Protafan NM Penfill - umarnin * amfani don amfani

Dakatarwa don gudanarwar subcutaneous, 100 IU / ml

1 ml na dakatarwa ya ƙunshi

abu mai aiki - Injinin injin ɗan adam ɗan adam (insulin-isophan) 100 IU (3.5 mg),

magabata: sulfate protinine, zinc, glycerin, metacresol, phenol, sodium hydrogen phosphate dihydrate, 2 M sodium hydroxide, 2 M hydrochloric acid, ruwa don allura.

Wani farin dakatarwa, wanda, lokacin da yake tsaye, yakan bayyanar dashi cikin bayyananniyar, mara launi ko kusan madaukakiyar launi da farin fari. A sauƙaƙe za a sake tura shi cikin saurin girgiza kai.

Kayan magunguna

Pharmacokinetics

Tsawon lokacin aiwatar da shirye-shiryen insulin shine mafi yawanci saboda yawan sha, wanda ya dogara da dalilai da yawa (alal misali, kan yawan insulin, hanyar da wurin gudanarwa, kauri daga cikin yawan kitse mai cutarwa da nau'in ciwon sukari mellitus). Sabili da haka, sashin magungunan insulin na insulin ya shafi mahimmancin canzawa tsakanin mutum-da-ciki.

Matsakaicin ƙwayar insulin (Cmax) na insulin a cikin plasma an kai shi a cikin sa'o'i 2-18 bayan gudanarwa na ƙarƙashin ƙasa.

Babu wata ma'anar da aka ambata ta danganta ga furotin na plasma da aka ambata, banda abubuwan rigakafi ga insulin (idan akwai).

An cire insulin na mutum ta hanyar aikin insulin protease ko enzymes-insulin share abubuwa, da kuma, ta yiwu, ta hanyar abubuwan da ke lalata furotin isomerase. Ana zaton cewa a cikin kwayar halittar insulin na mutum akwai wurare da yawa na share-fage (hydrolysis), duk da haka, babu wani daga cikin metabolites da aka kirkira sakamakon ɗaukar aiki da ke aiki.

Rabin-rabi (T½) an ƙaddara shi da ƙimar sha daga ƙwaƙwalwar subcutaneous. Don haka, T½ shine mafi girman matakan sha, maimakon ainihin matakin cire insulin daga plasma (T½ na insulin daga cikin jini kawai 'yan mintuna). Bincike ya nuna cewa T½ kusan awa 5-10.

Pharmacodynamics

Protafan® NM wani aiki ne na matsakaiciyar ɗan adam wanda aka samar da shi ta hanyar kimiyyar halittar halittar DNA ta hanyar amfani da ƙwaƙwalwar Saccharomyces cerevisiae. Raguwar matakin glucose a cikin jini na faruwa ne sakamakon haɓaka jigilar kwayoyin halittar jikinta bayan ɗaukar nauyin insulin ga masu karɓar ƙwayar tsoka da kyallen takaddar adipose da kuma raguwa a lokaci guda na yawan samarwar glucose ta hanta.

Ayyukan miyagun ƙwayoyi yana farawa a cikin awa 1 after bayan gudanarwa, ana nuna mafi girman tasirin a cikin sa'o'i 4-12, yayin jimlar yawan aikin shine kusan awanni 24.

Sashi da gudanarwa

Magungunan an yi niyya ne don gudanar da tsarin mulki na ƙasa. Ba za a iya sarrafa insulin na cikin gida ba.

Ana iya amfani da Protafan® NM duka a cikin monotherapy kuma a hade tare da insulin mai sauri ko gajere.

An zaɓi kashi na miyagun ƙwayoyi daban-daban, la'akari da bukatun mai haƙuri. Yawanci, bukatun insulin tsakanin 0.3 da 1 IU / kg / rana. Bukatar yau da kullun don insulin na iya zama mafi girma a cikin marasa lafiya tare da juriya na insulin (alal misali, yayin balaga, har ma a cikin marasa lafiya tare da kiba), da ƙananan a cikin marasa lafiya tare da ragowar insulin na insulin.

Protafan® HM mafi yawanci ana gudanar dashi a ƙarƙashin yanki a cinya. Idan wannan ya dace, to ana iya yin allura a cikin bangon gaban ciki, a yankin gluteal ko kuma a cikin yanki na ƙwayar tsoka ta kafada. Tare da gabatarwar miyagun ƙwayoyi a cinya, akwai jan hankali a hankali fiye da lokacin da aka gabatar da shi zuwa wasu yankuna. Idan allurar tayi cikin shimfidar fata, to za a rage girman hadarin da ke tattare da gudanar da magunguna na cikin jiki.

Dole ne allurar ta kasance a cikin fata na akalla awanni 6, wanda ke tabbatar da cikakken kashi. Wajibi ne a canza wurin allura a koyaushe a cikin yankin ilmin jikin don hana haɓakar lipodystrophy.

Protafan® NM a cikin vials za a iya amfani da su kawai tare da sirinji insulin, wanda akan sa ma'aunin, yana ba ku damar auna kashi na insulin a cikin raka'a aiki.

Umarnin don amfani da Protafan® NM da za a ba wa mara lafiya.

Kada kayi amfani da Protafan® NM:

A cikin famfo na insulin.

Idan akwai rashin lafiyan (rashin lafiyan hankali) ga insulin ɗan adam ko kowane ɓangaren abin da ke haɗuwa da miyagun ƙwayoyi Protafan® NM.

Idan jinin haila ya fara (sukarin jini).

Idan ba a adana insulin da kyau ba, ko kuma a daskararre

Idan hula yana ɓacewa ko ya daskare. Kowane kwalban yana da filayen filastik mai kariya.

Idan insulin din bai zama fari fat da girgije ba bayan hadawa.

Kafin amfani da Protafan® NM:

Binciki alamar don tabbatar da cewa kuna amfani da insulin da ya dace.

Cire kwalban kariya.

Yadda ake amfani da miyagun ƙwayoyi Protafan® NM

Maganin Protafan® NM na miyagun ƙwayoyi an yi shi ne don gudanar da tsarin mulki na ƙasa. Karka taɓa sarrafa insulin cikin ciki ko intramuscularly. Koyaushe canza wuraren allura a cikin yanki na jiki don rage haɗarin ɗamarar hanji da ƙura a wurin allurar. Mafi kyawun wurare don injections sune: buttocks, gwiwoyi na baya ko kafada.

Yadda za'a gudanar da Protafan® NM idan Protafan® NM ne kawai ake sarrafawa ko kuma idan za'a hada Protafan® NM tare da insulin gajere

Tabbatar yin amfani da sirinji na insulin wanda akan sa ma'aunin don auna sashi a cikin raka'a aikin.

Zana iska a cikin sirinji a cikin adadin wanda yayi daidai da adadin insulin da ake so.

Nan da nan kafin ɗaukar kashi, mirgine murfin a cikin tafin hannunka har sai insulin ya kasance fari fari da gajimare. An sauƙaƙe tashin hankali idan ƙwayoyi suna da zazzabi a ɗakin.

Shigar da insulin a karkashin fata.

Rike allura a karkashin fata na akalla aƙalla 6 don tabbatar da cewa ana gudanar da aikin insulin sosai.

Cututtukan da ke haɗuwa, musamman masu kamuwa da cuta tare da zazzabi, yawanci suna ƙaruwa da buƙatar jikin mutum na insulin. Hakanan ana iya buƙatar daidaitawa koda idan mai haƙuri yana da cututtukan ƙwayoyin cuta na koda, hanta, nakasasshen aikin adrenal, pituitary ko glandar thyroid.

Buƙatar daidaitawa na iya faruwa yayin canzawar aiki na zahiri ko kuma irin abincin da mai haƙuri ya saba samu. Zai yiwu a buƙaci daidaitawa yayin canja wurin mai haƙuri daga nau'in insulin zuwa wani.

Side effects

Abubuwan da ba a yarda da su ba a cikin marasa lafiya da aka bi da Protafan® NM sun fi ƙarfin kashi-kashi kuma sun kasance ne saboda aikin insulin.

Followinga'idodi masu zuwa ne na yawan tasirin halayen da aka gano yayin gwaji na asibiti, waɗanda aka ɗauke su da alaƙa da amfani da miyagun ƙwayoyi Protafan® NM. An ƙaddara mitar kamar haka: akai-akai (≥1 / 1,000 zuwa

Yarjejeniyar:

Haihuwa da lactation
Babu ƙuntatawa game da amfani da insulin a lokacin daukar ciki, tunda insulin ba ya ƙetare shingen mahaifa ba. Haka kuma, idan ba ku kula da ciwon sukari ba yayin daukar ciki, to hakan yana haifar da: hadari ga tayin. Sabili da haka, dole ne a ci gaba da maganin cutar sankara yayin daukar ciki.
Dukkanin hypoglycemia da hyperglycemia, wanda zai iya haɓaka halayen cututtukan da aka zaɓa da kyau, suna kara haɗarin rikicewar tayin da mutuwar tayi. Ya kamata a sa ido ga mata masu juna biyu masu ciwon suga a duk lokacin da suke cikin ciki, suna buƙatar samun ingantaccen iko na matakan glucose na jini, shawarwari iri ɗaya sun shafi matan da ke shirin daukar ciki.
Bukatar insulin yawanci yana raguwa a farkon farkon ciki kuma sannu a hankali yana ƙaruwa a cikin na biyu da na uku.
Bayan haihuwa, bukatar insulin cikin sauri ta koma matakin da aka lura da shi kafin daukar ciki.
Hakanan babu wasu ƙuntatawa game da amfani da miyagun ƙwayoyi Protafan NM yayin shayarwa. Rashin lafiyar insulin ga mata masu shayarwa ba haɗari ga jariri. Koyaya, mahaifiyar na iya buƙatar sake saita tsarin magunguna na Protafan NM da / ko abinci.

Side sakamako:

Da wuya sosai - halayen anaphylactic.
Bayyanar cututtukan dake tattare da cutarwar jiki na iya hadawa da fatar fitsari, itching, sweating, rikicewar cikin jijiyoyi, angioedema, karancin numfashi, bugun jini, rage karfin jini, kasala / rauni.
Abubuwan da ke tattare da tsinkayewar jiki na iya zama barazanar rayuwa.

Rashin lafiyar tsarin juyayi
Da wuya sosai keɓaɓɓen neuropathy.
Idan an sami ci gaba a cikin ƙwayar glucose na jini da sauri, yanayin da ake kira "matsanancin raunin neuropathy" na iya haɓaka wanda yake yawan juyawa ne,

Vioarya ta sashin hangen nesa
Da wuya sosai - kurakurai masu narkewa.
Abubuwan da ke faruwa na nakasa yawanci ana lura da su a matakin farko na ilimin insulin.
A matsayinka na mai mulkin, waɗannan alamu suna juyawa.

Akai-akai - ciwon sukari na retinopathy.
Idan an samar da isasshen kulawar glycemic na dogon lokaci, yana rage haɗarin ci gaban cututtukan cututtukan fata. Koyaya, ƙarawar ƙwayar insulin tare da ingantacciyar haɓakawa a cikin sarrafa glycemic na iya haifar da karuwa na ɗan lokaci a cikin tsananin matsalar ciwon sukari.

Rashin lafiyar fata da ƙananan ƙwayar cuta
A lokaci-lokaci - lipodystrophy.
Lipodystrophy na iya haɓaka a wurin allura a cikin lamarin yayin da ba koyaushe suke canza wurin allurar ba a cikin ɓangaren ɓangaren jikin.

Rashin hankali daga jiki gabaɗaya, da kuma maganganu a wurin allurar
Akai-akai - halayen a wurin allurar.
A kan asalin ilimin insulin, halayen na iya faruwa a wurin allurar (redness na fata, kumburi, itching, soreness, hematoma samuwar a wurin allura). Koyaya, a mafi yawan lokuta, waɗannan halayen suna da natsuwa a cikin yanayi kuma sun ɓace yayin aiwatar da ci gaba da jiyya.

Sau da yawa - puffiness.
Yawancin lokaci ana lura da kumburi a matakin farko na farjin insulin. A matsayinka na mai mulkin, wannan alamar tana da sauki a yanayi.