Magungunan Atorvastatin: umarnin don amfani, tasirin sakamako da bita

Bayanin da ya dace da 26.01.2015

Sunan Latin: Atorvastatin
Lambar ATX: S10AA05
Aiki mai aiki: Gagarinka (Atorvastatinum)
Mai masana'anta: Magungunan CJSC ALSI

Tabletaya daga cikin kwamfutar hannu ya ƙunshi milligramms 21.70 ko 10.85 atorvastatin alli mai narkewa, wanda ya dace da milligram 20 ko 10 na atorvastatin.

A matsayin abubuwanda suka taimaka, Opadra II, magnesium stearate, aerosil, sitaci 1500, lactose, celclosese microcrystalline, carbonate carbonate.

Aikin magunguna

Wannan magani shine hypocholesterolemic - yana gasa da kuma zaɓi yana hana enzyme wanda ke sarrafa ƙimar sauya HMG-CoA zuwa mevalonate, wanda daga baya ya shiga cikin sterols, gami da cholesterol.

Raguwar ƙwayoyin plasma lipoproteins da cholesterol bayan ɗaukar miyagun ƙwayoyi ya kasance sakamakon raguwar aikin cholesterol a cikin hanta da kuma aikin HMG-CoA reductase, da haɓaka matakin masu karɓa na LDL a saman ƙwayoyin hanta, wanda ke ƙara haɓakawa da fatalwa na LDL.

A cikin mutane tare da homozygous da heterozygous familial hypercholesterolemia, cakuda dyslipidemia, da hypercholesterolemia marasa gado, raguwar apolipoprotein B, yawan ƙwayoyin cuta, da ƙananan ƙarancin cholesterol-lipoproteins yayin shan wannan magani.

Wannan magani yana rage damar haɓaka. ischemia da mace-mace a cikin mutane na kowane zamani da ciwon infarction na zuciya ba tare da tsayayyen angina da raunin Q ba.Yana kuma rage yawan hadarin rashin kamuwa da rauni mai yawan gaske, yawan cututtukan zuciya da hadarin kamuwa da cututtukan dabbobi masu cutarwa na zuciya da jijiyoyin jini.

Magunguna da magunguna

Yana da babban narkewa, ana lura da mafi girman hankali a cikin jini bayan daya zuwa awa biyu bayan gudanarwa. Amfani da bioavailability ya yi ƙasa saboda tsabtace tsarin aiki na ƙwayar ciki da kuma tasirin “hanyar farko ta hanta” - kashi 12 cikin ɗari. Kimanin kashi 98 na kashin da aka dauka yana daure ne da garkuwar plasma. Metabolization yana faruwa a cikin hanta tare da samuwar metabolites mai aiki da abubuwa marasa aiki. Rabin rayuwar shine awa 14. Yayin yanayin hemodialysis bai nuna ba.

Contraindications

Kada a sha maganin tare da:

a karkashin shekara 18
ciki da lokacin nono,
gazawar hanta,
cututtukan hanta na aiki ko haɓaka aikin enzymes na “hanta” saboda wasu dalilai marasa tushe,
rashin hankali ga abinda ke ciki na miyagun ƙwayoyi.

Ya kamata a ɗauka tare da cutar tsoka, raunin da ya farubabban tsarin aikin tiyata ba a sarrafa shi ba fargaba, sepsis, jijiyoyin jinirikicewar metabolism da endocrine, damuwa a cikin ma'aunin electrolyte na tsananin tsananin, tarihin cutar hanta da shan barasa.

Side effects

Lokacin shan waɗannan allunan, zaku iya dandana:

tashin hankali gout, mastodynianauyi riba (sosai m)
albuminuria yawan hailahawan jini (mai wuya)
petechiae, ecchymoses, seborrhea, eczemaswearin sweating, xeroderma, alopecia,
Cutar Lyell, cututtukan da suka yawaita erythema, daukar hoto, kumburi da fuska, angioedema, cututtukan mahaifa, tuntuɓar dermatitisfata fitsari da itching (rare),
take hakkin kawo rikici, rashin ƙarfi, rage libido, epididymitis, metrorrhagia, nephrourolithiasis, zubar farji, hematuria, fitar, dysuria,
haɗin gwiwa, tsoka, azabtarwarhabdomyolysis myalgiaarthralgia ciwon kai, anisitis, tendosynovitis, bursitisƙafafun kafafu amosanin gabbai,
gwanaye, goms na jini, melena, zubar jini na hanji, aikin hanta mai rauni, Jazzice cholestatic, maganin ciwon huhu, ciwon duodenal, cutar sankara, biliary colic, hepatitisgastroenteritis, ulcers na mucosa na baka, maƙarƙashiya, esophagitis, stomatitis, amaidysphagia binnewabushewar bakin ciki, haɓaka ko rage ci, ciwon ciki, na ciki, rashin tsoro, zawo ko maƙarƙashiya, ƙwannafi, tashin zuciya,
kumburin hanci, kumburin mahaifa, dyspnea, ciwon huhu, rhinitis, mashako,
thrombocytopenia, lymphadenopathy, anemia,
angina pectoris, arrhythmia, phlebitis, hauhawar jini, hauhawar jini, tashin zuciya, ciwon kirji,
asarar dandano, parosmia, glaucoma, kurma, bashin ciki, damuwa na masauki, bushewar haɗuwa, tinnitus, amblyopia,
asarar sanimaganin ciwan jiki bacin rai, migrainehyperkinesis, facial inna, ataxiadanshi mai danshi amnesiana gefe neuropathy, paresthesia, nasiha, nutsuwa, malaise, asthenia, ciwon kai, tsananin farin ciki, rashin bacci.

Haɗa kai

Gudanarwa na lokaci daya tare da masu hana masu kariya suna ƙara maida hankali ga abu mai aiki a cikin jini. Amfani da haɗin kai tare da kwayoyi waɗanda ke rage taro na kwayoyin steroid endogenous (ciki har da Spironolactone, Ketoconazole da Cimetidine) suna ƙara yiwuwar rage hodar iblis steroid.

Lokacin da aka ɗauka lokaci guda tare da nicotinic acid, erythromycin, fibrates da cyclosporins, yana ƙaruwa da yiwuwar haɓakar cutar kansa yayin da ake bi da wasu kwayoyi na wannan aji.

Simvastatin da Atorvastatin - Wanne ya fi kyau?

Simvastatin Statin halitta ce, kuma Atorvastatin shine mafi mahimmancin Statin zamani na asalin roba. Kodayake suna da hanyoyi na rayuwa daban-daban da kuma tsarin sunadarai, suna da sakamako iri iri. Su ma suna da tasirin sakamako guda ɗaya, amma Simvastatin yafi rahusa fiye da Atorvastatin, don haka ta hanyar farashin Simvastatin shine mafi kyawun zaɓi.

Formaddamar da tsari da abun da ke ciki

Atorvastatin yana samuwa a cikin nau'ikan allunan da aka saka a fim tare da babban sinadari mai aiki atorvastatin alli trihydrate.

Anyi amfani da abubuwa masu zuwa azaman kayan taimako a cikin shirye-shiryen: microcrystalline cellulose, kalisiomu carbonate, lactose, sillofon silicon dioxide, sitaci 1500, Opadry II, steneste magnesium, titanium dioxide, talc.

Nazarin ra'ayoyi mara kyau

Ni kuma ban lura da ci gaba ba, amma ciwon kai, tsananin farin ciki da kwanciyar hankali ya fara. Menene "Botany" ɗinmu zai fito tare don taimakawa mutane, kuma ba mataimakin ba))

An sanya shi don ɗaukar atorvastine tare da cholesterol 6. 5. Ina shan 10 MG a rana - Ban ga sakamako na musamman ba, amma akwai wadatattun sakamako masu illa. Ina kokarin canzawa zuwa tsarin abinci.

Ba zan iya cewa wannan magani yana da ban mamaki ba. An wajabta wa mahaifina a cikin kwatanci na 60 MG / rana, tun da ƙwayar cholesterol hali ne na gado a cikin danginmu.

dacewar liyafar (ba tare da la’akari da yawan abincin ba)

Ban lura da wasu canje-canje a kiwon lafiya a ƙarshen lokacin ba da magani ba. Yayinda kwalar ta fi 7 mmol / l, ta wanzu .. Bayan wata shida, kwafin mahaifinsa ya toshe ƙwayar tsotsar ƙwaƙwalwar ƙwayar cuta, wanda hakan ya tsoratar da ƙoshin yatsan babban yatsan. Yanzu, don guje wa yanki sau biyu a shekara, an koyar da iyaye da magunguna masu tsada sosai.

A ganina, atorvastatin magani ne mara amfani sosai, kuma ban san abin da likitocin suka tsara ba.

An tsara Mama Atorvastatin bayan bugun jini. Kafin wannan, mahaifiyata lokaci-lokaci tana shan magungunan kwalaji, amma dukkan su suna da tsada, sama da 1000r. A wannan yanayin, farashin ya yarda. Amma wannan shine kawai don mama.

Bayan watanni 3 na shan Atorvastatin, cholesterol bai ragu ba. A bango na shan magungunan, ciwon kai da tashin zuciya sun ci gaba. Abin lura ne cewa umarnin yana ɗauke da adadin manyan sakamako masu illa, haɗe da wannan magani ba da shawarar tsofaffi ba. Kuma mahaifiyata tsoho ce kawai. Haka ne, kuma babban cholesterol yafi rinjayar yawan mutane shekaru.

Sun nemi likita ya soke maganin, ba su yarda da mu ba, sun ce ya kamata su sha shi koyaushe, kuma ba su ce har yaushe. Don haka rikici tare da shi. Jiyya ba ta da dadi ko kaɗan, kuma babu wani jin cewa jiyya yana haifar da murmurewa.

da yawa sakamako masu illa

Ina so in yi magana game da ƙwarewa ɗaya mara dadi, ƙwarewar haɓaka cholesterol a cikin jini. Hakan ya faru cewa cholesterol dina ya fi na al'ada, ban taɓa gwada shi ba, kuma za su same ni ne kawai a asibiti.

A takaice, likita ya ba da shawarar rage shi, tunda babban cholesterol, ya juya, yana da matukar hadari. Ragewa, rage cin abinci. Bayan binciken ya wuce, ya juya ya zama ƙasa da yadda yake. Don haɓaka sakamako, likita ya umurce ni da miyagun ƙwayoyi "Aorvastatin". Ok, na karba, lokacin cin abincin dare. Bayan kwanaki da yawa na maraba, sai na ji kamar macijin mai dauke da wutar ya zauna a wurina. Ajiyar zuciya mara iyaka, wani abu mara fahimta a ciki.

Bayan mako guda na azabtarwa, na kasance mai wayo sosai don karanta sake dubawa ba kawai akan Otzovik dinmu ba, bayan wannan na fahimci cewa hakan yana faruwa da ni. Da sauri an soke komai kuma rayuwa ta fara inganta. Ban taɓa samun matsalolin ciki ba, don haka ba zan iya tunanin yadda ake tsara waɗannan magunguna ga waɗanda suke da waɗannan matsalolin ba.

Tabbas, dukkanmu mun bambanta, "cewa mutuwa tana da kyau ga Bahaushe-Jamusanci," amma ina tsammanin idan kuna buƙatar kafa wani abu a cikin jiki ta hanyar dabi'a, don haka don Allah, ci gaba da rage cin abinci, ku ci kayan lambu da 'ya'yan itace, kunna wasanni.

Ba na ba da shawara ga abokai, allunan suna "mara nauyi."

Ba na ba da shawarar koma gare su

Atorvastatin Ina ɗaukar shekaru 1, 5. Cholesterol kusan ba a rage shi ba. Shin 4, 6 ya zama 4, 4. Shin yana da daraja a ɗora hanta idan maganin bai yi aiki ba. Da farko na dauki 20 MG, sannan likita ya kara kashi zuwa 30 MG.

Babban adadin sakamako masu illa. Na yi bacci, nauyi a kaina, bayan sati guda na shiga, masifa ta faru: tsananin zafin ya tsananta har ya zama dole in kira motar asibiti, wacce ban taɓa yi ba. Anyi amai, tashin hankali (kuma ban sha wahala daga wannan ba), kusan rasa hankalin. Sun kai ni zuwa 1st Gradskaya, suka yi CT scan, cardiogram, da gwajin jini. Ba su sami wani laifi ba, sai suka kamu da cutar encephalopathy dabam dabam sannan suka tura su gida. Yanzu a ƙarshe na karanta umarnin kuma na sami alamuncina a CIKIN SAUKI NA KYAU. Me kuma zan iya karɓa?

Karanta dukkan littafin. Likitoci sun yi gargaɗi game da yiwuwar sakamako masu illa.

Ya yi gwajin jiki kuma ya bayyana kwayar cutar cholesterol - 7, 6. Likita ya ba da allurar atorvastatin 1 kowace rana Bayan shan kwamfutar hannu na huɗu, matsanancin ya karu, kodayake matsin lamba koyaushe ne al'ada. Dole in kira motar asibiti Yanzu na yanke shawarar daina shan waɗannan kwayoyin. Zan lura kuma in tafi likita don neman shawara.

Zai yiwu furta contraindications.

Na dauki atorvastatin 5 days. Ciwon kai. Hayaniya a kai. Akwai dunƙulen ƙafafun daren yau. Miyagun ƙwayoyi. amma cholesterol 9, 3. Likita ya umarta. Ban da abinci duk samfuran asalin dabbobi. Hagu kawai dafa naman nono ne. Zan ga sakamakon a cikin wata daya.

Na yi nasarar daukar Atorvastatin kwana ɗaya kawai, kuma an tilasta ni in ƙi shi. Wannan maganin ba nawa bane, saboda ina da osteoarthritis da cuta disen degreerative disc tare da ciwon tsoka na baya. Na jima ina shan azaba. Ina tsoro kawai cewa wannan magani bai kamata ya hade da magunguna ba. Kashegari, kunne na na dama an kange shi gaba daya, Na sha wahala daga ciwon kai. Wannan raunin ya karye har na tafi hutun kwana ɗaya in koma in koma daki, Na yi ta kwana a kullun.

An umurce ni da 40 mg na Atorvastatin don ciwon zuciya. Na ci gaba

An umurce ni da 40 mg na Atorvastatin don ciwon zuciya. Na kasance a kai tsawon watanni 9. Yana saukar da kwalagina sosai, amma yana da yawan cutarwa mara kyau! Nan da nan na lura da matsalar ƙwaƙwalwar ƙwaƙwalwa, na fara manta komai, wani irin hazo ne a kaina. Ciwan tsoka kuma ya fara damuwa. Kuma matata ta fara kula da gaskiyar cewa yanayin da nake ciki yana ɓarna, na zama mai fushi da shuɗi, gaba ɗaya ba gaira ba dalili.

Abun ciki da sashi tsari

Atorvastatin (a cikin Latin - Atorvastatinum) ana samuwa ne kawai a cikin kwamfutar hannu. Don hana cutarwa mai illa ga mahallin (danshi, haske, zazzabi) akan abubuwan da ke cikin miyagun ƙwayoyi, da kuma don shan ƙwayoyi da aka yi niyya a ƙananan ɓangarorin ciki da kuma farkon sashin hanji, an rufe su da membrane fim. Launin fim ɗin ya dogara da masana'anta. Yawancin lokaci fari ne, amma wani lokacin launin rawaya, mai haske ko ƙwalƙwallan launin ruwan kasa. Siffar da sifar Allunan suma sunsha banban: suna zama zagaye ko mai kaifin sifa, tare da laushi mai kyau ko tare da zanen lambobi a bangarori daban-daban.

Amma babban abinda ke cikin maganin ba shine gani ba, amma abu mai aiki. Wannan sinadarin alli na atorvastatin ne. Amma tun da abun ciki na atorvastatin da kanta ke taka rawa babba wajen cimma tasirin magani mai mahimmanci, sashi na magunguna yana karkatar da shi ne musamman. Don haka a cikin cibiyar sadarwar kantin magani zaka iya samun Atorvastatin tare da abun ciki na 10, 20, 30, 40, 60 da 80 mg na fili mai aiki. Smallerarancinta kaɗan (1 ko 5 MG), koda a cikin haɗin gabobin hawan jini, ba su wanzu.

A cikin palour sel ɗaya, ana sanya allunan 10 ko 15. Paarin palet ɗin guda ɗaya na iya kasancewa a cikin kunshin, ko watakila ƙari - har zuwa 10. Sau da yawa ana samun wadatattun allunan a cikin gwangwani na polymer. Akwai wasu magunguna na wannan rukunin gona, babban abin da shine atorvastatin. Amma sun riga sun sami wasu, ba na duniya ba (INN), amma sunayen cinikayya (Atoris, Liprimar, Novostat, Tulip, da dai sauransu).

Magunguna na asali Atorvastatin ƙirar Rasha tana cikin wadatar lambar mai:

lambar don ilimin halittar jiki da warkewa (ATX) shine C10AA,
lambar kamar yadda aka danganta da Rashanci OKPD2–20.10.149,
bisa ga rajistar magunguna na Rasha (RLS), samfurin ya kasance ga rukunin kungiyar magungunan "statins".

Atorvastatin ba shine kawai maganin ba. Ya ƙunshi abubuwan jin daɗi: carbonate baƙin ƙarfe, cellulose, sukari madara, sitaci, silicon dioxide, magnesium stearate, polyvinyl giya, titanium dioxide, polyethylene glycol da talc. Masu fama da matsalar rashin lafiyan ya kamata su sani game da su, tunda za a iya inganta kwayar halittar jikin wadannan mahadi.

Ana yin Atorvastatin akan takardar sayan magani, wanda likita ya tsara a cikin Latin. Kuma ko da likitocin marasa lafiya suna shirye su sayar da maganin kyauta, bai kamata ku sha shi ba tare da tuntuɓar likita ba. Tabbas, kafin magani kuma a cikin tsari shi wajibi ne don sarrafa aikin hanta.

Alamu don amfani

Yanayin da aka tsara rubutattun abubuwa ana kiransa dyslipidemia. An fassara shi zuwa harshe mai sauƙi, wannan mai metabolism. Bai bayyana kanta ba na dogon lokaci, kuma kawai tare da ɗimbin ajiya mai "mara kyau" cholesterol a cikin ganuwar jijiyoyin jiki suna fara alamun atherosclerotic na hali. A cikin farkon farawa, ana gano daidaitaccen ƙwayar lipid musamman a cikin dakin gwaje-gwaje. Binciken ana kiransa bayanin martaba, wanda ya hada da manyan alamomin masu kiba - triglycerides, cholesterol, duka kuma bangare ne na hadaddun kitse, sunadarai masu jigilar mai, da na atherogenic.

Ba tare da tantance bayanin martaba na lipid (sunan na biyu na bayanan lipid ba), ba shi yiwuwa a tsayar da sashi da nau'in Statin, wanda mai haƙuri zai daɗe yana ɗauka (kuma, mai yiwuwa, duk rayuwarsa). Bugu da ƙari, bayanin martaba na lipid ya zama dole don sarrafa magani wanda ya riga ya fara. Ana bayar da jini mai laushi don bincike bayan wani shiri mai sauƙi: in ba tare da shi ba, za a iya gurbata sakamakon.

Amfanin atorvastatin shine ingancinta a lura da dukkan nau'ikan hypercholesterolemia (gado da siyayya). Yana rage matakin "mummunan" cholesterol da kuma jigilar furotin wanda za'a iya sanyawa a bangon tsokoki. A lokaci guda, yana haɓakar maida hankali na "mai kyau" na lipoproteins kuma yana ƙaruwa da yawan masu karɓa waɗanda suke kama ƙwayar cholesterol don amfani da ƙwayoyin ciki ko amfani. Bugu da ƙari, atorvastatin yana rage triglycerides a cikin jini, amma wannan baya nufin ana iya ɗauka don asarar nauyi.

Hanyar aiwatar da aiki mai aiki ya samo asali ne daga murkushe babban enzyme wanda ke ɗaukar samuwar cholesterol ta sel hanta. Enzyme ana kiransa hydroxymethylglutaryl coenzyme A reductase, kuma Atorvastatin, bi da bi, mai hanawa ne na HMG CoA reductase. Wannan ingancin maganin yana bada damar kawai dakatar da haɓakar ƙwaƙwalwar atherosclerotic data kasance, har ma don hana bayyanar su cikin mutane tare da haɗarin haɓakar cutar atherosclerosis. Sabili da haka, ana iya tsara shi don tsinkayewar ƙwayar cuta zuwa hypercholesterolemia tun yana ƙarami ko ga masu shan sigari da marassa lafiya bayan shekaru 55.

Statin baya maganin jijiyoyin jini, amma tare da cututtukan zuciya da jijiyoyin jini ko kuma atherosclerosis ya hana rikitarwa kamar bugun zuciya ko bugun jini. Abubuwan da ke nuna alamun yin amfani da su sune siffofin m cututtukan zuciya na jijiyoyin jiki, yanayi bayan su, mummunan haɗarin cerebrovascular. Atorvastatin kuma an wajabta shi a cikin aikin bayan fage a cikin ilimin jijiyoyin bugun jini da na zuciya. Kuma ana samun sakamako mafi kyawu tare da yin amfani da ƙwayar cuta tare da wasu magunguna masu rage yawan lipid kuma a haɗe tare da wasu hanyoyin gyara metabolism mai (abinci, motsa jiki matsakaici, bada mummunan halaye).

Sake dubawa ba

Ni kuma ban taimaka ba kuma akwai wata illa. Nemi daga abincin da aka tsayar .. Kin soki daga tsiran alade, qwai, cuku da man shanu. Kazalika da yin burodi. Bayan watanni 2 ban yi asara ba, amma cholesterol ya girma al'ada

Ya kasance 7.1, bayan ɗaukar shi ya zama 7.2

Magungunan suna da kyau, ko da yake a cikin makonni biyu na farko akwai ƙarancin tashin hankali, to ya wuce. Gamsu da miyagun ƙwayoyi, ƙwayar cholesterol ta koma cikin al'ada 10.3-5.1. Kwanan nan, wani abokin tarayya mai haɗari (atherosclerosis) ya ce an wajabta masa rosuvastatin-sz, shima ya kasance sittin, amma yana kama da mafi zamani wanda yake da ƙarancin sakamako. Ban sani ba idan ya zama dole a canza maganin, tunda tashin zuciya ba damuwa.

Atorvastatin magani ne mai inganci wanda aka dade ana amfani dashi. Abinda kawai ake rubutawa yanzu shine sabon ƙarni na gumaka. Kamar dai an yi imanin cewa sakamako yana da ƙasa da ƙasa. Atorvastatin yana kama da farashi zuwa rosuvastatin-sz, amma ƙarshen ya fi zamani.

A gaskiya ban lura da bambanci tsakanin atorvastatin da rosuvastatin ba. Na dauki atorvastatin na tsawon watanni 4, cholesterol ya koma al'ada, daga baya likitan ya ba da shawarar rosuvastatin-sz - cholesterol kuma yana riƙe, na ji daɗi. Ina fatan cewa sabon magani har yanzu yana da kyau.

Na dauki atorvastatin 2 darussan, yana rage cholesterol sosai, na damu kadan da damuwa, in ba haka ba komai na da ban mamaki. Bayan haka, akan shawarar likita, ya canza zuwa rosuvastatin-sz, wannan shine ƙarni na gaba na statins. Babu sakamako masu illa, suma suna da kyau.

Abvantbuwan amfãni: Ana iya amfani da miyagun ƙwayoyi na dogon lokaci, a cikin ƙarancin magani.

Misalai: Dole ne a yi amfani da miyagun ƙwayoyi tare da analgesic, tunda bayan ɗauka shi ciwon kai ya bayyana.

Na dade ina amfani da miyagun ƙwayoyi, cikin ƙarancin magani, tunda abubuwan da ke cikin cholesterol suna raguwa a hankali. Dole ne ku ɗauka tare da analgesic, saboda bayan ɗaukar shi, ciwon kai ya bayyana. Likita ya ba da umarnin ɗaukar miyagun ƙwayoyi da dare. Sabili da haka, zuwa gado, Ina ɗaukar shi tare da analgesic.

Atorvastatin - magani ne don rage cholesterol

A cikin bazara, yayin da nake tafiya na rashin lafiya tare da matsanancin ƙwayar cutar ta huhu, Na zo ƙarƙashin binciken likita na duniya, dangane da wanda, kamar duk marasa lafiya na shekara ta haihu, Dole ne in sami cikakken jarrabawa (FLG, gwaje-gwaje, duban dan tayi, mammography, da sauransu). Mai ilimin hanyoyin kwantar da hankali ya ba da ƙarshe game da duk sakamakon. A cikin gwajin jini na kwayoyin halittun da aka gano a cikin kwayar cholesterol, triglycerides da wani abu daban a wurin. Mahaifiyata tana da infarction myocardial, Ina da hauhawar jini, don haka likita, yana cewa ni cikin ƙungiyar masu haɗari don haɓakar IHD da bugun zuciya, ya ba ni allunan Atorvastatin Allunan 20 MG 1/2 tab. sau daya a rana. Additionari ga haka, likita ya ce mini in bi cin abinci. Bayan wata daya daga fara magani, na sake wucewa gwajin jini. Likitan bai gamsu da sakamakon ba kuma ya kara kashi zuwa 1 kwamfutar hannu. An yi mini jinya na wata daya. A ƙarshe, magani ya ba da sakamako, ƙwayar cholesterol ta ragu sosai. Na ci gaba da shan Atorvastatin gaba.

Na karanta umarnin - ya Allah, sau nawa sakamako masu illa da wannan maganin zasu iya samu! Kuma likita ya ce zan dau yanzu haka na dogon lokaci, saboda haka ba zan iya guje wa sakamakon ba. Amma har zuwa yanzu ban ga alama ba.

Kyakkyawan magani. Amma an shawarci likitocin zuciya su kimanta kan amfanin-lahani. Tasirin sakamako akan hanta. Kar ka manta cewa statins suna cire duka mara kyau da cholesterol a jiki.

Ba a cutarwa ga magungunan hanta. Kafin ka fara shan gumakan (kwayoyi masu rage jini cholesterol) kana buƙatar canza salon rayuwarka, gaba daya ka sake tunanin abincinka, kuma kawai idan, bayan rabin shekara, cholesterol bai koma al'ada ba, to ka riga ka fara shan Atorvastatin.

Mijinta ya riga ya yi rajista da hypercholesterolemia da hyperlipidemia a cikin gwajin jini na biochemical shekaru da yawa. Abincin ba ya ba da tasiri na musamman, har ma lokacin azumi, lokacin da muka ƙi nama, cholesterol bai ragu zuwa ƙimar al'ada ba. Likita ya umurce shi da magungunan Atorvastatin 10 mg sau daya a rana. Bayan farkon farawar, makonni biyu bayan haka an sami ci gaba a cikin binciken, wata daya daga baya cholesterol ya shiga iyakar babba na al'ada.

Hanyar aiwatar da maganin yana da matukar rikitarwa, da farko ya katse tsarin haɗin cholesterol, abu na biyu yana ƙara yawan masu karɓuwa akan kwayar zuwa cholesterol, wanda ke haifar da saurin amfani da kwayar.

Magungunan ba su da arha don karatun wata - kusan 350 rubles. Kuna iya shan kwamfutar hannu ba tare da la'akari da abincin ba, don haka yana da matukar dacewa, tunda kun manta shan shan kwayoyi da yawa akan komai a ciki sannan ku jira rabin rana lokacin da zaku iya sha. Bayan fara magani, miji yana da tasirin sakamako. Tarihin ilimin halittar jikinsa ya canza, enzymes na hepatic ya yi tsalle kadan, yana da rauni, ciwon kai. Daga baya komai ya tafi, kodayake alamun hanta bai ragu ba har sai an daina amfani da maganin gaba daya. Ya sha Atorvastatin har tsawon watanni biyu.

Gabaɗaya, miyagun ƙwayoyi suna da kyau sosai, yana taimakawa ba mara kyau ba, kodayake ba zai iya yin ba tare da sakamako masu illa ba.

Cikakken ra'ayi

Ina karanta sake dubawa kuma kawai na rikice, na ji wani irin mamaki .. Na kasance ina shan wannan magani tsawon watanni 1.5 kuma ban da wata matsala ta kiwon lafiya .. Kamar yadda ake fama da karancin jini da bugun zuciya, babu babu. Rage, da sauransu, kamar yadda suke cewa A'a. dole ne a yi gwajin jini da kuma cholystyrin don gano, ya kasance 6.2 .. Kuma don haka babu matsalolin kiwon lafiya

Dukkanin magunguna biyu suna jure wa aikin daidai - ragewan cholesterol. Ni kaina na ɗauki atorvastatin-sz, yanzu na ɗauki rosuvastatin-sz. Gaba ɗaya, Na riga na sami "kwarewa" 10 a cikin ɗaukar statins, a cikin 2009 sun sanya rikicewar hypercholesterolemia + rikice-rikice game da ciwon sukari. Atorvastatin-sz ya ɗauki shekaru 7, daga watan biyu na shan 5.8-6.2 sakamako masu illa ba a lura da su ba. Bayan haka, a cikin 2016, sun ba ni shawarar rosuvastatin-sz, magani na Statin-mai zuwa na gaba. Na haye, ban ji wani sauye sauye ba, cholesterol dina ya kasance al'ada. Don haka ina tsammanin - dandano da launi .. Wataƙila mafi zamani, watakila ba a jin wasu matakai.

Ina bayar da shawarar sosai da miyagun ƙwayoyi. Mahaifina ya ɗauki shekara 7, ya tuna game da cholesterol sau ɗaya kawai a kowane watanni shida, lokacin da ya yi bayanin martaba. Yanzu yana shan rosuvastatin-sz, kamar sabon magani, don haka ina matukar farin ciki da wannan. Ee, har yanzu yana da sauƙin ɗauka saboda 1 kwamfutar hannu a rana

Kyakkyawan magani. Ita da kanta ta daɗe kuma mijinta ma ya tashi da kyau. Cholesterol ya kasance al'ada al'ada tsawon shekaru, abun takaici ne kawai kawai kana buƙatar ɗaukar statins duk rayuwarka. wata daya da suka wuce, likitan ya ba da shawarar cewa mijinta ya canza zuwa matukin jirgi na rosuvastatin-sz na zamani. Kwayar cutar, cholesterol ta kasance al'ada. Yanzu ina tunani, shin zan iya canza miyagun ƙwayoyi ko in tsaya a atorvastatin?

Shin ana amfani da dimbin jikin 1 da na 2 har yanzu? Na kawai gani ƙarni 3 a cikin kantin magani na atorvastatin - lokacin da na sha shi, magani ne mai kyau. Da kansa ya rigaya shekara guda ya sami nasarar karba rosuvastatin-sz 4 zamaninsu. Cholesterol 4.5, babu wani sakamako mai illa.

Da miyagun ƙwayoyi ba shakka yana da kyau, ya ɗauke shi kamar shekaru 5. Cholesterol bai wuce yadda aka saba ba. Shekaru 2 da suka gabata, sun maye gurbin (duk abin da likita ya umarta) tare da rosuvastatin-sz, da alama sababbi ne, sakamakon iri ɗaya ne - Ban lura da bambanci ba, amma yana aiki.

Mahaifina ya bugu da Atorvastatin, an sa shi ya sha daga rayuwa. Cholesterol ya ragu sosai, matsalar tana tare da triglycerides. Hakanan an wajabta Dibicor, kuma triglycerides shima ya fara raguwa kuma hanta ta daina buga kayan kwalliya, dibicor ya bayyana yana kare shi.

ya dauki atorvastatin don maganin cholesterol mai yawa, yana taimakawa, amma abin takaici shine ya sanya shi rashin lafiya. Ya nemi likita ya zaɓi wani abu dabam, ya ba da shawarar gwada rosuvastatin-sz - wannan kamar sabon zamani ne. Na dauki wata daya, komai na tsari.

Ina shan atorvastatin-sz a shekara ta biyu, cholesterol kusan al'ada ne, kuma ina ganin ya taimaka min in rasa ɗan kilogram. Ya taimaka mini da yawa, akan abinci guda ɗaya ba zan daɗe ba.

Atorvastatin ss an wajabta mini in rage cholesterol. Muna da matsalar iyali kuma na san hakan. Ina sha shi a kai a kai a cikin darussan, cholesterol ba ya tashi, Ban ga wani lahani ga lafiyar na ba.

Kowane mutum ya rubuta cewa abincin yana taimakawa cholesterol, amma wannan ba haka ba - an daɗe da tabbatar da cewa an samar da babban cholesterol a cikin jikin kanta. Atorvastatin kwaya ce mai kyau kuma tana taimaka wa jiyya, amma wannan shine ƙarni na baya na ɗimbin wuta, yanzu an sami sababbin sabbin abubuwa da yawa. Na ɗauki rosuvastatin-sz - sakamakon yana da kyau, amma tasirin gefen yana ƙasa da ƙasa.

Ban ma san cewa ina da matsala da cholesterol ba, kwatsam, likita ya gano wannan. Na sha hanyar Atorvastatin sz kuma na bi abinci. Cholesterol ya ragu, saboda haka, na ba da shawara.

Lokacin da aka samo ƙwayar cholesterol a cikin bincike, an umurce ni Atorvastatin cz. Na sha wahala sosai daga cin abinci. Amma ya juya a ƙarshe ya rasa nauyi. Kyakkyawan magani, mai farin ciki da shi.

Atorvastatin sz mahaifiyata ta bugu. Tana da matsaloli game da cholesterol da hauhawar hauhawar jini na 2. Cholesterol da gaske ya dawo daidai, muna shan darussan. Akwai sakamako masu yawa da yawa a cikin umarnin, amma mahaifiyata ba ta ga komai ba tukuna.

Yana taimakawa Cholesterol na Jiki

Ina jin kyan gani, bugun jini a cikin jini ya fara zira kwallo. kuma na je wurin likita, na wuce dukkan gwaje-gwaje, na yi wani duban dan tayi na tasoshin kwakwalwa kuma likita ya ba ni allunan otorvostatin. Na fara shan kwamfutar hannu guda biyu na milligram sau 20 a rana a lokaci guda, yanayin na ya fara inganta, hawan jinina ya yi tsalle, da sauransu Duk wata-wata ina yin gwaje-gwaje don tantance cholesterol na jini kuma yayin da nake shan wadannan allunan komai na al'ada ne, Kwanan nan na maye gurbin waɗannan kwayoyin magunguna tare da mafi yawan masu kasuwanci, amma ya zama gaskiya na sami rauni, don haka na koma atorvostatin kuma na ji lafiya

Kwayoyi masu kyau da ke rage ƙwayar jini

Atorvastatin ya taimaka da yawa, cholesterol daga 6, 4 ya ragu zuwa 3, 8, Ina shan ruwa fiye da shekara guda, a hankali yana rage sashi daga 40 mg zuwa 10. Duk wata, Ina ba da gudummawar jini don bincike. Yanzu yana yiwuwa a dauki kashi na tabbatarwa, ba yau da kullun ba, kamar baya, amma misali sau 2 a mako. Don haka yadda za a sha bayan bugun jini Ina da wannan magani don rayuwa!

Uwata ta sha shi, an fitar da ita rayuwa. Tana da kwala 9, kuma hakan yana da yawa. Lokacin da na fara amfani da Atorvastatin, sannan wata daya daga baya ya juya: cewa cholesterol ya koma al'ada. Amma shi, da zarar irin wannan abu, ya bugu koyaushe, tunda jiki ba ya tsara matakinsa saboda rashin aiki na rayuwa. Ba a lura da wata illa ba.

Atorvastatin ya dawo da chocrolina don al'ada. Kodayake a baya an tashe shi kuma abinci mai gishiri-mai-mai da kitse bai taimaka ba, amma wannan magani ya taimaka. Ina bin tsokoki, kamar yadda statins na iya lalata su kuma yana haifar da rauni. Ina ba ku shawara ku yi wannan ga duk cores ɗin da suke shan kwayoyi na wannan rukunin.

Rashin jituwa da magunguna da yawa.

An sanya wannan magani ga kakata, kamar yadda ita, ban da hauhawar jini, tana da cholesterol. Amma, sa'a, wannan magani yana da kyau tare da yawancin magungunan antihypertensive.

A matakin farko, dole ne a sha maganin a rana sau daya, amma yana da matukar muhimmanci a sanya ido a kan matakin cholesterol a cikin jini, wato a dauki gwaje-gwaje. Bayan gwaje-gwaje sun nuna cewa miyagun ƙwayoyi suna aiki ba tare da alamun bayyanar cututtuka ba, ana iya ƙara yawan sashi. Wajibi ne a sanya idanu sosai a cikin lokacin jiyya kada a yi amfani da wasu ƙwayoyi waɗanda zasu iya ƙara yawan aiki a cikin jini, wanda zai haifar da mummunan sakamako. Irin waɗannan magungunan sun haɗa da maganin rigakafi, magungunan antifungal, acid nicotinic.

A ƙarshen wata na farko na ɗaukar ƙwayar cholesterol dina, kakata ta yi ƙasa kuma ta zama cikin iyakoki na al'ada.

Abin takaici, matsalar cutar cholesterol a yau ta shafi mutane da yawa. Idan tun yana karami, jikin ya samu nasarar magance kwayar cutar kwayoyi, to bayan shekaru 35 ya zama dole a sanya ido sosai kan lafiyar kuma dukkan kirdadon jini. Zai fi kyau nan da nan gano cholesterol kuma kada ku ƙyale haɓakawa sama da halayen da aka yarda da su. Idan zaku iya yin gwaje-gwaje kowace shekara, kuma mafi sau da yawa, to, zaku iya saurin sauƙaƙe matakan ƙarfin cholesterol a cikin jini.

Amma idan hakan ya faru da cewa cholesterol har yanzu ya wuce al'ada, to ya kamata kar a dakatar da jiyya a cikin akwati mai tsawo, ya kamata ka ɗauki magungunan da suka dace. Atorvastatin sanannen magani ne don rage cholesterol.

Magungunan ba su da tsada, farashin kusan 160-180 rubles, ana sayar da shi a cikin kowane kantin magani, farashin zai fi dacewa ya dogara da gefen jerin sarkar kantin magani.

Atorvastatin zai yi tasiri kawai a hade tare da abincin da ya dace, an rubuta shi cikin umarnin, likita ya sake maimaita wannan lokacin da ya tsara allunan Atorvastatin.

Yana da matukar muhimmanci a dauki gwaje-gwaje kafin a fara magani domin a tabbatar da yawan tasirin cholesterol, wannan ya zama dole domin yin lissafin daidai magungunan. A cikin maganata, ya kasance kwamfutar hannu 1 sau 3 a rana don wata daya. Dos zai iya zama daban, har zuwa allunan guda 8, amma duk wannan an tsara shi kuma kwararre ne yake duba shi.

Wata daya daga baya, an shirya gwajin jini don gano idan maganin ya warke ko a'a. Bayan wannan lokacin, Na sake ba da gudummawar jini, kamar yadda sakamakon ya nuna, sakamakon ya kasance kuma an sami raguwa sosai a cikin cholesterol, amma har yanzu matakin nata yana waje da ƙa'idar, an yanke shawarar shan Atorvastatin na wani sati 2 tare da sashi guda ɗaya kuma a lokaci guda sha madara mara abinci don hanta. Wannan ƙarin kayan abinci yana taimakawa rage ƙwayar cholesterol.

Bayan wasu makonni 2, gwaje-gwajen sun koma al'ada, nayi ajiyar zuciya, amma wannan ba dalili bane don shakata. Haka ne, an soke Atorvastatin da miyagun ƙwayoyi, amma sai kawai rage cin abinci da kulawa akai na kiwon lafiya.

Magungunan da kaina sun taimaka min, na kawo cholesterol zuwa al'ada, kawai ina buƙatar kiyaye madaidaicin abincin, in ba haka ba za a sami amsa sarkar: cholesterol - Atorvastatin da mataimakin, kuma akwai matsaloli tare da hanta (karanta sakamako masu illa). Magungunan ba su da tsada, aikin ba mafi muni fiye da shigo da shi ba, amma maza, kuna buƙatar ƙaura daga sunadarai kuma ku ɗaura shi da man shanu, tsiran alade da Sweets da sauran farin ciki. Eh ..

Abincin tare da babban cholesterol yana wasa kusan mafi mahimmancin matsayi. Kakata ta kasance tana da wadataccen cholesterol of 10 mmol / L. Likita ya ba da shawarar biye da wani irin abincin: ƙarancin dabbobi mai ƙima (idan nama ne, to, mai ƙanƙan-mai, turkey), karin kayan lambu, 'ya'yan itãcen marmari (zai fi dacewa waɗanda ba su tallatawa ba), kula da tsarin shan ruwa. Atorvastatin an wajabta shi daga magunguna. Kaka ta sha maganin har sau 1 a rana. Watanni shida bayan haka, an sami sakamako masu zuwa: nauyin rage nauyin 14 kilogiram (abinci mai kyau ya taka rawa), cholesterol ya zama al'ada. Yanzu barazanar atherosclerosis ta ƙare.

Pharmacokinetics

Bayan shan atorvastatin, yana dafe cikin hanzari a cikin ƙwayar gastrointestinal, mafi girman yawan hankali a cikin plasma (C_m_ah) ana samunsa bayan awa 1-2. Matsayi na sha yana ƙaruwa gwargwadon adadin da aka ɗauka. Matsakaicin bioavailability na atorvastatin shine 95-99%, cikakken - 12-14%, aikin inhibitory na aikin rage girman HMG-CoA - kusan 30%.

Matsakaicin rarrabuwar atorvastatin shine 381 L, digiri na ɗaukar nauyin sunadaran plasma ya kusan 98%.

Atorvastatin yana metabolized tare da halartar cytochrome CYP3A4 zuwa abubuwan ortho- da para-hydroxylated nade, da kuma samfuran beta-hada abubuwa. Kusan 70% na aikin inhibitory na miyagun ƙwayoyi yana faruwa ne saboda maganin ortho- da para-hydroxylated mai aiki metabolites.

Atorvastatin da metabolites sune abubuwa na P-glycoprotein. Atorvastatin da metabolites suna cirewa musamman tare da bile. Matsakaicin rabin rabin rayuwar atorvastatin shine kimanin awanni 14-15. Sakamakon kasancewar ayyukan magunguna a cikin metabolites, tsawon lokacin ayyukan hanawa ta hanawa HMG-CoA reductase shine 20-30 hours.

Groupsungiyoyin haƙuri na musamman

Tsofaffi marasa lafiya: sarfin plasma na atorvastatin sun kasance mafi girma a cikin tsofaffi (shekaru> shekaru 65) idan aka kwatanta da matasa masu ba da agaji, yayin_, yadda tasirin rage rage kiba ya zama daidai tsakanin shekarun mutanen biyu.

Yara: karatu ba game da kantin magani na yara ba a gudanar da su.

Jinsi: ƙwayoyin plasma na atorvastatin a cikin mata sun bambanta da na maza (kusan 20% mafi girma ga C_m_ah kuma 10% ƙananan ga AUC). Koyaya, babu bambance-bambance masu mahimmanci na asibiti dangane da tasirin lipids a cikin maza da mata.

Marasa lafiya tare da kasawa koda cutar koda ba ta shafi yawan ƙwayar cutar plasma na atorvastatin da tasirin rage kiba ba.

Marasa lafiya tare da raunin hanta: a cikin marasa lafiya da cututtukan hanta na yau da kullun, an lura da karuwa sosai a cikin ƙwayoyin plasma na atorvastatin (C_max) kusan sau 16 da AUC kusan sau 11.

Haihuwa da lactation

Yin amfani da atorvastatin yana contraindicated yayin daukar ciki (duba sashin "Contraindications"). An sami rahotannin rikice-rikice na nakasar cikin jama'a bayan bayyanar cutar ta intrauterine ga masu hana masu rage girman HMG-CoA. Nazarin dabbobi sun nuna sakamako mai guba kan aikin haihuwa. Lokacin da mace mai ciki ta ɗauki atorvastatin, tayin na iya rage matakan mevalonate, wanda shine farkon abubuwan cholesterol biosynthesis. Atherosclerosis wani tsari ne na kullum, kuma, a matsayinka na, kauda magungunan rage rage kiba a lokacin daukar ciki ba ya da wani tasiri a kan hatsarin na dogon lokaci wanda ya shafi babban hypercholesterolemia. A wannan batun, atorvastatin bai kamata a wajabta wa mata masu juna biyu ba, matan da ke shirin daukar ciki ko idan ana zargin juna biyu. Wajibi ne a daina shan atorvastatin yayin daukar ciki.

Ba a san ko ana amfani da sinadarin atorvastatin ba ko kuma ana amfani da shi a cikin madarar mutum. A cikin nazarin dabbobi, yawan ƙwayar plasma na atorvastatin da metabolites dinsa suna kama da waɗanda ke cikin madara. Amfani da atorvastatin yayin shayar da jarirai, mata masu shan atorvastatin yakamata su daina shayarwa (duba sashin "Contraindications").

Sashi da gudanarwa

Kafin fara magani tare da atorvastatin, ya kamata a tura mai haƙuri zuwa abincin da ke tabbatar da raguwa a cikin lipids na jini, wanda dole ne a lura yayin maganin ƙwayoyi.

Yarinyar farawa shine 10 MG kowace rana. Dangane da tasirin da ake so, ana iya ƙaruwa da kullun zuwa ba fiye da 80 MG ba. Ya kamata mai haƙuri ya ɗauki atorvastatin sau ɗaya a kowane lokaci na rana, amma a lokaci guda kowace rana. Ana ɗaukar magani ba tare da la'akari da abincin ba. Ana lura da tasirin warkewa koyaushe bayan makonni biyu na jiyya, kuma mafi girman tasirin yana tasowa bayan makonni huɗu. Sabili da haka, sashi ba za a canza shi ba kafin makonni huɗu bayan fara maganin a cikin kashi na baya.

Abun Ciwon ciki(gadoheterozygousdawanda ba shi da gadohypercholesterolemia) da haɗuwa (cakuda) dyslipidemia (Fredricksonovsky

Yarinyar farawa shine 10 MG kowace rana. Ya danganta da buƙata

sakamakon maganin yau da kullun za'a iya ƙaruwa ba fiye da 80 MG ba.

Homozygous familial hypercholesterolemia

Matsakaicin kashi shine 10-80 MG. A cikin marasa lafiya tare da hyzycholesterolemia na homozygous, ya kamata a yi amfani da atorvastatin azaman maganin haɗin kai zuwa wasu hanyoyin magani ko idan ilimin tare da sauran hanyoyin ba zai yiwu ba.

Heterozygous hereditary hypercholesterolemia a cikin yara (shekaru 10 zuwa 17)

Shawarar fara farawar atorvastatin shine 10 mg / day. Matsakaicin shawarar da aka ba da shawarar ita ce 20 mg / rana (allurai sama da 20 mg ba a gabatar dasu a cikin karatun a cikin wannan yawan haƙuri). Ya kamata a zaɓi kashi ɗin daban-daban dangane da shawarar da aka ba da magani. Ya kamata a aiwatar da canje-canje na ƙwaƙwalwa a cikin tazara na makonni 4 ko fiye.

Yin rigakafin rikice-rikice na zuciya

A cikin bincike kan hana rikice-rikice na zuciya da jijiyoyin jini, an yi amfani da kashi 10 na MG kowace rana. Ana iya buƙatar ƙarin allurai don cimma matakan cholesterol da ake buƙata.

Groupsungiyoyin haƙuri na musamman

Marasa lafiya tare da gazawar koda

Cutar koda ba ta shafi yawan atorvastatin ko ragewa a cikin ƙwayar plasma LDL ba. Sabili da haka, babu buƙatar daidaita sashi na atorvastatin a cikin marasa lafiya da cutar koda.

Marasa lafiya tare da nakasa aikin hanta

Tsanaki ya zama dole dangane da jinkirin kawar da miyagun ƙwayoyi daga jikin mutum (duba sassan "Contraindications" da "Faɗakarwa").

Yin amfani da miyagun ƙwayoyi a cikin marasa lafiya tsofaffi

Lokacin ɗaukar miyagun ƙwayoyi a cikin allurai da aka ba da shawarar, ingancinta da amincin marasa lafiya a cikin waɗanda suka girmi shekaru 70 ba ya bambanta da na yawan jama'a.

Haɗewar amfani da magunguna masu rage yawan rage kiba

Atorvastatin ana iya rubuta shi tare da jerin abubuwan bile acid. Haɗin HMG-CoA reductase inhibitors da fibrates suna buƙatar tsantsan taka tsantsan (duba sassan "Gargaɗi" da "hulɗa tare da wasu kwayoyi").

Sashi a cikin marassa lafiya suna daukar cyclosporine, clarithromycin, itraconazole ko wasu masu hana masu kariya

Marasa lafiya da ke ɗaukar cyclosporine ko masu hana masu kariya na kwayar cutar HIV (tipranavir + ritonavir) ko kwayar cutar hepatitis C (telaprevir) ya kamata su guji magani tare da atorvastatin. A cikin marasa lafiya masu kamuwa da kwayar cutar HIV suna ɗaukar lopinavir a hade tare da ritonavir, ya kamata a yi taka tsantsan lokacin da aka tsara atorvastatin, kuma ya kamata a gudanar da magani tare da mafi ƙarancin tasiri. A cikin marassa lafiya shan clarithromycin, itraconazole, kazalika da masu kamuwa da kwayar cutar HIV suna ɗaukar haɗarin saquinavir da ritonavir, darunavir da ritonavir, fosamprenavir ko fosamprenavir da ritonavir, kashi na atorvastatin yakamata a iyakance zuwa 20 MG, kuma an bada shawarar tabbatar da yin gwajin asibiti da ya dace da tasiri na ƙananan allurai na atorvastatin.

A cikin marasa lafiya da ke ɗaukar inhibitor na hana garkuwar kwayar cutar HIV ko na hepatitis C protease inhibitor boceprevir, kashi na atorvastatin ya kamata a iyakance zuwa 40 MG, kuma ana ba da shawarar gwajin asibiti da ya dace don tabbatar da ingancin ƙananan allurai na atorvastatin (duba "Faɗakarwa") "Hulɗa tare da wasu kwayoyi").

Kariya da aminci

Rashin aikin hanta

An ba da shawarar a kula da aikin hanta (ayyukan enzymes na hanta) kafin a fara jiyya tare da atorvastatin, kuma akai-akai gwargwadon alamun asibiti. Akwai rahotannin tallace-tallace da ba a taɓa samu ba bayan gazawar cuta da rashin gajiya mai rauni a cikin marasa lafiya da ke ɗauke da siffofin ciki har da atorvastatin. Idan kan aiwatar da shan atorvastatin mummunan lalacewar hanta ta haɓaka tare da alamun asibiti da / ko hyperbilirubinemia ko jaundice, to ya kamata a dakatar da magani nan da nan. Idan har ba a kafa sauran dalilai na aikin hanta mai rauni ba, to ba a ci gaba da gudanar da tsarin kulawar atorvastatin ba.

Ya kamata a tsara Atorvastatin tare da taka tsantsan ga marasa lafiya waɗanda ke shan giya da / ko kuma suna da tarihin cutar hanta. Cutar cututtukan hanta a cikin aiki mai aiki, ko karuwa a cikin ayyukan transaminases tare da sanadin da ba a sani ba, sune contraindication don gudanar da atorvastatin.

Yin rigakafin cutar sankara ta hanyar Rage Cholesterol mai karfi

A yayin karatun, an gano cewa a tsakanin marassa lafiya da basa fama da cutar sankarar zuciya wanda kwanannan ya kamu da bugun jini ko kuma tashin hankali ischemic, ana yawan lura da bugun jini a cikin marasa lafiya da suke karbar 80 MG na atorvastatin fiye da marasa lafiya da ke karbar placebo. Musamman, an lura da karuwar haɗari a cikin marasa lafiya waɗanda suka riga sun kamu da cutar bugun jini ko ƙarancin maciji a lokacin da binciken ya fara. Ga marasa lafiya da cutar bugun jini na baya ko_, rashin daidaituwa, daidaituwa na hadarin / fa'idar rabo na kashi na atorvastatin 80 MG ba a bayyane ba, yakamata a duba yiwuwar haɗarin bugun jini na farawa kafin fara maganin.

Tasiri a jikin kasusuwa

Yayin kulawa da atorvastatin, kamar yadda ake amfani da kwayoyi masu kama da wannan rukunin, ba a taɓa ganin lamuran rhabdomyolysis ba, waɗanda ke tattare da mummunan lalacewa na renal sakamakon myoglobinuria. Tarihin lalacewar renal na iya zama haɗarin haɗari ga haɓakar rhabdomyolysis. A cikin irin waɗannan marasa lafiya, ƙarin saka idanu sosai game da aikin ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta ya zama dole.

Jiyya tare da atorvastatin, kamar sauran statins, na iya haifar da myopathy, wanda aka bayyana ta hanyar jin zafi da rauni na tsoka, haɗe tare da karuwa a cikin aikin creatine phosphokinase (CPK) fiye da sau 10 idan aka kwatanta da babba na al'ada. Amfani mai haɗari na babban allurai na atorvastatin da wasu kwayoyi, kamar cyclosporine da mai hana CYP3A4 inhibitors (misali, clarithromycin, itraconazole da inhibitors na HIV), yana ƙaruwa da haɗarin kamuwa da cuta / rhabdomyolysis.

Akwai rahotannin da ba a sani ba game da ci gaban cututtukan cututtukan ƙwayar tsohuwar ƙwaƙwalwar ƙwayar cuta, autoimmune myopathy da ke hade da ɗaukar statins. Ana nuna halin rashin daidaituwa na ƙwaƙwalwar ƙwayar cuta mai lalacewa da ƙarancin ƙwayar tsoka da haɓakawa a cikin matakan ƙirar chikin mahaifa, wanda ke ci gaba koda bayan magani tare da statins an daina aiki, biopsy na tsoka yana bayyana necrotic myopathy ba tare da gagarumar kumburi ba, haɓaka yana faruwa lokacin da aka ɗauki magungunan immunosuppressive.

Myopathy ya kamata a tuhume shi a cikin kowane haƙuri tare da yaduwar myalgia, tashin hankali na tsoka ko rauni, da / ko alamar karuwa a cikin aikin CPK. Ya kamata a faɗakar da marasa lafiya cewa ya kamata su sanar da likita nan da nan game da bayyanar raunin da ba a bayyana ba ko rauni a cikin tsokoki, idan suna tare da zazzabi ko zazzabi. Ya kamata a dakatar da maganin atorvastatin idan an sami ƙaruwa sosai a cikin ayyukan CPK ko kuma a gaban tabbatar ko wanda ake zargi da cutar myopathy.

Hadarin myopathy lokacin da aka magance shi da sauran kwayoyi na wannan aji ya karu tare da amfani da cyclosporine, fibrates, erythromycin, clarithromycin, hepatitis C protease inhibitor telaprevir, haɗuwa da masu kare lafiyar HIV, ciki har da saquinavir da ritonavir, lopinavir, ritonavir ritra da ritonavir, nicotinic acid, ko magungunan antizog azole. Lokacin da ake rubuta atorvastatin a hade tare da fibrates, erythromycin, clarithromycin, haɗuwa da saquinavir da ritonavir, lopinavir da ritonavir, darunavir da ritonavir, fosamprenavir, fosamprenavir da ritonavir, tare da azole antifungal miyagun ƙwayoyi a saka idanu kan marasa lafiya akai-akai don gano kowane alamun ko alamun raunin ƙwayar tsoka ko rauni, musamman ma a cikin farkon watanni na jiyya da lokacin haɓaka eskers wani magani. Ya kamata a ba da allurai na atorvastatin da keɓaɓɓen lokacin da za'ayi amfani da su a lokaci ɗaya tare da waɗannan magungunan. A cikin irin waɗannan yanayi, ana iya bada shawarar ƙaddara na ayyukan KFK na lokaci-lokaci, kodayake irin wannan kulawa ba ta hana ci gaban mummunan tashin zuciya ba.

Shawarwari don saduwa da magungunan hulɗa an ba su a cikin tebur 1.

Tebur 1. Haɗaɗɗɗan Magunguna tare da Rara Hadarin Ci gaba
myopathies / rhabdomyolysis________________________________________________________

Abun Harkokin Magungunayana nufin

Shawarwarin da aka tsara,.

Cyclosporin, masu hana HIV kariya (tipranavir + ritonavir), hepatitis C protease inhibitor (telaprevir)

Ya kamata a guji yin Atorvastatin

Inhibitor na kariya daga kwayar cutar HIV (lopinavir + ritonavir)

Yi amfani tare da taka tsantsan, a mafi ƙasƙanci mai tasiri mai tasiri.

Clarithromycin, itraconazole, masu hana HIV kariya (saquinavir + ritonavir *, darunavir + ritonavir, fosamprenavir, fosamprenavir + ritonavir)

Karka wuce kashi 20 na rana

Inhibitor na kariya daga kwayar cutar kanjamau (nelfinavir), maganin hepatitis C mai hana kansa kariya (boceprevir)

Karka wuce kashi 40 na kullum

* Yi amfani da hankali tare da ƙarancin kashi.

An ba da rahoton maganganun maganganu na cututtukan zuciya, ciki har da rhabdomyolysis tare da haɗin gwiwar atorvastatin tare da colchicine, don haka ya kamata a yi taka tsantsan a wannan yanayin.

Yakamata a gargadi marassa lafiya cewa yakamata su nemi likita kai tsaye idan zafin da ba a bayyana ba ko rauni na tsoka ya faru, musamman idan suna tare da zazzabi ko zazzabi.

Kafin farawan magani

Ya kamata a tsara Atorvastatin tare da taka tsantsan ga marasa lafiya waɗanda ke da tabbas game da rhabdomyolysis. Ya kamata a ƙaddara matakin CPK kafin farawa a cikin halaye masu zuwa:

- cututtukan tsoka na gado a cikin mutum ko tarihin iyali,

- ƙwayoyin tsoka da suka gabata saboda amfani da statins ko fibrates,

- cututtukan hanta na baya da / ko zagi,

- tsofaffi marasa lafiya (fiye da shekaru 70) - buƙatar buƙatar bayanan dakin gwaje-gwaje a wannan yanayin ana haifar da shi ta dalilin wasu abubuwan da ke haifar da rhabdomyolysis,

- kararraki na kara maida hankali (alal misali, maganganu na cudanya da amfani a cikin mutane na musamman, gami da tarin kwayoyin halitta).

A cikin lamuran da ke sama, ya kamata a kimanta alaƙar da ke tsakanin haɗari da fa'ida mai amfani, an bada shawarar lura da asibiti.

Tare da haɓakawa mai mahimmanci a cikin taro na KFK (ƙetaren iyakar ƙimar ƙa'idodi ta fiye da sau 5) a matakin farko, bai kamata a fara ba da magani ba.

Auna matakan CPK

Bai kamata ku auna matakin CPK ba bayan matsanancin ƙoƙari na jiki ko kuma a gaban sauran abubuwan da ke da alhakin ƙara yawan CPK, saboda wannan zai rikita fassarar sakamakon bincike. Idan matakan farko na CPK suna ƙaruwa da yawa (fiye da sau 5 idan aka kwatanta da babba na yau da kullun), ya zama dole a sake nazarin bayan kwanaki 5-7 don tabbatar da sakamakon.

An ba da rahoton karuwa a cikin HbAlc na azumi da kuma maganin glucose mai cin abinci tare da masu hana zirga-zirgar HMG-CoA, tare da atorvastatin. Statins shafi cholesterol kira kuma a ka'idoji na iya hana samar da kwayoyin homon na adrenal cortex da / ko hormones steroid. Nazarin asibiti ya nuna cewa atorvastatin baya ragewa babban cortisol maida hankali ne kuma baya cutar da adrenal gland shine yake. Ba a yi nazarin sakamakon ƙirar jikin mutum ba. Sakamakon, idan akwai, akan tsarin pituitary-gonadal a cikin mata yayin farawar jini ba a sani ba. Dole ne a kula da hankali lokacin da ake tsara mutum-mutumi tare da kwayoyi waɗanda zasu iya runtse matakin ko aiki na kwayoyin steroid na endogenous kamar ketoconazole, spironolactone da cimetidine.

Statins, a matsayin aji, na iya haɓaka glucose na jini, kuma a cikin wasu marasa lafiya da ke da haɗarin kamuwa da ciwon sukari, suna iya haifar da hyperglycemia, wanda ke buƙatar daidaitattun matakan don maganin cututtukan sukari. A lokaci guda, raguwa a cikin hadarin cututtukan zuciya da jijiyoyin jiki ke mamaye hadarin cutar sankarar mama, don haka ba a buƙatar dakatar da maganin jiyya. Marasa lafiya a cikin haɗarin kamuwa da ciwon sukari (glucose mai azumi na 5.6-6.9 mmol / L, ƙididdigar ƙwayar jiki> 30 kg / m 2, haɓakar triglycerides, hauhawar jini) suna buƙatar sa ido na asibiti da kuma nazarin kwayoyin.

Cutar kuturta

Lokacin gudanar da aikin jiyya tare da amfani da wasu mutum-mutumi, musamman yayin tsawan magani, al'amuran cututtukan huhu na da matukar wahala. Bayyanar cutar ta hada da alamomi kamar dyspnea, tari mai bushewa, da kuma rashin lafiyar gaba daya (gajiya, nauyi, da zazzabi). Idan kuma ana zargin cutar cututtukan huhu da katsewa, ya kamata a dakatar da yin amfani da maganin chikin steatin.

Bayanai na Musamman kan Kayan Kayan Magani

Atorvastatin ya ƙunshi lactose. Wannan magani bai dace da marasa lafiya da ke fama da rashin haƙuri na galactose ba, rashi na enzyme lactase, ko glucose da cutar malabsorption na galactose.

Yi amfani da shi a cikin tsofaffi marasa lafiya

Tsofaffi (shekaru 65 da haihuwa) shine sanadiyyar yanke hukunci don cutar kansa, saboda haka ya kamata a tsara maganin cutar ta atorvastatin ga marasa lafiyar tsofaffi tare da taka tsantsan.

Yi amfani da lokacin daukar ciki da lactation

Mata masu haihuwa

Ya kamata matan da suka isa haihuwa suyi amfani da hanyoyi masu inganci na hana haihuwa yayin aikin jiyya.

A cikin nazarin dabbobi, atorvastatin bai shafi haihuwa namiji ko mace ba.

Tasiri kan iya tuka motocin da ke da hatsarin kayan aiki: Babu wani rahoton mummunan tasirin atorvastatin akan taro.

A lokacin daukar ciki da lactation

Ba a gudanar da bincike a cikin wannan shugabanci ba, kuma ba wanda ya san yadda Atorvastatin ke shafar tayin kuma ko ya shiga cikin nono. Don haka, ba a ba su magungunan mata masu juna biyu ba, kuma idan ya zama tilas a daukeshi yayin shayarwa, an tura yaro zuwa ciyar da jabu. Dangane da haka, matan masu haihuwa, yayin da suke shan sakin jiki, ana ba da shawarar yin amfani da hanyoyin isasshen hanyoyin hana haihuwa don kawo yiwuwar samun juna biyu zuwa sifili.

Atorvastatin an wajabta shi ne kawai ga tsofaffi, kuma an yi nufin duka biyu don magance cututtukan ƙwayar cuta na lipid da kuma rigakafin rikicewar cututtukan zuciya da keɓaɓɓiyar asalin cututtukan ƙwayoyin cuta na atherosclerosis. Ba a fahimci tasirin statin a kan yara da matasa ba, don haka likitoci ba sa haɗarin yin amfani da shi a cikin marasa lafiya da ke ƙasa da shekara 18.

Side effects

Yiwuwar tasirin sakamako masu ƙaranci: sakamako mai illa yana faruwa a cikin 1-3% na lokuta na amfani da Atorvastatin na dogon lokaci.

Mafi sau da yawa, waɗannan alamun cututtukan jijiyoyin jiki ne a cikin yanayin rashin bacci, ciwon kai, da ciwo mai wahala.
Sakamakon gaskiyar cewa abu mai aiki yana shafar hanta, dyspepsia na iya haɓaka - bloating, tashin zuciya, zawo ko maƙarƙashiya, jin zafi a ciki.
Wani lokacin akwai ciwon mara na lokaci-lokaci.
Koyarwar ta kira rashin lafiyan (daga ƙyashin fata zuwa anaphylaxis), raguwa don iko, keta alfarma na jijiyoyin gefen ciki, ƙwanƙwasawa, da raɗaɗin haɗin gwiwa kamar tasirin sakamako.
Yana da matukar wahalar haɓaka maganin hepatitis ko pancreatitis, canje-canje a cikin abubuwan da ke faruwa a cikin jini ya faru: raguwa a cikin adadin platelet, karuwa a cikin matakan hanta enzymes.
A cikin lokuta daban, rikodin rhabdomyolysis - lalata ɓoyayyun ƙwayoyin tsoka tare da toshewar twarar sunadarai ta samfuran su na lalata, wanda ke haifar da gazawar haɓaka mai girma.

Ya kamata a ba da kulawa ta musamman ga marasa lafiya ciwon sukari iri biyu. Cutar sankarar cututtukan cututtukan ƙwayar cuta shine bayyananniyar bayyanuwar cutar. Kuma wannan ba komai bane face haɓakar cututtukan jijiyoyin bugun zuciya. Atorvastatin an wajabta shi ga masu ciwon sukari lokacin da aka gano dyslipidemia. Shin yana hawan jini? Amsar tana da ma'ana: komai abu ne na mutum; miyagun ƙwayoyi na iya shafar matakan glucose, amma na iya haifar da hyan hypo- ko hyperglycemia. Amfani da maganin statin don nau'in 1 da nau'in ciwon sukari na 2 ya ƙunshi saka idanu na yau da kullum game da sugars.

Siffofin aikace-aikace

Kafin tsara Atorvastatin, likitoci suna ƙoƙarin cimma nasarar dawo da ma'aunin lipid ta abinci, aikin jiki, asarar nauyi. A zahiri, wannan dabarar ta ci gaba har tsawon lokacin jiyya. Nan da nan kafin kashi na farko na sarrafa magani aikin hanta. Sannan ya zama dindindin: makonni 1.5 bayan fara maganin, bayan watanni 3, sannan kuma - kowane wata shida da bayan kowace canji a matakin.

Bugu da kari, ana duba hanyoyin kula da cututtukan da ke tattare da cututtukan fata kafin a fara amfani da su. Tare da hawan jini, hypothyroidism, kiba, cututtukan hanta, an zaɓi magunguna masu dacewa ko kuma sashi da aka yi amfani da su, bisa ga maganar. Hakanan, an gargadi marasa lafiya game da yiwuwar kamuwa da cutar sankarar mahaifa, sabili da haka dole ne su sanar da likitan su game da kowane ciwo na tsoka.

Karamin hanya Ba a tsara jiyya don wasu 'yan kwanaki ba, kuma zai iya kasancewa muddin kwararrun ya ce. Yawancin lokaci ƙarami shine 'yan watanni. Bayan haka, rashin daidaiton ƙwayar lipid ya inganta tsawon shekaru ko ma shekarun da suka gabata. Hakanan zai dauki tsawon lokaci kafin a gyara shi. Sabili da haka, tambayar ko zaku iya yin hutu don kanku kada ta kasance: allunan dole ne su bugu koyaushe. Ba tare da hutu ba, ana iya ɗaukar Atorvastatin na tsawon shekaru, kuma tsawon lokacin da za'a ɗauka don yin wannan a kowane yanayi - bayanin martaba na lipid zai faɗi.

Tare da aikin hanta mai rauni

Atorvastatin an yarda dashi kawai a cikin rashin ilimin cutar hanta ko tare da ƙarancin digiri na rashin hanta. Koyaya, yana kimanta buƙatar amfanin sa da yuwuwar sauya wasu hanyoyi waɗanda basu da tasiri a hanta. Kulawa da ayyukan aikin hepatocytes dangane da gazawar hanta na da matukar muhimmanci. Tilas ne a yi nazari kan lokaci da kuma bayan shiri da ya dace.

Farashin magani

Ana samar da magunguna na wannan rukunin magunguna a cikin ƙasashe da yawa, kuma farashin Atorvastatin ya dogara da masana'anta. Koyaya, kuma kan sashi a cikin milligrams, da kuma yawan adadin allunan a cikin kunshin. Analogues a kan farashin shirye-shiryen Ukrainian, Rashanci, Indiya da Ingilishi.

Kudin karatun wata-wata tare da kashi 20 a kowace rana na magunguna a cikin magungunanmu daga 90 ± 20 UAH. ko 250 ± 80 rubles. Al'adun Isra’ila sun fi tsada sau 1.5, Mutanen Spain sun fi sau 2 tsada, Amurkawa da Jamusanci sun fi tsada sau 3-4.

Wace madaidaiciyar ƙwayar atintvastatin ce mafi kyau

A kan kantin magani, sau da yawa kusa da sunan asali shine yankewa ko wata kalma, alal misali, Atorvastatin SZ ko Atorvastatin MS. Wadannan barbashi suna nuna masana'antun daban-daban. A cikin waɗannan halayen, muna magana ne game da kamfanonin magunguna na Rasha Severnaya Zvezda da Medisorb. A kan sauran kunshin za ku iya ganin ƙarin kalmomi "Pranapharm", "Ozone", "LEXVM", "Vertex", "Canonfarm", "Akrikhin", "Actavis", "Biocom", "ALSI Pharma".

Daga cikin analog ɗin ana shigo dasu ana samun Atorvastatin Alkaloid (Makedonia), Atorvastatin Teva (Isra'ila), Ananta (India), Pfizer (Amurka), Blufish (Sweden), Ratiopharm (Jamus), “ Aveksima "(kamfanin kasa da kasa) ... Ba zai yiwu a iya dogaro da kai a ce wacce magungunan kamfanin ta fi kyau ba. A zahiri, waɗannan kalmomi ne, analogues kai tsaye. Statins da ake kira Atorvastatin suna dauke da abu guda mai aiki. Sun bambanta kawai a kayan aikin taimako: Allunan za'a iya maye gurbinsu ta amfani da waɗanda basu da tasirin sakamako a cikin tsarin aikin mutum. Koyaya, kamar magungunan tushen atorvastatin tare da wasu sunayen kasuwanci.

Wannan tabbatacce ne ta hanyar nazarin kwararru da marasa lafiya: an zaɓi magunguna masu haƙuri da aka dogara da atorvastatin ga marasa lafiya, kuma maye gurbin bai yi tasiri ba a cikin sakamakon furotin mai amfani. Amma ba wanda ya yi nasarar cikakken nasarar sauya kayan magunguna tare da magungunan jama'a.

Yin Amfani da Bita

Mutane da yawa, kafin fara magani, suna so su san ra'ayin mai zaman kansa na likitocin (likitocin, likitocin zuciya), kazalika da sane da sake duba lafiyar marasa lafiyar da suka sha wannan maganin. Bayan binciken kwararru da marasa lafiya, mutum na iya kusantar da irin wannan yanke hukuncin:

Atorvastatin shine maganin zabi ga likitoci da yawa saboda yawan ingancinsa da halayen da ba a sani ba,
yawancin marasa lafiya da suka dauki kwayoyin hana daukar ciki cholesterol sun lura da haɓakawa da kyautatawa, musamman waɗanda suka maye gurbin sabon ƙarni na statin tare da rosuvastatin tare da atorvastatin saboda yawan sakamako masu illa,
kawai karamin kaso na marasa lafiya lokacin da shan miyagun ƙwayoyi sun koka da tsananin rashin ƙarfi, rauni da ciwon kai, amma waɗannan tsofaffi ne waɗanda aka wajabta masu maganin sosai.