Kwakwalwar ƙwallon ƙwayar cuta ta Antibiotic

Gaisuwa gareku!

Farfesan likitan mata ne suka rubuta mini wasikar, saboda haka maza sun fi maza duk abin da aka rubuta a ƙasa, zai fi kyau kada a karanta.

Shekaru biyu da suka gabata, na riga na rubuta sake dubawa kan taken "ina da mummunar shafawa"saboda haka aka sanya ni:

Don haka dole ne in sha wahala: magani bai ba da sakamako nan da nan ba. Kuma wannan lokacin kusan iri ɗaya ne.

Ban san abin da ke faruwa da jikina ba, amma matsalar mummunan suttura tana ɗaga farin farin sel -

sake ziyartar ni a wannan shekara. Kuma da alama babu wata c hurtta, akwai wani rashin jin daɗi, wanda kusan koyaushe yana faruwa a irin waɗannan halayen.

Gabaɗaya, Ni baƙi ne mai yawan zuwa likitan mata: gwajin duban dan tayi sau 2 a shekara da kuma shawarar wajibcin masanin ilimin likitan mata-endocrinologist. Gaskiyar ita ce cutar da na dadewa na kasance hyperplasia na endometrial.

Kwanan nan, Na gano cewa hyperplasia ne na endometrial na iya tsokani tsalle-tsalle cikin leukocytes a cikin smear - tunda kumburi mai mahimmanci na endometrium suna kasancewa koyaushe a cikin mahaifa.

Likita ya sake jaddada yin hysteroscopy, amma "gwaji" gwaje-gwaje wajibi ne don wannan aikin. Don yin wannan, an umurce ni da farko kyandirori, sannan kuma - lokacin da na sake ziyartar likita, wani ƙwayar rigakafi.

Likitan ilimin likitan mata ya fara ba da kyandir Fluomizinum.

Amma lura da su, kodayake yana da kwanciyar hankali, bai inganta sakamakon smear ba, - a cewar likitan, ya kara yin muni.

A matsayina na likitan mata, ban san abin da ta jagorance ta ba - bayan komai, bani da wani kumburi sakamakon duban dan tayi - ta wajabta mafi kyawun maganin ƙwararrun ƙwayoyin cuta - Avelox.

Na tabbatar min da cewa "lalle zai taimaka nan take!", bugu da presari yana ba ni ƙarin magunguna da yawa waɗanda zasu hana bayyanar dysbiosis da murƙushewa.

Gaba ɗaya, magani na ya biya dinari!

Kafin shan tururuwa Ni, kamar yadda na saba, karanta sake dubawa, daga abin da ya zama a bayyane cewa jikina yana da wuya canja wurin Avelox, kamar yadda Ina da matsaloli tare da gall mafitsara, kumawannan yana nufinkusan dukkanin cututtuka suna taimakawa.

Aikace-aikacen

Na ɗauki kwamfutar hannu na Avelox 1 a rana bayan abinci, wanke shi da ruwa don makonni 2.

Na yi ƙoƙarin kada in canza lokacin cin abincin don babu nauyin da ba dole ba a jiki.

Alamu

Cututtukan cututtuka da kumburi da tsofaffi ke haifar da ƙwayoyin cuta wanda ke haifar da ƙwayar cuta: m sinusitis, ciwon huhu na hanji na al'umma (gami da cututtukan ƙwayar cuta da ke haifar da ƙwaƙwalwar ƙwayar cuta da yawa), haɓakar ƙwaƙwalwar ƙwayar cuta, cututtukan da ba a daidaita su ba na fata da kyallen takarda mai taushi, cututtukan rikitarwa na fata da subcutaneous Tsarin (ciki har da ƙafar mai ciwon sukari), rikitarwa na ciki-ciki, ciki har da cututtukan polymicrobial, ciki har da kashin ciki na ciki, cututtukan mahaifa da ba a canzawa ba na gabobin pelvic (wanda ya hada da salpingitis da endometritis).

Contraindications

ciki, lactation (shayarwa),
yara da matasa 'yan ƙasa da shekara 18,
hypersensitivity to moxifloxacin da sauran abubuwan maganin.

Side effects

Haɓaka tazara ta QT (sau da yawa a cikin marasa lafiya tare da hypokalemia concomitant, wani lokacin a cikin wasu marasa lafiya), tachycardia da vasodilation (fulawa da fuska), jijiyoyin jini, hauhawar jini, fainting, achricular tachyarrhythmias, nonspecific arrhythmias (gami da karin wararrin silsila), poly (nau'in ƙwaƙwalwar ƙwayar cuta na ventricular pirouette) ko kamawar zuciya mafi mahimmanci a cikin mutane masu yanayin da ke haifar da yanayin arrhythmias, irin su bradycardia mai mahimmanci a cikin asibiti, m iskaria na myocardial, gajeriyar numfashi, gami da ac ilimin lissafi, tashin zuciya, amai, ciwon ciki, zawo, anorexia, maƙarƙashiya, dyspepsia, flatulence, gastroenteritis (ban da ciwan gastroenteritis), stomatitis, pseudomembranous colitis (a lokuta mafi ƙarancin alaƙa da ke tattare da rikice-rikice na rayuwa), cutuka, cututtukan hepatitis (musamman cholestate ), farin ciki, ciwon kai, rikicewa, disorientation, nutsuwa, rawar jiki, tashin hankali barci, tashin hankali, kara yawan psychomotor aiki, nakasa daidaituwa (ciki har da gawar hargitsi saboda dizziness Ni, a cikin mafi yawan lokuta mafi wuya, wanda ke haifar da raunin da ya faru a sakamakon faduwa, musamman a cikin tsofaffi marasa lafiya), fama da rauni a jiki tare da bayyananniyar asibitoci (ciki har da tashin hankali na mummunan mal), raunin hankali, raunin magana, tashin hankali, rashin jin daɗi (a lokuta mafi wuya, hali tare da halayyar cutar da kai zai yuwu), abubuwan da ba a sani ba, halayen psychotic (yiwuwar bayyanar cikin halayyar cutarwa da kansu), rikicewar dandano, rikicewar gani (blur, rage ƙarancin gani na gani, diplopia, musamman a hade tare da jin haushi da rikicewa, tinnitus, ƙetare ƙanshi, ciki har da ƙonewa, asarar dandano mai ƙanshi, anemia, leukopenia (gami da neutropenia), thrombosis cytopenia, thrombocytosis, tsawan lokaci na prothrombin kuma rage INR, arthralgia, myalgia, tendonitis, kara sautin tsoka da jijiyoyin jiki, lalacewar jijiyoyi, mamayar fitsari, fitsarin cuta, rashin ruwa (lalacewa ta hanyar gudawa ko rage ruwa ruwa), gazawar koda, gazawar renal sakamakon rashin aiki na koda , wanda zai iya haifar da lalacewar koda (musamman ma a cikin tsofaffi marasa lafiya da ke fama da rauni na ƙarancin ƙwayar cuta), halayen fata mai ban tsoro, alal misali, cutar Stevens-Johnson ko mai guba epidermal necrolysis (yiwuwar barazanar rayuwa), urticaria, pruritus, rash, eosinophilia, halayen anaphylactic / anaphylactoid, angioedema, gami da laryngeal edema (yiwuwar barazanar rayuwa), girgiza anaphylactic (gami da ƙari) barazanar rayuwa), zazzabin cizon saƙo (haɗe da alamu na rashin lafiyar, rashin jin daɗin ciwo da ɗumi), kumburi.

Abun ciki

Abunda yake aiki: moxifloxacin hydrochloride - 436.8 mg

Bayyanar

Allunan, kamar yadda kake gani, sun fi girma girma, amma godiya ga siffar elongated su suna shan bugu koyaushe.

Form sashi

400 MG allunan da aka saka a fim

Tabletaya daga cikin kwamfutar hannu ya ƙunshi

akabu mai aiki - moxifloxacin hydrochloride 436.8 mg,

(daidai yake da moxifloxacin 400.0 mg),

magabata: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate,

harsashi abun da ke ciki: baƙin ƙarfe baƙin ƙarfe ja, hypromellose, macrogol 4000, titanium dioxide.

Gilashin masu launin ja masu launin ja, mai kauri, kusan 17 mm tsayi da kusan 7 mm fadi, alama ce "M 400" a gefe guda kuma "BAYER" a daya gefen.

Kayan magunguna

Pharmacokinetics

Tsotsa da bioavailability

Lokacin da aka sha shi da baki, moxifloxacin yana shanshi cikin sauri kuma kusan gaba ɗaya. Cikakken bayanin bioavailability kusan kashi 91%.

Magungunan magani na moxifloxacin lokacin da aka karɓa a kashi 50 zuwa 1200 mg sau ɗaya, kazalika da 600 mg / rana tsawon kwana 10, layi ne. An cimma matsayin daidaituwa tsakanin kwanaki 3.

Bayan kashi ɗaya na 400 MG na moxifloxacin, mafi girman maida hankali (C max) a cikin jini an kai shi cikin awa 0.5-4 kuma shine 3.1 mg / l. Akarancin mafi girma da ƙananan ƙwayar cutar plasma a cikin yanayin tabbatacce (400 mg sau ɗaya kowace rana) sun kasance 3.2 da 0.6 mg / L, bi da bi.

Lokacin ɗaukar moxifloxacin tare da abinci, akwai ƙaramin haɓaka a cikin lokaci don isa zuwa Cmax (da awa 2) da ƙananan raguwa a Cmax (kusan kashi 16%), yayin da tsawon lokacin sha bai canza ba. Koyaya, waɗannan bayanan basu da mahimmanci na asibiti, tunda ƙimar AUC / MIC sun fi hasashen ayyukan antimicrobial na quinolones. Sabili da haka, ana iya amfani da miyagun ƙwayoyi ba tare da la'akari da abincin ba.

Moxifloxacin an rarraba shi da sauri cikin gado. Akwai babban yanki a ƙarƙashin sahun likitancin Afirka na AUC (AUCnorm = 6 kg * hours / L) tare da ƙimar rarrabuwa (Vss) na moxifloxacin na kusan 2 L / kg. Matsayi mafi girma na moxifloxacin a cikin yau yana da girma fiye da na plasma. A cikin in vitro da kuma cikin vivo karatu a cikin maida hankali kewayon daga 0.02 zuwa 2 ml / l, ɗaukar moxifloxacin zuwa sunadarai kusan 45%, ba tare da la'akari da yawan ƙwayar ba.

Moxifloxacin yana da alaƙa da yawancin albumin plasma.

Akwai babban kololuwa a cikin maida hankali kyauta> 10xMIC saboda karancin girma.

Babban magungunan ƙwayoyi, wanda ya wuce waɗanda ke cikin plasma, an halitta su a cikin ƙwayar huhu (ƙwayar epithelial, alveolar macrophages, ƙwayar halittar halittu), a cikin sinuses da polyps, a cikin ci gaba na kumburi. A cikin ƙwayar cuta, ƙwayar cuta mai shiga tsakani (intermuscular da subcutaneous), an ƙaddara babban taro na miyagun ƙwayoyi a cikin yanayin kyauta.

Bugu da kari, an tsaida manyan magungunan a jikin gabobin ciki da na cikin mahaifa, da kuma gabobin mace.

Bayan guda ɗaya na moxifloxacin 400 MG, a duka hanyoyin biyu na gudanarwa, an lura da iyakar mafi girman idan aka kwatanta da ƙwaƙwalwar ƙwayar plasma a cikin nau'ikan ƙwayoyin cuta masu manufa.

Bayan wucewar kashi na 2 na biotransformation, moxifloxacin yana keɓancewa daga jiki ta hanjin kodan da jijiyoyin ciki (GIT) duka biyu ba su canzawa ba kuma a cikin yanayin ƙwayoyin sulfo marasa aiki (M1) da glucuronides (M2). Waɗannan metabolites suna aiki kawai ga jikin ɗan adam kuma basu da aikin antimicrobial. Binciken hulɗa da magungunan metabolic tare da wasu kwayoyi ya nuna cewa moxifloxacin ba biotransformed ɗin ta hanyar tsarin microsomal cytochrome P450 ba.

Ko da ta hanyar hanyar aikace-aikace, ana samun metabolites M1 da M2 a cikin jini na plasma a maida hankali ƙasa da maida hankali akan moxifloxacin da ba'a canzawa ba.

Rabin rayuwar miyagun ƙwayoyi daga plasma shine kimanin awanni 12. Matsakaicin wadatarwa bayan shan kashi na 400 MG shine daga 179 zuwa 246 ml / min. Tabbatar da azabtarwa kusan 24-53 ml / min yana faruwa ta hanyar mabuɗar tubular reabsorption na miyagun ƙwayoyi a cikin kodan. Haɗewar yin amfani da ranitidine da probenecid baya tasiri akan maganin ƙwayar cutar koda. Ko da ta hanyar gudanarwa, farawa abu moxifloxacin kusan kusan 96-98% metabolized ne ga metabolites na kashi na biyu na metabolism ba tare da alamun oxidative metabolism ba.

Pharmacokinetics a cikin kungiyoyin haƙuri daban-daban

Ba a kafa bambance-bambance a cikin kantin magani na moxifloxacin ba.

Paul An bayyana bambance-bambance (33%) a cikin kantin magunguna (AUC, Cmax) tsakanin maza da mata. An bayyana bambance-bambance a cikin AUC da Cmax ta bambance-bambance a cikin nauyin jiki fiye da jinsi. Don haka, basu da mahimmanci a asibiti.

An yi nazarin bambance-bambance masu rikitarwa a cikin Caucasoid, Jafananci, Negroid, da sauran kabilu. Ba a tabbatar da bambance-bambance na musamman a cikin magungunan likita na moxifloxacin ba.

Ba a yi nazarin magungunan magungunan moxifloxacin a cikin yara ba.

Babu wasu canje-canje masu mahimmanci a cikin pharmacokinetics na moxifloxacin a cikin marasa lafiya da ke fama da rauni na aikin koda (ciki har da marasa lafiya tare da keɓancewar creatinine na 1/100 da 1/1000 da 1/10 0000 da 1 / 1,000)

- canji a cikin taro na thromboplastin

- anaphylactic / anaphylactoid reactions, rashin lafiyan / angioedema, gami da laryngeal edema (yiwuwar haɗarin rayuwa)

- Rashin tausayi, tabin hankali (a wasu lokuta mawuyacin hali, wanda ake iya nunawa a cikin hali tare da nuna lahani ga kansa, kamar tunanin kisan kai ko yunƙurin), abubuwan son rai

- hyposthesia, take hakkin wari, gami da cutar rashin ƙarfi

- mafarkai na cututtukan cuta, daidaituwa na daidaituwa (gami da rashi mara kyau, akasari saboda rauni ko vertigo (wanda ke haifar da raunin da ya faru, musamman a cikin tsofaffi marassa lafiya a cikin lokuta mafi wuya), rashi tare da bayyanar cututtuka na asibiti daban-daban (ciki har da na gaba ɗaya), mai rauni na hankali, matsalar magana, amnesia

- na gefe na neuropathy da polyneuropathy

- tinnitus, rashin jin magana, gami da kururuwa (galibi ana juyawa)

- fainting, hypotension, hauhawar jini, ventricular tachyarrhythmias

- dysphagia, stomatitis, pseudomembranous colitis (alaƙa da rikice-rikicen rayuwa mai haɗari sosai a lokuta), jaundice, hepatitis (yafi na cholestatic)

- tendonitis, ƙara yawan sautin tsoka da raunin ƙwayar tsoka, rauni na tsoka

- lalacewar aikin na koda, gazawar koda (sakamakon rashin ruwa, musamman a cikin tsofaffi marassa lafiya da ke fama da rauni na koda)

Formaddamar da tsari da abun da ke ciki

Avelox yana samuwa a cikin nau'ikan allunan da aka rufe da kuma maganin jiko.

Abubuwan da ke aiki shine moxifloxacin: a cikin kwamfutar hannu 1 da 250 ml na bayani - 400 MG.

Fitattun allunan: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hypromellose, baƙin ƙarfe baƙin ƙarfe, macrogol 4000, dioxide titanium.

Abubuwan taimako na maganin: 1M hydrochloric acid, sodium chloride, 2M sodium hydroxide bayani, ruwa don allura.

Pharmacodynamics

Moxifloxacin (sunan sunadarai - 8-methoxyfluoroquinolone) babban wakili ne na kwayan cuta na kashe kwayoyin cuta. Sakamakon ƙwayar ƙwayar cuta tasa saboda gaskiyar cewa yana hana mai topoisomerases na ƙwayar cuta II da IV. Wannan yana haifar da rikice-rikice a cikin ayyukan rikodin, gyarawa da kwafin kwayar halitta na DNA na sel halittar kuma, sakamakon haka, yana haifar da mutuwar ƙarshen.

Imumaramin maida hankali na ƙwayoyin cuta na moxifloxacin duka ana iya kwatanta su da ƙanƙantar da hankali na inhibitory. Ba a ƙayyade aikin hana ƙwayoyin cuta na Avelox ta hanyoyin da ke haifar da haɓakar tsayayya da tetracyclines, penicillins, macrolides, aminoglycosides da cephalosporins. Ba a gano juriya tsakanin wadannan kungiyoyin antibacterial kwayoyi da moxifloxacin ba. Ba a yin rijistar matsalolin juriya na plasmid a halin yanzu ba. Matsakaicin yawan aukuwar juriya yana da ƙanƙanta sosai (10 -7 ‒10 -10).

Resistancewar Avelox yakan samu tsawan lokaci mai tsawo ta hanyar maye gurbi.

Maimaitawa fallasa zuwa ga kayan aiki na Avelox a cikin haɗuwa waɗanda ba su kai darajar ƙima mafi ƙarancin inhibitory (MIC) ba, yana haifar da kawai ƙara ƙima a cikin MIC.

Akwai maganganun giciye-tsayayya zuwa quinolones. Koyaya, wasu kwayoyin halittar anaerobic da gram-tabbatacce microorganisms masu tsayayya da sauran quinolones suna nuna kwarewar moxifloxacin.

An tabbatar da cewa additionarin metungiyar methoxy da aka sarrafa a wuri C8 zuwa tsarin kwayoyin moxifloxacin yana kara ayyukanta kuma yana hana haɓakar ƙwayoyin ƙwayar cuta mai inganci.

Additionarin rukuni na bikcloamine zuwa kwayar halitta a matsayi C7 yana hana ƙirƙirar efflux mai aiki da tsarin juriya ga fluoroquinolones.

In vitro moxifloxacin yana aiki ne da yawan ƙwayoyin gram-tabbatacce da kuma gram-korau, anaerobes, atypical da acid-resistant microorganisms (misali Legionella spp., Chlamydia spp., Mycoplasma spp.), Hakanan microorganisms masu tsayayya da macrolide da maganin β-lactam.

A yanzu, karatun biyu tare da masu sa kai an san su wanda canje-canje a cikin microflora na hanji bayan an yi nazari akan maganin moxifloxacin. Sun nuna raguwa a cikin tattarawar Klebsiella spp., Escherichia coli, Enterococcus spp., Bacteroides vulgates, Bacillus spp., Kazalika anaerobes Peptostreptococcus spp., Eubacterium spp., Bifidobacterium spp. Wadannan canje-canjen an sake juyawa don makonni biyu. Ba a gano mai cutar Clostridium mai rarraba abinci ba

A cikin vitro moxifloxacin yana nuna babban aikin ƙwayoyin cuta a cikin ƙananan ƙwayoyin cuta:

Kwayoyin cuta na ƙwayar cuta na ƙwayar cuta: Gardnerella vaginalis, methicillin-damuwa raunin coagulase-korau staphylococci (S. simulans, S. cohnii, S. saprophyticus, S. epidermidis, S. epidermidis, S.hominis, S. haemolyticus), Staphylococcus aureus (damuwa da ke nuna jijiyoyin jiki ga methicillin), cututtukan huhun ciki da suka hada da cututtukan dake magance penicillin, da kuma cututtukan da suke jure kwayar cutar kwaya dayawa, da kuma cutuka wadanda suke yin tsayayya wa rigakafi biyu ko fiye, wadanda suka hada da trimethoprim / sulfamethoxazole, penicillin (MIC fiye da 2 μg / ml), tetracyclines, cephalosporins na biyu (misali cefuroxime), macrolides, dtgalactiae naptoptocccus, Streptococcus pyrogenes vita vitatat, kamar yadda aka yi amfani da su. , S. thermophilus, S. mutans, S. sa livarius, S. sanguinis, S. mitis), kungiyar kungiyar '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' '' ('300') ita ce;
ƙwayoyin cuta na gram-korau: Proteus vulgaris, Haemophilus parainfluenzae, Haemophilus mura (har da nau'in roba da ba a samar da β-lactamases), Acinetobacter baumannii, Moraxella catarrhalis (gami da nau'ikan da ke haifar da rashin samar da β-lactamases, Bordella Ponia, Pordella Ponia
microorganisms anaerobic: Propionibacterium spp., Fusobacterium spp., Prevotella spp., Porphyromonas spp.,
microorganism na ƙwayar cuta: Coxiella burnetii, Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma huhu.

Abubuwa masu zuwa suna da hankali sosai ga moxifloxacin:

kwayoyin gram-tabbatacce: Enterococcus faecium, Enterococcus avium, Enterococcus faecalis (na musamman nau'in kula ne da ke tattare da keɓaɓɓen ƙwayar mara lafiya)
kwayoyin gram-korau: Providencia spp. (P. stuartii, P. rettgeri), Escherichia coli, Neisseria gonorrhoeae, Klebsiella oxytoca, Klebsiella pneumoniae, Morganella morganii, Citrobacter freundii, Proteus mirabilis, Enterobacter spp. (E. sanyazakii, E. intermedius, E. aerogenes), Enterobacter cloacae, Stenotrophomonas maltophilia, Burkholderia cepacia, Flurescas na Pseudomonas, Panoudomonas,
ƙananan ƙwayoyin cuta anaerobic: Clostridium spp., Peptostreptococcus spp., Bacteroides spp. (B. vulgaris, B. fragilis, B. uniformis, B. distasonis, B. ovatus, B. thetaiotaomicron).

Abubuwa masu zuwa sun nuna juriya ga miyagun ƙwayoyi:

kwayoyin gram-tabbatacce: methicillin-resistant resins of coagulase-korau staphylococci (S. simulans, S. cohnii, S. saprophyticus, S. epidermidis, S. hominis, S. haemolyticus), ofloxacin / methicillin-resistant resins of staphylococcus aureus,
kwayoyin gram-korau: Pseudomonas aeruginosa.

Ba'a bada shawarar amfani da Avelox wajen magance cututtukan cututtukan da ke haifar da cututtukan staphylococcus aureus tare da tabbacin juriya ga methicillin (MRSA). Idan mai yiwuwa ne ko kuma cututtukan da aka tabbatar da cutar ta hanyar MRSA, za a iya sanya magani tare da magungunan ƙwayoyin cuta masu dacewa.

Ga wasu ɓarnar, juriya na iya yaduwa daban da na lokaci kuma ya dogara da yanayin ƙasa na marasa lafiya. A saboda wannan dalili, lokacin da aka gwada ƙimar jijiya, ana ba da shawarar yin nazarin bayanan gida game da juriya, musamman don magance cututtukan cututtukan fata.

Idan a cikin marasa lafiya ana bi da su a asibiti, ƙimar yankin a ƙarƙashin likitan magunguna "taro - lokaci" (AUC) / MIC₉₀ ya fi 125, kuma mafi girman abun ciki na moxifloxacin a cikin jini (C.)_max) / MIC₉₀ yana cikin kewayon 8-10, wannan yana nufin tsinkaya mai dacewa da haɓaka asibiti na haƙuri. A cikin marasa lafiya, waɗannan alamun suna yawanci ba su da ƙasa (AUC / MIC₉₀ ya wuce 30-40).

Lokacin ɗaukar nau'in baka na Avelox: tare da matsakaicin MIC₉₀ 0.125 mg / ml AUIC (yanki a ƙarƙashin saɓin inhibitory, i.e. AUC / MIC rabo₉₀) daidai yake da 279, da C_max/ MIC₉₀ - 23.6. Tare da dabi'un MIC₉₀ 0.25 mg / ml da 0.5 mg / ml AUIC da dabi'u C_max/ MIC₉₀ sune biyun 140 da 11.8 a shari’ar farko da kuma 70 da 5.9 a shari’ar ta biyu.

Tare da jiko na ciki: tare da matsakaicin MIC₉₀ 0.125 mg / ml AUIC shine 313 da C_max/ MIC₉₀ - 32.5. Tare da dabi'un MIC₉₀ 0.25 mg / ml da 0.5 mg / ml AUIC da dabi'u C_max/ MIC₉₀ daidai da 156 da 16.2 a farkon shari’ar kuma 78 da 8.1 a shari’ar ta biyu.

Pharmacokinetics

Lokacin ɗaukar Avelox a ciki, moxifloxacin yana tunawa da babban gudu kuma kusan gaba ɗaya. Cikakken bayanin halittunsa kusan kashi 91%. An tabbatar da cewa Pharmacokinetics na wannan abu tare da kashi ɗaya a cikin kewayon 50-1200 MG, kazalika da kashi na Avelox a cikin adadin yau da kullun na 600 MG na kwanaki 10, layi ne. An kafa jihar daidaitawa tsakanin kwana 3.

Bayan kashi ɗaya na 400 MG na Avelox, an sami mafi girman yawan hankali a cikin jini a cikin awa 0.5-4 kuma shine 3.1 mg / l. Tare da gudanar da maganin baka na 400 MG na miyagun ƙwayoyi sau ɗaya a rana, matsakaicin mafi ƙarancin abubuwan da ke cikin jini sune 3.2 mg / L da 0.6 mg / L, bi da bi. Lokacin da moxifloxacin ya shiga ciki tare da abinci, akwai karuwa mai ƙaranci a cikin lokacin don isa zuwa mafi girman maida hankali (kimanin awa 2) da raguwa kaɗan a cikin mafi girman maida hankali (kusan 16%). A wannan halin, tsawon lokacin sha yana canzawa. Koyaya, waɗannan bayanan ba su da takamaiman mahimmanci na asibiti, saboda haka Avelox ya halatta don amfani ko da kuwa yawan abincin.

Bayan jiko guda na Avelox a kashi na 400 MG na 1 awa, mafi girman maida hankali na kayan ya kai ƙarshen jiko kuma yana kusan 4.1 mg / l, wanda ya dace da haɓakar kusan 26% idan aka kwatanta da darajar wannan sigar tare da gudanar da maganin moxifloxacin.

Fitar moxifloxacin, wanda mai ƙididdigar AUC ya ƙaddara, ya ɗan fi ƙarfin gudanar da maganin moxifloxacin. Cikakken bayanin bioavailability kusan kashi 91%. Bayan maimaitawar infusions na Avelox a kashi na 400 MG mai ɗaukar 1 awa 1 lokaci ɗaya kowace rana, matsakaicin matsakaici da ƙananan abubuwan moxifloxacin a cikin jini sun bambanta a cikin kewayon 4.1-5.9 mg / l da 0.43-0.84 mg / l, bi da bi. Matsakaici mai daidaituwa na 4.4 mg / L an cimma shi a ƙarshen jiko.

An rarraba magungunan cikin sauri cikin gabobin da kyallen takarda. Matsayinsa na ɗaukar nauyin sunadarai na jini (galibi albumin) kusan kashi 45%. Volumeaukar rarraba ya kai kusan 2 l / kg.

Mahimmanci na moxifloxacin, wanda ya wuce waɗanda ke cikin jini na jini, ana ɗaukarsa a cikin ƙoshin mai kumburi (ƙyalƙyalin abun ciki idan akwai rauni na fata), ƙwayar huhu (gami da alveolar macrophages da ruwa mai guba), polyps hanci da sinuses (ethmoid da maxillary sinuses). A cikin ƙwayar tsoka da ƙwayar cuta ta ciki, ana aiki da kayan aiki na Avelox ta hanyar kyauta (ba tare da ɗaukar nauyin sunadarai ba) kuma a cikin babban taro fiye da na jini. Hakanan, ana samun babban matakin moxifloxacin a cikin kwayoyin halittar mace, da ruwa mai gudana da kasusuwa na gabobin ciki.

Moxifloxacin yana cikin ayyukan biotransformation na kashi na biyu kuma an keɓe shi daga jiki tare da fitsari da feces. Haka kuma, an samo shi duka a cikin hanyar da ba ta canzawa da kuma ta hanyar sulhunan sulfo (M1) da glucuronides (M2), waɗanda ba su da aikin magunguna.

Magungunan ba ya shiga cikin halayen ƙwayoyin cuta saboda haɗuwa da tsarin microsomal na cytochrome P₄₅₀. Plasma maida hankali ne na M1 da M2 metabolites suna ƙasa da na mahaifa iyaye. Sakamakon binciken da aka yi shi ya nuna cewa babu wani mummunan sakamako na waɗannan metabolites akan jiki dangane da haƙuri da amincin su.

Rabin rayuwar moxifloxacin shine kimanin awanni 12. A matsakaici, jimlar yarda bayan gudanar da magani a cikin kashi na 400 MG shine 179-246 l / min. Rashin izini ya kai 24-53 ml / min. Wannan yana tabbatar da juzu'in tubular m ɗin kayan.

Matsakaicin ma'aunin moxifloxacin da lokaci na 2 metabolites shine kusan kashi 96-98%, wanda ke tabbatar da rashin isowar metabolism. Kimanin kashi 22% na kaso ɗaya na Avelox (400 MG) an keɓance shi da canzawa a cikin fitsari, kuma kimanin 26% tare da feces.

Lokacin da ake nazarin kantin magunguna na moxifloxacin a cikin mara lafiyar maza da mata, ƙungiyar ta AUC da adadin mafi yawan adadin sun bambanta da kusan kashi 33%. Rashin kayan bai dogara da jinsi ba. Bambanci a cikin AUC da mafi yawan maida hankali suna yiwuwa saboda bambance-bambance a cikin nauyin jiki, ba jinsi ba, kuma ba su da wani mahimmanci na asibiti.

Ba a gano bambance-bambance masu mahimmanci a cikin magungunan magunguna na moxifloxacin a cikin marasa lafiya na shekaru daban-daban kuma suna da kabilu daban-daban. A halin yanzu ba a fahimci magungunan magungunan moxifloxacin a cikin yara ba.

A cikin marasa lafiya da ke fama da ciwon sikila na dindindin na wucin gadi akan yanayin rashin lafiyar ko ci gaba da rashin lafiyar hemodialysis, haka kuma a cikin marasa lafiya tare da nakasassu na renal (ciki har da marasa lafiya da CC kasa da 30 ml / min / 1.73 m 2), ba a gano canje-canje masu mahimmanci a cikin magungunan likitancin moxifloxacin ba. Babban bambance-bambance a cikin taro na moxifloxacin a cikin marasa lafiya da ke fama da rauni na hanta (azuzuwan A da B gwargwadon ma'aunin Yara-Pugh) idan aka kwatanta da marasa lafiya tare da aikin hanta na al'ada da masu sa kai na lafiya kuma ba su nan.

Alamu don amfani

Dangane da umarnin, an wajabta maganin Avelox 400 MG don:

Kwayoyin cutar cikin huhu da gabobin ENT,
Cutar ciki da ciki,
Cututtukan cututtukan cututtukan fata da fata.

Ayyukan ƙwaƙwalwar ajiyar sun bayyana ne dangane da tarin yawa-na gram-tabbataccen gram-korau na ƙwayoyin cuta, ƙwayoyin cuta masu tsayayya da maganin beta-lactam da ƙwayoyin macrolide, ƙwayoyin cuta masu lalata acid da nau'ikan ƙwayoyin cuta, da kuma ƙwayoyin cuta anaerobic waɗanda ke tsayayya da magani.

Contraindications

Jagororin don Avelox sun nuna cewa ba a yarda da amfani da shi a cikin cututtuka irin su pseudomembranous colitis da gazawar na koda. Haramun shan kwayoyi ne ga mata masu juna biyu da masu shayar da yara, yara ‘yan kasa da shekaru 18 da kuma wasu mutane da ba su yarda da kowane bangare na maganin ba. Musamman taka tsantsan wajibi ne lokacin da ake rubuta magani ga marasa lafiya da cututtukan cututtukan da ke cikin tsakiyar jijiya, suna ba da alama cewa kamuwa da cututtukan zuciya. Cututtuka kamar gazawar hanta, ischemia mai myocardial, bradycardia, hypokalemia suma suna zama dalilin yin taka tsantsan a wajan sadar da Aveloks.

Umarnin don amfani Avelox: hanya da sashi

Za'a iya ɗaukar ambulaf a kowane lokaci na rana, ba tare da la'akari da yawan abinci ba. Allunan an ƙone allunan, tunda ba za a iya keta mutuncin harsashi ba. Rabin rayuwar miyagun ƙwayoyi tsari ne mai tsawo, don haka ya isa ya sha maganin sau ɗaya a rana.

Maganin yau da kullun na Avelox shine 400 MG. Bayan kulawa ta baka, ana tunawa da miyagun ƙwayoyi da sauri kuma kusan gaba daya. Matsakaicin matakin magani a cikin jini bayan amfani guda ɗaya ana lura dashi bayan sa'o'i 0.5-4 daga lokacin gudanarwa. Samun ingantaccen matakin moxifloxacin plasma yana faruwa bayan kwana uku na amfani yau da kullun.

Ana aiwatar da maganin jiko a ko dai a farkon jiyya tare da kara tura haƙuri zuwa ga amfanin Avelox a allunan, ko kuma ana amfani dashi har sai an warke.

Dogaro da cutar, tsawon lokacin magani shine kwana 7-10.

Side effects

M halayen da ke faruwa da wuya isa, batun dokokin dosing. Avelox na iya haifar da mummunan tasirin masu zuwa:

Tashin zuciya, amai, ciwon ciki, dandano rashin lafiya, ciwon kai, zawo,
Rateara yawan zuciya, ciwon kirji, palpitations, hauhawar jini,
Dizzness, tashin hankali barci, ciki, damuwa, rikicewa, rauni gaba ɗaya,
Raunin baya, jin zafi a cikin tsokoki da gidajen abinci, tendovaginitis, jijiyoyin jiki,
Itching, fatar jiki,
Hyperglycemia, hauhawar jini, hauhawar jini,
Janar malaise, kumburi.

Yawan abin sama da ya kamata

A yanzu, akwai iyakataccen bayani game da yawan adadin kuɗin da aka samu na Avelox. Tare da amfani guda ɗaya na miyagun ƙwayoyi a cikin adadin har zuwa 1200 MG ko lokacin da aka saka shi a cikin allurai waɗanda ba su wuce 600 MG ba, ba a yi rikodin sakamako ba har tsawon kwanaki 10.

Game da yawan abin sama da ya kamata, ya wajaba a bincika hoto na asibiti game da yanayin mai haƙuri kuma a tsara maganin tallafawa alamu a hade tare da saka idanu na ECG.

Yawan cin carbon da aka kunna nan da nan bayan maganin na moxifloxacin ga jikin mutum yakan taimaka wajen gujewa wuce gona da irin kwayar cutar ta shan kwayoyi idan sun sha kwaya.

Umarni na musamman

Idan jin zafi a cikin gidajen abinci ko jijiya lokacin shan Avelox, an soke maganin don hana katsewar jijiya.

A cikin marasa lafiya da ke fama da cututtukan fata, Avelox na iya tayar da tashin hankali.

Tare da haɓakar cutar zazzabi mai zafi yayin ɗaukar Avelox, an soke ta.

Abincin antacids da enterosorbents, kazalika da kwayoyi waɗanda suka haɗa da baƙin ƙarfe, aluminium da magnesium ya kamata ya faru a lokuta daban-daban tare da Avelox, bambanci ya kamata aƙalla 4 hours.

Ba a yi amfani da Avelox wajen yi wa yara.

Tasiri a kan ikon tuka motoci da abubuwa masu rikitarwa

Yin amfani da Avelox na iya haifar da matsaloli a cikin marasa lafiya yayin tuki motoci da yin wasu nau'ikan haɗari masu haɗari waɗanda ke buƙatar haɓaka taro da halayen psychomotor nan da nan, wanda ya faru ne sakamakon takamaiman sakamako masu illa na miyagun ƙwayoyi (raunin gani, tasirin mummuna akan tsarin juyayi na tsakiya).

Haihuwa da lactation

Tsaro na gudanarwar moxifloxacin yayin daukar ciki ba a kafa shi ba, saboda haka yin amfani da shi yana tazara. Akwai sanannun lokuta na lalacewa ta hanyar lalacewa a cikin yara masu ɗaukar wasu quinolones, amma ba a sami wannan tasirin a cikin tayi yayin jiyya tare da mata masu ciki daga Avelox.

Karatun dabbobi sun tabbatar da cutarwar haihuwar moxifloxacin. Dangane da mutane, har yanzu ba a fahimci yiwuwar haɗarin Avelox ba.

Moxifloxacin, kamar sauran quinolones, yana tsokanar lalacewar guban manyan gidajen abinci a cikin dabbobi da aka haife su da wuri. Karatuttukan karatu na farko sun nuna cewa moxifloxacin, a cikin karamin maida hankali, ya shiga cikin madarar nono. Ba a samun bayani game da amfani da shi a cikin marasa lafiya yayin shayarwa, don haka amfani da shi yayin shayar da jarirai yana da sabani.

Tsarin saki, abun da aka shirya da shiryashi

Apoks mai rufi allunan:

Kwamfutar hannu 1 ta ƙunshi moxifloxacin (a cikin nau'in hydrochloride) - 400 MG
a cikin akwatin 1 blister don 5 ko 7 inji., ko a cikin akwati 2 blisters don 5 inji mai kwakwalwa.

Matsalar jiko na tsibbu:

Kwalbar 1 ta ƙunshi moxifloxacin (a cikin nau'in hydrochloride) - 400 MG
sauran kayan abinci: sodium chloride, sodium hydroxide, hydrochloric acid, ruwa d / da.
Kwalban 250 ml -1 a cikin akwati.

Matsalar jiko na tsibbu:

Fakiti 1 ya ƙunshi moxifloxacin (a cikin nau'in hydrochloride) - 400 MG
sauran sinadaran: sodium chloride, sodium hydroxide, hydrochloric acid, ruwa d / da.
250 ml - polyolefin jakunkuna (1) - jakunkuna na filastik an cika su tare da tsare (12) a cikin akwati.

Aikin magunguna

Moxifloxacin magani ne na kwayan cuta na kwayan cuta wanda ke dauke da kwayoyi masu yawa wadanda suke aiwatar da jerin cututtukan fluoroquinolone. Sakamakon ƙwayar ƙwayar cuta ta hanyar ƙwayar cuta shine saboda hanawar ƙwayoyin topoisomerases na II da IV, wanda ke haifar da cin zarafin biosynthesis na DNA na ƙwayar microbial kuma, a sakamakon haka, ga mutuwar ƙwayoyin ƙwayoyin cuta. Imumarancin ƙananan ƙwayoyin cuta na ƙwayar cuta suna kamantawa da mafi ƙarancin ƙwaƙwalwar inhibitory.

Hanyoyin da ke haifar da ci gaban juriya ga maganin penicillins, cephalosporins, aminoglycosides, macrolides da tetracyclines ba su keta ayyukan antibacterial na moxifloxacin.Babu juriya tsakanin-wadannan kungiyoyi na kwayoyi masu kashe kwayoyin cuta da moxifloxacin. Ya zuwa yanzu, har ila yau, ba a sami maganganun juriya na plasmid ba. Matsakaicin ƙarfin haɓakar juriya kaɗan ne (10 7 - 10 10). Moxifloxacin juriya yana tasowa ne sannu a hankali ta hanyar rikida abubuwa masu yawa. Maimaitawa na moxifloxacin zuwa microorganisms a cikin maida hankali a ƙasa da ƙaramin inhibitory maida hankali (MIC) yana haɗuwa tare da ƙaramin ƙaruwa a cikin MIC. Akwai lamunin giciye-tsayayya ga quinolones. Koda yake, wasu kwayoyin-gram-tabbatacce kuma anaerobic microorganisms masu tsayayya da sauran quinolones suna kula da moxifloxacin.

In vitro moxifloxacin yana aiki da dumbin-gram-korau da gram-tabbatacce microorganisms, anaerobes, kwayoyin acid masu jurewa da nau'ikan cututtukan daji, irin su Mycoplasma, Chlamidia, Legionella, harma da kwayoyin cuta masu jure to-lactam da maganin rigakafi.

Me ke taimaka wa Avelox?

Babban alamomi game da nadin Avelox sune yanayin / cututtuka masu zuwa:

Kwayoyin cutar cikin huhu da gabobin ENT,
Cutar ciki da ciki,
Cututtukan cututtukan cututtukan fata da fata.

Ciki

Amincin yin amfani da moxifloxacin lokacin daukar ciki ba a kafa shi ba kuma an hana yin amfani da shi. An bayyana yanayin lalacewar lalacewar lalacewar yara a cikin yaran da ke karɓar wasu quinolones, duk da haka, bayyanar da wannan tasirin a cikin tayin (lokacin da mahaifiyar tayi amfani da shi a lokacin daukar ciki).

Nazarin dabbobi sun nuna yawan guba. Ba a san yiwuwar haɗarin ga mutane ba.

Kamar sauran quinolones, moxifloxacin yana haifar da lalata lalatattun manyan gidajen abinci a cikin dabbobi da suka girma. Karatuttukan bincike na farko sun gano cewa karamin adadin moxifloxacin an kebe shi a cikin madara. Ba'a samun bayanai game da amfanin sa a cikin mata yayin shayarwa. Sabili da haka, alƙawarin moxifloxacin yayin shayarwa yana da sabani.

Hulɗa da ƙwayoyi

Tare da haɗuwa da moxifloxacin tare da probenecid (ba a tabbatar da mahimmancin hulɗar asibiti tare da abubuwan da ke aiki na Avelox ba), atenolol, morphine, ranitidine, digoxin, itraconazole, abubuwan da ke ƙunshe da ƙwayoyin jini, glibenclamide, theophylline, maganin hana haihuwa, ba lallai ba ne.

Tare da yin amfani da Avelox da magungunan da suka shafi tsawan tazara na QT, ana iya lura da ƙarin tasirin tazara na Qt. Tare da haɗuwa da moxifloxacin da kwayoyi masu kama, haɗarin haɓakar arrhythmias, ciki har da polymorphic ventricular tachycardia (torsade de pointes), yana ƙaruwa.

Co-of moxifloxacin da kwayoyi masu zuwa wadanda suka shafi tsawan tazara na QT an contraindicated:

antihistamines (misolastine, astemizole, terfenadine),
aji IA antiarrhythmic kwayoyi (biyun rashin jituwa, hydroquinidine, quinidine, da sauransu),
kwalejin III na antiarrhythmic (ibutilide, amiodarone, dofetilide, sotalol, da sauransu),
maganin rigakafi na rigakafi, musamman halofantrine, sparfloxacin, pentamidine, erythromycin (gudanarwar cikin jijiya),
tricyclic maganin rigakafin,
maganin tari (suloprid, phenothiazine, haloperidol, sertindole, pimozide, da sauransu),
wasu diphemanil, cisapride, bepridil, vincamine (gudanarwa na ciki).

Gudanarwa na Avelox na lokaci guda tare da multivitamins, ma'adanai da maganin antacids na iya haifar da lalacewar moxifloxacin saboda samuwar cukudu masu hade da cations masu yawa waɗanda ke cikin waɗannan kwayoyi. Sakamakon haka, matakin moxifloxacin a cikin jini na plasma na iya zama ƙasa da ƙima da muhimmanci. Saboda haka, maganin rigakafi (misali, didanosine) da shirye-shiryen antacid da sauran magunguna waɗanda suka haɗa da aluminum ko magnesium, kazalika da sucralfate da sauran magunguna waɗanda ke ɗauke da zinc ko ƙarfe, ana bada shawarar a ɗauki su aƙwan sa'o'i 4 kafin ko 4 hours bayan na baka gwamnati na Avelox.

Tare da haɗuwa da Avelox tare da warfarin, lokacin prothrombin da sauran ma'auni na coagulation na jini ba su canzawa. A cikin marasa lafiya da aka bi da su tare da maganin anticoagulants a hade tare da maganin rigakafi, ana lura da kara yawan aikin anticoagulant na magungunan anticoagulant.

Abubuwan haɗari sun haɗa da yanayin gaba ɗaya da shekarun mai haƙuri, kazalika da kasancewar wani cuta mai kamuwa da cuta wanda ke tattare da ayyukan kumburi. Duk da gaskiyar cewa hulɗar moxifloxacin da warfarin ba a tabbatar da su ba har yau, marasa lafiya waɗanda ke shan magani tare da waɗannan kwayoyi ya kamata su sa ido a kai a kai cikin INR kuma, idan ya cancanta, haɓaka ko rage kashi na maganin rashin daidaituwa.

Digoxin da moxifloxacin kusan basa shafar ma'aunin magunguna na junan su. Tare da gabatarwar maimaita allurai na Avelox, mafi girman taro na digoxin ya karu da kusan 30%. A wannan yanayin, ƙaramin taro na digoxin da ƙimar yankin a ƙarƙashin murhun likitancin "maida hankali - lokaci" a zahiri bai canza ba.

Tare da gudanarwa na lokaci daya na moxifloxacin a kashi na 400 MG da kunna gawayi, tsari na bioavailability na Avelox yana raguwa da sama da 80% saboda hanawar shan shi. Game da yawan abin sama da ya wuce, amfani da carbon mai aiki a farkon matakin sha, yana hana kara haɓakawa cikin tsarin.

Analog na Avelox a cikin kayan aiki sune magungunan masu zuwa: Vigamox, Moximac, Moxin, Moxifloxacin, Moxifloxacin hydrochloride, Plevilox. Subungiyoyin magungunan guda ɗaya sun haɗa da: Abactal, Basigen, Gatispan, Geoflox, Zanocin, Xenaquin, Levoflox, Normax, Ofloxacin, Ciprofloxacin da sauransu.

Ra'ayoyi game da Aveloks

Reviews game da Avelox wanda masana suka bari suna da matukar rikitarwa. Wasu likitoci suna ɗaukar shi a matsayin ƙwaƙwalwa mai ƙarfi kuma ingantacciyar ƙwaƙwalwar ƙwayar cuta wanda ke taimakawa jure wa wakili na cututtukan cututtukan ƙwayar cuta kamar cututtukan daji, pyelonephritis, mura, SARS, da E. coli. Wasu kwararru sun ce kusan babu wani sakamako mai kyau da aka samu na maganin, amma sun lura da yawan sakamako masu illa.

Ra'ayoyin marasa lafiya game da Avelox kuma an cakuda su. Mutane da yawa suna ambaton irin wannan rashin sakamako na gefen rashin tausayi kamar rage cin abinci da tashin zuciya. Koyaya, yawancin marasa lafiya suna ɗaukar shi mai ƙarfi da ingantaccen ƙwayar ƙwayar cuta.

Abun ciki da nau'i na saki

Avelox yana samuwa a cikin nau'ikan allunan da kuma mafita don jiko (ba don allura ba). Gano kanka tare da abun da ke ciki, bayanin da taƙaitaccen bayanin magunguna:

Pink, matte, oblong, mai rufin fim.

M ruwa mai launin shuɗi-mai ruwan haske.

Yawan maida hankali ga moxifloxacin, mg

400 na kwalba 1

Titanium dioxide, microcrystalline cellulose, macrogol, sodium croscarmellose, jan ƙarfe baƙin ƙarfe, lactose monohydrate, hypromellose

Ruwa, sodium chloride, hydrochloric acid, sodium hydroxide bayani.

Blister na 5 ko 7 inji., Acksarin fakiti na 1 ko 2 blisters.

250 ml vials ko kwantena.

Sashi da gudanarwa

Likitoci sau da yawa suna rubuta ambulaf don angina, ƙurji, ciwon huhu, saboda tasirin ƙwayoyin cuta, ƙwayar ta kashe ƙwayoyin causative na kamuwa da cuta kuma yana sauƙaƙa kumburi. Hanyar aikace-aikacen, tsarin sashi da tsawon lokacin aikin jiyya sun dogara da nau'in, tsananin cutar da nau'in magani. Allunan ana daukarsu a baki, maganin shine parenteral, a cikin hanyar infusions.

Ana daukar ambulaf a cikin allunan a baki a 400 MG 1 lokaci / rana. Allunan ba su tauna ba, an wanke su da ruwa, komai abincin. A cikin tsufa, sashi ba ya canzawa. Tsawon lokacin jiyya ya dogara da cutar:

A hanya na lura a cikin kwanaki

Wucewar cutar mashako na kullum

Cutar cutar tarin fuka da al'umma ta haifar bayan kwayar cutar Avelox

Maganin jiko

Don amfani da cikin ciki, maganin maganin suna iri ɗaya a cikin kashi 400 MG sau ɗaya / rana an yi niyya. Magungunan kwayoyi suna kasancewa har zuwa kwanaki 21. Tare da ciwon huhu na al'umma, maganin yana wuce kwanaki 7-14, tare da rikitarwa masu rikitarwa - kwanakin 7-21, tare da kamuwa da ciki - 5-14 kwana. Ga tsofaffi da marasa lafiya da ke fama da cutar hanta, ashe baya canzawa.

Ana magance maganin matsalar a cikin awa daya. Za'a iya amfani da maganin tare da dilution tare da ruwa, Maganin Ringer, sodium chloride, dextrose ko xylitol. Kawai bayyananniyar mafita an gabatar da ita ba tare da rikicewa ba, barna. Bayan dilution tare da sauran ƙarfi, ƙwayar ta tabbata a cikin kullun, muddin an adana shi a zazzabi a ɗakin.

A lokacin daukar ciki

An kare lafiyar amfani da moxifloxacin lokacin daukar ciki, saboda haka amfani da shi ya kewaya. Nazarin cikin berayen sun nuna yawan guba. A cikin dabbobi, Moxifloxacin yana haifar da lahani ga katako na manyan gidajen abinci, wanda aka keɓe a cikin madarar nono, don haka kulawa tare da shayarwa ya kasance mai haɓaka.

A lokacin ƙuruciya

Ba za a iya yin amfani da ambulan a lokacin ƙuruciya da samari a ƙarƙashin shekaru 18. Wannan yana da alaƙa da haɓakar haɗarin aiki mai rauni na gidajen abinci da kuma guringuntsi. Yawancin watsawa ga kwayoyin rigakafi na iya haifar da guba, haɓakar rashes, tashin hankali da rashin damuwa na tsarin juyayi na tsakiya. Wannan yana da haɗari musamman yara da kuma tsakanin yaran makaranta.

Avelox da barasa

Don guje wa haɗarin yiwuwar rikicewar hanta, tsawon lokacin maganin Avelox, yakamata ka ƙi shan giya ko ƙwayoyi. Barasa amfani da giya yana rushe gabobin, yana haifar da yawan maye da yawan maye. Ethanol yana rage tasirin maganin, yana haifar da mummunan sakamako. Kuna iya ci gaba da shan ta wata guda bayan ƙarshen magani.

Sharuɗɗan sayarwa da ajiya

Ana siyar da yanar gizo ta hanyar sayen magani, adana shi a yanayin zafi har zuwa digiri 25 don allunan da kuma digiri 15-30 don bayani. Rayuwar shiryayye na allunan da vials na maganin shine shekaru biyar, mafita a cikin kwantena shine shekaru uku.

Kwayoyin halitta tare da kayan aiki guda ɗaya kuma suna maye gurbinsu tare da wani sashi, amma tare da tasirin tsari iri ɗaya, ana magana dasu zuwa analog ɗin Aveloks. Magungunan antimicrobial analogues:

Aquamox - mafita dangane da moxifloxacin,
Moxifluor asalinsu ne na maganin da ake tambaya,
Megaflox - Allunan tare da kayan aiki iri daya.
Hainemoks - shirye-shiryen kwamfutar hannu, analog kai tsaye,
Moxifloxacin shine mafi mashahuri maye gurbin magani.

Umarnin don amfani (Hanyar da sashi)

Allunan ana shan su ba tare da taunawa ko rarrabawa ba, ba tare da cin abincin ba.

Dangane da umarnin don Avelox 400 MG, ga manya, yawan maganin yau da kullun shine kwamfutar hannu ɗaya ko 400 mg na maganin rigakafi.

Ya kamata likitan da ke halartar likitan likitan mata ya tsai da tsawon lokacin da yanayin aiki, gwargwadon tsananin kamuwa da cuta, tasirinta da azanci na mai haƙuri.

A matsayinka na mai mulkin, a farkon jiyya, an wajabta magani a injections, to, bayan farkon ingantawa, ana iya tsara allunan.

Tare da wuce gona da iri na kullummashako hanya tare da magani tare da miyagun ƙwayoyi ne 5 kwana. A ciwon huhu - daga 7 (injections) zuwa kwana 10.

A m sinusitis da cututtukan da ba a daidaita su ba na fata da kyallen takarda, tsawon lokacin da ake sarrafa maganin sati daya ne.

Tare da cututtukan da ba a daidaita su ba na gabobin pelvic, hanyar kulawa shine makonni biyu.

Idan rikice-rikice masu rikitarwa na fata da tsarin a cikin fata, ana aiwatar da maganin a hankali ta hanyar da zai wuce daga kwanaki 5 zuwa makonni biyu.

A cikin mutanen da ke fama da rauni na aiki da hepatic, tsofaffi, da kuma ga kabilu daban-daban, ba a yin gyaran sashi.

Umarnin don amfani da Avelox don yin allura

Yi amfani da kawai bayyananne bayani, ba tare da hazo ko girgije ba.

Ana gudanar da miyagun ƙwayoyi a cikin jijiya na dogon lokaci, tsawon minti 60, aƙalla ba tare da dilution ba. Hakanan sau da yawa ana haɗa ƙwayoyin rigakafi tare da T adaftar tare da ruwa don yin allura maganin sodium chloride(0.9% ko 1M), mafita dextrose (5%, 10%, 40%), mafita xylitol 20%, mafita Ringer. Za'a adana cakuda da aka shirya za'a iya ajiye shi a zafin jiki a daki na 24.

A cikin sirinji iri ɗaya ko dropper, sauran wakilai ba su da gauraye.

Haɗa kai

Yana nufin da kyau tare da atenolol, theophylline, shirye-shiryen alli, ranitidine, maganin hana haihuwa, intraconazole, morphine, glibenclamide, digoxin, warfarin, probenecid.

Koyaya, idan aka haɗa tare da kai tsaye anticoagulants ya kamata a duba kuma a lokaci-lokaci a duba INRdaidai daidaita maganin maganin.

Idan aka hada shi da antacids, multivitamins an kuma samar da ma'adanai chezed hadaddun magunguna tare da cations na polyvalent, maida hankali kan ƙwayoyin rigakafi a cikin jini yana raguwa. Dangane da haka, ya kamata a lura da tazara tsakanin sa'o'i 4 tsakanin shan magungunan.

Idan kun hada magani tare da carbon mai aiki ko wasu enzamarska, sannan bioavailability na miyagun ƙwayoyi yana ragu sosai (kusan 80%). Tare da gudanarwa na ciki, wannan adadi ya kai 20%.

Maganin maganin jiko bai kamata a gudanar dashi tare da 10% da 20% sodium chloride, hydrogencarbonate sodium 4.2% da 8.4%.

Analogues na Tashin hankali

Mafi kusanci analogues na Takobin: Moxifloxacin-Farmex, Moxifloxacin, Moxifluor, Moflox, Moxifloxacin-Credofarm, Maxicin, Moxifluor 400, Moxin, Tevalox, Lupine Mofloxin.