Allunan magungunan Amoxiclav

A abun da ke ciki Allunan 250 mg / 125 mg hade kayan aiki hade amoxicillin (nau'i na trihydrate) da acid na bakin ciki (foda gishiri na potassium). Allunan kuma suna dauke da abubuwan taimako: MCC sodium croscarmellose.

Allunan magungunan Amoxiclav 2X 625 mg da 1000 MG sun ƙunshi abubuwan aiki mai aiki amoxicillin da clavulanic acid, gami da ƙarin abubuwa: anhydrous colloidal silicon dioxide, ƙanshin, aspartame, baƙin ƙarfe baƙin ƙarfe, talc, mai ɗauke da hydrogenated castor oil, MCC silicate.

Hada da Allunan magunguna na Amoxiclav Quicktab 500 MG da 875 MG ya ƙunshi abubuwa masu aiki amoxicillin da clavulanic acid, kazalika da ƙarin abubuwan da aka haɗa: anhydrous colloidal silicon dioxide, dandano, aspartame, baƙin ƙarfe baƙin ƙarfe, talc, hydrogenated castor oil, MCC silicate.

Hada da foda daga abin da aka shirya dakatarwar shine AmoxiclavHar ila yau, ya ƙunshi amoxicillin da clavulanic acid, kuma kamar yadda aka haɗa abubuwa masu aiki sun haɗa da sodium citrate, MCC, sodium benzoate, mannitol, sacodrin sodium.

Hada da foda don shirye-shiryen jiko Amoxiclav iv ya ƙunshi amoxicillin da acid clavulanic.

Fom ɗin saki

Magungunan suna cikin nau'ikan allunan. Amoxiclav 250 MG / 125 MG - allunan da aka rufe, kunshin ya ƙunshi 15 inji mai kwakwalwa.

Amoxiclav 2X (500 MG / 125 MG, 875 mg / 125 mg) - Allunan, waɗanda aka sanyaya, na iya ƙunsar kwamfutoci 10 ko 14.

Amfanilav Quicktab (500 mg / 125 mg, 875 mg / 125 mg) ana samun su ta hanyar allunan da aka tarwatsa, a cikin kunshin - 10 irin allunan.

Hakanan, ana yin samfurin ta hanyar foda wanda shine abin dakatarwa; kwalban ya ƙunshi foda don shirye-shiryen 100 ml na samfurin.

Ana kuma samar da foda, wanda daga ciki ne ake samar da mafita, wanda ake sarrafa shi ta ciki. Kwal din ya ƙunshi 600 MG na magani (amoxicillin 500 mg, clavulanic acid 100 mg), kwalayen 1.2 g kuma ana samun su (amoxicillin 1000 mg, clavulanic acid 200 mg), 5 fl.

Aikin magunguna

Bayani yana ba da bayanin cewa maganin rigakafi Amoxiclav (INN Amoksiklav) wakili ne na fili. Ungiyoyin masu hana ƙwayoyin cuta: penicillins masu ɗaukar nauyin gani. Abun da ke tattare da maganin ya ƙunshi amoxicillin (penicillin Semi-roba) da kuma clavulanic acid (hib-lactamase inhibitor). Kasancewar acid na clavulanic a cikin shirye-shiryen yana tabbatar da juriya na amoxicillin zuwa ayyukan β-lactamases, wanda kwayoyin halitta ke samarwa.

Tsarin clavulanic acid yayi daidai da maganin beta-lactam, wannan sinadarin yana da tasirin ƙwayoyin cuta. Amoxiclav yana aiki a kan nau'ikan da ke nuna halin ko in kula na amoxicillin. Wannan jere ne gram tabbatacce ƙwayoyin cuta, aerobic gram-kwayoyin cuta, gram-tabbatacce kuma gram-korau anaerobes.

Pharmacokinetics da kuma kantin magunguna

Dangane da jagorar magungunan Vidal, bayan sarrafa bakin, dukkan abubuwan biyu suna cikin nutsuwa daga narkewar abinci, shan abubuwan da ake amfani da su bai shafe shi ba ta hanyar abinci, don haka ba matsala yadda ake shan shi kafin ko bayan abinci. Mafi girman hankali a ciki jini an lura da sa'a daya bayan an sha maganin. Dukkanin kayan aikin magungunan suna gudana cikin ruwa da kyallen takarda. Har ila yau, Amoxicillin yana shiga hanta, ƙwayar synovial, prostate, tonsils, mafitsara, ƙwayar tsoka, ƙwayar ciki, ɓarin zuciya.

Idan membranes na kwakwalwa bai cika wuta ba, dukkanin abubuwan biyu masu aiki basa shiga ta hanyar BBB. A lokaci guda, kayan aiki masu aiki sun ƙetare shinge na ƙwayar mahaifa, an gano abubuwan da ke cikin su a cikin madara. Suna ɗaure sunadarai na jini zuwa kaɗan.

A cikin jiki, amoxicillin yana ɗaukar ƙananan sashi metabolism, clavulanic acid yana metabolized sosai. An fitar dashi daga jiki ta hanjin kodan, abubuwa marasa mahimmanci na abubuwa masu aiki sune ke fitar da hanjin hanji da huhu. Rabin rayuwar amoxicillin da acid acid shine 1-1.5.

Alamu don amfani da Amoxiclav

An wajabta Amoxiclav don cututtukan cututtuka da na kumburi waɗanda ke haɓaka saboda tasirin ƙwayoyin cuta waɗanda ke kula da wannan magani. Alamun masu zuwa don amfanin wannan magani an ƙaddara:

• kamuwa da cuta na gabobin ENT, kazalika da cututtukan da ke kama da jijiyoyin jini na sama na ciki (otitis mediaciwon kumburin ciki, sinusitis, pharyngitiscutar kansa)
• urinary fili cututtuka (tare da cystitisa yi sujada da sauransu)
• cututtuka na ƙananan ƙwayar cuta na huhu (huhu, mashakom da na kullum)
• cututtukan mahaifa da wata cuta mai kamuwa da cuta,
• kamuwa da cuta da haɗin kasusuwa,
• cututtukan cututtuka na kyallen takarda mai taushi, fata (gami da sakamakon cizon),
• cututtukan biliary fili (cholangitis, cholecystitis),
• odontogenic cututtuka.

Abin da kuma zai taimaka wa Amoxiclav, ya kamata ka nemi ƙwararrun masani don ganawar mutum ɗaya.

Contraindications

Tabbatar da dalilin da yasa kwayoyin hana daukar ciki da sauran nau'ikan taimako na miyagun ƙwayoyi, yakamata yakamata ayi la'akari da abubuwanda suka kasance contraindications:

• cutar mononucleosis,
• cututtukan hanta na baya ko cututtukan cholestatic yayin ɗaukar clavulanic acid ko amoxicillin,
• cututtukan cututtukan ƙwayar cutar hanji,
• babban hankali ga ƙwayoyin rigakafi daga rukuni na cephalosporins, penicillins, da sauran ƙwayoyin maganin beta-lactam,
• babban hankali ga abubuwan da ke tattare da maganin.

An tsara shi a hankali ga mutanen da ke fama da gaɓar hanta, mutanen da ke fama da cututtukan koda.

Side effects

Lokacin ɗaukar wannan ƙwayar rigakafi, waɗannan sakamako masu illa na iya bayyana a cikin marasa lafiya:

• Tsarin narkewa: barna ciamai, tashin zuciya, zawo, a lokuta mafi wuya, bayyanar raunin ciki, lalatawar hanta mai yiwuwa ne, bayyananniyar cututtuka sune hepatitis, jaundice, pseudomembranous colitis.
• Tsarin ciwan kai: a lokuta mafi ƙarancin gaske, leukopenia na sake juyawa, thrombocytopenia, a cikin lokuta mafi wuya - eosinophilia, pancytopenia.
• Bayyanar bayyanar cututtuka: itchingerythematous kurji cututtukan mahaifa, a lokuta da dama - amafflactic rawar jikim erythema, kumburi, vasculitis rashin lafiyan, bayyanar guda ɗaya - ciwo na Stevens-Johnson, pustulosis, derfitis na exfoliative.
• Ayyukan tsarin mara amfani: tsananin farin ciki, ciwon kai, a lokuta mafi ƙaranci - tursasawa, jin damuwa, tashin hankali, rashin bacci.
• Tsarin Urinary: babbar murya, interstitial nephritis.
• A cikin lokuta masu wuya, superinfection na iya faruwa.

An lura cewa irin wannan magani, azaman doka, baya haifar da illa da lalacewa.

Umarnin don amfani da Amoxiclav (Hanyar da sashi na Amoxiclav don manya)

Ba a sanya maganin a cikin allunan don yara 'yan shekara 12 ba. Lokacin da ake rubuta magani, ya kamata a ɗauka a cikin zuciya cewa halatta kashi a kowace rana na clavulanic acid shine 600 MG (ga manya) da 10 MG a 1 kilogiram na nauyi (ga yaro). A halatta na yau da kullun na amoxicillin shine 6 g na manya da 45 MG a 1 kilogiram na nauyi na yaro.

Ana shirya shirye-shiryen parenteral ta hanyar rushe abinda ke cikin vial a cikin ruwa don allura. Don narke 600 MG na miyagun ƙwayoyi, kuna buƙatar moles 10 na ruwa, don narke 1.2 g na miyagun ƙwayoyi - 20 ml na ruwa. Dole ne a gudanar da maganin a hankali na minti 3-4. Ya kamata a ci gaba da jiko na ciki na mintuna 30-40. Kar a daskare mafita.

Kafin maganin sa barci don hana rikice-rikice na purulent, kuna buƙatar shigar da ciki 1,2 na kwayoyi. Idan akwai haɗarin rikitarwa, ana gudanar da maganin a cikin jijiya ko kuma a sarrafa ta a cikin maganin bayan tiyata. Tsawon lokacin izinin likita ne yake ƙaddara.

Allunan Amoxiclav, umarnin don amfani

A matsayinka na mai mulki, manya da yara (wanda nauyinsu ya wuce kilo 40) suna karɓar kwamfutar hannu 1 kowane awa takwas. (375 MG), an ba da cewa cutar ta kasance mai sauƙi ko matsakaici. Wani tsarin kulawa da yarda a wannan yanayin shine kwamfutar hannu 1 kowace kwamfutar ta 12 awanni 12. (500 MG + 125 MG). Don cututtukan da ke tattare da kamuwa da cuta, har ma da cututtukan da ke kama da na huhun hanji, ana nuna kwamfutar hannu 1 kowane awa takwas. (500 MG + 125 MG) ko sha a kowace awa 12 awa 1 kwamfutar hannu. (875 mg + 125 mg). Ya danganta da cutar, kuna buƙatar ɗaukar maganin rigakafi don kwanaki biyar zuwa kwanaki goma sha huɗu, amma dole ne likita ya tsara tsarin aikin magani da akayi daban-daban.

Ga marasa lafiya da kamuwa da cututtukan cututtuka na odontogenic, nuna magunguna kowane 8 hours, 1 kwamfutar hannu. (250 mg + 125 mg) ko sau 12 awanni, 1 kwamfutar hannu kowane. (500 MG + 125 MG) na kwana biyar.

Mutane masu matsakaici na gazawar, yana nuna liyafar 1 tebur. (500 MG + 125 MG) kowace sa'a goma sha biyu. Rashin girman na kiba shine dalilin kara tazara tsakanin allurai har zuwa awanni 24.

Dakatarwar Amoxiclav, umarnin don amfani

Shekarun yara na mai haƙuri ya tanadi ƙididdigar yawan shan la'akari da nauyin yaron. Kafin shirya syrup, ya kamata ku girgiza kwalban da kyau. A cikin allurai biyu, 86 ml na ruwa ya kamata a kara a cikin kwalbar, kowane lokaci kana buƙatar girgiza abin da ke ciki. Ya kamata a lura cewa cokali mai aunawa ya ƙunshi 5 ml na samfurin. Sanya cikin kashi gwargwadon shekarun yaro da nauyinsa.

Umarnin don amfani da Amoxiclav ga yara

Daga haihuwa zuwa watanni uku, an sanya wa yara magani a cikin nauyin 30 MG a cikin kilo 1 na nauyin (kashi ɗaya kowace rana), wannan kashi ya kamata a raba daidai kuma ana gudanar dashi a tsaka-tsakin kullun. Daga lokacin da ya cika watanni uku, an tsara Amoxiclav a ƙarancin 25 MG a 1 kilogiram na nauyi, an raba shi daidai biyu zuwa injections biyu. Game da cututtukan cututtukan cututtukan ƙwayar cuta na matsakaici, an tsara sashi a cikin nauyin 20 MG a 1 kilogiram na nauyi, ya kasu kashi uku. A cikin cututtukan cututtukan maɗaukaki, ana yin maganin gwargwadon nauyin 45 a kowace kilo 1 na nauyi, raba shi zuwa allurai biyu kowace rana.

Umarnin don amfani da Amoxiclav Quicktab

Kafin ɗauka, ya kamata a narke kwamfutar hannu a cikin ruwa na 100 ml na ruwa (adadin ruwan na iya zama ƙari). Dage abin da ke ciki sosai kafin amfani. Hakanan zaka iya tauna kwamfutar hannu, ya fi kyau amfani da miyagun ƙwayoyi kafin cin abinci. Manya da yara bayan sun kai shekaru 12 ya kamata su ɗauki kwamfutar hannu 1 a rana. 625 mg sau 2-3 a rana. A cikin cututtukan cututtukan da ke damuna, an tsara kwamfutar hannu 1 1000 mg sau 2 a rana. Jiyya kada ta wuce sati 2.

Wani lokacin likita na iya yin wasiƙun analogues na miyagun ƙwayoyi, alal misali, Flemoklav Solutab da sauransu.

Amoxiclav tare da angina

Magungunan Amoxiclav ciwon makogwaro An wajabta wa ɗan ƙaramin kwamfutar hannu 1 kwamfutar hannu. 325 MG sau ɗaya a kowace 8 hours. Wani tsarin kula da magani ya ƙunshi shan kwamfutar hannu 1 sau ɗaya a cikin kowane 12 hours. Likita na iya ba da magani mafi kyawun kwayar rigakafi idan cutar a cikin tsofaffi tayi tsanani. Kula da angina a cikin yara ya shafi amfani da fitarwa. A matsayinka na mai mulki, ana sanya cokali 1 cokali (cokali mai sau 5 ml ne). Mitar likitan likita yana ƙaddara ta, shawarwarin waɗannan suna da mahimmanci a bi. Yadda ake ɗaukar Amoxiclav a cikin yara masu fama da angina ya dogara da tsananin cutar.

Maganin Amoxiclav don sinusitis

Shin Amoxiclav yana taimakawa tare da sinusitis, ya dogara da dalilai da halayen cutar. Sashin likita yana ƙaddara maganin ne. An ba da shawarar ku sha Allunan kwayoyi 500 sau uku a rana. Kwanaki nawa za a sha magani ya dogara da tsananin cutar. Amma bayan bayyanar cututtuka sun ɓace, kuna buƙatar ɗaukar magani don wani kwanaki biyu.

Yawan damuwa

Don guji yawan shaye-shaye, an sanya allurar da aka tsara don yara da kuma yawan maganin Amoxiclav ga manya a bayyane. An ba da shawarar ku bincika umarnin a hankali ko kalli bidiyo kan yadda ake tsarke dakatarwar.

Wikipedia ya nuna cewa tare da yawan shan magunguna, da yawa alamu mara kyau na iya faruwa, amma babu bayanai game da yanayin barazanar rayuwa ga mai haƙuri. Yawan zubar da jini na iya faruwa. ciwon ciki, amai, zawofarin ciki. A cikin lokuta masu tsauri, raɗaɗi na iya faruwa.

Idan an dauki magani kwanan nan, ana yin layin na ciki, a nuna carbon kunnawa. Ya kamata likita ya kula da mara lafiyar. Inganci a waccan harka maganin hemodialysis.

Haɗa kai

Tare da gudanar da magani na lokaci daya tare da wasu kwayoyi, bayyanar da ba a buƙata na iya faruwa, wanda shine dalilin da ya sa bai kamata a yi amfani da allunan, syrup da sarrafawa na jijiya ba a layi ɗaya tare da kwayoyi da yawa.

Amfani da kwayoyi tare lokaci guda Glucosamine, antacids, aminoglycosides, magungunan laxative yana rage jinkirin shan ƙwayoyi na Amoxiclav, lokacin ɗauka tare Ascorbic acid - sha na hanzari.

Tare da lura na lokaci daya tare da phenylbutazone, diuretics, NSAIDs, Allopurinol da wasu kwayoyi waɗanda ke toshe ɓoyayyen tubular, karuwa a cikin taro na amoxicillin yana faruwa.

Idan an gudanar da aikin kulawa da magunguna na jiki da na lokaci tare da Amoxiclav, lokacin prothrombin yana ƙaruwa. Sabili da haka, wajibi ne don tsara kuɗi a cikin irin wannan haɗin a hankali.

Amoxiclav yana kara yawan guba Methotrexate yayin shan.

Lokacin ɗauka a lokaci guda Amoxiclav da Allopurinol da alama bayyanuwar exanthema yana ƙaruwa.

Bai kamata a ɗauka a lokaci guda ba Disulfiramda Amoxiclav.

Co-gwamnatin antagonists ne amoxicillin da Rifampicin. Magunguna suna iya raunana tasirin ƙwayoyin cuta.

Amoxiclav da ƙwayoyin cuta na bacteriostatic (tetracyclines, macrolides), da sulfonamides bai kamata a ɗauka a lokaci guda ba, tunda waɗannan magungunan na iya rage tasirin Amoxiclav.

Probenecid qara maida hankali ne da amoxicillin kuma yana rage jinkirin sa.

Lokacin amfani da Amoxiclav, tasirin tasirin maganin hana haifuwa na iya raguwa.

Umarni na musamman

Tun da yawancin mutane da ke fama da cutar sankara (lymphocytic leukemia) da kuma tare da mononucleosis na cuta da kuma wanda ya karɓi Ampicillin, daga baya an lura da bayyanuwar erythematous fashin, irin waɗannan mutane ba a ba da shawarar su ɗauki maganin rigakafi na ƙungiyar ampicillin ba.

Hankali an wajabta wa mutane masu dabi'ar rashin lafiyan mutum.

Idan an tsara hanyar magani tare da miyagun ƙwayoyi ga manya ko yara, yana da mahimmanci a kula da koda, hanta, da samuwar jini.

Mutanen da ke da rauni game da aiki na renal suna buƙatar daidaitawa ta kashi ko karuwa a tsakanin tazara tsakanin magunguna.

Zai fi kyau a sha magani lokacin cin abinci don rage yiwuwar sakamako masu illa daga tsarin narkewa.

A cikin marasa lafiya da ke cikin jiyya tare da Amoxiclav, za a iya lura da mummunan-tabbatacce a cikin aiwatar da ƙayyadaddun abubuwan glucose a cikin fitsari yayin amfani da mafita na Flis ko kuma reened na Benedict.

Babu bayanai game da mummunan tasirin Amoxiclav game da ikon tuki motoci da aiki tare da madaidaitan hanyoyin aiki.

Marasa lafiya waɗanda ke da sha'awar Amoxiclav ƙwayar rigakafi ce ko a'a, ya kamata a ɗauka a hankali cewa ƙwayar magungunan ƙwayar cuta ce.

Ana bada shawara don cinye ruwa da sauran magudanan ruwa yayin aikin tare da maganin.

Idan an ayyana Amoxiclav, dole ne a la'akari da shekarun yaro na haƙuri a cikin lokacin da yake tsara nau'ikan ƙwayoyi da sashi.

Analogs na Amoxiclav

Akwai da yawa analogues na wannan magani. Farashin analogues ya dogara, da farko, akan masana'antun magungunan. Akwai analogues akan siyar da mai rahusa fiye da Amoxiclav. Ga marasa lafiya da ke sha'awar abin da zai iya maye gurbin wannan ƙwayar cuta, kwararru suna ba da jerin manyan magunguna. Wannan yana nufin Moxiclav, Co-Amoxiclav, Augmentin, Clavocin, Flemoklav, Karafi, Baktoklav, Ranklav, Amovikombda sauransu .. Koda yake, kawai likita ne yakamata ya rubuta duk wanda zai maye gurbin. Kuna iya zaɓar analog mai rahusa a cikin allunan, alal misali, Augmentin. Hakanan zaka iya ɗaukar bayanan analog na Rasha, alal misali, Amoxicillin.

Wanne ya fi kyau: Amoxiclav ko Augmentin?

Menene abin da ke ciki na Amoxiclav da Augmentin, menene bambanci tsakanin waɗannan magungunan? Duk waɗannan kayan aikin suna ɗauke da kayan aiki masu aiki iri ɗaya, wannan shine, hakika, wannan abu ɗaya ne. Dangane da haka, tasirin magungunan magungunan kusan kusan iri ɗaya ne, kazalika sakamako masu illa. Masu masana'antar waɗannan magunguna ne kawai suka bambanta.

Amoxiclav yayin daukar ciki da lactation

Ammarlalav na ciki za'a iya amfani dashi idan tasirin da aka zata ya wuce cutar da tayi. Amfani da Amoxiclav a farkon matakan ciki ba a so. Fiye da 2 da watanni uku sun fi dacewa, amma har a wannan lokacin, ya kamata a lura da sigar Amoxiclav yayin daukar ciki sosai. Ammarlalav nono kar a rubuta, tunda abubuwanda ke amfani da maganin sun shiga cikin nono.

Nazarin Amoxiclav

A kan aiwatar da tattaunawa game da miyagun ƙwayoyi Amoxiclav, sake dubawa na likitoci da marasa lafiya galibi tabbatacce ne. An lura cewa maganin rigakafi yana da tasiri a cikin cututtukan cututtukan hanji, kuma ya dace da manya da yara. Binciken ya ambaci tasiri na miyagun ƙwayoyi don sinusitis, don kafofin watsa labarai na otitis, don kamuwa da cuta na ƙwayar cuta. A matsayinka na mai mulki, marasa lafiya na manya suna shan Allunan 875 MG + 125 MG, tare da madaidaicin sashi, sassauya yanayin yana zuwa da sauri. A cikin sake dubawa, an lura cewa bayan hanya na maganin rigakafi, yana da kyau a sha magungunan da ke dawo da al'ada microflora.

Binciken dakatarwar Amoxiclav shima tabbatacce ne. Iyaye sun rubuta cewa ya dace don ba da samfurin ga yara, tunda yana da dandano mai daɗi kuma yara ne ake gane shi.

Farashin Amoxiclav, inda zaka siya

Farashi Allunan kwayoyi na Amoxiclav 250 MG + 125 MG na jimlar 230 rubles don guda 15. Sayi maganin rigakafi 500 MG + 125 MG za'a iya yin farashi a 360 - 400 rubles don 15 inji mai kwakwalwa. Nawa ne kwayoyin hana daukar ciki MG 875 + 125 mgya dogara da wurin sayarwa. A matsakaici, farashin su shine 420 - 470 rubles don guda 14.

Farashi Amoxiclav Quicktab 625 mg - daga 420 rubles don guda 14 inji.

Farashin dakatarwa Amoxiclav ga yara - 290 rubles (100 ml).

Farashi Amoxiclav 1000 MG a cikin Ukraine (Kiev, Kharkov, da dai sauransu) - daga 200 hryvnias don guda 14.

Sashi da gudanarwa

An tsara allunan Amoxiclav ga marasa lafiya waɗanda shekarunsu suka wuce 12 kuma suna yin nauyi fiye da 40 kg.

Don cututtukan cututtuka masu laushi zuwa ga tsananin rauni an wajabta magani a cikin sashi:

• 250 mg + 125 mg (375 mg) sau 3 a rana,
• 500 mg + 125 mg (625 mg) sau 2 a rana.

A cikin kamuwa da cuta mai tsanani, kazalika da cututtukan numfashi, Amoxiclav a cikin allunan an wajabta su a cikin sashi:

• 500 mg + 125 mg (625 mg) sau 3 a rana,
• MG 875 + 125 mg (1000 mg) sau 2 a rana.

Mafi girman adadin yau da kullun na amoxicillin ga manya shine 6 g, clavulanic acid 600 mg.

Mafi girman matakan yau da kullun na amoxicillin ga yara shine 45 MG a kilogiram na nauyi, clavulanic acid 10 MG a kowace kg.

Tsawan lokacin jiyya na iya zama daga kwanaki 5 zuwa 14. Yaya lokacin da za a sha magani ya kamata likita ya yanke shawara.

Don cututtukan cututtukan ƙwayar cuta ta baki, Amoxiclav a cikin sashi na 375 mg an wajabta shi sau 3 a rana, a sashi na 625 MG - sau 2 a rana don kwanaki 5.

Idan mai haƙuri ya kamu da cutar koda tare da dunƙulewar ƙwaƙwalwar ƙwayar cuta mai nauyin 10 zuwa 30 a minti ɗaya, to, an tsara maganin a cikin sashi na 625 MG tare da tazara tsakanin sa'o'i 12, idan keɓantar da ƙarancin ƙarancin ƙira bai wuce 10 ml a minti ɗaya ba, to, an rage yawan lokacin sarrafawa zuwa 1 a kowace rana.

Idan babu fitsari, to amsar tsakanin ɗaukar kwaya ta gaba ya zama akalla kwanaki 2.

Side effects

Lokacin shan magani, waɗannan halayen da ba a buƙaci na iya bayyana, waɗanda aka bayyana kaɗan kuma sun ƙare bayan ƙarshen far:

• rashin ci, gudawa, tashin zuciya, amai, rashin aikin hanta,
• rashin lafiyan mutum
• ƙara yawan eosinophils, tsawan lokaci na prothrombin, rage dukkan ƙwayoyin jini,
• wuce kima aiki, damuwa, matsalolin bacci, damuna, tsananin damuwa, ciwon kai,
• Saline Diathesis, Cinema,
• superinfection, gami da murkushe hannu.

Kamar yadda abubuwa masu aiki, amoxicillin da clavulanic acid wani bangare ne na allunan:

Kamar yadda ƙarin abubuwan haɗin, abubuwan da ke cikin allunan sun haɗa da:

• silin silica,
• MCC
• foda talcum
• magnesium stearate,
• polyvinylpyrrolidone,
• croscarmellose sodium.

Abun da fim ɗin fim ya ƙunshi waɗannan abubuwan da aka haɗa:

• talcum foda:
• tagwaye 80,
• sabbinne,
• wannan ita ce manufa
• titanium oxide
• citethyl citrate.

Pharmacology da pharmacokinetics

Amfani da Amoxiclav yana da yawaitar ayyukan antimicrobial. Wadannan kananan kwayoyin suna da hankali ga kwayoyin cuta:

• Tawancik,
• Yersinia enterocolitis,
• sakkwatocin,
• farilla farida,
• E. coli
• Klebsiella
• gonococci
• meningococci,
• Shigella
• salmonella
• cutar gudawa,
• Kare
• bacteroids
• pertussis wand
• yaddumar magani
• fusobacteria,
• brucella
• campolobacter ayuni,
• Ducrey's Wand,
• mura wand
• Helicobacter pylori,
• moraxella cataralis,
• peptococci,
• kawancenpix,
• Clostridia
• preotella.

Bayan gudanar da baki, duka abubuwanda ke aiki suna hanzari cikin hanzari daga narkewa, ana lura da mafi girman lokacin bayan awa daya. Cin abinci baya tasiri shaƙar ƙwayoyi.

Kwayoyin rigakafi suna shiga cikin kasusuwa da ganyayyaki da yawa, suna ratsa cikin mahaifa kuma an kebe shi da kadan tare da madara.

An metabolized a cikin hanta, an cire shi musamman tare da kodan, rabin rayuwar ya bambanta daga 1 zuwa 1.5 hours.

A cikin cututtukan ƙwayar cuta mai narkewa, rabin rayuwar don amoxicillin yana ƙaruwa zuwa 7.5 hours, don clavulanic acid zuwa 4.5 hours.

Sharuɗɗan da yanayin ajiya

Ana iya siyar da magani tare da takardar sayen magani na likita. Ya kamata a adana magungunan a cikin busassun wuri inda yara ba zasu iya samun su ba, a ƙalla 25 мумСаксимумС.

(Ka bar bita a cikin bayanan)

* - Matsakaicin matsakaici tsakanin masu siyarwa da yawa a lokacin saiti ba tayin jama'a bane

Allunan Amoxiclav da foda - umarnin don amfani

Ga yara 'yan kasa da shekara 12 - 40 MG a kilo kilogram na nauyi kowace rana.
Ga yara waɗanda nauyinsu ya wuce 40 kilogiram, an tsara maganin a matsayin manya.

An wajabta wa manya: Ana ɗaukar allunan ƙwayoyin cuta 375 a kowace sa'o'i 8 a kowace rana, allunan 625 MG kowane sa'o'i 12. Lokacin ƙirƙirar magani don magance cututtukan ƙwayar cuta, ana amfani da allurai na 625 MG kowane 8 hours, ko 1000 mg kowane 12 hours.

Ya kamata a lura cewa allunan na iya bambanta a cikin gwargwadon abubuwa masu aiki. Saboda haka, baza ku iya maye gurbin kwamfutar hannu na 625 mg (500 g na amoxicillin da 125 g na clavulanic acid) tare da allunan 375 mg guda biyu (250 g na amoxicillin da 125 g na clavulanic acid).

Domin lura da odontogenic kamuwa da cuta ta amfani da wadannan makirci. Ana ɗaukar allunan 375 MG kowane 8 hours, zagaye agogo. Allunan kwalaji 625 bayan awa 12.

Idan ya zama dole don amfani da magani don kula da marasa lafiya da cututtukan koda, dole ne a la'akari da abun ciki na urinary creatinine. Marasa lafiya tare da cututtukan hanta suna buƙatar sa ido akai-akai game da aikin su.

Foda don dakatarwa ga jarirai da yara har zuwa watanni 3. Ana yin allurar ta amfani da pipette na musamman ko cokali. Sashi - 30 MG na amoxicillin da kilogram na nauyi, sau biyu a rana.

Ga yara sama da watanni uku don cututtuka masu laushi da matsakaici - 20 MG / kilogiram na nauyin jikin mutum, kuma don cututtukan ƙarancin cuta - 40 MG / kg. Hakanan ana amfani da kashi na biyu a cikin maganin cututtukan da ke cikin zurfi - kumburin kunne na tsakiya, sinusitis, mashako, ciwon huhu. Jagora tana haɗe da wannan magani, wanda akwai tebur na musamman waɗanda ke ba ku damar yin lissafin mahimman magungunan magunguna don yara.

Matsakaicin izini na yau da kullun na amoxicillin ga yara shine 45 mg / kg na nauyi, don manya - 6 grams. Ana iya ɗaukar maganin Clavulanic acid kowace rana babu fiye da 600 mg ga manya da 10 mg / kg ga yara.

Bayanin kwatancen saki

Ana samun wannan maganin ta hanyar nau'ikan allunan da aka suturta wadanda suke fari ko fararen fata. Allunan suna da siffar biconvex mai kyau.

Tabletaya daga cikin kwamfutar hannu 625 mg ta ƙunshi 500 mg na amoxicillin trihydrate tare da 125 MG na clavulanic acid (potassium gishiri).

Allunan za'a iya samarwa a cikin gwangwani na filastik (Allunan 15 kowannensu) ko a cikin almishin aluminum na 5 ko 7.

Har ila yau, allunan 1000 MG mai ruwan ciki, suna da siffofi mai kyau tare da yanke gefuna. A kansu, a gefe guda, ana amfani da alamar "AMS", a ɗayan - "875/125". Sun haɗa da 875 MG na kwayoyin rigakafi da 125 MG na clavulanic acid.

Yarda da wasu magunguna

• Abu ne wanda ba a ke so a yi amfani da Amoxiclav tare da shirye-shiryen anticoagulants na kai tsaye. Wannan na iya haifar da karuwa a cikin lokacin prothrombin.
• Abun hulɗa na Amoxiclav da allopurinol yana haifar da haɗarin exanthema.
• Amoxiclav yana haɓaka haɗarin ƙwayar metaterxate.
• Ba za ku iya amfani da amoxicillin da rifampicin ba - waɗannan masu tayar da hankali ne, haɗin da aka haɗu yana raunana tasirin ƙwayoyin cuta na duka biyu.
• Bai kamata a rubuto Amoxiclav tare da tetracyclines ko macrolides (Waɗannan magungunan ƙwayoyin cuta ne na kwayan cuta), tare da sulfonamides saboda raguwar tasirin wannan magani.
• Shan Amoxiclav yana rage tasirin maganin hana haihuwa cikin allunan.

Likitoci suna bita

Anna Leonidovna, therapist, Vitebsk. Amoxiclav ya fi tasiri sosai wajen lura da cututtukan da ke juyar da numfashi fiye da maganin ta analogue, amoxicillin. Na tsara hanya na kwanaki 5, bayan haka ya zama wajibi a ɗauki magunguna waɗanda suka maido da microflora.

Veronika Pavlovna, masanin ilimin uro. Mr. Kryvyi Rih. Wannan magani yana da kyakkyawan sakamako ga cututtukan ƙwayar cuta na ƙwayar cuta. Yana da wuya ya ba da sakamako masu illa, a lokaci guda Ina ba da magungunan antifungal, bayan ɗaukar magunguna don dawo da microflora na al'ada.

Andrei Evgenievich, likitan ENT, Polotsk. Amfani da wannan magani ta allura yana ba ku damar hanzarta dakatar da bayyanar cututtuka da mummunan cuta na matsakaici na gabobin ENT. Magungunan yana magance kumburi na tsakiyar kunne sosai. Bugu da ƙari, marasa lafiya suna ɗaukar dakatarwar 'ya'yan itace mai kyau sosai.

Bayanin maganin

Amoxiclav ya ƙunshi manyan abubuwan biyu. Da farko dai, wannan shine penicillin penisilin - semisynthetic penisillin - amoxicillin, da acid acid na clavulanic. Kowane bangare yana da aikinsa. Amoxicillin yana cikin maganin rigakafi, kodayake, clavulanic acid ba shi da tasiri mai hana ƙwayoyin cuta. Menene manufarta?

Kamar yadda kuka sani, penicillins sune ɗayan rigakafin farko na maganin da aka karɓa a tsakiyar ƙarni na ƙarshe. Yayin amfani da su, sun nuna ingancin ƙarfin su. Amma a lokaci guda, ƙwayoyin cuta da yawa sunyi nasarar haɓaka juriya a kansu. Yaya kariya daga ƙwayoyin cuta daga maganin rigakafi ke aiki?

Amoxicillin yana aiki akan membrane na ƙwayoyin cuta, yana ɗaure ɗayan enzymes waɗanda ke cikin abun da ke ciki. A sakamakon haka, bangon tantanin halitta ya rasa ƙarfi, ya lalace kuma ƙwayoyin cuta ta mutu. Koyaya, nau'ikan ƙwayoyin cuta da yawa sun fara samar da abubuwa na musamman - beta-lactamases, waɗanda ke toshe aikin ƙurar rigakafi. Saboda haka, amoxicillin ya zama marar lahani ga yawancin ƙwayoyin cuta.

Clavulanic acid an tsara shi musamman don yaƙar beta-lactamases. Ta hanyar ɗaure shi da amoxicillin, yana sa ƙwayoyin rigakafi ta rigakafi ga beta-lactamases. An bayyana wannan sakamako dangane da yawancin nau'ikan beta-lactamases da kwayoyin cuta suka samar.

Saboda haka, haɗarin amoxicillin da clavulanic acid yana da mafi kyawun bakan na ayyukan hana ƙwayoyin cuta fiye da tsarkakakken amoxicillin. Idan amoxicillin na iya shafar ƙarancin ƙwayoyin cuta waɗanda ba sa iya samar da beta-lactamases, to, amoxicillin, haɗe tare da acid acid, yana aiki da yawancin ƙwayoyin cuta waɗanda ke haifar da cututtuka. Daga cikin kwayoyin da Amoxiclav zasu iya lalata, akwai duka kwayoyin cuta na gram-tabbatacce kuma gram-korau.

Babban nau'ikan ƙwayoyin cuta waɗanda ke kula da Amoxiclav:

• Tawancik,
• sakkwatocin,
• Shigella
• Klebsiella
• brucella
• echinococcus,
• Helicobacter
• Clostridia
• bashin hemophilic,
• salmonella
• Kare.

Kwayar cuta mai iya canza kwayar cutar ta Amoxiclav:

• enterobacter
• misalai
• chlamydia
• mycoplasmas
• legionella
• Yersinia

da wasunsu.

Pharmacodynamics

Amoxicillin wani sinadari ne wanda yake aiki da kwayoyin cuta da hauka-gram-gram. Yana hana biosynthesis na peptidoglycan, sashi wanda shine ɓangare na tsarin bangon ƙwayoyin ƙwayoyin cuta. Rage raguwar samar da peptidoglycan yana haifar da raguwa a cikin ƙarfin ganuwar tantanin halitta, wanda daga baya ya haifar da lysis da mutuwar ƙwayoyin microorganisms. A lokaci guda, amoxicillin yana kula da aikin beta-lactamases, wanda ke lalata shi, saboda haka tsinkayensa na aikin ƙwayoyin cuta ba ya haɗa da ƙananan ƙwayoyin halittar da ke tattare da wannan enzyme.

Clavulanic acid shine mai hana sinadarin beta-lactamase, tsarin wanda yayi kama da maganin penicillin. Yana da iko don hana yawancin beta-lactamases, waɗanda ke samar da ƙananan ƙwayoyin cuta tare da tabbatar da juriya ga cephalosporins da penicillins. An tabbatar da ingancin dangi na clavulanic acid dangane da sinadarin placmid beta-lactamases, wanda akasari yake tantance juriya game da kwayoyin cuta zuwa maganin rigakafi. Koyaya, abu ɗin bai yi aiki akan nau'in beta chromosome beta-lactamases waɗanda ba a hana su ta hanyar clavulanic acid.

Kasancewar acid na clavulanic acid a cikin Amoxiclav yana ba da damar hana halakar amoxicillin ta hanyar enzymes na musamman - beta-lactamases - da kuma fadada yanayin aikin hana ƙwayoyin cuta na amoxicillin.

Karatuttukan asibiti a cikin in vitro sun tabbatar da girman yanayin aiki na Amoxiclav na ƙananan ƙwayoyin cuta:

• gram-korau anaerobes: nau'ikan halittar Prevotella, Bacteroides fragilis, wasu respecies na halittar Bacteroides, nau'in halittun Porphyromonas, nau'in halittar Capnocytophaga, nau'in halittar Fusobacterium, Fusobacterium nucleatum, Eikenella corrodens,
• anaerobes na gram-tabbatacce: nau'in halittar halittar Peptostreptococcus, Peptostreptococcus magnus, Peptostreptococcus micros, Peptococcus niger, nau'in halittar Clostridium,
• gram-negative aerobes: Vibrio cholerae, Bordetella pertussis, Pasteurella multocida, cutar Haemophilus, Neisseria gonorrhoeae, Moraxella catarrhalis, Helicobacter pylori,
• gram-aerobes: coagulase-korau staphylococci (nuna sha'awa ga methicillin), Staphylococcus saprophyticus (damuwa mai laushi ga methicillin), Staphylococcus aureus (damuwa mai kula da methicillin), Bacillus anthracis, Streptococococococococococote wasu , Nocardia asteroids, Listeria monocytogenes,
• Sauran: Treponema pallidum, Leptospira icterohaemorrhagiae, Borrelia burgdorferi.

Wadannan microorganism masu halin ana nuna su ne ta hanyar karɓar juriya a kan abubuwan da ke tattare da tsarin sunadarai na Amoxiclav:

• gram-tabbatacce aerobes: streptococci na kwayar cutar ta Viridans, huda cutar huhu, enterococcus faecium, kwayoyin halittar Corynebacterium na kwayoyin halittar,
• gram-negative aerobes: kwayoyin halittar dan adam Shigella, Escherichia coli, kwayoyin halittar dan adam Salmonella, kwayoyin halittar Klebsiella, Klebsiella pneumoniae (karatuttukan asibiti sun tabbatar da ingancin abubuwan da suke aiki da su na Amoxiclav dangane da wannan microorganism, nau'ikansa ba su hada beta-lactamases kwayoyin cuta), Klebsiella kwayoyin , Proteus vulgaris, Proteus mirabilis.

Abubuwa masu zuwa sun bayyana juriya ta halitta ga hadewar amoxicillin da acid ta clavulanic:

• gram-korau aerobes: kwayoyin cuta na kwayoyin Acinetobacter, Yersinia enterocolitica, Citrobacter freundii, Stenotrophomonas maltophilia, kwayoyin Enterobacter, kwayoyin Pseudomonas, Hafnia alvei, kwayoyin cutar kwayoyin cutar kwayar cutar, kwayoyin cuta na Legionella pneumophila, bacteriaen Sisenella
• sauran: kwayoyin cuta na kwayoyin Mycoplasma, Chlamydophila psittaci, Chlamydophila pneumoniae, kwayoyin kwayoyin Chlamydia, Coxiella burnetii.

Halin ƙwayar ƙwayar ƙwayar cuta zuwa monotherapy tare da amoxicillin galibi yana nufin irin wannan hankalin game da haɗarin amoxicillin da acid na acid.

Neman Masu haƙuri

Victoria, Dnipropetrovsk. Anyi amfani dashi kamar yadda likita ya umarta don maganin cututtukan ƙwayoyin cuta. Saw 5 days. Kwayar rigakafin ta fara ne a ranar 3 na rashin lafiya. Cutar ta rage ta kashi uku. Ciwona ya daina rauni. An sami zawo, an yi shi a cikin kwana biyu, bayan shi na fara shan probiotics don dawo da microflora.

Alexandra, garin Lugansk. Likita ya ba da wannan maganin don magance pyelonephritis. Aikin ya kasance kwana 7. Na farko kwanaki 3 injections - sannan kwayoyin hana daukar ciki. Inanƙwalwa suna da zafi sosai. Koyaya, ci gaba ya fara a rana ta huɗu. Babu wani sakamako masu illa. Wancan bushewar bakin.

Tamara, garin Boyarka. Sun saka mani wannan magani don maganin cututtukan cututtukan mahaifa. Yana da matukar raɗaɗi, raunin ya kasance a wurin allura. Koyaya, bayan mako guda babu alamar da aka bari a cikin smears daga pathogen.

Informationarin Bayani

Idan ana amfani da maganin na dogon lokaci, wajibi ne don saka idanu kan aikin hanta, gabobin da ke cikin jini da kodan mai haƙuri. Idan mai haƙuri ya sami rauni na aikin koda, ya zama dole don daidaita sashi ko ƙara tsakanin tazara tsakanin ƙwayoyi. Zai fi kyau a sha magani da abinci. Game da superinfection (bayyanar microflora insensitive ga wannan ƙwayar rigakafin ƙwayar cuta), wajibi ne don canza maganin. Sakamakon yiwuwar halayen ƙwayar cuta tare da cephalosporins a cikin marasa lafiya da ke kula da maganin penicillins, ba a son yin amfani da waɗannan ƙwayoyin rigakafi a lokaci guda.

Lokacin shan magani, kuna buƙatar sha babban adadin ruwa don guje wa samuwar lu'ulu'u na amoxicillin a cikin fitsari.

Ya kamata ka sani cewa kasancewar yawan allurar rigakafi a cikin jiki na iya tayar da martani na qarya ga fitsari (idan aka yi amfani da maganin na Benedict ko kuma Fleming na maganin Fleming). Sakamakon abin dogara a wannan yanayin zai ba da damar yin amfani da enzymatic amsawa tare da glucosidase.

Tunda tasirin sakamako daga tsarin mai juyayi yana yiwuwa lokacin amfani da miyagun ƙwayoyi, ya wajaba don fitar da hankali sosai a kan abubuwan hawa (motoci) ko shiga cikin ayyukan da ke buƙatar ƙara yawan hankali, saurin amsawa da kulawa.

An sake shi kan takardar sayan magani.

Allunan da kuma bayani don maganin dakatarwa

Sabunta magunguna da tsawon lokacin shan magani ana ƙaddara su gwargwadon tsananin kamuwa da cuta, shekaru, aikin koda da haƙuri. A cikin allunan da dakatarwa, ana bayar da shawarar Amoxiclav tare da abinci, wanda zai rage haɗarin sakamako masu illa daga tsarin narkewa.

Matsakaicin karatun shine daga 5-14 kwana. Dogon magani zai yuwu ne kawai bayan gwajin likita na biyu.

Dokar da aka ba da shawarar don allunan Amoxiclav ga yara 'yan shekara 12 shine 40 mg / kg a kowace rana, wanda ya kasu kashi uku. Yaran da nauyin jikinsu ya wuce kilogiram 40 ana nuna musu matakan tsufa na miyagun ƙwayoyi. Ga yara 'yan kasa da shekaru 6, ya fi dacewa a yi amfani da dakatarwar Amoxiclav.

Akwai makirci guda biyu don ɗaukar Amoxiclav a cikin manya tare da kamuwa da cuta mai sauƙi zuwa matsakaici:

• Kowane 8 hours, 1 kwamfutar hannu 1 250 + 125 MG,
• Kowane sa'o'i 12, 1 kwamfutar hannu 500 + 125 MG.

A kan tushen kamuwa da cuta mai tsanani kuma tare da cututtukan ƙwayar cuta na huhu, 1 kwamfutar hannu na 500 + 125 MG ya kamata a dauki kowane 8 awa ko 1 kwamfutar hannu na 875 + 125 MG kowane 12 hours.

Tare da kamuwa da cuta na odontogenic, gudanarwa na 1 kwamfutar hannu na Amoxiclav 250 + 125 mg kowane 8 hours ko 1 kwamfutar hannu na 500 + 125 MG kowane 12 12 yana nuna kwanaki 5.

An wajabta Amoxiclav a cikin jarirai da yara har zuwa watanni 3 a cikin nau'i na dakatarwa a cikin adadin 30 mg / kg a kowace rana (bisa ga amoxicillin). Ana shan maganin kowane awa 12. Don bin ka'idodin sashi, yi amfani da pipette sashi wanda aka kawo tare da kunshin.

Yawan maganin Amoxiclav na yau da kullun ga yara sama da watanni 3 shine:

• Tare da m zuwa matsakaici mai ƙarfi na cutar - daga 20 MG / kg a kowace rana,
• A cikin cututtukan da ke cikin raɗaɗi kuma a cikin cututtukan cututtukan ƙananan ƙwayar cuta, otitis media, sinusitis - har zuwa 40 mg / kg (amoxicillin) kowace rana.

Ya kamata a ɗauka a cikin zuciya cewa lokacin yin lissafin magunguna, mutum bai kamata ya dogara da shekarun yarinyar ba, amma akan nauyin jikinsa da tsananin cutarwar cutar.

Magani don allura

Ana gudanar da maganin Amoxiclav a cikin hanyar samar da mafita don allura ta musamman.

Ga yara 'yan ƙasa da watanni 3, ana yin lissafin kashi gwargwadon bayanan da ke gaba:

• nauyin jiki kasa da 4 kilogiram: Ana gudanar da maganin Amoxiclav a cikin sashi na 30 MG / kg (yin la'akari da juyawa ga maganin gaba daya) kowane sa'o'i 12,
• nauyin jiki sama da 4 kilogiram: Ana gudanar da maganin Amoxiclav a gwargwadon nauyin 30 MG / kg (la'akari da canzawa zuwa maganin gaba daya) kowane 8 hours.

Yaran da ba su kai watanni 3 da haihuwa ba, ya kamata a ba da allurar ne kawai a hankali har zuwa minti 30-40.

Ga yara waɗanda nauyin jikinsu ba ya wuce 40 kilogiram, an zaɓi sashi yana yin la'akari da nauyin jikin mutum.

Ga yara daga watanni 3 zuwa shekaru 12, ana gudanar da maganin ne a gwargwadon nauyin 30 MG / kg nauyin jiki (cikin yanayin maganin gaba daya) kowane 8 hours, kuma idan akwai mummunan kamuwa da cuta, kowane 6 hours.

A cikin yara masu fama da cututtukan ƙwayar cuta na yara, za a buƙaci daidaitawa kashi bisa gwargwadon iyakar shawarar amoxicillin. Idan a cikin irin wannan marassa lafiyar creatinine ya wuce 30 ml / min, canjin kashi shine na tilas ne. A wasu halaye, a cikin yara waɗanda nauyin jikinsu ba ya wuce 40 kilogiram, ana bada shawarar yin amfani da Amoxiclav a cikin sigogin masu zuwa:

• KK 10-30 ml / min: 25 mg / 5 MG a 1 kg na nauyin jiki kowane awa 12,
• CC kasa da 10 ml / min: 25 mg / 5 MG a 1 kg na nauyin jikin kowane awa 24,
• hemodialysis: 25 MG / 5 MG a 1 kilogiram na nauyin jikin kowane awa 24 a hade tare da ƙarin kashi na 12.5 mg / 2.5 MG a 1 kilogiram na nauyin jiki a ƙarshen zaman dialysis (hade da raguwa a cikin taro na acid acid da amoxicillin a cikin jini).

Kowane MG 30 na miyagun ƙwayoyi ya ƙunshi 25 mg na amoxicillin da 5 MG na clavulanic acid.

Ga manya da yara sama da shekara 12 ko yin nauyi sama da kilo 40, ana gudanar da Amoxiclav a sashi na 1200 MG na miyagun ƙwayoyi (1000 mg + 200 mg) a kowane sa'o'i 8, kuma a yanayin saurin kamuwa da cutar sankara - kowane 6 hours.

Hakanan ana ƙaddara Amoxiclav don ayyukan tiyata a cikin ƙwayar prophylactic, wanda yawanci shine 1200 MG tare da haifar da maganin sa barci a cikin yanayin inda aikin ya ɗauki ƙasa da awanni 2. Tare da tsarancin tiyata mafi tsayi, mai haƙuri yana karɓar ƙwayar a cikin ƙwayar 1200 MG har zuwa sau 4 don kwana 1.

A cikin marassa lafiyar da ke fama da gazawar renal, kashi da / ko lokacin tazara tsakanin gudanarwar Amoxiclav yakamata a daidaita ta gwargwadon matsayin aikin nakasassu na aiki daidai da umarnin da ke tafe:

• CC fiye da 30 ml / min: babu buƙatar daidaita sashi,
• KK 10-30 ml / min: kashi na farko shine 1200 mg (1000 mg + 200 mg), bayan haka ana sarrafa maganin a cikin kwayar cutar ta 600 mg (500 mg + 100 mg) a kowane sa'o'i 12,
• CC kasa da 10 ml / min: kashi na farko shine 1200 mg (1000 mg + 200 mg), bayan haka ana sarrafa maganin a cikin kwayar cutar ta 600 mg (500 mg + 100 mg) a kowane sa'o'i 24,
• cutar kansa: a tazara tsakanin injections na miyagun ƙwayoyi zuwa 48 hours ko fiye.

Tunda yayin aikin hemodialysis har zuwa 85% na maganin da aka cire na Amoxiclav an cire, a ƙarshen kowane zaman, ya kamata a gudanar da kashi na al'ada na maganin allura. Tare da dialysis na peritoneal, babu buƙatar gyaran kashi.

Tsawon lokacin aikin zai kasance ne daga 5 zuwa 14 kwanaki (kawai likitan halartar ne zai iya tantance ainihin lokacin shi). Tare da raguwa a cikin tsananin bayyanar cututtuka, miƙa mulki ga baka siffofin na Amoxiclav bada shawarar a ci gaba da far.

Lokacin shirya maganin allurar, abun ciki na vial a cikin adadin 600 MG (500 MG + 100 MG) an narke cikin 10 ml na ruwa don allura, kuma a cikin adadin 1200 MG (1000 mg + 200 MG) a cikin 20 ml na ruwa don allura (wannan ba a bada shawarar wannan girman ba. wuce). Ana gudanar da maganin a hankali cikin hanzari (fiye da mintuna 3-4), kuma ya kamata a aiwatar da gabatarwar cikin minti 20 bayan shiri na mafita.

Hakanan za'a iya amfani da maganin Amoxiclav don shigarwar ciki. A wannan yanayin, shirye-shiryen da aka shirya dauke da 1200 MG (1000 mg + 200 mg) ko 600 MG (500 MG + 100 MG) na miyagun ƙwayoyi an gurza su cikin 100 ml ko 50 ml na maganin jiko, bi da bi. Tsawon jiko ya kai minti 30-40.

Yin amfani da taya mai biyowa a cikin kundin da aka ba da shawarar zai ba ku damar adana abubuwan da ake buƙata na amoxicillin a cikin hanyoyin jiko. Lokacin zaman su ya bambanta da adadin zuwa:

• don ruwa don yin allura: 4 awanni a 25 ° C da awanni 8 a 5 ° C,
• don maganin sinadarin sodium chloride da alli na chloride don jiko na ciki: 3 sa'o'i a 25 ° C,
• don maganin ringer na maganin lactate don jiko na ciki: 3 sa'o'i a 25 ° C,
• don sodium chloride 0.9% don jiko na ciki: 4 hours a 25 ° C da 8 hours a 5 ° C.

Kada a haɗar da maganin Amoxiclav tare da sodium bicarbonate, dextran ko mafita na dextrose. Kadai bayyananne mafita ne kawai za'a gudanar dashi. Maganin da aka shirya dole ba zai daskarewa ba.

Tasiri a kan ikon tuka motoci da abubuwa masu rikitarwa

Idan yayin jiyya tare da miyagun ƙwayoyi ana gano mai haƙuri da halayen da ba a so daga tsarin juyayi na tsakiya (alal misali, rashi ko jin ƙwaya), ana ba da shawarar guji tuki motoci da yin aikin da ke buƙatar haɓakar mai da hankali da halayen psychomotor kai tsaye.

Haihuwa da lactation

A cikin gwaje-gwajen dabbobi, ba a tabbatar da lahanin shan Amoxiclav a lokacin daukar ciki da tasirin magani a ci gaban tayin ba. A cikin bincike guda daya wanda ya shafi matan da suka lalace daga cikin membranes na amniotic, an gano cewa yin amfani da prophylactic na hade da amoxicillin da clavulanic acid na iya kara hadarin kamuwa da cututtukan enterocolitis a cikin jarirai.

A lokacin daukar ciki da kuma lactation, ana bada shawarar amfani da Amoxiclav ne kawai idan amfanin amfanin magani ga uwa ya wuce mafi girman hadarin da ke tattare da lafiyar tayin da yaro. Clavulanic acid da amoxicillin a cikin ƙananan hankali an ƙaddara su a cikin madara. A cikin jarirai masu shayar da nono, zazzabin cizon sauro, jijiyoyin jiki, candidiasis na mucous membranes na bakin ciki na iya haɓaka, don haka idan ya zama dole a bi da ƙwayar, yana da kyau a daina shayar da nono.

Tare da nakasa aiki na koda

Marasa lafiya tare da gazawar na koda na matsakaici (CC ya bambanta daga 10 zuwa 30 ml / min) ana bada shawarar ɗaukar kwamfutar hannu ta Amoxiclav 1 (kashi na 500 mg / 125 mg ko 250 mg / 125 mg dangane da tsananin cutar) a kowane sa'o'i 12, kuma tsananin gazawar koda (CC kasa da 10 ml / min) - 1 kwamfutar hannu (kashi na 500 mg / 125 mg ko 250 mg / 125 mg dangane da tsananin cutar) a kowane sa'o'i 24.

Kashi na farko na mafita don gudanarwar cikin ciki tare da CC na 10-30 ml / min shine 1000 mg / 200 mg, sannan 500 MG / 100 MG kowane 12 hours. Tare da CC kasa da 10 ml / min, kashi na farko na mafita don gudanarwar cikin ciki shine 1000 mg / 200 mg, sannan 500 MG / 100 MG kowane 24 hours.

A cikin anuria, tazara tsakanin allurai na Amoxiclav zuwa 48 hours ko fiye.

Hulɗa da ƙwayoyi

Yawan cin abinci na ascorbic acid tare da Amoxiclav yana haɓaka ɗaukar abubuwan da ke aiki, da kuma yawan aminoglycosides, antacids, laxatives, glucosamine - yana rage yawan shansu. Yin amfani da magungunan anti-mai hana kumburi (NSAIDs), diuretics, phenylbutazone, allopurinol da sauran magunguna waɗanda ke toshe ɓoyayyen tubular (probenecid) yana ƙara matakin amoxicillin a cikin jiki (clavulanic acid an cire shi da farko ta hanyar lalata duniya). Haɗin Amoxiclav da probenecid na iya haifar da ƙaruwa a cikin ƙarfin jini da haɗuwa da amoxicillin, amma ba clavulanic acid ba, saboda haka haramcin amfani da kwayoyi a lokaci guda.

Haɗin amoxicillin, clavulanic acid da methotrexate yana haɓaka abubuwan da ke cikin guba na methotrexate. Yin amfani da magani tare da allopurinol na iya tayar da haɓakar halayen fata. Ba'a ba da shawarar yin amfani da Amoxiclav tare da haɗin disulfiram ba.

Haɗin amoxicillin da clavulanic acid yana rage tasirin magungunan wanda metabolism ɗinsa ke haifar da haifar da para-aminobenzoic acid, kuma idan aka dauki shi tare da estinio estradiol, haɗarin haɓakar "fashewa" na zubar jini.

A cikin wallafe-wallafen, akwai 'yan rahotanni game da karuwa a cikin ƙayyadaddun ƙasashen duniya (INR) a cikin marasa lafiya tare da kulawa na lokaci guda na amoxicillin da warfarin ko acenocoumarol. Idan ya zama dole a hada Amoxiclav tare da maganin anticoagulants, ana ba da shawarar saka idanu akai-akai na INR ko lokacin prothrombin lokacin da aka soke ko fara magani tare da miyagun ƙwayoyi, tunda ana buƙatar daidaita sashi na maganin anticoagulants da aka faɗa a baki.

Gudanar da maganin amoxicillin / clavulanic acid tare da rifampicin zai iya haifar da rauni ga juna game da tasirin ƙwayoyin cuta. Ba a shawarar Amoxiclav ko da sau ɗaya a hade tare da kwayoyin rigakafin ƙwayoyin cuta (tetracyclines, macrolides) da sulfonamides saboda yiwuwar raguwar tasirin amoxicillin / clavulanic acid.

Shan maganin yana rage tasirin maganin hana haifuwa. A cikin marasa lafiya suna shan mofetil na mycophenolate, bayan fara magani tare da Amoxiclav, akwai raguwa a cikin abun da ke ciki na metabolite mai aiki a cikin jiki - mycophenolic acid - kafin shan kashi na gaba na miyagun ƙwayoyi da kusan 50%. Bambanci a cikin maida hankali ba zai iya yin daidai daidai canje-canje a cikin bayyanar wannan metabolite.

Abubuwan da ake kira Amoxiclav analogues sune:

• Ta hanyar abu mai aiki - Bactoclav, Clamosar, Arlet, Panklav, Medoklav, Liklav, Augmentin, Rapiklav, Fibell, Ekoklav, Amovikomb, Amoksivan,
• Ta hanyar tsarin aiki - Libacil, Oxamp, Santaz, Ampioks, Tazotsin, Timentin, Sulacillin, Ampisid.

Farashin Amoxiclav a cikin magunguna

Kimanin farashin Amoxiclav a cikin nau'ikan Allunan tare da sashi na 875 mg / 125 mg shine 401-436 rubles (14 a kowace fakiti), sashi na 500 mg / 125 mg shine 330-399 rubles (15 a kowace kunshin), 250 mg / 125 mg - 170‒241 rubles (kunshin ya ƙunshi 15 inji mai kwakwalwa.). Foda don shirye-shiryen dakatarwa don gudanar da magana ta baka tare da sashi na 400 MG / 57 MG za'a iya siye don kimanin 158-73 rubles, sashi na 250 mg / 62.5 MG don 212-29 rubles, sashi na 125 mg / 31.25 mg - 99-1123 rubles . Foda don shirya allura don allura tare da sashi na 1000 mg / 200 mg zai biya kimanin 675-862 rubles, tare da sashi na 500 MG / 100 MG - 465-490 rubles (kowane kunshin ya ƙunshi 5 kwalabe).

Analogues na miyagun ƙwayoyi

Cikakken tsarin analogues na Amoxiclav sun hada da kwayoyi masu dauke da amoxicillin da clavulanic acid, alal misali, Augmentin, Flemoklav Solutab. Shirye-shiryen da ke kunshe da amoxicillin kadai ba zai zama wani gurbi wanda zai iya canzawa ba saboda jerin kananan halittu masu hankali da ke tattare da tsarkakakken amoxicillin sun fi na Amoxiclav. Hakanan ana iya faɗi game da wasu magunguna na ƙungiyar penicillin - ikon yin amfani da ƙila ba za ta zo daidai da ikon aikace-aikacen Amoxiclav ba.

Form sashi

Allunan mai rufe fim

Abubuwan da ke aiki (ainihin): kowace kwamfutar hannu 250mg + 125mg ta ƙunshi 250 mg na amoxicillin a cikin nau'in trihydrate da 125 mg na clavulanic acid a cikin nau'i na potassium mai gishiri,
kowane ƙwayar 500 mg + 125 mg kwamfutar hannu ta ƙunshi 500 mg na amoxicillin a cikin nau'in trihydrate da 125 mg na clavulanic acid a cikin nau'i na potassium,
kowane ƙwayar 875 mg + 125 mg kwamfutar hannu ya ƙunshi 875 mg na amoxicillin a cikin nau'i na trihydrate da 125 mg na clavulanic acid a cikin nau'i na potassium potassium.
Fitowa (gwargwadon kowane sashi): colloidal silicon dioxide 5.40 mg / 9.00 mg / 12.00 mg, crospovidone 27.40 mg / 45.00 mg / 61,00 mg, croscarmellose sodium 27.40 mg / 35,00 mg / 47,00, magnesium stearate 12.00 mg / 20.00 mg / 17.22 mg, talc 13.40 mg (don sashi 250 mg + 125 mg), celclostse microcrystalline har zuwa 650 mg / har zuwa 1060 mg / har zuwa 1435 mg,
Allunan shafi fim 250mg + 125mg - hypromellose 14.378 mg, ethyl cellulose 0.702 mg, polysorbate 80 - 0.780 mg, triethyl citrate 0.793 mg, titanium dioxide 7.605 mg, talc 1.742 mg,
Allunan shafi fim 500mg + 125mg - hypromellose 17.696 mg, ethyl cellulose 0.864 mg, polysorbate 80 - 0.960 mg, triethyl citrate 0.976 mg, titanium dioxide 9.360 mg, talc 2.144 mg,
Allunan shafi fim 875mg + 125mg - hypromellose 23.226 mg, ethyl cellulose 1.134 mg, polysorbate 80 - 1.260 mg, triethyl citrate 1.280 mg, titanium dioxide 12.286 mg, talc 2.814 mg.

Bayanin

Allunan 250 mg + 125 mg: fari ko kusan fararen fata, oblong, octagonal, biconvex, allunan da aka sanya fim tare da kwafin 250/125 a gefe guda da AMC a gefe guda.
Allunan 500 MG + 125 MG: fari ko kusan fari, m, allunan biconvex, mai rufe fim.
Allunan 875 mg + 125 allunan: fari ko kusan fararen fari, oblong, biconvex, allunan da aka sanya fim da kwarewa da kuma “875/125” a gefe guda da “AMC” a daya gefen.
Duba kan wani kink: taro mai launin shuɗi.

Kayan magunguna

Pharmacodynamics
Hanyar aikin
Amoxicillin shine penicillin wanda yake aiki da hakoran kwayoyi wanda yake da aiki da kwayoyin cuta masu inganci da kuma na gwaje-gwaje da yawa. Amoxicillin ya rushe biosynthesis na peptidoglycan, wanda shine tsarin tsarin jikin bangon ƙwayar cuta. Take hakkin aiki na peptidoglycan yana haifar da asarar ƙarfi na bangon tantanin halitta, wanda ke haifar da lysis da mutuwar ƙwayoyin ƙwayoyin cuta. A lokaci guda, amoxicillin yana da saukin kamuwa da lalacewa ta hanyar beta-lactamases, sabili da haka bakan aikin amoxicillin baya wuce zuwa microorganisms waɗanda ke samar da wannan enzyme.
Clavulanic acid, wani sinadarin beta-lactamase inhibitor wanda ya shafi penicillins, yana da ikon hana nau'ikan beta-lactamases da aka samo a cikin maganin penicillin da cephalosporin mai jure kwayoyin. Clavulanic acid yana da isasshen inganci ga maganin plasmid beta-lactamases, wanda galibi yakan haifar da juriya na kwayar cuta, kuma baya tasiri akan nau'in beta chromosome beta-lactamases, wanda acid ba ya hana shi.
Kasancewar acid na clavulanic a cikin shirye-shiryen yana kare amoxicillin daga lalacewa ta hanyar enzymes - beta-lactamases, wanda ke ba da damar fadada ƙwayoyin ƙwayoyin cuta na amoxicillin.
Mai zuwa shine ayyukan haɗin inzara na amoxicillin tare da acid clavulanic.

Pharmacokinetics
Babban ma'aunin magunguna na amoxicillin da clavulanic acid sun yi kama. Amoxicillin da clavulanic acid sun narke sosai cikin mafita mai ruwa tare da pH na ilimin halittar jiki kuma, bayan shan Amoxiclav ® a ciki, suna da sauri kuma suna karɓe shi daga ƙwayar gastrointestinal (GIT). Amfani da abubuwa masu aiki na amoxicillin da clavulanic acid shine mafi kyau idan an sha a farkon cin abinci.
A bioavailability na amoxicillin da clavulanic acid bayan maganin baka shine kusan kashi 70%.
Ana ba da sigogi na pharmacokinetic na amoxicillin da clavulanic acid a ƙasa bayan gudanarwa a kashi 875 mg / 125 mg da 500 mg / 125 mg sau biyu a rana, 250 mg / 125 mg sau uku a rana ta masu aikin sa kai na lafiya.

Rarraba
Abubuwan guda biyu suna haɗuwa da ingantaccen girma na rarraba a cikin gabobin daban-daban, kyallen takarda da ruwan jiki (ciki har da a cikin huhu, gabobin ciki, tsotse, ƙashi da ƙashin tsoka, pleural, synovial da ruwa mai gudana, a cikin fata, bile, fitsari, far fitowar ruwa, maniyyi, cikin ruwa mai shiga).
Proteinaddamarwar furotin na Plasma matsakaici ne: 25% na clavulanic acid da 18% na amoxicillin.
Volumeimar rarraba shine kusan 0.3-0.4 L / kg don amoxicillin da kimanin 0.2 L / kg don acid acid na clavulanic.
Amoxicillin da acid na clavulanic basa ƙetare shinge na jini-kwakwalwa a cikin meninges wanda ba a rufe shi ba.
Amoxicillin (kamar yawancin penicillins) an keɓe shi a cikin madara. An kuma samo nau'ikan acid na clavulanic acid a cikin madarar nono. Amoxicillin da acid na clavulanic sun ƙetare shinge na jini.
Tsarin rayuwa
Kimanin kashi 10-25% na kashin farko na amoxicillin an cire shi ta hanyar ƙwayar penicilloic acid mara aiki. Acid na Clavulanic a jikin dan Adam yana gudanar da aiki mai karfi sosai ta hanyar samarda 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid da kuma 1-amino-4-hydroxy-butan-2-daya kuma kodan ya raba shi, ta hanyar narkewa, har da iska mai narkewa, a cikin nau'in carbon dioxide.
Kiwo
Amoxicillin ne aka raba shi da kodan, yayin da acid na clavulanic ta hanyar injina da kuma karin abubuwa. Bayan gudanar da magana guda ɗaya na kwamfutar hannu guda 250 na 250 mg / 125 mg ko 500 mg / 125 mg, kimanin 60-70% na amoxicillin da 40-65% na clavulanic acid ba su canzawa tare da kodan a cikin awanni 6 na farko.
Matsakaicin rabin-rayuwa (T1 / 2) na amoxicillin / clavulanic acid shine kusan awa ɗaya; matsakaiciyar ɗaukar kusan shine 25 l / h a cikin marasa lafiya.
Mafi yawan adadin acid ɗin clavulanic an keɓance shi a cikin awanni 2 na farko bayan gudanarwa.
Marasa lafiya tare da nakasa aiki na renal
Adadin jimlar amoxicillin / clavulanic acid yana raguwa a gwargwadon raguwa a aikin aikin koda. Rage yarda ya zama mafi ƙira ga amoxicillin fiye da na clavulanic acid, saboda Mafi yawan amoxicillin suna dauke da kodan. Allurai na miyagun ƙwayoyi don gazawar renal ya kamata a zaɓi yin la'akari da undesirability na tarawa na amoxicillin yayin riƙe da matakin al'ada na clavulanic acid.
Marasa lafiya tare da nakasa aikin hanta
A cikin marasa lafiya da ke fama da aikin hanta, ana amfani da miyagun ƙwayoyi tare da taka tsantsan, ya zama dole a kula da aikin hanta koyaushe.
Dukkanin abubuwan guda biyu ana cire su ta hanyar cututtukan hemodialysis da adadi kaɗan ta hanyar ƙirar bugun jini.

Yi amfani da lokacin daukar ciki da lokacin shayarwa

Karatun dabbobi bai bayyana bayanai game da hatsarorin shan miyagun ƙwayoyi ba yayin daukar ciki da tasirin sa ga cigaban tayi.
A cikin binciken daya a cikin mata masu rikicewar ƙwayar cuta na meniotic membranes, an gano cewa prophylactic amfani da amoxicillin / clavulanic acid na iya haɗuwa da haɓakar haɗarin kamuwa da cutar encrotizing enterocolitis a cikin jarirai.
A lokacin daukar ciki da lactation, ana amfani da maganin ne kawai idan amfanin da aka yi niyya ga uwa ya fi girman hadarin da tayi ga jaririn da jariri.
Amoxicillin da acid na clavulanic a cikin adadi kaɗan sun shiga cikin nono.
A cikin jarirai masu karbar nono, haɓakar jiyya, zawo, candidiasis na mucous membranes na bakin ciki yana yiwuwa. Lokacin shan Amoxiclav ®, ya wajaba don yanke shawara akan dakatar da shayarwa.

Side sakamako

A cewar Hukumar Lafiya ta Duniya (WHO), ana rarraba tasirin da ba a ke so gwargwadon yawan ci gaban su kamar haka: sau da yawa (≥1 / 10), sau da yawa (≥1 / 100), daga cututtukan gastrointestinal
sau da yawa sosai: zawo
galibi: tashin zuciya, amai. Rage ciki shine mafi yawan lokuta yayin lura da yawan allurai.
Idan an tabbatar da cin zarafin ƙwayar gastrointestinal, za'a iya kawar da su idan kun sha maganin a farkon abincin.
a koyaushe: narkewa cikin fushi
da wuya kwayoyin cuta masu hadewar kwayoyi (ciki harda basur da cututtukan cututtukan mahaifa), baki “mai gashi”, baki, stomatitis.
A wani ɓangaren hanta da ƙwayar biliary
a koyaushe: haɓaka ayyukan alanine aminotransferase (ALT) da / ko rarraba aminotransferase (AST). Ana lura da waɗannan halayen a cikin marasa lafiya da ke karɓar maganin ƙwayoyin cuta na beta-lactam, amma ba a san mahimmancin asibiti ba.
da wuya jalestice cholestatic, hepatitis, yawan aiki na alkaline phosphatase, karuwar ayyukan bilirubin a cikin jini.
An lura da mummunan halayen daga hanta musamman a cikin maza da tsofaffi marasa lafiya kuma yana iya hade da jiyya na dogon lokaci. Ba a taɓa ganin irin wa] annan halayen ba a cikin yara.
Alamun da alamomin da aka lissafa yawanci suna faruwa ne a lokacin ko kuma kai tsaye bayan ƙarshen maganin, duk da haka a wasu halaye waɗanda ba za su iya bayyana ba a cikin makonni da yawa bayan kammala maganin. Abubuwan da ba su dace ba galibi ana juyawa.
Rashin halayen daga hanta na iya zama mai wahala, a lokuta mafi ƙarancin gaske akwai rahotannin sakamakon rashin lafiya. A kusan dukkan halayen, waɗannan mutane ne da ke ɗauke da cutar ta cuta ko waɗanda ke karɓar magungunan hepatotoxic lokaci guda.
Daga tsarin rigakafi
da wuya angioedema, cututtukan cututtukan cututtukan ƙwayar cuta, rashin lafiyar jijiyoyin jiki,
A wani ɓangaren jini da tsarin lymphatic
da wuya: leukopenia mai iya juyawa (ciki har da neutropenia), thrombocytopenia,
da wuya farfadowa agranulocytosis, hemolytic anemia, farfadowa da lalacewa a cikin lokacin prothrombin, sake canzawar lokacin zubar jini (duba sashin "Umarni na Musamman"), eosinophilia, thrombocytosis.
Daga tsarin juyayi
a koyaushe: farin ciki, ciwon kai,
da wuya rashi (na iya faruwa a cikin marasa lafiya da ke fama da rauni na aikin koda, har da lokacin ɗaukar manyan magunguna), juyawar damuwa, tashin zuciya, tashin hankali, tashin zuciya, canjin hali, tashin hankali.
A wani ɓangaren fata da ƙwaƙwalwar fata
a koyaushe: fata fata, pruritus, urticaria,
da wuya: erythema multiforme exudative,
da wuya exfoliative dermatitis, Stevens-Johnson syndrome, m keɓaɓɓen exanthematous pustulosis, wani ciwo mai kama da cutar sankara, mai guba da epacmal necrolysis.
Daga kodan da hujin hanji
da wuya interstitial nephritis, crystalluria (duba sashe "overdose"), hematuria.
Cututtuka da cututtukan fata
galibi: candidiasis na fata da ƙwayoyin mucous.
Sauran
ba a sani ba mita: ci gaba da m microorganisms.

Mai masana'anta

Mariƙin RU: Lek dd, Verovshkova 57, 1526 Ljubljana, Slovenia,
An sanya: Lek dd, Perzonali 47, 2391 Prevale, Slovenia.
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