Insulin Tresiba: bita, bita, umarni don amfani

Tresiba FlexTouch wani aikin insulin ne wanda yake daukar lokaci mai tsawo ana amfani dashi don kula da ciwon sukari da ya dogara da su. A cikin labarin za mu bincika umarnin don amfani da miyagun ƙwayoyi "Tresiba".

Hankali! A cikin rarrabuwa na ansar-kemikal-sunadarai (ATX), "Tresiba" aka nuna ta lambar A10AE06. Sunan kasa da kasa mai zaman kanta (Treshiba INN): Insulin Degludec.

Babban aiki abu:

Tresiba kuma yana dauke da tsofaffi.

Magunguna da magunguna: bayanin matakin

Dangane da bincike-binciken vitro, ID shine agonist na masu karɓar insulin, amma ba shi da kusanci ga masu karɓa don haɓakar insulin-kamar haɓaka. Ana samun masu karɓar insulin a cikin kusan dukkanin sel a cikin adadin dabam. Kwayoyin jini suna da masu karɓar ɗari kawai, yayin da ƙwayoyin hanta da ƙwayoyin mai sun bayyana da yawa dubu ɗari. Masu karɓar insulin suna cikin kwayar sel kuma, saboda haka, suna cikin rukunin masu karɓar kayan tunawa.

An kwatanta kwatancen magunguna na ID, musamman, tare da insulin glargine (IG). Matsakaicin rabin plasma rabin sa'a 25 ne (insulin glargine: awa 12). Tsawon lokacin ID shine akalla awanni 42. Tun da ID yana da alaƙa da albumin, matakan plasma ba za a iya daidaita su kai tsaye tare da matakan glargine na insulin ba. Koyaya, ayyukan insulin guda biyu ana iya gwada su da ƙimar glucose. Dangane da binciken, a cikin marasa lafiya da ke dauke da ciwon sukari na 1, ID yana rage yawan glucose a cikin jini.

Alamu da magunguna don amfani da maganin

An kwatanta Tresiba a mafi yawan lokuta tare da glargine. A cikin 'yan shekarun nan, an buga wasu daga cikin wadannan karatun. Conductedaya daga cikin waɗannan karatun da aka gudanar a cikin mutanen da aka kula dasu da insulin na shekara 1. Daga cikin mahalarta taron 629, 472 sun karbi ID kuma 157 sun sami IG. A cikin duka rukunin, HbA1c ya ragu a kan matsakaici da 0.4% sama da shekara guda, kuma a cikin duka rukunin biyu ana samun darajar HbA1c wanda ba kasa da 7%.

An gudanar da irin wannan binciken a cikin mutanen da ke fama da rashin lafiyar insulin-da ke fama da cutar siga. An bai wa marasa lafiya Treshiba na shekaru 2 kuma ana auna yawan monosaccharides a cikin jini akai-akai. Masana kimiyya sun yanke shawara cewa magani ya fi dacewa kuma na dogon lokaci yana rage glycemia fiye da IG.

Babban binciken har zuwa yau a cikin shirin Farashi ya haɗa da mutane 1,030 da ke da nau'in ciwon sukari na 2 waɗanda ba su sami insulin ba kafin gwajin. Mutane 773 sun karbi ID, 257 - IG, dukkan su ma sun dauki metformin. Bayan shekara guda na jiyya, HbA1c ya kasance 1.06% ƙananan a cikin rukunin ID. Abubuwan da ke haifar da sakamako sun kasance iri ɗaya a cikin duka rukunin biyu, amma an gano cutar rashin ƙarfi a cikin marasa lafiya da ke shan Tresiba.

A cikin binciken na makonni 26, jimlar mutane 927 da ke dauke da nau'in ciwon sukari na 2 sun halarci. Groupungiya 1 ta karɓi ID (safe da maraice), kuma na biyu - IG. Magungunan sun rage yawan ƙwayar cutar glycemia da inganta yanayin marasa lafiya.

Studiesarin binciken ya nuna cewa ana iya ba da ID a tazara daban-daban a cikin ƙananan kima (200 U / ml). Ko da tare da canji mai mahimmanci a cikin tazara na gudanarwa (daga 8 zuwa 40 hours), ID na iya isa ga ƙimar HbA1c, waɗanda ba su da bambanci sosai da ƙimar halayyar IG a kai a kai.

Ba'a bada shawarar amfani da miyagun ƙwayoyi don amfani da yaro underar shekara 6 ba. Hakanan haramun ne a sha magani tare da nuna rashin damuwa ga abu mai aiki.

Side effects

Dangane da binciken da Hukumar Kula da Abinci da Magunguna ta Amurka (FDA), hypoglycemia yawanci yakan faru a cikin marasa lafiya da dare. Idan an bayyana "dare" daban da (daga 2 zuwa 6 hours ko tsakar dare zuwa 8 hours), to babu mahimman bambance-bambance.

Game da abubuwan da suka faru na zuciya yayin jiyya, nazarin farko bai nuna bambanci sosai tsakanin ID da sauran magunguna ba. Koyaya, wani bincike da FDA, wanda a cikin mafi yawan yanayi aka bayyana ma'anar cututtukan zuciya, ya nuna cigaba a tsakanin IDs don yawan tashin zuciya, bugun jini da mutuwar zuciya. A Switzerland, bayanan magunguna na hukuma ba su bayar da wata alama ta wannan matsalar ba.

Sauran sakamakon da ba a so, kamar halayen gida a wurin yin allura ko lipodystrophy na cikin gida, ba su da yawa.

Marasa lafiya na iya fuskantar matsanancin rashin ƙarfi na hypoglycemia ko hyperglycemia (tare da kulawar da ba ta dace ba ko kuma rashin isasshen maganin). Duk yanayin yanayin biyu na iya lalata jikin mutum zuwa mafi girma ko mafi ƙaranci dangane da tsawon lokacin hypoglycemic ko hyperglycemic harin. Hyperglycemia mara kyau yana rinjayar yawancin gabobin jiki da tsarin jikin mutum, kuma yana haifar da rikice rikice a cikin dogon lokaci.

Cutar rashin lafiyan insulin matsala ce mai wuyar kamuwa da cutar insulin. A mafi yawan lokuta, rashin lafiyan yana faruwa ga wasu bangarorin na maganin, kuma ba insulin kanta ba. Kwayar cutar na iya faruwa nan da nan bayan allura. Waɗannan sun haɗa da itching, ƙonawa da jan launi na fata tare da kumburi. Wasu marasa lafiya na iya jin busasshen tari da alamomin asma.

A farkon maganin insulin, hangen nesa mai tsananin haske na iya faruwa, musamman idan matakin cutar ta glycemia yana daidaita al'ada. Tsoro na gani ba ya faruwa a tsakanin makonni 2-3.

Sashi da yawan abin sama da ya kamata

Sashi ya kamata a saita daban, kamar yadda yake da sauran insulins. A cikin nau'in 1 na ciwon sukari, ana inganta magani tare da insulin gajere. A cikin nau'in 2 na ciwon sukari na mellitus, ana iya amfani da miyagun ƙwayoyi shi kaɗai ko a haɗe tare da wakilai na hypoglycemic na baki.

Ba'a ba da shawarar yin amfani da miyagun ƙwayoyi a cikin mata masu juna biyu da kuma lokacin shaƙatawa ba, tunda ba a gudanar da nazarin aminci ba.

Haɗa kai

Tresiba insulin yana hulɗa da kwayoyi waɗanda ke shafar metabolism metabolism. Wasu na iya haifar da raguwa ko karuwa a cikin buƙatar insulin. Misalai sune hormones, masu hana beta, wasu magungunan psychotropic, kwayoyi masu juyayi, barasa, da sauran su.

Babban analogues na Tresiba:

Nazarin ra'ayi na ƙwararren likita da masu ciwon sukari.

Tresiba wani ingantaccen magani ne na maganin cututtukan cututtukan da ke aiki ko'ina cikin yini. Koyaya, kafin amfani, yakamata ka nemi likitanka, tunda maganin zai iya haifar da cututtukan jini.

Mikhail Mikhailovich, likitan diabetologist

Ni mai ciwon sukari na 1 Na dau magunguna tsawon shekaru. Ban ji wani mummunan illa ba. Wani lokacin yawan rashin lafiya yana faruwa, amma cub na sukari yadda yakamata ya dakatar dashi.

Farashi (a cikin Tarayyar Rasha)

Matsakaicin kullun na 30 U na insulin na wata-wata yakai kimanin 700 rubles na Rasha. Ana bada shawarar ƙarshe na ƙarshe don bincika dillalin dillali ko kantin magani a cikin kowane kantin magani.

Mahimmanci! Za'a iya ɗaukar miyagun ƙwayoyi bayan tattaunawa tare da likita. Ana ba da magani sosai gwargwadon abin da aka tsara.

Fasali da ka'idodin maganin

Babban sinadarin Tresib shine insulin degludec (degludec). Don haka, kamar Levemir, Lantus, Apidra da Novorapid, insulin na Tresib kwatankwacin hormone mutum ne.

Masana kimiyya na zamani sun sami damar ba da wannan magani ainihin abubuwan musamman. Wannan ya yiwu ne saboda yin amfani da kwayoyin halittar halittar halittar jikin kwayoyin halittar DNA wanda ya shafi kwayar cutar Saccharomyces da canje-canje a tsarin kwayoyin halittar dan adam na asali.

Babu cikakkun ƙuntatawa game da amfani da miyagun ƙwayoyi, insulin ya dace da duk marasa lafiya. Marasa lafiya da nau'in ciwon sukari na farko da na biyu zasu iya amfani dashi don maganin su na yau da kullun.

La'akari da ka'idodin tasirin insulin na Tresib a jiki, ya kamata a lura cewa zai kasance kamar haka:

1. Kwayoyin kwayoyi na miyagun ƙwayoyi suna haɗuwa cikin multicameras (manyan kwayoyi) kai tsaye bayan gudanarwar subcutaneous. Sakamakon wannan, an ƙirƙiri wurin saukar da insulin a cikin jiki,
2. ƙananan allurai na insulin sun rabu da hannun jari, wanda ke sa ya yiwu a sami sakamako mai tsawo.

Fa'idodin Treshiba

Insulin da ake la'akari dashi yana da fa'idodi masu yawa akan sauran insulins har ma analogues ɗin sa. Dangane da ƙididdigar likita na data kasance, insulin na Tresiba yana iya haifar da ƙaramar adadin hypoglycemia, ta hanyar, kuma sake dubawa sun faɗi iri ɗaya. Kari akan haka, idan kayi amfani dashi a sarari bisa umarnin da likitanka ya bayar, yawan faduwa cikin matakan sukari na jini ana hana su.

Zai dace a nuna cewa irin waɗannan fa'idodin na miyagun ƙwayoyi kuma ana lura dasu:

• kadan saɓani a cikin matakin glycemia a cikin sa'o'i 24. Ta wata hanyar, yayin yin jiyya tare da bushewar ruwa, sukari jini yana tsakanin matakan yau da kullun,
• saboda halayen magungunan Tresib, endocrinologist zai iya kafa ƙarin madaidaicin allurai ga kowane mai haƙuri.

A cikin lokacin da ake yin aikin insulin na maganin Tresib, mafi kyawun diyya ga cutar za a iya tsawaita, wanda zai taimaka wajen inganta rayuwar marasa lafiya. Kuma sake dubawa a kan wannan magani ba da damar yin shakkar babban tasirinsa.

Nazarin ne na marasa lafiya waɗanda suka riga amfani da miyagun ƙwayoyi, kuma kusan ba sa haɗuwa da sakamako masu illa.

Contraindications

Kamar kowane magani, insulin yana da bayyanannen contraindications. Don haka, ba za a iya amfani da wannan kayan aikin ba a irin wannan yanayi:

• Shekarun marasa haƙuri ƙasa da shekara 18
• ciki
• lactation (shayarwa),
• rashin haƙuri ga ɗayan kayan taimako na miyagun ƙwayoyi ko babban kayan aiki.

Bugu da kari, ba za a iya amfani da insulin don yin allura ba. Hanya guda daya da za'a iya bi wajen sarrafa Tresib insulin shine subcutaneous!

M halayen

Magungunan yana da nasa halayen, misali:

• rikice-rikice a cikin tsarin na rigakafi (cututtukan ciki, ƙwayar jijiyar jiki),
• matsaloli a cikin tafiyar matakai (na rayuwa),
• rikice-rikice a cikin fata da kasusuwa na kasusuwa (lipodystrophy),
• gaba daya cuta (edema).

Wadannan halayen na iya faruwa da wuya kuma ba a cikin duk marasa lafiya ba.

Mafi kyawun bayyanannu kuma akai-akai game da raunin da ya faru shine jan launi a wurin allurar.

Hanyar Saki

Ana samun wannan maganin ta hanyar katako, wanda za'a iya amfani dashi a cikin allunan sirinji na Novopen (Tresiba Penfill), mai sakewa.

Bugu da kari, yana yiwuwa a samar da Tresib a cikin nau'ikan nau'in sirinji na zubar da diski (Tresib FlexTouch), wanda ke ba da aikace-aikacen 1 kawai. Ya kamata a watsar da shi bayan gudanar da dukkan insulin.

Sashi na miyagun ƙwayoyi shine raka'a 200 ko 100 a cikin 3 ml.

Ka'idodi na asali don gabatarwar Tresib

Kamar yadda aka riga aka ambata, dole ne a gudanar da magungunan sau ɗaya a rana.

Maƙerin ya lura cewa allurar Tresib insulin ya kamata a yi a lokaci guda.

Idan mai haƙuri da ciwon sukari yayi amfani da shirye-shiryen insulin a karon farko, likita zai umurce shi da sashi na raka'a 10 sau ɗaya a cikin kowace awa 24.

Nan gaba, gwargwadon sakamakon auna sukari na jini a kan komai a ciki, ya zama dole don zakka adadin insulin na Tresib a cikin yanayin daidaiton mutum.

A cikin waɗannan yanayin inda aka gudanar da insulin na ɗan lokaci, likitancin endocrinologist zai ba da kwatancen magani wanda zai yi daidai da kashi na hormone na basal wanda aka yi amfani dashi a baya.

Wannan za a iya yin shi kawai a kan yanayin cewa hemoglobin na glycated yana a matakin da ba ƙasa da 8 ba, kuma ana sarrafa insulin basal sau ɗaya a rana.

Idan waɗannan sharuɗɗan ba a cika su da inganci ba, to a wannan yanayin ana iya buƙatar ƙaramin sashi na Tresib.

Likitocin suna da ra'ayin cewa zai yi amfani da mafi kyawun amfani da kananan kima. Wannan ya zama dole don dalilin cewa idan kun canja wurin kashi zuwa analogues, to koda za a buƙaci ƙaramin adadin ƙwayar don cimma glycemia na al'ada.

Binciken mai zuwa na yawan adadin insulin da ake buƙata ana iya yin shi sau 1 a mako. Titin yana kan matsakaiciyar sakamako ne na ma'aunin azumi biyu da suka gabata.

Kula! Ana iya amfani da Tresiba lafiya tare da:

Siffofin ajiya na magani

Ya kamata a adana Tresiba a cikin wuri mai sanyi a zazzabi na 2 zuwa 8. Yana iya zama firiji, amma a nesa daga injin daskarewa.

Karka taɓa daskarewa insulin!

Hanyar ajiya da aka nuna yana dacewa da insulin. Idan ya rigaya yana cikin alkalami mai siginar siginar da ake amfani dashi ko kuma wacce za'a iya amfani dashi, to a wannan yanayin, ana iya aiwatar da ajiya a ɗakin zafin jiki, wanda bai wuce digiri 30 ba. Rayuwar shiryayye a bayyane - watanni 2 (makonni 8).

Yana da matukar muhimmanci a kiyaye alkairin syringe daga hasken rana. Don yin wannan, yi amfani da hula na musamman wanda zai hana lalacewar insulin na Tresib.

Duk da gaskiyar cewa za'a iya siyan magungunan a cibiyar sadarwar magunguna ba tare da gabatar da takardar sayen magani ba, ba shi yiwuwa a rubuto shi da kanka!

Adadin kararraki

Idan akwai yawan insulin da ya wuce (wanda ba a yi rijista ba har yau), mara lafiya na iya taimakon kansa. Za a iya kawar da yawan zubar jini ta hanyar amfani da karamin adadin abubuwan da ke dauke da sukari:

• shayi mai dadi
• ruwan 'ya'yan itace
• cakulan marasa ciwon sukari.

Don hana hypoglycemia, yana da mahimmanci koyaushe ɗaukar kowane irin zaƙi tare da ku.