Abun da ya shafi da nau'in insulin "Apidra Solostar", farashin sa da sake dubawa game da masu ciwon sukari, analogues
Aikin magunguna | Kamar sauran nau'ikan insulin, Apidra yana haɓaka tasirin glucose ta hanta da ƙwayoyin tsoka, sauyawar glucose zuwa mai. Saboda wannan, ana rage sukarin jini. Hakanan, jiki yana haɓaka aikin furotin, ƙimar nauyi. Kwayoyin kwayoyi sun dan bambanta da insulin na mutum. Godiya ga wannan, allurar ta fara aiki da sauri. Mitar rashin lafiyar jiki ba ta ƙaruwa. |
Alamu don amfani | Nau'in 1 da nau'in ciwon sukari na 2 wanda ke buƙatar ramuwa tare da insulin. An wajabta Apidra don manya da yara, mata masu juna biyu, kusan dukkanin rukunan masu ciwon sukari. Don ƙarin bayani, duba labarin "Jiyya don Ciwon Cutar 1" ko "Insulin don Ciwon Cutar 2." Binciki anan kuma menene matakan insulin na jini suk fara allura. |
Lokacin yin allurar Apidra, kamar kowane nau'in insulin, kuna buƙatar bin abinci.
Contraindications | Allergic halayen insulin glulisin ko wasu abubuwan taimako a cikin kayan allura. Bai kamata a gudanar da maganin ba yayin abubuwan hailala (ƙwaƙwalwar jini). |
Umarni na musamman | Binciki labarin a kan abubuwan da ke shafar jijiyar insulin. Fahimci yadda cututtukan cututtuka, motsa jiki, yanayin, damuwa ke shafar. Karanta kuma yadda ake hada allurar insulin tare da barasa. Canja zuwa ga wani magani mai ƙarfi da sauri-Apidra ana aiwatar da shi sosai a ƙarƙashin kulawar likita. Saboda mummunan hypoglycemia na iya faruwa. Fara fara allurar ultrashort kafin abinci, ci gaba da nisantar abinci mai cutarwa. |
Sashi | Ba bu mai kyau amfani da tsari na yau da kullun na maganin insulin waɗanda ba su yin la’akari da halaye na mutum na masu ciwon suga ba. Ya kamata a zabi sashi na Apidra da sauran nau'ikan insulin gaba daya. Karanta daki-daki dalla-dalla labarai “Lissafin allurai na insulin azumi kafin abinci” da kuma “Gabatar da insulin: a ina kuma yadda ake farashi”. Ana amfani da miyagun ƙwayoyi ba bayan mintina 15 kafin cin abinci. |
Side effects | Mafi yawan abin da aka fi sani da haɗari sakamako ne ƙananan sukari na jini (hypoglycemia). Fahimci menene alamun wannan rikitarwa, yadda za a ba mai haƙuri kulawa ta gaggawa. Sauran matsalolinda zasu yiwu: redness, busa, da itching a wurin allurar. Lipodystrophy - saboda cin zarafin shawarwarin zuwa madadin wuraren allurar. Reactionsarancin rashin lafiyan halayen insulin na ultrashort suna da wuya. |
Yawancin masu ciwon sukari waɗanda ke yin allurar insulin suna ɗaukar abu mai wuya don kauce wa harin hypoglycemia. A zahiri, na iya tsayar da sukari na al'ada har ma da mummunan cutar kansa. Kuma har ma fiye da haka, tare da gwada da laushi kamar nau'in ciwon sukari 2. Babu buƙatar ƙara girman matakin glucose na jini zuwa inshorar kanka game da haɗarin hypoglycemia. Kalli bidiyon da Dr. Bernstein ya tattauna game da wannan batun tare da mahaifin yaro wanda ke da ciwon sukari na 1. Koyi yadda za a daidaita abinci mai gina jiki da allurai insulin.
Ciki da Shayarwa | Apidra ya dace don rama don yawan sukarin jini a cikin mata yayin daukar ciki. Ba shi da haɗari fiye da sauran nau'in insulin ultrashort, idan dai an ƙididdige yawan daidai. Gwada amfani da abincin da za ku yi ba tare da gabatarwar insulin cikin sauri ba. Karanta labaran "Cutar Cutar Ciki" da "Ciwon Cutar na ciki" don ƙarin bayani. |
Yin hulɗa tare da wasu magunguna | Magunguna waɗanda ke haɓaka aikin insulin kuma suna ƙara haɗarin hypoglycemia: ƙwayoyin ciwon sukari, masu hana ACE, abubuwan rashin biyayya, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates da sulfonamides. Magunguna waɗanda ke shafar sukari na jini sama: danazole, diazoxide, diuretics, isoniazid, abubuwan ƙwari na phenothiazine, somatropin, sympathomimetics, hormones na thyroid, maganin hana haihuwa, kariya na hanawa da maganin hana ƙwayoyin cuta. Yi magana da likitanka! |
Yawan abin sama da ya kamata | Mai tsananin rashin ƙarfi na iya faruwa, yana haifar da asarar hankali, lalata kwakwalwa mai ɗorewa, ko mutuwa. Tare da gagarumar yawan overdose na ultrashort insulin, mai haƙuri yana buƙatar asibiti mai gaggawa. Yayinda likitocin ke kan hanya, fara taimakawa a gida. Kara karantawa anan. |
Fom ɗin saki | Ana sayar da maganin allurar Apidra a cikin katako na milimita 3 na gilashi mai haske, mara launi, kowane ɗayan an sanya shi cikin alƙalin sirinji naSStar da za'a iya zubar dashi. Wadannan alkalami na kunshe cikin kwali na kwali na 5 inji mai kwakwalwa. |
Sharuɗɗan da yanayin ajiya | Dukkanin nau'ikan insulin da ake amfani da su don magance cututtukan ƙwayar cuta suna da rauni sosai kuma yana da sauƙi lalacewa. Sabili da haka, bincika ka'idodin adana kuma bi su a hankali. Rayuwar shiryayye na Apidra SoloStar shekaru 2 ne. |
Abun ciki | Abunda yake aiki shine insulin glulisin. Wadanda suka kware - metacresol, trometamol, sodium chloride, polysorbate 20, sodium hydroxide, hydrochloric acid mai karfi, ruwa don allura. |
Duba ƙasa don ƙarin bayani.
Apidra magani ne na wane mataki?
Mutane da yawa sun yi imani da cewa Apidra is insulin ne a takaice. A zahiri, magani ne na ultrashort. Bai kamata a rikita shi da insulin aiki ba, wanda yake gajarta ne. Bayan gudanarwa, Ultra-short-Apidra fara aiki da sauri fiye da gajeren shirye-shirye. Hakanan, ayyukanta ya daina aiki nan bada jimawa ba.
Musamman, gajeren nau'ikan insulin sun fara yin minti 20-30 bayan allurar, da kuma Apidra, Humalog da NovoRapid - bayan mintoci 10-15. Suna rage lokacin da mai ciwon sukari yake buƙatar jira kafin cin abinci. Bayanai masu nuni ne. Kowane mai haƙuri yana da nasa lokacin farawa da ƙarfin aikin injections na insulin. Baya ga miyagun ƙwayoyi da aka yi amfani da su, sun dogara da wurin allura, yawan kitse a jiki da sauran dalilai.
Da fatan za a lura cewa marasa lafiya da masu ciwon sukari waɗanda ke bin abincin ƙarancin carb, inje na gajeran insulin kafin abinci sun fi magungunan ultrashort. Gaskiyar ita ce abincin low-carb wanda ke da amfani ga masu ciwon sukari jiki yana ɗaukar hankali a hankali. Apidra na iya fara rage sukari da wuri fiye da furotin da aka ci yana narkewa kuma wani sashin shi ya koma glucose. Sakamakon bambanci tsakanin yawan aikin insulin da kuma rage cin abinci, sukarin jini zai iya yin kiba sosai, sannan kuma ya tashi a cikin ricochet. Yi la'akari da sauyawa daga insidul insidra zuwa ga ɗan gajeren magani, kamar Actrapid NM.
Menene tsawon lokacin allurar wannan ƙwayar?
Kowane allurar insidin insidra yana da inganci na tsawon awanni 4. Ragowar madawwami yana ɗaukar sa'o'i 5-6, amma ba mahimmanci. Babban matakin aiki yana cikin awanni 1-3. A sake auna sukari a kasa da awanni 4 bayan allurar ta. In ba haka ba, maganin da aka karba na hormone ba shi da isasshen lokacin yin aiki. Gwada kada ku ƙyale allurai biyu na cikin sauri a cikin jini a lokaci guda. A saboda wannan, injections na Apidra ya kamata a yi a cikin tazara na aƙalla awa 4.
Apidra ko NovoRapid: Wanne ya fi kyau?
Duk waɗannan nau'ikan insulin ultrashort suna da magoya baya da yawa. Suna kama da juna, duk da haka, a cikin kowane masu ciwon sukari, jikin yana amsa su ta hanyarsa. Wanne za a fara? Yanke shawara da kanku. A matsayinka na mai mulkin, marasa lafiya suna allurar insulin da aka basu kyauta.Idan wani magani ya dace da ku sosai, zauna a kansa. Canza wani nau'in insulin zuwa wani kawai idan ya zama dole.
Muna maimaita hakan ga marasa lafiya da ke da nau'in 1 da nau'in ciwon sukari na 2 waɗanda ke bin abincin karam, yana da kyau a yi amfani da gajeren insulin, maimakon Apidra, Humalog ko NovoRapid. Yi la'akari da canzawa zuwa ga wani ɗan gajeren magani, kamar Actrapid NM. Wataƙila wannan zai sa sukarin jininka kusa da al'ada, cire jikunansu.
6 ra'ayoyi akan Apidra
Ni mai shekaru 56 ne, tsayinsa ya zama santimita 170, nauyi kilo 100. Na kasance ina fama da ciwon sukari irin 2 kusan kusan shekaru 15. Na tsayar da nau'ikan insulin guda biyu - Insuman Bazal da Apidra. Ina kuma shan magunguna don hauhawar jini. Sashi na insulin: Insuman Bazal - da safe da maraice a KUDI 10, Apidra da safe a 8 SHAWARA, a cikin abincin rana da maraice a 10 SAUKI. Don wasu dalilai, da maraice kafin zuwa gado, sukari ya tashi zuwa 8-9, kodayake washegari yana da al'ada a cikin kewayon 4-6. Yaya za a daidaita adadin insulin? Inganta Apidra kafin abincin dare ko Insuman Bazal da safe? A baya, Na ɗauki allunan Amaryl kawai, amma sukari ya fara tashi zuwa 15, Dole ne in fara yin insulin. Na gode da amsar.
Yaya za a daidaita adadin insulin?
Kuna buƙatar bincika labaran a hankali kan lissafin sigogin dogon insulin shirye-shiryen insulin masu tsawo da sauri waɗanda aka liƙa akan wannan rukunin yanar gizon. An ambaci nassoshi a kansu a cikin labarin.
Insuman Bazal yana nufin magungunan matsakaici waɗanda aka fi maye gurbinsu da Levemir, Lantus ko Tresiba.
Shekaru 56, tsawo 170 cm, nauyi 100 kg. Na kasance ina fama da ciwon sukari irin 2 kusan kusan shekaru 15. Ina kuma shan magunguna don hauhawar jini.
Ina tsammanin ba ku yin la'akari da haɗarin mutuwa ko zama nakasassu sakamakon rikice-rikice a cikin shekaru masu zuwa. Wannan haɗarin yana da matukar girma. Bi da kanku da himma.
Sannu Ni ne shekara 67, tsayi 163 cm, nauyi 61 kg. Nau'in ciwon siga na 2, a cikin tsari mai tsanani, na dogon lokaci. Na rama tare da taimakon injections na insulin a cikin allurai tabbatacce - Lantus 22 raka'a, Apidra sau 3 a rana don raka'a 6. A cikin makon da ya gabata, sukari ya tashi zuwa 18-20, kuma a baya yawanci ya kasance har zuwa 10. Ba a canza sashin insulin ba ko abincin ya canza. Bayan allurar Apidra, matakan glucose na iya raguwa ko tashi. Duk wata alaƙa tsakanin abinci, insulin da matakan sukari sun ɓace. Menene zai iya zama dalilin? Na yi la'akari da raka'a gurasa. Ban shirya don canzawa zuwa abincin Dr. Bernstein ba, saboda rikicewar koda sun riga sun ci gaba. Ina fatan samun amsarku da wasu shawarwari.
A cikin makon da ya gabata, sukari ya tashi zuwa 18-20
Rashin hankalin hankali na iya haɓaka - ketoacidosis mai ciwon sukari ko ƙwaƙwalwar ƙwayar cutar hypoglycemic
Wannan kusan sau 2 ya fi na mutane lafiya, kuma ba maɓuɓɓugar ruwa ba
Bayan allurar Apidra, matakan glucose na iya raguwa ko tashi. Menene zai iya zama dalilin?
Me yasa allurar insulin ba ta rage sukari, duba anan - http://endocrin-patient.com/dozy-insulin-otvety/
Ban shirya don canzawa zuwa abincin Dr. Bernstein ba, saboda rikicewar koda sun riga sun ci gaba.
Akwai ƙorafi don ƙayyadadden ƙwayoyin ƙwayoyin cuta na duniyan 40-45 ml / min. Idan mai nuna alama yana ƙasa, to lallai ya makara da sauyawa zuwa tsarin abinci, jirgin kasan ya tafi. Kuma idan har yanzu ya kasance mafi girma, to, zaka iya kuma ya kamata ya tafi. Kuma da sauri, idan kuna son rayuwa. Duba http://endocrin-patient.com/diabet-nefropatiya/ domin cikakken bayani.
Sannu Ina da nau'in ciwon sukari na 1 tun Fabrairu 2018, Kolya Lantus sau 2 a rana da apidra don abinci. Kwanakin baya na ƙarshe, sukari ke ci gaba da kasancewa fiye da 10. Kuma suna fadowa da yawa, kawai cikin babbar insulin. Na kasance ina jin lokacin da suke da tsayi, amma yanzu wannan baya nan. Yau wani mafarki mai ban tsoro ne. Matsayin glucose daga 2 zuwa 16. Me yakamata ayi?
Fom ɗin saki
Maganin shine ruwa mai canza launin mara launi. Apidra shine analog na sake hadewar insulin na mutum, amma yana aiki da sauri kuma ba dadewa dangane da tasirin gaba daya. An gabatar da maganin a cikin kundin radar azaman insulin gajere.
Maganin yana samuwa a cikin katako don almarar maganin sirinji na musamman. A cikin katifa guda 3 na maganin, ba za a iya maye gurbinsa ba. Adana insulin a cikin firiji ba tare da daskarewa ba. Kafin allurar farko, fitar da alkalami a cikin 'yan awanni biyu domin magani ya zama da zazzabi a dakin.
Magunguna da magunguna
Babban tasirin magungunan shine daidaita tsarin aikin metabolism.Insulin yana rage yawan sukari, yana motsa sha'awa daga glucose ta kyallen tsinkaye - tsoka da mai.
Insulin kuma yana hana samar da glucose a cikin hanta, yana rage jinkirin proteolysis, lipolysis, da kuma haɓaka aikin furotin.
Nazarin asibiti na marasa lafiya da masu ciwon sukari sun nuna cewa injections na subcutaneous suna aiki da sauri, amma tasirin yana ƙasa da jimlar lokaci idan aka kwatanta da insulin ɗan adam ɗin mai narkewa.
Ana yin allura 2 mintuna kafin cin abinci - wannan yana tabbatar da daidaitaccen iko na glycemic. Lokacin gudanar da abinci bayan abinci bayan mintina 15, yana taimakawa sarrafa sukari na jini. Ana riƙe maganin a cikin jini na minti 98. Tsawon kwanaki 4 - 6.
Glulisin yana fitowa da sauri fiye da insulin mutum. Cire rabin rayuwar yayi mintina 42.
Manuniya da contraindications
Dangane da jagora ga miyagun ƙwayoyi, an wajabta shi ne kawai don ciwon sukari, hanya wanda ke buƙatar gabatarwar ƙwayar insulin. Mahimmancin contraindication shine yara a ƙarƙashin shekaru 6.
An bayar da maganin ne kawai bayan cikakken bincike na binciken haƙuri na haƙuri. Bukatar yin amfani da insulin, sashinta an yanke ta ne ta likitan likitan mata dangane da sakamakon binciken da alamun cutar sankara. Amfani da shi ba tare da kulawa ba zai iya haifar da rikitarwa.
Tabbataccen contraindication na miyagun ƙwayoyi shine hypoglycemia kuma rashin lafiyan abubuwan da ke ciki.
Yayin cikin lactation da ciki, za'a iya amfani da Apidra. Nazarin asibiti ya tabbatar da amincin miyagun ƙwayoyi, musamman idan aka tsaurara takaddun bin duk ka'idodi da mahaukacin endocrinologist ya kafa.
Side effects
Yawancin sakamako masu illa na yau da kullun sun haɗa da hypoglycemia. Hakan yana da alaƙa da yawan shan magunguna. Haɗarin rage yawan sukari mai yawa yana haɗuwa da rawar jiki, yawan damuwa da rauni. Mai tsananin tachycardia yana nuna tsananin yanayin.
A wurin allurar, halayen na iya faruwa - kumburi, rashes, redness. Dukkansu suna wucewa da kansu bayan makonni 2 na amfani. Cututtukan ƙwayar cuta masu saurin kima suna da ɗanɗano kuma sun zama alama ta buƙatar buƙatar maye gurbin magani na gaggawa.
Bayanin maganin yana nuna cewa cin zarafin hanyar yin allura da kuma halayen mutum na ƙasan ƙwaƙwalwar fata sau da yawa suna haifar da lipodystrophy.
Sashi da yawan abin sama da ya kamata
Dole ne a gudanar da magani na aƙalla na mintina 15 kafin cin abinci ko kuma bayansa. Ana amfani da "Apidra" a cikin dabaru daban-daban na ilimin insulin - tare da insulin na matsakaici ko magunguna na dogon lokaci. Hakanan ana wajabta maganin Apidra tare da magungunan baka wanda ke rage matakan sukari na jini. An zabi allurai ta hanyar endocrinologist.
Ana gudanar da apidra a ƙarƙashin subcutaneously ko ta hanyar ci gaba da jiko cikin ƙwayar subcutaneous tare da tsarin famfo.
Ana yin allura a ciki, kafadu, kwatangwalo. An ci gaba da jiko ne kawai a cikin ciki. Yana da mahimmanci don canza wurin allurar da jiko, suna canzawa tare da kowane gabatarwar mai zuwa. Yawan sha, lokacin farawa da tsawon lokaci yana shafar:
- wurin allura
- aiki na jiki
- fasalin jikin mutum
- lokacin gudanar da mulki, da sauransu.
Lokacin da aka shiga cikin ciki, sha yana da sauri.
Don hana samfurin shigowa da jini, dole ne a bi duk matakan da likita kwatankwacinsu suka bayyana, yana koyar da masu ciwon sukari dabarar yin allura. Bayan allura, an haramta yin tausa wannan wurin.
Apidra yana halatta gaurayawa tare da insulin isophane. Lokacin amfani da famfo, an haramta hadawa.
Tare da yawan wuce haddi na insulin a cikin jiki, yawan haɗarin haɗarin hypoglycemia yana ƙaruwa. Tsarin sassauci ana dakatar da sauri ta hanyar ɗaukar samfuran glucose ko sukari, yanki na sukari. A wannan batun, masu ciwon sukari ya kamata koyaushe suna da sukari ko wani abu mai daɗi tare da carbohydrates mai sauƙi, ruwan 'ya'yan itace mai laushi, da dai sauransu.
Kyakkyawan tsari, wanda aka nuna ta birkicewa, rikicewar jijiyoyin jiki, coma za a iya dakatar da shi ta hanyar gudanar da glucagon intramuscularly ko subcutaneously, shima babban bayani na dextrose. Kwararru ne kawai yakamata suyi. Lokacin da aka dawo da hankali, kuna buƙatar cin wani abu tare da carbohydrates mai sauƙi don hana sake dawowa daga harin, wanda zai iya sake farawa nan da nan bayan jin daɗi. Hakanan, mai haƙuri ya zauna a asibiti na ɗan wani lokaci, don likitan ya iya lura da kula da mai haƙuri koyaushe.
Haɗa kai
A kan nazarin hulɗa da ilimin magunguna don insulin "Apidra" ba a gudanar da shi ba. Dangane da ilimin da ake samu na analogues, haɓaka mahimmancin hulɗa a cikin asibiti ya zama mai yiwuwa ne a taƙaice. Wasu abubuwa a cikin abubuwan da ke tattare da kwayoyi na iya shafar ayyukan metabolism, sabili da haka, wani lokaci ana buƙatar daidaita sashin insulin.
Wakilai masu zuwa suna inganta tasirin cutar ta Apidra:
- hypoglycemic magunguna don baka,
- zaren wuta
- rashin biyayya
- mai kyalli
- skwarin
- asfirin
- maganin sulfonamide antimicrobial.
Rage tasirin hypoglycemic na iya:
- danazol
- girma hormone,
- masu hana masu kariya
- estrogens
- hodar iblis,
- tausayawa.
Barasa, salts na litium, beta-blockers, clonidine na iya raunana tasiri na miyagun ƙwayoyi, yana haifar da harin hypoglycemia da hyperglycemia mai zuwa.
Ana gabatar da abubuwan maye da analogues na miyagun ƙwayoyi a cikin tebur.
Sunan insulin | Kudin, masana'anta | Siffofi / Abubuwan da ke Aiki |
Humalog | Daga 1600 zuwa 2200 rub., Faransa | Babban bangaren - insulin lispro, yana daidaita ayyukan tafiyar glucose da kuma haɓaka hadaddun furotin, ana samarwa cikin dakatarwa da mafita. |
"Humulin NPH" | Daga 150 zuwa 1300 rub., Switzerland | Bangaren da yake aiki shine insulin isophan, wanda ke taimakawa sosai don sarrafa matakin cutar ta glycemia, ana samunsu a cikin abubuwan kwantar da hankali na sirinji, kuma an yarda dashi yayin daukar ciki. Zai iya haifar da itching na gaba daya. |
Aiki | Daga 350 zuwa 1200 rubles., Denmark | An wajabta insulin gajeriyar aiki yayin da wasu kwayoyi ba su taimaka don cimma sakamakon da ake tsammanin ba. Yana kunna hanyoyin kwantar da hankali kuma an sake shi cikin bayani. Babban haɗarin lipodystrophy, ya wajaba don daidaita sashi yayin ƙoƙarin jiki. |
Magungunan "Apidra Solostar" Na dage don 'yan mintoci kaɗan kafin cin abinci. Aikin yana da sauri sosai, ya dace da ni. Hakanan dacewa don amfani a cikin alkalannin sirinji. Lokacin amfani da sakamako masu illa ba a bayyana koda sau ɗaya.
Ba da daɗewa ba an tura ni zuwa cikin magungunan Apidra. Yana aiki sosai kuma yana sauri, glucose al'ada ce. Ina amfani da insulin kafin cin abinci, ban lura da wani rashin jin daɗi a wurin allurar ba. Na kasance ina yin wannan insulin tsawon watanni 6, Na gamsu da maganin.
Alexandra, 65
Packageaya daga cikin kunshin ɗaya tare da sirinji na musamman na Apidra yana da kusan 2100 rubles. Shiryayyar rayuwar ƙwayar cuta a cikin hanyar rufewa ita ce shekaru 2 a cikin firiji. Don rage yiwuwar lipodystrophy, magani yana sanyaya zuwa zazzabi a ɗakin kafin amfani. Kuna iya adana magunguna na buɗe don makonni 4 a cikin wurin da rana ba ta fadi da zazzabi wanda bai wuce digiri 25 ba.
Kammalawa
Endocrinologists suna da ra'ayin cewa ciwon sukari ba wai kawai ilimin cuta ba ne, amma hanya ce ta rayuwa. Ya ƙunshi mahimmancin amfani da kwayoyi, bin ka'idodi na abinci. Kulawa da hankali ga duk shawarwari da zaɓin madaidaiciyar sashi shine mabuɗin babban ingancin rayuwa, koda da irin wannan cutar. Apidra yana taimaka wa masu ciwon sukari da yawa su ji daɗi kuma su manta game da ɗimbin sukari.
Tasirin warkewar cutar
Babban mahimmancin aikin Apidra shine ka'idojin inganci na glucose metabolism a cikin jini, insulin ya sami damar rage yawan sukari, don haka yana ƙarfafa shayarwa ta hanyar tsinkaye na waje:
Insulin yana hana samar da glucose a cikin hanta mai haƙuri, adipocyte lipolysis, proteolysis, da kuma haɓakar haɓakar furotin.
A cikin binciken da aka gudanar kan mutane masu lafiya da marasa lafiya da ke fama da cutar sankara, an gano cewa gudanar da mulki na glulisin yana bayar da sakamako mai sauri, amma tare da gajeren lokaci, idan aka kwatanta da insulin mutum na narkewa.
Tare da gudanarwa na ƙwayar subcutaneous na miyagun ƙwayoyi, tasirin hypoglycemic zai faru a cikin mintuna 10 zuwa 20, tare da injections na ciki wannan tasirin yana daidai da ƙarfi ga aikin insulin na mutum. Apungiyar Apidra tana da halin aiki na rashin ƙarfi, wanda ya yi daidai da na insulin ɗan adam mai narkewa.
Ana gudanar da insulin na Apidra 2 mintuna kafin abincin da aka yi niyya, wanda ke ba da izinin sarrafawar glycemic na al'ada na postprandial, mai kama da insulin na mutum, wanda ana gudanar da mintina 30 kafin abinci. Ya kamata a lura cewa irin wannan kulawa shine mafi kyau.
Idan ana gudanar da glulisin mintina 15 bayan cin abinci, zai iya samun iko a kan yawan tattarawar sukari na jini, wanda ya yi daidai da insulin na mutum wanda aka ba shi mintina 2 kafin cin abinci.
Insulin zai tsaya a cikin jini zuwa minti 98.
Magidodi na yawan abin sama da ya kamata da kuma cutarwa
Mafi sau da yawa, mai haƙuri da ciwon sukari na iya haɓaka irin wannan sakamako mara amfani kamar hypoglycemia.
A wasu halayen, miyagun ƙwayoyi suna haifar da wucewar fata da kumburi a wurin allurar.
Wasu lokuta tambaya ce ta lipodystrophy a cikin ciwon sukari na mellitus, idan mai haƙuri bai bi shawarar ba a madadin wuraren allurar insulin.
Sauran halayen rashin lafiyan halayen sun hada da:
- choking, urticaria, rashin lafiyan cututtukan fata (sau da yawa),
- kirji (kirji).
Tare da bayyanar da halayen halayen ƙwayar cuta, akwai haɗari ga rayuwar mai haƙuri. A saboda wannan dalili, yana da mahimmanci ku kula da lafiyarku kuma ku saurari abubuwan damuwarta.
Lokacin da yawan abin sama da ya faru, mai haƙuri yana haɓaka ƙwanƙwasa ƙwayar cuta mai ƙarfi a hankali. A wannan yanayin, an nuna magani:
- m hypoglycemia - amfanin abinci da ke da sukari (a cikin masu ciwon sukari ya kamata su kasance tare da su koyaushe)
- tsananin hypoglycemia tare da asarar hankali - tsayawa ana aiwatar da shi ta hanyar gudanar da 1 mil na glucagon subcutaneously ko intramuscularly, ana iya gudanar da glucose a cikin jijiya (idan mai haƙuri bai amsa glucagon ba).
Da zaran mara lafiya ya dawo cikin hayyacinsa, to lallai yana bukatar cin abinci mai yawa na carbohydrates.
Sakamakon cututtukan hypoglycemia ko hyperglycemia, akwai haɗarin ƙarancin mai haƙuri na mayar da hankali, canza saurin psychomotor. Wannan yana haifar da wata barazana yayin tuki motocin ko wasu hanyoyin.
Ya kamata kulawa ta musamman ga masu ciwon sukari da ke da ikon ragewa ko kuma ba su da cikakkiyar damar sanin alamun cutar rashin ƙarfi. Hakanan yana da mahimmanci ga yawan lokutan yawan sukari mai narkewa.
Irin waɗannan marasa lafiya ya kamata su yanke shawara game da yiwuwar sarrafa abubuwan hawa da injuna daban-daban.
Sauran shawarwari
Tare da amfani da insulin na Apidra SoloStar na layi tare da wasu kwayoyi, ana iya ƙaruwa ko raguwa cikin tsinkayar ci gaban hauhawar jini, al'ada ce a haɗa da irin waɗannan hanyoyin:
- na baki hypoglycemic,
- ACE masu hanawa
- zaren wuta
- Yin watsi da su,
- MAO masu hanawa
- Fluoxetine,
- Pentoxifylline
- salicylates,
- Propoxyphene,
- maganin antimicrobials na sulfonamide.
Tasirin hypoglycemic zai iya raguwa nan da nan sau da yawa idan an gudanar da insulin glulisin tare da kwayoyi: diuretics, abubuwan da ke haifar da kwayoyin halittar sitot, cututtukan thyroid, inhibitors, antipsychotropic, glucocorticosteroids, Isoniazid, Phenothiazine, Somatropin, sympathomimetics.
Magungunan Pentamidine kusan koyaushe yana da hypoglycemia da hyperglycemia. Ethanol, salts lithium, beta-blockers, miyagun ƙwayoyi Clonidine na iya yin ƙarfin ƙarfi kuma ya ɗan raunana tasirin hypoglycemic.
Idan ya zama dole don canja wurin masu ciwon sukari zuwa wani nau'in insulin ko wani nau'in magani, tsananin kulawa daga likitan halartar yana da mahimmanci. Lokacin da aka yi amfani da insulin na insulin da yawa ko kuma mara lafiya ya yanke shawarar yanke magani, wannan zai haifar da ci gaban:
Duk waɗannan yanayin suna haifar da haɗari ga rayuwar mai haƙuri.
Idan akwai canji a cikin aikin motsa jiki na al'ada, adadi da ingancin abinci da aka ƙone, ana iya buƙatar daidaita sashin insidin insidra. Aiki na jiki wanda ke faruwa nan da nan bayan cin abinci na iya ƙara yawan yiwuwar ƙin jini.
Marasa lafiya tare da ciwon sukari ya canza bukatar yin insulin idan yana da yawan wahalar rai ko kuma cututtuka masu rikitarwa. An tabbatar da wannan tsarin ta hanyar sake dubawa, duka likitoci da marasa lafiya.
Ana buƙatar insulin na Apidra a cikin wuri mai duhu, wanda dole ne a kiyaye shi daga yara har tsawon shekaru 2. Mafi kyawun zazzabi don adana maganin shine daga digiri 2 zuwa 8, haramun ne a daskare insulin!
Bayan fara amfani da shi, ana ajiye katako a cikin zafin jiki wanda bai wuce digiri 25 ba, sun dace don amfani da su na tsawon wata guda.
Bayanin insulin na Apidra an ba da shi a cikin bidiyon a cikin wannan labarin.
Apidra, umarnin don amfani
Insulin Apidra SoloStar an yi shi ne don gudanarwar sc, wanda za'ayi a ɗan lokaci kaɗan (minti 0-15) ko kuma nan da nan bayan cin abinci.
Ya kamata a yi amfani da wannan magani a cikin hanyoyin maganin warkewa, gami da rabawa tsawan insulin (wataƙila daidai) ko matsakaici tsawo inganci, kuma a layi daya tare da na baka hypoglycemic kwayoyi aiki.
An tsara tsarin aikin allura na Apidra da akayi daban-daban.
Gabatar da Apidra SoloStar ana aiwatar dashi ta allurar sc, ko taci gaba jikoan yi shi da kitsen mai cutarwa tsarin famfo.
Ana gudanar da allurar sc all a cikin kafada, bangon ciki (gaban) ko cinya. Ana yin jiko a cikin kitsen subcutaneous a cikin yankin bango na ciki (gaban). Wajibi ne a sauya wuraren da ke ƙarƙashin ikon yin cinya (cinya, bango na ciki, kafada) tare da kowane allura mai zuwa. Don sauri sha kuma tsawon lokaci na bayyanuwa da miyagun ƙwayoyi na iya rinjayar abubuwan da aka yi, wasu canji, da kuma shafin gudanarwa. Allura da bangon ciki na sauri shaidan aka kwatanta da gabatarwar zuwa cinya ko kafada.
Lokacin gudanar da allura, duk matakan da suka dace dole ne a kiyaye su don fitar da shigarwar miyagun ƙwayoyi kai tsaye magudanar jini . Bayan allura an haramta tausaa bangarorin gabatarwa. Dukkanin marasa lafiya da ke amfani da Apidra SoloStar ana buƙatar su yi shawara kan dabarun gudanarwa na kwarai. insulin.
An yarda da haɗaɗa Apidra SoloStar tare da insulin mutum na isophane. A kan aiwatar da hada waɗannan magungunan, dole ne a shigar da Apidra cikin sirinji da farko. Ya kamata a gudanar da aikin SC nan da nan bayan tsarin hada abubuwa. Ba a aiwatar da allurar rigakafin magunguna ba.
Idan ya cancanta, za'a iya cire maganin maganin daga cikin katun da aka haɗa a cikin alkairin sirinji kuma anyi amfani dashi a ciki na'urar yin famfotsara don ci gaba sc jiko. Game da gabatarwar Apidra SoloStar tare da tsarin famfo, ba a yarda da hadawa da wasu magunguna ba.
Lokacin amfani jiko sa da tanki amfani da Apidra, ya kamata a canza su aƙalla sa'o'i 48 daga baya don bin duk ka'idodi. Waɗannan shawarwarin na iya bambanta da waɗanda aka ayyana a cikin umarnin guud don na'urorin yin famfoduk da haka, aiwatar da kisa yana da matukar muhimmanci ga halayen da suka dace jikoda hana samuwar mummunan sakamako mara kyau.
Marasa lafiya da ke ci gaba da rikicewar apidra s / d jiko ya kamata su sami madadin tsarin allura don gudanar da maganin, kuma a horar da su a cikin hanyoyin da ake amfani da su (idan ana lalacewa.na'urar yin famfo).
A lokacin ci gaba jiko Apidra, malfunction na jiko an saita famfo, cin zarafin aikinsa, da kuma kurakurai a cikin magudi tare da su, na iya zama cikin hanzari ya zama sanadin hawan jini, mai fama da ciwon sukari ketoacidosis da ketosis. Game da gano wadannan alamun, yana da gaggawa a tabbatar da dalilin ci gaban su kuma cire shi.
Amfani da SoloStar Syringe Pen tare da Apidra
Kafin amfani na farko, dole ne a riƙe alkairin sirinjin SoloStar na awanni 1-2 a zazzabi a daki.
Nan da nan kafin amfani da alkairin sirinji, yakamata a bincika kwalliyar da aka sanya a ciki, abubuwan da yakamata su kasance mara launi, mkuma ba sun hada da bayyane ba m batun kasashen waje (tunatar da daidaito ruwa).
Abubuwan SoloStar Syringe da aka yi amfani da shi baza'a iya sake amfani dasu ba kuma dole ne a zubar dasu.
Don hana yiwuwar kamuwa da cutaMutun ɗaya ne kawai zai iya amfani da alkalami ɗaya ɗaya ba tare da canja wurin shi ga wani mutum ba.
Tare da kowane sabon amfani da alkairin sirinji, a haɗa da sabon allura a kai (ya haɗa ta da SoloStar) ka riƙe gwajin aminci.
Lokacin kulawa da allura, yakamata a kula sosai raunin da ya faruda kuma dama na ciwon maɗamfari canja wuri.
Ya kamata a guji amfani da almarar sirinji idan sun lalace, haka kuma a yanayin rashin tabbas a aikinsu da kyau.
Ya zama koyaushe ya zama dole a sami alkalami mai sifiɗa na hannun jari, idan akwai asara ko lalacewar farkon.
Dole a kiyaye alkairin sirinji daga datti da ƙura, yana halatta a goge sassan jikinta rigar rigar. Ba'a ba da shawarar a nutsar da alkairin sirinji cikin ruwa, yin wankako man shafawasaboda wannan na iya haifar da lalacewar shi.
Mai aiki sirinji mai sulɓi SoloStar amintacce a cikin aiki, daban ainihin dosing na maganin kuma yana buƙatar kulawa da hankali. Lokacin aiwatar da dukkan jan kafa ta sirinji, ya wajaba don guje wa duk wani yanayi da zai haifar da lalacewarsa. Idan akwai wani tabbaci game da rashin aiki, yi amfani da alkalami na dabam.
Nan da nan kafin allurar, tabbata cewa shawarar shawarar insulinta hanyar bincika lakabin a kan alamar sirinji. Bayan cire hula daga sirinji, kuna buƙatar dubawa na gani abin da ke ciki, bayan wanda shigar allura. An yarda kawai mara launi, mkama da ruwa mai daidaituwa ba tare da wani ba kasashen waje daskararru mafita insulin. Don kowane allurar da ta biyo baya, ya kamata a yi amfani da sabon allura, wanda zai zama bakararre kuma ya dace da alkalami.
Kafin allurar, tabbatar gwajin aminci, bincika aikin da ya dace na alkairin sirinji da allura da aka sanya akan sa, sannan kuma cire shi daga maganin iska (idan akwai).
A saboda wannan, lokacin da aka cire ƙofofin ciki da na ciki na allura, ana auna kashi na maganin daidai yake da 2 PIECES. Yana nuna allura na alkairin madaidaiciya, a hankali, a matatar da katun a yatsan ku, kuna ƙoƙarin canza komai iska zuwa allurar da aka shigar. Latsa maɓallin da aka yi niyya don gudanar da magani. Idan ya bayyana a saman allura, zamu iya ɗauka cewa alkairin sirinji yana aiki kamar yadda aka zata. Idan hakan ba ta faruwa ba, maimaita wannan amfani na sama har sai an sami sakamako da ake so.
Bayan gwajiDon aminci, taga allurai na alkairin ya kamata ya nuna darajar “0”, bayan haka zaku iya saita sigar da ake buƙata. Ya kamata a auna yawan maganin da aka sarrafa tare da daidaito na 1 UNIT, a cikin adadin sashi daga 1 UNIT (mafi ƙaranci) zuwa 80 UNITS (mafi yawa). Idan ya cancanta, ana yin kashi daya akan raka'a 80 a cikin alluran biyu ko fiye.
Lokacin yin allura, dole a saka allura da aka ɗora akan alƙalin syringekarkashin fata. Maballin alkalami na syringe wanda aka shirya don gabatarwar mafita dole ne a matse shi sosai kuma ya kasance a cikin wannan matsayi na tsawan 10 har sai an cire allurar, wanda ke tabbatar da cikakken ikon sarrafa maganin.
Bayan allurar, ya kamata a cire allura kuma a watsar da shi. Ta wannan hanyar, ana ba da gargaɗin ajiya. cututtukada / ko gurbata yanayialkalanin sirinji, da kuma yalwar miyagun ƙwayoyi da iska suna shiga cikin kicin. Bayan cire allura da aka yi amfani da shi, yakamata a rufe alkairin satarwar SoloStar tare da hula.
Lokacin cirewa da zubar da allura, ya zama dole a bi shi ta hanyar dokoki da hanyoyi na musamman (alal misali, dabarar shigar da madaukin allura da hannu ɗaya), don rage haɗarin hatsarorikazalika da hanawa kamuwa da cuta.
Yawan abin sama da ya kamata
Game da wuce kima mulki insulinna iya faruwa yawan haila.
Tare da haske yawan haila, za a iya dakatar da bayyanannun bayyanar ta cin abinci sukari dauke dana samfuroriko glucose. Marasa lafiya tare da ciwon sukariko da yaushe bayar da shawarar dauke kuki, alewaguda sukariko ruwan 'ya'yan itace mai zaki.
Bayyanar cututtuka yawan haila(gami daraunin jijiyoyin jiki, katsewa, asarar sani,) Dole ne a dakatar da mutum na biyu (na musamman) da ke da horo ta hanyar yin allura / m ko s / c ko a / gabatarwar mafita. Idan aikace-aikace glucagonbai ba da sakamako ba na mintina 10-15, canza zuwa gwamnatin iv dextrose.
Haƙuri wanda ya zo wurin sanibayar da shawarar cin abinci mai arziki carbohydratestsaya a kan ƙarshe don maimaitawa yawan haila.
Don sanin abubuwan da ke haifar da mai ƙarfi yawan hailada kuma rigakafin ci gabanta a nan gaba, wajibi ne a lura da mai haƙuri a ciki asibiti.
Umarni na musamman
Alƙawarin haƙuri insulinwani masana'antar shuka ko madadin insulin yakamata a gudanar da shi karkashin tsananin sanya ido na ma’aikatan lafiya, dangane da yiwuwar sauya tsarin allurar, saboda karkacewar insulin taronau'insa (insulin isophane, mai narkewada sauransu), tsari (mutum, dabba) da / ko hanyar samarwa. Hakanan ana iya canza canje-canje a layi daya hypoglycemicfar tare da baka siffofin. Rage magani ko rashin isasshen magani insulinmusamman a cikin marasa lafiya tare da cutar samarina iya haifar da ciwon sukari ketoacidosisda hawan jiniwakiltar hatsari ga rayuwar mai haƙuri.
Rashin lokaci na ci gaba yawan hailasaboda yawan samuwar tasirin insulin amfani da kwayoyi, kuma saboda wannan, yana iya canzawa yayin daidaita tsarin kulawa da warkewa. A cikin yanayi canza yanayin halitta yawan hailako sanya su mara karfi da aka ambata, hada da: ƙaruwadogon kasancewa ciwon sukari mellituskasancewar mai ciwon sukari mai ciwon sukaricanza kanta insulinshan wasu ƙwayoyi (misali.masu hana beta).
Daidaitawa insulindosages na iya zama dole lokacin da kara haƙuri aiki na jiki ko canza tsarin abincinku na yau da kullun. Yi motsa jiki daidai bayan cin abinci yana kara haɗarin ku yawan haila. Lokacin amfani da sauri insulin ci gaba yawan hailatafiya da sauri.
Ba a haɗa shi ba hyper- ko hypoglycemicbayyane na iya haifar da ci gaba, asarar hankali, ko ma mutuwa.
jikin mutum da insulin glulisin dangane da tayin/tayinci gaba, hanya ciki, aikin patrimonial da postnatalci gaba.
Sanya Apidra mai cikimata su yi hankali da kulawa tare da wajabta na ci gaba da aikin plasma matakin glucose da sarrafawa.
Cikimata da ciwon sukari ya kamata sanin yiwuwar raguwar buƙatu na insulinko'ina Na watanni uku na cikikaruwa a Na biyu da na ukukazalika da saurin raguwa bayan.
Zabi insulin glulisin tare da madara na mahaifiyar mai reno ba a kafa. Tare da yin amfani da shi a lokacin, yana iya zama dole a daidaita tsarin allurai.
Short-aiki insulin mutum.
Shiri: APIDRA ®
Abunda yake aiki: insulin glulisine
Lambar ATX: A10AB06
KFG: insulin ɗan adam-gajere
Reg. lamba: LS-002064
Ranar rajista: 10/06/06
Mai mallaka reg. acc.: AVENTIS PHARMA Deutschland GmbH
MAGANAR CIKIN SAURARA, CIGABA DA AIKATA
Magani don sc gwamnati m, launi ko kusan launi.
Fitowa: m-cresol, trometamol, sodium chloride, polysorbate 20, sodium hydroxide, acid hydrorated, ruwa d / i.
3 ml - gilashin gilashin launuka marasa launi (1) - Tsarin katun katako na OptiClick (5) - fakitoci na kwali.
3 ml - gilashin gilashin launuka marasa launi (5) - kayan kwalliyar tantanin halitta (1) - fakitoci na kwali.
Bayanin miyagun ƙwayoyi ya dogara ne da umarnin hukuma da aka tabbatar don amfani.
Insulin glulisin wani abu ne wanda yake cike da insulin na mutum, wanda yake daidai gwargwado ga mai narkewa daga jikin mutum, amma yana farawa da sauri kuma yana da takaitaccen aiki.
Babban mahimmancin aikin insulin da analogues na insulin, gami da insulin glulisin, shine ƙa'idar aiki na glucose. Insulin yana rage yawan glucose a cikin jini, yana karfafa shaye-shayen glucose ta kasusuwa na waje, musamman tsokoki na kasusuwa da tsotse nama, da kuma hana samuwar glucose a cikin hanta. Insulin yana hana lipolysis a cikin adipocytes, proteolysis kuma yana kara haɓakar furotin. Nazarin da aka gudanar a cikin masu ba da agaji da lafiya da marasa lafiya tare da masu ciwon sukari mellitus sun nuna cewa tare da sc አስተዳደር insulin glulisin ya fara aiki da sauri kuma yana da ɗan gajeren lokacin aiki fiye da insulin ɗan adam mai narkewa. Tare da gudanarwa na subcutaneous, tasirin hypoglycemic yana haɓaka bayan minti 10-20. Tare da gudanarwa na iv, tasirin hypoglycemic na insulin glulisin da insulin ɗan adam yana daidai da ƙarfi. Unitaya daga cikin yanki na insulin glulisin yana da aiki iri ɗaya na aikin hypoglycemic kamar yanki ɗaya na insulin ɗan adam mai narkewa.
A cikin wani rukuni na yi nazari a cikin marasa lafiya da nau'in ciwon sukari na 1 na sukari, an kimanta bayanan hypoglycemic na insulin glulisin da insulin ɗan adam mai narkewa, ana sarrafawa s.c. a cikin kashi 0.15 IU / kg a lokuta daban-daban dangane da daidaitaccen abinci na mintina 15.
Sakamakon binciken ya nuna cewa glulisin insulin, wanda aka gudanar da mintina 2 kafin cin abinci, ya samar da iko iri guda na glucose bayan abinci kamar yadda insulin dan adam mai narkewa, ana gudanar da mintina 30 kafin cin abinci. Lokacin da aka gudanar da mintina 2 kafin cin abinci, insulin glulisin ya samar da mafi kyawun sarrafa glucose a bayan cin abinci fiye da insulin ɗan adam mai narkewa mintina 2 kafin cin abinci.Glulisin insulin, ana gudanar da shi na mintina 15 bayan fara cin abincin, ya ba da izinin sarrafa glucose iri ɗaya kamar yadda mai narkewa na ɗan adam wanda ke gudana a mintina 2 kafin cin abincin.
Wani rukuni da na yi nazari tare da insulin glulisin, lispro insulin da insulin mutum a cikin rukunin marasa lafiya ya nuna cewa a cikin wadannan marasa lafiyar, insulin glulisin yana ba da lokaci don ci gaban tasirin. A cikin wannan binciken, lokacin da ya isa zuwa 20% na jimlar AUC shine 114 min don insulin glulisin, 121 min don insulin lispro da 150 min don insulin mutum, kuma AUC 0-2 h, shima yana nuna farkon aikin hypoglycemic, shine 427 mg hkg -1 don insulin glulisin, 354 mg / kg -1 don insulin lispro, kuma 197 mg / kg -1 don insulin mutum.
Type 1 ciwon sukari
A cikin gwajin asibiti na 26-mako na kashi na III, wanda aka kwatanta insulin glulisin tare da insulin lispro, ana gudanar da sc jim kaɗan kafin abinci (0-15 mintuna), marasa lafiya waɗanda ke da nau'in ciwon sukari na 1 na mellitus ta yin amfani da insulin glargine, insulin glulisin kamar basal ya kasance daidai da insulin lispro dangane da sarrafa glucose, wanda aka kimanta da canji a cikin taro na haemoglobin (HbA 1C) a ƙarshen nazarin idan aka kwatanta da sakamakon. Akwai abubuwa masu kwantar da hankali a cikin jini wanda aka ƙaddara ta hanyar kulawa da kai. Tare da gudanar da insulin glulisin, ya bambanta da insulin jiyya tare da lispro, ba a buƙatar karuwa da kashi na insulin basal.
Gwajin asibiti na 12-mako na III wanda aka gudanar a cikin marasa lafiya da masu ciwon sukari na 1 wanda suka karɓi insulin glargine a matsayin maganin basal ya nuna cewa ingancin aikin insulin glulisin nan da nan bayan abinci ya kasance daidai da insulin glulisin nan da nan kafin abinci (na 0 -15 min) ko narkewar mutum (30-45 min kafin abinci).
Daga cikin marasa lafiyar da suka yi laƙabin binciken, a cikin rukuni na marasa lafiya waɗanda suka karɓi insulin glulisin kafin abinci, an lura da raguwa mai girma a cikin HbA 1C idan aka kwatanta da rukunin marasa lafiyar da suka sami insulin ɗan adam mai narkewa.
Type 2 ciwon sukari
Gwajin asibiti na makonni 26 na kashi na III wanda ya biyo bayan makonni 26 a cikin yanayin binciken aminci idan aka kwatanta insulin glulisin (mintina 0-15 kafin abinci) tare da insulin mutum mai narkewa (mintuna 30-45 kafin abinci), wanda aka gudanar dashi s / ga marasa lafiya masu fama da ciwon sukari na 2 na sukari, ban da amfani da isofan-insulin a matsayin basal. Matsakaicin matsakaiciyar ƙoshin jikin mutum shine 34.55 kg / m 2. Insulin glulisin ya nuna kansa a matsayin wanda yake daidai da insulin ɗan adam mai narkewa dangane da canje-canje a cikin ƙwayoyin HbA 1C bayan watanni 6 na magani idan aka kwatanta da sakamakon (-0.46% don insulin glulisin da -0.30% don insulin ɗan adam mai narkewa, p = 0.0029) da kuma bayan watanni 12 na magani idan aka kwatanta tare da sakamako (-0.23% don glulisin insulin da -0.13% don insulin ɗan adam mai narkewa, bambanci ba shi da mahimmanci). A cikin wannan binciken, yawancin marasa lafiya (79%) sun haɗu da insulin-ɗan gajeran aiki da isofan-insulin nan da nan kafin allura. Marasa 58 a lokacin bazuwar sun yi amfani da magungunan maganin hypoglycemic na baki da karɓar umarni don ci gaba da yin amfani da su a cikin kashi ɗaya.
Nasihu da jinsi
A cikin gwajin asibiti da aka sarrafa a cikin manya, bambance-bambance a cikin aminci da tasiri na insulin glulisin ba a nuna su ba a cikin binciken ƙungiyoyi da aka gano ta hanyar jinsi da jinsi
A cikin insulin glulisine, maye gurbin amino acid asparagine na ɗan adam insulin a matsayin B3 tare da lysine da lysine a matsayi B29 tare da acid glutamic yana haɓaka ɗaukar sauri daga wurin allura.
Kasancewa da Bioavailability
Lokaci na maida hankali akan Pharmacokinetic a cikin masu sa kai masu lafiya da marasa lafiya da ke da nau'in 1 da na ciwon sukari guda 2 ya nuna cewa shan insulin glulisin idan aka kwatanta shi da insulin ɗan adam mai narkewa shine kusan sau 2 cikin sauri, wanda yakai kusan sau 2 mafi yawan maida hankali.
A cikin binciken da aka gudanar a cikin marasa lafiya da nau'in ciwon sukari na 1 na mellitus, bayan sc gudanar da insulin glulisin a cikin kashi 0.15 IU / kg, an sami C max bayan 55 min kuma yana 82 ± 1.3 microME / ml idan aka kwatanta da C max na narkewar ɗan adam mai narkewa, wanda aka samu bayan 82 min, ya kasance 46 ± 1.3 microMEU / ml. Lokacin zama a cikin tsari na yaduwar insulin glulisin ya yi guntu (98 min) sama da na insulin ɗan adam mai narkewa (161 min). A cikin bincike a cikin marasa lafiya da nau'in ciwon sukari na 2 na sukari bayan sc gwamnatin insulin glulisin a cikin kashi 0.2 IU / kg, Cmax shine 91 microME / ml (78 zuwa 104 microME / ml).
Tare da subcutaneous management na insulin glulisin a cikin bangon ciki na ciki, cinya ko kafada (yanki na deltoid tsoka), sha yana da sauri lokacin da aka gabatar dashi a bangon ciki na ciki idan aka kwatanta da gudanarwar miyagun ƙwayoyi a cinya. Yawan sha daga yankin da aka kera ya kasance tsaka-tsaki. Cikakken bioavailability na insulin glulisin (70%) a wuraren allura iri ɗaya ya kasance yana da ɗan bambanci tsakanin marassa lafiya daban-daban (adadinsu na rarrabuwa - 11%).
Rarraba da Sacewa
Rarraba da kewayon insulin glulisin da mai narkewa na mutum bayan aikin iv sun kasance iri ɗaya, V d ita ce 13 L kuma 22 L, T 1/2 shine 13 da 18 min, bi da bi.
Bayan sc gudanar da insulin, glulisin an keɓe shi sama da insulin ɗan adam mai narkewa: a wannan yanayin, T 1/2 shine minti 42 idan aka kwatanta da T 1/2 na insulin ɗan adam na minti 86 A cikin binciken giciye-bincike na binciken glulisin insulin a duka mutane masu lafiya da waɗanda ke da nau'in 1 da 2 na ciwon sukari, T 1/2 ya kama daga minti 37 zuwa 75.
Pharmacokinetics a cikin lokuta na musamman na asibiti
A cikin binciken asibiti da aka gudanar a cikin mutane ba tare da ciwon sukari ba tare da yanayin yanayin kodan (CC fiye da 80 ml / min, 30-50 ml / min, ƙasa da 30 ml / min), an kiyaye farkon tasirin insulin glulisin gabaɗaya. Koyaya, ana buƙatar rage insulin a cikin gazawar renal.
A cikin marasa lafiya waɗanda ke fama da aikin hanta mai rauni, ba a yi nazarin sigogi na pharmacokinetic ba.
Akwai iyakataccen shaida a kan pharmacokinetics na insulin glulisin a cikin tsofaffi marasa lafiya da ciwon sukari mellitus.
An yi nazarin abubuwan da ke cikin pharmacokinetic da pharmacodynamic na insulin glulisin a cikin yara (shekaru 7-11) da matasa (12-16 years) tare da nau'in ciwon sukari na 1 a cikin duka shekarun biyu, insulin glulisin yana saurin hanzari, yayin da lokacin nasara da darajar C max suke daidai da na manya. Kamar yadda yake a cikin manya, lokacinda aka gudanar dashi kai tsaye gabanin gwajin abinci, glulisin insulin yana samarda mafi kyawun sarrafa glucose na jini bayan abinci fiye da insulin na mutum. Increasearin yawan haɗarin glucose na jini bayan cin abinci (AUC 0-6 h) ya kasance 641 mg? H? Dl -1 don insulin glulisin da 801 mg? H? Dl -1 don insulin ɗan adam mai narkewa.
Ciwon sukari mellitus yana buƙatar magani insulin (a cikin manya).
Ya kamata a gudanar da Apidra a takaice (0-15 mintuna) kafin ko jim kaɗan bayan cin abinci.
Ya kamata a yi amfani da Apidra a cikin hanyoyin kulawa da suka haɗa da ko dai insulin na matsakaici ne ko insulin yin aiki na dogon lokaci ko kwatancin insulin. Za'a iya amfani da miyagun ƙwayoyi a hade tare da wakilai na hypoglycemic na bakin.
Zaɓaɓɓen tsari na magungunan Apidra an zaɓi daban daban.
Ana gudanar da Apidra ko dai ta hanyar allura ta sc ko kuma ta ci gaba da jikowa zuwa cikin kitse mai cin nasara ta amfani da tsarin aikin famfo.
Ya kamata a sanya allurar cikin ciki a cikin ciki, kafada ko cinya, kuma ana gudanar da maganin ne ta hanyar jiko cikin kitse a cikin ciki. Dole ne a canza wuraren allurar da jiko a cikin sassan da ke sama (ciki, cinya ko kafada) tare da kowane sabon tsarin maganin.Rage yawan sha kuma, saboda haka, farawa da tsawon lokacin aiwatarwa zai iya shafar shafin yanar gizon gudanarwa, aikin jiki, da sauran yanayin canzawa. Gudanarwa na SC zuwa bango na ciki yana samar da ɗan ɗan sauri fiye da gudanarwa ga sauran sassan da aka ambata a sama na jikin mutum.
Dole ne a kiyaye yin rigakafin don hana magungunan shiga hanyoyin jini kai tsaye. Bayan gudanar da maganin, ba shi yiwuwa a tausa yankin gudanarwa. Yakamata a horar da marassa lafiya yadda ya kamata.
Hada insulin
Bai kamata a cakuda Apidra tare da wasu magunguna ba face isofan-insulin ɗan adam.
Umpwararren na'urar don yin gaba da jiko
Lokacin amfani da Apidra tare da tsarin aikin famfo don jiko insulin, ba za'a iya haɗuwa dashi da wasu kwayoyi ba.
Dokoki don amfani da miyagun ƙwayoyi
Domin Apidra shine mafita, sake tayarda hankali kafin amfani ba'a buƙata.
Hada insulin
Lokacin da aka haɗu da ɗan adam isofan-insulin, an fara shigar da Apidra cikin sirinji. Ya kamata a aiwatar da allurar kai tsaye bayan hadawa, kamar yadda babu bayanai game da amfani da gaurayawar da aka shirya sosai kafin allurar.
Ya kamata a yi amfani da katako tare da alkalami na insulin, kamar OptiPen Pro1, kuma daidai da shawarwarin da ke cikin umarnin mai ƙirar na'urar.
Umarnin mai ƙira don yin amfani da alkalami na OptiPen Pro1 game da ɗaukar kicin, saka allura, da kuma sarrafa allurar insulin daidai. Kafin amfani, yakamata a bincika kuma a yi amfani da shi kawai idan maganin a bayyane yake, mara launi, kuma baya ɗauke da kwayoyin halitta. Kafin sanya katun a cikin takaddar sirinji mai warwarewa, ya kamata katarar ta kasance cikin zazzabi a daki na awa 1-2. Kafin yin allura, cire kumburin iska daga kicin ɗin (duba umarnin don amfani da alkairin sirinji). Ba za a iya cike kwandishan fanko ba. Idan alkairin OptiPen Pro1 ya lalace, baza'a iya amfani dashi ba.
Idan alkalami mai rauni yana da lahani, za a iya zazzage mafita daga kicin a cikin sirinji filastik wanda ya dace da insulin a cikin taro na 100 IU / ml kuma an gudanar da shi ga mai haƙuri.
Tsarin Kayan Tsarin Kaya
Tsarin katako na OptiClick shine katako mai gilashi wanda ke dauke da 3 ml na glulisin insulin, wanda aka sanya shi cikin kwandon filastik mai ma'ana tare da kayan piston mai haɗe.
Ya kamata a yi amfani da tsarin kabad ɗin OptiClick tare da alkalami na OptiClick sabanin shawarwarin da masana'antun na'urar suka bayar.
Umarnin mai ƙira don yin amfani da alkalami na OptiClick (dangane da loda katun katako, saka allura, da allurar insulin) dole ne a bi su daidai.
Idan alkairin OptiClick ya lalace ko baya aiki yadda yakamata (sakamakon lahani na inji), ya kamata a maye gurbinsa da mai aiki.
Kafin shigar da tsarin katun, alkalami na OptiClick dole ne ya kasance a zazzabi a daki na awa 1-2. Duba tsarin kicin kafin shigarwa. Yakamata a yi amfani da shi idan mafita a bayyane, mara launi, ba dauke da abubuwan daskararren da ake gani. Kafin yin allura, cire kumburin iska daga tsarin katun (duba umarnin amfani da alkairin sirinji). Ba za a iya cike kwandishan fanko ba.
Idan alkairin sirinji baya aiki yadda yakamata, za'a iya jawo mafita daga tsarin katun cikin sirinji mai filastik wanda ya dace da insulin a cikin taro na 100 IU / ml kuma an gudanar dashi ga mai haƙuri.
Don hana kamuwa da cuta, ya kamata a yi amfani da alkalami mai suttwa mai haƙuri don haƙuri ɗaya kawai.
Hypoglycemia - sakamako wanda ba a ke so shi ne na maganin insulin, wanda zai iya faruwa idan aka yi amfani da allurar insulin da yawa, ya wuce bukatar sa.
Abubuwan ƙarancin halayen da aka lura a cikin gwaji na asibiti da ke hade da gudanar da miyagun ƙwayoyi an jera su a ƙasa gwargwadon tsarin tsarin kuma don rage yawan abin da ya faru. A bayanin yadda aka saba faruwa, ana amfani da waɗannan ka'idodi masu zuwa: sau da yawa -> 10%, sau da yawa -> 1% da 0.1% da 0.01% da TATTAUNAWA
Hypersensitivity ga insulin glulisin ko ga wani ɓangaren magungunan.
Tare da taka tsantsan yakamata ayi amfani da shi yayin daukar ciki.
FASAHA DA LITTAFINSA
Lokacin da ake rubuta magani a lokacin daukar ciki, ya kamata a kula. Ana buƙatar kulawa da hankali akan matakan glucose na jini. Babu bayanan asibiti game da amfani da insulin glulisin yayin daukar ciki.
Marasa lafiya da ciwon sukari mellitus (gami da kwayar mahaifa) suna buƙatar kulawa da ingantaccen iko na rayuwa a cikin ciki. A cikin farkon watanni na ciki, bukatar insulin na iya raguwa, kuma a cikin na biyu da na uku, a matsayin mai mulkin, yana iya ƙaruwa. Nan da nan bayan haihuwa, bukatar insulin ya ragu da sauri.
A karatun gwaji Babu bambance-bambance a haihuwa tsakanin tasirin insulin glulisin da insulin mutum akan ciki, cigaban tayi da tayin, haihuwa da ci gaban haihuwa.
Ba'a sani ba ko yalwataccen insulin glulisin a cikin madarar ɗan adam, amma ba a ɓoye insulin a cikin madarar ɗan adam ba kuma ƙwayar cuta ta sha.
Yayin shayarwa (shayarwa), ana iya buƙatar daidaita sashin insulin da abinci.
Canja wurin mara lafiya zuwa wani sabon nau'in insulin ko insulin daga wani mai samarwa yakamata a gudanar dashi karkashin kulawar likita, kamar Ana iya buƙatar gyara duk jiyya mai gudana. Yin amfani da isasshen allurar insulin ko dakatar da magani, musamman a cikin marasa lafiya da ke dauke da ciwon sukari na 1, na iya haifar da cututtukan hyperglycemia da ketoacidosis - yanayin da ke da haɗari ga rayuwa.
Lokaci na yiwuwar haɓakawar hypoglycemia ya dogara da ƙarancin farawar tasirin insulin da aka yi amfani dashi kuma, a wannan batun, na iya canzawa tare da canji a tsarin kulawa. Halin da zai iya canzawa ko pronounasa bayyana ainihin abubuwan da ke faruwa na rashin lafiyar hypoglycemia sun hada da ci gaba da ciwon sukari mellitus, ci gaba da maganin insulin, kasancewar ciwon sukari na ciwon sukari, amfani da wasu magunguna (kamar masu hana ruwa), ko kuma canja wurin mara lafiya daga insulin na asalin dabba zuwa insulin mutum.
Hakanan ana iya buƙatar gyaran insulin allurai yayin canza tsarin motsa jiki ko abinci. Yin motsa jiki wanda aka yi shi nan da nan bayan cin abinci na iya ƙara haɗarin hauhawar jini. Idan aka kwatanta da insulin na ɗan adam mai narkewa, hypoglycemia na iya haɓaka a farkon bayan allurar insulin analogues mai sauri.
Abubuwan da ba a san yawan su ba ko kuma maganganun rashin motsa jiki na iya haifar da asarar sani, ko na ciki, ko mutuwa.
Bukatar insulin na iya canzawa tare da cututtuka masu rikitarwa ko ɗumbin damuwa.
Kwayar cutar babu takamaiman bayanai akan yawan zubar insulin glulisin, zazzagewar cututtukan jini na iya haifar da ci gaba.
Jiyya: sassan abubuwa masu saurin motsa jiki za a iya tsayar dasu tare da glucose ko abinci mai ɗauke da sukari.Sabili da haka, an ba da shawarar cewa marasa lafiya da ciwon sukari koyaushe suna ɗaukar sukari, alewa, kukis ko ruwan 'ya'yan itace mai zaki. Abubuwan da ke tattare da rashin ƙarfi a cikin jini, a lokacin da mara haƙuri ke rasa hankali, ana iya dakatar da shi ta hanyar i / m ko s / c ta hanyar gudanar da 0.5-1 mg na glucagon ko iv ta dextrose (glucose) Idan mai haƙuri bai amsa glucagon ba na minti 10-15, Hakanan ya zama dole don gabatar da tsarin kwalliyar ciki. Bayan ya dawo cikin nutsuwa, ana ba da shawarar cewa a bai wa mara lafiya carbohydrates a ciki don hana sake komawa cikin cututtukan haila. Bayan gudanar da glucagon, ya kamata a lura da mai haƙuri a asibiti don kafa dalilin wannan mummunan cutar hypoglycemia kuma ya hana ci gaba da waɗannan alamomin irin wannan.
Ba a gudanar da bincike kan hulɗa da magungunan ƙwayoyin magunguna ba. Dangane da ilimin da ke akwai game da wasu magunguna masu kama, irin bayyanar da hulɗa a likitancin ba zai yiwu ba. Wasu abubuwa na iya shafar metabolism na metabolism, wanda na iya buƙatar daidaita sirin jiki na insulin glulisin kuma musamman saka idanu akan far da yanayin haƙuri.
Lokacin amfani tare, wakilai na hypoglycemic na baka, ACE inhibitors, biyayyapyramids, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates da magungunan antioxideam na sulfonamide na iya haɓaka tasirin hypoglycemic na insulin kuma ƙara haɓakar cutar zuwa hypoglycemia.
Tare da haɗakar amfani da GCS, danazole, diazoxide, diuretics, isoniazid, abubuwan asali na phenothiazine, somatropin, sympathomimetics (misali, epinephrine / adrenaline /, salbutamol, terbutaline), hormones na thyroid, estrogens, progestins (misali, oral contraiss (eiss, oral contraiss) kwayoyi (misali, olanzapine da clozapine) na iya rage yawan tasirin insulin.
Beta-blockers, clonidine, salts na lithium ko ethanol na iya ɗaukar ƙarfi ko raunana tasirin rashin lafiyar insulin. Pentamidine na iya haifar da hypoglycemia wanda hyperglycemia ya biyo baya.
Lokacin amfani da kwayoyi tare da ayyukan tausayawa (beta-blockers, clonidine, guanethidine da reserpine), alamu na reflex adrenergic kunnawa tare da hypoglycemia na iya zama ƙasa da sanarwa ko ba ya nan.
Saboda rashin karatun karfin jituwa, insulin glulisin bai kamata a hade shi da wasu magunguna ba sai dai isofan-insulin na mutum.
Lokacin gudanar da shi tare da famfo na jiko, Apidra bai kamata a hade shi da wasu kwayoyi ba.
HUKUNCIN FARKON FARKO
Magungunan magani ne.
SHAWARA DA KUDURAI
Ya kamata a adana katako na katako na OptiKlik da ƙananan katun daga isar yara, a kiyaye shi daga haske a zazzabi 2 ° zuwa 8,
Bayan fara amfani da katako da tsarin katun katako na OptiClick yakamata a adana su har zuwa ga yara, kiyaye shi daga haske a zazzabi da bai wuce 25 ° C.
Don kariya daga fallasawa zuwa haske, adana manyan hanyoyin katako na OptiKlik da kuma tsarin katun a cikin akwatinan su.
Rayuwar shelf shine shekaru 2. Rayuwar shiryayye na miyagun ƙwayoyi a cikin kabad, OptiClick tsarin jigilar bayan amfani na farko shine 4 makonni. Ana bada shawara don alamar ranar farkon cire magunguna akan alamar.
Typeaya daga cikin nau'in insulin na kasuwanci da ke cikin Pharmacy shine insulin apidra. Wannan magani ne mai inganci, wanda, bisa ga umarnin likita, za'a iya amfani dashi a nau'in I masu ciwon sukari a cikin yanayi idan ba a samar da insulin ɗin nasu ba kuma dole ne a allurar dashi. Ana ba da magani ta hanyar sayan magani kuma yana buƙatar ƙididdige hankali game da sashi. Ana nuna shi ta babban ƙarfin aiki lokacin da aka yi amfani da shi daidai.
Alamu, alamu
Ana amfani da magani don nau'in 1 na ciwon sukari azaman madadin insulin na halitta, wanda ba a haifar da wannan cutar (ko kuma ba'a samar da shi da ƙarancin yawa). Hakanan za'a iya wajabta shi don cutar ta nau'in na biyu a cikin yanayin yayin da juriya (rigakafi) ga magungunan glycemic na baka.
Yana da insulin apidra da contraindications. Kamar kowane irin wannan magani, ba za a iya ɗauka tare da hali ko gaban kai tsaye na hypoglycemia ba. Rashin yarda da babban aikin kwayoyi ko abubuwanda ke tattare da shi kuma yana haifar da gaskiyar cewa dole ne a soke shi.
Aikace-aikacen
Ka'idojin ka'idodin sarrafa magunguna sune kamar haka:
- An gabatar da shi gabanin (ba a wuce mintina 15 ba) ko kuma nan da nan bayan abinci,
- Ya kamata a yi amfani dashi a hade tare da insulins masu aiki na dogon lokaci ko nau'ikan jiyya na baka,
- An saita sashi gwargwado ne a alƙawari tare da halartar malamin lafiyar,
- Ana gudanar da aikin karkashin kasa,
- Wuraren allurar da aka fi so: cinya, cinikin ciki, ƙyallen ciki, buttock,
- Wajibi ne a sauya wuraren allurar,
- Lokacin da aka gabatar da shi ta bango na ciki, ana shan maganin kuma yana farawa da sauri,
- Ba za ku iya tausa wurin yin allura ba bayan an sha maganin,
- Dole ne a kula sosai don kar a lalata bututun jini,
- Game da keta hakkin al'ada na ƙodan, yana da buƙatar ragewa da sake sarrafawa sashi na maganin,
- Game da aiki na hanta mai rauni, ya kamata a yi amfani da miyagun ƙwayoyi tare da taka tsantsan - ba a gudanar da irin waɗannan nazarin ba, amma akwai dalilin da za a yi imani cewa ya kamata a rage yawan sashi a cikin wannan yanayin, tunda buƙatar insulin ta ragu saboda raguwar glucogenesis.
Kafin fara amfani da shi, dole ne ka ziyarci likitanka don yin ƙididdigar yawan ƙwayoyi
Epidera na miyagun ƙwayoyi yana da analogues tsakanin insulins. Wadannan kudade suna da babban aiki guda, amma suna dauke da sunan kasuwanci daban. Suna da sakamako iri ɗaya a jiki. Waɗannan kayan aikin sune:
Lokacin canzawa daga wannan magani zuwa wani, har ma da analog, kuna buƙatar tuntuɓi likita.
Game da Insulin Apidra
Hanyar da za a bi don magance cututtukan cututtukan ƙwayar cuta suna da tasiri sosai kuma, a lokaci guda, nesa da dukkan su ana iya jure wa jikin mutum. Abubuwan da suka fi dacewa da inganci a wannan batun su ne insulins-gajere. Suna taimakawa da yawa daga masu ciwon sukari kuma suna iya yiwuwa a mayar da jikin, da kuma narkewar abinci, da sauri. Menene zai yiwu a faɗi game da insulin na Apidra?
A abun da ke ciki da nau'i na sakin
Don haka, Apidra insulin ne mai gajeren zango. Daga matsayin duba yanayin hada-hadar kudi - wannan shine mafita. An yi niyya ne don gudanar da aikin ƙarƙashin ƙasa kuma yana da cikakke bayyananne har da mara launi (a wasu lokuta, ɗan ƙaramin inuwa har yanzu yana nan).
Babban ɓangarensa, wanda yake a cikin rashi kaɗan a cikin, ya kamata a yi la'akari da insulin da ake kira glyzulin, wanda yanayinsa da saurin aiki da sakamako mai dorewa. Wadanda suka ware sune:
- cresol
- daikin,
- sinadarin sodium
- polysorbate da yawa wasu, ana samun su a.
Dukkaninsu sun haɗu tare suna samar da tsari ba tare da wataƙila wani magani na musamman da za'a iya samu tare da kowane nau'in ciwon sukari ba: na farko da na biyu. Ana samar da insulin na Apidra a cikin nau'i na katako na musamman waɗanda aka yi da gilashin launi.
Game da tasirin magunguna
Yaya Apidra ke shafan glucose?
Glulin insulin shine farfadowar hormone mutum.Kamar yadda kuka sani, yana iya zama da kwatankwacin ƙarfi don narkewar insulin na ɗan adam, amma halayyar ce ta fara "aiki" da sauri kuma yana da ɗan gajeren lokaci na fallasa. wannan ya fi amfani.
Mafi mahimmancin gaske da tasiri na yau da kullun ba wai kawai ga insulin ba, har ma da analogues dinsa, ya kamata a yi la'akari da kullun ka'idoji dangane da canzawar glucose. Hoton da aka gabatar yana rage yawan sukari a cikin jini, wanda ke karfafa yin amfani da glucose tare da taimakon tsokoki na waje, kamar yadda tare da. Wannan gaskiyane musamman ga tsokawar kasusuwa da tsoka nama. Har ila yau, insulin na Apidra yana hana samuwar glucose a cikin hanta. Bugu da kari, yana katse dukkanin hanyoyin da suka danganci lipolysis a cikin adipocytes, kariya da kuma haɓaka hulɗa da furotin.
Dangane da sakamakon binciken da yawa, an tabbatar da cewa glulisin, shine babban bangaren kuma ana gabatar dashi minti biyu kafin cin abinci, zai iya samar da iko guda ɗaya na adadin glucose bayan cin abinci kamar irin na ɗan adam wanda ya dace da rushewa. Koyaya, yakamata a gudanar dashi minti 30 kafin cin abinci.
Game da sashi
Mafi mahimmancin batun aiwatar da kowane irin magani, gami da maganin insulin, yakamata a yi la'akari da bayyanar sashi. Ana ba da shawarar Apidra da za a gabatar da shi jim kaɗan (don ƙarancin sifili da matsakaicin mintina 15) kafin ko nan da nan bayan cin abinci.
Za'a iya amfani da miyagun ƙwayoyi a haɗe tare da takamaiman nau'ikan nau'ikan cututtukan jini.
Yadda za a zabi kashi na Apidra?
Ya kamata a zaɓi allurar insulin dosing algorithm daban-daban kowane lokaci. A cikin taron cewa ana gano gazawar renal, raguwa a cikin buƙatar wannan hormone yana yiwuwa.
A cikin masu ciwon sukari tare da nakasa aiki na wannan sashin jiki kamar hanta, buƙatar samar da insulin ya fi ƙarfin ragewa. Wannan ya faru ne saboda rage karfin glucose neogenesis da raguwar metabolism dangane da insulin. Duk wannan yana bayyana ma'anar bayyananne kuma, ba ƙaramin mahimmanci ba, biye da maganin da aka nuna, yana da matukar muhimmanci a lura da ciwon sukari.
Game da allura
Dole ne a gudanar da maganin ta hanyar allurar subcutaneous, kazalika da ci gaba da jiko. An bada shawarar yin wannan na musamman a cikin kasusuwa da ƙoshin kitse ta amfani da tsarin aikin famfo na musamman.
Dole ne a aiwatar da injections na Subcutaneous in:
Ya kamata a gabatar da insulin na Apidra ta amfani da jinkirin jiko a cikin kashi mai ƙwaya ko mara mai kyau a cikin ciki. Bangarorin ba wai kawai allura ba ne, har ma da abubuwan da aka samar a bangarorin da aka gabatar, kwararru sun bada shawarar musayar junan su don kowane sabon tsarin na bangaren. Irin waɗannan abubuwan kamar yankin dasawa, aikin jiki, da sauran yanayin "iyo" na iya samun tasiri akan girman hanzarin ɗaukar ciki kuma, sakamakon hakan, a kan ƙaddamar da girman tasirin.
Yaya ake bayar da allura?
Shiga ciki daga ciki zuwa bangon yankin na ciki ya zama garanti na mafi yawan hanzarin jan ciki fiye da shigar cikin wasu sassan jikin mutum. Tabbatar ka bi ka'idodin ka'idodi don kauda abubuwan ci gaba na miyagun ƙwayoyi a cikin tasoshin jini na nau'in jini.
Bayan gabatarwar insulin "Apidra" an hana shi tausa wurin allurar. Hakanan ya kamata a koyar da masu ciwon sukari kan madaidaicin dabarar allurar. Wannan zai zama mabuɗin hanyar ingantaccen magani 100%.
Game da yanayin ajiya da sharuɗɗa
Don iyakar sakamako a cikin aiwatar da amfani da kowane ɓangaren magani, wanda ya isa ya tuna da yanayin da rayuwar shiryayye.Don haka, katako da tsarin nau'ikan wannan nau'in dole ne a adana su a wuri mai sauƙi ga yara, wanda ya kamata kuma ya kasance yana nuna mahimmancin kariya daga haske.
A wannan yanayin, dole ne a lura da tsarin zafin jiki, wanda ya kamata ya kasance daga digiri biyu zuwa takwas.
Dole ne a sanya kayan sakin jiki mai sanyi.
Bayan da aka fara amfani da tsarin katako da kayan katun, sun kuma buƙaci a ajiye su a wani wuri wanda ba zai yiwu ga yara waɗanda ke da amintaccen kariya ba kawai daga shigar azkar ba, amma har daga hasken rana. A lokaci guda, alamu zazzabi kada su wuce digiri 25 na zafi, in ba haka ba wannan zai iya fada akan ingancin insulin na Apidra.
Don ƙarin tabbatacciyar kariya daga tasirin haske, ya zama dole don adana ba katunan katako ba kawai, amma masana sun ba da shawarar irin waɗannan tsarin a cikin fakitin nasu, wanda aka yi da kwali na musamman. Rayuwar shiryayye daga abubuwan da aka bayyana shine shekara biyu.
Duk game da ranar karewa
Rayuwar shiryayye na ƙwayar cuta wanda ke cikin kicin ko wannan tsarin bayan amfani na farko shine makonni huɗu. Yana da kyau a tuna cewa lambar da aka ɗauki farkon insulin ɗin ta yi alama akan kunshin. Wannan zai zama ƙarin garantin don nasarar ci gaban kowane nau'in ciwon sukari.
Game da sakamako masu illa
Ya kamata a lura da tasirin gefen da ke rarrabe insulin insulin. Da farko dai, muna magana ne game da irin wannan abu a matsayin hypoglycemia. An kirkiro shi ne saboda yawan amfani da insulin mai yawa, watau, wadanda suka zama sun fi ainihin bukatar hakan.
A wani ɓangaren irin wannan ƙwayar ƙwayar ƙwayar cuta kamar yadda metabolism yake, hypoglycemia shima yana daɗaɗɗa. Duk alamun bayyanar sa an san shi kwatsam: akwai gurnani mai sanyi, rawar jiki da ƙari. Hadarin a cikin wannan yanayin shine hypoglycemia zai karu, kuma wannan na iya haifar da mutuwar mutum.
Hakanan halayen gida zasu iya yiwuwa, waxanda sune:
- hyperemia,
- puff,
- gagarumar itching (a wurin allura).
Wataƙila, ban da wannan, haɓakar halayen rashin lafiyan yanayi, a wasu yanayi muna magana ne game da cutar urticaria ko rashin lafiyar mahaifa. Koyaya, wasu lokuta wannan ba yayi kama da matsalolin fata ba, amma kawai cire kaya ko wasu alamu na zahiri. A kowane hali, babu wata illa da za a iya amfani da ita ta hanyar amfani da shawarwarin da kuma tunawa da ingancin amfani da insulin kamar Apidra.
Game da contraindications
Ya kamata a ba da kulawa ta musamman don kowane ƙwayoyi don kulawa ta musamman. Wannan zai zama mabuɗin gaskiyar cewa insulin zai yi aiki a 100%, kasancewa ingantacciyar hanyar ingantacciyar hanyar dawo da kuma kare lafiyar jiki. Don haka, contraindications yana hana yin amfani da "Apidra" ya kamata ya haɗa da hypoglycemia barga da haɓaka digiri na hankali zuwa insulin, gluzilin, da duk wani ɓangaren magunguna.
Shin mata masu ciki zasu iya amfani da Apidra?
Tare da kulawa ta musamman, yin amfani da wannan kayan aikin ya zama dole ga waɗannan matan waɗanda suke kowane mataki na ciki ko shayarwa. Tunda nau'in insulin da aka gabatar shine magani ne mai ƙarfi sosai, yana iya haifar da wata illa ba ga mace kaɗai ba, har ma ga tayin. Koyaya, wannan tabbas yana da nisa daga duk lamurran da suka danganci ciwon sukari. A cikin wannan haɗin, an ba da shawarar cewa ka fara tuntuɓar ƙwararren likita wanda zai nuna halatta amfani da insulin na Apidra, sannan kuma ya tsara gwargwadon abin da ake so.
Game da alamomi na musamman
A yayin aiwatar da amfani da kowane irin ƙwayoyi, ya zama dole a yi la’akari da ƙima mai yawa na halayen daban.Misali, canjin mai cutar sikari zuwa sabon nau'in insulin ko wani abu daga wata damuwa yakamata a gudanar dashi karkashin kulawa ta musamman. Wannan ya faru ne saboda gaskiyar cewa za'a iya buƙatar gaggawa don daidaitawa da ilimin gabaɗaya.
Amfani da rashin isasshen magungunan sashi ko dakatar da magani, musamman a cikin mutanen da ke fama da nau'in ciwon sukari na 1, zai iya haifar da haifar da hyperglycemia ba kawai ba, har ma takamaiman ketoacidosis. Waɗannan halaye ne waɗanda a haɗarin gaske ga rayuwar ɗan adam.
Daidaitawar alluran insulin na iya zama dole idan akwai wani sauyi a cikin tsarin aikin cikin shirin motar ko lokacin cin abinci.
Labarin yana taimaka sosai. Ina tsammanin mutane da yawa waɗanda ke fama da wannan cutar za su taimaka. Na gode da cikakken bayanin yadda ake adana wannan magani. Likita da kansa ya kuma wajabta shi. An rubuta labarin da yawa mai kyau, Ina fata kuma zai taimake ni!
Apidra insulin ɗan adam ne mai ɗan gajeren lokaci.
• Menene abin da ake ciki na insid ɗin insidra da sakin saki?
An fito da miyagun ƙwayoyi ta hanyar bayyananne, mai warwarewar launi, wanda aka yi nufin gudanarwa a ƙarƙashin fata. Abubuwan da ke aiki da wannan wakili shine insulin glulisin.
Mahalarta: ruwa don yin allura, m-cresol, sodium hydroxide, trometamol, polysorbate 20, sodium chloride, acid mai karfi hydrochloric acid.
Ana kawo magungunan a cikin gilashin gilashin, an sanya su cikin fakiti mai bakin ciki. Dole ne a adana tsarin kabad na Optiklik a cikin ɗakin firiji, ta hanyar isa ga yara, an contraindicated don daskare miyagun ƙwayoyi.
Rayuwar shiryayye na Apidra shekaru biyu ne. Sayar da magani bayan amfani na farko kada ya wuce makonni huɗu. Ana bada shawara don sanya alama a kan lakabin. Bar da takardar sayan magani.
• Menene tasirin magungunan ƙwayoyin cutar ta Apidra?
Ana ɗaukar insulin glulisin wani misalincin insulin ne na ɗan adam, dangane da iko wannan magani yana daidai da insulin ɗan adam mai narkewa, amma farkon aiwatarwa yana da sauri. Wannan miyagun ƙwayoyi yana daidaita metabolism a cikin jiki, yana rage yawan hankali, yana ƙarfafa haɓakawarsa ta hanyar adipose nama da tsokoki na kasusuwa.
Insulin yana rage lipolysis kuma yana inganta haɓakar furotin. Tare da gudanarwa na subcutaneous, haɓakar tasirin hypoglycemic yana faruwa a cikin minti goma.
• Menene alamun insulin na Apidra don amfani?
An nuna magungunan don amfani da ciwon sukari, kuma ana iya tsara shi daga shekaru shida.
• Mene ne abubuwan hana insulin cikin su?
Daga cikin maganin contraindications Apidra, umarnin don amfani da jerin abubuwan yanayi kamar yanayin hypoglycemia, hypersensitivity ga bangaren aiki, kuma ana amfani da maganin tare da taka tsantsan yayin daukar ciki.
• Menene apidra insulin amfani da sashi?
Dole ne a zabi tsarin kula da maganin ta hanyar likita endocrinologist dangane da tsananin cutar mai haƙuri. Tare da gazawar koda, har ma da cutar koda, ana rage raguwar buƙatar insulin.
Gabatar da miyagun ƙwayoyi ana yin su ne da ƙyalli a cikin cinya, cinya ko kafada, ko zaku iya gudanar da jinkirin ci gaba da kitse a cikin ƙananan ciki. An bada shawarar wurin yin allurar don maye gurbin.
Yawan shaye maganin yana shafar aikin jiki, da sauran yanayi. Kada a cire shigo da miyagun ƙwayoyi cikin jijiyoyin jini, kuma bai kamata a yi masar da kai tsaye ba. Wajibi ne a koyar da mara lafiyar dabarar allurar.
Ana amfani da katako ta hanyar da ka'idodi da aka bayyana a cikin umarnin magunguna na Apidra.Baza a cika ridan harsashinan fanko ba; Idan alkalami ya lalace, ba za'a yi amfani dashi ba.
Tare da yawan yawan zubar da jini na Apidra, yanayin haɓaka na jini ya hauhawa. A wannan yanayin, wajibi ne don gudanar da gyaran yanayin mai haƙuri, alal misali, zaku iya amfani da samfuran da suka haɗa da sukari. Dangane da haka, mutumin da ke fama da ciwon sukari ya kamata ko da yaushe ya sami ɗan sukari ko etsan leƙa, ko kuma ruwan 'ya'yan itace mai ɗorewa.
A cikin hypoglycemia mai tsanani, mutum ya rasa hankali, to dole ne a gudanar da glucagon ko dextrose intramuscularly. Idan a cikin minti 10 babu wani ingantaccen kuzari, to ana sarrafa waɗannan magungunan cikin hanji. Bayan al'ada al'ada, ya wajaba barin mai haƙuri a asibiti na ɗan lokaci don dubawa.
• Menene abubuwanda ke haifar da illa?
Hypoglycemia an dauki babban sakamako ne na tasirin insulin, wannan yanayin yana haɓaka tare da gabatarwar manyan allurai na Apidra. Wannan halin, a matsayin mai mulkin, yana faruwa ba zato ba tsammani, mutum yana jin gumi mai sanyi, fatar jiki ta zama mara nauyi, gajiya, rawar jiki, rauni ya faru, yunwar, rikicewa, nutsuwa, tashin hankali na gani, tashin zuciya, tashin zuciya ya shiga.
Hypoglycemia na iya haifar da asarar hankali kuma yana haifar da shaƙa, kuma a wasu yanayi har zuwa mutuwa. Daga cikin halayen gida, jan zazzabi da kumburi za a iya lura dasu kai tsaye a wurin allurar, a lokuta mafi ƙaranci, lipodystrophy ya bayyana.
Allergic halayen za a bayyana a cikin nau'i na urticaria, dermatitis, za'a iya samun itching da kurji, kazalika da shaƙa. A cikin mawuyacin hali, rashin lafiyan yana ɗaukar halayen da ke tattare da yanayin tashin hankali wanda ke tasowa, wanda ke buƙatar magani nan da nan, tunda wannan yanayin yana da haɗari ga rayuwa.
Yin amfani da isasshen allurai na insulin na iya haifar da ketoacidosis da haɓakar haɓaka. Yi motsa jiki nan da nan bayan cin abinci yana kara haɗarin hawan jini.
• Menene Apidra insulin analogues?
Humalong da NovoRapid za a iya danganta su da kwayoyi na analogues, kafin amfani da su ya zama dole a nemi likita.
Ya kamata a yi amfani da Apidra ne kawai bayan alƙawaran ƙwararrun likitancin endocrinologist.