Lisiprex - (Lisiprex)

Lysiprex magani ne wanda aka shirya don magance cututtukan zuciya da na jijiyoyin jini. Bayar da tsananin yanayin shari'ar, ana amfani dashi a hade tare da wasu magunguna ko azaman kayan aiki mai zaman kanta. Domin tsarin zuciya da jijiyoyin jini suyi aiki na yau da kullun a cikin cututtukan cututtukan fata, an wajabta magunguna don gudanar da ayyukan prophylactic.

Aikin magunguna

An haɗa magungunan a cikin rukuni na masu hana ACE. Lisinopril yana rage aikin ACE (enzyme angiotensin-mai canzawa). Sakamakon wannan, ragin lalacewa na angiotensin na nau'in farko zuwa na biyu, wanda ke da tasirin vasoconstrictive mai ƙarfi kuma yana haɓaka samar da aldosterone ta adrtal cortex, yana raguwa.

Magungunan yana rage matsin lamba a cikin ƙananan jijiyoyin jini na huhu, yana ƙaruwa juriya daga girman zuciya. Yana daidaita yanayin endothelium na glomerular, ayyukan da suke da ƙaranci a cikin marasa lafiya tare da hyperglycemia.

Abubuwan da ke aiki suna faɗaɗa bangon art fiye da rinjayar gado mai ɗaci. Tare da tsawaita amfani da miyagun ƙwayoyi, hauhawar jini na rage jini. Kayan aiki na iya rage raguwar cututtukan zuciya na hagu, inganta yanayin mutanen da suka sami rauni a zuciya.

Pharmacokinetics

Shan maganin ba shi da nasaba da abinci. Tsarin ɗaukar ciki yana zuwa kashi 30% na abubuwan da ake aiki da su. Bioavailability shine 29%. Haɗin zuwa sunadarai na jini ƙanƙane. Ba tare da canzawa ba, babban abu da kayan taimako suna shiga cikin jini.

Ana lura da mafi girman hankali a cikin plasma a cikin awanni 6. Kusan ba sa hannu a cikin tsarin metabolic. An cire ta ta juya daga cikin kodan tare da fitsari. Maƙƙarfan rabin rai yana ɗaukar awoyi 12.5.

Me aka wajabta masa?

Alamu don amfanin lysiprex:

• mai mahimmanci da sake jujjuyawar yanayin jijiya na jini,
• mai ciwon sukari nephropathy,
• na kullum zuciya
• m rashin ƙarfi infarction.

A cikin mummunan bugun zuciya, yakamata a sha magani a rana ta farko bayan harin don hana daskararwar bugun zuciya na hagu.

Contraindications

Asibitocin asibiti wanda ke iyakance gudanarwar Lysiprex:

• hypersensitivity ga mutum aka gyara na miyagun ƙwayoyi,
• gaban Quincke edema a cikin tarihin dangi,
• kwayoyin halitta don irin wannan amsawar kamar su angioedema.

An ba da damar yin amfani da contraindications, a gaban wanda aka yarda da amfani da Lysiprex, amma a hankali kuma tare da kula da yanayin haƙuri, ana la'akari da su:

• mitral stenosis, aortic, artal na yara,

• ischemia na zuciya
• ci gaban jijiya,
• matsanancin cutar na koda,
• gaban wani taro taro na potassium a cikin jiki,
• cututtukan nama na autoimmune.

Haramun ne a yi amfani da magani wajen warkar da cututtukan zuciya a cikin marasa lafiya wadanda ke wakilan launin fata.

Yadda ake ɗaukar lisiprex?

Ana ɗaukar allunan duka ba tare da tauna ba, komai abincin. Matsakaicin shawarar sashi shine 20 MG kowace rana, matsakaicin izini na yau da kullun shine 40 MG. Ana kirga tsawon lokacin da aka yi amfani da shi akayi daban-daban, gwargwadon tsananin cutar da tsananin alamun. Tasirin warkewar shan magani yana bayyana bayan kwanaki 14-30.

Sashi don monotherapy na cututtukan zuciya na kullum: kashi na farko - 2.5 MG kowace rana. Don kwanaki 3-5, ƙaruwa zuwa 5-10 MG kowace rana yana yiwuwa. Matsakaicin da aka ba da izini shine 20 MG.

Magunguna bayan bugun zuciya a cikin awanni 24 na farko bayan faruwar: 5 MG, kowace rana ana maimaita kashi daya a sashi. Bayan kwanaki 2, kuna buƙatar shan 10 MG, washegari, ana maimaita sashi a ƙaddara na 10 MG. Hanyar warkewa na iya wucewa daga makonni huɗu zuwa shida.

Cutar mai fama da cutar sankara - har zuwa 10 MG a kowace rana, a yanayin saukan hoto mai tsananin zafi, ana iya karuwa da sashi zuwa izuwa kowace rana izuwa 20 MG.

Nau'i na saki, marufi da abun da ke ciki

Allunan fararen fata ne, zagaye, silin-silin, tare da bevel da daraja.

Fitowa: alli hydrogen phosphate anhydrous - 50 mg, mannitol - 20 mg, sitaci masara - 34.91 mg, talc - 3 mg, magnesium stearate - 1.2 mg.

10 inji mai kwakwalwa. - fakiti mai bakin ciki (3) - fakitoci na kwali.
30 inji mai kwakwalwa - gwangwani polymer (1) - fakitoci na kwali.

Alamar magunguna

Mahimmanci da hauhawar jini (a cikin tsarin monotherapy ko a hade tare da sauran magungunan antihypertensive).

Rashin bugun zuciya na zuciya (a zaman wani ɓangaren haɗuwa da jiyya).

Marancin raunin myocardial (a cikin sa'o'i 24 na farko tare da ma'aunin hemodynamic mai tsayayye don kula da waɗannan alamun da hana haɓakar ventricular hagu da bugun zuciya).

Nephropathy na ciwon sukari (don rage albuminuria a cikin marasa lafiya tare da mellitus na sukari mai dogaro da jini na al'ada da kuma a cikin marasa lafiya marasa lafiya marasa lafiyar insulin-insellus tare da hauhawar jini).

Side sakamako

Daga tsarin zuciya: jijiyoyin jini, jin zafi a bayan sternum mai yiwuwa ne.

Daga gefen tsarin juyayi na tsakiya: dizziness, ciwon kai, rauni na tsoka.

Daga tsarin narkewa: zawo, amai, amai.

Daga tsarin numfashi: bushe tari.

Daga tsarin hawan jini: agranulocytosis, raguwa a cikin haemoglobin da hematocrit (musamman tare da amfani da tsawan lokaci), a cikin sassan da aka kewaya - karuwa a ESR.

A wani bangare na ruwa-electrolyte metabolism: hyperkalemia.

Metabolism: karuwar creatinine, urea nitrogen (musamman a cikin marasa lafiya da cutar koda, ciwon sukari mellitus, hauhawar jini).

Allergic halayen: fatar fata, angioedema.

Sauran: a cikin sassan da aka keɓe - arthralgia.

Umarni na musamman

Bai kamata a yi amfani da Lisinopril ba a cikin marasa lafiya da kertic stenosis, bugun zuciya. Kada kayi amfani a cikin marasa lafiya masu rauni na myocardial infarction: tare da barazanar mummunar raunin hemodynamic wanda ya danganta da amfani da vasodilator, tare da aikin renal mai rauni.

Kafin da lokacin jiyya, ya kamata a kula da aikin koda.

Kafin fara magani tare da lisinopril, yana da mahimmanci don rama rashi na asarar ruwa da salma.

An yi amfani dasu tare da taka tsantsan na musamman a cikin marasa lafiya da ke fama da rauni na aikin koda, tare da cutar sankarar halifa, da kuma rauni na zuciya.

Yiwuwar haɓakar jijiyoyin jini yana ƙaruwa tare da asarar ruwa saboda rashin lafiyar diuretic, abinci tare da ƙuntatawa gishirin, tashin zuciya, da amai.

A cikin marasa lafiya da cututtukan zuciya na nakasa jini tare da al'ada ko rage karfin jini, lisinopril na iya haifar da matsanancin jijiya.

Yin amfani da maganin lisinopril na lokaci guda tare da daskararren abinci na potassium, kayan abinci don abinci da madadin gishirin da ke ɗauke da potassium ba da shawarar ba.

Tare da yin amfani da lisinopril na lokaci daya tare da shirye-shiryen lithium, ya kamata a saka idanu akan yawan lithium a cikin jini jini.

Hulɗa da ƙwayoyi

Tare da yin amfani da lokaci ɗaya tare da wakilai na antihypertensive, ƙarin tasiri antihypertensive yana yiwuwa.

Tare da yin amfani da lokaci ɗaya tare da diuretics-sparing potassium (spironolactone, triamteren, amiloride), shirye-shiryen potassium, abubuwan gishiri wanda ke dauke da potassium, haɗarin hyperkalemia yana ƙaruwa, musamman ma a cikin marasa lafiya da ke fama da rauni na aikin ƙirar.

Tare da yin amfani da inhibitors na ACE da NSAIDs a lokaci guda, haɗarin haɓakar lalata yara, ƙwararrun hyperkalemia ba wuya.

Tare da yin amfani da lokaci ɗaya tare da dipasiti na "madauki", thiazide diuretics, ana inganta tasirin antihypertensive. Abunda ya faru na matsanancin jijiya, musamman bayan shan kashin farko na diuretic, a fili yana faruwa ne sakamakon hypovolemia, wanda ke haifar da karuwa a jinkirin tasirin sakamako na lisinopril. Riskara hadarin lalacewa da aikin keɓaɓɓiyar aiki.

Tare da yin amfani da lokaci ɗaya tare da indomethacin, tasirin antihypertensive na lisinopril yana raguwa, a fili saboda hanawar aikin prostaglandin a ƙarƙashin tasirin NSAIDs (waɗanda aka yi imanin zasu taka rawa a haɓakar tasirin masu illa na masu hanawa na ACE).

Tare da yin amfani da insulin lokaci guda, wakilai na hypoglycemic, abubuwan da suka samo asali na sulfonylurea, hypoglycemia na iya haɓaka saboda haɓakar glucose.

Tare da yin amfani da lokaci guda tare da clozapine, yawan haɗuwa da clozapine a cikin jini yana ƙaruwa.

Tare da yin amfani da carbonate na lithium lokaci guda, maida hankali ga yawan lithium a cikin jijiyar jini yana ƙaruwa, tare da alamun alamun maye.

An bayyana shari'ar ci gaban hyperkalemia mai haƙuri tare da mellitus na ciwon sukari tare da amfani da lokaci guda tare da lovastatin.

An bayyana batun yanayin tashin hankali mai tsananin jijiya tare da amfani da lokaci guda tare da pergolide.

Tare da amfani da lokaci ɗaya tare da ethanol, ana inganta tasirin ethanol.

Alamu don amfani

Ya kamata a dauki Lysiprex idan yanayi ya kasance:

1. Hauhawar jijiyoyin jini - mai mahimmanci da kuma sake jujjuyawar jiki (duka biyu magani ne kuma a haɗe tare da wasu kwayoyi)
2. Ciwon zuciya mai rauni (a zaman wani bangare na hada magani)
3. Rana ta farko bayan tazarar myocardial infarction, sannan kuma daga baya a matsayin wani bangare na hadewar jiyya
4. Cutar amai da gudawa - don rage albuminuria

Hanyar aikace-aikace

An ba da shawarar shan Lysiprex da safe sau ɗaya a rana. Amfani da maganin bai dogara da cin abinci ba.

Marasa lafiya tare da hauhawar jini wanda ba ya shan wasu kwayoyi an wajabta su milligrams 5 na Lisiprex. Idan babu wani sakamako, ana kara adadin zuwa 5 milligrams a kowane kwana biyu zuwa uku, har sai sun kai milligrams 20-40 a rana.

Matsakaicin kulawa ta yau da kullun shine milligrams 20 na miyagun ƙwayoyi, kuma mafi girman shine 40. Cikakken sakamako yana faruwa ne bayan makonni biyu zuwa hudu na magani.

Ga mutanen da ke fama da rauni na zuciya, farawar magani shine milligramms 2.5 a rana. Bayan kwana uku zuwa biyar, an ba shi damar ƙara zuwa milligram 5-10. Matsakaicin adadin yau da kullun shine milligrams 20.

Idan mai haƙuri ya kamu da matsanancin ƙwayar myocardial infarction, to ya kamata a ba shi milligram 5 na Lysiprex yayin rana, da kuma wani milligram 5 na yini. A nan gaba, ya zama dole a dauki milligram na magani 10 bayan kwana biyu da kuma wani 10 bayan kwana daya. Ainihin jiyya na tsawon makonni shida.

Tare da ciwon sukari mai narkewa, ana bada shawara don shan miligram 10 na miyagun ƙwayoyi kowace rana. Idan ya cancanta, ana iya ƙara shi zuwa milligram 20.

Nau'i na saki, abun da ke ciki

Ana samun magungunan da ke sama a cikin wadannan siffofin:

Abun da Lysiprex ya ƙunshi irin waɗannan abubuwa:

• 5, 10 ko 20 na milligram na lisinopril a cikin nau'i na lisinopril dihydrate
• 40, 50 ko 100 milligram na ƙwayar hydrogen phosphate mai ƙona baƙin jini
• 15, 20 ko 40 milligrams na mannitol
• 34.91, 36.06 ko 69.83 milligram na masara sitaci
• 2.5, 3 ko 6 milligram na talcum foda
• 1, 1.2 ko 2.4 milligram na magnesium stearate.

Yin hulɗa tare da wasu kwayoyi

Lokacin amfani da Lysiprex, yana da buqatar yin la’akari da fasalulluka na hulɗarsa da sauran magunguna, waɗanda za a bayyana a ƙasa:

1. Haɗarin magungunan da aka bayyana tare da shirye-shiryen potassium, abubuwan daskarewa na potassium, maye gurbin gishiri, wanda ya haɗa da potassium, kazalika da cyclosporine, yana ƙaruwa da damar haɓaka hyperkalemia
2. Amfani da lysiprex na lokaci guda tare da diuretics, beta-blockers, jinkirin tashar alli, allurar rigakafi, magungunan maganin tricyclic da magungunan anti-hauhawar haɓaka sakamako na antihypertensive
3. Haɗuwa tare da shirye-shiryen lithium na iya haifar da ƙaruwa cikin tattarawar wannan abu a cikin jini
4. Haɗin haɗarin lysiprex tare da magungunan hypoglycemic yana haɓaka tasirin su kuma yana iya haifar da ci gaban hypoglycemia
5. Magungunan anti-inflammatory Nonsteroidal, estrogens, da adonergic agonists suna rage tasirin lisiprex. Bugu da ƙari, haɗuwa tare da nau'in magani na farko na iya haifar da lalacewa aiki na renal.
6. Amfani da lysiprex na lokaci daya tare da inhibitors na serotonin reuptake inhibitors na iya haifar da hyponatremia.
7. Haɗin maganin da aka bayyana tare da ethanol yana haɓaka sakamakon ƙarshen.
8. Haɗin lisiprex tare da procainamide, cytostatics da allopuripole na iya haifar da leukopenia
9. Indomethacin yana rage tasirin antihypertensive na lisiprex
10. Lokacin amfani da lysiprex tare da clozapine, maida hankali na ƙarshen a cikin jini yana ƙaruwa

Akwai kwayoyi da yawa waɗanda ba za a iya haɗasu tare da lysiprex ba. Wadannan sun hada da:

Side effects

Yin amfani da lysiprex na iya haifar da sakamako masu illa:

1. Jin zafi a cikin sternum
2. Pressurearfin matsi mai ƙarfi
3. Tachycardia
4. Bradycardia
5. Saukar jini na Myocardial
6. Symara bayyanar cututtuka na Rashin Ciwon zuciya
7. Takewa da hanyar atrioventricular
8. Dizziness
9. Ciwon kai
10. Paresthesia
11. Rashin ƙarfi
12. Cutar Asthenic
13. Cramps
14. Damuwa
15. Wahala
16. Agranulocytosis
17. Leukopenia
18. Neutropenia
19. HakanKamara
20. Cutar amai da gudawa
21. Bronchospasm
22. Rage numfashi
23. Cutar Ruwa
24. Ciwan huhu
25. Ciwon ciki
26. Jaundice
27. Ciwon mara
28. Dyspepsia
29. Canje-canje na Ku ɗanɗani
30. Bushewa daga cikin bakin mucosa
31. Karin gumi
32. Itching na fata
33. Urticaria
34. Alopecia
35. Photophobia
36. Oliguria
37. Anuria
38. Rashin koda
39. Proteinuria
40. Rashin Jima'i
41. Wuce haddi potassium
42. Rashin ƙwayar soda
43. Arthralgia
44. Myalgia
45. Vasculitis
46. Arthritis
47. Allergic halayen

Yawan abin sama da ya kamata

Yawancin lokaci, alamun cutar yawan ƙwayar cuta ta Lysiprex yana faruwa a kan kashi ɗaya na 50 grams na miyagun ƙwayoyi. An bayyana su kamar haka:

1. Bakin bushewa
2. Nan da nan sauke cikin matsin lamba
3. Rikewar mahaifa
4. Damuwa
5. Rashin Gaggawa
6. Maƙarƙashiya
7. Damuwa

Lokacin da irin waɗannan alamun suka bayyana, maganin tiyata ya zama dole, tunda babu takamaiman maganin rigakafi. An wanke mai haƙuri tare da ciki, an ba da enterosorbents da laxatives. Ana sarrafa maganin 0.9% sodium chloride a cikin jijiya.

Hakanan za'a iya yin maganin hemodialysis. Wajibi ne a kula da alamun daidaiton ruwa, gwargwadon karfin jini.

A lokacin daukar ciki

Ba a ba da izinin matan da suke tsammanin jariri su ɗauki Lysiprex. Idan ciki ya faru yayin magani tare da wannan magani, dole ne a daina shan shi da wuri-wuri.

Masana sun tabbatar da cewa yin amfani da wannan magani a cikin watanni na biyu da na uku yana da mummunar tasiri a tayin, wanda aka nuna a cikin rage karfin jini, haɓakar rashin lafiyar koda, ƙarancin kashi na hypoplasia, hyperkalemia, da mutuwar cikin ciki.

Game da farkon watanni uku na ciki, babu wani tabbacin mummunan sakamako na Lisiprex akan tayi. Amma ya kamata a tuna cewa wannan maganin yana iya shiga cikin mahaifa.

Sharuɗɗan da yanayin ajiya

Adana magungunan da aka bayyana a cikin busasshiyar wuri, kariya daga hasken rana kai tsaye kuma ba za'a iya kaiwa ga yara. Yanayin zafin jiki kada ya wuce digiri 25 na Celsius.

Rayuwar shiryayye na Lysiprex shine shekaru biyu.

Zuwa yau, Lysiprex ba a cikin magunguna na Tarayyar Rasha ba.

A halin yanzu, a cikin magunguna na Yukren, Lisiprex ba na siyarwa bane.

A cikin magunguna na zamani, akwai wasu ƙwayoyi da yawa waɗanda suke kama da aikinsu zuwa Lisiprex. Wadannan sun hada da wadannan kwayoyi:

Zuwa yau, kusan babu sake dubawa akan Lysiprex akan layi. Amma a ƙarshen labarin, zaku iya fahimtar ra'ayoyin mutanen da suka yi amfani da shi don magani.

Idan kun taɓa yin amfani da wannan magani, don Allah raba ra'ayin ku game da sauran masu karatu.

Daga gefen metabolism

Asedara yawan tattarawar creatinine. A cikin mutanen da ke fama da cutar koda da cututtukan cututtukan koda, ƙwayar urea na ƙaruwa.

Fashin fata, haɓakar angioedema.

Ba a son shi don sarrafa kayan aiki masu rikitarwa ga mutanen da ke fuskantar tsananin wahalar ciki da ciwon kai lokacin shan Lisiprex.

Yi amfani da lokacin daukar ciki da lactation

Akwai haɗarin mummunar illa ga tayin, musamman ma a cikin karo na biyu da na uku na lokacin haihuwa. Mace tana shan allunan Lysiprex bayan koyo game da juna biyu ya kamata ta daina shan maganin. Babu wata shaida game da yiwuwar abubuwan da ke tattare da maganin a cikin nono. Lokacin shayarwa, shan miyagun ƙwayoyi an haramta shi sosai saboda yuwuwar haɗari na mummunar tasiri ga jariri.