Ethamsylate: umarnin don amfani

Ethamsylate wakili ne na hemostatic, wanda aka san shi da aikin angioprotective da kuma aikin yaduwa. Magungunan yana haɓaka haɓakar fararen fararen fararen fata da fitowar su daga ragowar ƙashi, yana daidaita zaman lafiyar ganuwar capillaries, saboda su zama ƙasa shiga. Yana da ikon haɓaka adon jikin farashi da hana kwayar cutar ta sinadlandin biosynthesis.

Amfani da Etamsylate yana haɓaka samuwar thrombus na farko kuma yana haɓaka jinkirin sa, a zahiri ba tare da cutar da sinadarin fibrinogen a cikin jini da lokacin prothrombin ba. Ba shi da kaddarorin hypercoagulant; amfani da allurai na warkewa baya tasiri samuwar ƙyallen jini.

Tare da gudanarwa na ciki (iv), kunna aikin hemostasis yana faruwa a cikin mintuna 5 zuwa 15 bayan allura, kuma an sami sakamako mafi girma bayan sa'o'i 1-2. Tsawan lokacin aikin shine awa 4-6.

Lokacin da aka shigar da allunan Ethamsylate, mafi girman tasirin ana rikodin shi bayan sa'o'i 2-4. Ingantaccen taro na abu mai aiki a cikin jini shine 0.05-0.02 mg / ml. An cire maganin a cikin fitsari (80%), a cikin ɗan ƙaramin abu tare da bile.

Bayan kammalawar, tasirin warkewa ya ɗauki kwanaki 5-8, a hankali yana rauni. Babban inganci da ƙananan adadin contraindications na miyagun ƙwayoyi suna ba da kyakkyawan ra'ayi game da Etamsilate ta likitoci.

Ba a sanya magunguna don maganin cututtukan ƙwayar cuta mai ƙosasshen ƙwayoyin cuta, da gudawa da ciki.

Tsari sashi:

Ethamsylate yana samuwa azaman mafita don allurar ciki da allura, a cikin alluna da allunan ga yara.

Alamu suna nuna Ethamsilate

Dangane da umarnin don amfani da Etamsylate, ana amfani da miyagun ƙwayoyi don maganin cututtukan daji kuma a cikin hadaddun hanyoyin kulawa don:

1. Tsayawa da hana haɓakar jinni daga asalin cutar malaria,
2. Ayyukan tiyata a cikin aikin otolaryngological (tonsillectomy, microsurgery ear and other),
3. Ophthalmic tiyata (cirewa, cataract, keratoplasty, antiglaucomatous surgery),
4. Ayyukan hakori (cire granulomas, cysts, hakar hakori),
5. Ayyukan Urological (prostatectomy),
6. Sauran, gami da cututtukan cututtukan ƙwayar cuta, musamman - a jikin gabobin da kyallen takarda da keɓaɓɓen hanyar zagayawar jini,
7. Kulawar gaggawa don cutar huhu da hanji,
8. Hemorrhagic diathesis.

Umarnin don amfani da Etamsylate - allunan da injections

Ana gudanar da injections na Ethamsilate a cikin jijiyoyin zuciya da intramuscularly, a cikin aikin ophthalmic - a cikin nau'i na ido saukad da retrobulbar.

Daidaitaccen sashi na tsofaffi:

A ciki, kashi ɗaya na Ethamsilate ga manya shine 0.25-0.5 g, bisa ga alamu, ana iya ƙara yawan zuwa 0.75 g, parenterally - 0.125-0.25 g, idan ya cancanta har zuwa 0.375 g.

Ayyukan tiyata - don rigakafin etamzilate ana gudanar dashi a cikin / a cikin ko a cikin 1 m 1 awa kafin a yi tiyata a cikin kashi na 2-4 ml (1-2 ampoules) ko a ciki Allunan 2-3 (0.25 g) sa'o'i 3 kafin a yi tiyata .
Idan ya cancanta, shigar da 2-4 ml na miyagun ƙwayoyi a yayin aikin.

Lokacin da akwai haɗarin zubar jini bayan jini, ana yin 4 to 6 ml (2-4 ampoules) kowace rana ko ana ba allunan Etamsylate 6 zuwa 8 kowace rana. An rarraba sashi a ko'ina har tsawon awanni 24.

Gaggawa: allurar kai tsaye a ciki / cikin ko intramuscularly, sannan kuma kowane awa 4-6 cikin / in, cikin / m ko a ciki. An bada shawarar allura.

A cikin maganin metro- da menorrhagia, umarnin don amfani da ethamzilate don haila yana ba da shawarar sashi na 0.5 g a baki ko 0.25 g parenterally (wucewa ta narkewa) bayan awa 6 na kwanaki 5-10.

Bayan dalilai na hanawa - 0.25 g a baki sau 4 a kowace rana ko 0.25 g parenterally sau 2 a kowace rana a lokacin basur (zubar jini) da biyu a cikin fewan hawan keke na ƙarshe.

A cikin ciwon sukari na myacroangiopathy, ana gudanar da injections na Ethamsylate a cikin mai har tsawon kwanaki 10-14 a cikin kashi guda na 0.25-0.5 g sau 3 a rana ko a cikin darussan na watanni 2-3 tare da sashi na allunan 1-2 sau 3 a rana.

Tare da diathesis na basur, tsarin kulawa yana ba da izinin gabatar da miyagun ƙwayoyi a cikin darussan 1.5 g kowace rana a tsaka-tsakin yau da kullun na kwanaki 5-14. A cikin mawuyacin yanayi, farawa yana farawa da gudanarwa na 0.25-0.5 g 1-2 sau a rana don kwanaki 3-8, sannan sannan da wajabta bakin.

A cikin lura da igiyar ciki na dysfunctional zubar jini, dole ne a dauki Ethamsylate a baki a 0.6 grams kowane 6 hours. Tsawan lokacin magani kusan kwanaki 10 ne. Sannan ana ba da izinin kiyayewa na 0.25 g sau 4 a rana kai tsaye yayin zub da jini (hawan keke 2 na ƙarshe). Ana gudanar da Parenteral 0.25 g sau 2 a rana.

A cikin maganin ophthalmology, ana gudanar da maganin ta subconjunctival ko retrobulbar - a kashi na 0.125 g (1 ml na maganin 12.5%).

Ga yara:

A yayin aiki prophylactically, ta bakin a cikin sashi na 10-12 mg / kg a cikin kashi biyu allurai don kwanaki 3-5.

Gaggawa yayin aiki - ethamzilate allura a cikin jijiyoyin hannu 8-10 mg / kg nauyin jiki.

Bayan tiyata, don rigakafin zubar jini - a ciki, a 8 mg / kg.

Tare da ciwo basur a cikin yara, ana wajabta Ethamsylate a cikin kashi ɗaya na 6-8 mg / kg a baki, sau 3 a rana. Tsawon lokacin magani shine 5-14 kwanaki, idan ya cancanta, ana maimaita karatun bayan kwana 7.

Ana amfani da miyagun ƙwayoyi a cikin yara fiye da shekaru 6. Kada ayi kwayar cutar a gaban haemoblastoses.

Likitan dabbobi:

Ana kuma amfani da Ethamsylate a cikin aikin dabbobi. Sashi don kuliyoyi shine 0.1 ml a kilogiram na nauyin dabba, sau 2 a rana (injections).

Contraindications Etamsylate

Abubuwan haɗin maganin suna da alaƙa da haɓakar thrombosis da yanayin haɗin gwiwa:

• Hypersensitivity ga abubuwan da ke cikin miyagun ƙwayoyi,
• Thrombosis, thromboembolism, ƙara yawan jini,
• M nau'i na porphyria,
• Hemoblastosis (lymphatic da myeloid leukemia, osteosarcoma) a cikin yara.

Yi taka tsantsan tare da zub da jini a bango na yawan zubar da jini.

Magunguna ba tare da sauran magunguna ba. Kada a haɗa a cikin sirinji iri ɗaya tare da sauran magunguna da abubuwa.

Side sakamako Etamzilat

• jin rashin jin daɗi ko konewa a yankin kirji,
• jin wani nauyi a cikin ramin ciki
• ciwon kai da farin ciki,
• saka alama a cikin na jijiyoyin jini cibiyar sadarwa a fuskar
• raguwa a cikin karfin jini na systolic,
• m ji na necrosis na fata (numbness), da samuwar "Goose kumburi" ko na al'ada, muffled soreness lokacin da taba.

Analogs na Etamsilat, jerin

Lokacin da kake neman canji, don Allah a lura cewa cikakken analog na Etamsilate kawai shine Dicinon. Sauran analogues akan tasirin jiki:

Duk wani maye gurbin Etamzilat tare da analogues ya kamata a yarda da likita! Yana da mahimmanci a fahimci cewa wannan koyarwar don amfani da allunan Etamsylate da allura ba ta shafi analogues kuma bai kamata a yi amfani da shi azaman jagora zuwa aiki ba tare da alƙawarin da kuma shawarar likita ba.

Yanayin ajiya
Store a cikin duhu wuri daga yara a zazzabi da bai wuce 25 ° C.

Aikin magunguna

Hemostatic, angioprotective wakili.

Yana aiki akan haɗin platelet na hemostasis. Yana karfafa samuwar platelets da kuma sakin platelets daga raunin kasusuwa, yana kara adadin su da kuma aikin jiki. Yana haɓaka ƙimar thrombus na farko, wanda na iya zama saboda matsakaici na haɓaka ƙwayoyin thromboplastin, kuma yana haɓaka dakatarwar thrombus. Yana da aikin antihyaluronidase, yana hana rarrabuwar mucopolysaccharides na bango na jijiyoyin jiki kuma yana kwantar da ascorbic acid, a sakamakon wanda juriya na maganin capillaries yana ƙaruwa, lalacewa da ɓarna na microvessels yana raguwa. Ba shi da tasirin hypercoagulant, baya tasiri matakin fibrinogen da lokacin prothrombin.

Ana lura da mafi girman tasirin lokacin magana da baki bayan sa'o'i 3. A cikin kewayon kashi na 1-10 mg / kg, tsananin tsananin aiki gwargwado ne ga kashi, ƙarin karuwa a kashi yana haifar da ƙari kaɗan zuwa tasiri. Bayan hanya, magani yana ci gaba har tsawon kwanaki 5-8, a hankali yana rauni.

Pharmacokinetics

Bayan gudanar da baki, an kusan tunawa da shi daga hancin gastrointestinal. Matsakaicin maida hankali a cikin jini an samu shi ne bayan sa'o'i 3-4. Babban maida hankali ga jini shine 0.05-0.02 mg / ml. Yana da rauni yana ɗayan abubuwan kariya da ƙwayoyin jini. An rarraba shi a cikin sassa daban-daban da kyallen takarda (ya danganta da matsayin ƙarfin jininsu). Kusan 72% na maganin da aka gudanar ana cire shi a cikin sa'o'i 24 na farko tare da fitsari a cikin yanayin da ba canzawa. Ethamsylate ya haye shingen mahaifa kuma ya shiga cikin nono.

Alamu don amfani

Yin rigakafi da iko da basur a cikin najasa da na cikin gida na abubuwa daban-daban, musamman idan zubar jini ya lalace ta hanyar lalacewar endothelial:

- rigakafin da jiyya ga zub da jini yayin aiki da kuma bayan tiyata a cikin otolaryngology, likitan mata, likitan mata, urology, likitan hakori, likitan ido da na tiyata,

- rigakafin da kuma kula da zubar jinni na cututtukan cututtukan daji daban-daban da na wurare daban-daban: hematuria, metrorrhagia, hypermenorrhea, hypermenorrhea a cikin mata tare da rigakafin cututtukan ƙwayoyin cuta na hanji, hancin hanci, zubar jini.

Sashi da gudanarwa

Aiwatar da ciki ba tare da la'akari da abincin ba.

Yayin ayyukan tiyata, an wajabta wa 0.5-0.75 g (Allunan Allunan) 3 awanni 3 kafin a yi tiyata, an tsara yaran da suka wuce shekaru 12 a cikin nauyin 1-12 mg / kg nauyin jiki (1 / 2-2 allunan) a rana a cikin allurai 1-2, tsakanin kwanaki 3-5 kafin a yi aikin tiyata.

Idan akwai haɗarin zub da jini bayan haihuwa, an wajabta wa manya 1-2 g (allunan 4-8), an tsara yaran da suka wuce shekaru 12 8 nauyin jiki / kg (allunan 1-2) a rana (a cikin allurai 2) a cikin ranar farko bayan aiki.

Idan akwai cutar diorrhais (thrombocytopathy, cutar ta Villeurbrand, cutar Wörlhoff), an wajabta wa tsofaffi 1,5 g karatun (allunan 6), yara da shekarunsu suka haura shekaru 12 ana sa musu nauyin 6 mg / kg na jiki a kowace rana a cikin allurai uku lokaci don 5-14 kwana. Za a iya maimaita hanya, idan ya cancanta, bayan kwana 7.

A cikin microbetiopathies masu ciwon sukari (retinopathies tare da basur), an wajabta wa manya manyan kwayoyi na 0.25-0.5 g (allunan 1-2) sau 3 a rana don watanni 2-3, yara sama da shekara 12 - 0.25 g (1 kwamfutar hannu 1 ) Sau 3 a rana don watanni 2-3.

A cikin lura da metro da menorrhagia, ana ba da 0.75-1 g (Allunan Allunan) 3-4 a kowace rana a cikin allurai 2-3, suna farawa daga ranar 5th na haila zuwa ranar 5 ga watan gobe na gaba. Babu wata shaida game da buƙatar daidaita tsarin magunguna a cikin mutanen da ke fama da hanta da aikin koda.

Side sakamako

Daga tsarin mai juyayi: da wuya - ciwon kai, dizziness, flushing, paresthesia a cikin kafafu.

Daga narkewa kamar jijiyoyi: tashin zuciya, amai, gudawa, ciwon ciki.

Daga tsarin numfashi: bronchospasm.

A ɓangare na tsarin rigakafi: da wuya - halayen rashin lafiyan, zazzabi, fatar jiki, an bayyana yanayin cutar ta angioedema.

Daga tsarin endocrine: da wuya - sai ya ɓaci da ɓarna.

Daga tsarin musculoskeletal: da wuya - ciwon baya.

Dukkanin sakamako masu illa suna da sauƙin kai da ɓoyewa.

A cikin yara da aka bi da etamsylate don hana zub da jini a cikin lymphatic m da myeloid cutar sankarar bargo, mafi yawan lokuta ana lura da leukopenia.