farjin yana gudana kamar yadda likitan zuciya ya umurce shi.

Shan maganin don ciwon sukari

Ba za ku iya ɗaukar cikakken awo ba a karo na farko. Wajibi ne don bincika amsawar jikin, don haka an ba da shawarar fara tare da 50 MG kowace rana. Tare da ƙarin magani, kashi yana ƙaruwa zuwa 100 MG kowace rana. Zaka iya amfani da maganin nan take 100 MG ko 50 MG cikin saiti 2.

A cikin ciwon sukari na mellitus, cikakken kashi bai kamata a sha shi ba a karo na farko.

Hematopoietic gabobin

Sakamakon cin abinci mara kyau, wuce haddi ko rashi na baƙin ƙarfe, lithium, da bitamin na iya faruwa. Saboda wannan, yawancin cututtuka sun tashi - anemia, leukocytosis, da dai sauransu.

Sakamakon cin abinci mara kyau, wuce haddi ko rashi na baƙin ƙarfe, lithium, da bitamin na iya faruwa.

Wanne rukuni na kwayoyi ya ƙunsa?

Da farko kuna buƙatar gano wane rukuni na kwayoyi Lozap nasa ne. Kwayoyin don rage karfin jini suna cikin rukunin magungunan antihypertensive.

Umarnin don amfani ya ce suna shafan jiki ta hanyar hana haɗin angiotensin 2 tare da masu karɓar angiotensin. Saboda wannan, daidaituwar hawan jini yakan faru.

Daga ina waɗannan kwayoyin suke?

Alamun da ke cikin umarnin yin amfani da allunan Lozap, daga abin da suke taimakawa, sune kamar haka:

pathologically high matsa lamba,
rashin lafiyar zuciya na kullum - an hada da maganin a cikin jiyya gabaɗaya kuma ana buƙatar amfani da shi don marasa lafiya tare da rashin haƙuri ga ƙungiyar inhibitor ACE, kazalika saboda rashin sakamako,
rage hadarin bayyanuwar ko rikitarwa na zuciya da jijiyoyin bugun jini a cikin mutane tare da hauhawar jini da haguwar ventricular hagu,
nephropathy a cikin masu ciwon sukari da mutane tare da hauhawar jini.

Wani muhimmin halayyar ƙwayar cuta shine ikon ƙara ƙarfin juriya ga motsa jiki. Hana hauhawar cututtukan zuciya wani lamari ne mai amfani na allunan Allunan. Umarnin don amfani ya ƙunshi bayanin kashi don kowane Pathology.

Idan ka bi umarnin don amfani dashi a magani kuma ka san daidai yadda zaka sha miyagun ƙwayoyi daga matsin lamba, to ana samun sakamako na rage ƙarfin matsin lamba 5-6 bayan gudanarwa, to har yanzu ana ci gaba har kwana ɗaya. Tare da yin amfani da Allunan, akai-akai, an sami sakamako mai daidaituwa bayan wata daya bayan amfani da Allunan Allunan.

Tare da bayyana furotin, ƙwayar tana taimakawa wajen dakatar da asarar furotin.

Daga gefen metabolism

Rashin daidaituwa a cikin metabolism yawanci yakan faru yayin shan Lozap da wasu kwayoyi waɗanda basu dace da losartan ba.

Rashin lafiyar rashin lafiyar yana yiwuwa tare da yawan abin sama da ya wuce ko rashin haƙuri ga abubuwan da aka haɗa. An bayyana ta da gudawa, itching, redness na fata. A cikin halayen da ba a san su ba, yin narkewa ko tari na iya faruwa.

Abun dacewa

Lokacin amfani da maganin, an haramta shi sosai don shan giya, saboda losartan ya saba da barasa na ethyl.

Lokacin amfani da maganin, an haramta shi sosai don shan giya.

Yi amfani da lokacin daukar ciki da lactation

An haramta amfani da miyagun ƙwayoyi a farkon watanni uku da na uku, saboda akwai haɗarin haɓaka ƙarancin jiki. A lokacin HBV, ba a ba da shawarar amfani da magungunan antihypertensive, don kada a cutar da yaron. Binciken ya nuna cewa losartan na iya haifar da daskarewa na tayin.

Wani matsin ne zan sha?

Alamar matsin lamba don haɓakar hauhawar jini ga kowane mutum yana da likita. Sai kawai ya yanke shawara akan alƙawarin da kuma sokewa. Haramun ne a gudanar da magani tare da Lozap. Umarnin don amfani bai faɗi wane irin ƙarfi ake bada shawarar ba, don haka ya kamata a danƙa wa likitan kwararru.

Iri hauhawar jini

Yadda za a ɗauka?

Allunan Lozap don matsin lamba daidai da umarnin amfani da shi ana nuna su sha sau ɗaya a rana, farawa daga jiyya tare da ƙananan allurai. Kafin fara maganin ƙwayar cuta, ana yin gyaran ma'aunin ruwa-electrolyte. Dangane da umarnin haɓakar cirrhosis, ƙananan allurai ne kaɗai aka karɓa.

Hakanan, yawan ƙwayar potassium yana ƙaruwa a cikin tsofaffi, don haka a gare su, bisa ga umarnin, an kuma kafa amfani da mafi ƙarancin allurai.

Magungunan ba su tasiri da ikon sarrafa sufuri da maida hankali - an nuna wannan halayyar a cikin umarnin don amfani. Allunan ya kamata a bugu tare da babban adadin ruwa don kar a sami sakamako masu illa a cikin aikin hanji. Shin zai yiwu a sha Lozap a matsanancin matsin lamba - ba haka ba ne, saboda bisa ga umarnin don amfani, an yi niyya ne ga mutanen da ke da hauhawar jini don rage hawan jini.

Kafin ko bayan abinci?

Lokacin da aka tambayi yadda ake shan Lozap kafin ko bayan abincin, likitocin sun amsa cewa babu wani bambanci na asali, tunda dangane da umarnin don amfani, ana ɗaukar maganin ta baka, ba tare da la'akari da lokacin cin abinci ba.

Likitoci sun fayyace cewa lokacin da aka yi tambaya lokacin amfani da Lozap, menene magunguna a can, ana iya bambance lokuta da yawa dangane da umarnin likita:

Lokacin da aka gano shi tare da hauhawar jini, ana iya yin amfani da Lozap sau da yawa, sashi a kowace rana shine 50 MG bisa ga umarnin. Wani lokaci, don babban tasiri, ana ninka kashi biyu, amma kuma ana ɗaukar shi sau 1.
Ga mutanen da ke fama da rauni na zuciya, kashi shine 12.5 MG sau ɗaya a rana. Yana ƙaruwa kowane mako zuwa matsakaicin 50 MG. Dole ne a yarda da haƙuri da magunguna da contraindications bisa ga umarnin.
Ga marasa lafiya da ke cikin jiyya tare da manyan allurai na diuretics, an rage yawan ci zuwa 25 MG kowace rana.
A cikin tsofaffi, da farko likita bai daidaita daidaitaccen kashi na 50 MG kowace rana.
Lokacin da aka nuna amfani da maganin don rage haɗarin bayyanuwar cututtukan zuciya da hana mutuwa a cikin mutanen da ke fama da hauhawar jini, to bisa ga umarnin, kashi na farko shine 50 MG kowace rana. A tsawon lokaci, yana ƙaruwa zuwa 100 MG.
Ga marasa lafiya da ciwon sukari mellitus da proteinuria, matakin farko shine 50 MG kowace rana, sannu a hankali yana ƙaruwa zuwa 100 MG. Amma likita dole ne yayi la'akari da alamun alamun jini.
A gaban cututtukan hanta masu rikitarwa ko lokacin bushewar fata bayan hemodialysis akan kayan aiki, bayan shekaru 75, dole ne ka fara ragewa zuwa 25 MG kowace rana.

Duk magunguna da rubutattun magunguna za a iya samu a umarnin don amfani.

Har yaushe zan iya ɗaukar lokaci?

Lokacin da suke rubuta magani, nan da nan marasa lafiya suna tambayar tsawon lokacin da za a iya ɗaukar Lozap. Bayan zaɓin maganin da ya dace, amfaninsa yana ɗaukar watanni da yawa har ma da yawa shekaru. Duk ya dogara da ingancinsa.

Idan babu sakamako masu illa, matsin lamba ya sami ƙarfi sosai, to, bai kamata ku canza kayan aikin ba. Rashin magani ne kawai za'a iya yi akan shawarar likita. Lokacin da aka soke maganin, ƙara yawan matsa lamba zai iya faruwa. Ainihin lokacin daukar Lozap akan lokaci likita ne ya ƙaddara shi.

Daidaitawa

Ka'idodin sakamako masu illa waɗanda aka bayyana a cikin umarnin don amfani da sauri wuce tare da ci gaba da aikin sun haɗa da:

ciwon ciki
jin zafi a yankin kirji,
gajiya da sauri
kadan kumburi kafafu da hannu,
zawo
bugun zuciya
tashin zuciya
ciwon kai
cramps a cikin maraƙin ƙwayoyin maraƙi
tashin hankali na bacci
tari
hanci

Tare da amfani da tsawan lokaci

Sakamakon sakamako na Lozap tare da amfani da tsawan lokaci na iya shafar gabobin da tsarin daban-daban, tunda tara kayan kwayoyi a cikin jiki ke faruwa a hankali. Suna tsokani masu keta haddin:

asarar gashi har zuwa asari saboda yawan ƙwayar fata da ƙwaƙƙwarar fata,
rashin lafiyan a cikin yankunan da m fata,
Aiki a cikin aiki na jijiyoyin jini - ciwon zuciya, hanci,
take hakkin ayyuka na gastrointestinal fili: ƙonewa, maƙarƙashiya da zawo, ci abinci mai rauni,
tabarbarewa a cikin wari da dandano buds,
jihohi na yawan damuwa
urination akai-akai.

Mai jituwa da amfani na yau da kullun

A lokacin shan maganin, mai haƙuri ya kamata ya lura da abin da kwayoyi ya sha a bugu, ba da karfinsu, ya fi kyau a duba umarnin don amfani. Hakanan, ra'ayoyi masu sabani ana haifar dasu ta hanyar shan giya a lokacin amfani da wannan magani.

Shin yana yiwuwa a dauki Lozap tare da barasa - mutane suna yawan sha'awar. Wasu marasa lafiya sun yi imanin cewa barasa ba zai zama mai cutarwa ba yayin jiyya da kuma daidaituwa na al'ada na Lozap da barasa.

Nazarin waɗanda suka ɗanɗana irin wannan tasirin akan kansu suna nuna akasin haka. Bayan haka, sakamakon maganin yana tsawan kwana ɗaya daga lokacin gudanarwa, kuma don tasirin aikin ana aiwatar da shi cikin dogon lokaci. A wannan batun, Lozap da barasa ba su da jituwa.

Bisoprolol

Bisoprolol da Lozap - an yarda da jituwa tsakanin miyagun ƙwayoyi. Wadannan kwayoyi sun kasance daga rukuni na magunguna daban-daban. Dangane da umarnin don amfani, Bisoprolol shine adrenergic block, wanda yafi kulawa da ƙimar zuciya, rage shi.

Lozap - rage karfin jini. Tare, waɗannan magunguna suna da tasiri a cikin karuwar jijiyoyin jini a cikin matsa lamba tare da tachycardia, arrhythmia, da rauni na zuciya.

Wannan sanannen magani ne wanda aka yi amfani da shi bisa ga umarnin kulawa da hauhawar jini, tare da ƙirƙirar edema mai ƙarfi saboda rashin zuciya ko ga wasu dalilai. Wannan diuretic ne wanda, lokacin da hauhawar jini, yake aiki a matsayin vasodilator. Tambayar ta taso: shin zai yuwu a ɗauka Lozap da Indapamide tare?

Kapoten da Lozap - dacewar su na da matukar rikitarwa, kodayake ba za a iya cewa ba su da jituwa.

A wasu halaye, ana iya tsara mai karɓar mai karɓar angiotensin tare da angiotensin da ke canza magungunan inzyme inhibitory, wanda ke ba da damar mafi kyawun sakamako. Koyaya, a aikace, da wuya likitoci suka ba da izinin magani lokaci guda tare da waɗannan kwayoyi.

Eprosartan

Ana iya ɗaukar Eprosartan sau ɗaya ko kuma ya ba da umarnin ta hanya. Tare da amfani guda, matsa lamba yana daidaitawa kuma ya kasance al'ada a cikin kullun. Za'a iya samun tabbataccen sakamako na warkewa kawai bayan weeksan makonni na amfanin yau da kullun.

Eprosartan da Lozap suna da irin wannan sakamako, amma abubuwan daban-daban ne. A wannan batun, tambayar ta taso ko yana yiwuwa a lokaci guda Eprosartan tare da Lozap. Ba kwa buƙatar yin wannan don kada ku sami sakamako biyu kuma kada ku tsokani sakamako masu illa, wanda, daidai da umarnin don amfani, waɗannan kudade kusan iri ɗaya ne.

Shaidar wadanda suka dauki wannan maganin

Kuna iya samun adadi mai yawa na tabbatacce na mutane game da miyagun ƙwayoyi. Yana iya rage karfin jiki, yana daidaita aikin zuciya da bacci, yana kawarda tsananin farin ciki. Marasa lafiya sun ce Lozap yana aiki da sauri, amma ba a lura da sakamako mai tsawo ba. Umarnin ya bayyana cewa sakamakon zai iya tsawan kwana guda, amma wani lokacin yakan dauki tsawon awanni 4. Amma idan kun rage kashi kuma basu dauki lokaci ba 1, amma kuma mafi yawan lokuta, to sakamakon kawai ya isa awa 24. Marasa lafiya lura cewa amfani da ƙananan kashi yana taimakawa rage haɗarin sakamako masu illa. Amma tare da wannan dabarar, sakamakon bayan shan kwayoyin ba zai shiga cikin minti 30 ba, amma cikin awanni 1.5.

Hakanan, marasa lafiya sun lura cewa shan Lozap ba shi da sauƙin dacewa saboda tasirin diuretic mai ƙarfi, daga gare ta akwai yawan buƙatun motsa jiki don urinate. An lura da wannan musamman ta hanyar masu aiki. Binciken ya kuma bayyana wasu lokuta na shaye fitsari da daddare bayan farawar, wanda yake da wuya a cire koda bayan an soke shi.

Magungunan suna da analogues masu yawa ko kuma irin kwayoyi masu kama da irin wannan tasiri, waɗannan sune analogues masu sauki na Lozap. Amma umarninsu suna da bambance-bambance, kuma likita ne kawai zai iya ƙayyade yadda za'a maye gurbin Lozap.

Idan ana kwatanta Lozartan da Lozap, abin da yafi kyau shine tambayar da akai akai.Dangane da umarnin don amfani, ana nuna magunguna biyu don gyaran hauhawar jini. Su masu adawa da karɓar angiotensin ne.

Lozap da Losartan iri ɗaya ne, tunda abu mai aiki yana ma'anar daidaituwa. Dukansu magungunan suna da tasiri iri ɗaya cikin hauhawar jini, amma wannan ba dalili ba ne don maye gurbin liyafar da juna. Likita ne kawai yakamata ya bada shawarwarin da suka dace.

Idan muna magana game da magunguna na Lozap ko Lorista, wanne daga cikinsu ne mafi kyau, babu wani bambanci mai mahimmanci. Sun bambanta kawai a masana'antun da farashi. Lozap ya fi araha, ragowar yana kama da umarnin da aka yi amfani da shi.

Kafin tantance Valsartan ko Lozap, wanda yafi kyau, ya kamata ku fahimci fa'idodin su. Amfanin Valsartan shine tsarin aikinsa mai aiki, akasarinsa an cire shi ta hanjin canji ne - kashi 83%, kuma kashi 13% daga kodan. A wannan yanayin, ana yin allurar sau da yawa ga cututtukan hanta da kodan, tunda ba ƙari ba yana ɗaukar waɗannan gabobin.

Dangane da umarnin don amfani, an yi maganin maganin don lalata tasoshin jini da jijiyoyin jini. Don haka yana daidaita da kuma matsa lamba. Don zaɓar Valsacor ko Lozap - wanda yafi kyau, kuna buƙatar sanin bambance-bambance tsakanin waɗannan kudaden: Valsacor kwatancen kai tsaye ne na Valsartan, wanda ke nufin yana aiki akan ƙa'ida ɗaya, ba tare da cutar hanta ba kuma kusan ba tare da cutar da kodan ba. Hakanan, sakamakonsa mai rauni shine raka'a da yawa.

Saboda farashin mafi girma na wannan samfurin, marasa lafiya suna sha'awar abin da ya fi Valz ko Lozap. Don haka, Valz magani ne mai hanawa, mai hana AT1 masu karɓar angiotensin II. Dangane da umarnin, ba shi da contraindications don hulɗa tare da wasu kwayoyi, an bincika tasirinsa mai banƙyama a cikin dalla-dalla, shan magani yana da tasirin gaske game da ci gaban cutar.

Magungunan rigakafi, ACE inhibitor. Lokacin amsa tambayar, wanne yafi kyau, Lozap ko Enalapril, kuna buƙatar bayyana cewa magani na biyu yana rage matsa lamba da sauri. Farashin Enalapril, ya yi akasin haka, ya fi araha. Amma ya kamata a ɗauka a zuciya cewa, kamar duk masu hana ACE, yakan haifar da tari a gefe.

Wannan magani ne na antihypertensive wanda, bisa ga umarnin, yana rage hawan jini ba tare da karuwa mai ƙarfi ba a cikin bugun zuciya. Duk da mafi girman farashin Enap, likitoci, lokacin da suke amsa tambayar wanne ya fi kyau, Enap ko Lozap, suna ba da shawarar farkon na farko don shiga.

Lisinopril

Wannan magani yana daga rukuni na masu hana ACE. Wanne ya fi kyau, Lozap ko Lisinopril, tambaya ce akai-akai a cikin marasa lafiya. Dukansu magunguna tare da hauhawar jini suna aiki iri ɗaya, amma bisa ga umarnin, tari yana zama sakamako na Lisinopril. Kudin kusan iri ɗaya ne.

Wannan magani ne mai ƙima, mai hanawa ACE, bisa ga umarnin, tsawon lokacin tasirin yana ci gaba har kwana ɗaya. Babban sinadarin Diroton shine lisinopril, kuma tasirin magungunan guda iri daya ne. Abin da ya sa, don fahimtar Diroton ko Lozap, wanda ya fi kyau, kuna buƙatar sanin cewa likitoci sun maye gurbin Diroton Lozap kawai tare da rashin haƙuri na lisinopril.

Prestarium

Don fahimtar wacce ta fi kyau - Lozap ko Prestarium, kuna buƙatar fahimtar bambance-bambancensu. Prestarium shine mai hana ACE, bisa ga umarnin da ake amfani dashi don nau'ikan hauhawar jini, don mummunan rikicewar jijiyoyin jini da zuciya, saboda yana rage matsa lamba lafiya. Farashinsa yayi ƙasa. Amma Lozap bashi da tasirin sakamako guda ɗaya na halayen ƙungiyar ACE - bushe tari.

Noliprel magani ne mai hade. A cikin tsarin sa nan da nan akwai abubuwa masu aiki guda 2 na perindopril da indapamide, wadanda ke shafar jiki a lokaci guda, saboda haka yana aiki sosai.

Ana lura da sakamako mai tasiri na asibiti bayan wata na amfani kuma baya tare da karuwa a cikin zuciya. Game da wannan, amsar tambayar wanne ya fi kyau - Lozap ko Noliprel a bayyane yake.

In faɗi don tabbatar da damuwa ko Lozap wanda ya fi kyau daga cikinsu zai gaza. An umurce su sau da yawa sha sau ɗaya a cikin hadaddun. Damuwa wani abu ne wanda yake rage karfin jini, amma kuma yana daidaita karfin zuciya. Dangane da umarnin, ana ɗaukar Lozap da safe, da kuma Concor - da yamma. Zaɓin takamaiman haɗin da likita ya zaɓa daidai da yanayin da halayen mutum na jikin mai haƙuri.

Equator magani ne mai haɓaka. Don amsa tambayar Equator ko Lozap - wanda ya fi kyau, ya kamata a lura da abubuwan: idan aka kwatanta da Equator, Lozap yana da ƙarancin contraindications bisa ga umarnin amfani.

Magungunan Lozap AM yana da tasiri mai ƙarfi, tun da ya ƙunshi abubuwa masu aiki guda 2: losartan potassium da amlodipine. Wannan kayan aiki ne mafi inganci kuma amfaninsa bisa ga umarnin an nuna shi a lokuta masu wahala lokacin da Lozap baya taimako ko ya rigaya ya zama mai shan maye.

Sharuɗɗan da yanayin ajiya

Lokacin adanar Lozap Am, ya zama dole a kula da zafin jiki na daki wanda bai wuce digiri 30 akan Celsius ba. Rayuwar shiryayye na miyagun ƙwayoyi shine watanni ashirin da huɗu, bayan wannan lokacin an haramta maganin don amfani kuma dole ne a zubar dashi. Kuna iya ba da izinin isar da Lozap Am a Moscow da yankin akan rukunin yanar gizon mu.

Aikace-aikacen aiki mara kyau

Sakamakon karatun likitancin, ya zama cewa sakamakon shan Lozap, gazawar renal na iya haɓaka, saboda haka, mutanen da ke fama da matsalar keɓaɓɓen aiki suna buƙatar yin amfani da mafi ƙarancin kashi sau ɗaya a rana. Idan ba'a lura dashi ba, yana yiwuwa a wargaza gabaran, wanda hakan zai haifar da juyawar koda.

Abubuwan haɗin gwiwa

An hana shi amfani da Lozap a hade tare da diuretics, waɗanda ke ba da gudummawa ga tarin potassium, misali tare da Amiloride, Spironolactone, saboda ana iya haifar da hyperkalemia.

Haramun ne a yi amfani da Lozap a hade tare da diuretics, wanda ke ba da gudummawa ga tarin potassium.

Haɗuwa yana buƙatar taka tsantsan

Tare da yin amfani da magungunan anti-mai kumburi guda daya tare da rukunin, tasirin lazartan na iya raguwa, saboda haka kawar da hauhawar jini zai zama mara ma'ana, kamar tare da magungunan kungiyar placebo (marasa magani).

Idan, saboda wasu dalilai, Lozap ba za a iya ɗauka ba, ana iya maye gurbin shi da kwayoyi masu kama da wannan:

tushen hydrochlorothiazitis - Angizar, Amlodipin, Amzaar, Gizaar, Lorista, Lozap da (magungunan Rasha),
dangane da candersartan - Kandekor, Kasark, Hizart-N,
Babban kayan aikin telmisartan shine Mikardisplyus, Telpres, Talmista.

Kafin amfani da analog, kuna buƙatar tuntuɓi ƙwararre. Ga tsofaffi marasa lafiya da rashin haƙuri, an maye gurbin Lozap tare da Amlodipine.

Amlodipine shine ɗayan analogues na miyagun ƙwayoyi Lozap AM.
Kasark yana ɗayan analogues na miyagun ƙwayoyi Lozap AM.
Mikardisplyus - ɗayan analogues na miyagun ƙwayoyi Lozap AM.

Likitocin zuciya

Svetlana Aleksandrovna, Phlebologist, Rostov-on-Don

Ina ba da shawara ga marasa lafiya da yawa su dauki Lozap, saboda yana tasiri CVS sosai kuma yana rage karfin jini, yana hana cututtuka da yawa. Dangane da bayanan asibiti, wannan shine ɗayan magunguna mafi kyau da hauhawar jini.

Sergey Dmitrievich, likitan zuciya, Irkutsk

Na wajabta wa marasa lafiya da yawa bayan tiyata don kula da matsin lamba na yau da kullun, don kawar da hare-hare daga hauhawar jini.

Shawara ga likitan kwalliyar AMMA Lozap AMC

Olga Vasilievna, 56 years old, Kurganinsk

Na kwashe fiye da shekaru 5 kenan Lozap. Ina da ciwon sukari na 2. Magungunan sun gamsu sosai, matsin lamba koyaushe al'ada ne, babu sakamako masu illa.

Ivan, mai shekara 72, Moscow

Aka tsara likitan zuciya don rigakafin ciwon zuciya, saboda ina da cututtukan jijiyoyin zuciya. Yayinda yake taimakawa, Ina jin ƙarancin shekaru 30.

Rashin ƙarancin analogues

Sau da yawa likitoci suna ba da maganin Lozap. Ana amfani da analogs da musanya ga miyagun ƙwayoyi idan har jaraba ce ga jiki.

Vazotens shine madadin kwamfutar hannu ta Lozap. Yana da ainihin ɓangarorin aiki ɗaya, da kuma jerin abubuwan nuni. Yin amfani da maganin yana contraindicated ga mata masu juna biyu da kuma a lokacin lactation, da yara a karkashin shekara 18.
Blocktran shine madadin Lozap da aka yi a Rasha. Yana da kayan aiki guda ɗaya, don haka yawanci ana wajabta yin amfani dashi maimakon Lozap don maganin rashin lafiyar zuciya da hauhawar jini.
Lozarel kwatanci ne na Lozap. Abunda yake aiki abu daya ne kuma daidai gwargwado ne. Sabili da haka, umarnin don amfani da magungunan ya zo daidai da jerin abubuwan da ke nuna alamun illa.

Me zai maye gurbin idan Lozap bai riƙe matsin lamba ba?

Yadda za a maye gurbin Lozap idan ba ta riƙe matsin lamba ba tambaya ce mai yawa yayin da magani ya daina cika ayyukanta. Kwararrun suna maye gurbin shi da wasu kwayoyi tare da alamomi iri ɗaya bisa ga umarnin amfani.

Wannan koyaushe yana faruwa saboda gaskiyar cewa hauhawar jini yana haɓaka koyaushe kuma magungunan ƙarshe ba su da tasiri. Akwai dabaru uku don magance wannan matsalar:

kashi karuwa
sadar da haɗin maganin, wato, ƙarin ƙarin magunguna,
sauya samfurin da aka yi amfani da shi.

An ba da jerin sunayensu a sama. Dangane da yanayin mutum na cutar a cikin haƙuri da umarnin don maganin, likita ya zaɓi dabarun magani kuma yana kulawa da tasirirsa a cikin wani yanayi na musamman.